Alain José da Silva Morais (A513-378B-3139)

Curriculum Vitae

Alain José da Silva Morais

Alain Morais, BSc in Medical laboratory technology in 2000 and MSc in Biomedical Sciences in 2004, completed his PhD degree in Biomedical and Pharmaceutical Sciences in 2009. All educational formation obtained from the Université Catholique de Louvain (UCL), Belgium. The academic formation also includes a MAS in Biomedical Sciences and the FELASA/ICLAS (category C). During his academic course, A. Morais published 4 original papers and 1 review (cumulative impact factor of 41 and over 525 citations). He also participated in several national and international meetings with oral and posters presentations. All participations in international congress were granted by full EASL Young Investigators Bursaries. During his PhD, A. Morais has also joined the Interuniversity Gastroenterology Exchange program sponsored by SOLVAY PHARMA. After his PhD A. Morais moved to Portugal and, between January 2010 and December 2011, worked as post-doc at University of Minho (CBMA) granted by FCT (SFRH/BPD/62856/2009). The results obtained showed, for the first time, the existence of an EGFR protein paralog in yeast cell surface. During few months, he worked in France in the pharmaceutical company Macors as one of the responsible for the quality control of the main company¿s product: Movicol. This experience allowed him to enlarge his skills. On March 2013, A. Morais was hired as post-doc by the 3B's Research Group. Since then, A. Morais has worked closely with Stemmatters Company in the development of new ATMP for cartilage tissue engineering (TE) resulting in the submission of two patents and several oral and poster communications in national and international congress. With more than 19 scientific contributions in scientific journals with referee (most of them in high impact factor journals), participation in 2 patents, 6 book chapters in books with international circulation, A. Morais has an h-index of 14, receiving over 850 citations; and a RG of 28.74. Recently he was strongly involved in the FEDER-funded 3BioMeD project (FCT/4773/4/5/2017/S - €99.810,00 M) as well as on B-Liver project (2017 Call for SR&TD Project Grant - €238.601,47). At 3B's, the applicant has been involved on the field of biomaterials for biomedical applications and new in vivo models, namely for TE and orthopedics, with applications mainly directed to cartilage lesions. More recently, A. Morais has been involved on TE applications for meniscus, pancreas, liver and nerve conduct. As post-doc, he co-supervises unofficially the work of several PhD students.

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Identificação

Identificação pessoal

Nome completo: Alain José da Silva Morais

Nomes de citação

da Silva Morais, Alain

Identificadores de autor

Ciência ID: A513-378B-3139
ORCID iD: 0000-0001-5057-0819

Endereços de correio eletrónico

alain.morais@i3bs.uminho.pt (Profissional)

Moradas

3B's Research Group - Department of Polymer Engineering - University of Minho. Avepark - Parque de Ciência e Tecnologia - Zona Industrial da Gandra, 4805-017, Barco - Guimarães, Guimarães, Portugal (Profissional)

Websites

http://www.3bs.uminho.pt/ (Profissional)

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Francês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Português	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Espanhol; Castelhano	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2009/02/25 Concluído	PhD in Biomedical and Pharmaceutical Sciences (Docteur) Université catholique de Louvain Secteur des sciences de la santé, Bélgica "Role of the cascade PPARgamma - Adiponectin - AMPK in the control of hepatic fibrogenesis and steatohepatitis." (TESE/DISSERTAÇÃO)	Grande distinção
2008/06/30 Concluído	FELASA category C compulsory courses in laboratory animal science (Postgraduate Certificate) Université catholique de Louvain Secteur des sciences de la santé, Bélgica "n/a" (TESE/DISSERTAÇÃO)	Distinção
2007/09/01 Concluído	DES (DEA) Université catholique de Louvain Secteur des sciences de la santé, Bélgica "PPARgamma agonist, Pioglitazone, does not prevent hepatic fibrosis in mice" (TESE/DISSERTAÇÃO)	Grande distinção
2004/09/09 Concluído	Ciências biomédicas e experimentais (Licence) Université catholique de Louvain Secteur des sciences de la santé, Bélgica "Impact of the inhibition of the Ras oncoprotein on the liver regeneration in rats subjected to a partial hepatectomy" (TESE/DISSERTAÇÃO)	Distinção
2000/06/29 Concluído	B.S. in Medical Biology (Medical laboratory technologist) (Bachelor) Haute Ecole Leonard de Vinci Institut Paul Lambin, Bélgica "Evaluation of mutations in the hMSH2 gene in the hereditary non-polyposis colorectal cancer (HNPCC)" (TESE/DISSERTAÇÃO)	Satisfaz

