Quan Zhang (C71F-81BE-BD22)

Curriculum Vitae

Quan Zhang

Quan Zhang is an Associate Professor of Endocrine Cell Physiology at the Radcliffe Department of Medicine of the University of Oxford (UK) and an Investigador Auxiliar (Assistant Researcher) at the Centro de Inovação em Biomedicina e Biotecnologia (CIBB) of the Universidade de Coimbra (Portugal). He completed a Doctor of Philosophy degree in the Department of Clinical Sciences at Lund University in 2008 and a Bachelor's degree in Biology in 2002 at Shandong University. To date, he has worked in 4 international laboratories (Sweden, Canada, Portugal and the UK), published 47 articles in international scientific journals (12 with first authorship and 9 with senior authorship; 22 papers in the past 5 years), reaching an h-index of 31 with a total citation of 3139 (source: Web of Science). He supervised 4 postdoctoral research fellows and co-supervised 4 PhD theses. He secured 9 grants as the Principal Investigator and 3 grants as the Co-Investigator (total grants= 3.3 million euros). He has received 2 national awards (one Swedish and one Chinese) and recently was awarded as an Outstanding Editorial Board Member by the Journal of Chronic Diseases and Translational Medicine. He is a member of the editorial boards of 3 international academic journals (Diabetes, Biology and the Journal of Chronic Diseases and Translational Medicine) and is a regular reviewer for international scientific journals (e.g., Cell Systems, Cell Reports and Diabetes) and research funding bodies (e.g., MRC, BBSRC and Stanford Diabetes Research Center). He has been invited to give seminars/lectures at international conferences (e.g., European Association for the Study of Diabetes Annual Meeting, American Diabetes Annual Meeting and European Society for Clinical Investigation Annual Scientific Meeting) or research institutes (e.g., Cornell University and Gothenburg University). He is a regular organizer of the scientific seminars held at the Oxford Centre for Diabetes, Endocrinology and Metabolism and he participated in one BRC-hosted patient meeting. He is a member of the organising committee of the annual CIBB meeting (2023). He works in the area of Medical and Health Sciences with an emphasis on Basic Medicine and Physiology in particular. He also works on Natural sciences with an emphasis on Biological Sciences, specifically on Biophysics and Cell Biology.

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Identificação

Identificação pessoal

Nome completo: Quan Zhang

Nomes de citação

Zhang, Quan

Identificadores de autor

Ciência ID: C71F-81BE-BD22
ORCID iD: 0000-0002-3626-4855

Endereços de correio eletrónico

quan.zhang@ocdem.ox.ac.uk (Profissional)
quanzhang@cnc.uc.pt (Profissional)

Telefones

Telemóvel

(+44) 7427691819 (Pessoal)
(+351) 964293418 (Pessoal)

Moradas

OCDEM, churchill hospital, OX3 7LE, OXFORD, Oxfordshire, Reino Unido (Profissional)
Centro de Neurociências e Biologia Celular (CNC) Universidade de Coimbra, Pólo I - Edifício da FMUC, Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
Ciências Naturais - Ciências Biológicas - Biofísica
Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Chinês (Idioma materno)

Formação

	Grau	Classificação
2003/06/01 - 2008/03/18 Concluído	Department of Clinical Sciences (Doctor of Philosophy) Especialização em Physiology Lunds Universitet, Suécia "Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion" (TESE/DISSERTAÇÃO)
1998/09/01 - 2002/07/01 Concluído	Biology (Bachelor) Especialização em Zoology Shandong University, China

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/01/16 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

2011/10/01 - 2015/09/01	Pós-doutorado (Investigação)	University of Oxford Radcliffe Department of Medicine, Reino Unido
	University of Oxford Radcliffe Department of Medicine, Reino Unido (...)
2011/05/08 - 2011/10/01	Pós-doutorado (Investigação)	University of Alberta, Canadá
	University of Alberta, Canadá
2008/03/18 - 2011/05/16	Pós-doutorado (Investigação)	Nuffield Department of Clinical Medicine, Reino Unido
	Nuffield Department of Clinical Medicine, Reino Unido (...)

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2023/01/01 - Atual	Associate Professor of Endocrine Cell Physiology	University of Oxford, Reino Unido

2015/09/01 - 2023/01/01	University Research Lecturer	University of Oxford Radcliffe Department of Medicine, Reino Unido
	University of Oxford Radcliffe Department of Medicine, Reino Unido (...)

