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Iva Pashkuleva has a PhD in Organic Chemistry from University of Sofia, Bulgaria. In 2002, she moved to University of Minho, Portugal where started research activities in the area of Biomaterials - she was awarded a Postdoctoral fellowship from Portuguese Foundation for Science and Technology (FCT) to develop her project on surface characterization and modification of starch-based biomaterials. In 2008, she received Career Starting Grant under the Portuguese National Program Compromisso com a Ciência. During this period, Pashkuleva kept her research focus on surface modification of biomaterials (with emphasis on starch and chitosan) as a way to enhance their biocompatibility. She was principal investigator (PI) of two European projects that enabled her to build own network of international collaborations both in academy and industry. In the following period, she was awarded two Development Career Grants: in 2013 under the Portuguese Program Investigador FCT and in 2019 under the programme for Individual Scientific Employment Stimulus. During this last period, Pashkuleva established a new research line focussed on biofunctional glycans and built a small research team, whose core is currently composed by 1 Research associate, 2 Junior researchers, and 2 PhD students. Pashkuleva and her team are working on the elucidation of glycans role in cellular communication and the possibility to explore glycans in design and synthesis of functional biomaterials. They have developed new analytical methods and platforms for characterization of challenging to measure glycan-protein and glycan-cell interactions. Advancements in glycan-based delivery systems were achieved by development of new designs and concepts. The use of glycans in cancer therapies was also explored: for the first-time glycan amphiphiles were used as substrates in selective biocatalytic approach. Extracellular supramolecular mimics were generated by self-assembly of glycans and proteins or their functional simpler analogues carbohydrates and peptides. As PI and Co-PI she successfully obtained funding from FCT and EC in a total amount of approx 5M euros. She has also participated in proposals preparation and research teams of National granted Projects corresponding to a total budget of about 0.87M euros and EC projects corresponding to a total budget of over 3.52M euros. Her expertise has been recognised by different evaluation agencies and peers. She has been acting as a member of different MSc and PhD examination panels and as External Evaluator of Project proposals for EU (H2020, ERA-NET) and different national foundations (Czech Science Foundation, Swiss National Science Foundation, EMPA co-fund programme). During the last years she has been acting as a referee for peer-reviewed journals form Elsevier, Wiley, Taylor & Francis, RSC, ACS. Since 2018, she is an Academic editor for PlosOne, editorial board member of Molecules (MDPI), Cells (MDPI) and a review editor of Frontiers in Bioengineering and Biotechnology. Since 2018, Pashkuleva has been supervisor of 6 MSc students, 6 PhD students, and several postdoctoral researchers. During this period, 3 PhD and 4 MSc students defended their theses under her supervision and now, they are successful professionals in the academy, research centers or in the industry. The training at advanced (PostDoc) level has been well-recompensated as the researchers mentored by her have been very successful in pursuing the prestigious international fellowships such as Marie Curie and Ramon y Cajal, but also competitive national grants (FCT CEEC: 2 Junior, 2 Auxiliar and 1 Development grants). Pashkuleva is an elected member of the General Council of the Research Institute of Biomaterials, Biodegradables and Biomimetics (I3Bs) and the Quality Assurance team of the same Institute. She also takes part of the PhD programme in Tissue engineering, regenerative medicine (TERM) and stem cells as well as of the UMinho online course in TERM.
Identificação

Identificação pessoal

Nome completo
Iva Pashkuleva

Nomes de citação

  • Pashkuleva, Iva

Identificadores de autor

Ciência ID
A61F-4AAC-1C34
ORCID iD
0000-0001-6818-3374
Google Scholar ID
https://scholar.google.pt/citations?user=5NL6DDwAAAAJ&hl=en
Researcher Id
B-5590-2008
Scopus Author Id
57197790406

Telefones

Telefone
  • 253510 Ext.: 906 (Profissional)

Moradas

  • AvePark, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia dos Materiais
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Búlgaro (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador independente (B2) Utilizador proficiente (C1) Utilizador elementar (A2) Utilizador independente (B2)
Russo Utilizador elementar (A2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B1)
Formação
Grau Classificação
2001 - 2007
Concluído
Biomaterials (Pós-doutoramento)
Especialização em Surface modification of starch-based biomaterials
Universidade do Minho, Portugal
1996 - 2000
Concluído
Organic chemistry (Doctor of Philosophy)
Sofiski universitet Sveti Kliment Ohridski, Bulgária
"Reaction of Schiff bases of benzylamine with some derivatives of cinnamic acid and azomethines under phase-transfer catalysed conditions" (TESE/DISSERTAÇÃO)
1990 - 1995
Concluído
Organic and Analytical Chemistry (Master)
Sofiski universitet Sveti Kliment Ohridski, Bulgária
"Addition of ethyl N-(diphenylmethylene)glycinate to azomethines under phase-transfer catalysed conditions" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013/12/16 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho, Portugal
2008 - 2013 Investigador Auxiliar (carreira) (Investigação) Universidade do Minho, Portugal
2001 - 2007 Pós-doutorado (Investigação) Universidade do Minho, Portugal
Universidade do Minho Departamento de Engenharia de Polímeros, Portugal
1999 - 2000 Investigador (Investigação) Balgarska academija na naukite, Bulgária

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2000 - 2001 Professor Auxiliar (Docente Universitário) Sofiski universitet Sveti Kliment Ohridski, Bulgária
1996 - 1999 Assistente Convidado (Docente Universitário) Sofiski universitet Sveti Kliment Ohridski, Bulgária
Projetos

