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Tânia Fernandes is Biologist (2015) and Master Molecular and Cell Biology (2017) from the Department of Biology, University of Aveiro (UA). She is a PhD student hired under Portuguese Science Foundation (FCT) individual call for PhD scholarship 2019 (SFRH/BD/148801/2019) at Center for Neuroscience and Cell Biology (CNC)/FMUC and CESAM/UA under the supervision of Dr. Paula Moreira, Dr. Cláudia Pereira and Dr. Rosário Domingues in the field of neuroscience with special focus in lipidomic alterations at ER-mitochondria contacts in Alzheimer disease. During the PhD, she did a 4-month internship in Laboratory of Ca2+ Signalling directed by Dr. Paola Pizzo (Department of Biomedical Sciences, Padua, Italy). In 2014/2015 and 2016/2017 she was research trainee in Laboratory of Cell Cycle and Oncology directed by Dr. Anxo Figueroa Vidal (CiMUS, Santiago de Compostela, Spain). In 2019 she had the opportunity to integrate different project and increase her skills in different areas, through a project fellowship in the area of Alzheimer's disease. Besides her individual research project, she participates in differents projects such as the FCT Exploratory research project (EXPL/MED-FSL/0033/2021) and she was also responsible for laboratory tutoring of degree and master students. Tânia Fernandes is author of two original papers in Biomedicines journal (2021) and in Journal of Neurochemistry (2024), a review in Biology journal (2023), and of a chapter in the book Modulation of Oxidative Stress-Biochemical, Physiological and Pharmacological Aspects (2023). She is also co-author of two papers in Oncotarget journal (2015) and Nature Communications (2024) and two publications in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2020) and in Antioxidants & Redox Signaling (ARS) (2022). Tânia Fernandes also participated in several nationals and internationals scientific meetings and in science outreach activities, namely "Ciência Viva during Summer Holidays", "Brain Awareness Week", and "European Researchers' Night". She was also a member of the GreenKeepers Team at the GreenLabsCIBB Initiative whose mission is to reduce the ecological footprint of scientific activity, involved in the implementation of sustainable daily practices in the laboratory. Presently she is Post-Doc Research Fellow at the Department of Biomedical Sciences under the supervision of Dr. Paola Pizzo.
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Identificação

Identificação pessoal

Nome completo
Tânia Patrícia Dias Fernandes

Nomes de citação

  • Fernandes, Tânia

Identificadores de autor

Ciência ID
571D-6D1A-0745
ORCID iD
0000-0001-7872-2343
Researcher Id
U-5888-2019

Endereços de correio eletrónico

  • taniapfernandes@ua.pt (Profissional)
  • tfernandes@cnc.uc.pt (Profissional)
  • taniapatricia.diasfernandes@unipd.it (Profissional)

Moradas

  • Via Ugo Bassi, 58b, 35121, Padova, Padova, Itália (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2)
Espanhol; Castelhano Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2019/12/03 - 2024
Em curso
 Doctoral Programme in Health Sciences (Doutoramento)
Especialização em Biomedical Sciences
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/11/09 - 2020/11/20
Concluído
 IV Modular Training in Laboratory Animal Science (Diploma de especialização)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Approved
2015/08/31 - 2017/12/11
Concluído
 Molecular and Cellular Biology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
"Role of SOX2 on RasV12-mediated transformation" (TESE/DISSERTAÇÃO)
 17
2011/09/21 - 2015/06/12
Concluído
 Biology (Licenciatura)
Especialização em Biology
Universidade de Aveiro Departamento de Biologia, Portugal
"Role of SOX2 in oncogenic transformation" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/04/15 - Atual Pós-doutorado (Investigação) Università degli Studi di Padova Dipartimento di Scienze Biomediche, Itália
Università degli Studi di Padova, Itália
2023/12/04 - 2024/03/31 Estagiário de Investigação (Investigação) Università degli Studi di Padova Dipartimento di Scienze Biomediche, Itália
Università degli Studi di Padova Dipartimento di Scienze Biomediche, Itália
2020/02/01 - 2024 Investigador (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2019/01/18 - 2020/01/17 Investigador (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
CNC.IBILI, Portugal
2016/09/26 - 2017/09/26 Estagiário de Investigação (Investigação) Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
2014/10/01 - 2015/05/31 Estagiário de Investigação (Investigação) Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
Projetos

