Rui Miguel Oliveira da Costa (8D18-658D-0961)

Curriculum Vitae

Rui Miguel Oliveira da Costa

Rui Miguel Oliveira da Costa (RC) graduated in Biology in 2006 and earned a PhD in Cell Biology with highest honors in 2011 from the University of Coimbra, Faculty of Science and Technology. RC is currently a Contracted Researcher at the Centro de Inovação em Biomedicina e Biotecnologia (CIBB), where he leads a subgroup within the Neurotrophic Signaling group. Over the last five years, RC has secured research funding, participated in multiple funded projects, and presented his work at national and international meetings. RC has published 18 journal articles (8 as first or senior author, including in high-ranking journals such as Cell Reports, WIREs RNA, Aging Cell, and Neurobiology of Aging) and contributed to 2 book chapters, with 3 additional manuscripts currently under review. His work has garnered 1,576 citations (786 since 2019) and he holds an h-index of 18 (source: Web of Science, Google Scholar). His research focuses on Medical and Health Sciences with an emphasis on Neuroscience, Cell Biology, and synaptic biology. RC has extensive experience in research leadership, serving as Principal Investigator for 2 projects and as a contributor to 14 others in various capacities (e.g., Researcher, Postdoctoral Fellow, Technician). He has collaborated with over 200 researchers, both nationally and internationally, and worked at leading laboratories in Portugal, the USA, and Italy, including advanced training at Northwestern University’s Klein Lab (a leader in Alzheimer’s research) and L. Cancedda’s lab in Italy. His methodological expertise spans microscopy, molecular biology, neuronal cultures, in vivo models, and human sample processing, among others. In academia, RC has formally supervised 1 PhD student (ongoing), 7 MSc theses (4 ongoing) and co-supervised 4. mentored over 14 other MSc and PhD students during their laboratory internships. He has served on committees for 8 MSc thesis defenses and lectured in BSc, MSc, and PhD programs at the Universities of Coimbra and Algarve. RC has organized 5 events, including scientific courses, and participated in 35 conferences. He is also an ad hoc reviewer for several journals, including Aging Cell. RC’s academic and professional excellence has been recognized with 8 awards, including a Scientific Incentive Grant (2022) and competitive FCT fellowships for his PhD and postdoctoral research. Additionally, he has completed advanced training in Laboratory Animal Science (FELASA Category C, 2010). Key research themes in RC’s work include Alzheimer’s disease, ER stress, mitochondria, axonal biology, synaptic biology, and neurodegenerative disorders. His Ciência Vitae profile highlights frequent topics such as neuronal development, axonal degeneration, ribosomes, ubiquitin protein systems, advanced therapies, and biotechnology. RC has also benefited from paternity leave in 2017 and 2023, reflecting a commitment to both professional and personal responsibilities.

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Identificação

Identificação pessoal

Nome completo: Rui Miguel Oliveira da Costa
Data de nascimento: 1983/06/17
Género: Masculino

Nomes de citação

Costa RO
Rui O Costa
Costa, Rui

Identificadores de autor

Ciência ID: 8D18-658D-0961
ORCID iD: 0000-0002-2652-7500
Google Scholar ID: gJoLzOwAAAAJ
Researcher Id: K-6898-2013
Scopus Author Id: 36486010000

Endereços de correio eletrónico

ruiocosta@gmail.com (Profissional)
rui.costa@cnc.uc.pt (Profissional)

Telefones

Telefone

(+351) 239820190 (Profissional)
(+351) 304502914 (Profissional)

Telemóvel

(+351) 965138876 (Pessoal)

Moradas

Centro de NeuroCiências e Biologia Celular. Rua Larga, Faculdade de Medicina, Polo I, 2ºpiso, Lab 206a, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)
Rua Do Brasil Nº351 2ºDir, 3030-175, Coimbra, Coimbra, Portugal (Pessoal)

Websites

http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110#34 (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Italiano	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador elementar (A1)	Utilizador proficiente (C1)	Utilizador independente (B2)
Francês	Utilizador independente (B1)	Utilizador independente (B2)	Utilizador elementar (A1)	Utilizador independente (B2)	Utilizador elementar (A2)
Japonês	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)
Espanhol; Castelhano	Utilizador elementar (A1)	Utilizador independente (B2)	Utilizador elementar (A1)	Utilizador independente (B2)	Utilizador elementar (A2)

Formação

	Grau	Classificação
2016/06/17 - 2016/06/24 Concluído	Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016” (Outros) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006/10/01 - 2011/12/06 Concluído	Doutoramento em Biologia - especialidade em Biologia Celular (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors" (TESE/DISSERTAÇÃO)	Aprovado com Distinção e Louvor, por Unanimidade.
2010/04/19 - 2010/04/30 Concluído	Course on Laboratorial Animal Science (LAS) course - FELASA cat C (Pós-Graduação) CNC.IBILI, Portugal	Approved
2001/09 - 2006/07/05 Concluído	Biologia (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide " (TESE/DISSERTAÇÃO)	15/20 (15.4 valores)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/02/05 - Atual	Investigador Contratado (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/01/01 - 2019/02/04	Pós-doutorado (Investigação)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2015/09 - 2016/01	Investigador visitante (Investigação)	Istituto Italiano di Tecnologia, Itália
	Istituto Italiano di Tecnologia, Itália
2006/10/01 - 2011/12/06	Investigador (Investigação)	CNC.IBILI, Portugal
	CNC.IBILI, Portugal
2008/06 - 2009/03	Investigador visitante (Investigação)	Northwestern University - Chicago, Estados Unidos
	Northwestern University - Chicago, Estados Unidos