Bolsa

Designação Financiadores
2020 - 2024 Bioadhesive materials for spinal cord regeneration
SFRH/BD/143209/2019
Orientador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2021 NANOGLYCAN: Glycotools for elucidating molecular and cellular interaction of glycans in vitro
SFRH/BD/114847/2016
Orientador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2013/03/01 - 2019 SULFOCODE: SURFACES MIMICKING SULFONATED GAGS AS PLATFORMS FOR STUDYING THE MECHANISMS BEHIND CELL-GAGS INTERACTIONS
SFRH/BPD/85790/2012
Orientador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2022/12 - 2027/11 APTADEGRAD: A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds
Investigador responsável
Horizon 2020
Em curso
2022/01/01 - 2024/12/31 SpyPatch: Modular spider silk and elastin recombinamers for soft tissue repair patches
PTDC/BTM-MAT/2844/2021
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2021/01 - 2024/12 OncoNeoTreat: Inorganic-Templated and Polymeric Layer-by-Layer Microcapsules with Multimodal Drug Loading to Treat Breast Cancer
PTDC/CTM-REF/0022/2020
Co-Investigador Responsável (Co-IR)
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 CardioHeal: Self-healing hydrogels with extracellular matrix analogues for cardiac tissue engineering
PTDC/BTM-MAT/28327/2017
Investigador responsável
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 CARTI-LIKE: Reconstruction of cartilage nanostructure by brush like copolymers that mimic proteoglycans
PTDC/QUI-POL/28117/2017
Co-Investigador Responsável (Co-IR)
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 CANCER_CAGE: Smart carbohydrate nanonets for selective anticancer therapies
PTDC/NAN-MAT/28468/2017
2018-2020 Co-PI; 2021 Researcher
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 SeaJellyBone: Multifunctional hydrogels inspired by mussels that combine bioactivity with superior adhesion for bone tissue regeneration
PTDC/BTM-MAT/28123/2017
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Bioactive coatings containing new BioGlass nanoparticles for orthopedic applications
PTDC/NAN-MAT/31036/2017
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/01 - 2020/12 GLYCONET: Depriving cancer glycolysis by aromatic N-glucosides that act as GLUT1 antagonists and substrates for biocatalytic self-assembly
LPCC-NRN 2020
Investigador responsável
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Concluído
2015/06 - 2019/05 ELASTISLET: Tailored elastin-like recombinamers as advanced systems for cell therapies in diabetes mellitus: a synthetic biology approach towards a bioeffective and immunoisolated biosimilar islet/cell niche
Investigador
Universidade do Minho, Portugal
Horizon 2020
Concluído
2016/01 - 2018/12 CHEM2NATURE: Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices
Universidade do Minho, Portugal
Horizon 2020
Concluído
2016 - 2018 CytoNanoHeal: Engineered nanotools for advanced cell therapies
ENMed/0001/2015
Investigador responsável
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2018 SWEETLIFE: Glycans as a third language of life beyond proteins and nucleic acid
IF/00032/2013
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2012/10 - 2015/09 POLARIS: Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to stengthen its competitive position at the European level
Orientador
Universidade do Minho, Portugal
European Commission
Concluído
2011/01 - 2013/12 EpitHope - Advanced Biomimetic Regenerative Strategies for Active Targeting Degenerative Articular Cartilage
PTDC/EBB-BIO/114523/2009
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 TISSUE2TISSUE-Using Textile Technologies to Develop Innovative 3D Architectures to Be Applied in Bone Tissue Engineering
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/10 - 2013/09 Find and Bind: Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological application
Investigador responsável
Universidade do Minho, Portugal
European Commission
Concluído
2007/04 - 2010/03 PhotoNanoTech: Photozyme Nanoparticle Applications for Water Purification, Textile Finishing, Photodynamic Biomineralization and Biomaterials Coating
Investigador responsável
Universidade do Minho, Portugal
European Commission
Concluído
2005/01 - 2008/05 SMARTSCAFF- Polymeric 3D Scaffolds with Tailor-Made Surfaces for Bone Tissue Engineering
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Chiono, V.; Carmagnola, I.; Gentile, P.; Boccafoschi, F.; Tonda-Turo, C.; Ciardelli, G.; Georgiev, G.; et al. "Layer-by-layer coating of photoactive polymers for biomedical applications". 2009.
Artigo em revista
  1. Rui R. Costa; Vicente Domínguez-Arca; Brenda Velasco; Rui L. Reis; José Carlos Rodríguez-Cabello; Iva Pashkuleva; Pablo Taboada; Gerardo Prieto. "Cholesterol Conjugated Elastin-like Recombinamers: Molecular Dynamics Simulations, Conformational Changes, and Bioactivity". ACS Applied Materials & Interfaces (2024): https://doi.org/10.1021/acsami.4c07285.
    10.1021/acsami.4c07285
  2. Sara A. Martins; Rui R. Costa; Alexandra Brito; Rui L. Reis; Natália M. Alves; Iva Pashkuleva; Diana Soares da Costa. "Multifunctional calcium-based nanocarriers for synergistic treatment of triple-negative breast cancer". Journal of Colloid and Interface Science (2024): https://doi.org/10.1016/j.jcis.2024.06.159.
    10.1016/j.jcis.2024.06.159
  3. Eduarda Fernandes; Rui R. Costa; Raúl Machado; Rui L. Reis; Iva Pashkuleva; Marlene Lúcio. "A Label-Free Multitechnique Approach to Characterize the Interaction of Bioactive Compounds with Biomimetic Interfaces". Small Science (2024): https://doi.org/10.1002/smsc.202300271.
    10.1002/smsc.202300271
  4. Diogo Duarte; Cátia Correia; Rui L. Reis; Iva Pashkuleva; Daniela Peixoto; Natália M. Alves. "Bioadhesive Hyaluronic Acid-Based Hydrogels for Spinal Cord Injury". Biomacromolecules (2024): https://doi.org/10.1021/acs.biomac.3c01186.
    10.1021/acs.biomac.3c01186
  5. Vânia I. B. Castro; Yuting Gao; Alexandra Brito; Jie Chen; Rui L. Reis; Iva Pashkuleva; Ricardo A. Pires. "Cooling rate uncovers epimer-dependent supramolecular organization of carbohydrate amphiphiles". Journal of Materials Chemistry B (2024): https://doi.org/10.1039/D4TB00728J.
    10.1039/D4TB00728J
  6. Fontelo, Raul; Reis, Rui L.; Novoa-Carballal, Ramon; Pashkuleva, Iva. "Preparation, Properties, and Bioapplications of Block Copolymer Nanopatterns". Advanced Healthcare Materials 13 1 (2023): http://dx.doi.org/10.1002/adhm.202301810.
    10.1002/adhm.202301810
  7. Bastos, Filipa R.; Soares da Costa, Diana; Reis, Rui L.; Alves, Natália M.; Pashkuleva, Iva; Costa, Rui R.. "Layer-by-layer coated calcium carbonate nanoparticles for targeting breast cancer cells". Biomaterials Advances 153 (2023): 213563. http://dx.doi.org/10.1016/j.bioadv.2023.213563.
    Publicado • 10.1016/j.bioadv.2023.213563
  8. Amaral, Sandra; Lozano-Fernández, Tamara; Sabin, Juan; Gallego, Amanda; da Silva Morais, Alain; Reis, Rui L.; González-Fernández, África; Pashkuleva, Iva; Novoa-Carballal, Ramon. "End-on PEGylation of heparin: Effect on anticoagulant activity and complexation with protamine". International Journal of Biological Macromolecules 249 (2023): 125957. http://dx.doi.org/10.1016/j.ijbiomac.2023.125957.
    Publicado • 10.1016/j.ijbiomac.2023.125957
  9. Rui R. Costa; David Caballero; Diana Soares da Costa; Romen Rodriguez-Trujillo; Subhas C. Kundu; Rui L. Reis; Iva Pashkuleva. "Microfluidic-Assisted Interfacial Complexation of Extracellular Matrix Components to Mimic the Properties of Neural Tissues". Advanced Materials Technologies (2023): https://doi.org/10.1002/admt.202300983.
    10.1002/admt.202300983
  10. Vânia I.B. Castro; Ana R. Araújo; Filipa Duarte; António Sousa-Franco; Rui L. Reis; Iva Pashkuleva; Ricardo A. Pires. "Glycopeptide-Based Supramolecular Hydrogels Induce Differentiation of Adipose Stem Cells into Neural Lineages". ACS Applied Materials & Interfaces (2023): https://doi.org/10.1021/acsami.3c05309.
    10.1021/acsami.3c05309
  11. Cátia Correia; Rui L. Reis; Iva Pashkuleva; Natália M. Alves. "Adhesive and self-healing materials for central nervous system repair". Biomaterials Advances (2023): 213439-213439. http://dx.doi.org/10.1016/j.bioadv.2023.213439.
    10.1016/j.bioadv.2023.213439
  12. Ana M. Martins; Alexandra Brito; Maria Grazia Barbato; Alessia Felici; Rui L. Reis; Ricardo A. Pires; Iva Pashkuleva; Paolo Decuzzi. "Efficacy of molecular and nano-therapies on brain tumor models in microfluidic devices". Biomaterials Advances 144 (2023): 213227-213227. http://dx.doi.org/10.1016/j.bioadv.2022.213227.
    10.1016/j.bioadv.2022.213227
  13. Cátia Correia; Diana Soares da Costa; Ana Rita Inácio; A. Catarina Vale; Daniela Peixoto; Tiago H. Silva; Rui L. Reis; Iva Pashkuleva; Natália M. Alves. "Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan". ACS Sustainable Chemistry & Engineering (2022): https://doi.org/10.1021/acssuschemeng.2c05144.
    10.1021/acssuschemeng.2c05144
  14. Ana M. Carvalho; Rui L. Reis; Iva Pashkuleva. "Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment". Advanced Healthcare Materials (2022): https://doi.org/10.1002/adhm.202202118.
    10.1002/adhm.202202118
