Vitor Manuel dos Santos Francisco (7A1A-3400-E0A5)

Curriculum Vitae

Vitor Manuel dos Santos Francisco

Vitor Francisco graduated in Chemistry from University of Coimbra in 2008 and completed a PhD degree in Physical Chemistry from the University of Santiago de Compostela (Spain) in 2014 where he contributed to the field of drug delivery using supramolecular chemistry. Since obtaining his PhD degree, he joined the group of Lino Ferreira, ERC and ERA Chair grantee, at Center for Innovative Biomedicine and Biotechnology with a post-doctoral fellowship and then as contracted researcher, where he is currently focusing on controlled delivery of drugs mainly for ageing-related diseases. V. Francisco has published 26 articles in international peer-reviewed journals ranked in the highest quartile (Q1), has 1 patent registered, 1 provisional patent application and 1 under preparation. He is Guest Associate Editor at Frontiers in Chemistry, Reviewing Editor at Experimental Results (Cambridge Uni. Press) and has been reviewer in various reputed journals such as Small, Chem Eur J, Nanoscale, among others. Over the years, V. Francisco has been integrated in the team of several research projects funded by European Commission, Gobierno de España (Agencia Estatal de Investigacion) and Portuguese Science Foundation (FCT). Moreover, V. Francisco has also participated in several national and international conferences often contributing with oral presentations (18 in total), including two invited lectures at AEICBAS Biomedical Congress and EMBE2022. In the last 5 years he secured, as Principal Investigator, 340k Eur (240 k in 2018, 50k in 2022 and 50k in 2024) from the national funding agency (FCT). In the project started in 2018 and finished in 2022, the aim was to develop a platform for the delivery of RNA-based therapies. The results of this project were published in medium/high impact journals such as Adv. Science (IF = 14.3), Angew Chemie (IF = 15.336) or Nanoscale Horizons (IF = 11.684) and one patent was granted. Since 2021, he is also Co-PI of another FCT project (50k Eur) for developing a gene editing nanoparticle formulation for retinal degeneration diseases. Alongside his research activities, V. Francisco has experience teaching at BSc level, "Biomedical Engineering", as well as "Regenerative Medicine" and "Advanced Therapies" courses at MSc and PhD level. Throughout the years he has mentoring/tutoring >10 graduated students, and he is currently supervising/co-supervising 2 Master student and 3 PhD students. He was elected CIBB post-doctoral representatives (2016-2018), where he was involved in one evaluation of the host institution and also in the organization of a symposium for PhD students and Post-Doc researchers. V. Francisco has also contributed to several outreaching activities with the general public as well as high-school students, such as European Research Night or Science Fairs and participated in TV/radio shows as Mentes que Brilham (Porto Canal) and 90 segundos de Ciência (Antena 1).

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Identificação

Identificação pessoal

Nome completo: Vitor Manuel dos Santos Francisco

Nomes de citação

Francisco, Vitor

Identificadores de autor

Ciência ID: 7A1A-3400-E0A5

Endereços de correio eletrónico

francisco.vms@cnc.uc.pt (Profissional)

Domínios de atuação

Ciências da Engenharia e Tecnologias - Nanotecnologia
Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
Ciências Exatas - Química

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Espanhol; Castelhano	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2014/01/10 Concluído	Chemistry (Doctor) Especialização em Physical Chemistry Universidade de Santiago de Compostela, Espanha "Thermodynamic and structural studies on the interaction of guests with macrocycles" (TESE/DISSERTAÇÃO)	Approved unanimously with distinction and praise
2010/09/22 Concluído	Science and Technology of Colloids and Interfaces (Mestrado) Universidade de Santiago de Compostela, Espanha "Vesículas a partir dun complexo de inclusíon entre un calixareno e un surfactante (Supramolecular vesicles formed between a calixarene and a surfactant)" (TESE/DISSERTAÇÃO)	Excellent (10.0)
2008 Concluído	Chemistry (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Estudio cinético de una reacción autocatalítica: nitrosación del disulfuro de formamidina (Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide)" (TESE/DISSERTAÇÃO)	15

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2018/07/01 - Atual	Investigador Contratado (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015/03/01 - 2018/06/30	Pós-doutorado (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2014/03/15 - 2015/02/28	Investigador (Investigação)	Biocant Associação de Transferência de Tecnologia, Portugal