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2011/01 - 2011/09	Research Technician	CNC.IBILI, Portugal

Projetos

Bolsa

	Designação	Financiadores
2021/07/01 - Atual	Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization PTDC/BIA-CEL/2286/2020 Investigador	Fundação para a Ciência e a Tecnologia
2019/02/05 - Atual	BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke. PTDC/CTM-NAN/3547/2014. Investigador
2019 - Atual	Strategic Plan CNC.IBILI UID/ NEU/04539/2019 Investigador Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia
2022 - 2023	The RNA-binding protein hnRNPH2: a novel player in epileptogenesis n.a Investigador responsável Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Em curso
2013/01/01 - 2019/02	Pos-Doc project: Mechanisms underlying ribosomal regulation in axonal development SFRH/BPD/84593/2012 Bolseiro de Pós-Doutoramento CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/07 - 2014/12	Mechanism underlying ribosomal regulation in axonal development grant.Provided by PTCRIS: 126236 EXPL/NEU-NMC/0541/2012 Investigador responsável Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/06 - 2013/06	In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging grant.Provided by PTCRIS: 103538 Investigador Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2011/09/30	The role of mRNA translation in the formation of the neuromuscular junction. PTDC/SAU-NEU/104100/2008 Bolseiro de Técnico de Investigação Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008 - 2010	Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools PIC/IC/83206/2007 Investigador	Fundação para a Ciência e a Tecnologia
2008 - 2010	Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease PTDC/SAU-NEU/71675/2006 Investigador	Fundação para a Ciência e a Tecnologia
2006 - 2010	PhD project: Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors SFRH/BD/28403/2006 Bolseiro de Doutoramento CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015 - 2018	Funding of RD Units Strategic Plan - 2013/2015 - OE UID/NEU/04539/2013 Investigador Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013 - 2014	Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE PEst-C/SAU/LA0001/2013 Investigador Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/06/01 - 2013/06/30	Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento PTDC/SAU-NEU/103538/2008 Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/03 - 2011/02	Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine n/a Investigador	Lundbeck foundation (portuguese office)

Outro

	Designação	Financiadores
2005 - 2006	Cross-talk between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids n/a Investigador Center for Neurosciences and Cell Biology, University of Coimbra, Portugal	L’Oréal Portugal/UNESCO/FCT Concluído

