Sónia Patrícia Dias Duarte (CD1E-CEC0-AFFC)

Curriculum Vitae

Sónia Patrícia Dias Duarte

Identificação

Identificação pessoal

Nome completo: Sónia Patrícia Dias Duarte

Nomes de citação

Duarte, S.P.
Duarte S.
Sónia P. Duarte

Identificadores de autor

Ciência ID: CD1E-CEC0-AFFC

Endereços de correio eletrónico

sonia.duarte@cnc.uc.pt (Profissional)

Telefones

Telefone

239820190 (Profissional)

Moradas

Centro de Inovação em Biomedicina e Biotecnologia (CIBB)/Centro de Neurociências e Biologia Celular (CNC). Universidade de Coimbra, Rua Larga, Faculdade de Medicina Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

https://cibb.uc.pt/research/innovative-therapies/vectors-gene-cell-therapy/ (Profissional)
https://www.cnc.uc.pt/pt/people/s-duarte (Profissional)
https://www.researchgate.net/profile/Sonia-Duarte-3 (Académico)
https://www.linkedin.com/in/sonia-duarte-0760b219/ (Rede social)

Formação

	Grau	Classificação
2023/03/08 - 2023/03/08 Concluído	Webinar on Enabling and advancing mRNA-LNP medicines from concept to clinic (VACCINE INSIGHTS) (Outros) Bioinsights Publishing, Reino Unido
2023/03/01 - 2023/03/01 Concluído	Webinar on Optimize your mRNA process from pDNA template to LNP encapsulation (CELL & GENE THERAPY INSIGHTS) (Outros) Bioinsights Publishing, Reino Unido
2020/06/18 - 2020/06/18 Concluído	X-omics workshop: data standards and multi-omics data integration (Outros) X-omics Organization, Países Baixos
2020/06/10 - 2020/06/10 Concluído	Workshop: "QIAGEN miRNA solutions" (Outros) QIAGEN LLC, Estados Unidos
2019/06/12 - 2019/06/12 Concluído	Workshop: "Everything you need to know about miRNA qPCR" (Outros) QIAGEN LLC, Estados Unidos
2013/02/01 - 2018/07/04 Concluído	Investigating the role of the Let-7 microRNA in Machado-Joseph disease (Pós-doutoramento) Especialização em Neurosciences Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	N/A
2015/07/16 - 2015/07/16 Concluído	Workshop: Bioestatística para trabalhos de investigação (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/05 - 2015/02/06 Concluído	Neuroepigenetics Advanced course of BEB PhD programme (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014 - 2014 Concluído	Course in laboratory animal science- category B + Certificate of Researcher-coordinator for the practice of animal experimentation (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal Direcção-Geral de Alimentação e Veterinária, Portugal
2013/01/15 - 2013/01/17 Concluído	Workshops at the Biogenesis and turnover of small RNAs meeting from Biochemical Society, Advancing Molecular Bioscience (Outros) Biochemical Society, Reino Unido Royal Society of Edinburgh, Reino Unido
2008/03/01 - 2012/07/24 Concluído	PhD in Biochemistry (Doutoramento) Especialização em Biochemical Technology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "On the development of antitumoural therapeutic strategies: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination" (TESE/DISSERTAÇÃO)	PhD with distinction and honors approved by unanim
2009/10 - 2010/07 Concluído	Advanced Communication Skills in English I and II (Outros) Universidade de Coimbra Faculdade de Letras, Portugal
2010/04 - 2010/06 Concluído	Curso de Formação Inicial de Formadores to acquire the CAP certificate (106 h) (Outros) Tecla Center, Portugal
2010/03/04 - 2010/03/05 Concluído	Workshop: "RNA Therapeutics" (Outros) Harvard Medical School, Estados Unidos Fundação Calouste Gulbenkian, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009/09/03 - 2009/09/04 Concluído	GTRV- Summer School « Targeted Drug Delivery » (Outros) École Polytechnique Fédérale de Lausanne, Suiça
2005/02/22 - 2005/02/25 Concluído	Advanced Course on Gene Therapy (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2000/09 - 2004/07/23 Concluído	Biochemistry (Licenciatura) Especialização em Biochemistry Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato" (TESE/DISSERTAÇÃO)	Final grade of 16 (out of 20).

