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Degree in Chemical Engineering from the Polytechnic Institute of Viana do Castelo. Master's degree in Medicinal Chemistry from the University of Minho. PhD in Chemistry from the University of Évora. Synthesis of compounds with potential anti-tumor and / or anti-angiogenic activities (eg thienopyridines, thienopyrimidines, thienopyrazines, thienoquinolines, thienoquinoxalines ...); Synthesis of compounds with potential Alzheimer's and / or Parkinson's activity (eg Isoquinolinones, Azepinones, Dibenzodiazepines, Acridines ...); Mechanistic studies for the formation of different compounds using NHO; New heterocyclic compounds for dual activity, anti-tumoral and anti-multidrug resistence Characterization of the compounds by NMR spectrometry, including heteronuclear homo and bidimensional correlations, COZY, HSQC and HMBC. Analysis of purity of the compounds by HPLC; Development of a new generation of hydrogels based on natural polymers combined with catechol groups, in particular hyaluronic acid and chitosan that have demonstrated adequate properties such as biocompatibility for several biomedical applications; Characterization of the hydrogel by chemical and physical properties: FTIR, NMR, SEM coupled with EDS, AFM, micro-CT, rheology, swelling and compressive experiments and bioactivity studies.
Identificação

Identificação pessoal

Nome completo
Daniela Peixoto

Nomes de citação

  • Peixoto, Daniela

Identificadores de autor

Ciência ID
B915-4019-2941
ORCID iD
0000-0001-8319-6894

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2013/02 - 2015/12/18
Concluído
Chemistry (Doutoramento)
Universidade de Évora Centro de Química de Évora, Portugal
"Catalytic intramolecular arylation of imines and analogues - Potential drugs for neurodegenerative diseases" (TESE/DISSERTAÇÃO)
2009/09 - 2011/12/05
Concluído
Mestrado Química Medicinal (Mestrado)
Universidade do Minho, Portugal
"Synthesis of new thienopyridine derivatives as antitumor and/or antiangiogenic potentials" (TESE/DISSERTAÇÃO)
2009
Concluído
Chemical Engineering (Licenciatura)
Instituto Politécnico de Viana do Castelo, Portugal
Percurso profissional

Ciência

2019/06/05 - Atual Investigador Contratado (Investigação)
Biomaterials Biodegradables and Biomimetics, Portugal
2018/12/03 - 2019/05/31 Investigador Contratado (Investigação)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016/02/01 - 2018/11/30 Pós-doutorado (Investigação)
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Outros

2013/02/01 - 2015/06/30 doctoral fellow in project ALENT-07-0224-FEDER-001743
Universidade de Évora Centro de Química de Évora, Portugal
2011/09/01 - 2012/10/31 research fellow in project PTDC/QUI-QUI/111060/2009
Universidade do Minho Centro de Química, Portugal
Projetos

Projeto

Designação Financiadores
2018 - 2019/05/31 Discovery of inhibitors of protein-protein interaction of p53
PTDC/Qui-QOR/29664/2017
Investigador
2016 - 2018/11/30 Developments in the reactivity of 2-methylimidazolium salts
LAQV/BPD/030/2016
Bolseiro de Pós-Doutoramento
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2018 - 2018/08/31 Synthesis of API (Active Pharmaceutical Ingredient) and development of synthetic routes to apply in large-scale.
Nova.ID.FCT
Bolseiro de Pós-Doutoramento
2016 - 2016/07/31 Gulbenkian Qualificação das Novas Gerações
137831 STEREO+
Bolseiro de Pós-Doutoramento
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2013 - 2015/12/18 INMALFARM- Inovação Molecular e descoberta de Fármacos
ALENT-07-0224-FEDER-001743 ALENT-07-0224-FEDER-001743
Bolseiro de Doutoramento
Universidade de Évora Centro de Química de Évora, Portugal
2011 - 2012/10/31 Novel antitumor and / or antiangiogenic heterocyclic compounds: synthesis, molecular modeling, enzyme inhibition screening and studies on tumor and endothelial cell lines with membrane tyrosine kinase receptors as targets
PTDC/QUI-QUI/111060/2009
Bolseiro de Investigação
Universidade do Minho Centro de Química, Portugal