Produções

Publicações

Artigo em conferência	Ferreira I.L.; Mota S.I.; Costa RO; Padovano C.; Fonseca A.C.; Letra L.; Oliveira C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em AD/PD 2011, Barcelona, 2011. Publicado Costa RO; P.N. Lacor; I.L. Ferreira; A.C. Rego; W.L. Klein; C. Pereira. "Role of N-Methyl-D- Aspartate receptors in endoplasmic reticulum stress induced by amyloide peptide oligomers". Trabalho apresentado em AD/PD 2009, Prague, 2009. Publicado Elisabete Ferreiro; Rosa Resende; Costa RO; P Moreira; Sandra Cardoso; Cláudia Pereira; CR Oliveira. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Trabalho apresentado em European Meeting of the Society-for-Free-Radical-Research-Europe, 2007. Publicado
Artigo em revista	Rui O. Costa; Luís F. Martins; Emanuel Tahiri; Carlos B. Duarte. "Brain-derived neurotrophic factor -induced regulation of RNA metabolism in neuronal development and synaptic plasticity". WIREs RNA (2022): https://doi.org/10.1002/wrna.1713. 10.1002/wrna.1713 Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D.. "Isolation and Culture of Chick Ciliary Ganglion Neurons". Journal of Visualized Experiments 162 (2020): http://dx.doi.org/10.3791/61431. 10.3791/61431 Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080. 10.1016/j.celrep.2019.06.080 Mele, Miranda; Costa, Rui O.; Duarte, Carlos B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00077. 10.3389/fncel.2019.00077 Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos; Costa RO. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551. 10.21769/bioprotoc.2551 Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS. 10.1038/s41598-017-03592-1 Costa, R.O.; Perestrelo, T.; Almeida, R.D.. "PROneurotrophins and CONSequences". Molecular Neurobiology (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS. 10.1007/s12035-017-0505-7 Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017. 10.1523/ENEURO.0268-17.2017 Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D.. "Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)". Frontiers in Molecular Neuroscience 9 JUNE (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS. 10.3389/fnmol.2016.00043 Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS. 10.1016/j.bbadis.2015.03.015 Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS. 10.1016/j.neuroscience.2013.02.062 Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS. 10.1016/j.mcn.2012.09.005 Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS. 10.1155/2012/735206 Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2011.04.011 Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS. 10.1111/j.1474-9726.2012.00848.x Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS. 10.3233/JAD-2010-091369 Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS. 10.1111/j.1471-4159.2007.05048.x Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS. 10.1016/j.nbd.2006.05.011
Capítulo de livro	Costa, Rui O.; Perestrelo, Tânia; Tomé, Diogo; Almeida, Ramiro D.. "A Microfluidic Culture Platform for Neurotrophin Signaling Studies". In Brain-Derived Neurotrophic Factor (BDNF), 185-201. Springer New York, 2018. Publicado • 10.1007/7657_2018_9 Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, Estados Unidos: Nova Science Publishers, Inc.,, 2008. Publicado
Manual	Santos-Carvalho, Ana; Rui O Costa; Maria Inês Morte; Pedro Alves. Fisiologia Celular e Biologia Molecular. Portugal. 2013.
Poster em conferência	Silva, Marta; Duarte, Carlos B.; Costa, Rui. "The RNA-binding protein hnRNP H2: a novel player in neurodevelopmental disorders and epileptogenesis". Trabalho apresentado em iMed Conference 15.0, 2023. Tahiri, Emanuel; Alexandra Filipa almeida Santos; Marta Sofia Santos Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Autor correspondente: Costa, Rui. "Intra-axonal autophagosome biogenesis impairment in Alzheimer’s disease". Trabalho apresentado em ISN-ESN 2023 Porto, Portugal, 2023. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Autor correspondente: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Trabalho apresentado em BEB DAY 2023 in Coimbra on the days 7th and 8th of February (https://cnc.uc.pt/en/pdbeb/beb-news/beb-day-2023-1), 2023. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Autor correspondente: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Trabalho apresentado em 2nd symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics (https://www.adconferences.com/), 2023. Claudia Corso; Giorgio Belperio; Cinzia Miarelli; Rodrigues, Catarina; Filipe Duarte; Costa, Rui; Duarte, Carlos B.; Mele, Miranda. "K+-Cl- cotransporter (KCC2) activation as a novel therapeutic strategy for epilepsy". Trabalho apresentado em 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra, 2022. Tomé D; Martins LF; Costa RO; Serra SC; Duarte CB; Pinheiro PS; Salgado AJ; Almeida RD. "Regenerative and synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Trabalho apresentado em VIII European Synapse Meeting (Coimbra, Portugal), 2022. Tahiri, Emanuel; Alexandra Santos; Duarte, Carlos B.; Costa RO. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction: an early event in Alzheimers disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021 #NNR-71, 2021. Costa RO; Tomé, Diogo; Martins, Luís; Lia G Carvalhais; Sofia C Serra; Paulo S Pinheiro; Duarte, Carlos B.; Antonio J Salgado; Almeida, Ramiro D. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021. Guilherme G Trigo; Joana R Pedro; Diogo Tomé; Costa RO; Ramiro D Almeida. "Intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". 2021. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021. Tomé D; Martins LF; Carvalhais LG; Costa RO; Serra SC; Pinheiro PS; Duarte CB; Salgado AJ; Almeida RD. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (Coimbra, Portugal), 2021. Costa RO; Tahiri, Emanuel; Marta Silva; Duarte, Carlos B.. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction in Alzheimer’s disease". Trabalho apresentado em EMBO Workshop Axons 2021; structure and function, 2021. Miranda Mele; Cinzia Miarelli; Giorgio Belperio; Giovanna Lombardi; Filipe Valente Duarte; Costa RO; Carlos B. Duarte. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Trabalho apresentado em Congresso Virtual da LPCE - 33º eENE, 2021. Diogo Tomé; Luís F. Martins; Costa RO; Sofia C. Serra, Nuno Sousa, António J. Salgado & Ramiro D. Almeida. "Mesenchymal stem cells secretome induces synapse formation in central nervous system neurons.". Trabalho apresentado em Secretive With]Out[ Borders meeting, Braga, Portugal, 6- 7th December, 2018., 2018. Costa RO; Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "Mechanisms underlying ribosomal regulation in axonal development". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016., 2016. Luís F. Martins; Costa RO; Susana Sampaio, Joana Pedro, Sofia Serra, Nuno Sousa, António Salgado, Ramiro Almeida. "Mesenchymal stromal cells secretome-induced axonal outgrowth is mediated by BDNF". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016. Joana Pedro; Maria Joana Pinto; Costa RO; Pedro Alves, Hyun Ryu, Noo Li Jeon Samie Jaffrey & Ramiro Almeida. "Presynaptic differentiation triggered by target-derived cue is mediated by local protein synthesis". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016. Costa RO; Joana R. Pedro, Maria Joana Pinto, Hyun R. Ryu, Noo Li Jeon, Samie R. Jaffrey & Ramiro D. Almeida. "Intra-axonal translation is required for synapse formation". Trabalho apresentado em SFN 2014 meeting, Washington DC, USA, November 15th-19th, 2014, 2014. Joana R. Pedro; Maria Joana Pinto; Costa RO; Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "Intra-axonal translation of ß-actin is required for presynaptogenesis". Trabalho apresentado em 4th European synapse meeting, Bordeux, France August 28th-30th, 2013, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, Milan, Italy, July 5th-9th, 2013, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto; Hyunryul Ryu; Noo Li Jeon; Samie Jaffrey; Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, 2013. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em CNC meeting, Biocant, Cantanhede, December 19th-20th, 2012, 2012. Mota, S.I.; Costa RO; Caldeira G.L., Santana I., Padovano C., Fonseca A.C., Letra L., Oliveira C., Ferreira I.L., Perei. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Trabalho apresentado em Neurodegenerative Diseases Meeting, Cold Spring Harbor, New York, USA, Nov 28th-Dec 1st, 2012. equal contibution, 2012. Fonseca A.C.; Ferreira I.L.; Costa RO; Mota S.I., Padovano C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Trabalho apresentado em Sinal, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, April 29th-30st, 2011, 2011. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C., Fonseca A.C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em 10th International Conference AD/PD, Barcelona, Spain, March 9th-13th, 2011, 2011. Martins I.; Gomes S.; Costa RO; Martins I., Gomes S., Costa R.O., Resende R., Oliveira C.R., Pereira C.M.. "Effect of leptin and ghrelin in hippocampal neurons against Alzheimer ´s disease neurotoxins – amyloid-beta peptide". Trabalho apresentado em XVII National Congress of Biochemistry, Oporto, Portugal, December 15th-17th, 2010, 2010. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M.. "Ghrelin and leptin protect hippocampal neurons and hypothalamic cells against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer ´s disease.". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, November 28th-30th 2010, 2010. Costa RO; Lacor P.N., Klein W.L., Rego A.C. and Pereira C.. "Alzheimer’s disease-associated amyloid-peptide oligomers induce endoplasmic reticulum stress through N-methyl-D- aspartate receptors in hippocampal neurons.". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Neatherlands, July 3rd-7th, 2010, 2010. Elisabete Ferreiro; Costa RO; Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudia Pereira.. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Netherlands, July 3rd-7th, 2010, 2010. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M. "Leptin and Ghrelin protect against Aß-induced toxicity in hippocampal and hypothalamic neurons". Trabalho apresentado em Final Annual Network Meeting, ENINET, Coimbra, Portugal, May 6th-8th, 2010, 2010. Oliveira C.R.,; Ferreira I.L.; Costa RO; Mota S.I., Bajouco M., Lacor P.N., Klein W.L., Rego A.C., Pereira C.. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Trabalho apresentado em 39th Annual Meeting of the American Society for Neuroscience (SFN). Chicago, USA, October 17th-21th, 2009., 2009. Costa RO; Ferreira IL, Rego AC, Klein WL, Pereira C.. "Role of N-methyl-D-aspartate receptors in endoplasmic reticulum stress induced by Aß oligomers". Trabalho apresentado em 9th Internacional Conferente on Alzheimer’s and Parkinson’s Diseases (AD/PD), Prague, Czech Republic. March 11th -15th, 2009, 2009. Elisabete Ferreiro; Costa RO; Rosa Resende, Sueli Marques, Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudi. "Communication between endoplasmic reticulum and mitochondria in neuronal death induced by amyloid-beta peptide.". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, Hungary, November 8th-11th, 2008, 2008. Pereira C.,; Ferreiro E.; Costa RO; Resende R., Cardoso S., Oliveira C.R. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer’s disease- associated beta-amyloid peptide". Trabalho apresentado em 11th International Conference on Alzheimer’s Disease and Related Disorders. Chicago, USA, 26th-31st July, 2008, 2008. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira e Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition.". Trabalho apresentado em 6th FENS, Forum of European Neuroscience, Geneva, Switzerland. June 12th-16th, 2008, 2008. Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sueli Marques; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Trabalho apresentado em Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira, Cláudia Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to Alzheimer´s disease". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal, May 25th, 2007, 2007. Elisabete Ferreiro; Costa RO; Catarina R. Oliveira, Cláudia Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on Alzheimer’s disease cybrids.". Trabalho apresentado em 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Salzburg, Austria, March 15th-18th, 2007, 2007. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006. Ana Gouveia; Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "“Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer.". Trabalho apresentado em V Congresso de Investigação em Medicina, Coimbra, Portugal. November 23rd-24th, 2006., 2006. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira e Cláudia Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Trabalho apresentado em 10th International Conference on Alzheimer’s disease and related disorders, Madrid, Spain, July 15th-20th, 2006*, 2006.
Pré-impressão	Pasqualino De Luca; Miranda Mele; Sara Tanqueiro; Francesca Napoli; Ugné Butkeviciute; Arthur C. Souto; Rui O. Costa; et al. "Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in epileptogenesis". 2024. https://doi.org/10.1101/2024.10.21.618702. 10.1101/2024.10.21.618702 Salazar, Ivan L.; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; Costa, Rui O.; Caldeira, Margarida V.; Trader, Darci J; Duarte, Carlos B.. "Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons". 2024. http://dx.doi.org/10.1101/2024.05.15.594129. 10.1101/2024.05.15.594129 1. Diogo Tomé; Luís F. Martins; Miguel Aroso; Costa RO; Sofia C. Serra; Paulo Aguiar; Carlos B. Duarte; et al. "Mesenchymal stem cells secretome-induced synaptogenesis is mediated by Thrombospondin-1". 2024.
Resumo em conferência	Costa RO; Lacor, P.N.; Klein, W.L.; Rego AC; Cláudia Pereira. "Alzheimers disease-associated amyloide peptide oligomers induce endoplasmic reticulum stress throught N-Methyl-D- Aspartate receptors in hippocampal neurons". Trabalho apresentado em Federation of European Neuroscience Societies (2010), Amsterdam, 2010. Publicado Ferreiro, E.; Rui O Costa; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C.R.; Pereira, C.. "10.1016/j.jns.2009.02.158 Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, 2009. Publicado • 10.1016/j.jns.2009.02.158 Pereira, Cláudia M.F.; Ferreiro, Elisabete B.; Rui O Costa; Resende, Rosa M.M.B.; Cardoso, Sandra M.; Oliveira, Catarina R.. "10.1016/j.jalz.2008.05.1011 P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide". Trabalho apresentado em 11ª International conference on Alzheimer's Disease and Reletaded Disorders, Chicago, 2008. Publicado • 10.1016/j.jalz.2008.05.1011 Costa RO; Elisabete Ferreiro; CR Oliveira; Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition". Trabalho apresentado em Federation of European Neuroscience Societies (FENS), Geneva, 2008. Publicado Costa RO; Elisabete Ferreiro; Catarina Resende de oliveira; Claudia pereira. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". Trabalho apresentado em 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry, 2007. Publicado
