Mónica Santos (4012-F7AE-EC08)

Curriculum Vitae

Mónica Santos

Mónica Santos. Completed her PhD in Biomedical Sciences (2007) by the University of Porto, Institute of Biomedical Sciences Abel Salazar and her B.Sc. in Biology (2000) by the University of Porto, Faculty of Sciences. She is a Researcher in the University of Coimbra, Center for Neurosciences and Cell Biology. She published 25 articles in peer-reviewed journals. Organized scientific and public outreach events and kept a continuous scientific formation by attending top scientific meetings, participating in workshops and conferences and got training in soft skills. She co-supervised 2 PhD theses and 4 MSc theses and supervised several postgraduate students. She has received 8 awards and/or honors. Participates and/or participated as Principal Investigator in 4 projects and as Team member in 12 other projects. She earned 3 highly competitive fellowships, 1 PhD and 2 Pos-doctoral fellowships. Works in the area of Medical and Health Sciences with emphasis on Basic Medicine and Neurosciences. In her professional activities interacted with 309 collaborators, including collaborations from the non-academic sector (notably hospitals) and overseas (USA) with co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: NT3-TrkC; FMR1; MECP2; Anxiety; Fear; Learning and Memory; Neurotrophins; Animal models; Neurodegeneration; Rett syndrome; Down syndrome; FXTAS; Rodent behavior; Endocannabinoids; Mecp2-mutants; Fear conditioning; Fear extinction; FMR1 premutation; Gene therapy; Ts65Dn mouse model; Intellectual disability; TrkC; Neurotrophin 3; Neurodevelopment; Autism; MECP2 mutations; Multiple Sclerosis; Genetic markers; Social behaviour; Olfactory system; Mouse model; Noonan syndrome; Rasopathies; microRNA; Panic disorder; Public Outreach .

Ler resumo completo ↓

Identificação

Identificação pessoal

Nome completo: Mónica Santos

Nomes de citação

Santos, Mónica
Santos, M
Santos, Monica

Identificadores de autor

Ciência ID: 4012-F7AE-EC08
ORCID iD: 0000-0003-3229-8270

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110 (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Espanhol; Castelhano	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Catalão	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)
Francês	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)
Alemão	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2002/02/20 - 2007/12/20 Concluído	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Pathogenesis of Rett Syndrome and Study of the Role of Mecp2 Protein in Neuronal Function" (TESE/DISSERTAÇÃO)
2005/05/02 - 2005/05/13 Concluído	Laboratory Animal Science, Category C (Pós-Graduação) Federation of Laboratory Animal Science Associations (FELASA), Reino Unido
1996/09/20 - 2000/11/16 Concluído	Biologia (Licenciatura) Especialização em Científico Universidade do Porto Faculdade de Ciências, Portugal	15

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/04/08 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/09/01 - 2017/06/30	Investigador Contratado (Investigação)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2008/01/01 - 2013/06/30	Pós-doutorado (Investigação)	Centre de Regulació Genòmica, Espanha
	Centre de Regulació Genòmica, Espanha
2002/02/20 - 2007/12/20	Investigador (Investigação)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal (...)
2002/08 - 2002/09	Investigador visitante (Investigação)	Universidade Estadual de Campinas, Brasil
	Universidade Estadual de Campinas, Brasil
2000/11/01 - 2002/02/19	Investigador (Investigação)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/06 - 2001/10	Investigador visitante (Investigação)	University of Cambridge Addenbroke's Hospital, Reino Unido
	University of Cambridge Addenbroke's Hospital, Reino Unido
1999/03/01 - 2000/09/30	Estagiário de Investigação (Investigação)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2022/09/01 - Atual	Professor Auxiliar Convidado (Docente Universitário)	Escola Superior de Enfermagem de Coimbra, Portugal

2021/09/01 - 2022/01/31	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Outras Carreiras

	Categoria Profissional Instituição de acolhimento	Empregador
2018/09/17 - 2019/04/05	Professor do ensino básico e secundário (Professor do ensino básico e secundário)	Associação Semear Talentos, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2010/09/01 - 2012/07/31	Chair of the student's committee	8th FENS Forum, Espanha
	Spanish Society of Neuroscience, Espanha
2008/09/01 - 2009/07/31	Member of the Young Neuroscientist's committee	XIII Forum of the Sociedad Española de Neurociencias (SENC), Espanha

Projetos

Bolsa

	Designação	Financiadores
2019/10/08 - Atual	BrainHealth 2020 - Early detection, Neuromodulation and Advanced Therapies to Brain Disorders. CENTRO-01-0145-FEDER-000008 Bolseiro de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	PT2020-CENTRO 2020 (FEDER) Em curso
2016/12/30 - Atual	Maternal Defence, Reward and Olfaction: Neurobiology of Social Behaviours Guided by Pheromones in Mice BFU2016-77691-C2-1-P Outra Facultat De Ciencies De La Salut, Universitat Jaume I, Espanha	Ministry of Economy, Industry and Competitiveness Concluído
2025/01/01 - 2028/12/31	Neuroendocrine basis of atypical social and anxiety-like behaviour in Mecp2 deficient mice, model of Rett syndrome CIAICO/2023 Investigador Universitat de València, Espanha	Em curso
2020 - 2023	Structural plasticity in the olfactory system: impact of maternity, early stress and Mecp2 deficiency PID2019-107322GB-C22 Outra Universitat de València, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Em curso
2015/03/01 - 2018/03/30	Preclinical approaches towards therapeutic intervention for fragile X premutation carriers 01GM1505 Outra Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluído
2016 - 2018	Neurobiology of social behaviour. Experimental study of the aggressive and autistic brain in mice models UJI-B2016-45 Outra Facultat De Ciencies De La Salut, Universitat Jaume I, Espanha	Universitat Jaume I Concluído
2015 - 2017	Neurobiology and Neurocognitive function in mousse models of Rasopathies. FKZ 1GM1519A Outra Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluído
2012/07/01 - 2013/06/30	Knockdown of HAS 21-syntenic miRNAs in Ts65Dn mice by adeno-associated viral vectors. Consequences on hippocampus-dependent phenotypes 01_CF Investigador Pós-doutorado Institut d'Investigacions Biomèdiques August Pi i Sunyer, Espanha	Fondation Jérôme Lejeune Concluído
2011/01/01 - 2012/06/30	Molecular bases of the functional role of the alternative splicing Ntrk3 WT and insert isoforms in learning and memory processes that rely on the cortico-hippocampal circuit. 07_M Bolseiro de Pós-Doutoramento Centro de Regulación Genómica, Espanha	Fundación Ramon Areces Concluído
2002 - 2005	Clinical, epidemiological and genetic study of Rett syndrome in Portugal. POCTI 41416/2001 Investigador Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2001 - 2003	Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES). Genomic screen of 6000 markers in the pooled Portuguese sample. 057097 Bolseiro de Técnico de Investigação Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Addenbrooke's Hospital Department of Neurology, Reino Unido	Welkome Trust (UK) Concluído