Projetos

Bolsa

	Designação	Financiadores
2021/03/01 - 2025/02/28	The role of impaired glucagon secretion in life-threatening hypoglycaemia of type 1 diabetes: mechanism and therapeutic potential MR/V011979/1 Co-Investigator University of Oxford Radcliffe Department of Medicine, Reino Unido	UK Research and Innovation Medical Research Council Swindon Em curso
2022 - 2025	Alpha-cell function in T1D patients with and without severe hypoglycaemia Hemsley Co-Investigador Responsável (Co-IR)
2023 - 2024	Decipher the mechanisms underlying islet hormone secretory defects in recurrent hypoglycaemia BRC Investigador responsável
2022 - 2024	Metabolic memory of islet delta cells in defective glucagon secretion in recurrent hypoglycaemia EFSD Investigador responsável
2018/03/31 - 2022/03/30	Investigation of intra-islet glucagon- somatostatin- glucagon feedback mechanisms IEC\NSFC\170394 Investigador responsável Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido	The Royal Society Em curso
2015/09 - 2022/02	KATP channel-dependent and –independent regulation of the glucagon-secreting pancreatic a-cell grant.DUK-14/0005128 Investigador responsável	Diabetes UK
2018/04/01 - 2021/03/31	Investigation of the role of ER Ca2+ in the glucose regulation of glucagon secretion n/a Investigador responsável Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido	European Foundation for the Study of Diabetes Em curso
2019/12/01 - 2021/03/30	Paracrine feedback loops in pancreatic islets and their impact in hypoglycaemia WISSF Investigador responsável Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido	University of Oxford Medical Sciences Division Em curso
2019/02/01 - 2020/05/01	The role of tetraspanin-7 in insulin secretion from pancreatic ß-cells MSIF Investigador responsável Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido	University of Oxford Medical Sciences Division Em curso
2017/09/01 - 2018/04/01	Developing Fluorescent Bioprobes for Studying Human Pancreatic Alpha Cell Physiology n/a Investigador responsável Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido	University of Oxford Radcliffe Department of Medicine Concluído
2016/04 - 2017/10	Membrane potential independent regulation of glucagon secretion from the pancreatic alpha-cells 152/052 Investigador responsável	University of Oxford John Fell Fund Concluído