  15. Ana M. Carvalho; Jesus Valcarcel; Diana Soares da Costa; Marisa Gomes; José Antonio Vázquez; Rui L. Reis; Ramon Novoa-Carballal; Iva Pashkuleva. "Hyaluronan Brush-like Copolymers Promote CD44 Declustering in Breast Cancer Cells". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c11864.
    10.1021/acsami.2c11864
  16. Ana M. Carvalho; Diana Soares da Costa; Rui L. Reis; Iva Pashkuleva. "RHAMM expression tunes the response of breast cancer cell lines to hyaluronan". Acta Biomaterialia (2022): https://doi.org/10.1016/j.actbio.2022.05.013.
    10.1016/j.actbio.2022.05.013
  17. Correia, Cátia; Sousa, Rita O.; Vale, A. Catarina; Peixoto, Daniela; Silva, Tiago H.; Reis, Rui L.; Pashkuleva, Iva; Alves, Natália M.. "Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan". Colloids and Surfaces B: Biointerfaces 213 (2022): 112409. http://dx.doi.org/10.1016/j.colsurfb.2022.112409.
    10.1016/j.colsurfb.2022.112409
  18. Fontelo, R.; Soares da Costa, D.; Reis, R.L.; Novoa-Carballal, R.; Pashkuleva, I.. "Antithrombotic and hemocompatible properties of nanostructured coatings assembled from block copolymers". Journal of Colloid and Interface Science 608 (2022): 1608-1618. http://dx.doi.org/10.1016/j.jcis.2021.10.076.
    10.1016/j.jcis.2021.10.076
  19. Rui R. Costa; Rui L. Reis; Iva Pashkuleva. "Glycosaminoglycans as polyelectrolytes: implications in bioactivity and assembly of biomedical devices". International Materials Reviews (2022): https://doi.org/10.1080/09506608.2022.2026860.
    10.1080/09506608.2022.2026860
  20. Raul Fontelo; Diana Soares da Costa; Manuel Gomez-Florit; Hanna Tiainen; Rui L. Reis; Ramon Novoa-Carballal; Iva Pashkuleva. "Antibacterial nanopatterned coatings for dental implants". Journal of Materials Chemistry B (2022): https://doi.org/10.1039/D2TB01352E.
    10.1039/D2TB01352E
  21. Alexandra Brito; Dhwanit Dave; Ayala Lampel; Vânia I. B. Castro; Daniela Kroiss; Rui L. Reis; Tell Tuttle; et al. "Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation". Journal of the American Chemical Society (2021): https://doi.org/10.1021/jacs.1c07592.
    10.1021/jacs.1c07592
  22. Ana M. Carvalho; Diana Soares da Costa; Rui L. Reis; Iva Pashkuleva. "Influence of Hyaluronan Density on the Behavior of Breast Cancer Cells with Different CD44 Expression". Advanced Healthcare Materials (2021): 2101309-2101309. https://doi.org/10.1002/adhm.202101309.
    10.1002/adhm.202101309
  23. Pashkuleva, Iva. "Liposomes embedded in layer by layer constructs as simplistic extracellular vesicles transfer model". Materials Science and Engineering: C 121 (2021): 111813-111813. http://dx.doi.org/10.1016/j.msec.2020.111813.
    10.1016/j.msec.2020.111813
  24. Amorim, Sara; Soares da Costa, Diana; Mereiter, Stefan; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.. "Multilayer platform to model the bioactivity of hyaluronic acid in gastric cancer". Materials Science and Engineering: C 119 (2021): 111616. http://dx.doi.org/10.1016/j.msec.2020.111616.
    10.1016/j.msec.2020.111616
  25. Ana M. Carvalho; Diana Soares da Costa; Pedro M.R. Paulo; Rui L. Reis; Iva Pashkuleva. "Co-localization and crosstalk between CD44 and RHAMM depend on hyaluronan presentation". Acta Biomaterialia 119 (2021): 114-124. http://dx.doi.org/10.1016/j.actbio.2020.10.024.
    10.1016/j.actbio.2020.10.024
  26. Amorim, Sara; Soares da Costa, Diana; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.; Sara Amorim; et al. "3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells". Biomaterials Science 9 1 (2021): 252-260. http://dx.doi.org/10.1039/d0bm00843e.
    10.1039/d0bm00843e
  27. Amorim, Sara; Soares da Costa, Diana; Pashkuleva, Iva; Reis, Celso A.; Reis, Rui L.; Pires, Ricardo A.. "Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells". Advanced Biosystems 4 11 (2020): 2000122. http://dx.doi.org/10.1002/adbi.202000122.
    10.1002/adbi.202000122
  28. Yankova, Iveta; Shestakova, Pavletta; Reis, Rui L.; Pashkuleva, Iva; Vassileva, Elena. "Gelatin micro- and nanocapsules obtained via sonochemical method". Journal of Applied Polymer Science 137 48 (2020): 49584. http://dx.doi.org/10.1002/app.49584.
    10.1002/app.49584
  29. Soares da Costa, Diana; Sousa, João C.; Dá Mesquita, Sandro; Petkova-Yankova, Nevena I.; Marques, Fernanda; Reis, Rui L.; Sousa, Nuno; Pashkuleva, Iva. "Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development". Molecules 25 4 (2020): 795. http://dx.doi.org/10.3390/molecules25040795.
    Publicado • 10.3390/molecules25040795
  30. Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1". Chemical Science (2020): https://doi.org/10.1039/D0SC00954G.
    10.1039/D0SC00954G
  31. Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44". Journal of Materials Chemistry B (2020): https://doi.org/10.1039/D0TB00407C.
    10.1039/D0TB00407C
  32. Alexandra Brito; Patrícia M. R. Pereira; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse". Nanoscale (2020): https://doi.org/10.1039/D0NR05008C.
    10.1039/D0NR05008C
  33. Ramón Rial; Rui R. Costa; Rui L. Reis; Zhen Liu; Iva Pashkuleva; Juan M. Ruso. "Mineralization of Layer-by-Layer Ultrathin Films Containing Microfluidic-Produced Hydroxyapatite Nanorods". Crystal Growth & Design (2019): https://doi.org/10.1021/acs.cgd.9b00831.
    10.1021/acs.cgd.9b00831
  34. Costa, Rui R.; Soares da Costa, Diana; Reis, Rui L.; Pashkuleva, Iva. "Bioinspired baroplastic glycosaminoglycan sealants for soft tissues". Acta Biomaterialia 87 (2019): 108-117. http://dx.doi.org/10.1016/j.actbio.2019.01.040.
    10.1016/j.actbio.2019.01.040
  35. Alexandra Brito; Yousef M. Abul-Haija; Diana Soares da Costa; Ramon Novoa-Carballal; Rui L. Reis; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva. "Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles". Chemical Science (2019): https://doi.org/10.1039/C8SC04361B.
    10.1039/C8SC04361B
  36. Sara Amorim; Diana Soares da Costa; Daniela Freitas; Celso A. Reis; Rui L. Reis; Iva Pashkuleva; Ricardo A. Pires. "Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-34445-0.
    10.1038/s41598-018-34445-0
  37. Ramon Novoa-Carballal; Agatha Carretero; Raul Pacheco; Rui L. Reis; Iva Pashkuleva. "Star-Like Glycosaminoglycans with Superior Bioactivity Assemble with Proteins into Microfibers". Chemistry - A European Journal 24 54 (2018): 14341-14345. https://doi.org/10.1002/chem.201802243.
    10.1002/chem.201802243
  38. Rui R. Costa; Miguel González-Pérez; Marcos Herrero-Gutiérrez; Ricardo A. Pires; Matilde Alonso; J. Carlos Rodriguez-Cabello; Rui L. Reis; Iva Pashkuleva. "Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00723.
    10.1021/acs.biomac.8b00723
  39. Ana M. Carvalho; Raquel Teixeira; Ramón Novoa-Carballal; Ricardo A. Pires; Rui L. Reis; Iva Pashkuleva. "Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00561.
    10.1021/acs.biomac.8b00561
  40. Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.. "Sulfation of Glycosaminoglycans and Its Implications in Human Health and Disorders". Annual Review of Biomedical Engineering 19 (2017): 1-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021172739&partnerID=MN8TOARS.
    Publicado • 10.1146/annurev-bioeng-071516-044610
  41. Silva, C.; Carretero, A.; Soares da Costa, D.; Reis, R.L.; Novoa-Carballal, R.; Pashkuleva, I.. "Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors". Acta Biomaterialia 63 (2017): 283-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029607589&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.08.042
  42. Oliveira, C.; Ferreira, A.S.; Novoa-Carballal, R.; Nunes, C.; Pashkuleva, I.; Neves, N.M.; Coimbra, M.A.; et al. "The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity". Macromolecular Bioscience 17 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009179205&partnerID=MN8TOARS.
    10.1002/mabi.201600340
  43. Ribeiro, V.P.; Almeida, L.R.; Martins, A.R.; Pashkuleva, I.; Marques, A.P.; Ribeiro, A.S.; Silva, C.J.; et al. "Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applications". Journal of Tissue Engineering and Regenerative Medicine 11 10 (2017): 2853-2863. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978872476&partnerID=MN8TOARS.
    10.1002/term.2189
  44. A. Carretero; D. Soares da Costa; R. L. Reis; I. Pashkuleva; Carretero, A.; Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.. "Extracellular matrix-inspired assembly of glycosaminoglycan–collagen fibers". Journal of Materials Chemistry B 5 17 (2017): 3103-3106. https://doi.org/10.1039/C7TB00704C.
    10.1039/C7TB00704C
  45. Teixeira, R.; Reis, R.L.; Pashkuleva, I.. "Influence of the sulfation degree of glycosaminoglycans on their multilayer assembly with poly-l-lysine". Colloids and Surfaces B: Biointerfaces 145 (2016): 567-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973130037&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2016.05.069
  46. Araújo, A.R.; Soares Da Costa, D.; Amorim, S.; Reis, R.L.; Pires, R.A.; Pashkuleva, I.. "Surfaces Mimicking Glycosaminoglycans Trigger Different Response of Stem Cells via Distinct Fibronectin Adsorption and Reorganization". ACS Applied Materials and Interfaces 8 42 (2016): 28428-28436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993994713&partnerID=MN8TOARS.
    10.1021/acsami.6b04472