Projeto

	Designação	Financiadores
2019/03/01 - Atual	Role of NT3/TrkC in the regulation of fear 85/18 Investigador responsável Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação Bial Em curso
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2024/03/01 - 2025/02/28	Drug screening - ProRett 2024/1 Co-Investigador Responsável (Co-IR) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Pro RETT Ricerca Em curso
2021/07/01 - 2023/06/30	An investigation on the MeCP2-early life stress interaction effects in anxiety sensitivity later in life in a mouse model of Rett syndrome 2046/2021 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fondation Jérôme Lejeune Em curso
2021/03/01 - 2021/05/31	Regulation of mitochondria fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis PTDC/MED-NEU/3736/2020 co-Principal Investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/10/07 - 2021/04/06	The endocannabinoid system and Rett syndrome: neuroanatomical, neurochemical and behavioural analyses 2/2019 Investigador responsável Universitat de Valencia Facultat de Ciències Biològiques, Espanha Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	FinRett Em curso
2013/09/01 - 2016/04/30	Experimental approaches towards therapeutic intervention for Fragile X-associated Tremor Ataxia Syndrome 01GM1302 Investigador responsável Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha	Bundesministerium fur Bildung und Forschung Dienststelle Bonn Concluído
2012/07/01 - 2013/06/30	Phenotypic rescue of the Ts65Dn Down syndrome mouse model using a miRNA decoy approach. U716 Bolseiro de Pós-Doutoramento Centre de Regulació Genòmica, Espanha Institut d'Investigacions Biomèdiques August Pi i Sunyer, Espanha	Centro de Investigación Biomédica en Red de Enfermedades Raras Concluído
2008/01/01 - 2010/12/31	Understanding the impact of panic attacks on brain systems involved in the pathophysiology of panic disorder: cognitive, neural and molecular mechanisms. SFRH/BPD/28555/2006 Bolseiro de Pós-Doutoramento Centre de Regulació Genòmica, Espanha	Fundação para a Ciência e a Tecnologia Concluído
2002/12/01 - 2006/11/30	Study of Rett syndrome pathogenesis and the role of MeCP2 protein in the neuronal function. SFRH/BD/9111/2002 Bolseiro de Doutoramento Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Ventura, Rossella; Di Segni, Matteo; Santos, Mónica; Agustín-Pavón, Carmen; Torres-Pérez, Jose V.. "Editorial: Long-lasting neurobehavioral effects of early-life events". Frontiers in Neuroscience 18 (2024): http://dx.doi.org/10.3389/fnins.2024.1509723. 10.3389/fnins.2024.1509723 Beatriz Rodrigues; Ricardo A. Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela S. Inácio; Mónica Abreu; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". Molecular Psychiatry (2024): https://doi.org/10.1038/s41380-024-02715-1. 10.1038/s41380-024-02715-1 Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://dx.doi.org/10.1038/s41380-024-02412-z. No prelo • 10.1038/s41380-024-02412-z Francisca Silva; Gianluca Masella; Maria Francisca Madeira; Carlos B. Duarte; Mónica Santos. "TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory". Molecular Neurobiology (2023): https://doi.org/10.1007/s12035-023-03292-0. 10.1007/s12035-023-03292-0 María Abellán-Álvaro; Oliver Stork; Carmen Agustín-Pavón; Mónica Santos. "MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice". Journal of Neurodevelopmental Disorders (2021): https://doi.org/10.1186/s11689-021-09409-7. 10.1186/s11689-021-09409-7 Elena Martínez-Rodríguez; Ana Martín-Sánchez; Emre Kul; Aparajita Bose; Francisco José Martínez-Martínez; Oliver Stork; Fernando Martínez-García; et al. "Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour". Brain Structure and Function 225 7 (2020): 2219-2238. https://doi.org/10.1007/s00429-020-02122-6. 10.1007/s00429-020-02122-6 Martínez-Rodríguez, Elena; Martín-Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Stork, Oliver; Martínez-García, Fernando; et al. "Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system". Brain Structure and Function 224 4 (2019): 1647-1658. http://dx.doi.org/10.1007/s00429-019-01860-6. Publicado • 10.1007/s00429-019-01860-6 Castro, Hoanna; Kul, Emre; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; Hukema, Renate K.; Stork, Oliver; Santos, Mónica. "Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome". Human Molecular Genetics 26 11 (2017): 2133-2145. http://dx.doi.org/10.1093/hmg/ddx108. Publicado • 10.1093/hmg/ddx108 Altmüller F; Pothula S; Annamneedi A; Nakhaei-Rad S; Montenegro-Venegas C; Pina-Fernández E; Marini C; et al. "Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.". PLoS genetics (2017): http://europepmc.org/abstract/med/28346493. Acesso aberto • 10.1371/journal.pgen.1006684 Altmüller, F.; Pothula, S.; Annamneedi, A.; Nakhaei-Rad, S.; Montenegro-Venegas, C.; Pina-Fernández, E.; Marini, C.; et al. "Erratum: Correction: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy (PLoS genetics (2017) 13 3 (e1006684))". PLoS genetics 13 6 (2017): e1006843-e1006843. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054771599&partnerID=MN8TOARS. Acesso aberto • 10.1371/journal.pgen.1006843 D'Amico, Davide; Gener, Thomas; de Lagrán, Maria Martínez; Sanchez-Vives, Maria V; Santos, Mónica; Dierssen, Mara. "Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear". Neuropsychopharmacology 42 2 (2016): 462-472. http://dx.doi.org/10.1038/npp.2016.154. Acesso aberto • Publicado • 10.1038/npp.2016.154 Foote, Molly; Arque, Gloria; Berman, Robert F.; Santos, Mónica. "Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in Mice". The Cerebellum 15 5 (2016): 611-622. http://dx.doi.org/10.1007/s12311-016-0797-6. Publicado • 10.1007/s12311-016-0797-6 Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu, Nuria; Dierssen, Mara; Fillat, Cristina. "Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges". BMC Genomics 16 1 (2015): http://dx.doi.org/10.1186/s12864-015-2160-6. Acesso aberto • Publicado • 10.1186/s12864-015-2160-6 Santos, Mónica; D’Amico, Davide; Dierssen, Mara. "From neural to genetic substrates of panic disorder: Insights from human and mouse studies". European Journal of Pharmacology 759 (2015): 127-141. http://dx.doi.org/10.1016/j.ejphar.2015.03.039. Publicado • 10.1016/j.ejphar.2015.03.039 Fillat, C.; Bofill-De Ros, X.; Santos, M.; Martín, E.D.; Andreu, N.; Villanueva, E.; D'Amico, D.; Dierssen, M.; Altafaj, X.. "Identification of key genes involved in Down syndrome pathogenesis by gene therapy,Identificación de genes clave implicados en el síndrome de Down mediante terapia génica". SD Revista Medica Internacional sobre el Sindrome de Down 18 2 (2014): 21-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940262370&partnerID=MN8TOARS. Publicado • 10.1016/S1138-2074(14)70049-1 Santos, M.; D'Amico, D.; Spadoni, O.; Amador-Arjona, A.; Stork, O.; Dierssen, M.. "Hippocampal Hyperexcitability Underlies Enhanced Fear Memories in TgNTRK3, a Panic Disorder Mouse Model". Journal of Neuroscience 33 38 (2013): 15259-15271. http://dx.doi.org/10.1523/jneurosci.2161-13.2013. Publicado • 10.1523/jneurosci.2161-13.2013 Temudo, Teresa; Santos, Mónica; Ramos, Elisabete; Dias, Karin; Vieira, José Pedro; Moreira, Ana; Calado, Eulália; et al. "Rett syndrome with and without detected MECP2 mutations: An attempt to redefine phenotypes". Brain and Development 33 1 (2011): 69-76. http://dx.doi.org/10.1016/j.braindev.2010.01.004. Publicado • 10.1016/j.braindev.2010.01.004 Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al. "Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome". Neuroscience 170 2 (2010): 453-467. http://dx.doi.org/10.1016/j.neuroscience.2010.07.010. Publicado • 10.1016/j.neuroscience.2010.07.010 Santos, Mónica; Temudo, Teresa; Kay, Teresa; Carrilho, Inês; Medeira, Ana; Cabral, Helena; Gomes, Roseli; et al. "Mutations in the MECP2 Gene Are Not a Major Cause of Rett Syndrome-Like or Related Neurodevelopmental Phenotype in Male Patients". Journal of Child Neurology 24 1 (2009): 49-55. http://dx.doi.org/10.1177/0883073808321043. Publicado • 10.1177/0883073808321043 Carvalho, A.; Santos, M.; Maciel, P.; Rodrigues, F.. "T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population". Multiple Sclerosis Journal 14 4 (2008): 550-552. http://dx.doi.org/10.1177/1352458507084594. Publicado • 10.1177/1352458507084594 Ferro, Anabela; Castro, Maria-José; Lemos, Carolina; Santos, Mónica; Sousa, Alda; Pereira-Monteiro, José; Sequeiros, Jorge; Maciel, Patrícia. "The C677T Polymorphism inMTHFRIs Not Associated with Migraine in Portugal". Disease Markers 25 2 (2008): 107-113. http://dx.doi.org/10.1155/2008/178679. Publicado • 10.1155/2008/178679 Santos, Mónica; Yan, Jin; Temudo, Teresa; Oliveira, Guiomar; Vieira, José Pedro; Fen, Jinong; Sommer, Steve; Maciel, Patrícia. "Analysis of Highly Conserved Regions of the 3’UTR of MECP2 Gene in Patients with Clinical Diagnosis of Rett Syndrome and Other Disorders Associated with Mental Retardation". Disease Markers 24 6 (2008): 319-324. http://dx.doi.org/10.1155/2008/738401. Publicado • 10.1155/2008/738401 Venâncio, Margarida; Santos, Mónica; Pereira, Susana Aires; Maciel, Patrícia; Saraiva, Jorge M. "An explanation for another familial case of Rett syndrome: maternal germline mosaicism". European Journal of Human Genetics 15 8 (2007): 902-904. http://dx.doi.org/10.1038/sj.ejhg.5201835. Publicado • 10.1038/sj.ejhg.5201835 Temudo, T.; Oliveira, P.; Santos, M.; Dias, K.; Vieira, J.; Moreira, A.; Calado, E.; et al. "Stereotypies in Rett syndrome: Analysis of 83 patients with and without detected MECP2 mutations". Neurology 68 15 (2007): 1183-1187. http://dx.doi.org/10.1212/01.wnl.0000259086.34769.78. Publicado • 10.1212/01.wnl.0000259086.34769.78 Santos M; Silva-Fernandes A; Oliveira P; Sousa N; Maciel P; Santos, M.; Silva-Fernandes, A.; et al. "Evidence for abnormal early development in a mouse model of Rett syndrome.". Genes, Brain and Behavior 6 3 (2007): 277-286. http://europepmc.org/abstract/med/16848781. Publicado • 10.1111/j.1601-183X.2006.00258.x Coutinho, Ana M.; Oliveira, Guiomar; Katz, Cécile; Feng, Jinong; Yan, Jin; Yang, Chunmei; Marques, Carla; et al. "MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B 4 (2007): 475-483. http://dx.doi.org/10.1002/ajmg.b.30490. Publicado • 10.1002/ajmg.b.30490 Ban, M.; Booth, D.; Heard, R.; Stewart, G.; Goris, A.; Vandenbroeck, K.; Dubois, B.; et al. "Corrigendum to "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans" [J. Neuroimmunol. 179 (2006) 108-116] (DOI:10.1016/j.jneuroim.2006.06.003)". Journal of Neuroimmunology 189 1-2 (2007): 175-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548554091&partnerID=MN8TOARS. Acesso aberto • 10.1016/j.jneuroim.2007.08.003 The GAMES Collaborative Group. "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans". Journal of Neuroimmunology 179 1-2 (2006): 108-116. http://dx.doi.org/10.1016/j.jneuroim.2006.06.003. Publicado • 10.1016/j.jneuroim.2006.06.003 Santos, M.; Coelho, P. A.; Maciel, P.. "Chromatin remodeling and neuronal function: exciting links". Genes, Brain and Behavior 5 (2006): 80-91. http://dx.doi.org/10.1111/j.1601-183x.2006.00227.x. Publicado • 10.1111/j.1601-183x.2006.00227.x Burwick, R. M.; Ramsay, P. P.; Haines, J. L.; Hauser, S. L.; Oksenberg, J. R.; Pericak-Vance, M. A.; Schmidt, S.; et al. "APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers". Neurology 66 9 (2006): 1373-1383. http://dx.doi.org/10.1212/01.wnl.0000210531.19498.3f. Publicado • 10.1212/01.wnl.0000210531.19498.3f Shi, Jinxiu; Shibayama, Akane; Liu, Qiang; Nguyen, Vu Q.; Feng, Jinong; Santos, Monica; Temudo, Teresa; Maciel, Patricia; Sommer, Steve S.. "Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR)". Human Mutation 25 5 (2005): 505-505. http://dx.doi.org/10.1002/humu.9338. Publicado • 10.1002/humu.9338 Santos, Mónica; do Carmo Costa, Maria; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; et al. "Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin". Multiple Sclerosis Journal 10 2 (2004): 153-157. http://dx.doi.org/10.1191/1352458504ms998oa. Publicado • 10.1191/1352458504ms998oa Santos, M.; Pinto-Basto, J.; Rio, M.E.; Sá, M.J.; Valença, A.; Sá, A.; Dinis, J.; et al. "A whole genome screen for association with multiple sclerosis in Portuguese patients". Journal of Neuroimmunology 143 1-2 (2003): 112-115. http://dx.doi.org/10.1016/j.jneuroim.2003.08.023. Publicado • 10.1016/j.jneuroim.2003.08.023