Outro

Designação Financiadores
2010 - 2012/12/05 Synthesis of new thienopyridine derivatives as antitumor and/or antiangiogenic potentials
CQ-UM
Bolseiro de Mestrado
Produções

Publicações

Artigo em conferência
  1. Peixoto, Daniela; Ian Rodrigues; Ricardo Teixeira; Sofia Cavaco; Vasco D. B. Bonifacio; Yuri Binev; Florbela Pereira; Ana Lobo; João Aires-de-Sousa. "2D Spatial Audio in a Molecular Navigator/Editor for Blind and Visually Impaired Users". Trabalho apresentado em DAFx 2017 - Proceedings of the 20th International Conference on Digital Audio Effects 2017, Pages 360-366, Edinburgh, 2017.
    Publicado
Artigo em revista
  1. Roma-Rodrigues, Catarina; Malta, Gabriela; Peixoto, Daniela; Ferreira, Luísa M.; Baptista, Pedro V.; Fernandes, Alexandra R.; Branco, Paula S.. "Synthesis of New Hetero-Arylidene-9(10H)-Anthrone Derivatives and Their Biological Evaluation". Bioorganic Chemistry (2020): 103849. http://dx.doi.org/10.1016/j.bioorg.2020.103849.
    10.1016/j.bioorg.2020.103849
  2. Peixoto, Daniela; Malta, Gabriela; Cruz, Hugo; Barroso, Sónia; Carvalho, Ana Luísa; Ferreira, Luísa M.; Branco, Paula S.. "N-Heterocyclic Olefin Catalysis for the Ring Opening of Cyclic Amidine Compounds: A Pathway to the Synthesis of e-Caprolactam- and ¿-Lactam-Derived Amines". The Journal of Organic Chemistry 84 7 (2019): 3793-3800. http://dx.doi.org/10.1021/acs.joc.8b02823.
    10.1021/acs.joc.8b02823
  3. Peixoto, Daniela; Ferreira, Elisabete P.; Lourenço, Ana M.; Johnson, Jordan L.; Lobo, Ana M.; Polavarapu, Prasad L.. "(R )-Metacycloprodigiosin-HCl: Chiroptical properties and structure". Chirality 30 7 (2018): 932-942. http://dx.doi.org/10.1002/chir.22867.
    10.1002/chir.22867
  4. Daniela Peixoto; Margarida Figueiredo; Gabriela Malta; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes; Sónia Barroso; et al. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H )-Anthrone". European Journal of Organic Chemistry 2018 4 (2018): 545-549. https://doi.org/10.1002/ejoc.201701500.
    10.1002/ejoc.201701500
  5. Binev, Yuri; Peixoto, Daniela; Pereira, Florbela; Rodrigues, Ian; Cavaco, Sofia; Lobo, Ana M; Aires-de-Sousa, João. "NavMol 3.0: enabling the representation of metabolic reactions by blind users". Bioinformatics 34 1 (2017): 120-121. http://dx.doi.org/10.1093/bioinformatics/btx556.
    10.1093/bioinformatics/btx556
  6. Peixoto, Daniela; Figueiredo, Margarida; Gawande, Manoj B.; Corvo, Marta C.; Vanhoenacker, Gerd; Afonso, Carlos A. M.; Ferreira, Luisa M.; Branco, Paula S.. "Developments in the Reactivity of 2-Methylimidazolium Salts". The Journal of Organic Chemistry 82 12 (2017): 6232-6241. http://dx.doi.org/10.1021/acs.joc.7b00807.
    10.1021/acs.joc.7b00807
  7. Bacalhau, Patrícia; San Juan, Amor A.; Marques, Carolina S.; Peixoto, Daniela; Goth, Albertino; Guarda, Cátia; Silva, Mara; et al. "New cholinesterase inhibitors for Alzheimer’s disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives". Bioorganic Chemistry 67 (2016): 1-8. http://dx.doi.org/10.1016/j.bioorg.2016.05.004.
    10.1016/j.bioorg.2016.05.004
  8. Bacalhau, P.; San Juan, A.A.; Marques, C.S.; Peixoto, D.; Goth, A.; Guarda, C.; Silva, M.; et al. "New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives". Bioorganic Chemistry 67 (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988982023&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.05.004
  9. Machado, V.A.; Peixoto, D.; Queiroz, M.J.; Soares, R.. "Antiangiogenic 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas Inhibit MCF-7 and MDA-MB-231 Human Breast Cancer Cell Lines Through PI3K/Akt and MAPK/Erk Pathways". Journal of Cellular Biochemistry (2016): 2791-2799. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991276466&partnerID=MN8TOARS.