  47. Ribeiro, V.P.; Almeida, L.R.; Martins, A.R.; Pashkuleva, I.; Marques, A.P.; Ribeiro, A.S.; Silva, C.J.; et al. "Influence of different surface modification treatments on silk biotextiles for tissue engineering applications". Journal of Biomedical Materials Research - Part B Applied Biomaterials 104 3 (2016): 496-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959905440&partnerID=MN8TOARS.
    10.1002/jbm.b.33400
  48. Yang, Y.; Köwitsch, A.; Ma, N.; Mäder, K.; Pashkuleva, I.; Reis, R.L.; Groth, T.. "Functionality of surface-coupled oxidised glycosaminoglycans towards fibroblast adhesion". Journal of Bioactive and Compatible Polymers 31 2 (2016): 191-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958527301&partnerID=MN8TOARS.
    10.1177/0883911515599999
  49. Francesko, A.; Fernandes, M.M.; Ivanova, K.; Amorim, S.; Reis, R.L.; Pashkuleva, I.; Mendoza, E.; et al. "Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters". Acta Biomaterialia 33 (2016): 203-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959554715&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.01.020
  50. Azevedo, H.S.; Pashkuleva, I.. "Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration". Advanced Drug Delivery Reviews 94 (2015): 63-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947612097&partnerID=MN8TOARS.
    10.1016/j.addr.2015.08.003
  51. Pires, R.A.; Abul-Haija, Y.M.; Costa, D.S.; Novoa-Carballal, R.; Reis, R.L.; Ulijn, R.V.; Pashkuleva, I.. "Controlling cancer cell fate using localized biocatalytic self-assembly of an aromatic carbohydrate amphiphile". Journal of the American Chemical Society 137 2 (2015): 576-579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921457793&partnerID=MN8TOARS.
    10.1021/ja5111893
  52. Silva, C.; Novoa-Carballal, R.; Reis, R.L.; Pashkuleva, I.. "Following the enzymatic digestion of chondroitin sulfate by a simple GPC analysis". Analytica Chimica Acta 885 (2015): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952874606&partnerID=MN8TOARS.
    10.1016/j.aca.2015.05.034
  53. Soares Da Costa, D.; Márquez-Posadas, M.D.C.; Araujo, A.R.; Yang, Y.; Merino, S.; Groth, T.; Reis, R.L.; Pashkuleva, I.. "Adhesion of adipose-derived mesenchymal stem cells to glycosaminoglycan surfaces with different protein patterns". ACS Applied Materials and Interfaces 7 18 (2015): 10034-10043. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929180016&partnerID=MN8TOARS.
    10.1021/acsami.5b02479
  54. Pires, Ricardo A.; Leonor, Isabel B.; Pashkuleva, Iva; Reis, Rui L.. "Research Highlights: Highlights from the latest articles in nanomedicine". Nanomedicine (London, England) 9 5 (2014): 573-6.
    10.2217/nnm.14.29
  55. Novoa-Carballal, R.; Silva, C.; Möller, S.; Schnabelrauch, M.; Reis, R.L.; Pashkuleva, I.. "Tunable nano-carriers from clicked glycosaminoglycan block copolymers". Journal of Materials Chemistry B 2 26 (2014): 4177-4184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902241807&partnerID=MN8TOARS.
    10.1039/c4tb00410h
  56. Francesko, A.; Soares Da Costa, D.; Reis, R.L.; Pashkuleva, I.; Tzanov, T.. "Functional biopolymer-based matrices for modulation of chronic wound enzyme activities". Acta Biomaterialia 9 2 (2013): 5216-5225. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872063730&partnerID=MN8TOARS.
    10.1016/j.actbio.2012.10.014
  57. Márquez-Posadas, M.C.; Ramiro, J.; Becher, J.; Yang, Y.; Köwitsch, A.; Pashkuleva, I.; Díez-Ahedo, R.; et al. "Surface microstructuring and protein patterning using hyaluronan derivatives". Microelectronic Engineering 106 (2013): 21-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874699272&partnerID=MN8TOARS.
    10.1016/j.mee.2013.01.039
  58. Amorim, S.; Pires, R.A.; Da Costa, D.S.; Reis, R.L.; Pashkuleva, I.. "Interactions between exogenous FGF-2 and sulfonic groups: In situ characterization and impact on the morphology of human adipose-derived stem cells". Langmuir 29 25 (2013): 7983-7992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879543962&partnerID=MN8TOARS.
    10.1021/la400871c
  59. Almeida, L.R.; Martins, A.R.; Fernandes, E.M.; Oliveira, M.B.; Correlo, V.M.; Pashkuleva, I.; Marques, A.P.; et al. "New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability". Acta Biomaterialia 9 9 (2013): 8167-8181. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880924437&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.05.019
  60. Altgärde, N.; Nilebäck, E.; De Battice, L.; Pashkuleva, I.; Reis, R.L.; Becher, J.; Möller, S.; Schnabelrauch, M.; Svedhem, S.. "Probing the biofunctionality of biotinylated hyaluronan and chondroitin sulfate by hyaluronidase degradation and aggrecan interaction". Acta Biomaterialia 9 9 (2013): 8158-8166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880924599&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.05.031
  61. Francesko, A.; Soares Da Costa, D.; Lisboa, P.; Reis, R.L.; Pashkuleva, I.; Tzanov, T.. "GAGs-thiolated chitosan assemblies for chronic wounds treatment: Control of enzyme activity and cell attachment". Journal of Materials Chemistry 22 37 (2012): 19438-19446. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865740021&partnerID=MN8TOARS.
    10.1039/c2jm31051a
  62. Da Costa, D.S.; Pires, R.A.; Frias, A.M.; Reis, R.L.; Pashkuleva, I.. "Sulfonic groups induce formation of filopodia in mesenchymal stem cells". Journal of Materials Chemistry 22 15 (2012): 7172-7178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858972552&partnerID=MN8TOARS.
    10.1039/c2jm15762d
  63. Gentile, P.; Mattioli-Belmonte, M.; Chiono, V.; Ferretti, C.; Baino, F.; Tonda-Turo, C.; Vitale-Brovarone, C.; et al. "Bioactive glass/polymer composite scaffolds mimicking bone tissue". Journal of Biomedical Materials Research - Part A 100 A 10 (2012): 2654-2667. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865655900&partnerID=MN8TOARS.
    10.1002/jbm.a.34205
  64. Balmayor, E.R.; Pashkuleva, I.; Frias, A.M.; Azevedo, H.S.; Reis, R.L.. "Synthesis and functionalization of superparamagnetic poly-e- caprolactone microparticles for the selective isolation of subpopulations of human adipose-derived stem cells". Journal of the Royal Society Interface 8 59 (2011): 896-905. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955743379&partnerID=MN8TOARS.
    10.1098/rsif.2010.0531
  65. Pashkuleva, I.; Marques, A.P.; Vaz, F.; Reis, R.L.. "Surface modification of starch based biomaterials by oxygen plasma or UV-irradiation". Journal of Materials Science: Materials in Medicine 21 1 (2010): 21-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-75049086153&partnerID=MN8TOARS.
    10.1007/s10856-009-3831-0
  66. López-Pérez, P.M.; Da Silva, R.M.P.; Sousa, R.A.; Pashkuleva, I.; Reis, R.L.. "Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: An in vitro study". Acta Biomaterialia 6 9 (2010): 3704-3712. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956749497&partnerID=MN8TOARS.
    10.1016/j.actbio.2010.03.008
  67. López-Pérez, P.M.; Da Silva, R.M.P.; Pashkuleva, I.; Román, J.S.; Reis, R.L.. "Temperature as a single on-off parameter controlling nanoparticles growing, stabilization and fast disentanglement". Advanced Materials 22 38 (2010): 4288-4292. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957905260&partnerID=MN8TOARS.
    10.1002/adma.201001717
  68. Alves, N.M.; Pashkuleva, I.; Reis, R.L.; Mano, J.F.. "Controlling cell behavior through the design of polymer surfaces". Small 6 20 (2010): 2208-2220. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349278497&partnerID=MN8TOARS.
    10.1002/smll.201000233
  69. Pashkuleva, I.; Reis, R.L.. "Sugars: Burden or biomaterials of the future?". Journal of Materials Chemistry 20 40 (2010): 8803-8818. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957791959&partnerID=MN8TOARS.
    10.1039/c0jm01605e
  70. Tuzlakoglu, K.; Pashkuleva, I.; Rodrigues, M.T.; Gomes, M.E.; Van Lenthe, G.H.; Müller, R.; Reis, R.L.. "A new route to produce starch-based fiber mesh scaffolds by wet spinning and subsequent surface modification as a way to improve cell attachment and proliferation". Journal of Biomedical Materials Research - Part A 92 1 (2010): 369-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549114019&partnerID=MN8TOARS.
    10.1002/jbm.a.32358
  71. López-Pérez, P.M.; Da Silva, R.M.P.; Serra, C.; Pashkuleva, I.; Reis, R.L.. "Surface phosphorylation of chitosan significantly improves osteoblast cell viability, attachment and proliferation". Journal of Materials Chemistry 20 3 (2010): 483-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-72949086588&partnerID=MN8TOARS.
    10.1039/b911854c
  72. López-Pérez, P.M.; Da Silva, R.M.P.; Pashkuleva, I.; Parra, F.; Reis, R.L.; San Roman, J.. "Hydrophobic-Electrostatic Balance Driving the LCST Offset Aggregation-Redissolution Behavior of N -Alkylacrylamide-Based Ionic Terpolymers". Langmuir 26 8 (2010): 5934-5941. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950933897&partnerID=MN8TOARS.
    10.1021/la903904t
  73. Pashkuleva, I.; López-Pérez, P.M.; Azevedo, H.S.; Reis, R.L.. "Highly porous and interconnected starch-based scaffolds: Production, characterization and surface modification". Materials Science and Engineering C 30 7 (2010): 981-989. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953958366&partnerID=MN8TOARS.