Tese / Dissertação	Pereira, Cláudia Maria Fragão; Palmeira, Carlos. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". Doutoramento, 2011. http://hdl.handle.net/10316/18243.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2022/06	Amyloid-ß oligomers impair intra-axonal autophagy	GEECD 2022 (Portugal)
2022/06	The role of intra-axonal autophagy in Alzheimer’s disease	GEECD 2022 (Portugal)
2022/04/23	Da ideia à publicação dos resultados: Como se faz (neuro)ciência?	MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/) Meet.LAB (Coimbra, Portugal)
2020/06/03	Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons	Portuguese Postdoc exchange program Instituto Gulbenkian de Ciência (ICG) - Portugal (WEBINAR, Portugal)
2017/02	Axonal regulation of ribosome content during development	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02	Local application of MSCs secretome induces axonal elongation in CNS neurons	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2013/06	Oxidative and ER stress in early stages of Alzheimer’s disease	13a Reunião da Sociedade Portuguesa de Neurociências Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04	Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease	Oxidative Stress & Disease -The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease Gordon Conference Gordon Conference (Les Diablerets, Suiça)
2013/03/23	Alzheimer’s Disease: Biochemical Approaches to Molecular Mechanisms	VI Encontro Nacional de Estudantes de Bioquímica VI Encontro Nacional de Estudantes de Bioquímica (Aveiro, Portugal)
2012/06	Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease	26a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2012/03/17	Percurso académico e ciêntifico. O nosso actual trabalho laboratorial.	Simpósio:Jovens cientistas no IEC Instituto de Educação e Cidadania (IEC) (Mamarrosa, Oliveira do bairro, Portugal)
2010/06	Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06	Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer’s disease	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06	Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2009/06	Endoplasmic reticulum stress in hippocampal neurons induced by Alzheimer’s disease-Associated amyloid-beta oligomers. Role of NR2A and NR2B subunits of N-Methyl-D-ASpartate (NMDA) receptor	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06	O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na doença de Alzheimer	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2007/06	Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2006/12	Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides.	XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/06	Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2024/09/01 - Atual	RNA-binding protein hnRNPH2: The role of RRM2 mutations in neuronal development and function Orientador	master in molecular and translational neuroscience (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2024/09/01 - Atual	RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function Orientador de Afonso Lourinho	Master's Thesis in Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2024/03 - Atual	Study the role of ATG16 in intra-axonal autophagy in Alzheimer’s disease. Orientador	Corso di Laurea Magistrale in Biologia. Tesi di Laurea Magistrale in Basi farmacologiche della terapia. (Mestrado) Università degli Studi del Sannio, Itália
2024/03 - Atual	The Role of HNRNP H2 mutations in Epileptogenesis. Orientador de Marco D'Ambrosio	Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Mestrado) Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Itália
2022/10 - Atual	Autophagy dysfunction in axons: new evidence for Alzheimer´s disease pathogenesis UI/BD/154202/2022 Orientador de Emanuel Tahiri	Doutoramento em neurociências - Experimental Biology and Biomedicine (BEB) (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra, Portugal
2022/09/01 - 2023/09/18	The RNA-binding protein hnRNPH2: a novel player in epileptogenesis Orientador de Marta Sofia Santos Silva	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2022/03/01 - 2023/02/24	The role of heterogeneous ribonuclear proteins in Epilepsy and autism spectrum disorders. Orientador de Giovanna Di Pietro	Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari Università degli Studi del Sannio, Itália Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/10 - 2022/09	Autophagosome biogenesis and axonal transport dysfunction in Alzheimer’s disease Orientador de Alexandra Filipa Almeida Santos	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2021/09 - 2022/09	The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2 Coorientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/09/10 - 2021/12/13	Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation Coorientador de Guilherme Gomes Trigo	Biomedicina Molecular (Mestrado) Universidade de Aveiro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/10 - 2021/10/01	Early autophagy dysfunction in Alzheimer’s Disease: the role of WIPI2 Orientador de Emanuel Tahiri	Biologia Celular e Molecular (Mestrado) Università degli Studi del Sannio, Itália Universidade de Coimbra, Portugal
2020/03/01 - 2021/02/24	Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development. Coorientador de Giorgio Belperio	Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Mestrado) Università degli Studi di Napoli Federico II, Itália Università degli Studi del Sannio, Itália Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014/09/08	Modulation of synaptic mRNA composition Coorientador de Helena Sofia Caria Martins	Modulation of synaptic mRNA composition (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023 - Atual	"Un viaggio nei meccanismi della memoria" (https://www.futuroremoto.eu/programma-completo-futuro-remoto-2023-online/) as part of the XXXVII edition of "Futuro Remoto," (https://www.futuroremoto.eu/archivio-%c2%b7-programma-edizione-2023-%c2%b7-napoli/) a science dissemination event held both in-person at Città della Scienza, Naples (Italy), and remotely. The Futuro Remoto event in 2023 received recognition from the President of the Italian Republic. (2023)
2023 - Atual	“Meet My Science” (2023–present), a seminar series initiated by PostDoc representatives at CIBB to spotlight ongoing research. (2023) Seminário (Coorganizador)
2021/11/19 - Atual	Seminar: Amyloid beta oligomers in neurodegeneration and neurodevelopment. Professor William Klein, Department of Neurobiology, Weinberg College o Arts & Sciences, Northwestern University, USA Friday, November 19, 2021, 3 pm @ Zoom Meeting Host: Rui O. Costa, CNC www.cnc.uc.pt/pt/seminars (2021/11/19) Seminário (Coorganizador)	Universidade de Coimbra, Portugal
2019 - 2022	“CNC Weekly Seminars” (2019–2022), fostering regular scientific discussions within the community. (2019 - 2023) Seminário (Coorganizador)
2012 - 2014	Co-organizer of the Cell Physiology and Molecular Biology course lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)” (4 courses of 10 classes, 3 hours each. Total = 120 hours). Co-author of protocol manual book used in Cell Physiology and Molecular Biology courses lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)”. (2012 - 2014) Outro (Coorganizador)	Instituto de Educação e Cidadania, Portugal