    10.1002/jcb.25580
  10. Marques, C.S.; Peixoto, D.; Burke, A.J.. "Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives". RSC Advances 5 26 (2015): 20108-20114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923875817&partnerID=MN8TOARS.
    10.1039/c5ra00404g
  11. Peixoto, D.; Locati, A.; Marques, C.S.; Goth, A.; Ramalho, J.P.P.; Burke, A.J.. "A catalytic route to dibenzodiazepines involving Buchwald-Hartwig coupling: Reaction scope and mechanistic consideration". RSC Advances 5 121 (2015): 99990-99999. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948440612&partnerID=MN8TOARS.
    10.1039/c5ra19599c
  12. Machado, V.A.; Peixoto, D.; Costa, R.; Froufe, H.J.C.; Calhelha, R.C.; Abreu, R.M.V.; Ferreira, I.C.F.R.; Soares, R.; Queiroz, M.-J.R.P.. "Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors". Bioorganic and Medicinal Chemistry 23 19 (2015): 6497-6509. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942191894&partnerID=MN8TOARS.
    10.1016/j.bmc.2015.08.010
  13. Calhelha, R.C.; Peixoto, D.; Vilas Boas, M.; Queiroz, M.-J.R.P.; Ferreira, I.C.F.R.. "Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: Radical scavenging activity, lipid peroxidation inhibition and redox profile". Journal of Enzyme Inhibition and Medicinal Chemistry 29 3 (2014): 311-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896923154&partnerID=MN8TOARS.
    10.3109/14756366.2013.777718
  14. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Lima, R.T.; Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.023
  15. Begouin, A.; Peixoto, D.; Queiroz, M.-J.R.P.. "Regiocontrolled SNAr reaction on 2,3-dihalopyridines with NaSMe to obtain bromo(methylthio)pyridines as key precursors of 3-halo-2-(hetero) arylthieno[2,3- b ]pyridines and thieno[3,2- b ]pyridines". Synthesis (Germany) 45 11 (2013): 1489-1496. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878128379&partnerID=MN8TOARS.
    10.1055/s-0033-1338442
  16. Queiroz, M.-J.R.P.; Peixoto, D.; Rodrigues, A.R.O.; Mendes, P.M.F.; Costa, C.N.C.; Coutinho, P.J.G.; Castanheira, E.M.S.. "New 1,3-diarylureas linked by CC Suzuki coupling to the methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate moiety: Synthesis and fluorescence studies in solution and in lipid membranes". Journal of Photochemistry and Photobiology A: Chemistry 255 (2013): 27-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874398237&partnerID=MN8TOARS.
    10.1016/j.jphotochem.2013.01.006
  17. Soares, P.; Costa, R.; Froufe, H.J.C.; Calhelha, R.C.; Peixoto, D.; Ferreira, I.C.F.R.; Abreu, R.M.V.; Soares, R.; Queiroz, M.-J.R.P.. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880883258&partnerID=MN8TOARS.
    10.1155/2013/154856
  18. Peixoto, D.; Begouin, A.; Queiroz, M.-J.R.P.. "Synthesis of 2-(hetero)arylthieno[2,3-b] or [3,2-b]pyridines from 2,3-dihalopyridines, (hetero)arylalkynes, and Na 2S. Further functionalizations". Tetrahedron 68 35 (2012): 7082-7094. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863817911&partnerID=MN8TOARS.
    10.1016/j.tet.2012.06.057
  19. Calhelha, R.C.; Ferreira, I.C.F.R.; Peixoto, D.; Abreu, R.M.V.; Vale-Silva, L.A.; Pinto, E.; Lima, R.T.; et al. "Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells". Molecules 17 4 (2012): 3834-3843. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860247243&partnerID=MN8TOARS.
    10.3390/molecules17043834