Produções

Publicações

Artigo em revista

Hill, Thomas G.; Gao, Rui; Benrick, Anna; Kothegala, Lakshmi; Rorsman, Nils; Santos, Cristiano; Acreman, Samuel; et al. "Loss of electrical ß-cell to d-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes". Nature Metabolism (2024): http://dx.doi.org/10.1038/s42255-024-01139-z.
10.1038/s42255-024-01139-z
Samuel Acreman; Jinfang Ma; Geoffrey Denwood; Rui Gao; Andrei Tarasov; Patrik Rorsman; Quan Zhang. "The endoplasmic reticulum plays a key role in a-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets". iScience (2024): https://doi.org/10.1016/j.isci.2024.109665.
10.1016/j.isci.2024.109665
Gandasi, Nikhil R.; Gao, Rui; Kothegala, Lakshmi; Pearce, Abigail; Santos, Cristiano; Acreman, Samuel; Basco, Davide; et al. "GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion". Diabetologia 67 3 (2023): 528-546. http://dx.doi.org/10.1007/s00125-023-06060-w.
10.1007/s00125-023-06060-w
Zhang, Quan; Huising, Mark O.; Da Silva Xavier, Gabriela; Hauge-Evans, Astrid C.. "Editorial: The pancreatic islet – a multifaceted hub of inter-cellular communication". Frontiers in Endocrinology 14 (2023): http://dx.doi.org/10.3389/fendo.2023.1182897.
10.3389/fendo.2023.1182897
Rui Gao; Samuel Acreman; Jinfang Ma; Fernando Abdulkader; Anna Wendt; Quan Zhang. "a-cell electrophysiology and the regulation of glucagon secretion". Journal of Endocrinology (2023): https://doi.org/10.1530/JOE-22-0295.
10.1530/JOE-22-0295
McLaughlin, Kerry; Acreman, Samuel; Nawaz, Sameena; Cutteridge, Joseph; Clark, Anne; Knudsen, Jakob G.; Denwood, Geoffrey; et al. "Loss of tetraspanin-7 expression reduces pancreatic ß-cell exocytosis Ca²⁺ sensitivity but has limited effect on systemic metabolism". Diabetic Medicine 39 12 (2022): http://dx.doi.org/10.1111/dme.14984.
10.1111/dme.14984
Yingying Ye; Mohammad Barghouth; Haiqiang Dou; Cheng Luan; Yongzhi Wang; Alexandros Karagiannopoulos; Xiaoping Jiang; et al. "A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic ß-cells". Nature Communications (2022): https://doi.org/10.1038/s41467-022-31103-y.
10.1038/s41467-022-31103-y
Anna Veprik; Geoffrey Denwood; Dong Liu; Rula Bany Bakar; Valentin Morfin; Kara McHugh; Nchimunya N. Tebeka; et al. Autor correspondente: James Cantley. "Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.". Communications Biology (2022):
No prelo
Samuel Acreman; Quan Zhang. "Regulation of a-cell glucagon secretion: The role of second messengers". Chronic Diseases and Translational Medicine (2021): https://doi.org/10.1016/j.cdtm.2021.06.001.
10.1016/j.cdtm.2021.06.001
Gao R; Fu Q; Jiang HM; Shen M; Zhao RL; Qian Y; He YQ; et al. Autor correspondente: Yang T. "Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes". iScience 24 4 (2021): 102265-102265. http://dx.doi.org/10.1016/j.isci.2021.102265.
10.1016/j.isci.2021.102265
Rui Gao; Tao Yang; Quan Zhang. "d-Cells: The Neighborhood Watch in the Islet Community". Biology 10 2 (2021): 74-74. https://doi.org/10.3390/biology10020074.
10.3390/biology10020074
Oduori, Okechi S.; Murao, Naoya; Shimomura, Kenju; Takahashi, Harumi; Zhang, Quan; Dou, Haiqiang; Sakai, Shihomi; et al. "Gs/Gq signaling switch in ß cells defines incretin effectiveness in diabetes". Journal of Clinical Investigation 130 12 (2020): 6639-6655. http://dx.doi.org/10.1172/jci140046.
10.1172/jci140046
Quan Zhang; Haiqiang Dou; Patrik Rorsman. "‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon-secreting a-cells". The Journal of Physiology 598 21 (2020): 4765-4780. https://doi.org/10.1113/JP279775.
10.1113/JP279775
Satin, Leslie S.; Zhang, Quan; Rorsman, Patrik. "“Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets". Diabetes 69 5 (2020): 830-836. http://dx.doi.org/10.2337/dbi19-0012.
10.2337/dbi19-0012
Quan Zhang; Elisa Vergari; Geoffrey Denwood; Albert Salehi; Julie Adam; Ahmed Alrifaiy; Ingrid Wernstedt Asterholm; et al. "Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells". Nature Metabolism (2020): https://doi.org/10.1038/s42255-019-0158-0.
10.1038/s42255-019-0158-0
Quan Zhang; Elisa Vergari; Jakob G. Knudsen; Reshma Ramracheya; Albert Salehi; Julie Adam; Ingrid Wernstedt Asterholm; et al. "Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-018-08193-8.
10.1038/s41467-018-08193-8
Denwood, Geoffrey; Tarasov, Andrei; Salehi, Albert; Vergari, Elisa; Ramracheya, Reshma; Takahashi, Harumi; Nikolaev, Viacheslav O.; et al. "Glucose stimulates somatostatin secretion in pancreatic d-cells by cAMP-dependent intracellular Ca2+ release". The Journal of General Physiology 151 9 (2019): 1094-1115. http://dx.doi.org/10.1085/jgp.201912351.
10.1085/jgp.201912351