Poster em conferência	Ferrer PS,; Pardo-Garcia, Josep; Martínez-Rodríguez E, ; Santos, M; Enrique Lanuza; Agustín-Pavón, Carmen. Autor correspondente: Agustín-Pavón, Carmen. "MeCP2 deficiency impairs the maturation process of doublecortin neurons in the olfactory cortex". Trabalho apresentado em 11th IBRO World Congress of Neuroscience, 2023. Primo Hernando, L; Martínez-Rodríguez E, ; Santos, M; Agustín-Pavón, Carmen; Torres-Pérez, JV. "Impact of an early-life adverse experience on microglia activation in the periaquedutal gray of adolescent Mecp2-heterozygous female mice". Trabalho apresentado em 11th IBRO World Congress of Neuroscience, 2023. Masella, Gianluca; Silva, Francisca; Mele, M; Duarte, Carlos B.; Santos, M. "NT-3/TrkC-dependent regulation of NMDA receptors: implications for fear extinction". Trabalho apresentado em ISN-ESN Meeting, 2023. Masella, Gianluca; Francisca Silva; Corti, Elisa; Madeira, Maria Francisca; Ferreira, Samira G.; Tomé, Angelo R.; Rodrigo A. Cunha; Carlos B. Duarte; Santos, Monica. "NT3/TrkC signaling regulate contextual fear extinction and amygdalar long-term potentiation, with a mechanism dependent on GluN2B subunit of NMDA receptors". Trabalho apresentado em ISN-ESN 2023 Meeting, 2023. Madeira, Maria Francisca; Masella, Gianluca; Silva, Francisca; Leitão, Ricardo; Abellán-Álvaro, Maria; Teruel, A.; Agustín-Pavón, Carmen; Santos, Mónica. "Early-life stress and MeCP2 interaction effects on anxiety neurocircuitry". Trabalho apresentado em FENS Regional Meeting, 2023. Rodrigues, Beatriz; Leitão, Ricardo Alexandre; Santos, Monica; Silva, Mariline; Paulo César Silva Pinheiro; Carvalho, Ana Luisa. "REGULATION OF PFC SYNAPTIC FUNCTION AND BEHAVIOR BY CHRONIC STRESS-INDUCED MICRORNA-186-5P". Trabalho apresentado em FENS Regional meeting 2023, 2023. Masella, Gianluca; Francisca Silva; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Autor correspondente: Santos, Monica. "Neurotrophin-3/TrkC contribution to fear extinction and regulation of glutamatergic synapses". Trabalho apresentado em FENS Forum 2022, 2022. Francisca Silva ; Masella, Gianluca; Elena Martínez-Rodríguez; Andretta, Emanuela; Mele, Miranda; Duarte, Carlos B.. "Role of NT3/TrkC in the regulation of fear.". Trabalho apresentado em 13th Symposium of Bial Foundation “Behind and Beyond the Brain”, 2022. Francisca Silva ; Masella, Gianluca; Elena Martínez-Rodríguez; Santos, Monica. Autor correspondente: Santos, Monica. "Amygdalar TrkC activation is associated with successful fear extinction performance". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Masella, Gianluca; Andretta, Emanuela; Mele, Miranda; Duarte, Carlos B.; Santos, Monica. Autor correspondente: Santos, Monica. "NT3/TrkC signaling controls the composition and the synaptic abundance of AMPA and NMDA receptors.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Santos, Monica; María Abellán-Álvaro; Stork, O; Agustín-Pavón, Carmen. Autor correspondente: Santos, Monica. "MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Elena Martínez-Rodríguez; Anabel Forte; Enrique Lanuza; Santos, Monica; Agustín-Pavón, Carmen. Autor correspondente: Agustín-Pavón, Carmen. "Maternal separation decreases the expression of doublecortin in the olfactory system of both Mecp2-heterozygous female mice and their healthy controls.". Trabalho apresentado em 19th Meeting of the Spanish Society for Neuroscience, 2021. Sevilla-Ferrer, Paloma; Pardo-Garcia, Josep; Elena Martínez-Rodríguez; María Abellán-Álvaro; Santos, Monica; Enrique Lanuza; Agustín-Pavón, Carmen. Autor correspondente: Agustín-Pavón, Carmen. "The increase in doublecortin immature neurons in the olfactory cortex is linked to symptom onset in a mouse model of Rett syndrome.". Trabalho apresentado em 19th Meeting of the Spanish Society for Neuroscience, 2021. Caliskan, Gursel; Kul, Emre; Hukema, Renate K.; Willemsen, Rob; Santos, Monica; Oliver Stork. Autor correspondente: Oliver Stork. "Heightened anxiety and ventral hippocampal gamma oscillations in an inducible mouse model of FMR1 premutation". Trabalho apresentado em FENS virtual Forum, 2020. Martínez-Rodríguez, Elena; Foiani, Cristina; Martín-Sánchez, Ana; Martínez-Garcia, Fernando; Lanuza, Enrique; Santos, M; Agustín-Pavón, Carmen. "Postnatal neurogenesis in the olfactory bulbs of a mouse model of Rett syndrome". Trabalho apresentado em 2nd symposium of the Spanish Network of Adult Neurogenesis (RENA), 2019. Kul, Emre; Hukema, Renate K.; Willemsen, Rob; Santos, M; Stork, Oliver. "Progression of FXTAS Reveals Sensorimotor Deficiencies upon Extended Expression of the CGG-Premutation". Trabalho apresentado em 11th FENS Forum of Neuroscience, 2018. Kul, Emre; Castro, Hoanna; Deipenbrock, Leandra; Ribeiro, Juliana; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; et al. "Critical Time Windows of Premutation Expression in FXTAS Phenotype.". Trabalho apresentado em 10th FENS Forum of Neuroscience, 2016. Santos, M; D'Amico, Davide; Gener, Thomas; Sanchez-Vives, M. V.. "Infralimbic NT3 infusion restores fear extinction memory impairment in a mouse model of panic disorder". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neuroscience, 2015. Santos, M; D'Amico, Davide; Gener, Thomas; Sanchez-Vives, M. V.; Dierssen, Mara. "Infralimbic NT3 infusion restores fear extinction memory impairment in a mouse model of panic disorder". Trabalho apresentado em International Meeting of Learning and Memory: Cellular and Systemic Views, 2015. Santos, M; D'Amico, Davide; Dierssen, Mara. "Altered hippocampus-dependent cognitive profile and fear circuit activation in a transgenic mouse that overexpresses TrkC: insight on panic disorder". Trabalho apresentado em ESF-FENS conferences on The Dynamic Brain: The Neurobiology of Emotion, 2012. Santos, M; D'Amico, Davide; Padrell, Sara; Dierssen, Mara. "In vivo TrkC overexpression induces hyperexcitability and strengthens hippocampus-dependent fear memories". Trabalho apresentado em 8th FENS Forum of Neuroscience, 2012. Santos, M; D'Amico, Davide; Vegue, Marina; Dierssen, Mara. "Hippocampal overexcitability in a panic disorder mouse model.". Trabalho apresentado em 40th Society for Neuroscience, 2010. Molas, Susanna; Gallego, Xavier; Santos, M; Dierssen, Mara. "A mouse model for nicotine dependence: The overexpression of the human genomic cluster CHRNA3/A5/B4". Trabalho apresentado em 7th FENS Forum of Neuroscience, 2010. D'Amico, Davide; Santos, M; Spadoni, Ornella; Dierssen, Mara. "Hippocampal alterations associated with fear memories in TgNTRK3 mouse, a model of panic disorder". Trabalho apresentado em EMBL Workshop on Translating Behaviour: Bridging Clinical and Animal Model Research, 2009. Molas, Susanna; Gallego, Xavier; Santos, M; Dierssen, Mara. "The implication of nicotine in anxious behaviour and cognition converge on the human genetic cluster CHRNA3/CHRNA5/CHRNB4: evidences from a transgenic model". Trabalho apresentado em VII Experimental Biology Symposium, 2008. Santos, M; Teixeira-Castro, Andreia; Silva-Fernandes, Anabela; Tavares, Hugo; Sousa, Nuno; Maciel, Patrícia. "Absence of MeCP2 increases postnatal dentate gyrus cell proliferation in a mouse model of Rett syndrome.". Trabalho apresentado em 6th FENS Forum of European Neuroscience, 2008. Santos, M; Coutinho, A. M.; Yan, Jin; Yang, C; Feng, J; Vicente, Astrid; Sommer, Steve S.; Maciel, Patrícia. "Analysis of the 3’ UTR of the MECP2 gene in patients with clinical diagnosis of Rett syndrome and mental retardation". Trabalho apresentado em 56th annual meeting of The American Society of Human Genetics, 2006. Santos, M; Temudo, Teresa; Carrilho, Isabel; Gaspar, I; Barbot, Clara; Medeira, Ana; Cabral, Helena; et al. "Genetic study of boys with a Rett syndrome-like phenotype: analysis of the MECP2, NLGN3 and NLGN4 genes.". Trabalho apresentado em 7th Annual Rett syndrome Symposium, 2006. Santos, M; Venâncio, Margarida; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "P56. Genetic study of boys with a Rett syndrome-like phenotype: analysis of the MECP2, NLGN3 and NLGN4 genes". Trabalho apresentado em 9th Annual Meeting of the Portuguese Society of Human Genetics, 2005. Santos, M; Temudo, Teresa; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "P2727, 489. Male patients with Rett-like phenotype do not present mutations in the MECP2, NLGN3 and NLGN4 genes". Trabalho apresentado em 54th Annual Meeting of The American Society of Human Genetics, 2004. Temudo, Teresa; Santos, M; Dias, Karen; Barbot, Clara; Cabral, P.; Moreira, Ana; Carrilho, Isabel; et al. "P2728, 489. Genotype-phenotype correlations in portuguese patients with Rett syndrome". Trabalho apresentado em 54th Annual Meeting of The American Society of Human Genetics, 2004. Temudo, Teresa; Santos, M; Dias, Karen; Barbot, Clara; Cabral, P.; Moreira, Ana; Carrilho, Isabel; et al. "Genotype-phenotype correlations in portuguese patients with Rett syndrome". Trabalho apresentado em 54th Annual Meeting of The American Society of Human Genetics, 2004. Santos, M; Temudo, Teresa; Barbot, Clara; Medeira, Ana; Cabral, Helena; Cabral, P.; Carrilho, Isabel; et al. "Male patients with Rett-like phenotype do not present mutations in the MECP2, NLGN3 and NLGN4 genes". Trabalho apresentado em 54th Annual Meeting of The American Society of Human Genetics, 2004. Ferro, Anabela; Castro, Maria-José; Sousa, Alda; Lemos, Carolina; Santos, M; Silveira, Isabel; Pereira-Monteiro, J.; Sequeiros, Jorge. "P16. The C677T MTHFR polymorphism is not a genetic risk factor for migraine in the portuguese population". Trabalho apresentado em Genetics of complex traits and isolated populations, 2003. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "P0913. Susceptibility and disease progression in Portuguese patients with multiple sclerosis: study of the role of APOE and SCA2 loci". Trabalho apresentado em European Congress of Human Genetics, 2002. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "Susceptibility and disease progression in Portuguese patients with multiple sclerosis: study of the role of APOE and SCA2 loci". Trabalho apresentado em European Congress of Human Genetics, 2002. Santos, M; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, M.C.; Valença, A.; Sá, André; et al. "P01.138. Study of the APOE and SCA2 loci in multiple sclerosis patients of Portuguese origin". Trabalho apresentado em 54th Annual Meeting of the American Academy of Neurology, 2002. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "Identification of 3 new intragenic polymorphisms in the MJD1 gene and study of its frequency in the portuguese population". Trabalho apresentado em 5th Annual Meeting of the Portuguese Society of Human Genetics, 2001. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "P1373. Identification of three novel polymorphisms in the MJD1 gene and their frequency study in a Portuguese population". Trabalho apresentado em 51st Annual Meeting of The American Society of Human Genetics, 2001. Costa, Maria do Carmo; Santos, Cláudia; Ferro, Anabela; Santos, M; Sequeiros, Jorge; Maciel, Patrícia. "Identification of three novel polymorphisms in the MJD1 gene and their frequency study in a Portuguese population". Trabalho apresentado em 51st Annual Meeting of The American Society of Human Genetics, 2001.