Participação em evento

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2021/12	Perturbation of endoplasmic reticulum-mitochondria crosstalk in bipolar disorder: effect of sigma-1 receptor modulation Arguente principal	Ana Rita Azevedo Henriques da Cunha (Mestrado) Universidade de Coimbra, Portugal
2021/10/11	Early autophagy dysfunction in Alzheimers disease: the role of WIPI2 Orientador	Emanuel Tahiri (Mestrado) Universidade de Coimbra, Portugal
2021	Desenvolvimento de um hidrogel de lisados de plaquetas para indução de regeneração nervosa Arguente principal	Joana Filipa Ribeiro Correia (Mestrado) Universidade de Aveiro, Portugal
2020/09/24	LAEB - Defesa de Monografia: "Development of new hydrogels for stem-cell differentiation" Arguente principal	Sofia Catarina Ponce Dias (Mestrado) Universidade de Aveiro Departamento de Física, Portugal
2019/09/12	Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth Arguente principal	João Miguel Miranda da Rocha (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/03	Study of Tau and Synaptogyrin-3 interaction - A drug discovery approach Arguente principal	Ana Filipa Martins de Oliveira (Mestrado) Hospitais da Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/27	Development of immunoassays on the Simoa platform to detect and differentiate Tau species at very low concentrations Arguente principal	Dina Rodrigues Martins (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/13	Assaying synaptic function using genetically -encoded optical reporters in the context of Alzheimer´s disease Arguente principal	Catarina Franco Quitério de Oliveira Borges (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/12	Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology Arguente principal	Joana de Freitas Fresco Rodrigues Costa (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/28	Apreciação do Projecto de tese: "The Role of endocytosis in BDNF-induced axonal outgrowth and branching" Arguente principal	Luís Filipe Maximino Martins (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/13	The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates Arguente principal	Alberto José Carpinteiro Soares (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/16	Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases Arguente principal	Nuno Miguel Ferreira Morais Apóstolo (Mestrado) Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2021/10 - Atual	Aging Cell
2017 - Atual	Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165)	Elsevier
2017 - Atual	Heliyon (2405-8440)	Elsevier
2017 - Atual	Oxidative Medicine and Cellular Longevity (1942-0994)	Hindawi Limited
2016 - Atual	Neurochemical Research (1573-6903)	Springer-Verlag
2015 - Atual	Data in Brief (2352-3409)	Elsevier

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2024/05/24 - Atual	From idea to publication of results: Cell cultures and other strategies.	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2022/11/25 - Atual	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, November 25th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.25 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2022/02/07 - Atual	Lecturer at the doctoral program - PDBEB course on 'Synapse Biology', University of Coimbra. 2022, February 7th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours)	Programa doutoral em Experimental Biology and Biomedicine (BEB) (Curso de doutoramento (conclusão de unidades curriculares))	Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/11/03 - Atual	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2021, November 3rd. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.4 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2021/03/22 - Atual	Lecturer at the doctoral program - PDBEB course on 'Synapse structure and function', University of Coimbra. 2021, March 22th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours)	Experimental Biology and Biomedicine (BEB)	Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2019/04/09 - Atual	Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, April 9th. (Lecture on the ¿Development of the nervous system and neuronal polarity and axon pathfinding¿, Total = 3 hours)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2014 - Atual	Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal.	(Mestrado)	Universidade de Coimbra, Portugal
2023/02/27 - 2023/03/01	Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2023, February 27th-March 1st. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours)	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2023/01/16 - 2023/01/20	Lecturer at the doctoral program - PDBEB course on 'Synapse assembly, function and plasticity (16-20 January 2023). 1 Lecture on the - Study of axonal transport and analysis with kymographs , Total = 1 week)	programa doutoral BEB	Universidade de Coimbra, Portugal
2022/12/02 - 2022/12/05	Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, December 2th and 5th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis, presentation of final works). Total = 6 hours) (MBC, MBCM, MBIOQ, MNMT)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2022/03/28 - 2022/03/30	Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2022, March 28th-30th. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours)	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2022/01/10 - 2022/01/10	Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2022, January 10th. (1 Lecture on neuronal development, Total = 2 hours)	Bioquímica (Licenciatura)	Universidade do Algarve, Portugal
2021/01/04 - 2021/01/04	Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2021, January 4th. (1 Lectures on neuronal development, Total = 2 hours)	Bioquímica (Licenciatura)	Universidade do Algarve, Portugal
2019/10/08 - 2019/10/08	Lecturer at the Cell regulation course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, October 8th. (Total = 2.5 hours)	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2019/03/25 - 2019/03/26	Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, March 25th-26th. (4 Lectures on the “Development of the nervous system and neuronal polarity and axon pathfinding”, Total = 4.5 hours)	Biologia Celular e Molecular (Mestrado)	Universidade de Coimbra, Portugal
2012 - 2014	Teacher of an Experimental Science Course – Cell Physiology and Molecular Biology lectured in the highschool “Escola Secundária de Oliveira do Bairro (ESOB)”, for students of “9º ano de escolaridade”. (4 courses of 10 classes, 3 hours each. Total = 120 hours)	Cell Physiology and Molecular Biology (Ensino secundário)	Instituto para a Educação e a Cidadania, Portugal
2013 - 2013	Invicted lecturer. Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. “Diverse Approaches To Molecular Mechanisms”. 1 lecture. Total = 3h	Medicina (Mestrado integrado)	Universidade de Coimbra, Portugal
2012 - 2013	Teacher in the Course "Do gene à proteína", lectured in the “Instituto para a Educação e a Cidadania (IEC), host in Mamarrosa, concelho de Oliveira do Bairro, Portugal. For highschool students. (8 classes, 3 hours each. Total = 24 hours)	(Ensino secundário)	Instituto para a Educação e a Cidadania, Portugal
2010 - 2010	Colaborator in Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. 2010.	Medicina (Mestrado integrado)	Universidade de Coimbra, Portugal
2007 - 2008	Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal.	Laboratory rotations for students of the Master in Cell and Molecular Biology (Mestrado)	Universidade de Coimbra, Portugal
2006 - 2006	Supervisor of laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine, CNC, University of Coimbra.	Laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	CNC.IBILI, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2019/08/09	Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author.	Diário as Beiras
2019/08/08	Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author.	Público
2013/03/28	Interview related to the program "pais com ciência" sponsored by "Ciência viva", in which the program "programa de ciência experimental para o ensino básico" was inserted. The advanced courses in "Cell Physiology and Molecular Biology Course", with the main function of science awareness, were lectured by Rui Costa and Pedro Alves to 48 students and 8 high school teacher during 2 years (2013-2014) at the ESOB (high school at Oliveira do Bairro, Portugal).	Diário da Bairrada