  20. Queiroz, M.-J.R.P.; Dias, S.; Peixoto, D.; Rodrigues, A.R.O.; Oliveira, A.D.S.; Coutinho, P.J.G.; Vale-Silva, L.A.; Pinto, E.; Castanheira, E.M.S.. "New potential antitumoral di(hetero)arylether derivatives in the thieno[3,2-b]pyridine series: Synthesis and fluorescence studies in solution and in nanoliposomes". Journal of Photochemistry and Photobiology A: Chemistry 238 (2012): 71-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860992423&partnerID=MN8TOARS.
    10.1016/j.jphotochem.2012.04.007
Poster em conferência
  1. C. Correia; Peixoto, Daniela; A. C. Vale; N. M. Alves. "Production and characterization of tissue adhesives for Gastrointestinal repair". Trabalho apresentado em Term Stem 2019, Braga, Portugal, 2019.
  2. C. Correia; V. C. Costa; Peixoto, Daniela; A. C. Vale; N. M. Alves. "Production of tissue adhesives based on marine-derived materials for Gastrointestinal repair". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, Porto, Portugal, 2019.
  3. Peixoto, Daniela; Rippel R.; Lourenço A.; Ferreira L.; Branco P. S.; Antunes R.; Carvalho L.. "A straightforward approach to olodaterol synthesis applying the asymmetric Henry reaction". Trabalho apresentado em IsySyCat 2019, Évora, Portugal, 2019.
  4. Peixoto, Daniela; Rita Jesus; Maria Viana; Alice S. Pereira; Luisa M. Ferreira; Paula S. Branco. "New e-Caprolactam and ¿-Lactam-Derived Amines as acetylcholinesterase inhibitors". Trabalho apresentado em XXVI Encontro Nacional, Sociedade Portuguesa de Química, Porto, 2019.
  5. Peixoto, Daniela; Margarida Figueiredo; Gabriela Malta; Luisa M. Ferreira; Paula S. Branco. "Synthesis and mechanistic studies of hetero arylidene-9(10H)-anthrone". Trabalho apresentado em 12 ENQO, Coimbra, 2018.
  6. Peixoto, Daniela; Luisa M. Ferreira; Paula S. Branco. "Pathway to the synthesis of 1,3-diamines a high value added compound". Trabalho apresentado em XXV Encontro Nacional, Sociedade Portuguesa de Química, Lisboa., 2017.
  7. Peixoto, Daniela; Yuri Binev; Ian Rodrigues; Ricardo Teixeira; Rui Fartaria; Florbela Pereira; Vasco Bonifácio; et al. "NavMol 2.2s – A software for navigation and editing of molecular formulas for blinds and visually impaired users". Trabalho apresentado em Ciência 2016, Lisboa., 2016.
  8. Peixoto, Daniela; Abel Locati; Carolina S. Marques; Albertino Goth; J.P. Prates Ramalho; Anthony J. Burke. "A Novel Catalytic Route to Dibenzodiazepines involving Buchwald-Hartwig Coupling". Trabalho apresentado em IsySyCat 2015, Évora, Portugal, 2015.
  9. Carolina S. Marques; Peixoto, Daniela; Anthony J. Burke. "Synthesis of a Library of Isoquinolinones and Azepinones Derivatives using a Metal-Catalyzed Intramolecular Cyclization Reaction as the kep step". Trabalho apresentado em IsySyCat 2015, Évora, Portugal, 2015.
  10. Bacalhau, P.; San Juan A.; Marques C.; Peixoto, Daniela; Burke, A.J.; Caldeira A.; Martins M. R. "The role of cholinesterases in Alzheimer’s disease: screening of target compounds". Trabalho apresentado em The 12th International conference on Alzheimers’s & Parkinson’s diseases. AD/PDTM, Nice, France, 2015.
  11. Sílvia Arantes; Mara Silva; Carolina Marques; Peixoto, Daniela; M. Rosário Martins; Anthony J. Burke; Ana Teresa Caldeira. "Antioxidant and antimicrobial activities of arylamides-acetals derivatives: potencial drugs for neurodegenerative diseases". Trabalho apresentado em XVIII Congresso the Portuguese Biochemical Society, Coimbra, Portugal, 2014.
  12. Abel Locati; Peixoto, Daniela; Carolina S. Marques; J.P. Prates Ramalho; Anthony J. Burke. "Computational study for the palladium-catalyzed dibenzodiazepine synthesis". Trabalho apresentado em CRC-SU Joint International Symposium on Chemical Theory for Complex Systems”, Stockholm, Sweden, 2014.