Knudsen, Jakob G.; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I.; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V.; et al. "Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production". Cell Metabolism 29 2 (2019): 430-442.e4. http://dx.doi.org/10.1016/j.cmet.2018.10.003.
10.1016/j.cmet.2018.10.003
Quan Zhang; Davide Basco; Albert Salehi; Andrei Tarasov; Wanda Dolci; Pedro Herrera; Ioannis Spiliotis; et al. "a-cell glucokinase suppresses glucose-regulated glucagon secretion". Nature Communications 9 1 (2018): https://doi.org/10.1038/s41467-018-03034-0.
10.1038/s41467-018-03034-0
Ramracheya, Reshma; Chapman, Caroline; Chibalina, Margarita; Dou, Haiqiang; Miranda, Caroline; González, Alejandro; Moritoh, Yusuke; et al. "GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels". Physiological Reports 6 17 (2018): e13852. http://dx.doi.org/10.14814/phy2.13852.
10.14814/phy2.13852
Mahdieh Godazgar; Quan Zhang; Margarita V. Chibalina; Patrik Rorsman. "Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells". The Journal of Physiology 596 9 (2018): 1601-1626. https://doi.org/10.1113/JP275587.
10.1113/JP275587
Hamilton, Alexander; Zhang, Quan; Salehi, Albert; Willems, Mara; Knudsen, Jakob G.; Ringgaard, Anna K.; Chapman, Caroline E.; et al. "Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+Mobilization From Acidic Stores in Pancreatic a-Cells". Diabetes 67 6 (2018): 1128-1139. http://dx.doi.org/10.2337/db17-1102.
10.2337/db17-1102
Quinault, Aurore; Leloup, Corinne; Denwood, Geoffrey; Spiegelhalter, Coralie; Rodriguez, Marianne; Lefebvre, Philippe; Messaddeq, Nadia; et al. "Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle". PLOS ONE 13 3 (2018): e0193882. http://dx.doi.org/10.1371/journal.pone.0193882.
10.1371/journal.pone.0193882
Adam, Julie; Ramracheya, Reshma; Chibalina, Margarita V.; Ternette, Nicola; Hamilton, Alexander; Tarasov, Andrei I.; Zhang, Quan; et al. "Fumarate Hydratase Deletion in Pancreatic ß Cells Leads to Progressive Diabetes". Cell Reports 20 13 (2017): 3135-3148. http://dx.doi.org/10.1016/j.celrep.2017.08.093.
10.1016/j.celrep.2017.08.093
Zhang, Quan; Babinsky, Valerie N; Hannan, Fadil M; Ramracheya, Reshma D; Nesbit, M Andrew; Hugill, Alison; Bentley, Liz; et al. "Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy". Endocrinology 158 8 (2017): 2486-2502. http://dx.doi.org/10.1210/en.2017-00111.
10.1210/en.2017-00111
Briant, Linford J. B.; Zhang, Quan; Vergari, Elisa; Kellard, Joely A.; Rodriguez, Blanca; Ashcroft, Frances M.; Rorsman, Patrik. "Functional identification of islet cell types by electrophysiological fingerprinting". Journal of The Royal Society Interface 14 128 (2017): 20160999. http://dx.doi.org/10.1098/rsif.2016.0999.
10.1098/rsif.2016.0999
Briant, Linford; Salehi, Albert; Vergari, Elisa; Zhang, Quan; Rorsman, Patrik. "Glucagon secretion from pancreatic a-cells". Upsala Journal of Medical Sciences 121 2 (2016): 113-119. http://dx.doi.org/10.3109/03009734.2016.1156789.
10.3109/03009734.2016.1156789
Brereton, Melissa F.; Vergari, Elisa; Zhang, Quan; Clark, Anne. "Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?". Journal of Histochemistry & Cytochemistry 63 8 (2015): 575-591. http://dx.doi.org/10.1369/0022155415583535.
10.1369/0022155415583535
Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C.; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; et al. "Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic ß Cells". Journal of Biological Chemistry 290 35 (2015): 21376-21392. http://dx.doi.org/10.1074/jbc.m115.671248.
10.1074/jbc.m115.671248
Zhang, Quan; Chibalina, Margarita V.; Bengtsson, Martin; Groschner, Lukas N.; Ramracheya, Reshma; Rorsman, Nils J. G.; Leiss, Veronika; et al. "Na+current properties in islet a- and ß-cells reflect cell-specific Scn3a and Scn9a expression". The Journal of Physiology 592 21 (2014): 4677-4696. http://dx.doi.org/10.1113/jphysiol.2014.274209.
10.1113/jphysiol.2014.274209
Brereton, Melissa F.; Iberl, Michaela; Shimomura, Kenju; Zhang, Quan; Adriaenssens, Alice E.; Proks, Peter; Spiliotis, Ioannis I.; et al. "Reversible changes in pancreatic islet structure and function produced by elevated blood glucose". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms5639.
10.1038/ncomms5639
Rorsman, Patrik; Ramracheya, Reshma; Rorsman, Nils J. G.; Zhang, Quan. "ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion". Diabetologia 57 9 (2014): 1749-1761. http://dx.doi.org/10.1007/s00125-014-3279-8.
10.1007/s00125-014-3279-8
Latreille, Mathieu; Hausser, Jean; Stützer, Ina; Zhang, Quan; Hastoy, Benoit; Gargani, Sofia; Kerr-Conte, Julie; et al. "MicroRNA-7a regulates pancreatic ß cell function". Journal of Clinical Investigation 124 6 (2014): 2722-2735. http://dx.doi.org/10.1172/jci73066.