2013/01/01 - 2013/12/31	Investigador (Investigação)	Universidade de Santiago de Compostela - Campus Vida, Espanha

2012/09/01 - 2012/11/30	Investigador visitante (Investigação)	Jacobs University Bremen gGmbH, Alemanha

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2022/09/01 - Atual	Assistente convidado (Docente Ensino Superior Politécnico)	Instituto Politécnico de Coimbra, Portugal
	Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023/01/01 - 2025/12/31	Heat-induced epithelial permeability: a nanoscale-based solution for the treatment of fungal keratitis na Investigador Centro Hospitalar e Universitário de Coimbra EPE, Portugal	Centro Hospitalar e Universitário de Coimbra EPE Em curso
2023/12/20 - 2024/07/31	Contact lens modified with nanotechnology for keratoconus treatment Provas de Conceito UC by Santander Universidades Universidade de Coimbra Centro de Investigação em Engenharia dos Processos Químicos e dos Produtos da Floresta, Portugal	Banco Santander Portugal Em curso

Projeto

	Designação	Financiadores
2025/01/01 - Atual	A nanotherapeutic strategy to tackle vascular cell senescence 2023.12423.PEX Investigador responsável	Fundação para a Ciência e a Tecnologia
2023/03/01 - Atual	Targeted senolytic delivery system to treat liver cirrhosis 2022.02783.PTDC Investigador responsável Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/01/01 - Atual	Nanomedicine and trojan cells for leukemic niche intervention 2022.05946.PTDC Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - Atual	A gene editing nanoparticle formulation for retinal degeneration diseases EXPL/BIA-CEL/0989/2021 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - Atual	Enhancing epithelial permeability: a nanotechnology-based solution for epi-on corneal cross-linking EXPL/BIA-BQM/0042/2021 Investigador Universidade de Coimbra, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/06 - 2022/07/05	LIghtBRARY: A light-activatable nanoparticle library for the delivery of RNA-based therapies POCI-01-0145-FEDER-029414 Investigador responsável Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2017/01/01 - 2021/06/30	Tackling Cancer Stem Cells: a challenge and an opportunity to advance in anti-cancer therapy POCI-01-0145-FEDER-016390 Investigador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Porto, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015/07/01 - 2020/06	Enhancing Research in Ageing at the University of Coimbra eu-repo/grantAgreement/EC/H2020/669088/EU Investigador Pós-doutorado Universidade de Coimbra Faculdade de Medicina, Portugal	European Commission Concluído
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014 - 2017	Triggerable nanomaterials to modulate cell activity - NanoTrigger 307384 Bolseiro de Pós-Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	European Research Council Concluído
2014/03/15 - 2016/03/14	Personalized 3D vascular constructs for toxicity assessment - VASCTOX PTDC/SAU- TOX/121887/2010 Bolseiro de Pós-Doutoramento Biocant Associação de Transferência de Tecnologia, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012/01/01 - 2014/12/31	Reactivity in colloidal systems derived from supramolecular aggregates CTQ2011-22436 Bolseiro de Doutoramento Universidade de Santiago de Compostela, Espanha	Gobierno de España Agencia Estatal de Investigación Concluído
2010/08/10 - 2013/09/30	Self-assembly of supramolecular aggregates 10PXIB209113PR Bolseiro de Doutoramento Universidade de Santiago de Compostela, Espanha	Xunta de Galicia Concluído

