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I started my research career with my master and PhD in the department of organic Chemistry at the Univ. of Santiago de Compostela under the supervision of R. Riguera and E. Fernandez-Megía. I worked in organic synthesis applied to biopolymers for drug delivery and in nuclear magnetic resonance (NMR). I developed the synthesis of PEG grafted chitosan with bioactive molecules at the end of the PEG for targeted drug delivery (collaboration with Maria Jose Alonso). The success of this approach is demonstrated in 12 publications (2 with more than 170 cites) where these polymers facilitated the delivery of peptides and DNA. My PhD was interdisciplinary covering also studies on aggregation and flexibility of chitosan and dendrimers: Biomacromolecules 2010, 11, 2079; PCCP 2010, 12, 6587, Mol. Pharm. 2013, 10, 3225–3231) and analytical techniques (novel NMR characterization methods: J. Am. Chem. Soc. 2007, 129, 15164-15173; Carbohydr. Polym. 2005, 61, 155) After my PhD I obtained a Barrie de la Maza fellow and moved to Axel Müller´s group in Germany, one of most important groups engaged in the formation nanostructures based on block copolymers. There I combined this knowledge with my background in polysaccharides and I described the oxime click chemistry for the synthesis of polysaccharide diblock copolymers and the formation of nanosized interpolyelectrolyte complexes with a PEG corona or a polysaccharide corona from these copolymers (Chem. Commun. 2012, 48, 3781, Soft Matter 2013, 9, 4297, Pol. Chem.2013, 4, 2278). After the time in Bayreuth I received a postdoctoral contract (USC) to work at the 3bs research group (Univ.of Minho). Here I followed my independent research line preparing diblock star and brush-like copolymers of glycosaminoglycans for protein delivery and stem cell culture (J. Mat. Chem. B 2014, 2 4177, J. Am. Chem. Soc. 2015, 137, 576, Acta Biomaterialia,2017, 63, 283, Chem. an Eur. Journal 2018, 24, 14341; Chem. Sci. 2019,10 , 2385). I am also starting a new research line in the discovery of new sulfation patterns in GAG and GAG-like polysaccharides from marine origin (Carbohydr. Polym. 2017, 157,31 and 2019, 2019, 222, 114999) in collaborations with the CSIC in Vigo and the company Pacific Biotech). In 2015 I obtained a FCT contract together with (50.000 euros) for research. I have obtained in 2018 another research project (239.000 euros) and a new contract (6 years) from FCT. In summary my research is interdisciplinary between organic chemistry, pharmaceutical sciences using and improving advanced analytical tools and always focusing in polysaccharides. My research combines basic science studies in chemistry with applied science in the field of biomedicine. I have 44 publications in scientific journals with a total of 1551 citations, 1 paper as last author, 15 papers as first author, 7 papers as corresponding author, 3 review publications and a book chapter, my h-index is 18. I have performed more than 9 years of research in institutions of Europe and obtained for this funding for my independent research from Spanish and Portuguese agencies. I have participated in 3 european projects and been founded for a Postdoctoral stay (Max Plank). I have supervised 3 master students in Germany and I am supervising 2 postodcs and 3 PhD in Portugal. I am officially supervisor of one PhD student since 2016.
Identificação

Identificação pessoal

Nome completo
Ramon Novoa-Carballal
Data de nascimento
1979/11/10
Género
Masculino

Nomes de citação

  • Novoa-Carballal, Ramon

Identificadores de autor

Ciência ID
8B16-96BC-DB30
ORCID iD
0000-0003-0422-8048

Domínios de atuação

  • Ciências Exatas - Química - Ciência de Polímeros
Formação
Grau Classificação
2009/12/04
Concluído
Programa Oficial de Doctorado en Química Orgánica (Doctor)
Universidade de Santiago de Compostela Facultade de Química, Espanha
"Quitosano y Quitosano-g-PEG: Estudios sintéticos, caracterización, dinámica y agregación. Aplicaciones a transporte de fármacos" (TESE/DISSERTAÇÃO)
Sobresaliente Cum Laude
2004/07/01
Concluído
Master en Quimica Orgánica (Mestrado)
Universidade de Santiago de Compostela Facultade de Química, Espanha
"Synthesis of new biopolymers for drug delivery: Chitosan-g-PEG" (TESE/DISSERTAÇÃO)
Sobresaliente
2002/09/15
Concluído
Quimica (Licenciatura)
Universidade de Santiago de Compostela Facultade de Química, Espanha
"n/a" (TESE/DISSERTAÇÃO)
n/a
Percurso profissional