10.1172/jci73066
Zhang, Quan; Ramracheya, Reshma; Lahmann, Carolina; Tarasov, Andrei; Bengtsson, Martin; Braha, Orit; Braun, Matthias; et al. "Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes". Cell Metabolism 18 6 (2013): 871-882. http://dx.doi.org/10.1016/j.cmet.2013.10.014.
10.1016/j.cmet.2013.10.014
Rorsman, Patrik; Braun, Matthias; Zhang, Quan. "Regulation of calcium in pancreatic a- and ß-cells in health and disease". Cell Calcium 51 3-4 (2012): 300-308. http://dx.doi.org/10.1016/j.ceca.2011.11.006.
10.1016/j.ceca.2011.11.006
Hoppa, M. B.; Jones, E.; Karanauskaite, J.; Ramracheya, R.; Braun, M.; Collins, S. C.; Zhang, Q.; et al. "Multivesicular exocytosis in rat pancreatic beta cells". Diabetologia 55 4 (2011): 1001-1012. http://dx.doi.org/10.1007/s00125-011-2400-5.
10.1007/s00125-011-2400-5
Rorsman, Patrik; Eliasson, Lena; Kanno, Takahiro; Zhang, Quan; Gopel, Sven. "Electrophysiology of pancreatic ß-cells in intact mouse islets of Langerhans". Progress in Biophysics and Molecular Biology 107 2 (2011): 224-235. http://dx.doi.org/10.1016/j.pbiomolbio.2011.06.009.
10.1016/j.pbiomolbio.2011.06.009
Walker, J. N.; Ramracheya, R.; Zhang, Q.; Johnson, P. R. V.; Braun, M.; Rorsman, P.. "Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?". Diabetes, Obesity and Metabolism 13 (2011): 95-105. http://dx.doi.org/10.1111/j.1463-1326.2011.01450.x.
10.1111/j.1463-1326.2011.01450.x
Ramracheya, R.; Ward, C.; Shigeto, M.; Walker, J. N.; Amisten, S.; Zhang, Q.; Johnson, P. R.; Rorsman, P.; Braun, M.. "Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in alpha-Cells Inhibits Glucagon Secretion From Human Islets". Diabetes 59 9 (2010): 2198-2208. http://dx.doi.org/10.2337/db09-1505.
10.2337/db09-1505
Zhang, Quan; De Marinis, Yang Z.; Salehi, Albert; Ward, Caroline E.; Abdulkader, Fernando; Bengtsson, Martin; Braha, Orit; et al. "GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis". Cell Metabolism 11 6 (2010): 543-553. http://dx.doi.org/10.1016/j.cmet.2010.04.007.
10.1016/j.cmet.2010.04.007
Collins, S. C.; Hoppa, M. B.; Walker, J. N.; Amisten, S.; Abdulkader, F.; Bengtsson, M.; Fearnside, J.; et al. "Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles". Diabetes 59 5 (2010): 1192-1201. http://dx.doi.org/10.2337/db09-0791.
10.2337/db09-0791
Hoppa, Michael B.; Collins, Stephan; Ramracheya, Reshma; Hodson, Leanne; Amisten, Stefan; Zhang, Quan; Johnson, Paul; et al. "Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules". Cell Metabolism 10 6 (2009): 455-465. http://dx.doi.org/10.1016/j.cmet.2009.09.011.
10.1016/j.cmet.2009.09.011
Braun, M.; Ramracheya, R.; Amisten, S.; Bengtsson, M.; Moritoh, Y.; Zhang, Q.; Johnson, P. R.; Rorsman, P.. "Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells". Diabetologia 52 8 (2009): 1566-1578. http://dx.doi.org/10.1007/s00125-009-1382-z.
10.1007/s00125-009-1382-z
Gustavsson, Natalia; Wei, Shun-Hui; Hoang, Dong Nhut; Lao, Ye; Zhang, Quan; Radda, George K.; Rorsman, Patrik; Südhof, Thomas C.; Han, Weiping. "Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas". The Journal of Physiology 587 6 (2009): 1169-1178. http://dx.doi.org/10.1113/jphysiol.2008.168005.
10.1113/jphysiol.2008.168005
Zhang, Quan; Galvanovskis, Juris; Abdulkader, Fernando; Partridge, Christopher J; Göpel, Sven O; Eliasson, Lena; Rorsman, Patrik. "Cell coupling in mouse pancreatic ß-cells measured in intact islets of Langerhans". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 366 1880 (2008): 3503-3523. http://dx.doi.org/10.1098/rsta.2008.0110.
10.1098/rsta.2008.0110
Braun, M.; Ramracheya, R.; Bengtsson, M.; Zhang, Q.; Karanauskaite, J.; Partridge, C.; Johnson, P. R.; Rorsman, P.. "Voltage-Gated Ion Channels in Human Pancreatic -Cells: Electrophysiological Characterization and Role in Insulin Secretion". Diabetes 57 6 (2008): 1618-1628. http://dx.doi.org/10.2337/db07-0991.
10.2337/db07-0991
Zhang, Quan; Bengtsson, Martin; Partridge, Chris; Salehi, Albert; Braun, Matthias; Cox, Roger; Eliasson, Lena; et al. "R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion". Nature Cell Biology 9 4 (2007): 453-460. http://dx.doi.org/10.1038/ncb1563.
10.1038/ncb1563
Göpel, Sven; Zhang, Quan; Eliasson, Lena; Ma, Xiao-Song; Galvanovskis, Juris; Kanno, Takahiro; Salehi, Albert; Rorsman, Patrik. "Capacitance measurements of exocytosis in mouse pancreatic a-, ß- and d-cells within intact islets of Langerhans". The Journal of Physiology 556 3 (2004): 711-726. http://dx.doi.org/10.1113/jphysiol.2003.059675.
10.1113/jphysiol.2003.059675

