Beatriz Fernanda da Silva Guedes (5D1B-56D5-983F)

Curriculum Vitae

Beatriz Fernanda da Silva Guedes

Beatriz Guedes holds a Bachelor's degree in Genetics and Biotechnology from the University of Trás-os-Montes and Alto Douro (UTAD) and a Master's degree in Clinical Laboratory Genetics from the Faculty of Medicine of the University of Coimbra (FMUC). Her master’s thesis was focused on exploring the role of a candidate microRNA in mitochondrial dysfunction and inflammatory responses in Parkinson’s Disease, under the supervision of Dr. Ana Raquel Esteves, at the Gut-Brain Axis Group from the Center for Neuroscience and Cell Biology (CNC-UC). Along with her master’s thesis, she also worked on another projects, leading to the publication, as co-author, of one book chapter and two original papers, currently published in Redox Biology and International Journal of Molecular Sciences. Furthermore, as a result of the work that she developed for her master’s thesis, she is first author of one review article published in Biomedicines and one original publication that is under preparation. Moreover, she was first author in a conference poster and in an oral communication in two international meetings, specifically "AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders" (Gothenburg, Sweden) and "57th Annual Scientific Meeting of the European Society for Clinical Investigation 2023" (Prague, Czech Republic). Additionally, she was first author of two poster communications in national meetings: "MAC- Mitochondria in Aging, Cancer, and Cell Death 2023" and “18th edition of the PDBEB symposium: (Not) Knowing What Comes Next: Tools for the Research of Tomorrow”. Moreover, she presented her work, as a speaker, at the 11th edition on signal transduction – SINAL 2024. Beatriz has been awarded a master’s research grant for the development of R&D activities within the project "Proof of concept for blood biomarkers of Alzheimer's Disease" at iBiMED (University of Aveiro) and worked as a researcher at the Advanced Therapies Group (CNC - UC-Biotech), on the "Reset Bone Ageing" project. Most recently, she was awarded a FCT PhD Fellowship.

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Identificação

Identificação pessoal

Nome completo: Beatriz Fernanda da Silva Guedes

Nomes de citação

Guedes, B
Guedes, BFS

Identificadores de autor

Ciência ID: 5D1B-56D5-983F
ORCID iD: 0000-0002-8171-9062

Endereços de correio eletrónico

beatrizfsguedes@gmail.com (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Espanhol; Castelhano	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2020 - 2023 Concluído	Clinical Laboratory Genetics (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal "The Role of a Candidate microRNA in Mitochondrial Dysfunction and Inflammatory Responses in vitro: Relevance to Parkinson’s Disease" (TESE/DISSERTAÇÃO)	17
2015 - 2020 Concluído	Genetics and Biotechnology (Licenciatura) Universidade de Trás-os-Montes e Alto Douro, Portugal "A study in Drosophila melanogaster about the genotoxic impact of radiation emitted by cell phones" (TESE/DISSERTAÇÃO)	14

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/12/01 - 2024/05/31	Investigador (Investigação)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

2023/04 - 2023/07	Investigador (Investigação)	Universidade de Aveiro Instituto de Biomedicina, Portugal

2021/09 - 2022/12	Estagiário de Investigação (Investigação)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023/04 - 2023/07	Proof of concept for blood biomarkers of Alzheimer's Disease CENTRO-01-0145-FEDER-181255 Investigador Universidade de Aveiro Instituto de Biomedicina, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Em curso

Outro

	Designação	Financiadores
2023/12/01 - Atual	Reset Bone Ageing: Coating for orthopedic prostheses with the ability to increase bone tissue regeneration POCI-01-0247-FEDER-069790 Investigador Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	European Regional Development Fund Em curso
2021/09 - 2022/12	Microbiome-miRNAs axis in Parkinson's disease: involvement of mitochondria mediated inflammatory response EXPL/MED-NEU/1515/2021 Master Student Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Fundação para a Ciência e a Tecnologia Em curso