Outros

2015/04/16 - Atual Assistant researcher (FCT), FCT researcher 2015 and CEEC-IND 2017
Universidade do Minho, Portugal
2013/04/15 - 2015/04/15 Investigador Postdoctoral, Financiamento da Xunta de Galicia
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2012/05/01 - 2013/10/31 Full position as postdoctoral researcher
Universität Bayreuth, Alemanha
2010/11/01 - 2012/04/30 Postdoctoral researcher with external Fellowship (Barrie de la Maza)
Fundación Pedro Barrié de la Maza, Espanha
2009/12/06 - 2010/09/30 Investigador postdoctoral
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2008/03/01 - 2009/12/01 Investigador Predoctoral
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2004/02/01 - 2008/01/31 Becario FPU (Beca Predoctoral Ministerio de Educación de Espanha)
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2006/09/06 - 2006/12/06 PhD. Intership at Stockholm University
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2005/07/05 - 2005/09/05 Ph.D Intership at Imperial College London
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2003/04/01 - 2004/01/31 Becario Predoctoral Xunta de Galicia
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
Projetos

Projeto

Designação Financiadores
2018 - 2021/06/30 RECONTRUCÇAO DA NANOESTRUCTURA DA CARTILAGEM COMPOLIMEROS EM PENTE MIMETICOS DE PROTEOGLICANOS
PTDC/QUI-POL/28117/2017
Investigador responsável
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2020/04/15 SWEET&NANO-ARCHITECTURES
IF/00373/2014/CP1212/CT0013
Investigador responsável
Portuguese Science Foundation
2016 - 2019/09/30 Instituto de Bioingeniería en Red para el Envejecimiento Saludable (IBEROS)
0245_IBEROS_1_E
Investigador
Universidade do Minho, Portugal

Universidade de Santiago de Compostela, Espanha

Universidade do Porto, Portugal

Universidade de Vigo, Espanha

Universidade da Coruña, Espanha
Interreg Europe
2016 - 2018/12/31 CytonanoHeal
ENMed/0001/2015
Investigador
Universidade do Minho, Portugal

Universitat Politècnica de Catalunya, Espanha
Fundação para a Ciência e a Tecnologia
2010 - 2012/12/31 Aplicaciones Biomédicas de Copolímeros de Bloque PEG-Dendrímero
CTQ2009-10963
Investigador
Universidade de Santiago de Compostela, Espanha
Gobierno de España Ministerio de Ciencia Innovación y Universidades
2006 - 2009/12/30 Sulfatación via Click Chemistry de Copolímeros de Bloque PEG-Dendrímero. Determinación de la Actividad Anticoagulante y Antiviral (HIV)
PGIDIT06PXIB209058PR
Bolseiro de Doutoramento
Xunta de Galicia
2005 - 2008/12/30 Diseño y Síntesis de Nuevos Biopolímeros como Vectores en Terapia Génica: Aplicación a la Liberación Intracelular de siRNA
NAN2004-09230-C04-03
Bolseiro de Doutoramento
Universidade de Santiago de Compostela, Espanha
Gobierno de España Ministerio de Ciencia Innovación y Universidades
2006 - 2008/09/30 Copolímeros de Bloque Glicodendrímero-PEG. Diseño, Síntesis y Aplicación al Transporte de Fármacos e Inhibición de Agentes Patógenos
CTQ2006-12222/BQU
Bolseiro de Doutoramento
Universidade de Santiago de Compostela, Espanha
Xunta de Galicia
2004 - 2007/06/03 Nuevas estrategias terapéuticas en enfermedades respiratorias: diseño, síntesis y caracterización de nuevos polímeros biocompatibles
NAN2004-09230-C04-03/)
Bolseiro de Doutoramento
Universidade de Santiago de Compostela, Espanha
Xunta de Galicia
2005 - 2006/12/30 Copolímeros de Bloque Glicodendrímero-PEG. Diseño, Síntesis y Aplicación al Transporte de Fármacos e Inhibición de Agentes Patógenos
CTQ2005-00874
Bolseiro de Doutoramento
Gobierno de España Ministerio de Ciencia Innovación y Universidades
2003 - 2006/07/16 Recoñocemento de quiralidade por RMN: desenvolvemento de procedementos
PGIDIT03PXIC20908PN
Bolseiro de Mestrado
Universidade de Santiago de Compostela, Espanha
Xunta de Galicia
2004 - 2004/12/31 Diseño y Síntesis de Glicodendrímeros Modificados con Poli(etilen glicol).
CTQ2004-08106/BQU
Bolseiro de Doutoramento
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
Gobierno de España Ministerio de Ciencia Innovación y Universidades
Produções