Produções

Publicações

Artigo em revista	Francisco, Vitor; Andreia Marques; David Sanfeliu-Redondo; Ines Tomé; Rosa, Susana; Jordi Gracia-Sancho; Ferreira, Lino. "Enhancing Safety and Efficacy of Senolytic Therapies with Advanced Controlled Release Strategies". Nature Communications (2025): Submetido Quartin, Emanuel; Rosa, Susana; Gonzalez-Anton, Sara; Mosteo Lopez, Laura; Francisco, Vitor; Duarte, Delfim; Lo Celso, Cristina; Pires das Neves, Ricardo; Ferreira, Lino. "Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche". Bioactive Materials 34 (2024): 311-325. http://dx.doi.org/10.1016/j.bioactmat.2023.12.017. 10.1016/j.bioactmat.2023.12.017 Marta Machado-Pereira; Alba Grayston; Miguel Garcia-Gabilondo; Francisco, Vitor; Cristóvão, Ana; Marto, João; Ferreira, Lino; et al. Autor correspondente: Ferreira, Raquel. "Retinoic Acid-Loaded Nanoparticles Promote Neurovascular Protection in Stroke". Stroke (2023): https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.041839?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Rodrigues, Artur Filipe; Rebelo, Catarina; Simões, Susana; Paulo, Cristiana; Pinho, Sónia; Francisco, Vítor; Ferreira, Lino. Autor correspondente: Francisco, Vítor. "A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts". Advanced Science 10 5 (2022): 2205475. http://dx.doi.org/10.1002/advs.202205475. 10.1002/advs.202205475 Kauppila, Maija; Ståhlberg, Roosa; Francisco, Vitor; Ferreira, Lino; Skottman, Heli. "Multi-parametric surface plasmon resonance-based intake quantification of label-free light-activated nanoparticles by therapeutic limbal stem cells for corneal blindness". Nano Select 3 8 (2022): 1232-1241. http://dx.doi.org/10.1002/nano.202200027. 10.1002/nano.202200027 Tomé, Inês; Francisco, Vitor; Fernandes, Hugo; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "High-throughput screening of nanoparticles in drug delivery". APL Bioengineering 5 3 (2021): 031511. http://dx.doi.org/10.1063/5.0057204. 10.1063/5.0057204 Estronca, Luís; Francisco, Vitor; Pitrez, Patrícia; Honório, Inês; Carvalho, Lara; Vazão, Helena; Blersch, Josephine; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions". Nanoscale Horizons (2021): http://dx.doi.org/10.1039/d0nh00550a. 10.1039/d0nh00550a Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies". Methods (2020): http://dx.doi.org/10.1016/j.ymeth.2020.12.002. 10.1016/j.ymeth.2020.12.002 Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Pinto, Sandra; Simões, Susana; Rai, Akhilesh; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1a (HIF-1a)". Nanoscale 12 18 (2020): 9935-9942. http://dx.doi.org/10.1039/c9nr10503d. 10.1039/c9nr10503d Blersch, Josephine; Francisco, Vitor; Rebelo, Catarina; Jiménez-Balsa, Adrian; Antunes, Helena; Gonzato, Carlo; Pinto, Sandra; et al. "A light-triggerable nanoparticle library for the controlled release of non-coding RNAs". Angewandte Chemie International Edition (2019): http://dx.doi.org/10.1002/anie.201911398. 10.1002/anie.201911398 Francisco, Vitor; Lino, Miguel; Ferreira, Lino. "A near infrared light-triggerable modular formulation for the delivery of small biomolecules". Journal of Nanobiotechnology 17 1 (2019): http://dx.doi.org/10.1186/s12951-019-0530-y. 10.1186/s12951-019-0530-y Garcia-Rio, Luis; Basílio, Nuno; Francisco, Vitor. "Counterion effect on sulfonatocalix[n]arene recognition". Pure and Applied Chemistry 0 0 (2019): http://dx.doi.org/10.1515/pac-2019-0305. 