Pré-impressão	Gianluca Masella; Francisca Silva; Elisa Corti; Garokoitz Azkona; Maria Francisca madeira; Ângelo Tomé; Samira Ferreira; et al. "Amygdalar NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". 2023. https://doi.org/10.21203/rs.3.rs-3059690/v1. 10.21203/rs.3.rs-3059690/v1 Ana Luisa Carvalho; Beatriz Rodrigues; Ricardo Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela Inácio; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". 2023. https://doi.org/10.21203/rs.3.rs-3405749/v1. 10.21203/rs.3.rs-3405749/v1
Resumo em conferência	Martínez-Rodríguez, Elena; Andretta, Emanuela; Mele, Miranda; Santos, M. "Role of NT3-TrkC in the regulation of fear". Trabalho apresentado em 2020 BIAL Foundation symposium - Behind and Beyond the Brain, Porto, 2020. Pinto-Basto, José; Santos, Mónica; Rio, Maria Edite; Sá, MJ; Valença, Ângela; Sá, Alfredo; Dinis, José; et al. "Rastreio do genoma e identificação de loci associados à esclerose múltipla em doentes portugueses". Trabalho apresentado em Congresso de Neurologia, Espinho, 2002. Publicado Santos, Mónica; Costa, MC; Rio, Maria Edite; Sá, MJ; Carvalho, Marta; Valença, Ângela; Sá, Alfredo; et al. "Susceptibilidade e progressão da esclerose múltipla em doentes Portugueses - estudo do papel dos loci APOE e SCA2". Trabalho apresentado em Congresso de Neurologia, Espinho, 2002. Publicado Santos, Mónica; Costa, MC; Rio, Maria Edite; Sá, MJ; Carvalho, Marta; Valença, Ângela; Sá, Alfredo; et al. "Study of the ApoE and SCA2 Loci in Multiple Sclerosis Patients of Portuguese Origin". Trabalho apresentado em 54th Annual Meeting of AAN, Denver, 2002. Publicado
Tese / Dissertação	Santos, Mónica Joana Pinto dos. "Pathogenesis of Rett syndrome and study of the role of MeCP2 protein in neuronal function.". Doutoramento, 2007. http://hdl.handle.net/10216/7217.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/11/17	NT3-TrkC System in the Regulation of Fear Memories.	Institute of Neuroscience Seminars Institute of Neuroscience, Autonomous University of Barcelona (Barcelona, Espanha)
2023/10/30	NT3-TrkC System in the Regulation of Fear Memories.	Cajal Course Advance Techniques in Synapse Biology Cajal Course (Bordeaux, França)
2023/10/18	The Science Behind Fear Memories.	DCV talks Department of Life Sciences, Faculty of Science and Technology, University of Coimbra (Coimbra, Portugal)
2023/04/15	A Ciência por Detrás do Medo \| The Science Behind Fear	meet.Lab Associação de Estudantes de Biologia (Coimbra, Portugal)
2018/05/10	Lack of MeCP2 leads to na increase of immature neurons in the olfactory system.	VII Olfactory Journeys Spanish Olfactory Network (La Franca, Espanha)
2016/04/15	Critical Time Windows of Premutation Expression: FXTAS and Other Phenotypes.	Research Seminars in Biomedicine Universitat Jaume I (Castelló de la Plana, Espanha)
2016/03/04	Role of the NT3/TrkC system in the formation and extinction of (pathological) fear memories.	CNC weekly seminars Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2015/10/16	Critical Time Windows of Premutation Expression: FXTAS and Other Phenotypes	CNC weekly seminars Universidade de Coimbra Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2015/10/01	Behavioral characterization of an inducible mouse model of FXTAS: critical time windows of premutation expression.	2nd FMR1 premutation meeting (Sitges, Espanha)
2014/12/18	Role of the NT3/TrkC system in the formation and extinction of (pathological) fear memories.	Neuroscience seminars Life and Health Sciences Research Institute (ICVS) (Braga, Portugal)
2013/05/31	Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.	XIII Meeting of the Portuguese Society for Neuroscience Portuguese Society for Neuroscience (Luso, Portugal)
2013/03/01	Antagonizing HSA21-synthenic miRNAs effects in the Ts65Dn mouse model of Down syndrome by a lentiviral miRNA sponge strategy.	VI CIBERER Annual Meeting CIBERER (San Lorenzo del Escorial, Espanha)
2013/02/26	Contribution of the hippocampus to exaggerated fear in TgNTRK3, a mouse model of panic disorder.	Neuroscience seminars Leibniz Institute (Magdeburg, Alemanha)
2009/09/15	Understanding the Impact of Panic Attacks on Brain Systems Involved in the Pathophysiology of Panic Disorder.	XII Meeting of the Spanish Society for Neuroscience Spanish Society for Neuroscience (Tarragona, Espanha)
2009/03/08	Characterization of the hippocampal microcircuit in a mouse model of panic disorder.	5th Cajal Winter Conference Spanish Society for Neurosciences (Benasque, Espanha)
2008/10/10	Age- and region-specific disturbances of monoaminergic systems in the brain of MECP2-null mice.	6th World Rett Syndrome Congress Rett syndrome Research Foundation (Paris, França)
2008/03/03	Delayed achievement of developmental milestones in a mouse model of Rett syndrome.	4th Cajal Winter Conference Spanish Society of Neuroscience (Benasque, Espanha)
2005/11/15	Delayed achievement of developmental milestones in a mouse model of Rett syndrome.	35th Annual meeting of the Society for Neuroscience Society for Neuroscience (Washington, Estados Unidos)
2005/10/13	Rett syndrome-like male patients: study of the MECP2, NLGN3 and NLGN4 genes.	2nd Iberian Meeting of Neuropediatrics IV Meeting of the Portuguese Society of Neuropediatrics (Estoril, Portugal)
2005/10/13	Study of postnatal neurodevelopmental hallmarks in a mouse model of Rett syndrome.	2nd Iberian Meeting of Neuropediatrics IV Meeting of the Portuguese Society of Neuropediatrics (Estoril, Portugal)
2002/10/15	Association study of multiple sclerosis in Portuguese patients: whole genome screen using 6,000 microsatellite markers.	52nd Meeting of American Society of Human Genetics American Society of Human Genetics (Baltimore, Estados Unidos)
2002/10/07	Genome screen and identification of loci associated to multiple sclerosis in Portuguese patients.	Congress of Neurology Portuguese Society of Neurology (Espinho, Portugal)
2002/10/07	Susceptibility and progression of multiple sclerosis in portuguese patients - study of the role of APOE and SCA2 loci.	Congress of Neurology Portuguese Society of Neurology (Espinho, Portugal)
2002/04/12	Candidate gene studies in Portuguese patients	Genetic Analysis of Multiple Sclerosis in Europeans (GAMES) Meeting GAMES consortium (Istanbul, Turquia)
2001/11/16	Clinical, Epidemiological and Genetic study of Rett syndrome in Portugal	Congress of Neurology Portuguese Society of Neurology (Lisboa, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2024 - Atual	The effects of early-life stress and MeCP2 interaction on neurobehavior. Bachelor in Cell and Molecular Biology, Department of Life Sciences. Orientador	Cell and Molecular Biology (Licenciatura/Bacharelato) Universidade Nova de Lisboa, Portugal
2024 - Atual	Validation of small molecule TrkC agonists in vitro in cultured cortical neurons. Orientador	Biology (Licenciatura/Bacharelato) Universidade de Coimbra, Portugal
2023/09/01 - Atual	Early-life stress influence on anxiety neurocircuitry and behavior: the contribution of MeCP2. Orientador	Neurociências (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - Atual	Modulation of fear extinction by social hierarchy: behaviour, neuronal circuits and epigenetics Orientador	Neurociências (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09/01 - Atual	NT3-TrkC system in contextual fear extinction and in the regulation of glutamatergic synapses Orientador de Gianluca Masella	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/01 - 2024/02/26	NT3-TrkC system in the regulation of GABAergic synapses and inhibition/excitation balance. Orientador	Neurobiologia (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09/01 - 2022/09/16	The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2 Orientador de Maria Francisca Madeira	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/01 - 2021/12/21	Dissection of NT3/TrkC intracellular signaling in the processing of fear Orientador de Francisca Silva	Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02/01 - 2021/06/30	To investigate the contribution of neurotrophins to the aberrant maturation in the olfactory system of Mecp2-mutant mice Orientador de João Videira	Biology (Licenciatura/Bacharelato) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/03 - 2020/12/18	Role of NT3-TrkC in fear learning and in the regulation of glutamatergic synapses Orientador de Gianluca Masella	Neuroscience (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Università degli Studi di Trieste, Itália
2015 - 2020	Reversibility of the pathology in a mouse model of Fragile X-associated tremor/ataxia syndrome: exploring time-dependence and intervention strategies. Coorientador de Emre Kul	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2014 - 2017	Characterization of postnatal neurodevelopment and behavioural cognition of a noonan syndrome mouse model. Coorientador de Maisaloon Sader	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha University of Haifa, Israel
2015 - 2016	Dissecting the role of MECP2 mutations: molecular tools and behavioural analysis. Coorientador de Leandra Deipenbrok	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha Universität Potsdam, Alemanha
2013 - 2013	Phenotype rescue in a down syndrome mouse model using a miRNA decoy method. Coorientador de Victoria Brugada	Universitat Pompeu Fabra, Espanha Centro de Regulación Genómica, Espanha
2009 - 2013	Fear memories in TgNTRK3 mice, a model of panic disorder: definition of mechanism and search for new therapeutical targets. Coorientador de Davide D'Amico	Universitat Pompeu Fabra, Espanha Centro de Regulación Genómica, Espanha
2008 - 2009	Understanding the impact of panic attacks on brain systems involved in the pathophysiology of panic disorder. Coorientador de Ornella Spadoni	Centro de Regulación Genómica, Espanha Università degli Studi di Roma La Sapienza, Itália