Publicações

Artigo em revista
  1. Almeida, A.; Araújo, M.; Novoa-Carballal, R.; Andrade, F.; Gonçalves, H.; Reis, R.L.; Lúcio, M.; Schwartz, S.; Sarmento, B.. "Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs". Materials Science and Engineering C 112 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082759835&partnerID=MN8TOARS.
    10.1016/j.msec.2020.110920
  2. Martin-Pastor, M.; Ferreira, A. S.; Moppert, X.; Nunes, C.; Coimbra, M. A.; Reis, R. L.; Guezennec, J.; Novoa-Carballal, Ramon. "Structure, rheology, and copper-complexation of a hyaluronan-like exopolysaccharide from Vibrio". 222 (2019): 114999. https://doi.org/10.1016/j.carbpol.2019.114999.
    Martin-Pastor M., Ferreira A. S., Moppert X., Nunes C., Coimbra M. A., Reis R. L., Guezennec J., Novoa-Carvallal R. Structure, rheology, and copper-complexation of a hyaluronan-like exopolysaccharide from Vibrio, Carbohydrate Polymers, Vol. 222, pp. 11499
  3. Roi Lopez-Blanco; Marcos Fernandez-Villamarin; Sorel Jatunov; Novoa-Carballal, Ramon; Eduardo Fernandez-Megia. "Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles". Polymer Chemistry 10 34 (2019): 4709-4717. http://dx.doi.org/10.1039/C9PY00727J.
    Publicado
  4. Vázquez, José A.; Fraguas, J.; Novoa-Carballal, Ramon; Reis, R. L.; Pérez-Martín, Ricardo I.; Valcarcel, J.. "Optimal isolation and characterisation of chondroitin sulfate from rabbit fish (Chimaera monstrosa)". Carbohydrate Polymers 210 (2019): 302-313. https://doi.org/10.1016/j.carbpol.2019.01.075.
    José V. A., Fraguas J., Novoa-Carvallal R., Reis R. L., Ricardo P. M. I., Valcarcel J. Optimal isolation and characterisation of chondroitin sulfate from Rabbit fish (Chimaera monstrosa), Carbohydrate Polymers, Vol. 210, pp. 302-313, doi:10.1016/j.carbpol
  5. Alexandra Brito; Yousef M. Abul-Haija; Diana Soares da Costa; Ramon Novoa-Carballal; Rui L. Reis; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva. "Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles". Chemical Science (2019): https://doi.org/10.1039/C8SC04361B.
    10.1039/C8SC04361B
  6. Teijeiro-Valiño, C.; Novoa-Carballal, R.; Borrajo, E.; Vidal, A.; Alonso-Nocelo, M.; de la Fuente Freire, M.; Lopez-Casas, P.P.; et al. "A multifunctional drug nanocarrier for efficient anticancer therapy". Journal of Controlled Release 294 (2019): 154-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058516543&partnerID=MN8TOARS.
    10.1016/j.jconrel.2018.12.002
  7. José A. Vázquez; Javier Fraguas; Ramon Novoa-Carballal; Rui L. Reis; Luis T. Antelo; Ricardo Perez-Martin; Jesus Valcarcel. "Isolation and Chemical Characterization of Chondroitin Sulfate from Cartilage By-Products of Blackmouth Catshark (Galeus melastomus)". Marine Drugs (2018): http://www.mdpi.com/1660-3397/16/10/344.
    10.3390/md16100344
  8. Antonio Vazquez, Jose; Ramos, Patricia; Valcarcel, Jesus; Antelo, Luis T.; Novoa-Carballal, Ramon; Reis, Rui L.; Perez-Martin, Ricardo, I. "An integral and sustainable valorisation strategy of squid pen by-products". Journal of Cleaner Production 201 (2018): 207-218. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000445981200018&KeyUID=WOS:000445981200018.
    10.1016/j.jclepro.2018.07.316
  9. Novoa-Carballal, Ramon; Carretero, Agatha; Pacheco, Raul; Reis, Rui L.; Pashkuleva, Iva. "Star-Like Glycosaminoglycans with Superior Bioactivity Assemble with Proteins into Microfibers". Chemistry-a European Journal 24 54 (2018): 14341-14345. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000445447400006&KeyUID=WOS:000445447400006.
    10.1002/chem.201802243
  10. Carvalho, A.M.; Teixeira, R.; Novoa-Carballal, R.; Pires, R.A.; Reis, R.L.; Pashkuleva, I.. "Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery". Biomacromolecules 19 7 (2018): 2991-2999. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047094212&partnerID=MN8TOARS.
    10.1021/acs.biomac.8b00561
  11. Novoa-Carballal, R.; Pérez-Martín, R.; Blanco, M.; Sotelo, C.G.; Fassini, D.; Nunes, C.; Coimbra, M.A.; et al. "By-products of Scyliorhinus canicula, Prionace glauca and Raja clavata: A valuable source of predominantly 6S sulfated chondroitin sulfate". Carbohydrate Polymers 157 (2017): 31-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988535422&partnerID=MN8TOARS.