Entrevista / Programa (rádio / tv)

	Programa	Tema
2013/06/25 - 2013/06/25	RTP - Notícias. (The portuguese national tv channel). Interview regarding the advanced courses in Cell Physiology and Molecular Biology Course lectured by Rui O Costa and co-conceived by Rui O Costa and IEC (Instituto para a Educação e Cidadania) to high-school 48 students and 8 teachers for 2 years (2013-2014).	Cell Physiology and Molecular Biology

Membro de associação

	Nome da associação	Tipo de participação
2021/02 - Atual	Liga Portuguesa contra a Epilepsia (LPCE)	Member (Sócio)
2006 - Atual	Sociedade Portuguesa de Neurosciências (Portuguese Society for Neurosciences)	Member
2006 - Atual	Sociedade Portuguesa de Bioquímica (Portuguese society for Biochemistry)	Member

Tutoria

	Tópico	Nome do aluno
2023/02 - Atual	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). The role of hnRNP H2 in MRXSB.	Afonso Lourinho
2017 - Atual	PhD student tutoring at University of Coimbra, Portugal. "The effect of mesenchymal stem cells secretome on post-injury synapse formations"	Diogo Alexandre da Silva Tomé
2024/06 - 2024/07	The role of hnRNP H2 in epilepsy.	Ana Pinto
2023 - 2024	The role of hnRNP H2 in MRXSB	Afonso Lourinho
2021/10 - 2022/05	The role of BDNF in autophagy	Carlos Avilés Granados
2022/03/01 - 2022/03/31	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). Investigation of the role of BDNF in autophagy modulation of synaptic plasticity	João Videira Duarte Henriques
2022/03/01 - 2022/03/31	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Investigating the impact of Aß oligomers in the axonal retrograde transport of autophagic structures by JIP1	Rafael de Oliveira Patarra
2021/02/15 - 2021/06	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) )	Marta Sofia Santos Silva
2020/08/01 - 2020/10/31	Tutoring in summer course. Alterações nas sinápses GABAérgicas num modelo de epileptogénese in vitro.	Giorgio Belperio
2020/03 - 2020/07	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Anabela Pereira Tomás
2015/09 - 2019/09	PhD student tutoring at University of Coimbra, Portugal. " Secreted molecules in neuronal development and disease".	Luis Filipe Maximino Martins
2018 - 2018	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Magda Ferreira Rodrigues
2018 - 2018	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Raquel Sofia Inácio Pinto
2016 - 2016	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Diogo António Jarró Margato
2016 - 2016	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “)	Manuel Morais Jorge Coelho
2012 - 2013	Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) "	Rita Filipe de Almeida Neves
2011 - 2013	Master student tutoring at University of Coimbra, Portugal. "Role of local protein synthesis in presynaptogenesis."	Luís Filipe Maximino Martins
2008 - 2009	Master student tutoring at University of Coimbra, Portugal. "Neuroprotection by leptin and grelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease."	Isaura Vanessa Antunes Martins
2008/04 - 2008/08	Master student tutoring at the university of Coimbra, Portugal. "Role of Mithocondrial Dysfunction on Tau Hyperphosphorylation."	Alessandro De Stefano

Distinções

Prémio

2024	Best oral communication at "Encontro nacional de epileptologia" (ENE), Coimbra, 2024 Liga Portuguesa Contra a Epilepsia, Portugal
2022	Scientific Incentive Grant 2022 -Portuguese Epilepsy foundation (LPCE)
2022	Scholarship to attend the 8th European Synapse Meeting (ESM) (2022)
2013	Postdoctoral fellowship by FCT (SFRH/BPD/84593/2012) Fundação para a Ciência e a Tecnologia, Portugal
2007	Travel Grant to attend the 21s Bienal Meeting of the International Society for Neurochemistry FLAD - Fundação Luso Americana Para o desenvolvimento, Portugal
2007	Travel Grant to attend the 21st Bienal Meeting of the International Society for Neurochemistry SPB - Sociedade Portuguesa de Bioquímica, Portugal
2006	Full PhD fellowship by FCT (SFRH/BD/28403/2006) Fundação para a Ciência e a Tecnologia, Portugal