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2013/03/01 - Atual	Pós-doutorado (Investigação)	Laboratório Associado ICVS 3B's, Portugal

2010/01/01 - 2011/12/31	Pós-doutorado (Investigação)	Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Outras Carreiras

	Categoria Profissional Instituição de acolhimento	Empregador
2012/05/23 - 2012/10/01	Técnico Superior (Técnico Superior)	Laboratoires Macors, França

Projetos

Bolsa

	Designação	Financiadores
2018/05/01 - 2019/01/31	Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche info:eu-repo/grantAgreement/EC/H2020/646075/EU Bolseiro de Pós-Doutoramento Laboratório Associado ICVS 3B's, Portugal	European Commission Em curso
2016/05/01 - 2018/04/28	An integrated multidisciplinary tissue engineering approach combining novel high-throughput screening and advanced methodologies to create complex biomaterials-stem cells constructs info:eu-repo/grantAgreement/EC/FP7/321266/EU Bolseiro de Pós-Doutoramento Laboratório Associado ICVS 3B's, Portugal	European Commission Concluído
2015/06/01 - 2015/09/30	Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to strengthen its competitive position at the European level info:eu-repo/grantAgreement/EC/FP7/316331/EU Bolseiro de Pós-Doutoramento Laboratório Associado ICVS 3B's, Portugal	European Commission Concluído
2015/01/06 - 2015/05/31	Integration of cutting-edge health science research and ground-breaking technologies for the development of new clinically useful therapies, tissue regeneration strategies, advanced prophylactic measures and diagnosis methods N-01-01-01-24-01-07 Bolseiro de Pós-Doutoramento Laboratório Associado ICVS 3B's, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluído
2013/01/03 - 2014/12/31	Development of new products and regenerative therapies for the treatment of articular pathologies QREN-13/SI/2011-23189 Bolseiro de Pós-Doutoramento Laboratório Associado ICVS 3B's, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluído
2009/11 - 2011/12	HumanYeast SFRH/BPD/62856/2009	Fundação para a Ciência e a Tecnologia