10.1515/pac-2019-0305 Jiménez-Balsa, Adrián; Pinto, Sandra; Quartin, Emanuel; Lino, Miguel M.; Francisco, Vitor; Ferreira, Lino. "Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules". Bioconjugate Chemistry 29 5 (2018): 1485-1489. http://dx.doi.org/10.1021/acs.bioconjchem.7b00820. 10.1021/acs.bioconjchem.7b00820 Gómez-González, Borja; Francisco, Vitor; Montecinos, Rodrigo; García-Río, Luis. "Investigation of the binding modes of a positively charged pillar[5]arene: internal and external guest complexation". Organic & Biomolecular Chemistry 15 4 (2017): 911-919. http://dx.doi.org/10.1039/c6ob02573k. 10.1039/c6ob02573k Lavande, Nitin; Acuña, Angel; Basílio, Nuno; Francisco, Vitor; Malkhede, Dipalee D.; Garcia-Rio, Luis. "A journey from calix[4]arene to calix[6] and calix[8]arene reveals more than a matter of size. Receptor concentration affects the stability and stoichiometric nature of the complexes". Physical Chemistry Chemical Physics 19 21 (2017): 13640-13649. http://dx.doi.org/10.1039/c7cp01889d. 10.1039/c7cp01889d Costa, Catarina; Francisco, Vitor; Silva, Sandra G.; do Vale, M. Luísa C.; García-Río, Luis; Marques, Eduardo F.. "Supramolecular self-assembly between an amino acid-based surfactant and a sulfonatocalixarene driven by electrostatic interactions". Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 (2015): 71-78. http://dx.doi.org/10.1016/j.colsurfa.2015.03.054. 10.1016/j.colsurfa.2015.03.054 Gómez, Borja; Francisco, Vitor; Fernández-Nieto, Fernando; Garcia-Rio, Luis; Martín-Pastor, M.; Paleo, M. Rita; Sardina, F. Javier. "Host-Guest Chemistry of a Water-Soluble Pillar[5]arene: Evidence for an Ionic-Exchange Recognition Process and Different Complexation Modes". Chemistry - A European Journal 20 38 (2014): 12123-12132. http://dx.doi.org/10.1002/chem.201403194. 10.1002/chem.201403194 Francisco, Vitor; Basílio, Nuno; García-Río, Luis. "Ionic Exchange in p-Sulfonatocalix[4]arene-Mediated Formation of Metal–Ligand Complexes". The Journal of Physical Chemistry B 118 17 (2014): 4710-4716. Publicado • 10.1021/jp502097q Francisco, Vitor; Garcia-Rio, Luis. Autor correspondente: Francisco, Vitor. "Interaction of Bolaform Surfactants with p-Sulfonatocalix[4]Arene: The Role of Two Positive Charges in the Binding". Langmuir 30 23 (2014): 6748-6755. Publicado • 10.1021/la501337c Basilio, Nuno; Gómez, Borja; Garcia-Rio, Luis; Francisco, Vitor. "Using Calixarenes To Model Polyelectrolyte Surfactant Nucleation Sites". Chemistry - A European Journal 19 14 (2013): 4570-4576. Publicado • 10.1002/chem.201203377 Figueira-González, María; Francisco, Vitor; García-Río, Luis; Marques, Eduardo F.; Parajó, Mercedes; Rodríguez-Dafonte, Pedro. "Self-Aggregation Properties of Ionic Liquid 1,3-Didecyl-2-methylimidazolium Chloride in Aqueous Solution: From Spheres to Cylinders to Bilayers". The Journal of Physical Chemistry B 117 10 (2013): 2926-2937. Publicado • 10.1021/jp3117962 Basilio, Nuno; Francisco, Vitor; Garcia-Rio, Luis. "Aggregation of p-Sulfonatocalixarene-Based Amphiphiles and Supra-Amphiphiles". International Journal of Molecular Sciences 14 2 (2013): 3140-3157. Publicado • 10.3390/ijms14023140 Francisco, Vitor; Piñeiro, Angel; Nau, Werner M.; García-Río, Luis. "The "True" Affinities of Metal Cations to p-Sulfonatocalix[4]arene: A Thermodynamic Study at Neutral pH Reveals a Pitfall Due to Salt Effects in Microcalorimetry". Chemistry - A European Journal 19 52 (2013): 17809-17820. Publicado • 10.1002/chem.201302365 Francisco, Vitor; Basilio, Nuno; García-Río, Luis. "Counterion Exchange as a Decisive Factor in the Formation of Host:Guest Complexes by p-Sulfonatocalix[4]arene". The Journal of Physical