    10.1016/j.carbpol.2016.09.050
  12. Vázquez, J.A.; Noriega, D.; Ramos, P.; Valcarcel, J.; Novoa-Carballal, R.; Pastrana, L.; Reis, R.L.; Pérez-Martín, R.I.. "Optimization of high purity chitin and chitosan production from Illex argentinus pens by a combination of enzymatic and chemical processes". Carbohydrate Polymers 174 (2017): 262-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021140013&partnerID=MN8TOARS.
    10.1016/j.carbpol.2017.06.070
  13. Silva, C.; Carretero, A.; Soares da Costa, D.; Reis, R.L.; Novoa-Carballal, R.; Pashkuleva, I.. "Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors". Acta Biomaterialia 63 (2017): 283-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029607589&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.08.042
  14. Oliveira, C.; Ferreira, A.S.; Novoa-Carballal, R.; Nunes, C.; Pashkuleva, I.; Neves, N.M.; Coimbra, M.A.; et al. "The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity". Macromolecular Bioscience 17 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009179205&partnerID=MN8TOARS.
    10.1002/mabi.201600340
  15. Valcarcel, J.; Novoa-Carballal, R.; Pérez-Martín, R.I.; Reis, R.L.; Vázquez, J.A.. "Glycosaminoglycans from marine sources as therapeutic agents". Biotechnology Advances 35 6 (2017): 711-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025829457&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2017.07.008
  16. Silva, K.N.; Novoa-Carballal, R.; Drechsler, M.; Müller, A.H.E.; Penott-Chang, E.K.; Müller, A.J.. "The influence of concentration and pH on the structure and rheology of cationic surfactant/hydrotrope structured fluids". Colloids and Surfaces A: Physicochemical and Engineering Aspects 489 (2016): 311-321. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946950095&partnerID=MN8TOARS.
    10.1016/j.colsurfa.2015.10.054
  17. Silva, L.P.D.; Pirraco, R.P.; Santos, T.C.; Novoa-Carballal, R.; Cerqueira, M.T.; Reis, R.L.; Correlo, V.M.; Marques, A.P.. "Neovascularization Induced by the Hyaluronic Acid-Based Spongy-Like Hydrogels Degradation Products". ACS Applied Materials and Interfaces 8 49 (2016): 33464-33474. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006256121&partnerID=MN8TOARS.
    10.1021/acsami.6b11684
  18. Pires, Ricardo A.; Abul-Haija, Yousef M.; Costa, Diana S.; Novoa-Carballal, Ramon; Reis, Rui L.; Ulijn, Rein V.; Pashkuleva, Iva. "Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile". Journal of the American Chemical Society 137 2 (2015): 576-579. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348483400007&KeyUID=WOS:000348483400007.
    10.1021/ja5111893
  19. Silva, Carla (6F11-012B-C647); Novoa-Carballal, Ramon; Reis, Rui L.; Pashkuleva, Iva. "Following the enzymatic digestion of chondroitin sulfate by a simple GPC analysis". Analytica Chimica Acta 885 (2015): 207-213. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358697600019&KeyUID=WOS:000358697600019.
    10.1016/j.aca.2015.05.034
  20. Yemisci, Muge; Caban, Secil; Gursoy-Ozdemir, Yasemin; Lule, Sevda; Novoa-Carballal, Ramon; Riguera, Ricardo; Fernandez-Megia, Eduardo; et al. "Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection". Journal of Cerebral Blood Flow and Metabolism 35 3 (2015): 469-475. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000350393600016&KeyUID=WOS:000350393600016.
    10.1038/jcbfm.2014.220
  21. Kozlu S; Caban S; Yerlikaya F; Fernandez-Megia E; Novoa-Carballal R; Riguera R; Yemisci M; et al. "An aquaporin 4 antisense oligonucleotide loaded, brain targeted nanoparticulate system design.". Die Pharmazie 69 5 (2014): 340-345. http://europepmc.org/abstract/med/24855824.
    10.1691/ph.2014.3149
  22. Novoa-Carballal, R.; Silva, C.; Möller, S.; Schnabelrauch, M.; Reis, R.L.; Pashkuleva, I.. "Tunable nano-carriers from clicked glycosaminoglycan block copolymers". Journal of Materials Chemistry B 2 26 (2014): 4177-4184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902241807&partnerID=MN8TOARS.