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2019/12/20 - Atual	Science with Books (Ciência com livros): What am I made of? Organs, Cells, Genes. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing their curiosity and critical thinking. (2019/12/20 - 2019/12/20) Oficina (workshop) (Coorganizador)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2019/10/26 - Atual	Science with Books (Ciência com livros): Me and only me. DNA and the world around me. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing their curiosity and critical thinking. (2019/10/26 - 2019/10/26) Oficina (workshop) (Coorganizador)	Biblioteca Municipal de Santa Maria da Feira, Portugal Biblioteca de Santa Maria da Feira, Portugal
2019 - Atual	Science with Books (Ciência com livros): My brain and Our senses. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing curiosity and critical thinking. (2019/04/16 - 2019/04/17) Oficina (workshop) (Coorganizador)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2019 - Atual	Science with Books (Ciência com livros): Colors. Aims at disseminate and promote scientific culture among 1st and 2nd grade kids, flourishing curiosity and critical thinking. (2021/02/20 - 2021/02/20) Oficina (workshop) (Coorganizador)	Biblioteca Municipal de Santa Maria da Feira, Portugal
2022/04/06 - 2022/04/06	Mini-symposium: Animal Welfare meets the Bench. (2022/04/06 - 2022/04/06) Simpósio (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/01/23 - 2020/01/24	Mini-symposium: The Neurobiology of Socio-Sexual Behavior. (2020/01/23 - 2020/01/24) Simpósio (Coorganizador)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2009	In vivo models and tools in neuroscience research. (2009/09/16 - 2009/09/19) Oficina (workshop) (Presidente da Comissão Organizadora)	Spanish Neuroscience Society, Espanha