Projeto

	Designação	Financiadores
2019/02/01 - 2025/01/31	Não disponível DL 57/2016/CP1377/CT0086 Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/02/01 - 2024/01/31	Microcápsulas Poliméricas Obtidas por Automontagem Camada-a-Camada em Suportes Inorgânicos Com Capacidade de Encapsulamento Multimodal de Drogas Para o Tratamento do Cancro da Mama PTDC/CTM-REF/0022/2020 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/01 - 2022/06/30	Regeneração nervosa nano-acelerada com capacitação optogenética para o fortalecemento da funcionalidade neuromuscular PTDC/NAN-MAT/29936/2017 Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/01 - 2021/12/31	Exopolissacarídeo de Kefiran: Biopolímero promissor para uso em medicina regenerativa e engenharia de tecidos PTDC/BTM-MAT/29760/2017 Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017/02/01 - 2021/07/31	Biofabricação de estruturas 3D funcionalizadas para regeneração meniscal personalizada PTDC/BBB-ECT/2690/2014 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/09/01 - 2021/02/28	Estratégias de administração intratecal de células progenitoras encapsuladas em hidrogéis guiada por Imagiologia de Ressonância Magnética para o tratamento da esclerose lateral amiotrófica ENMed/0008/2015 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2011/12/31	HUMANYEAST SFRH/BPD/62856/2009	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em conferência	Ribeiro, V. P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, A. L.; Oliveira, J. M.; Reis, R. L.. "Combinatory approach for developing silk fibroin-based scaffolds seeded with human adipose-derived stem cells for a cartilage tissue engineering applications". Trabalho apresentado em TERMIS-EU, Davos, 2017. Publicado Vieira, Sílvia; da Silva Morais, Alain; Reis, R. L.; Oliveira, J. M.. "Gellan gum: a multifunctional tool to modulate cell microenvironment". 2017. Vieira S., Morais A., Reis R. L., Oliveira J. M. Gellan Gum: a Multifunctional Tool to Modulate Cell Microenvironment, Tissue Engineering Part A, Vol. 23, Issue S1, doi:10.1089/ten.tea.2017.29003.abstracts, 2017 da Silva Morais, Alain; Correia, Cristina; Vilela, Carlos A.; Gertrudes, Ana; Learmonth, David Alexander; Oliveira, Joaquim M.; Sousa, Rui A.; Reis, R. L.. "Development & performance assessment of a new ATMP for cartilage tissue engineering". 2016. 10.3389/conf.FBIOE.2016.01.02807 Ribeiro, Viviana Pinto; Silva-Correia, Joana; da Silva Morais, Alain; Correlo, V. M.; Marques, A. P.; Ribeiro, A. S.; Silva, Carla; et al. "Finely tuned fiber-based porous structures for bone tissue engineering applications". 2016. 10.3389/conf.FBIOE.2016.01.02658 da Silva Morais, Alain; Correia, Cristina; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "A one-step combined therapy for cartilage repair: Development & performance assessment.". Genova, 2014. Publicado • 10.1002/term.1931
Artigo em revista	Sandra Amaral; Tamara Lozano-Fernández; Juan Sabin; Amanda Gallego; Alain da Silva Morais; Rui L. Reis; África González-Fernández; Iva Pashkuleva; Ramon Novoa-Carballal. "End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine". International Journal of Biological Macromolecules 249 (2023): 125957-125957. http://dx.doi.org/10.1016/j.ijbiomac.2023.125957. 10.1016/j.ijbiomac.2023.125957 Marta R. Casanova; Paulo Mota; Helena Vala; Carmen Nóbrega; Alain da Silva Morais; Catarina S. Silva; Alexandre A. Barros; et al. "Functional recovery of injured cavernous nerves achieved through endogenous nerve growth factor-containing bioactive fibrous membrane". Acta Biomaterialia (2023): https://doi.org/10.1016/j.actbio.2023.07.015. 