    10.1039/c4tb00410h
  23. Ozturk, K.; Fernandez-Megia, E.; Novoa-Carballal, R.; Riguera, R.; Yemisci, M.; Gursoy-Ozdemir, Y.; Dalkara, T.; Couvreur, P.; Capan, Y.. "Comparative in vitro studies on PBN loaded nanoparticles prepared by biodegradable chitosan, PLGA polymersand their PEGylated block copolymers". Journal of Drug Delivery Science and Technology 24 2 (2014): 148-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899527016&partnerID=MN8TOARS.
    10.1016/S1773-2247(14)50024-X
  24. Sousa-Herves, A.; Novoa-Carballal, R.; Riguera, R.; Fernandez-Megia, E.. "GATG dendrimers and PEGylated block copolymers: From synthesis to bioapplications". AAPS Journal 16 5 (2014): 948-961. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908356572&partnerID=MN8TOARS.
    10.1208/s12248-014-9642-3
  25. Novoa-Carballal, R.; Riguera, R.; Fernandez-Megia, E.. "Disclosing an NMR-invisible fraction in chitosan and PEGylated copolymers and its role on the determination of degrees of substitution". Molecular Pharmaceutics 10 8 (2013): 3225-3231. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881362806&partnerID=MN8TOARS.
    10.1021/mp400267m
  26. Novoa-Carballal, R.; Pfaff, A.; Müller, A.H.E.. "Interpolyelectrolyte complexes with a polysaccharide corona from dextran-block-PDMAEMA diblock copolymers". Polymer Chemistry 4 7 (2013): 2278-2285. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874923814&partnerID=MN8TOARS.
    10.1039/c3py21088j
  27. Novoa-Carballal, R.; Pergushov, D.V.; Müller, A.H.E.. "Interpolyelectrolyte complexes based on hyaluronic acid-block-poly(ethylene glycol) and poly-l-lysine". Soft Matter 9 16 (2013): 4297-4303. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878066803&partnerID=MN8TOARS.
    10.1039/c3sm27549c
  28. Torrecilla, D.; Lozano, M.V.; Lallana, E.; Neissa, J.I.; Novoa-Carballal, R.; Vidal, A.; Fernandez-Megia, E.; et al. "Anti-tumor efficacy of chitosan-g-poly(ethylene glycol) nanocapsules containing docetaxel: Anti-TMEFF-2 functionalized nanocapsules vs. non-functionalized nanocapsules". European Journal of Pharmaceutics and Biopharmaceutics 83 3 (2013): 330-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875219606&partnerID=MN8TOARS.
    10.1016/j.ejpb.2012.10.017
  29. Novoa-Carballal, R.; Riguera, R.; Fernandez-Megia, E.. "Chitosan hydrophobic domains are favoured at low degree of acetylation and molecular weight". Polymer (United Kingdom) 54 8 (2013): 2081-2087. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875731445&partnerID=MN8TOARS.
    10.1016/j.polymer.2013.02.024
  30. Jakob, F.; Pfaff, A.; Novoa-Carballal, R.; Rübsam, H.; Becker, T.; Vogel, R.F.. "Structural analysis of fructans produced by acetic acid bacteria reveals a relation to hydrocolloid function". Carbohydrate Polymers 92 2 (2013): 1234-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869864953&partnerID=MN8TOARS.
    10.1016/j.carbpol.2012.10.054
  31. Novoa-Carballal, R.; Müller, A.H.E.. "Synthesis of polysaccharide-b-PEG block copolymers by oxime click". Chemical Communications 48 31 (2012): 3781-3783. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860188653&partnerID=MN8TOARS.
    10.1039/c2cc30726j
  32. Novoa-Carballal, R.; Fernandez-Megia, E.; Jimenez, C.; Riguera, R.. "NMR methods for unravelling the spectra of complex mixtures". Natural Product Reports 28 1 (2011): 78-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650489742&partnerID=MN8TOARS.
    10.1039/c005320c
  33. Novoa-Carballal, R.; Fernandez-Megia, E.; Riguera, R.. "Dynamics of chitosan by 1H NMR relaxation". Biomacromolecules 11 8 (2010): 2079-2086. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955561793&partnerID=MN8TOARS.
    10.1021/bm100447f
  34. Ravina, M.; Cubillo, E.; Olmeda, D.; Novoa-Carballal, R.; Fernandez-Megia, E.; Riguera, R.; Sánchez, A.; Cano, A.; Alonso, M.J.. "Hyaluronic acid/chitosan-g-poly(ethylene glycol) nanoparticles for gene therapy: An application for pDNA and siRNA delivery". Pharmaceutical Research 27 12 (2010): 2544-2555. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651345628&partnerID=MN8TOARS.