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2024/01/17 - 2024/01/17	Lecture to high school students (13-14 years) in the scope of the discipline 'Development and Citizenship'. Seminário	The effect of psychoactive substances in the brain Agrupamento de escolas do Cavaco, Portugal
2024/01/04 - 2024/01/04	Lecture for high school students (13-14 years) in the scope of the Discipline 'Development and Citizenship' Seminário	The effect of psychoactive substances in the brain Agrupamento de escolas da Corga do Lobão, Portugal
2021/02/20 - 2021/02/20	Public Outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Oficina (workshop)	Science with books (Ciência com livros): Colors Biblioteca Municipal de Santa Maria da Feira, Portugal
2019/12/20 - 2019/12/20	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Oficina (workshop)	Science with books (Ciência com livros): What am I made of: organs, cells, genes. Biblioteca de Santa Maria da Feira, Portugal
2019/11/25 - 2019/11/25	Public outreach. Hands on science activities at a 1st grade school Outro	Science and Technology week Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/10/26 - 2019/10/26	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Oficina (workshop)	Science with books (Ciência com livros): The one and only me. DNA and the world around me Biblioteca de Santa Maria da Feira, Portugal
2019/04/17 - 2019/04/17	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Oficina (workshop)	Science with books (Ciência com livros): Our senses Biblioteca de Santa Maria da Feira, Portugal
2019/04/16 - 2019/04/16	Public outreach. Workshop series with experiments and hands on activities directed to 1st grade kids. Oficina (workshop)	Science with books (Ciência com livros): Our brain Biblioteca de Santa Maria da Feira, Portugal
2012/06/18 - 2012/06/18	Public outreach. What is Neuroscience? From its beginnings to the latest discoveries. Seminário	Cultural week at La Verneda adult's school Centre de Formació d'Adults La Verneda, Espanha
2011/10/11 - 2011/10/11	Soft skills. Team management and leadership training for a successful scientific career. Oficina (workshop)	Leading for Success in Science, refresher day Parc de Recerca Biomèdica de Barcelona, Espanha
2010/06/03 - 2010/06/04	Continuous formation. Introductory course to electrophysiology techniques. Outro	1st Introductory course to electrophysiology techniques: E2 and MEAs Aleria Biodevices, Espanha
2010/05/08 - 2010/05/10	Soft skills. Team management and leadership training for a successful scientific career. Oficina (workshop)	Leading for Success in Science Parc de Recerca Biomèdica de Barcelona, Espanha
2010/03/12 - 2010/03/12	Public outreach. Seminar on Neuroscience at a 1st grade school. Seminário	Brain Awareness Week Spanish Society of Neuroscience, Espanha
2010 - 2010	Public outreach. Event to raise funding for rare diseases Concerto	One in a Million Centro de Regulación Genómica, Espanha
2010 - 2010	Public outreach. Fair on brain-related experiments Exposição	Brain fair mNACTEC Museum, Espanha
2010 - 2010	Public outreach. Neuromarketing: how marketing influences our choices. Exposição	Neuromarketing: the brain and decision-making, Centro de Regulación Genómica, Espanha
2009/11/10 - 2009/11/11	Soft skills. Course on how to improve competence and confidence when presenting at biomedical conferences.. Oficina (workshop)	Conference presentation skills Parc de Recerca Biomèdica de Barcelona, Espanha
2009/03 - 2009/03	Public outreach. Fair on brain-related experiments. Exposição	The illusions of the brain (Las ilusiones del Cerebro) Centro de Regulación Genómica, Espanha
2008/12 - 2008/12	Public outreach. Fair on brain-related experiments Exposição	Brain fair Centro de Regulación Genómica, Espanha
2008/04 - 2008/04	Public outreach. Workshops on brain-related experiments Exposição	Museums night (Nits dels Museus) Cosmocaixa Barcelona, Espanha
2007/07/17 - 2007/07/21	Continuous formation. I attended a series of seminars in cognition. Conferência	Neuroscience Summer Seminars. Cognition: From Genes to Function Duques de Soria Foundation, Espanha
2007/02/14 - 2007/02/16	Continuous formation. I attended a workshop on behaviour pathologies. Oficina (workshop)	IGC workshop series. Behaviour pathologies: Biological Approaches Instituto Gulbenkian de Ciência, Portugal
2005/02/19 - 2005/02/19	Public outreach. Rett syndrome: What the genes tell us. Seminário	Annual meeting of ANPAR Associação Nacional de Pais e Amigos de Rett (ANPAR), Portugal
2004/07/19 - 2004/07/23	Continuous formation. I attended a postgraduate course on Genes and Neurons. Outro	Postgraduate courses. Genes and Neurons Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/06/03 - 2004/06/04	Continuous formation. I attended a workshop on rodent behaviour testing. Oficina (workshop)	Introduction to rodent behaviour testing Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2003/10/29 - 2003/10/31	Continuous formation. I attended a workshop on laboratory safety. Oficina (workshop)	Segurança laboratorial: Biológica, Química e Radiológica Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/06/25 - 2003/06/27	Continuous formation. I attended a postgraduate course on cell and tissue culture techniques. Outro	Postgraduate courses: Cell and tissue culture techniques Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/05/29 - 2003/05/30	Continuous formation. I attended a postgraduate course on microscopy Outro	Postgraduate course: Light microscopy and advanced imaging, principles and good practice Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002/09/15 - 2002/09/22	Continuous formation. I attended a practical course on mouse anatomy and embryology. Outro	EMBO practical course: Anatomy and Embryology of the Mouse University of Zagreb Faculty of Medicine, Croácia
2002/06/05 - 2002/06/07	Continuous formation. I attended a postgraduate course on microscopy Outro	Postgraduate course: Light microscopy and analysis: principles and good practice, including recording images from the microscope Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002/03/01 - 2002/03/01	Soft skills. I attended a workshop on ethics in animal experimentation. Oficina (workshop)	Responsible science: Animal experimentation today and in the future. Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/08/13 - 2001/08/31	Continuous formation. I attended the Erasmus Summer Programme on Medical Genetics. Outro	Erasmus Summer Programme Erasmus MC, Países Baixos
2001/05/21 - 2001/05/25	Continuous formation. I attended the a course on gene mapping. Outro	Human Disease Gene Mapping Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/03/25 - 2001/03/31	Continuous formation. I attended a course in Medical Genetics Outro	14th Course in Medical Genetics European School of Genetic Medicine, Itália