10.1016/j.actbio.2023.07.015 omar alheib; Lucilia P da Silva; Katia A Mesquita; Alain da Silva Morais; R.P. Pirraco; Rui L Reis; Vitor Manuel Correlo. "Human adipose-derived mesenchymal stem cells laden in gellan gum spongy-like hydrogels for volumetric muscle loss treatment". Biomedical Materials (2023): http://dx.doi.org/10.1088/1748-605x/acf25b. 10.1088/1748-605x/acf25b Helena R. Moreira; Daniel B. Rodrigues; Sara Freitas-Ribeiro; Lucília P. da Silva; Alain da S. Morais; Mariana Jarnalo; Ricardo Horta; et al. "Spongy-like hydrogels prevascularization with the adipose tissue vascular fraction delays cutaneous wound healing by sustaining inflammatory cell influx". Materials Today Bio 17 (2022): 100496-100496. http://dx.doi.org/10.1016/j.mtbio.2022.100496. 10.1016/j.mtbio.2022.100496 Helena R. Moreira; Daniel Barreira Rodrigues; Sara Freitas-Ribeiro; da Silva, L.P.; Alain da S. Morais; Mariana Jarnalo; Ricardo Horta; et al. "Integrin-specific hydrogels for growth factor-free vasculogenesis". npj Regenerative Medicine 7 1 (2022): http://dx.doi.org/10.1038/s41536-022-00253-4. 10.1038/s41536-022-00253-4 Omar Alheib; Lucília P. da Silva; Alain da Silva Morais; Katia A. Mesquita; Rogério P. Pirraco; Rui L. Reis; Vítor M. Correlo. "Injectable laminin-biofunctionalized gellan gum hydrogels loaded with myoblasts for skeletal muscle regeneration". Acta Biomaterialia 143 (2022): 282-294. https://doi.org/10.1016/j.actbio.2022.03.008. 10.1016/j.actbio.2022.03.008 "Methacrylated Gellan Gum/Poly-l-lysine Polyelectrolyte Complex Beads for Cell-Based Therapies". ACS Biomaterials Science & Engineering 7 10 (2021): 4898-4913. http://dx.doi.org/10.1021/acsbiomaterials.1c00486. 10.1021/acsbiomaterials.1c00486 Lara Pierantoni; Viviana P. Ribeiro; Lígia Costa; Sandra Pina; Alain da Silva Morais; Joana Silva-Correia; Subhas C. Kundu; et al. "Horseradish Peroxidase-Crosslinked Calcium-Containing Silk Fibroin Hydrogels as Artificial Matrices for Bone Cancer Research". Macromolecular Bioscience (2021): https://doi.org/10.1002/mabi.202000425. 10.1002/mabi.202000425 Oliveira, Isabel Matos; Gonçalves, Cristiana; Oliveira, Eduarda Pinheiro; Simón-Vázquez, Rosana; da Silva Morais, Alain; González-Fernández, África; Reis, Rui Luis; Oliveira, Joaquim Miguel. "PAMAM dendrimers functionalised with an anti-TNF a antibody and chondroitin sulphate for treatment of rheumatoid arthritis". Materials Science and Engineering: C 121 (2021): 111845. http://dx.doi.org/10.1016/j.msec.2020.111845. 10.1016/j.msec.2020.111845 Cengiz, Ibrahim Fatih; Maia, Fatima Raquel; da Silva Morais, Alain; Silva-Correia, Joana; Pereira, Helder; Canadas, Raphael F; Espregueira-Mendes, João; et al. "Entrapped in cage (EiC) scaffolds of 3D-printed polycaprolactone and porous silk fibroin for meniscus tissue engineering". Biofabrication (2020): http://dx.doi.org/10.1088/1758-5090/ab779f. Publicado • 10.1088/1758-5090/ab779f da Silva Morais, Alain; Vieira, Sílvia; Zhao, Xinlian; Mao, Zhengwei; Gao, Changyou; Oliveira, Joaquim M.; Reis, Rui L.. "Advanced Biomaterials and Processing Methods for Liver Regeneration: State-of-the-Art and Future Trends". Advanced Healthcare Materials (2020): 1901435. http://dx.doi.org/10.1002/adhm.201901435. Publicado • 10.1002/adhm.201901435 "Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering". Bio-Design and Manufacturing 2 4 (2019): 225-241. http://dx.doi.org/10.1007/s42242-019-00050-x. 10.1007/s42242-019-00050-x Vieira, Sílvia; da Silva Morais, Alain; Garet, Elina; Silva-Correia, Joana; Reis, Rui L.; González-Fernández, África; Miguel Oliveira, J.. "Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering". Acta Biomaterialia 93 (2019): 74-85. http://dx.doi.org/10.1016/j.actbio.2019.01.053. Publicado • 10.1016/j.actbio.2019.01.053 Canadas, Raphael F.; da Silva Morais, Alain; Patrício, P.; Gasperini, L.; Costa, J.; Araújo, N.; Reis, Rui L.; Marques, Alexandra P.; Oliveira, Joaquim M.. "Thermally-induced gradients in gels for programmable spatial distribution of bioactive factors". Journal of the American Chemical Society (2019): Submetido "Injectable gellan-gum/hydroxyapatite-based bilayered hydrogel composites for osteochondral tissue regeneration". Applied Materials Today 12 (2018): 309-321. http://dx.doi.org/10.1016/j.apmt.2018.06.005. 