    10.1016/j.msec.2010.04.019
  74. Martins, A.; Pinho, E.D.; Faria, S.; Pashkuleva, I.; Marques, A.P.; Reis, R.L.; Neves, N.M.. "Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance". Small 5 10 (2009): 1195-1206. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649892067&partnerID=MN8TOARS.
    10.1002/smll.200801648
  75. Santos, M.I.; Pashkuleva, I.; Alves, C.M.; Gomes, M.E.; Fuchs, S.; Unger, R.E.; Reis, R.L.; Kirkpatrick, C.J.. "Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering". Journal of Materials Chemistry 19 24 (2009): 4091-4101. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149099423&partnerID=MN8TOARS.
    10.1039/b819089e
  76. Pashkuleva, I.; Azevedo, H.S.; Reis, R.L.. "Surface structural investigation of starch-based biomaterials". Macromolecular Bioscience 8 2 (2008): 210-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-41249096665&partnerID=MN8TOARS.
    10.1002/mabi.200700076
  77. Coutinho, D.F.; Pashkuleva, I.H.; Alves, C.M.; Marques, A.P.; Neves, N.M.; Reis, R.L.. "The effect of chitosan on the in vitro biological performance of chitosan-poly(butylene succinate) blends". Biomacromolecules 9 4 (2008): 1139-1145. http://www.scopus.com/inward/record.url?eid=2-s2.0-43149094168&partnerID=MN8TOARS.
    10.1021/bm701268s
  78. Silva, S.S.; Luna, S.M.; Gomes, M.E.; Benesch, J.; Pashkuleva, I.; Mano, J.F.; Reis, R.L.. "Plasma surface modification of chitosan membranes: Characterization and preliminary cell response studies". Macromolecular Bioscience 8 6 (2008): 568-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949117580&partnerID=MN8TOARS.
    10.1002/mabi.200700264
  79. Correlo, V.M.; Pinho, E.D.; Pashkuleva, I.; Bhattacharya, M.; Neves, N.M.; Reis, R.L.. "Water absorption and degradation characteristics of chitosan-based polyesters and hydroxyapatite composites". Macromolecular Bioscience 7 3 (2007): 354-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447344261&partnerID=MN8TOARS.
    10.1002/mabi.200600233
  80. López-Pérez, P.M.; Marques, A.P.; Silva, R.M.P.D.; Pashkuleva, I.; Reis, R.L.. "Effect of chitosan membrane surface modification via plasma induced polymerization on the adhesion of osteoblast-like cells". Journal of Materials Chemistry 17 38 (2007): 4064-4071. http://www.scopus.com/inward/record.url?eid=2-s2.0-34748835189&partnerID=MN8TOARS.
    10.1039/b707326g
  81. Pashkuleva, I.; Marques, A.P.; Vaz, F.; Reis, R.L.. "Surface modification of starch based blends using potassium permanganate-nitric acid system and its effect on the adhesion and proliferation of osteoblast-like cells". Journal of Materials Science: Materials in Medicine 16 1 (2005): 81-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-16444385371&partnerID=MN8TOARS.
    10.1007/s10856-005-6450-4
  82. Ivanova, D.; Vassileva, M.; Vassileva, N.; Pashkuleva, I.; Koleva, R.. "Stereoselective synthesis of new coumarin and N-methylcarbazole retinoic acid analogs". Journal of the Indian Chemical Society 80 6 (2003): 650-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041856525&partnerID=MN8TOARS.
  83. Dryanska, V.; Pashkuleva, I.; Angelov, V.. "A convenient synthesis of threo-4-amino-3, 4-diphenylbutanoic acid and its derivatives". Journal of Chemical Research - Part S 2 (2003): 89-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038643403&partnerID=MN8TOARS.
  84. Vassileva, E.; Apostolov, A.A.; Evstatiev, M.; Pashkuleva, I.; Friedrich, K.. "Effect of processing conditions on mechanical properties of pretreated gelatin samples". International Journal of Polymeric Materials and Polymeric Biomaterials 51 1-2 (2002): 103-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746332632&partnerID=MN8TOARS.
    10.1080/00914030213027
  85. Dryanska, V.; Pashkuleva, I.; Simova, S.; Angelova, S.. "Synthesis and stereochemistry of 1,2,4,5-tetraarylimidazolidines". Journal of Chemical Research - Part S 11 (2001): 457-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035684331&partnerID=MN8TOARS.
  86. Pashkuleva, I.; Dryanska, V.; Angelova, S.; Simova, S.. "Phase-transfer catalysed reactions of mono- and disubstituted N- (benzylidene)-benzylamines with cinnamic acid derivatives". Journal of Chemical Research - Part S 3 (2000): 103-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034023945&partnerID=MN8TOARS.
  87. Dryanska, V.; Pashkuleva, I.. "A simple and efficient synthesis of ¿-aminobutyric acid (GABA) derivatives". Organic Preparations and Procedures International 31 2 (1999): 232-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033243528&partnerID=MN8TOARS.
    10.1080/00304949909355722
  88. Dryanska, V.; Pashkuleva, I.; Tasheva, D.. "Preparation of ethyl esters of protected 3-aryl-2,3-diaminopropanoic acids by reaction of ethyl N-(diphenylmethylene)glycinate and azomethines". Synthetic Communications 27 11 (1997): 1849-1856. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031008215&partnerID=MN8TOARS.
    10.1080/00397919708006785
Capítulo de livro
  1. Costa, Rui R.; Reis, Rui L.; Pashkuleva, Iva. "Hydrogels formed by polyelectrolyte complexation". In Hydrogels for Tissue Engineering and Regenerative Medicine, 311-330. Elsevier, 2024.
    10.1016/b978-0-12-823948-3.00008-7
  2. Soares da Costa, Diana; Brito, Alexandra; Pashkuleva, Iva. Autor correspondente: Pashkuleva, Iva. "Supramolecular assemblies of glycopeptides as mimics of the extracellular matrix". In Multifunctional hydrogels for biomedical applications, editado por Pires, Ricardo A; Reis, Rui L.; Pashkuleva, Iva, 149-179. Weinheim, Alemanha: WILEY-VCH GmbH, 2022.
    Publicado
  3. Pashkuleva, Iva. "Hydrogel Nanomaterials for Cancer Diagnosis and Therapy". In Hydrogels Design, Synthesis and Application in Drug Delivery and Regenerative Medicine. 2018.
    Publicado
  4. Brito, Alexandra; Reis, Rui L.; Pires, Ricardo A.; Pashkuleva, Iva. "Sweet building blocks for self-assembling biomaterials with molecular recognition". In Self-assembling Biomaterials, 79-94. Elsevier, 2018.
    10.1016/b978-0-08-102015-9.00005-8
  5. Alves, N.M.; Pashkuleva, I.; Reis, R.L.; Mano, J.F.. "Polymer Patterns and Scaffolds for Biomedical Applications and Tissue Engineering". In Generating Micro- and Nanopatterns on Polymeric Materials, 291-302. 2011.
    Publicado • 10.1002/9783527633449.ch13
  6. Pashkuleva, I.; López-Pérez, P.M.; Reis, R.L.. "Surface modification of natural-based biomedical polymers". In Natural-Based Polymers for Biomedical Applications, 165-192. 2008.
    Publicado • 10.1533/9781845694814.2.165
Resumo em conferência
  1. Pashkuleva, Iva. "Co-assembly of peptide and carbohydrate amphiphiles to generate proteoglycan mimics". Trabalho apresentado em 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Publicado
  2. Pashkuleva, Iva. "Short carbohydrate amphiphiles as smart therapeutics targeting cancer". Trabalho apresentado em 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Publicado
  3. Pashkuleva, Iva. "Hyaluronan density influences adhesion, morphology and migration of cancer cells". Trabalho apresentado em 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, 2018.
    Publicado
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/09 - Atual Development of 3D in vitro models of glioblastoma
Coorientador
Universidade do Minho, Portugal
2023/09 - Atual Influence of micro and nanoplastics on blood cells
Coorientador
Universidade do Minho, Portugal
2023/01 - Atual Layer-by-layer therapeutic constructs for the treatment of breast cancer
Coorientador
Biomedical Engineering (Mestrado)
Universidade do Minho, Portugal
2020/01 - Atual Bioadhesive materials for spinal cord regeneration
Coorientador
Universidade do Minho, Portugal
2021/11 - 2023/12 Bioadhesive hydrogels based on hyaluronic acid for spinal cord regeneration
Coorientador
Biomedical Engineering (Mestrado)
Universidade do Minho, Portugal
2016 - 2023/10 Block copolymer nanopatterns for biomedical applications
Orientador
Tissue engineering, regenerative medicine and stem cells (Doutoramento)
Universidade do Minho, Portugal
2021/11 - 2023/01 Inorganic-templated and polymeric layer-by-layer nanocapsules for the treatment of cancer
Coorientador
Biomedical Engineering (Mestrado)
2017 - 2022/07 NANOGLYCAN: Glycotools for elucidating molecular and cellular interaction of glycans in vitro
Orientador
Universidade do Minho, Portugal
2015 - 2020 Synthesis of carbohydrate based supramolecular hydrogels for tissue engineering
Orientador
Universidade do Minho, Portugal
2014 - 2018 Development and characterisation of hybrid polyelectrolyte fibers
Orientador
Universidade do Minho, Portugal
2008 - 2012 Multifunctional biopolymer-based materials for modulating the activities of chronic wound enzymes
Coorientador
Universitat Politècnica de Catalunya, Espanha
2005 - 2010 Some hints on using surface phenomena for the design and performance optimisation of distinct biomedical devices
Orientador
Universidade do Minho, Portugal
1999 - 2001 A convenient synthesis of threo-4-amino-3,4-diphenylbutanoic acid and its derivatives
Coorientador
Sofiski universitet Sveti Kliment Ohridski, Bulgária