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/09/01 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra, Portugal
	Center for Neurosciences and Cell Biology, Portugal (...)
2019/02/01 - 2023/08/31	Investigador Contratado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/07/05 - 2019/01/31	Investigador Contratado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/02/01 - 2018/07/04	Pós-doutorado (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2012/06/01 - 2012/12/31	Pós-doutorado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2008/03/01 - 2012/07/24	Investigador (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2011/05/01 - 2011/08/05	Investigador visitante (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Centre National de la Recherche Scientifique (UMR 6235 CNRS), França
2010/09/06 - 2010/12/20	Investigador visitante (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Centre National de la Recherche Scientifique (UMR 6235 CNRS), França
2007/06/01 - 2008/02/29	Investigador (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2005/01/01 - 2007/05/31	Investigador (Investigação)	Universidade do Minho, Portugal
	Universidade do Minho, Portugal
2003/09/01 - 2004/07/31	Estagiário de Investigação (Investigação)	Laboratorios Basi S.A.-Industria Farmaceutica, Portugal
	Laboratorios Basi S.A.-Industria Farmaceutica, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2023/04/05 - 2023/09/01	CAREER BREAK: Maternity Leave: Coimbra, Portugal	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014/07/01 - 2015/01/01	CAREER BREAK: Pregnancy/Maternity Leave: Coimbra, Portugal	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neurosciences and Cell Biology, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023/03/01 - Atual	Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism 2022.04788.PTDC Investigador	Fundação para a Ciência e a Tecnologia Em curso
2023/01/01 - Atual	Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3 2022.06127.PTDC Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/09/01 - 2024/02/28	MicroRNA-specific small molecule modifiers as a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3) NAF Young Investigator Award Investigador responsável Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	National Ataxia Foundation Em curso
2021/09/16 - 2024	"Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)" Trampoline Grant 23755 Investigador responsável Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	AFM-Téléthon Em curso
2018/07/06 - 2022/04/05	Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy POCI-01-0145-FEDER-032309 Investigador responsável Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Comissão de Coordenação e Desenvolvimento Regional do Centro Em curso
2020 - 2022/02/28	Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy 686213 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	National Ataxia Foundation
2019 - 2021/12	Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (International Consortium) E-Rare-3 JTC 2017 (International Consortium) Investigador CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06 - 2021/06	The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease POCI-01-0145-FEDER-030737 Investigador Center for Neurosciences and Cell Biology, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Fundação para a Ciência e a Tecnologia Em curso
2017/01 - 2020/12	BRAIN HEALTH 2020-Detecção Precoce,Neuro-modulação e TerapiasAvançadas para Neuropatologias CENTRO-01-0145-FEDER-000008 Investigador Center for Neurosciences and Cell Biology, Portugal	Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE) Foundation for Science and Technology (Lisbon, Portugal) Em curso
2016/04 - 2020/05	ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7) JPCOFUND/0005/2015 (International Consortium) Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	EU Joint Programme Neurodegenerative Disease Research
2016 - 2020/05	JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative JPCOFUND/0001/2015-ESMI (International Consortium) Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	EU Joint Programme Neurodegenerative Disease Research Em curso
2017/03/27 - 2020/03/26	LifeSciences ByCENTRO CENTRO-01-0246-FEDER-000011 Investigador CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)
2016/04 - 2019/03	Gene repair and repression strategies to alleviate Machado-Joseph disease PTDC/NEU-NMC/0084/2014 Investigador Center for Neurosciences and Cell Biology, Portugal	Foundation for Science and Technology (Lisbon, Portugal) Concluído
2015/03 - 2018/12	Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases JPND SynSpread: CD/0001/2013 (International consortium) Investigador Center for Neurosciences and Cell Biology, Portugal	EU Joint Programme Neurodegenerative Disease Research Foundation for Science and Technology (Lisbon, Portugal) Concluído
2013/02/01 - 2018/07/04	Investigating the role of the Let-7 microRNA in Machado-Joseph disease SFRH/BPD/87552/2012 Bolseiro de Pós-Doutoramento Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2016/02	Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration E-Rare4/0003/2012 (International consortium) Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2015/08	Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease PTDC/BIM-MEC/0651/2012 Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2015/06	Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery PTDC/DTP-FTO/0265/2012 Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012/06 - 2012/12	Non-invasive Non-viral Silencing of Machado-Joseph disease PTDC/SAU-FAR/116535/2010 Bolseiro de Investigação Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/03/01 - 2012/03/01	ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination SFRH/BD/32797/2007 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/06 - 2008/02	Development of a novel approach for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids PTDC/BIO/65627/2006 Bolseiro de Investigação Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/01 - 2007/05	Preparação de agentes para Terapia Molecular por purificação e condensação simultânea de plasmídeos em sistemas de duas fases aquosas POCTI BIO/47245/2002 Bolseiro de Investigação Universidade do Minho, Portugal	Universidade do Minho Concluído