10.1016/j.apmt.2018.06.005 Carvalho, Cristiana R.; Costa, João B.; da Silva Morais, Alain; López-Cebral, Rita; Silva-Correia, Joana; Reis, Rui L.; Oliveira, J. Miguel. "Tunable Enzymatically Cross-Linked Silk Fibroin Tubular Conduits for Guided Tissue Regeneration". Advanced Healthcare Materials 7 17 (2018): 1800186. http://dx.doi.org/10.1002/adhm.201800186. Publicado • 10.1002/adhm.201800186 Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Canadas, Raphael F.; Costa, João B.; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration". Acta Biomaterialia 72 (2018): 167-181. http://dx.doi.org/10.1016/j.actbio.2018.03.047. Publicado • 10.1016/j.actbio.2018.03.047 Vilela, Carlos A.; Correia, Cristina; da Silva Morais, Alain; Santos, Tírcia C.; Gertrudes, Ana C.; Moreira, Elsa S.; Frias, Ana M.; et al. "In vitro and in vivo performance of methacrylated gellan gum hydrogel formulations for cartilage repair". Journal of Biomedical Materials Research Part A 106 7 (2018): 1987-1996. http://dx.doi.org/10.1002/jbm.a.36406. 10.1002/jbm.a.36406 Costa, João Bebiano; Silva-Correia, Joana; Ribeiro, Viviana Pinto; da Silva Morais, Alain; Oliveira, Joaquim Miguel; Reis, Rui Luís. "Engineering patient-specific bioprinted constructs for treatment of degenerated intervertebral disc". Materials Today Communications (2018): http://dx.doi.org/10.1016/j.mtcomm.2018.01.011. Publicado • 10.1016/j.mtcomm.2018.01.011 Ribeiro, Viviana P.; Silva-Correia, Joana; Nascimento, Ana I.; da Silva Morais, Alain; Marques, Alexandra P.; Ribeiro, Ana S.; Silva, Carla J.; et al. "Silk-based anisotropical 3D biotextiles for bone regeneration". Biomaterials 123 Supplement (2017): 92-106. http://dx.doi.org/10.1016/j.biomaterials.2017.01.027. Publicado • 10.1016/j.biomaterials.2017.01.027 Ondrésik, Marta; Azevedo Maia, Fatima R.; da Silva Morais, Alain; Gertrudes, Ana C.; Dias Bacelar, Ana H.; Correia, Cristina; Gonçalves, Cristiana; et al. "Management of knee osteoarthritis. Current status and future trends". Biotechnology and Bioengineering 114 4 (2016): 717-739. http://dx.doi.org/10.1002/bit.26182. 10.1002/bit.26182 Yan, Le-Ping; Silva-Correia, Joana; Ribeiro, Viviana P.; Miranda-Gonçalves, Vera; Correia, Cristina; da Silva Morais, Alain; Sousa, Rui A.; et al. "Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep31037. Publicado • 10.1038/srep31037 Correia, S. I.; Silva-Correia, J.; Pereira, H.; Canadas, R. F.; da Silva Morais, Alain; Frias, A. M.; Sousa, R. A.; et al. "Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus". Journal of Tissue Engineering and Regenerative Medicine 11 7 (2015): 1949-1962. http://dx.doi.org/10.1002/term.2092. Publicado • 10.1002/term.2092 da Silva Morais, Alain; Abarca-Quinones, Jorge; Guigas, Bruno; Viollet, Benoit; Stärkel, Peter; Horsmans, Yves; Leclercq, Isabelle A.; et al. "Development of hepatic fibrosis occurs normally in AMPK-deficient mice". Clinical Science 118 6 (2010): 411-420. http://dx.doi.org/10.1042/cs20090293. Publicado • 10.1042/cs20090293 da Silva Morais, Alain; Lebrun, Valérie; Abarca-Quinones, Jorge; Brichard, Sonia; Hue, Louis; Guigas, Bruno; Viollet, Benoit; Leclercq, Isabelle A.. "Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation". Journal of Hepatology 50 3 (2009): 489-500. http://dx.doi.org/10.1016/j.jhep.2008.10.027. Publicado • 10.1016/j.jhep.2008.10.027 da Silva Morais, Alain; Saliez, Alain; Leclercq, Isabelle; Horsmans, Yves; Stärkel, Peter; Da Silva Morais, A.; Saliez, A.; et al. "Inhibition of the Ras oncoprotein reduces proliferation of hepatocytesin vitroandin vivoin rats". Clinical Science 114 1 (2008): 73-83. http://dx.doi.org/10.1042/cs20070152. Publicado • 10.1042/cs20070152 Leclercq, Isabelle A.; Da Silva Morais, Alain; Schroyen, Ben; Van Hul, Noémi; Geerts, Albert. "Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences". Journal of Hepatology 47 1 (2007): 142-156. http://dx.doi.org/10.1016/j.jhep.2007.04.002. 10.1016/j.jhep.2007.04.002 da Silva Morais, Alain; Abarca-Quinones J; Horsmans Y; Stärkel P; Leclercq IA. "Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.". Int J Mol Med. (2007): http://europepmc.org/abstract/med/17143554. 10.3892/ijmm.19.1.105