Chemistry B 116 17 (2012): 5308-5315. Publicado • 10.1021/jp301290u Basílio, Nuno; Francisco, Vitor; García-Río, Luis. "Independent Pathway Formation of Guest–Host in Host Ternary Complexes Made of Ammonium Salt, Calixarene, and Cyclodextrin". The Journal of Organic Chemistry 77 23 (2012): 10764-10772. Publicado • 10.1021/jo302074x Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis; Leis, Jose R.; Maques, Eduardo F.; Vázquez-Vázquez, Carlos. "Novel catanionic vesicles from calixarene and single-chain surfactant". Chemical Communications 46 35 (2010): 6551-6551. Publicado • 10.1039/c0cc01806f Francisco, Vitor; Garcia-Rio, Luis; António Moreira, José; Stedman, Geoffrey. "Kinetic study of an autocatalytic reaction: nitrosation of formamidine disulfide". New Journal of Chemistry 32 12 (2008): 2292-2292. Publicado • 10.1039/b810761k
Poster em conferência	Henriques, Mauro; Andreia Marques; Ines Tomé; Francisco, Vitor; Ferreira, Lino. "Engineering nanoformulations for senotherapeutics delivery". Trabalho apresentado em 3rd RESETageing conference, 2024. Henriques, Mauro; Marques, Andreia; Ines Tomé; Francisco, Vitor; Lino da Silva Ferreira. "Engineering nanoformulations for senotherapeutics delivery". Trabalho apresentado em 3rd RESETageing Conference, 2023. Pitrez, João; Marques, Andreia; Tomé, Inês; Rosa, Susana; Francisco, Vitor; Ferreira, Lino. "Senescence in liver sinusoidal endothelial cells: implications for age-related liver changes". Trabalho apresentado em 3rd RESETageing Conference, 2023. Tomé, Inês; Rosa, Susana; Sanfeliu-Redondo, D.; Aristu-Zabalza, P.; Vizioli, M.G.; Pitrez, P.; Gracia-Sancho, Jordi; et al. "Targeting cell senescence in the blood-brain barrier with senotherapeutic nanoparticles". Trabalho apresentado em 3rd RESETageing Conference, 2023. H.R. Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. "A Nanoparticle-based Innovative Senotherapy". Trabalho apresentado em European Tissue Repair Society (ETRS) and Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) Joint Meeting, 2023. Tomé, Inês; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Suana Rosa; Pitrez, Patricia R.; Gracia-Sancho, Jordi; Diana Jurk; Francisco, Vitor; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Trabalho apresentado em 33rd Annual Conference of the European Society for Biomaterials, 2023. Inês Tomé Ribeiro; Rosa, Susana; Sanfeliu-Redondo, David; Maria Grazia Vizioli; Pitrez, Patrícia; Gracia-Sancho, Jordi; Francisco, Vitor; Diana Jurk; Ferreira, Lino. "Targeting the senescence program in the blood brain barrier with senotherapeutic nanoparticles". Trabalho apresentado em 33rd Annual Conference of the European Society for Biomaterials, 2023. Francisco, Vitor; Rodrigues, Artur Filipe; Rebelo, Catarina; Paulo, Cristiana; Rita Pereira; Simões, Susana; Pinho, Sonia L. C:; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "A nano formulation for targeted mRNA delivery to tackle fibrotic diseases". Trabalho apresentado em Ageing Without Borders, 2022. Helena R Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. Autor correspondente: Helena R Aires. "Senolysis as a therapeutic approach for cardiovascular aging". Trabalho apresentado em Ageing Without Borders, 2022. Monteiro, Luís; Pitrez, Patricia R.; Correia-Santos, Simão; Nicola Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; et al. Autor correspondente: Monteiro, Luís. "Disease modeling and drug screening on cardiomyocytes derived from Hutchinson-Gilford Progeria Syndrome- induced pluripotent stem cells". Trabalho apresentado em