Bolsa

Designação Financiadores
2020/02/01 - 2024 Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
SFRH/BD/148801/2019
Bolseiro de Doutoramento
CNC.IBILI, Portugal

Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022 - 2023/06 Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/18 - 2020/01/17 HealthyAging2020
CENTRO-01-0145-FEDER-000012
Bolseiro de Investigação
CNC.IBILI, Portugal
 European Regional Development Fund

Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em jornal
  1. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista?", Público, 2021, https://www.publico.pt/2021/09/15/ciencia/noticia/doencas-neurodegenerativas-quebracabecas-solucao-vista-1975912.
Artigo em revista
  1. Casas, Paloma García; Rossini, Michela; Påvénius, Linnea ; Saeed, Mezida ; Arnst, Nikita ; Sonda, Sonia ; Fernandes, Tânia; et al. "Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters". Nature Communications (2024):
  2. Fernandes, Tânia; Melo, Tânia; Conde, Tiago A.; Bruna B. Neves; Domingues, Pedro; Resende, Rosa; Pereira, Cláudia Fragão; Moreira, Paula Isabel; Domingues, Maria Rosário. "Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease". Journal of Neurochemistry (2024): https://doi.org/10.1111/jnc.16072.
    10.1111/jnc.16072
  3. Fernandes, Tânia; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. Autor correspondente: Pereira, Cláudia F.. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology 12 3 (2023): 414. http://dx.doi.org/10.3390/biology12030414.
    10.3390/biology12030414
  4. Resende, Rosa; Fernandes, Tânia; Pereira, Ana Catarina; Marques, Ana Patrícia; Pereira, Cláudia Fragão. "ER-Mitochondria contacts modulate ROS-mediated signaling and oxidative stress in brain disorders: the key role of Sigma-1 receptor.". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2020.8231.
    Publicado • 10.1089/ars.2020.8231
  5. Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease". Biomedicines 9 8 (2021): 881. http://dx.doi.org/10.3390/biomedicines9080881.
    Acesso aberto • Publicado • 10.3390/biomedicines9080881
  6. Fernandes, Tânia; Resende, Rosa; Domingues, Maria R.; Paula I. Moreira (9C16-2F47-6D91); Pereira, Cláudia Fragão. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". European Journal of Clinical Investigation 51 S1 (2021): http://dx.doi.org/10.1111/eci.13567.
    Publicado
  7. Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752. http://dx.doi.org/10.1016/j.bbadis.2020.165752.
    Acesso aberto • Publicado • 10.1016/j.bbadis.2020.165752
  8. Vilas, Jéssica M.; Ferreirós, Alba; Carneiro, Carmen; Morey, Lluis; Da Silva-Álvarez, Sabela; Fernandes, Tânia; Abad, María; et al. "Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins". Oncotarget 6 5 (2015): http://dx.doi.org/10.18632/oncotarget.2996.
    Acesso aberto • Publicado • 10.18632/oncotarget.2996
Capítulo de livro
  1. Fernandes, Tânia; Domingues, M. Rosário; Pereira, Cláudia F.; Moreira, Paula I.. "Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer disease". In Modulation of Oxidative Stress, editado por Luciano Saso; Alessandro Giuffré; Giuseppe Valacchi; Mauro Maccarrone, 81-96. Elsevier, 2023.
    10.1016/b978-0-443-19247-0.00012-6
Tese / Dissertação
  1. Fernandes, Tânia. "Role of SOX2 on RasV12-mediated transformation". Mestrado, Universidade de Aveiro Departamento de Biologia, 2017. http://hdl.handle.net/10773/22010.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/05 Inhibition of diglyceride acyltransferase (DGAT1) improves the ER-mitochondria interaction in an in vitro Alzheimer's disease model 58th Annual Scientific Meeting of the European Society of Clinical (ESCI)
European Society of Clinical (ESCI) (Barcelona, Espanha)
2023/10/26 Altered lipid metabolism in Alzheimer's disease Master in Biomedical Research (MIB) - Research Methods and Techniques (RMT)
Faculty of Medicine of University of Coimbra (Coimbra, Portugal)
2023/09/08 Impaired ER-mitochondria contacts affect lipid droplets degradation in an in vitro Alzheimer's disease model 9th Workshop of the European Calcium Society - "Mitochondrial Ca2+ Signaling in Health and Disease”
European Calcium Society (Padua, Itália)
2023/04/12 Disrupted ER-mitochondria communication correlate with changes in the lipid profile in an Alzheimer's disease in vitro model 11th Workshop in Lipidomics -Lipidomics in Health and Disease
Mass Spectometry Centre, University of Aveiro (Aveiro, Portugal)
2023/02/03 Alterations in the ER-Mitochondria Contacts Affect Lipid Metabolism in an Alzheimer's Disease in vitro Model 53rd SPF Meeting
Portuguese Society of Farmacology (Coimbra, Portugal)
2023/01/13 Lipid disturbances in Alzheimer's disease pathogenesis 3rd Retreat of CIBB's Metabolism, Aging and Disease Area
CIBB - Center for Innovative Biomedicine and Biotechonology (Coimbra, Portugal)