Outros

Outra produção

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes. 2020. Gao, R.; Fu, Q.; Jiang, H.-M.; Shen, M.; Zhao, R.-L.; Qian, Y.; He, Y.-Q.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102909397&partnerID=MN8TOARS.
10.1101/2020.08.21.195453

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2022/09	Role of delta cells in islet regulation	58th European Association for the Study of Diabetes Annual Meeting European Association for the Study of Diabetes (Stockholm, Suécia)
2021/06	Alpha-delta cell interaction in pancreatic islets and its metabolic memory	55th European Society for Clinical Investigation Annual Scientific Meeting European Society for Clinical Investigation
2020/09	delta cell regulatory mechanism - feedback system from the pancreatic beta cells	Islet and Metabolism Forum Nanjing Medical University (China)
2020/06/13	the Elusive Delta Cell—Mechanisms Underlying Somatostatin Release	American Diabetes Association Annual Meeting American Diabetes Association (chicago, Estados Unidos)
2019/09/23	cAMP dependent regulation of somatostatin secretion from pancreatic delta cells	2019 Islet and Metabolism Forum Nanjing Medical University (Nanjing , China)
2019/02/20	Intracellular Ca2+ dynamics in non-beta cells	Metabolism symposium Shandong University (Jinan, China)
2018/08/15	Regulation of somatostatin secretion – cAMP dependent pathways	Shandong University Medical School seminar series Shandong University (Jinan, China)
2017/08/18	Electrical activity and Ca2+ oscillations of non-beta cells in pancreatic islet	Gothenburg University Department of Physiology - department talk Department of Physiology, Gothenburg University (Gothenburg, Suécia)
2017/03/16	ion channels in pancreatic islet alpha cells and regulation of glucagon secretion	The Annual Meeting of Japanese Pharmacological Society 2017 Japanese Pharmacological Society (Nagasaki , Japão)
2016/08/18	Glucagon, the alpha-cell and intra-islet paracrine relationships	21st EASD-HAGEDORN OXFORD workshop European Association for the Study of Diabetes (Oxford, Reino Unido)
2016/02/09	Electrophysiology and Ca2+ dynamics of non-beta cells in pancreatic islets	OCDEM Islet Research Day 2016 - Annual Matthias Braun Lecture Oxford Centre for Diabetes Endocrinology and Metabolism (Oxford, Reino Unido)
2015/12/02	Glucose regulation of glucagon secretion from pancreatic alpha cells	Diabetes UK lecture Diabetes UK (London, Reino Unido)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2020/02/01 - 2024/02/01	alpha cell pathophysiology Coorientador	Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Suécia
2022/01/01 - 2024/01/01	Investigation of the role of intracellular Ca2+ store (endoplasmic reticulum) in alpha cell glucose sensing and glucagon secretion Coorientador	Sichuan University West China Hospital, China University of Oxford Radcliffe Department of Medicine, Reino Unido
2019/07/01 - 2021/05/30	Glucagon-somatostatin-glucagon interaction within the pancreatic islets Coorientador	Physiology (Doutoramento) Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido Nanjing Medical University, China
2014/09/01 - 2018/05/22	Properties of voltage-gated Na+ channels in pancreatic beta-cells Coorientador	Physiology (Doutoramento) University of Oxford Radcliffe Department of Medicine, Reino Unido