The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022. Rodrigues, Artur Filipe; Catarina Rebelo; Pinho, Sonia L. C:; Francisco, Vitor; Ferreira, Lino. Autor correspondente: Francisco, Vitor. "High-throughput screening of combinatorial polymers library of nanoparticles for controlled delivery of mRNA". Trabalho apresentado em XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020. Francisco, Vitor; Lino da Silva Ferreira. "Near-infrared light triggered release of bioactive molecules from supramolecular modified gold nanorods". Trabalho apresentado em 29th Annual Meeting of the European Society for Biomaterials, 2018. Francisco, Vitor; Lino da Silva Ferreira. "Near-infrared light triggered release of bioactive molecules from supramolecular modified gold nanorods". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018. 10.1109/wrap.2017.8468598 Francisco, Vitor; Costa, Catarina; Vale, Maria Luisa C.; Garcia-Rio, Luis; Marques, Eduardo F.. "Supramolecular aggregation in cationic/anionic mixtures of calixarene and serine-based surfactants". Trabalho apresentado em 5th Iberian Meeting on Colloids and Interfaces, 2013. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis. "Host:Guest binding constant influenced by the host counterion". Trabalho apresentado em 3rd Portuguese Young Chemists Meeting, 2012. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis. "Influence of counterion in the formation of host:guest complexes by p-sulfonatocalix[4]arene". Trabalho apresentado em 1th International Conference on Calixarenes, 2011. Francisco, Vitor; Basilio, Nuno; Garcia-Rio, Luis; Marques, Eduardo F.. "Colloidal structures from self-assembling of host-guest complexes". Trabalho apresentado em 24th Conference of the European Colloid and Interface Society, 2010.
Resumo em conferência	Luis Monteiro; Pitrez, Patricia R.; N Dark; Deolinda Santinha; Xavier, Nissan; Sardão, Vilma; Francisco, Vitor; et al. "Modeling and drug screening on human cardiomyocytes derived from hutchinson-gilford progeria syndrome induced pluripotent stem cells". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022. Publicado Luis Monteiro; Patricia Pitrez; S. Correia Santos ; Sardão, Vilma; Francisco, Vitor; Cortes, Luisa; Ferreira, Lino. "Cardiovascular & metabolic diseases modeling of ageing in human cardiomyocytes derived from induced pluripotent stem cells". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Bari, 2022. Publicado Ricardo Pires das Neves; Quartin, Emanuel; González Antón, Sara; Rosa, Susana; Francisco, Vitor; Mosteo, Laura; Duarte, Delfim; Lo Celso, Cristina ; Ferreira, Lino. "Cells as therapeutical vehicles for the delivery of light sensitive retinoic acid nanoparticles for leukemic niche modulation". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021. Publicado Francisco, Vitor; Josephine, Blersch; Rebelo, Catarina; Ferreira, Lino. "High-throughput screening of nanoparticles to efficiently deliver non-coding RNA". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Coimbra, 2021. Publicado Estronca, LM; Francisco, Vitor; Ferreira, Lino. "Development of Cell Platforms derived from induced pluripotent stem cells for screening toxicity of nanomaterials". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021. Publicado Moreira, José A.; García-Río, Luís; Stedman, Geoffrey; Francisco, Vitor. "The kinetics and mechanism of the reaction of nitrous acid with formamidine disulfide". Trabalho apresentado em XIX IUPAC Conference on Physical Organic Chemistry, Santiago de Compostela, 2008. Publicado