2021/11/18 Structural and functional alterations in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease 2nd Retreat of CIBB's Metabolism, Aging and Disease Area
CIBB - Center for Innovative Biomedicine and Biotechonology (Coimbra, Portugal)
2021/06/11 Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model 55th Annual Scientific Meeting
European Society for Clinical Investigation (Online Event)
2020/09/26 Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models 34ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD) (Webinar, Portugal)
2020/02/07 Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer's Disease L SPF Meeting
Portuguese Society of Farmacology (Coimbra, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/11/30 - 2023/12/02 Poster - Impaired ER-mitochondria contacts affect lipid droplets metabolism in an in vitro Alzheimer's disease model
Congresso
 Mitochondria in Aging, Cancer and Cell Death (MAC)
Universidade de Coimbra, Portugal
2023/09/22 - 2023/09/22 Poster - GreenLabsCIBB: One path for sustainable research
Simpósio
 Green Labs Portugal Symposium: Promoting sustainability in Research
Universidade de Coimbra, Portugal
2023/09/22 - 2023/09/22 Poster - "Collection Points”: Reuse and Recycling
Simpósio
 Green Labs Portugal Symposium: Promoting sustainability in Research
Universidade de Coimbra, Portugal
2023/06/06 - 2023/06/06 Poster - GreenLabsCiBB: One path for sustainable research EU-LIFE 10th Anniversary Conference
2022/09/30 - 2022/09/30 To be or not to be GreenLab - What type of plastic am I?
Outro
 NEI - European Researchers' Night
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
2019/12/17 - 2019/12/18 Poster - Analysis of Mitochondria-Associated Membranes (MAMs) in an Alzheimer's disease in vitro model CIBB Meeting 2019
CNC.IBILI, Portugal
2019/09/02 - 2019/09/06 As part of the summer internship program “Ciência Viva no Laboratório” we welcome students up to the 12th grade in the laboratory. In this internship, students had the opportunity to carry out experiments to investigate how the cells of bipolar patients and healthy people respond to stress.
Outro
 Summer internships "Ciência Viva no laboratório" - Ups and Downs of Bipolar Disorder
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/01 - 2019/03/29 During the Brain Awareness Week, I was involved in the science communication activity "Neuroscientists Go to Schools", where I went to a school in the region for lectures and activities dedicated to the topic of neurosciences.
Outro
 Brain Awareness Week
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/05/25 - 2016/05/25 Workshop in Immunology with the objective of demonstrating the use of mass spectrometry in immunological studies
Oficina (workshop)
 4º Workshop in Immunology
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2014/04/23 - 2014/04/23 Workshop with the objective of combining mass spectrometry with the study of carbohydrates
Oficina (workshop)
 3º Workshop Mass spectrometry and Carbohydrates
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2014/03/19 - 2014/03/19 Workshop organized by the Nucleus of Chemistry Students of the University of Aveiro with the aim of deepening knowledge in Immunology
Oficina (workshop)
 Workshop in Immunology
Universidade de Aveiro Departamento de Química, Portugal
2013/12/13 - 2013/12/13 Cycle of lectures in the scope of male reproduction in order to demonstrate the research carried out at the University of Aveiro in this field of investigation
Conferência
 Male Reproduction
Universidade de Aveiro Instituto de Biomedicina, Portugal
2013/06/12 - 2013/06/14 Conference of the Portuguese Chemical Society
Encontro
 XXIII Portuguese Society of Chemical Meeting
Universidade de Aveiro Departamento de Química, Portugal
2013/04/20 - 2013/04/20 Lectures in Oncology
Encontro
 IV Jornadas de Ciência e Medicina - Oncologia
Universidade do Minho Escola de Medicina, Portugal
2013/04/12 - 2013/04/13 Lectures in Immunomedicine at the Harvard Medical School Annual Meeting
Simpósio
 V Simpósio Anual da Harvard Medical School - Portugal Program
Universidade de Coimbra, Portugal
2013/04/10 - 2013/04/10 Workshop in Lipidomics with the aim of demonstrating the use of mass spectrometry in lipidomics studies
Oficina (workshop)
 2º Workshop in Lipidomics
Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2013/03/22 - 2013/03/24 Conferences and workshops in the field of Biochemistry
Encontro
 VI Encontro Nacional de Estudantes de Bioquímica
Universidade de Aveiro Departamento de Química, Portugal
2013/03/14 - 2013/03/14 Conferences in which the following contents were addressed: immunology, bioinformatics, rare diseases and orphan drugs, translational medicine, cell biology and stem cells, oncology and pharmacogenetics, neurosciences
Encontro
 IV Jornadas Nacionais de Ciências Biomédicas
Universidade de Aveiro Departamento de Ciências Médicas, Portugal