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2016 - Atual	Oxford Centre for Diabetes, Endocrinology and Metabolism Weekly Scientific Seminars (2016) Seminário (Coorganizador)	Oxford Centre for Diabetes Endocrinology and Metabolism, Reino Unido
2023 - 2023	CIBB annual meeting (2023 - 2023) Simpósio (Membro da Comissão Organizadora)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2019/06 - 2019/06	BRC Diabetes&Metabolism - PPI MEETING #6 Interaction with patients group Encontro	BRC Diabetes&Metabolism - PPI MEETING #6 NIHR Oxford Biomedical Research Centre, Reino Unido

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2024 - Atual	Diabetes
2020/05 - Atual	Chronic Diseases and Translational Medicine (2095-882X)	KeAi Publishing Communications
2020 - Atual	Biology (2079-7737)	MDPI

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2023 - 2023	Reviewer for grant application	Stanford Diabetes Research Center, Estados Unidos
2021/06 - 2021/09	Evaluation for Medical Research Council (UKRI MRC) Clinical Research Training Fellowship (CRTF) Pre Doc April 2021 Avaliador	Medical Research Council Swindon, Reino Unido UK Research and Innovation, Reino Unido
2020/12 - 2021/03	Evaluation for Medical Research Council (UKRI MRC) Clinical Research Training Fellowship (CRTF) Pre Doc Jan 2021 Avaliador	Medical Research Council Swindon, Reino Unido UK Research and Innovation, Reino Unido
2021/02 - 2021/02	Evaluation for postgraduate student admission for the University of Oxford Avaliador	University of Oxford Radcliffe Department of Medicine, Reino Unido
2020/04 - 2020/04	Reviewer for research project grants (responsive mode) Avaliador		Biotechnology and Biological Sciences Research Council

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2019/10 - 2019/10	Examiner for Confirmation of D.Phil Status (Ms. Clair Duff )	University of Oxford Radcliffe Department of Medicine, Reino Unido
2018/09 - 2018/09	Examiner for Confirmation of D.Phil Status: Ms Katia Mattis	University of Oxford Radcliffe Department of Medicine, Reino Unido
2018/01 - 2018/01	Examiner for Transfer of D.Phil Status: Ms. Clair Duff	University of Oxford Radcliffe Department of Medicine, Reino Unido
2017/09 - 2017/09	Examiner for Confirmation of D.Phil Status: Dr. Hakan Cetin	University of Oxford Nuffield Department of Clinical Neurosciences, Reino Unido

Tutoria

	Tópico	Nome do aluno
2020/05/03 - 2020/08/30	the role of Hexokinase I in glucagon secretion	Sasha Webber
2019/03/01 - 2019/03/11	Insulin resistance and how might it cause diseases	Lee Quill
2014/09/01 - 2015/03/01	An intracellular factor that locks the inactivation of Nav 1.7 channel – Nav channels in pancreatic islet cells	Lukas Groschner

Distinções

Prémio

2021	Outstanding Editorial Board Member Chronic Diseases and Translational Medicine, China
2009	Best Pre-clinical Dissertation in Diabetology of 2008 in Sweden Svensk Förening för Diabetologi, Suécia
2007	Chinese Government Award for Outstanding Self-financed Student Abroad Ministry of Education, China