  13. Cátia Guarda; Peixoto, Daniela; Carolina S. Marques; Paulo J. Mendes; Anthony J. Burke. "Catalytic Borylation/Intramolecular Arylation as a Novel Approach to Rasagline Derivatives". Trabalho apresentado em EFMC-YMCS, 1st EFMC-YOUNG Medicinal Chemist Symposium, Lisbon, Portugal, 2014.
  14. Anthony J. Burke; Carolina S. Marques; Peixoto, Daniela; A. Mourato; Amor San Juan; Hugo Viana; João Mendes; Cátia Guarda; Sílvia Fernandes. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". Trabalho apresentado em EFMC-ISMC 2014 XXIII International Symposium on Medicinal Chemistry, Lisbon, Portugal;, 2014.
  15. Peixoto, Daniela; Carolina S. Marques; Cátia Guarda; Paulo J. Mendes; Anthony J. Burke. "Versatile Innovative Metal Catalyzed Couplings - Modular Approach to Rasagiline Analogues". Trabalho apresentado em 15th Tetrahedron Symposium, Challenges in Bioorganic & Organic Chemistry, London, United Kingdom., 2014.
  16. Peixoto, Daniela; A. Locati; A. Mourato; C.S. Marques; P.J.G. Mendes; J.P. Ramalho; A.J. Burke. "CIA -Catalytic Intramolecular Arylation - Studies at Controlling the Ring Size". Trabalho apresentado em 15th Tetrahedron Symposium, Challenges in Bioorganic & Organic Chemistry, London, United Kingdom., 2014.
  17. Peixoto, Daniela; Carolina S. Marques; Paulo J. Mendes; Anthony J. Burke. "BoImAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A New Synthetic Approach to Promising Alzheimer and Parkinson Drugs". Trabalho apresentado em 10ENQO-1SLB, Faculdade de Farmácia, Universidade de Lisboa-Portugal, 2013.
  18. Mara Silva; Peixoto, Daniela; M. R.Martins; A-J.Burke; A.T. Caldeira. "Antioxidant and Antifungival activities of halogenated arlamide-acetals: patential drugs for neurodegenerative diseades". Trabalho apresentado em Micro Biotec’13, Portuguese Congress of Microbiology and Biotechnology, Aveiro, Portugal, 2013.
  19. Vera Machado; Raquel Costa; Peixoto, Daniela; Rui M. V. Abreu; Ricardo C. Calhelha; Isabel C.F. R. Ferreira; Raquel Soares; Maria-João R.P.Queiroz. "New di(hetero)arylthioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase Inhibitors: docking, synthesis, enzymatic and cellular assays". Trabalho apresentado em International Conference On Medicinal Chemistry, 49th RICT, Nice, França., 2013.
  20. Maria-João R.P. Queiroz; Agathe Begouin; Joana F. Campos; Peixoto, Daniela; Hugo J. C. Froufe; Ricardo C. Calhelha; Rui M. V. Abreu; Isabel C.F.R. Ferreira. "Synthesis of new n-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors of VEGFR2 using rational design". Trabalho apresentado em ” International Conference On Medicinal Chemistry, 49th RICT, Nice, França., 2013.
  21. Agathe Begouin; Peixoto, Daniela; Maria-João R.P. Queiroz. "Synthesis of 3-halo-2-(hetero)arylthienopyridine derivatives as key precursors of potential antitumorals". Trabalho apresentado em International Conference on Medicinal Chemistry, 49th RICT, Nice, França., 2013.
  22. Peixoto, Daniela; H. Viana; A. Goth; C.S. Marques; A.J. Burke. "INMOLFARM – Nova família de fármacos para doenças neurodegenerativas". Trabalho apresentado em Jornadas de Química - Universidade de Évora, 2013.
  23. Ricardo C. Calhelha; Peixoto, Daniela; Pedro Soares; Isabel C.F. R. Ferreira; Rui M.V. Abreu; Maria-João R.P. Queiroz. "Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hétero)arylethers and di(hétero)arylamines in the thieno[3,2-b]pyridine series". Trabalho apresentado em 3º Encontro Nacional de Química Terapêutica, Aveiro, 2012.
  24. Peixoto, Daniela; Ricardo C. Calhelha; Pedro Soares; Rui M.V. Abreu; Hugo J. C. Froufe; Isabel C.F. R. Ferreira; Raquel Costa; Raquel Soares; Maria-João R.P. Queiroz. "1-Aryl-3-[4-(thieno[3,2-b]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking, enzumatic and celular assays". Trabalho apresentado em 3º Encontro Nacional de Química Terapêutica, Aveiro, 2012.