Título

2011	PhD in Biology Universidade de Coimbra, Portugal

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/04/23 - Atual	Invited speaker at the VI meet lab. O meet.Lab Coimbra é um evento organizado pelo Núcleo de Estudantes de Biologia da Associação Académica de Coimbra, com uma forte vertente de laboratório. Encontro	MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
2022 - Atual	HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022 Simpósio	HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
2015/11/19 - Atual	workshops@IIIUC, intitulada: “"Grant proposals: funding opportunities and writing tips” Oficina (workshop)	Grant proposals: funding opportunities and writing tips Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006 - Atual	Collaborator in “Brain Awarness Week” , at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra.	“Brain Awarness Week” CNC.IBILI, Portugal
2006 - Atual	Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra.	“Ciência Viva” programme CNC.IBILI, Portugal
2021/12/01 - 2021/12/03	XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, Coimbra, Portugal, from 1– 3 December 2021 Encontro	XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
2021/10/04 - 2021/10/07	EMBO Workshop Axons 2021; structure and function 4-7 October 2021. Participated with the poster: Thu-PO-3-19 Intra-axonal autophagy dysfunction in Alzheimer¿s disease. Rui O. Costa, Emanuel Tahiri, Marta Silva, Carlos B. Duarte Oficina (workshop)	EMBO Workshop: Axons 2021: structure and function
2021/03/12 - 2021/03/13	Congresso virtual da LPCE (33º eENE) Congresso	Congresso virtual da LPCE (33º eENE)
2020/01/23 - 2020/01/24	The Neurobiology of Socio-Sexual Behavior (6h of Lectures). This mini symposium was organized by the Center for Neuroscience and Cell Biology and the Master Program in Cellular and Molecular Biology of the University of Coimbra. Simpósio	The Neurobiology of Socio-Sexual Behavior CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016/06/17 - 2016/06/24	Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 (Duration 12h). Oficina (workshop)	Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2016/06/01 - 2016/06/04	ISN 2016 meeting, Coimbra, Portugal. Encontro	ISN 2016 (international society for neurochemistry)
2014/11/15 - 2014/11/19	SFN 2014 meeting, Washington DC, USA. Encontro	SFN 2014 meeting (Society for Neuroscience)
2012 - 2014	Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness. Advanced courses in Biology for students and high school teachers - "Curso avançado de Biologia Do gene à Proteína" Outro	Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness Instituto de Educação e Cidadania, Portugal
2013/05/27 - 2013/05/27	Workshop: "Grant Writing and Funding Opportunities" Oficina (workshop)	Workshop: "Grant Writing and Funding Opportunities" Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2012/12/04 - 2012/12/06	Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME); Zen imaging software. Coimbra, Portugal Oficina (workshop)	Advanced fluorescence microscopy workshop CNC.IBILI, Portugal
2010/11/29 - 2010/12/03	Image processing and analysis in cell physiology. Advanced Training Workshop Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal. Oficina (workshop)	Image processing and analysis in cell physiology. Universidade de Aveiro, Portugal
2010/07/03 - 2010/07/07	7th FENS, Fórum of European Neuroscience, Amsterdam, The Neatherlands. Encontro	7th FENS, Forum of European Neuroscience
2010/04/13 - 2010/04/13	Technical Seminar: “RNA World: not so small”. CNC, University of Coimbra, Portugal. Seminário	“RNA World: not so small”. CNC.IBILI, Portugal
2010/01/11 - 2010/01/15	Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC, University of Coimbra, Portugal. 2010, January 11th-15th. Outro	Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC. CNC.IBILI, Portugal
2009/09/02 - 2009/09/04	Course on Multifluorescence Microscopy. Training content: Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME). Coimbra, Portugal. 2009, September 2nd-4th. Oficina (workshop)	Course on Multifluorescence Microscopy CNC.IBILI, Portugal
2009/06/25 - 2009/06/26	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal. Encontro	24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
2009/03/11 - 2009/03/15	9th Internacional Conferente AD/PD, Prague, Czech Republic. Conferência	9th Internacional Conferente AD/PD, Prague, Czech Republic.
2008/06 - 2009/03	Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" given by Doctor William L. Kein, at Northwestern University, Evanston, Chicago. 2008, September-March. Outro	Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" lectured by Doctor William L. Kein Northwestern University - Chicago, Estados Unidos
2008/06/26 - 2008/06/27	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Encontro	23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2008/06/12 - 2008/06/16	6th FENS, Fórum of European Neuroscience, Geneva, Switzerland. Encontro	6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
2008/06/06 - 2008/06/07	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Encontro	22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/06/08 - 2007/06/09	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal. Encontro	21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/05/25 - 2007/05/26	Meeting Portuguese Society for Neurosciences, Ofir, Portugal. Encontro	Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
2007/01/29 - 2007/02/02	Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Outro	Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. 2007, January 29th-February 2nd. CNC.IBILI, Portugal
2007/01/22 - 2007/01/26	Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Outro	Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2007/01/15 - 2007/01/19	Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. Outro	Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2007/01/08 - 2007/01/10	Biostatistics. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal Outro	Biostatistics. Advanced course of PDBEB (Doctoral program) CNC.IBILI, Portugal
2006/12/08 - 2006/12/10	XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal. Congresso	XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
2006/11/23 - 2006/11/24	V Congresso de Investigação em Medicina, Coimbra, Portugal. Congresso	V Congresso de Investigação em Medicina (Congress on Investigation in Medicine), Coimbra, Portugal.
2006/06/23 - 2006/06/24	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal. Encontro	20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.