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/09/25	Stressors in epilepsy: impact of cognition, quality of life and social function. Arguente principal	Judit Catalan (Doutoramento) Universitat de València, Espanha
2024/01/16	Interneuron characterization in Rett Syndrome: insights from mice prefrontal cortex Arguente principal	Isabella Oliveira (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2023/09/18	Dissecting the role of adenosine A2A receptors on neurobehavioral deficits induced by binge-like exposure to ethanol during adolescence. Master in Cellular and Molecular Biology Arguente principal	Madalena Piteira (Mestrado) Universidade de Coimbra, Portugal
2022/05	Role of extracelular vesicles in cognitive and motor decline in hyperammonemia and hepatic encephalopathy. Molecular mechanisms and therapeutic implications. Arguente principal	Paula Izquierdo (Doutoramento) Universitat de València, Espanha Fundación de la Comunidad Valenciana Centro de Investigación Príncipe Felipe, Espanha
2020/07/24	Alloparental behavior: the effect of pup exposure on nest building and the role of serotonin. Arguente principal	Catarina Pacheco (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Institut du Cerveau et de la Moelle Épinière, França
2020/01/31	The medial amygdala as a key neural centre in maternal aggression. Vogal	Maria Abellán Álvaro (Doutoramento) Universitat de Valencia Facultat de Ciències Biològiques, Espanha
2019/07/24	Adenosinergic control of fear extinction: the role of adenosine A2A receptors in the basolateral amygdala Arguente principal	Vanessa Lourenço (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/23	Characterization of maternal behaviors in mice. Pheromonal control and nonapeptidergic substrate Arguente	Ana Martin Sanchez (Doutoramento) Universitat de València, Espanha
2013/12/20	Unraveling the biological role of neudesin, a novel neurotrophic factor Arguente	Ashley da Cruz Novais (Doutoramento) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2024 - Atual	iScience
2024 - Atual	J Medicinal Chemistry
2023 - Atual	Frontiers in Molecular Neuroscience
2023 - Atual	Neurobiology of Stress
2023 - Atual	Scientific Reports
2021 - Atual	Frontiers in Molecular Neuroscience
2020 - Atual	Neurochemical Research
2020 - Atual	Psychoneuroendocrinology
2016 - Atual	Psychiatry Research (0165-1781)	Elsevier
2016 - Atual	Clinical Epigenetics (1868-7083)	Springer-Verlag
2016 - Atual	Human Genetics (1432-1203)	Springer-Verlag
2015 - Atual	PLoS ONE (1932-6203)	Public Library of Science
2013 - Atual	Journal of Neuroscience Research (1097-4547)	Wiley (John Wiley & Sons)
2012 - Atual	BMC Neuroscience (1471-2202)	Springer (Biomed Central Ltd.)
2009 - Atual	Neuroscience (0306-4522)	Elsevier