Propriedade Intelectual

Patente

Francisco, Vitor Manuel dos Santos; García-Río, Luis; Basilio, Nuno; Leis, Jose R.. 2011. "Lyophilisable vesicles without cryoprotectant". Espanha.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/06/24	Nanoformulations to tackle senescent cells	10th Iberian Meeting on Colloids and Interfaces University of Coimbra (Coimbra, Portugal)
2024/05/15	Nanobiotechnology in biomedical engineering	15a Jornadas de Engenharia Biomédica 2024 (Coimbra, Portugal)
2023/12/07	Biodegradable anti-senescence nanoparticles	3rd RESETageing Conference University of Coimbra (Coimbra, Portugal)
2023/09/04	Engineering nanoparticles for an efficient delivery of senolytics to the aged liver	33rd Annual Conference of the European Society for Biomaterials European Society for Biomaterials (Davos, Suiça)
2023/06/29	Senotherapeutic nanoparticles to target senescent cells in the liver	DGfA Meeting Leibniz Institute on Aging (Jenna, Alemanha)
2022/10/13	A nanotechnology-based solution for EPI-ON corneal cross-linking	23rd European Association for Vision and Eye Research EVER (Valencia, Espanha)
2022/01/31	Light responsive nanoparticles for drug delivery	International Symposium on Emerging Materials for Biomedical Engineering (EMBE2022) PDPM IIITDM (Índia)
2021/09/07	Engineering nanoparticles for targeted delivery of RNA-based therapies	31st Conference of the European Society for Biomaterials (ESB) European Society for Biomaterials (Porto, Portugal)
2021/06/10	High-throughput screening of nanoparticles to efficiently deliver non-coding RNA	55th ESCI Annual Scientific Meeting ESCI (Barcelona, Espanha)
2020/01/22	Controlled delivery of siRNA via photodegradable polymeric nanoparticle library	XIII Spanish-Portuguese Conference on Controlled Drug Delivery Controlled Release Society (Santiago de Compostela, Espanha)
2019/05/22	Efficient non-coding RNA delivery in wound healing by photo-triggerable nanoparticles	53rd Annual Scientific Meeting of the European Society for Clinical Investigation Universidade de Coimbra (Coimbra, Portugal)
2019/03/14	Advances in Stem Cell Research and Therapeutics: an ethical dilemma?	VII AEICBAS Biomedical Congress AEICBAS (Porto, Portugal)
2017/10/12	Light-triggerable nanoparticles for the efficient in-vivo non-coding RNA delivery in wound healing	The Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Lisbon, Portugal)
2014/07/22	Supramolecular systems based on surfactants and p-sulfonatocalix[4]arene	20th International Symposium on Surfactants in Solution University of Coimbra (Coimbra, Portugal)
2013/06/26	Micellar shape transition in an imidazolium based-surfactant	5th Iberian Meeting on Colloids and Interfaces University of San Sebastian (Donostia-San Sebastian)
2012/01/13	Estudio de ITC de la influencia de la sal en la complejacion de un cation amonio por el p-sulfonatocalix[4]arene.	III Encuentro Gallego de Cinetica y Catalisis University of Ourense (Ourense, Espanha)
2011/07/13	Vesicular aggregates from supramolecular surfactants	4th Iberian Meeting on Colloids and Interfaces Faculty of Science - University of Porto (Porto, Portugal)
2008/07/13	Kinetic Study of an Autocatalytic Reaction: Nitrosation of Formamidine Disulfide	XIX IUPAC Conference on Physical Organic Chemistry University of Santiago de Compostela (Santiago de Compostela, Espanha)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2024/09/15 - Atual	Development and Validation of a Medical Device Based on Nanotechnology for the Treatment of Corneal Diseases Coorientador de Patricia Nápoles	Engenharia Biomédica (Mestrado) Universidade de Coimbra, Portugal
2024/09/01 - Atual	A senolytic delivery system to target the blood brain barrier Coorientador de Anis Shahzad	Ciências da Saúde (Doutoramento) Universidade de Coimbra, Portugal
2020/11/30 - Atual	Reducing senescent cell burden in aging with nanoparticles Coorientador de Andreia Marques	Ciências da Saúde (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/01/01 - Atual	A senolytic delivery system able to cross the blood brain barrier Coorientador de Inês Tomé	Ciências da Saúde (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2023/10/01 - 2024/07/22	Development of pharmacological nanoformulations to eliminate senescent cells Coorientador de Mauro Henriques	Bioengenharia (Mestrado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Faculdade de Engenharia, Portugal
2021/06/01 - 2024/07/22	Polymeric nanoparticles for gene editing Coorientador	PhDExperimental Biology and Biomedicine (PDBEB) (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2022/10/01 - 2023/12/12	Targeted senolytic delivery system to treat liver cirrhosis Orientador de João Pedro Oliveira Santos Pitrez	Engenharia Química e Biológica (Mestrado) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/09/01 - 2023/09/15	A nanotechnology-based solution for enhancing corneal permeability Coorientador de João Pedro Cidra	Ciências de Engenharia Biomédica (Mestrado) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra, Portugal
2022/09/01 - 2023/07/15	Improve corneal permeability in keratoconus treatment: a solution based on nanotechnology Coorientador de Rita Isabel Martins Pais	Investigação Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/03/01 - 2022/07/21	Tackling senescence in brain aging Orientador de Mauro Henriques	Engenharia Biológica (Licenciatura/Bacharelato) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/01/01 - 2021/12/31	Light-triggerable delivery of mRNA nanoparticles Orientador de Catarina Rebelo	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/09/01 - 2020/12/15	Development of nanoparticles to target senescent cells Coorientador de Ricardo Casqueiro	Investigação Biomédica (Mestrado) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/06/01 - 2020/04/30	mRNA nanoparticles to improve wound healing Orientador de Artur Filipe Rodrigues	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/12/06 - 2023/12/07	3rd RESETageing conference (2023/12/06) Conferência (Membro da Comissão Organizadora)	Universidade de Coimbra, Portugal
2019/06/28 - 2019/06/29	Ageing: models, mechanisms and therapies (2019/06/28 - 2019/06/29) Conferência (Membro da Comissão Organizadora)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06/27 - 2018/06/27	"Ageing: models and therapies" (2018/06/27 - 2018/06/27) Oficina (workshop)	Universidade de Coimbra, Portugal
2018/03/23 - 2018/03/23	Overcoming Challenges in Scientific Careers, the Biomedical Research Post-Doctoral Forum@UC (2018/03/23 - 2018/03/23) Simpósio (Coorganizador)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2008/07/13 - 2008/07/18	XIX IUPAC Conference on Physical Organic Chemistry (2008/07/13 - 2008/07/18) Conferência (Membro da Comissão Organizadora)	Universidade de Santiago de Compostela, Espanha

