João Pedro Ferreira da Costa Novo (6A14-AF6E-0374)

Curriculum Vitae

João Pedro Ferreira da Costa Novo

João Pedro Ferreira da Costa Novo. Completed the Mestrado in Mestrado em Investigação Biomédica in 2019/09/27 by Universidade de Coimbra Faculdade de Medicina and Licenciatura in Licenciatura em Ciências Biomédicas in 2017/06/23 by Universidade de Aveiro Departamento de Ciências Médicas. Attends the Doutoramento in Biologia Experimental e Biomedicina by Universidade de Coimbra Instituto de Investigação Interdisciplinar since 2021/12/01. Published 4 articles in journals. Has 1 section(s) of books. Organized 3 event(s). Participated in 9 event(s). Has received 3 awards and/or honors. Participates and/or participated as Other in 1 project(s), PhD Student Fellow in 1 project(s), Research Fellow in 3 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences, Medical and Health Sciences, Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Metilfenidato; Microglia; Células Endoteliais; Neuroinflamação; Stress Oxidativo; Methylphenidate; Endothelial cells; Neuroinflammation; Oxidative Stress; Methylmercury; Mercury cycle; Neurotoxicity; Neurons; Oligodendrocytes; Astrocytes; Apoptosis; Necrosis; Cognition; Synaptic function; Neurogenesis; Aging; Ageing; Senescence; Blood-brain barrier; Nanoparticles; Neurosciences; Vision Sciences; Senolytics; Brain; Science; Science communication; Bone regeneration; Innovation; Health; Entrepreneurship; Career; Mental Health; Science Funding; Clinical Trials; Nerve Regeneration; Spinal Cord; Hippocampus; Inflammatory mediators; neurodegeneration; Brain endothelial cells; .

Ler resumo completo ↓

Identificação

Identificação pessoal

Nome completo: João Pedro Ferreira da Costa Novo

Nomes de citação

Novo, João Pedro

Identificadores de autor

Ciência ID: 6A14-AF6E-0374
ORCID iD: 0000-0001-8015-2685

Endereços de correio eletrónico

jpfcnovo@gmail.com (Profissional)
jnovo@cnc.uc.pt (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Médicas e da Saúde
Ciências Naturais - Ciências Biológicas - Biologia Celular
Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2021/12/01 - 2025/11/30 Em curso	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/05/16 - 2022/05/26 Concluído	Connecting Researchers with the Society and Industry (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/11/09 - 2020/11/20 Concluído	IV Modular Training in Laboratory Animal Course - Function A (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	14,85
2017/09 - 2019/09/27 Concluído	Mestrado em Investigação Biomédica (Mestrado) Especialização em Neurobiologia Universidade de Coimbra Faculdade de Medicina, Portugal "Effect of methylphenidate on microglia: tracking direct and brain endothelial cells-mediated changes" (TESE/DISSERTAÇÃO)	18,3
2014/09 - 2017/06/23 Concluído	Licenciatura em Ciências Biomédicas (Licenciatura) Especialização em Molecular Biomedicine Universidade de Aveiro Departamento de Ciências Médicas, Portugal	16,2

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2021/06/01 - 2021/11/30	Investigador (Investigação)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/15 - 2021/04/14	Investigador (Investigação)	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal
2020/01/01 - 2020/12/31	Investigador (Investigação)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal

Projetos

Projeto

	Designação	Financiadores
2021/06/01 - Atual	A therapeutic strategy to fight blood-brain-barrier (BBB) ageing PTDC/BTM-SAL/5174/2020 Bolseiro de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Centro de Inovação em Biomedicina e Biotecnologia, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - Atual	Reset Ageing 952266 Bolseiro de Doutoramento Universidade de Coimbra, Portugal Newcastle University, Reino Unido Universiteit Maastricht, Países Baixos Leibniz Institut für Altersforschung - Fritz-Lipmann Institut eV, Alemanha	European Comission Em curso
2021/01/15 - 2021/04/14	Enhancing Research in Ageing (ERA@UC) Grant agreement ID: 669088 Bolseiro de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra Concluído
2020/01/01 - 2020/12/31	HealthyAging 2020 Centro 2020 000012 Healthy Aging 2020 Bolseiro de Investigação Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2020/01/01 - 2020/12/31	MercuMemory: Methylmercury neurotoxicity in adult brain neurogenic niches: chronic neurogeneration and cognitive decline. POCI-01-0145-FEDER-031699 Investigador Faculdade de Medicina da Universidade de Coimbra, Portugal	Concluído
2018/05 - 2019/07	BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias CENTRO-01-0145-FEDER-000008 Aluno de mestrado Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Novo, João Pedro; Gee, Lucy; Caetano, Carolina A.; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S.; et al. "Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence". Aging Cell (2024): http://dx.doi.org/10.1111/acel.14270. Acesso aberto • 10.1111/acel.14270 Novo, João Pedro; Muga, Mariana; Lourenço, Teresa; Sanches, Eliane S; Leitão, Ricardo A.; Silva, Ana Paula. "Dichotomous effect of methylphenidate on microglia and astrocytes: Insights from in vitro and animal studies". Toxicology Letters 389 (2023): http://dx.doi.org/10.1016/j.toxlet.2023.10.008. Acesso aberto • 10.1016/j.toxlet.2023.10.008 Martins, B.; Novo, João Pedro; Fonseca, É.; Raposo, R.; Sardão, V. A.; Pereira, F.; Oriá, R. B.; Fontes-Ribeiro, C.; Malva, J.. "Necrotic-like BV-2 microglial cell death due to methylmercury exposure". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.1003663. Publicado • 10.3389/fphar.2022.1003663 Novo, João Pedro; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B.; Malva, João O.; Fontes-Ribeiro, Carlos. Autor correspondente: Malva, João O.. "Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neuroinflammation". International Journal of Molecular Sciences 22 6 (2021): 3101. http://dx.doi.org/10.3390/ijms22063101. Acesso aberto • Publicado • 10.3390/ijms22063101
Capítulo de livro	João O. Malva; Beatriz Martins; Ricardo Moreira; Novo, João Pedro; Frederico C. Pereira; Ramon Raposo; Reinaldo oriá; Fontes Ribeiro CA. "Neuroinflammation in the elderly". In Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, editado por Colin Martin; Victor Preedy; Rajkumar Rajendram, 139-148. Londres, Reino Unido: Academic Press - Elsevier, 2021. Publicado
Poster em conferência	Novo, João Pedro; Caetano, Carolina; Susana Carvalho Rosa; Thomas von Zglinicki; Ferreira, Lino. "Development of an in vitro human blood-brain barrier model with ageing properties". Trabalho apresentado em 3rd RESETageing Conference, 2023. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Trabalho apresentado em Annual Meeting of the European Tissue Repair Society (ETRS) and the Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), 2023. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Trabalho apresentado em Annual Meeting of the German Association for Aging Research (DGfA), 2023. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Trabalho apresentado em 2nd RESETageing Conference - Biology of Ageing: Senescence and Cell Stress, 2022. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Trabalho apresentado em 1st MIA Portugal Spring School on Aging, 2022. Novo, João Pedro; Caetano, Carolina; L. Gee; Moreira, Irina S; Diana Jurk; Rosa, Susana; Ferreira, Lino. "The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022. João P. Novo; Carolina Caetano; Rosa, Susana; Ferreira, Lino. "An in vitro human senescent blood-brain barrier model". Trabalho apresentado em BEB Day 2022 - The overview effect, 2022. Élisa Fonseca; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Frederico C. Pereira; Reinaldo B. Oriá; Carlos Fontes-Ribeiro; João O. Malva. "Neurotoxicity and molecular effects of acute Methylmercury exposure in Microglial Cells". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Élisa Fonseca; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Frederico C. Pereira; Reinaldo B. Oriá; Fontes Ribeiro C; João O. Malva. "Acute Methylmercury exposure induces Neurotoxicity and Microglial Cell Death". Trabalho apresentado em V Symposium Portuguese Glial Network 2021, 2021. Novo, João Pedro; Beatriz Martins; Ramon Raposo; Frederico C. Pereira; Reinaldo Oriá; João O. Malva; Fontes Ribeiro CA. "The Effect Of Methylmercury On Microglia Inflammatory Responses". Trabalho apresentado em SPF Meeting 2021, 2021. Beatriz Martins; Novo, João Pedro; Ricardo Moreira; Ramon Raposo; Frederico C. Pereira; Reinaldo Oriá; João O. Malva; Fontes Ribeiro CA. "The Impact Of Methylmercury On Microglia-Derived Neuroinflammation And Neurogenesis". Trabalho apresentado em I International CAPES Print Symposium in Neurosciences and III Simpósio Luso-Brasileiro de Neurociências, 2020. Novo, João Pedro; Santos, Liliana; Leitão, Ricardo Alexandre; Fontes Ribeiro CA; Rosa Cristina Simões Fernandes; Ana Paula Pereira da Silva Martins. "Effect of methylphenidate on microglia: an in vitro study". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences,, 2019. Beatriz Martins; Novo, João Pedro; João O. Malva; Fontes Ribeiro CA; Ana Paula Pereira da Silva Martins; Frederico Pereira; Reinaldo oriá. "Mercumemory: the effect of methylmercury exposure in microglia-mediated neuroinflammation". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 2019. Beatriz Martins; Novo, João Pedro; Ana Paula Pereira da Silva Martins; Frederico Pereira; Reinaldo oriá; Fontes Ribeiro CA; João O. Malva. "Unraveling the effect of methylmercury exposure in neuroinflammation and neurogenesis". Trabalho apresentado em Sociedade Portuguesa de Neurociências Meeting, 2019.
Resumo em conferência	Fonseca, Élisa; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Pereira, Frederico; Oriá, Reinaldo B.; Fontes Ribeiro C; João O. Malva. "Necrotic-like BV-2 Microglial cell death induced by acute exposure to Methylmercury". Trabalho apresentado em FENS Forum 2022, Paris, 2022. Submetido Fonseca, Élisa; Novo, João Pedro; Corte Real Martins, Beatriz; Raposo, Ramon; Sardão, Vilma; Oliveira, Paulo; Pereira, Frederico; et al. "BV-2 Microglial cell death induced by acute exposure to Methylmercury". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2022), Bari, 2022. Submetido
Tese / Dissertação	Novo, João Pedro Ferreira da Costa. "Effect of methylphenidate on microglia: tracking direct and brain endothelial cells-mediated changes". Mestrado, Universidade de Coimbra Faculdade de Medicina, 2019. http://hdl.handle.net/10316/89656.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/05/29	Brain endothelial senescence mediates blood-brain barrier dysfunction upon ageing: development of an in vitro BBB model	MIA-Portugal Ageing Spring School 2024 MIA-Portugal (Coimbra, Portugal)
2024/03/18	The transition from a young to aged BBB is mediated by a senescence brain endothelial cell program	Young ICSA Symposium Young International Cell Senescence Association (ICSA) (Oxford, Reino Unido)
2022/12/06	The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program	Ageing without Borders Ageing without Borders - Algarve Biomedical Center Research Institute (Faro, Portugal)
2022/09/17	The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program	2nd RESETageing Conference: Biology of Ageing: Senescence and Cell Stress ResetAgeing - Newcastle University (Newcastle, Reino Unido)
2022/06/03	Senescent brain endothelial cell program partially mediates the transition from young to aged Blood-Brain Barrier	I International Meeting on the Brain Vasculature NOVA Medical School (Portugal)
2022/04/06	The transition from a young to aged BBB is mediated in part by a senescence brain endothelial cell program	1st MIA Portugal Spring School on Aging Multidisciplinary Institute of Ageing (MIA) Portugal (Coimbra, Portugal)
2020/07/08	Mercury toxicity in neuroinflammation and neurogenesis	CIBB Neuroscience and Disease 2020 Online Retreat CIBB - Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2019/05/10	Neurovascular alterations induced by methylphenidate: ADHD versus control	1st CIBB Neuroscience and Disease Retreat CIBB - Center for Innovative Biomedicine and Biotechnology (Miranda do Corvo, Portugal)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2022/09/01 - 2023/02/08	The 17th edition of the PDBEB symposium organized by the Doctoral Programme in Experimental Biology and Biomedicine students, from the Institute of Interdisciplinary Research, University of Coimbra, took place on the 7th and 8th of February 2023. Under the theme "Science Challenges: This Fight of Ours!", this edition gathered a multidisciplinary panel to address current issues that affect the scientific community with a special focus on science financing, clinical trials, mental health, and science communication. https://www.cnc.uc.pt/en/pdbeb/beb (2023/02/07 - 2023/02/08) Simpósio (Membro da Comissão Organizadora)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/07/09 - 2022/07/09	PicNic with Health (PicNiC com Saúde) was promoted by the Institute of Clinical and Biomedical Research of Coimbra and the Faculty of Medicine of the University of Coimbra. With an informal character and designed for all ages, PicNic with Health aimsed to lead people to adopt healthier habits. (2022/07/09 - 2022/07/09) Exposição (Outra)	Universidade de Coimbra Faculdade de Medicina, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2022/05/20 - 2022/05/20	Brain Fair organized by CNC UC, took place in the Botanical Garden of the University of Coimbra. This event was an initiative within the scope of the Brain Awareness Week and was focused on science communication and public engagement. (2022/05/20 - 2022/05/20) Exposição (Membro da Comissão Organizadora)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/05/26 - Atual	PhD project presentation for high school students on the scope of the Advanced Course "Connecting Researchers with the Society and Industry" Outro	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/09/29 - 2023/09/29	The European Researchers' Night (NEI) was a Science Communication event that took place in downtown Coimbra, with the aim of promoting awareness and the population's involvement in science, bringing researchers and civil society closer together. Researchers showed their Science, in the most varied scientific areas, approaching the citizens of Coimbra and the whole community, promoting scientific literacy. NEI took place simultaneously in several cities in Europe. Exposição	2023 European Researcher's Night Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/11/07 - 2022/11/11	i-Days promote health innovation among university students through dozens of one-day and two-day programmes held in academic institutions around Europe. Students from all academic areas receive an introduction to practical health innovation tools and compete in teams to tackle real-life health challenges posed by EIT Health, local organisations, private corporations or start-ups. Oficina (workshop)	Cantanhede Innovation Days 2022 European Institute of Innovation & Technology (EIT) Health, Hungria
2022/10/11 - 2022/10/11	The second edition of FIC.A - International Science Festival took place between the 10th and 16th of October, in , Hub-ACT (Art, Science & Technology), a future incubation center for creative industries, in Porto Salvo, Oeiras, Portugal. During 7 days, the Festival aimed to inspire and capture the attention of children and adults, create new audiences for science and use the arts to communicate exciting science and technology. The mission was to inspire visitors of all ages with the amazing science, engineering and technology we find all around us. Exposição	FICA - Festival Internacional de Ciência Câmara Municipal de Oeiras, Portugal
2022/09/30 - 2022/09/30	The European Researchers' Night (NEI) was a Science Communication event that took place in downtown Coimbra. Researchers showed their Science, in the most varied scientific areas, approaching the citizens of Coimbra and the whole community, promoting scientific literacy. NEI took place simultaneously in several cities in Europe. Exposição	2022 European Researcher's Night Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/09/16 - 2022/09/17	The 2nd RESETageing Conference - Biology of Ageing: Sconference is organized in Newcastle for 2 days. The event is supported by the European project RESETageing that has been funded by the H2020 Widespread Twinning program. Ageing is a triumph of the contemporary society but also represents a great challenge for the coming generations. The conference chaired by Satomi Miwa, Thomas von Zglinicki, Viktor Korolchuk and Luís Estronca aims to show us recent progresses in the ageing biology covering aspects as cellular senescence and cellular stress. Conferência	2nd RESETageing Conference - Biology of Ageing: Senescence and Cell Stress Newcastle University, Reino Unido
2022/09/12 - 2022/09/15	Training School - Single cell techniques in senescence and ageing. Delivered in collaboration with the Flow Cytometry Core Facility of Newcastle University Oficina (workshop)	Training School - Single cell techniques in senescence and ageing Newcastle University, Reino Unido
2021/09/24 - 2021/09/24	The European Researchers' Night is a Europe-wide public event, that displays the diversity and impact of science on citizens' daily lives in inspiring ways. The yearly theme in Portugal was aligned with the European Ecological Pact, which proposes that the neutral impact on the climate by 2050, through the promotion of initiatives that protect the environment and boost the green economy. The activities included the promotion of beneficial habits for the environment and the communication the communication of research carried out by the laboratory. Exposição	2021 European Researchers' Night Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018	The European Researchers' Night is a Europe-wide public event, that displays the diversity and impact of science on citizens' daily lives in inspiring ways. Research centers at the University of Coimbra promote activities to disseminate science to different audiences. Exposição	2018 European Researchers' Night Universidade de Coimbra Faculdade de Medicina, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/10/18 - Atual	Food Science and Nutrition (2048-7177)	Wiley Periodicals, LLC.

Membro de associação

	Nome da associação	Tipo de participação
2022/07 - 2022/12	Cartas com Ciência - Letters with Science	Scientist

Distinções

Prémio

2022	Best short communication - I International Meeting on the Brain Vasculature Nova Medical School, Portugal Sociedade Portuguesa de Neurociências, Portugal Concessus, Portugal
2021	2021 FCT PhD Studentship Fundação para a Ciência e a Tecnologia, Portugal

Título

2022	CIBB PhD Students Representative