  25. Ricardo C. Calhelha; Peixoto, Daniela; Pedro Soares; Rui M.V. Abreu; Isabel C.F. R. Ferreira; Maria-João R.P. Queiroz. "Thieno [3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, EFMC-ISMC, Berlin, 2012.
  26. Maria-João R.P. Queiroz; Peixoto, Daniela; Pedro Soares; Rui M.V. Abreu; Ricardo C. Calhelha; Isabel C.F. R. Ferreira; Raquel Costa; Raquel Soares. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, EFMC-ISMC, Berlin, 2012.
  27. Peixoto, Daniela; Maria-João R.P. Queiroz; Rui M.V. Abreu; Hugo J. C. Froufe; Ricardo C. Calhelha; Isabel C.F. R. Ferreira. "Synthesis of novel 1-ary-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylyhio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, EFMC-ISMC, Berlin, 2012.
  28. Agathe Begouin; Peixoto, Daniela; Maria-João R.P. Queiroz. "Synthesis of thienopyridine derivatives as potential antitumorals and/or antiangiogenics". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, EFMC-ISMC, Berlin., 2012.
  29. Maria-João R.P. Queiroz; Peixoto, Daniela; Ricardo C. Calhelha. "Synthesis of tetracyclic systems and (thio)ureas from aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series". Trabalho apresentado em 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, FCUL-Lisbon, 2012.
  30. Peixoto, Daniela; Pedro Soares; Maria-João R.P. Queiroz. "Synthesis of di(hetreo)arylamines and ethers in the thieno[3,2-b]pyridine series by metal-catalyzed couplings". Trabalho apresentado em 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, FCUL-Lisbon, 2012.
  31. Agathe Begouin; Peixoto, Daniela; Maria-João R.P. Queiroz. "Synthesis of 3-Halo-2-(hetero)arylthienopyridines through a tree-step methodology from 2,3-dihalopyridines, methanethiolate, (hetero)arylalkynes and electrophiles". Trabalho apresentado em 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, FCUL-Lisbon, 2012.
  32. Maria-João R.P. Queiroz; Peixoto, Daniela; Pedro Soares; Rui M.V. Abreu; Hugo J. C. Froufe; Ricardo C. Calhelha; Isabel C.F. R. Ferreira; Raquel Costa; Raquel Soares. "Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: Synthesis, docking studies, enzymatic and cellular assays". Trabalho apresentado em 48th International Conference on Medicinal Chemistry, Poitiers, France., 2012.
  33. Elisabete M. S. Castanheira; Cátia N. C. Costa; Ana Rita O. Rodrigues; Peixoto, Daniela; Maria-João R.P. Queiroz. "Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives of thieno[3,2-b]pyridines in solution and in nanoliposomes". Trabalho apresentado em MAF12 - 12th International Conference on Methods and Applications of Fluorescence: Spectroscopy, Imaging and Probes, Strasbourg, France, 2011.
  34. Maria-João R.P. Queiroz; Sofia Dias; Pedro Soares; Peixoto, Daniela. "Synthesis of di(hetero)arylethers in the thieno[3,2-b]pyridine seres by copper/N,N-dimethylglycine catalyzed C-O coupling". Trabalho apresentado em 17th European Meeting of Organic Chemistry, Crete, Greece, 2011.
  35. Maria-João R.P. Queiroz; Peixoto, Daniela. "Synthesis of 1,3-diarylureas derivatives of (thieno[3,2-b]pyridine-7-ylthio)anilines". Trabalho apresentado em XXII Encontro Nacional da Sociedade Portuguesa de Química, Braga, Portugal, 2011.
  36. Peixoto, Daniela; Sofia Dias; Hugo Froufe; Rui M.V. Abreu; Isabel C.F. R. Ferreira; Maria-João R.P. Queiroz. "Methyl 3-amino-6-[4- or 3- or 2- (3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry, Porto, Portugal, 2011.
  37. Peixoto, Daniela; Ricardo C. Calhelha; Sofia Dias; Hugo Froufe; Rui M. V. Abreu; Isabel C.F. R. Ferreira; Maria-João R.P. Queiroz. "Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry, Porto, Portugal, 2011.