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/01/16	Breaking the classic antibiotic barrier: Micro and nanoparticles for Helicobacter pylori management Arguente principal	Diana Fonseca (Doutoramento) Universidade do Porto, Portugal
2023/07/28	Targeted polymeric nanoparticles for the treatment of fibrosis Arguente principal	Rita Durão Rosa Pereira (Mestrado) Universidade de Coimbra, Portugal
2023/03/13	Evaluation of the presence of nitrosamines in pharmaceuticals (Avaliação da presença de nitrosamines em medicamentos) Arguente principal	Filipa Alexandra Duque Fonseca (Mestrado) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/07/19	Development of nanoparticles for delivery of senolytics at the blood-brain barrier Arguente	Mauro Henriques (Outro) Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2021/07/07	Evaluation of the effect of NIR radiation on the cornea and retina Arguente principal	Jéssica Monteiro (Outro) Universidade de Coimbra, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/09/05 - Atual	Frontiers in Biomaterials Science for Regenerative Therapies	Frontiers
2022/03/25 - Atual	Frontiers in Chemistry
2020/07/21 - Atual	Experimental Results	Cambridge University Press

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2023/02/21 - Atual	Biochemistry and Molecular Biology	Engenharia Biomédica (Licenciatura)	Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2022/09/01 - Atual	Cell and Tissue Biology	Engenharia Biomédica (Licenciatura)	Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2018/09/26 - Atual	Regenerative Medicine	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2018/05/07 - Atual	PhD Programme in Experimental Biology and Biomedicine (PDBEB)	Doctoral Program in Experimental Biology and Biomedicine (Doutoramento)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Entrevista / Programa (rádio / tv)

	Programa	Tema
2021/01/13 - Atual	90 segundo de Ciência	Método inovador e sensível à luz para a entrega de moléculas em doenças da pele
2020/02/18 - 2020/02/18	Mentes que Brilham

Membro de associação

	Nome da associação	Tipo de participação
2019/07/21 - Atual	Controlled Release Society (CRS)
2019/05/22 - Atual	European Society for Clinical Investigation (ESCI)
2018/09/09 - Atual	European Society for Biomaterials (ESB)

Tutoria

	Tópico	Nome do aluno
2021/03/01 - Atual	Nanoparticles to target senescent vascular cells	Helena Aires
2020/10/01 - Atual	Synthesis and role of piezoelectric nanoparticles on cardiomyocytes	Luis Monteiro
2015/01/01 - Atual	A light-triggerable nanocarrier library to modulate cell activity	Josephine Blersch
2021/01/04 - 2021/01/29	Synthesis and characterisation of an enzyme-responsive delivery system	Jakub Misturik
2020/06/29 - 2020/07/18	Senoterapeutic drug delivery systems	Filipe de Campos Hipolito Pedroso Mateus
2018/03/05 - 2018/10/31	A light-activatable nanoparticle library for the delivery of RNA-based therapies	Filipe Coelho
2017/09/01 - 2018/03/31	Synthesis of light sensitive nanoparticles for drug delivery	Mehrzad Zargarzadeh
2016/10/01 - 2017/10/31	Characterisation of a light sensitive nanoparticle library	Malwina Kotowicz

Distinções

Prémio

2024	Best innovation in Acelera@UC 2024 Best innovation in Acelera@UC 2024 - Training Programme for Entrepreneurs, Project: NanoLensTech Universidade de Coimbra, Portugal
2023	Winner of 2nd edition of BiotechSTARS BioBOOST (Bio-entrepreneurship Mentoring Program) - Project NanoLensTech Biocant Associação de Transferência de Tecnologia, Portugal
2022	Prémio de Investigação Centro Hospitalar e Universitário de Coimbra - Projeto de investigação translacional (Heat-induced epithelial permeability: A nanoscale-based solution for the treatment of fungal keratitis) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2020	Best Poster at XIII Spanish-Portuguese Conference on Controlled Drug Delivery Spanish Portuguese Local Chapter (SPLC-CRS), Espanha

Outra distinção

2021	Feature Article - https://doi.org/10.1063/5.0057204 American Institute of Physics (AIP), Estados Unidos
2017	HOT Article PCCP - https://doi.org/10.1039/C7CP01889D Royal Society of Chemistry, Reino Unido
2014	Postdoctoral Research Fellowship Fundação para a Ciência e a Tecnologia, Portugal
2008	PhD Fellowship Fundação para a Ciência e a Tecnologia, Portugal