    10.1007/s11095-010-0263-y
  35. Novoa-Carballal, R.; Säwén, E.; Fernandez-Megia, E.; Correa, J.; Riguera, R.; Widmalm, G.. "The dynamics of GATG glycodendrimers by NMR diffusion and quantitative13C relaxation". Physical Chemistry Chemical Physics 12 25 (2010): 6587-6589. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953838714&partnerID=MN8TOARS.
    10.1039/c003645p
  36. Karatas, H.; Aktas, Y.; Gursoy-Ozdemir, Y.; Bodur, E.; Yemisci, M.; Caban, S.; Vural, A.; et al. "A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection". Journal of Neuroscience 29 44 (2009): 13761-13769. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449441249&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4246-09.2009
  37. Csaba, N.; Köping-Höggård, M.; Fernandez-Megia, E.; Novoa-Carballal, R.; Riguera, R.; Alonso, M.J.. "Ionically crosslinked chitosan nanoparticles as gene delivery systems: Effect of PEGylation degree on in vitro and in vivo gene transfer". Journal of Biomedical Nanotechnology 5 2 (2009): 162-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649366349&partnerID=MN8TOARS.
    10.1166/jbn.2009.1017
  38. Pinarbasli, O.; Aktas, Y.; Dalkara, T.; Andrieux, K.; Alonso, M.J.; Fernandez-Megia, E.; Novoa-Carballal, R.; et al. "Preparation and evaluation of alpha-phenyl-n-tert-butyl nitrone (PBN)-encapsulated chitosan and PEGylated chitosan nanoparticles". Pharmazie 64 7 (2009): 436-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349256078&partnerID=MN8TOARS.
    10.1691/ph.2009.8374
  39. Fernandez-Megia, E.; Novoa-Carballal, R.; Quiñoá, E.; Riguera, R.. "Conjugation of bioactive ligands to PEG-grafted chitosan at the distal end of PEG". Biomacromolecules 8 3 (2007): 833-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947700999&partnerID=MN8TOARS.
    10.1021/bm060889x
  40. Fernandez-Megia, E.; Correa, J.; Novoa-Carballal, R.; Riguera, R.. "Paramagnetic NMR relaxation in polymeric matrixes: Sensitivity enhancement and selective suppression of embedded species (1H and 13C PSR filter)". Journal of the American Chemical Society 129 49 (2007): 15164-15173. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049010536&partnerID=MN8TOARS.
    10.1021/ja0737117
  41. Prego, C.; Torres, D.; Fernandez-Megia, E.; Novoa-Carballal, R.; Quiñoá, E.; Alonso, M.J.. "Chitosan-PEG nanocapsules as new carriers for oral peptide delivery: Effect of chitosan pegylation degree". Journal of Controlled Release 111 3 (2006): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645241398&partnerID=MN8TOARS.
    10.1016/j.jconrel.2005.12.015
  42. Aktas, Y.; Yemisci, M.; Andrieux, K.; Gürsoy, R.N.; Alonso, M.J.; Fernandez-Megia, E.; Novoa-Carballal, R.; et al. "Development and brain delivery of chitosan-PEG nanoparticles fnnctionalized with the monoclonal antibody OX26". Bioconjugate Chemistry 16 6 (2005): 1503-1511. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944494819&partnerID=MN8TOARS.
    10.1021/bc050217o
  43. Fernandez-Megia, E.; Novoa-Carballal, R.; Quiñoá, E.; Riguera, R.. "Optimal routine conditions for the determination of the degree of acetylation of chitosan by1H-NMR". Carbohydrate Polymers 61 2 (2005): 155-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-22544442811&partnerID=MN8TOARS.
    10.1016/j.carbpol.2005.04.006
Livro
  1. Novoa-Carballal, R.; Riguera, R.; Fernandez-Megia, E.. Chitosan Copolymers for Biopharmaceuticals. 2012.
Poster em conferência
  1. Raul Fontelo; Reis, Rui L.; Novoa-Carballal, Ramon; Pashkuleva, Iva. "Biocompatible nanopatterns generated by self-assembly of block copolymers to understand the role of nanotopography in cell adhesion". Trabalho apresentado em FoReCaST Second Workshop, 2019.
  2. Novoa-Carballal, Ramon; Antonio Vazquez, Jose; Carretero Agatha; Jesus Valcarcel; Reis, Rui L.; Pashkuleva, Iva. "Multivalent proteoglycan mimics generated from glycosaminoglycans end-on linked to star and linear polymers". Trabalho apresentado em First Achilles Conference, 2019.
  3. Raul Fontelo; Reis, Rui L.; Novoa-Carballal, Ramon; Pashkuleva, Iva. "Selective block copolymer films with antibacterial and biocompatible properties". Trabalho apresentado em 13th International Conference on Frontiers in Biomedical Polymers, 2019.