Membro de associação

Nome da associação Tipo de participação
2022/07 - 2024/04 GreenLabs Portugal We are a network of Portuguese grassroot “green teams” made up of scientists and other employees of research institutes that advocate for sustainable research practices to reduce the environmental impact of research in Portugal. Member of the GreenKeepers Team at the GreenLabsCIBB Initiative

Tutoria

Tópico Nome do aluno
2023/10/02 - 2023/10/06 Master in Biomedical Research (MIB) - Lab Rotations 4 students
2023/05/22 - 2023/06/09 Master in Biomedical Research (MIB) - Integrative Multidisciplinar Research Project 'Cellular stress response in mental diseases' Ânia Isabel Correia Rodrigues
2023/01/30 - 2023/02/03 Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - Course Neuroscience - Pathogenic Mechanisms in Neuropsychiatric and Neurodegenerative Disorders Ana Sofia Figueira e Sara Martins
2022/10/03 - 2022/10/04 Master in Biomedical Research (MIB) - Lab Rotations 3 students
2021/05 - 2021/07 Degree Project in Laboratory Biomedical Sciences Mariana Freitas
2020/02 - 2020/10 Master's Thesis in Genetic and Molecular Biotechnology Daniele Ciampi
2019 - 2019 Internship - Ciência Viva no Laboratório Daniela Roque e Sofia Batista
Distinções

Prémio

2024 Travel Grant
European Society for Clinical Investigation, Países Baixos
2023 Best Poster Presentation
Mitochondria in Aging, Cancer and Cell Death (MAC), Portugal
2015 Merit Scholarship for Exceptional Academic Achievement 2014-2015
Universidade de Aveiro, Portugal