Capítulo de livro	da Silva Morais, Alain; Oliveira, Joaquim Miguel; Reis, Rui L.. "Biomaterials and Microfluidics for Liver Models". In Biomaterials- and microfluidics-based tissue engineered 3D in vitro models, editado por Oliveira, Joaquim Miguel; Reis, Rui L.. Portugal: Springer, Berlin, Heidelberg, 2020. Aceite para publicação da Silva Morais, Alain; Oliveira, J. Miguel; Reis, Rui L.. "Small Animal Models". In Osteochondral tissue engineering: Challenges, current strategies, and technological advances, 423-439. Portugal: Springer International Publishing, 2018. Publicado • 10.1007/978-3-319-76735-2_19 Vilela, Carlos A.; da Silva Morais, Alain; Pina, Sandra Cristina Almeida; Oliveira, J. M.; Correlo, V. M.; Reis, R. L.; Espregueira-Mendes, João. "Clinical trials and management of osteochondral lesions". In Osteochondral Tissue Engineering, 391-413. Portugal: Springer, 2018. Publicado • 10.1007/978-3-319-76711-6_18 da Silva Morais, Alain; Oliveira, J. M.; Reis, R. L.. "Cartilage tissue engineering and regenerative strategies". In Regenerative Strategies for the Treatment of Knee Joint Disabilities, 73-96. Portugal: Springer International Publishing, 2017. Publicado • 10.1007/978-3-319-44785-8_5 da Silva Morais, Alain; Maia, F. Raquel; Reis, Rui L.; Oliveira, Joaquim M.. "Cell Culture Methods". In Bio-orthopaedics, 619-635. Portugal: Springer Berlin Heidelberg, 2017. Publicado • 10.1007/978-3-662-54181-4_49
Entrada de enciclopédia	Vieira, Sílvia; da Silva Morais, Alain; Silva-Correia, Joana; Oliveira, J. Miguel; Reis, Rui L.. "Natural-Based Hydrogels: From Processing to Applications". In Encyclopedia of Polymer Science and Technology. John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/0471440264.pst652. Publicado • 10.1002/0471440264.pst652
Poster em conferência	Ribeiro, Viviana P.; Cengiz, I. F.; Canadas, Raphael F.; Costa, João Bebiano; Vieira, Sílvia; da Silva Morais, Alain; Vilela, Carlos A.; et al. "Hierarchical bilayered silk fibroin scaffolds containing ZnSr-ß-TCP particles for osteochondral tissue regeneration". Trabalho apresentado em Chem2Nature, 2018. da Silva Morais, Alain; Reis, Rui L.; Oliveira, Joaquim M.. "Bioprinting of a perfusable liver implantable device for hepatic functions recovery and drugs screening". Trabalho apresentado em TERMSTEM/ForeCast, 2017. Vieira, Sílvia; da Silva Morais, Alain; Silva-Correia, Joana; Reis, Rui L.; Oliveira, Joaquim M.. "Gellan gum-based capsules for cell therapies". Trabalho apresentado em TERMSTEM/ FoReCaST, 2017. Costa, João Bebiano; Silva-Correia, Joana; Ribeiro, Viviana P.; da Silva Morais, Alain; Oliveira, Joaquim M.; Reis, Rui L.. "3D printing of patient-specific silk fibroin/elastina implants for intervertebral disc regeneration". Trabalho apresentado em TERMSTEM/FoReCaST, 2017. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Combinatory approach for developing silk fibroin-based scaffolds to support human adipose-derived stem cells chondrogenic differentiation". Trabalho apresentado em European Society for Biomaterials (ESB), 2017. da Silva Morais, Alain; Reis, Rui L.; Oliveira, Joaquim M.. "Tissue engineering approaches for liver regeneration". Trabalho apresentado em Chem2Nature second school, 2017. Ribeiro, Viviana P.; da Silva Morais, Alain; Maia, F. Raquel; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications". Trabalho apresentado em Society for Biomaterials (SFB), 2017. Ribeiro, Viviana P.; da Silva Morais, Alain; Oliveira, Ana L.; Oliveira, Joaquim M.; Reis, Rui L.. "Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications". Trabalho apresentado em Term Stem, 2016. Costa, João B.; Ribeiro, Viviana P.; Cengiz, I. F.; da Silva Morais, Alain; Silva-Correia, Joana; Oliveira, J. Miguel; Reis, Rui L.. "Advanced tissue engineering strategies for biofabrication of complex tissues". Trabalho apresentado em Term Stem, 2016. Vieira, Sílvia; Vial, Stephanie; da Silva Morais, Alain; Carvalho, Mariana Rodrigues; Reis, Rui L.; Oliveira, Joaquim M.; Reis, R. L.; Oliveira, J. M.. "Gellan-gum coated gold nanorods: A new tool for biomedical applications.". Trabalho apresentado em 10TH WORLD BIOMATERIALS CONGRESS (WBC), 2016. 10.3389/conf.FBIOE.2016.01.01358 Ribeiro, Viviana P.; da Silva Morais, Alain; Correlo, Vitor M.; Marques, Alexandra P.; Ribeiro, Ana; Silva, Carla; Durães, Nelson; et al. "Textile-based Silk Scaffolds for Bone Tissue Engineering Applications.". Trabalho apresentado em 27th European Conference on Biomaterials ESB2015, 2015. Correia, Cristina; Frias, Ana M.; Moreira, Elsa S.; Gertrudes, Ana C.; Costa, Dulce S.; Learmonth, David A.; Marques, Marisa; et al. "Steering progenitor cells from human adipose tissue along the clinical highway: Clinical grade manufacturing and ATMP development". Trabalho apresentado em ISSCR 2015, 2015. Canadas, Raphael F.; Pereira, Diana R.; Silva-Correia, Joana; Viegas, C.; da Silva Morais, Alain; Sousa, Rui A.; Marques, Alexandra P.; Reis, Rui L.; Oliveira, Joaquim M.. "In vivo performance of gellan gum-based structures: A comparison study between hydrogels and spongy-like scaffolds for osteochondral tissue regeneration". Trabalho apresentado em 5th ICVS/3B's Associated laboratory meeting, 2015. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "A one-step, off-the-shelf, minimally-invasive and non-angiogenic combined therapy that outperformed microfracture on cartilage repair". Trabalho apresentado em 12th World Congress of the International Cartilage Repair Society (ICRS), 2015. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Sousa, Rui A.; Reis, Rui L.. "Stem Cells from the adipose tissue as allogenic player in cartilage repair: in vivo performance". Trabalho apresentado em World Stem Cell Summit, 2014. Correia, Cristina; da Silva Morais, Alain; Vilela, Carlos A.; Radhouani, Hajer; Gonçalves, Cristiana; Gertrudes, Ana C.; Santos, Tírcia C.; et al. "In vitro and in vivo performance of an alternative therapy for osteoarthritis". Trabalho apresentado em TERMIS, 2014. da Silva Morais, Alain; Ferreira, Célia; Teixeira, Manuel; Lucas, Cândida. "The yeast Saccharomyces cerevisiae is sensitive to colorectal cancer routine treatment anti-EGFR antibody Cetuximab®". Trabalho apresentado em Microbiotec11, 2011. da Silva Morais, Alain; Abarca-Quinones, J.; Hue, L.; Viollet, B.; Horsmans, Y.; Leclercq, I.A.. "Impact of AMP-Activated Protein Kinase (AMPK) on the control of hepatic stellate cells (HSCs) activation in vitro". Trabalho apresentado em 43th Annual Meeting of the European Association for the Study of the Liver (EASL), 2008. da Silva Morais, Alain; Abarca-Quinones, J.; Stärkel, P.; Horsmans, Y.; Leclercq, I.A.. "PPARgamma ligand Pioglitazone does not prevent hepatic fibrosis in mice". Trabalho apresentado em 41th Annual Meeting of the European Association for the Study of the Liver (EASL), 2006. da Silva Morais, Alain; da Saeger, C.; Saliez, A.; Leclercq, I.A.; Horsmans, Y.; Stärkel, P.. "Inhibition of membrane anchorage of the Ras oncoprotein reduces hepatocyte proliferation in rats after partial hepatectomy". Trabalho apresentado em 40th Annual Meeting of the European Association for the Study of the Liver (EASL), 2005.