  4. Reis, Rui L.; Raul Fontelo; Novoa-Carballal, Ramon; Pashkuleva, Iva. "Selective toxicity of block copolymers nanopatterns to bacterial versus mammalian cells". Trabalho apresentado em 6th International Conference on Multifunctional, Hybrid and Nanomaterials, 2019.
  5. Novoa-Carballal, Ramon; Marisa Gomes; Carretero, Agatha; Valcarcel, Jesus; Antonio Vazquez, Jose; Reis, Rui L.; Pashkuleva, Iva. "Multivalent proteoglycan mimics generated by end-on oxime ligation". Trabalho apresentado em Chem2nature final Conference, 2018.
    10.2118/3227-ms
  6. Raul Fontelo; Novoa-Carballal, Ramon; Diana Soares da Costa; Reis, Rui, L.; Paskuleva, Iva. "Selective toxicity of block copolymers nanopatterns to bacterial versus mammalian cells". Trabalho apresentado em Chem2nature final Conference, 2018.
  7. Jesus Valcarcel; Novoa-Carballal, Ramon; José A. Vázquez; Gomes, Marisa; Reis, Rui L.; Pashkuleva, Iva. "Synthesis of proteoglycan mimetic copolymers of hydroxyethyl methacrylate and glycosaminoglycans". Trabalho apresentado em 7th EuCheMS Chemistry Congress, 2018.
  8. Novoa-Carballal, Ramon; Gonzalez, Africa; Lozano Tamara; Marisa Gomes; Jesus Valcarcel; Jose Antonio Vazquez; Reis, Rui L.; Pashkuleva, Iva. "Synthesis and anticoagulant activity of star and brush-like glycosaminoglycan copolymers". Trabalho apresentado em TERM STEM Forecast, 2017.
  9. Soares da Costa, Diana; Carretero, Agatha; Novoa-Carballal, Ramon; Silva, Carla (6F11-012B-C647); Reis, Rui, L.; Pashkuleva, Iva. "Diblock, tree- and brush-like glycosaminoglycan copolymers with preserved bioactivity by end-on oxime ligation". Trabalho apresentado em International Symposium of Biospired Macromolecular Systems, 2017.
  10. Novoa-Carballal, Ramon; Alexandra Brito; Abul-Haija, Yousef M.; Uljin, R.V.; Diana Soares da Costa; Pires, Ricardo A.; Reis, Rui L.; Pashkuleva, Iva. "Supramolecular hydrogels based on the co-assembly of simple carbohydrates and peptide amphiphiles for biological applications". Trabalho apresentado em 12ª Reunião do Grupo de Glúcidos – Glupor12, 2017.
  11. Carretero, Agatha; Novoa-Carballal, Ramon; Silva, Carla; Diana Soares da Costa; Reis, Rui, L.; Paskuleva, Iva. "Glycosaminoglycan copolymers with preserved bioactivity by end-on oxime ligation". Trabalho apresentado em Frontiers in Polymer Science, 2017.
  12. Silva, Lucilia; Pirraco, R. P.; Novoa-Carballal, Ramon; Cerqueira, M.T; Reis, R.L.; Marques, A.P.. "Hyaluronidase mediated degradation products of hyaluronic acid based spongylike hydrogels promote neovascularization". Trabalho apresentado em Chem2nature first School, 2016.
  13. Novoa-Carballal, Ramon; Carretero, Agatha; Raquel, Teixeira; Soares da Costa, Diana; Pashkuleva, Iva; Silva, Carla; Reis, Rui L.. "Glycosaminoglycan copolymers with preserved bioactivity by Oxime Click: application as GFs delivery systems, PG mimic fibers gels and surfaces". Trabalho apresentado em Chem2nature first School, 2016.
  14. Novoa-Carballal, Ramon; Carretero, Agatha; Silva,Carla; Reis, Rui L.; Pashkuleva, Iva. "Expanding the Glycopolymer Family by Oxime Coupling: Synthesis and interpolyelectrolyte complexation of tree and brush-like glycopolymers with long glycan branches". Trabalho apresentado em 5th Portuguese Young Chemists Meeting (5th PYCheM)/ 1st European Young Chemists Meeting, 2016.
  15. Novoa-Carballal, Ramon; Silva, Carla; Reis, Rui, L.; Pashkuleva, Iva. "Biomimetic encapsulation of FGF-2 into PEGylated nanocarriers". Trabalho apresentado em Polaris Conference, 2015.
  16. Novoa-Carballal, Ramon; Sousa, Ana; Calderon, Marcelo; Resi, Rui L.; Pashkuleva, Iva. "Oxime Click Chemistry to MImic the complexity of natural Glycosamino Glycnas: Three and brush-like structures". Trabalho apresentado em Multivalency in chemistry and biochemistry, 2014.
  17. Novoa-Carballal, Ramon; Silva, Carla; Rui, L. Reis; Pashkuleva, Iva. "Real-time analysis of the enzymatic digestion of chondroitin sulfate: role of the sulfation pattern". Trabalho apresentado em ESB 2014, 2014.