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023/09/04 - 2023/09/08 33rd Annual Conference of the European Society for Biomaterials (ESB 2023) (2023/09/04 - 2023/09/08)
Conferência (Membro da Comissão Organizadora)
2014/01 - 2014/10 Top-down fabrication and nanocharacterisation techniques to develop nanosystems for biomedical applications, 2nd Workshop within EU POLARIS project (2014/10/20 - 2014/10/22)
Oficina (workshop) (Membro da Comissão Organizadora)
2013/01 - 2013/10 Nanosystems for Medicine: Fundamentals, synthesis and applications, 1st Workshop under EU POLARIS project (2013/10/07 - 2013/10/09)
Oficina (workshop) (Membro da Comissão Organizadora)
2009/01 - 2009/05 ESBP 2009 - 5th European Symposium on Biopolymers “Design, Production & Applications of Biopolymers in Tissue Engineering, Regenerative Medicine, Drug Delivery, Biotechnology and Nanomedicine (2009/05/09 - 2009/05/12)
Simpósio (Membro da Comissão Organizadora)
2007/06 - 2008/06 TERMIS 2008 - The European Chapter of Tissue Engineering and Regenerative Medicine International Society Meeting (2008/06/22 - 2008/06/26)
Conferência (Membro da Comissão Organizadora)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2023/03/19 - 2023/03/24 Invited talk: Enhancing the selectivity and functionality of supramolecular biomaterials by glycan incorporation, Aveiro, Portugal
Conferência
SupraLife first school on functional supramolecular polymeric biomaterials
Universidade de Aveiro, Portugal
2023/03/07 - 2023/03/07 Invited talk: Supramolecular chemistry and carbohydrates for targeted cancer therapies, Sofia, Bulgaria
Outro
EXTREME: Excellence in colloid and interface research & innovations for better quality of life
Sofiski universitet Sveti Kliment Ohridski, Bulgária
2023/01/16 - 2023/01/18 Plenary lecture: Hyaluronan-based materials for understanding and targeting breast cancer associated CD44 and RHAMM receptors, Lisbon, Portugal
Conferência
14th Meeting of the Glycosides group GLUPOR
Universidade Nova de Lisboa, Portugal
2021/06 - 2021/06 Invited talk: Perturbation of hyaluronan functions toward understanding and treatment of breast cancer, Braga, Portugal
Conferência
3th Forecast Workshop on Hallmarks in cancer and the development of diagnostic tools
2020/01 - 2020/01 Invited talk: Design of glycome-inspired bioinstructive materials, Perugia, Italy
Oficina (workshop)
Winter School on Biotechnology
Università degli Studi di Perugia, Itália
2019/12 - 2019/12 Invited talk: Carbohydrate nanotools for selective inhibition of cancer metabolism, Braga, Portugal
Simpósio
First symposium in Biophysics and Bionanosystems
Universidade do Minho, Portugal
2018/08 - 2018/08 Invited talk: Glycans as multifunctional building blocks for biomaterials, NY, USA
Seminário
Seminar series of the Nanoscience initiative at the Advanced Science Research Center
City University of New York, Estados Unidos
2018/07 - 2018/07 Invited talk: Exploring glycan-protein interactions in biomaterials design, Lisbon, Portugal
Encontro
Bioscience Analysis Tools Meeting, Lisbon, Portugal
2017/09 - 2017/09 Invited talk: Engineering supramolecular functional biomaterials from glycans, Aveiro, Portugal
Encontro
12th Meeting of the Glycosides group GLUPOR
2017/05 - 2017/05 Invited talk: Supramolecular glyco-approaches for biomedical applications, Porto, Portugal MSc programme on “Biointerfaces and Cell Behaviour”
Universidade Católica Portuguesa Centro Regional do Porto, Portugal
2016/11 - 2016/11 Invited talk: Sulfated glycosaminoglycans: biosynthesis, bioactivities and associated diseases, Guimaraes, Portugal
Oficina (workshop)
Chem2Nature first School on “Chemical Strategies for the modification of natural origin materials for biomedical applications”
2016/05 - 2016/05 Invited talk: Glycan building blocks for supramolecular biomaterials, Braga, Portugal
Seminário
Ciência Falada
Universidade do Minho, Portugal
2016/04 - 2016/04 Invited talk: Supramolecular nanobioparticles from glycosaminoglycans: designs, synthesis and characterization, Lisbon, Portugal
Oficina (workshop)
Trends in Nanobioparticles Characterization
2013/07 - 2013/07 Invited talk: Sweet talk on some glyco-approaches for biochemical applications, Stuttgart, Germany
Seminário
Max-Planck-Institut für Intelligente Systeme Physical Intelligence Department, Alemanha