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2022/01/01 - Atual	Member of the scientific committee of FinRett, a Spanish and Catalan Rett syndrome research fund. Membro	FinRett, Espanha	FinRett
2022/01/01 - Atual	External reviewer for the Cariplo Telethon Alliance call. Avaliador		Fondazione Telethon Fondazione Cariplo

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2022/09/01 - Atual	Master in Nursing of Mental and Psychiatric Health.	Neuropsychopathology (Mestrado)	Escola Superior de Enfermagem de Coimbra, Portugal
2022 - Atual	Master in Cellular and Molecular Biology	Neuronal Circuits & Behavior (Mestrado)	Universidade de Coimbra, Portugal
2022 - Atual	PhD Program in Biomedicine and Experimental Biology	Pathogenic Mechanisms of Disease (Doutoramento)	Universidade de Coimbra, Portugal
2022 - Atual	PhD Program in Biomedicine and Experimental Biology	Synapse Assembly, Function and Plasticity (Doutoramento)	Universidade de Coimbra, Portugal
2021/03/26 - Atual	Neurobiology and Disease	Cellular and Molecular Biology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/11/06 - Atual	Molecular and Cellular Neurobiology	Cellular and Molecular Biology (Mestrado)	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/10/23 - 2023/11/02	Advanced Techniques in Synapse Biology, Cajal course, Bordeaux Neuroscinces School	Neurotrophin modulation of fear extinction in mice (Doctorat)
2021/09/01 - 2022/01/31	Biochemistry of proteins, nucleic acids and lipids.	Bioquímica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09/01 - 2022/01/31	Introduction to the biochemistry laboratory.	Bioquímica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/10/01 - 2019/04/06	Time to Experiment (Hora de Experimentar)	(Ensino básico 1º ciclo)	Associação Semear Talentos, Portugal
2018/09/17 - 2019/04/06	Engineers & Scientists (Engenheiros e Cientistas)	(Ensino básico 1º ciclo)	Associação Semear Talentos, Portugal
2016/04/18 - 2016/04/18	Seminars in Neuroscience	Basic and Applied Neurosciences (Master Universitario)	Universitat de València, Espanha
2016/04/15 - 2016/04/15	Biomedicine Research Seminars	Medicine (Licence)	Universitat Jaume I Facultat de Ciències de la Salut, Espanha
2014/10 - 2016	Genetic Models	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2014/11 - 2015/10	Lab rotation in Behavioral and Molecular Neurosciences	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2015/04/15 - 2015/04/15	Molecular and Cellular Neurobiology: Genes	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2014/01 - 2015/01	Basic Molecular and Cellular Biology	Master in Integrative Neurosciences (Master Universitario)	Otto-von-Guericke-Universität Magdeburg Fakultät für Naturwissenschaften, Alemanha
2008 - 2012	Cellular and Molecular Basis of Neural Plasticity, Module 2: Integrative Molecular and Cellular Neurobiology	Interuniversitary Master in Neurosciences (Master Universitario)	Universitat de Barcelona Institute of Neurosciences, Espanha
2004 - 2005	Molecules and Cells	Medicine (Licenciatura)	Universidade do Minho Escola de Medicina, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2024/10/22	Investigadores da Universidade de Coimbra identificaram uma molécula capaz de ajudar na extinção das memórias do medo.	90 segundos de Ciência
2024/04	Evitar el Estrés y la Ansiedad. La especialista: Un avance para anular los miedos.	Revista Saber Vivir (Nº 282)
2024/03/29	Proteínas sem Medo	O Futuro do Futuro, segment on Expresso
2024/02/15	Neutralitzar l'ansietat, el rol d'una proteïna ja coneguda que pot ajudar a nous tractaments.	3CAT TVnews
2015/02/04	Of Rett Syndrome. Interview with Mónica Santos.	Investigación Y Ciencia/Blog de ratones y humanos
2008/06/10	Percursos: Mónica Santos, genetics and brain function.	Percursos : Ciência Hoje

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2010 - 2012	Steering committee of the 8th FENS Forum, chair of the Students Committee Membro	8th FENS Forum, Espanha
2008 - 2012	Member of the Young Neuroscientists Committee of the Spanish Neuroscience Society (SENC). Membro	Spanish Neuroscience Society, Espanha

Tutoria

	Tópico	Nome do aluno
2024/03 - 2024/04	Impact of stress immobilization on the amygdala	Leire Rodríguez
2023/09 - 2023/11	Interaction effects of early-life stress and MeCP2 on neurobehavior	Carmen Costas
2022/02 - 2022/04	Inter-individual differences in fear extinction in mice.	Garikoitz Azkona
2019/12 - 2020/02	NT3/TrkC role in the regulation of fear memories.	Elena Martínez

Distinções

Prémio

2013	Bi-annual Research Award Ramón Trias Fargas
2010	CGC Genetics Award Professor Doutor Amândio Tavares
2003	Serono Award in Demyelinating Diseases

Outra distinção

2019	Marie Sklodowska-Curie Action Seal of Excellence European Commission, Bélgica
2018	Marie Sklodowska-Curie Action Seal of Excellence European Commission, Bélgica
2015	Special honor on high merit of work 2nd International Conference on FMR1 premutation., Espanha
2013	Travel Grant from Portuguese Society for Neurosciences
2006	Best oral presentation Duques de Soria Foundation, Espanha