Propriedade Intelectual

Patente

Sousa, Rui Pedro Romero Amandi; Gertrudes, Ana C.; Correia, Cristina; da Silva Morais, Alain; Gonçalves, Cristiana; Radhouani, Hajer; Vilela, Carlos A.; et al. 2017. "Viscosupplement composition comprising ulvan for treating arthritis". Portugal.
Pendente
Sousa, Rui Pedro Romero Amandi; Correia, Cristina; Vilela, Carlos A.; da Silva Morais, Alain; Gertrudes, Ana C.; Santos, Tírcia C.; Oliveira, Joaquim M.; Espregueira-Mendes, João; Reis, Rui L.. 2015. "PRODUCTS FOR REPAIRING CARTILAGE LESIONS, METHOD OF PREPARATION AND USES THEREOF". Portugal.
Concedida/Emitida

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2018/04/12	Silk Fibroin/Elastin Bioinks for 3D Printing of Implants Respecting the Patient Intervertebral Disc Anatomy	Society For Biomaterials Annual Meeting & Exposition Society For Biomaterials (Atlanta, Estados Unidos)
2017/06/26	Combinatory approach for developing silk fibroin-based scaffolds seeded with human adipose-derived stem cells for a cartilage tissue engineering applications	TERMIS EU TERMIS EU (Davos, Suiça)
2017/06/06	Gellan gum-based capsules for cell therapies	Chem2Nature second school Chem2Nature (Porto, Portugal)
2016/10/28	Enzymatically cross-linked silk fibroin scaffolds support human adipose-derived stem cells chondrogenesis for cartilage tissue engineering applications.	TERMSTEM TERMSTEM (Guimarães, Portugal)
2016/05/22	Finely tuned fiber-based porous structures for bone tissue engineering applications.	10TH WORLD BIOMATERIALS CONGRESS (WBC) WORLD BIOMATERIALS CONGRESS (Montreal, Canadá)
2016/05/18	Development & Performance Assessment of a New ATMP for Cartilage Tissue Engineering.	10TH WORLD BIOMATERIALS CONGRESS WORLD BIOMATERIALS CONGRESS (Montreal)
2015/06/30	Nanoparticle-induced bioprinted liver for drug screening and tissue regeneration.	2ND POLARIS WORKSHOP CONFERENCE POLARIS (Guimarães, Portugal)
2015/05/14	Complex 3D Architectures Based on Knitting Technologies for Bone Tissue Engineering Applications.	MEDTEX2015 MEDTEX2015 (Lodz, Polónia)
2014/10/23	Cartilage repair by a non-invansive one-step combined therapy.	TERMSTEM TERMSTEM (Porto, Portugal)
2014/06/10	A one-step combined therapy for cartilage repair: Development & performance assessment.	TERMIS TERMIS (Genova, Itália)
2008/04/25	Adiponectin-dependent activation of AMPK, but not of PPARa, is implicated in the preventive effect of pioglitazone on the steatohepatitis.	43th Annual Meeting of the European Association for the Study of the Liver (EASL) European Association for the Study of the Liver (EASL) (Milan, Itália)
2008/02/22	Adiponectin-dependent activation of AMPK, but not of PPARa, is implicated in the preventive effect of pioglitazone on the steatohepatitis.	20th Belgian Week of Gastroenterology Belgian Association for the Study of the Liver (Antwerp, Bélgica)
2008/02/21	Impact of AMP-Activated Protein Kinase (AMPK) on the control of hepatic stellate cells (HSCs) activation in vitro	20th Belgian Week of Gastroenterology Belgian Association for the Study of the Liver (Antwerp, Bélgica)
2006/02/09	PPARg ligand Pioglitazone does not prevent hepatic fibrosis in mice	18th Belgian Week of Gastroenterology Belgian Association for the Study of the Liver (Ostende, Bélgica)
2005/02/24	Inhibition of membrane anchorage of the Ras oncoprotein reduces hepatocyte proliferation in rats after partial hepatectomy	17th Belgian Week of Gastroenterology Belgian Association for the Study of the Liver (Spa)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2005/03/23 - 2006/02/02	Interuniversity Gastroenterology Exchange program Seminário	Interuniversity Gastroenterology Exchange program / Solvay Pharma Université catholique de Louvain Bibliothèque des sciences de la santé, Bélgica
2006/01/27 - 2006/01/29	EASL School of Hepatology Oficina (workshop)	EASL School of Hepatology European Association for the Study of the Liver, Suiça
2005/04/22 - 2005/04/22	The stellate cell-myofibroblast transition in pathological organ remodelling Oficina (workshop)	The stellate cell-myofibroblast transition in pathological organ remodelling Vrije Universiteit Brussel, Bélgica

Distinções

Prémio

2008	Young investigator bursary European Association for the Study of the Liver (EASL) European Association for the Study of the Liver, Suiça
2006	Young investigator bursary European Association for the Study of the Liver (EASL) European Association for the Study of the Liver, Suiça
2005	Young investigator bursary European Association for the Study of the Liver (EASL) European Association for the Study of the Liver, Suiça