Propriedade Intelectual

Patente
  1. Novoa-Carballal, Ramon. 2018. "HIGH MOLECULAR WEIGHT CHITOSAN, PROCESS FOR OBTAINING AND USES THEREOF".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/03/15 Multivalent proteoglycan mimics generated by glycosaminoglycan end-on oxime ligation 6th International Conference on Multifunctional, Hybrid and Nanomaterials
Elsevier (Sitges, Espanha)
2015/10/20 MIMICKING GAGS ARCHITECTURE IN THE ECM BY OXIME LIGATION: FGF-NANOCARRIERS, PROTEOGLYCAN LIKE COPOLYMERS AND GAG NANOARRAYS Polaris
Universidade do Minho (Porto, Portugal)
2014/08/31 Protein nano-carriers from clicked glycosaminoglycan block copolymers ESB 2014
European Society of Biomaterials (Liverpool, Reino Unido)
2014/08/31 Real-time analysis of the enzymatic digestion of chondroitin sulfate: role of the sulfation pattern ESB 2014
European Society of Biomaterials (Liverpool, Reino Unido)
2014/01/24 MIMICKING THE COMPLEXITY OF NATURAL POLYSACCHARIDES BY OXIME CLICK CHEMISTRY: TREE-LIKE GLYCOSAMINOGLYCANS EDEN (encuentro de dendrimeros)
Universidad de Santiago de Compostela (Santiago de Compostela, Espanha)
2012/07/09 Synthesis of Polysaccharide-b-PEG Block Copolymers by Oxime Click and their use for the formation of interpolyelectrolyte nanogels Macrogroup UK, International Conference on Polymer Synthesis
Royal Society of Chemistry (Warwick, Reino Unido)
2008/05/26 CHITOSAN-PEG / HYALURONAN NANOPARTICLES AS NANOCARRIERS FOR GENE DELIVERY 7th Int. Symp. on Polymer Therapeutics
Centro de investigacios principe Felipe (Valencia, Espanha)
2007/03/12 Polymeric Nanostructures for Biomedical Applications: Clickable Dendritic Polymers and PEG-grafted 4th NanoSpain Workshop.
2007/02/09 Aplicación de la RMN a Sistemas Poliméricos de Interés Biomédico Simposium Resonancia Magnética 2007
Universidad de Santiago de Compostela (Santiago de Compostela, Espanha)
2006/10/15 Studying the compactness and aggregation of dendritic polymers and polysaccharides by NMR relaxation times III Reunión Bienal del Grupo Especializado de RMN de la RSEQ
real Sociedad Española de Química (St. Joan, Espanha)
2006/09/06 Aggregation and synthetic studies on chitosan and PEG-grafted chitosan 10th International Conference on Chitin & Chitosan - 7th International
European Chitin Society (Montpellier, França)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2016 - 2016 5th Portuguese Young Chemists Meeting (5th PYCheM)/ 1st European Young Chemists Meeting (2016/04/26 - 2016/04/29)
Conferência (Membro da Comissão Organizadora)
Universidade do Minho, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2019/12/20 Chiral to chiral communication in Polymers: A unique approach to Control both Helical Sense and Chirality at the periphery
Arguente
Kathering Cobos (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2019/12/19 Poly(phenylacetylene) amines: A general route to water soluble helical polyamines
Arguente
Esteban Suarez Picazo (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2018/01/28 Stimuli responsive Materials Based on Helical Polymers
Arguente
Mohammad Alzubi (Doutoramento)
Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha
2017/12/14 Chiral Nanostructure Based on Helical Polymers
Arguente
Sandra Arias (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2015/12/03 Helical sense and Aggregation control of polyphenylacetylenes
Arguente
Seila Leiras (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2014/05/02 Ionic complexes of biodegradable polyelectrolytes
Arguente
Ainhoa Tolentino (Doutoramento)
Universitat Politècnica de Catalunya, Espanha

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2017/01/17 - 2019/12/11 Carbohydrate Polymers (0144-8617) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016/07/31 - 2019/07/31 Polymer Characterization Doctoral Program in Tissue engeneering and regenerative medicine (Doutoramento) Universidade do Minho, Portugal
2018/06/15 - 2018/06/15 Bionanosistemas Para aplicaçoes farmaceuticas e cosmeticas (Mestrado) Universidade do Minho, Portugal
2018/05/30 - 2018/05/30 Introduccion al analisis de Biomateriales (Master) Universidade de Vigo - Campus Lagoas Marcosende, Espanha
2011/06/30 - 2012/06/30 Practical macromolecular Chemistry Chemical Engeneering (Bachelor) Universität Bayreuth, Alemanha
2006/04/04 - 2009/04/04 Quimica Orgánica Experimental (Bachelor) Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha

Tutoria

Tópico Nome do aluno
2016/10/01 - Atual Distinct glycan nanopatterns for studying carbohydrate-protein interactions and their implications in different cellular processes Raul Fontelo
Distinções

Outra distinção

2003 Capsugel Graduate/Postdoc Award Innovate aspects of Gastrointestinal Drug Absorption and Delivery