Propriedade Intelectual

Patente
  1. Peixoto, Daniela; Burke, A.J.. 2016. "One-pot Process for Preparing 1,4-Dibenzodiazepines via Buchwald-Hartwig Chemistry".
  2. Peixoto, Daniela; Viana, H; Goth, A; Marques, C.S.; Burke, A.J.. 2015. "Process for preparing cyclic chiral amines and alcohols by intramolecular catalytic arylation of boronic acid or ester aldehydes and imine substrates".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/01/17 Fun with Cyclizations: Accessing Heterocyclic Bioactive Compounds via New Methodologies 12ºENQO and 5ºENQT
Sociedade Portuguesa de Química (Coimbra, Portugal)
2015/09/02 Synthesis of alkyl 3-aminothieno[3,2-b]pyridine-2-carboxylates derivatives by metal-catalyzed reactions and driven intramolecular cyclizations International Symposium on Synthesis and Catalysis - ISySyCat 2015
ISySyCat 2015 (Évora, Portugal)
2013/09/04 New strategies for the synthesis of 2-(hetero)arylthieno[2,3-b] or [3,2-b]pyridine scaffolds from 2,3-dihalopyridines 10º Encontro Nacional de Química Orgânica - 1º Simpósio Luso-Brasileiro de Química Orgânica
Sociedade Portuguesa de Química (Lisboa, Portugal)
2012/11/28 Synthesis, docking, enzimatic and celular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors 3º Encontro Nacional de Química Terapêutica
Sociedade Portuguesa de Química (Aveiro, Portugal)
2011/07/31 Synthesis of 1,3-diaryl(thio)ureas in the thieno[3,2-b]pyridine series by palladium-catalyzed couplings and reactions with aryliso(thio)cyanates 23rd International Congress on Heterocyclic Chemistry
Heterocyclic chemistry (Glasgow, Reino Unido)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2018/09 - 2019/02 Synthesis of anthracene derivatives containing a 1,3-diazotized spacer
Orientador
Applied Chemistry (Licenciatura/Bacharelato)
Universidade Nova de Lisboa, Portugal
2017/09 - 2018/06 Computational studies and synthesis of tricyclic compounds containing a 1,3-diamine type spacer as potential acetylcholinesterase inhibitors
Coorientador
Biochemistry (Licenciatura/Bacharelato)
Universidade Nova de Lisboa, Portugal
2017/10 - 2018/05 Synthesis oh 1,3-diamine by DNA interection
Orientador
Chemical application (Licenciatura/Bacharelato)
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/11/06 - 2019/11/08 This event was focused overcoming specific weaknesses in tendon biology to advance the design of advanced regenerative therapies. (2019/11/06 - 2019/11/08)
Conferência (Membro da Comissão Organizadora)
Biomaterials Biodegradables and Biomimetics, Portugal
2015/09/02 - 2015/09/04 The conference will focus on key topics in contemporary organic and organometallic synthesis and catalysis, which are of relevance to both academic and industrial chemists alike. We anticipate a good mix of participants from academia and industry. The conference will focus on the following key areas: Total synthesis of natural products. Synthesis in Medicinal chemistry and chemical biology. New reagents, catalysts, strategies and concepts for organic synthesis. Biocatalysis in synthesis. Organocatalysis. (2015/09/02 - 2015/09/04)
Conferência (Membro da Comissão Organizadora)