Produções

Publicações

Artigo em revista	Vicente-Zurdo, D; Brunetti, L; Piemontese, L; Guedes, B; Cardoso, SM; Chavarria, D; Borges, F; et al. "Rivastigmine-Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences (2023): Acesso aberto • Publicado • 10.3390/ijms24098312 Guedes, BFS; Cardoso, SM; Esteves, AR. "The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson's Disease". Biomedicines (2023): Acesso aberto • Publicado • 10.3390/biomedicines11051349 Esteves, AR; Silva, DF; Banha, D; Candeias, E; Guedes, B; Cardoso, SM. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology (2023): Acesso aberto • Publicado • doi.org/10.1016/j.redox.2023.102714
Capítulo de livro	Candeias, E.; Nunes-Costa, D.; Magalhães, JD.; Esteves, AR.; Pereira-Santos, AR.; Marques, I.; Guedes, B.; Empadinhas, N.; Cardoso, SM.. "Neurotoxicity induced by ß-N-methylamino-L-alanine". In Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier Inc. Publisher., 2022. Publicado
Poster em conferência	Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "Unveiling miR-486-5p role in Parkinson’s Disease: mitochondrial dysfunction and inflammation in vitro". Trabalho apresentado em 18th edition of the PDBEB symposium: (Not) Knowing What Comes Next: Tools for the Research of Tomorrow, 2024. Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "A gut miRNA targets cardiolipin synthase and affects mitochondrial function: relevance for Parkinson's disease". Trabalho apresentado em MAC- Mitochondria in Aging, Cancer and Cell Death, 2023. Beatriz Guedes; Sónia Duarte; Sandra Morais Cardoso; Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Trabalho apresentado em AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (Gothenburg, Sweden), 2023.
Relatório	Guedes, B. 2019. Bachelor's Internship: A study in Drosophila melanogaster about the genotoxic impact of radiation emitted by cell phones.
Tese / Dissertação	"The Role of a Candidate microRNA in Mitochondrial Dysfunction and Inflammatory Responses in vitro: Relevance to Parkinson's Disease". Mestrado, Universidade de Coimbra Faculdade de Medicina, 2023.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/05/24	miR-486-5p impact on mitochondrial dysfunction and inflammation in vitro: relevance to Parkinson’s Disease (First Author and Presenting Author)	11th Edition on Signal Transduction – SINAL 2024 (Coimbra, Portugal)
2024/03/20	Does Parkinson's Disease Start in the Gut? The role of miR-486-5p in mitochondrial dysfunction and inflammatory responses: relevance to Parkinson's Disease (First Author and Presenting Author)	Brain Gain: 2024 Edition (Portugal)
2023/07/06	Uncovering a candidate gut miRNA role in mitochondrial dysfunction and inflammation: impact on Parkinson's disease. (First Author; Presenting Author - Ana Raquel Esteves)	57th Annual Scientific Meeting of the European Society for Clinical Investigation 2023 (Prague, República Checa)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/11/29 - 2022/11/29	Attended the Symposium: Genetic Tests in Context: people, families, society - 25 years of genetic tests at IBMC. Simpósio	Genetic Tests in Context: people, families, society - 25 years of genetic tests at IBMC Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2022/05/02 - 2022/05/06	Attended the Proteomics Approaches in Life Sciences Course.	Proteomics Approaches in Life Sciences Course Biocant Associação de Transferência de Tecnologia, Portugal
2021/11/30 - 2021/11/30	Attended the V Symposium of the Portuguese Glial Network. Simpósio	V Symposium of the Portuguese Glial Network Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2021/11/26 - 2021/11/26	Attended the 9th Neurogenetics Meeting - The genes of my eyes: Neurogenetic diseases with ophthalmic manifestations. Encontro	The genes of my eyes: Neurogenetic diseases with ophthalmic manifestations Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/10/11 - 2021/10/13	Attended the 3rd NMS Symposium about Chronic Diseases and Translational Science. Simpósio	3rd NMS Symposium: Chronic Diseases and Translational Science Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/07/07 - 2021/07/07	Attended the 2nd GenomePT Symposium. Simpósio	2nd GenomePT Symposium Biocant Associação de Transferência de Tecnologia, Portugal Universidade de Aveiro Instituto de Biomedicina, Portugal