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2024/09 The impact of preservation strategies on tissue engineering constructs: streamlining future clinical application
Arguente
Sara Cristina Freitas Ribeiro (Doutoramento)
Universidade do Minho, Portugal
2024/06 Hybrid metal-organic nanoparticles for antimicrobial applications
Presidente do júri
Guillem Ferreres (Doutoramento)
Universitat Politécnica de Catalunya - Campus de Terrassa, Espanha
2024/01 Molecular imprinting technologies for growth factor sequestration and control of stem cell fate in tendon regeneration
Arguente
Simão Pedro Barbosa Teixeira (Doutoramento)
Universidade do Minho, Portugal
2023/10 Block Copolymer Nanopatterns for Biomedical Applications
Orientador
Raúl Fontelo Rodríguez (Doutoramento)
Universidade do Minho, Portugal
2023/06 Glycotools for elucidating molecular and cellular interactions of glycans in vitro
Orientador
Ana Margarida de Moura Pereira e Ferreira Carvalho (Doutoramento)
Universidade do Minho, Portugal
2022/03/10 Nanomaterials for controlling bacterial pathogens and resistance occurrence
Presidente do júri
Aleksandra Ivanova (Doutoramento)
Universitat Politècnica de Catalunya, Espanha
2021/04/13 Gellan-gum based hydrogels for tissue engineering applications
Arguente
Sílvia Cristina Araújo Vieira (Doutoramento)
Universidade do Minho, Portugal
2020/12 Strategies towards the recreation of a hair follicle regenerative microenvironment
Arguente
Carla Patricia Martins Abreu (Doutoramento)
Universidade do Minho, Portugal
2020/07 Fucoidan-based strategies envisioning antitumor therapies
Arguente
Ana Catarina Freitas Salazar de Oliveira (Doutoramento)
Universidade do Minho, Portugal
2020/07 Supramolecular assembly of carbohydrate amphiphiles for biomedical applications
Orientador
Alexandra Manuela Fernandes Brito (Doutoramento)
Universidade do Minho, Portugal
2020/07 Micro/nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration
Arguente
Bárbara Bruna da Silva Mendes (Doutoramento)
Universidade do Minho, Portugal
2019/10 Uncovering heparan sulfate proteoglycans biosynthetic pathways and functional relevance in gastric cancer
Arguente principal
Catarina Marques Goncalves (Mestrado)
Universidade do Porto, Portugal
2019/03 Biomimetic functionalisation of hierarchical scaffolds for tendon tissue engineering
Arguente principal
Helena Maria Coelho de Almeida (Mestrado)
Universidade do Minho, Portugal
2018/03 Tailoring Injectable hyaluronic acid/cellulose nanocrystal hydrogels for soft tissue regeneration
Arguente principal
Cristiana Filipa Ribeiro e Silva (Mestrado)
Universidade do Minho, Portugal
2015 Exploring hyaluronic acid enriched with platelet lysates as a promising injectable and cryostable hydrogel for regenerative medicine applications
Arguente principal
Lisete dos Santos Neves (Mestrado)
Universidade do Minho, Portugal
2014/11 Graphene nanoribbons for multilayer films based on natural polymers
Arguente principal
Helena Cristina Lopes Rocha (Mestrado)
Universidade do Minho, Portugal
2014 Novel 3D scaffolds modified with nanostructured polymeric coatings or micro/nanofibers for tissue engineering applications
Arguente
Sara Maria Marques de Oliveira (Doutoramento)
Universidade do Minho, Portugal
2013/12 Bioactive membranes for bone regeneration
Arguente
Sofia Gloria Ferreira Caridade (Doutoramento)
Universidade do Minho, Portugal
2013/12 Immobilization of specific growth factors from platelet lysate at the surface of electrospun nanofibers for tissue engineering applications
Arguente principal
Ana Catarina Freitas Salazar de Oliveira (Mestrado)
Universidade do Minho, Portugal
2012/12 Development of multifunctional biopolymeric materials for treatment of decubitus ulcers
Arguente principal
Guillem Rocasalbas Lozano (Doutoramento)
Universitat Politècnica de Catalunya, Espanha
2012/12 Multifunctional biopolymer-based materials for modulating the activities of chronic wound enzymes
Arguente principal
Antonio Francesko (Doutoramento)
Universitat Politècnica de Catalunya, Espanha
2011/12 Cells behavior on superhydrophobic surfaces with different topographies
Arguente principal
Bianca Lourenço (Mestrado)
Universidade do Minho, Portugal
2011/12 Biotechnical and biomimetic approaches for coating of textile surfaces and enhancement of cleaning formulation
Arguente principal
Carlos Diaz Blanco (Doutoramento)
Universitat Politècnica de Catalunya, Espanha
2010/11 Patterned superhydrophobic surfaces as a new platform for high-throughput evaluation of biomaterials interactions with proteins and cells
Arguente principal
Ana Isabel Morais Neto (Mestrado)
Universidade do Minho, Portugal
2010/01 Some hints on using surface phenomena for the design and performance optimization of distinct biomedical devices
Orientador
Paula Matilde López Pérez (Doutoramento)
Universidade do Minho, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2016/04 - Atual 5th Portuguese Young Chemists Meeting (5th PYCheM)
2023/09/04 - 2023/09/08 ESB2023: 33rd Annual Conference of the European Society for Biomaterials Davos, Switzerland
2023/01/16 - 2023/01/18 GLUPOR 14: 14th International Meeting of the Portuguese Carbohydrate Group NOVA School of Science and Technology, NOVA University of Lisbon, Caparica, Portugal
2019/09/03 - 2019/09/05 GLUPOR 13: 13th International Meeting of the Portuguese Carbohydrate Group Universidade do Porto