Universidade de Évora, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2020/02/13 - 2020/02/13 EIT Health Accelerator session to get to know the entrepreneurship opportunities for researchers and star-up companies to bring our healthcare products to the market (https://eu.eventscloud.com/ehome/200200503/200491734/)
Outro
EIT Health Accelerator Info Session
Biomaterials Biodegradables and Biomimetics, Portugal
2020/02/06 - 2020/02/06 Quality Management System training on ISI 9001:2015 - It was provided the main tools and information to comply with the rules and quality management actions of I3Bs. With highligh during the presentation: i) Quality Manual, ii) Quality policy, iii) Strategic intention, iv) Management of Interested Parties, v) QMS indicators/Objectives and vi) the other SOPs. This training was fundamental to ensure the quality on the performed research and management.
Outro
QMS Trainning Action
Biomaterials Biodegradables and Biomimetics, Portugal
2019/07/11 - 2019/07/12 In this fields of “Nanotechnology in cancer detection and treatment” in FoReCaST Workshop
Oficina (workshop)
FoReCaST 2nd Workshop,
Biomaterials Biodegradables and Biomimetics, Portugal
2019/07/08 - 2019/07/10 In the fields of “Molecular and biological mechanisms of tendon homeostasis and repair” in Achilles Conference
Conferência
First Achilles Conference
Biomaterials Biodegradables and Biomimetics, Portugal
2018/11/09 - 2018/11/09 Workshop organized by European Patent Academy (EPO) e ao Instituto Nacional da Propriedade Industrial (INPI)
Oficina (workshop)
From Research to Patent
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2015/02 - 2015/02 I participated in workshops performed by Kerry Gilmore (Max Planck Institute of Colloids and Interfaces, Biomolecular Systems Department,) about Continuous Flow Chemistry.
Oficina (workshop)
Continuous Flow Chemistry
Universidade de Évora, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2018/05/21 Iodo Hipervalente: Um mundo de possibilidades para novas reações de transferência de grupos funcionais
Arguente principal
Catarina Salgueiro (Outro)
Universidade Nova de Lisboa, Portugal
2017/02/13 Síntese de metabolitos de drogas de abuso
Arguente principal
Crisanto Brito (Outro)
Universidade Nova de Lisboa, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016/02 - 2016/07 Assistant teacher practical classes in General Organic Chemistry B Mestrado Integrado em Engenharia de Materiais and Mestrado Integrado em Engenharia de Micro e Nanotecnologias (Mestrado integrado) Universidade Nova de Lisboa, Portugal

Membro de associação

Nome da associação Tipo de participação
2017/01/01 - Atual Sociedade Portuguesa de Química Member

Tutoria

Tópico Nome do aluno
2020/01/04 - 2024/01/03 Bioadhesive materials for regeneration of Spinal Cord Cátia Correia
2017/09/01 - 2018/10 Organic Chemistry laboratory (LAQV-FCT/UNL) Gabriela Rodrigues Malta
2018/01 - 2018/07 Organic Chemistry laboratory (LAQV-FCT/UNL) Rita Jesus
2014/09 - 2015/10 Organic Chemistry laboratory (CQ-UÉ) Cátia Marques Guarda
2012/09 - 2013/02 Organic Chemistry laboratory (CQ-UM) Joana F. Campos
2011/09 - 2012/10 Organic Chemistry laboratory (CQ-UM) Hugo Ricardo Viana
Distinções

Prémio

2013 Best poster - Jornadas de Química - Universidade de Évora
Universidade de Évora Centro de Química de Évora, Portugal