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual Cells (2073-4409) MDPI
2019 - Atual Molecules (1420-3049) MDPI AG
2016 - Atual Carbohydrate Polymers (0144-8617) Elsevier
2011 - Atual Journal of Tissue Engineering and Regenerative Medicine (1932-7005) Wiley (John Wiley & Sons)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2023 - Atual AXA Research Fund
Avaliador
2022 - Atual Czech Scientific Foundation
Avaliador
2021 - Atual Horizon Marie Sklodowska-Curie actions, Chemistry Panel: Evaluation of individual fellowships
Avaliador
2020 - Atual H2020 FET OPEN
Avaliador
2015 - 2024 Swiss National Science Foundation: Evaluation of Individual fellowships
Avaliador
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Suiça Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2018 - 2020 ERA-NET: evaluations of proposals
Avaliador
European Union
2015 - 2020 H2020 Marie Sklodowska-Curie actions, Chemistry Panel: Evaluation of individual fellowships
Avaliador
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2015 - 2016 EMPA, Switzerland (co-fund programme): evaluation of individual fellowships
Avaliador
Empa Materials Science and Technology, Suiça Empa Materials Science and Technology

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2015 - Atual Biomaterials module of the Doctoral Programme in Tissue Engineering and Regenerative Medicine (TERM) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Minho, Portugal

Membro de associação

Nome da associação Tipo de participação
2010/01 - Atual Associação Nacional de Investigadores em Ciência e Tecnologia Founding member
2010 - Atual Royal Society of Chemistry
2010 - Atual American Chemical Society

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2018 - Atual General Council of I3Bs, University of Minho
Membro
Universidade do Minho, Portugal
2018 - 2023 Scientific Council of I3Bs, University of Minho
Membro
Universidade do Minho, Portugal
2020/09 - 2022/08 Steering Committee of the Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells
Membro
2017 - 2018 General Council of Department of Polymer Engineering, University of Minho, Portugal
Membro
Universidade do Minho, Portugal
2012 - 2015 General Council of Department of Polymer Engineering, University of Minho, Portugal
Membro
Universidade do Minho, Portugal

Tutoria

Tópico Nome do aluno
2023 - Atual Supramolecular materials targeting cancer Alexandra Brito
2019 - Atual Tackling Tumor Heterogeneity Using Biomaterial-Based Multifunctional Nanocarriers Against Cancer Rui Costa
2019 - Atual Influence of the GAGs molecular weight and sulfation degree on cells behaviour Diana Soares da Costa
2018/11 - 2019/03 Combined layer by layer/liposome devices for sustained drug release Vicente Domínguez Arca
2016 - 2019 Self-healing hydrogels based on glycosaminoglycans Rui Costa
2009 - 2019 Influence of the GAGs molecular weight and sulfation degree on stem cells cytoskeleton organisation Diana Soares da Costa
2018/03 - 2018/11 Effect of stereochemistry on the assembly and properties of supramolecular structures made of short aromatic carbohydrate amphiphiles YuTing Gao
2018/01 - 2018/05 Bioactivity of hydroxyapatite nanorods Ramon Rial Silva
2013 - 2018 Novel star and brush polysaccharide architectures as protein nanocarriers Ramon Novoa-Carballal
2015 - 2017 Combining aloe compounds with natural polymers at micro/nano scale for cancer treatment Simone Silva
2014 - 2015 Sulfatases as tools in the design and synthesis of glycan biomaterials Klaus Neumuller
2014 - 2015 Synthesis of glycan amphiphiles as hydrogelators Raquel Teixeira
2013 - 2014 Sulfated polysaccharides as 3D matrixes for cell encapsulation Rami Mhanna
2011 - 2013 Synthesis and characterisation of sugar decoys for metabolic glycoengineering Nevena Petkova
2010 - 2011 Understanding GAG molecular interactions using different spatial environments (homogeneous and nano-structured surfaces) Patricia Lisboa