Projeto

	Designação	Financiadores
2023/09/01 - Atual	CinTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs 12345 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/07 - Atual	"miRSilencing" project international collaborative project between the Center for Neuroscience and Cell Biology (CNC, UC, Portugal) and PTC Therapeutics (USA) Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal	PTC Therapeutics Inc Em curso
2018/05 - Atual	"Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs International collaborative project between CNC and Wave Life Sciences USA, Inc Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Wave Life Sciences USA, Inc Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/01/01 - 2023/12/31	Center for Innovative Biomedicine and Biotechnology UIDB/04539/2020 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2019/02 - 2019/10	Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA International Collaborative Project between CNC and uniQure Company Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	uniQure NV Concluído
2015/01 - 2017/12	“CNC. IBILI” UID/NEU/04539/2013 Investigador Center for Neurosciences and Cell Biology, Portugal	Foundation for Science and Technology (Lisbon, Portugal) Concluído

Outro

	Designação	Financiadores
2022 - Atual	greenLabsCIBB (gLCIBB) gLCIBB Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso
2018/05/01 - Atual	Collaboration with Wave Life Sciences company, uniQure and Brainvectis in the development of a gene therapy product applied to neurodegenerative disorders, particularly to polyglutamine disorders. INTERNATIONAL NETWORKS Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso
2018 - Atual	Lab management (organizing/ordering/managing the lab products, space/people in the lab) LAB MANAGMENT Outra Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso
2013 - Atual	Collaboration with La Spada AR, who first discovered polyglutamine disorders at the University of Duke INTERNATIONAL NETWORK Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso

Produções

Publicações

Artigo em jornal	Ana Catarina Vinhas; Ana Cristina Ferreira; Carina Henriques; Carolina Silva; et al.. "DOENÇAS RARAS: Uma viagem rara - Cartoon created on purpose for the Journal "THE PUBLIC" to explain a rare disease that affects many Portuguese, Machado-Joseph disease.", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Artigo em revista	Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira. "Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-53542-x. 10.1038/s41598-024-53542-x D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel; L Pereira de Almeida, S P Duarte. "MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Human Gene Therapy 33 23-24 (2022): A1-A212. http://dx.doi.org/10.1089/hum.2022.29225.abstracts. Publicado • 10.1089/hum.2022.29225.abstracts Rui Jorge Nobre; Diana D. Lobo; Carina Henriques; Sonia P. Duarte; Sara M. Lopes; Ana C. Silva; Miguel M. Lopes; et al. "MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics (2021): https://doi.org/10.1089/nat.2021.0020. 10.1089/nat.2021.0020 Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://www.tandfonline.com/doi/citedby/10.1080/15548627.2020.1797280?scroll=top&needAccess=true. Publicado • 10.1080/15548627.2020.1797280 Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain 143 2 (2019): 407-429. http://dx.doi.org/10.1093/brain/awz328. Acesso aberto • Publicado • 10.1093/brain/awz328 Sónia Patrícia Duarte; Beatriz Estremores; Janete Cunha-Santos; Catarina Miranda; João Barata; Albert La Spada; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". European Journal of Clinical Investigation 49 S1 (2019): 101-221. http://dx.doi.org/10.1111/eci.13109. Publicado • 10.1111/eci.13109 Duarte, Sónia; Estremores, Beatriz; Cunha-Santos, Janete; Miranda, Catarina; Barata, João; La Spada, Albert; De Almeida, Luis. "Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00026. Publicado • 10.3389/conf.fncel.2019.01.00026 Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS. Publicado • 10.1016/j.ymthe.2018.07.007 Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al. "Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy". Cell Metabolism 20 4 (2014): 626-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS. Publicado • 10.1016/j.cmet.2014.09.001 Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al. "Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model". Stem Cells 31 3 (2013): 423-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS. Publicado • 10.1002/stem.1292 Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V.. "Suicide gene therapy in cancer: Where do we stand now?". Cancer Letters 324 2 (2012): 160-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS. Publicado • 10.1016/j.canlet.2012.05.023 Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V.. "Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect". Oncology Reports 28 3 (2012): 1057-1062. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS. Publicado • 10.3892/or.2012.1904 Duarte, S.; Faneca, H.; Lima, M.C.P.D.. "Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo". International Journal of Pharmaceutics 423 2 (2012): 365-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS. Publicado • 10.1016/j.ijpharm.2011.12.035 Duarte, S.; Faneca, H.; Pedroso De Lima, M.C.. "Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum". Journal of Controlled Release 149 3 (2011): 264-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS. Publicado • 10.1016/j.jconrel.2010.10.032 Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana Luísa; Duarte, Sónia; Henriques, Ana; Paiva, Artur; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". The Journal of Gene Medicine 10 11 (2008): 1210-1222. http://dx.doi.org/10.1002/jgm.1247. Publicado • 10.1002/jgm.1247 Duarte, S.P.; Fortes, A.G.; Prazeres, D.M.F.; Marcos, J.C.. "Preparation of plasmid DNA polyplexes from alkaline lysates by a two-step aqueous two-phase extraction process". Journal of Chromatography A 1164 1-2 (2007): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548030710&partnerID=MN8TOARS. Publicado • 10.1016/j.chroma.2007.06.061
Capítulo de livro	Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Polyglutamine Disorders in Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018. Publicado • 10.1007/978-3-319-71779-1_18 Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; Costa, Pedro M; Pereira de Almeida, Luis; Pedroso De Lima, M.C.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Silencing: Theory, Techniques and Applications, 81-110. Nova Science Publishers, 2013. Publicado Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013. 10.1007/978-94-007-6010-3_6
Poster em conferência	A C Silva, C Henriques, D D Lobo, A R Fernandes, M Lopes, D Pereira,; S P Duarte, R Baganha, S M Lopes, M Santana, R J Nobre L Pereira de Almeida. "Allele-specific silencing of mutant ATXN3 rescues motordeficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Trabalho apresentado em 30th ESGCT meeting, 24th-27th October 2023, 2023. Silva, Patrick; Santana, Magda M; Pinto, Maria; Gaspar, Laetitia S; Nobre, Rui Jorge; Duarte, Sónia; Monteiro Marques, Tania; et al. "Discrimitating spinocerebellar ataxia type 3 ataxic mutation carriers from control and pre-ataxic throuh miRNA expression profiles in plasma-derived extracellular vesicles". Trabalho apresentado em EMBO\|EMBL Symposium: The non-coding genome, 2023. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em ESGCT 30th Congress, 2023. Santos, Bárbara; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel,; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P., et al.. "GreenLabsCIBB - One path for sustainable research". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Mendes, Cândida; Marques, Carla; Mota, Sandra I.; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P. et al.. ""Collection Points"-Reuse and Recycling". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Alarico, S., Afonso M., Alves A., Amaral S., Amorim R., Candeias E., Cardoso M., Cortes L., Cruz T., Duarte S.P., Faria ; Gonçalves M., Lavoura N., Léger H., Manadas B., Marques C., Marques C.I., Mele M., Mendes C., Miranda C., Mota S.I., Rib; Romera L., Roxo I. , Santos B., Santiago A.R., Santos D., Sebastião A.I., Simões I.. "GreenLabsCiBB \| One path for sustainable research". Trabalho apresentado em Envisioning the research centres of the future \| EU-LIFE, June 2023, Gulbenkian, 2023. Carina Henriques, Miguel Lopes, Patricia Albuquerque, David Rufino-Ramos, Laetitia Gaspar, Diana Lobo, Ana Carolina Silv; Sónia Duarte, Casey A. Maguire, Magda Santana, Luis Pereira de Almeida, Rui Jorge Nobre. "ISOLATION OF NATURAL AND BIOLOGICALLY ACTIVE EV-AAVs FOR BRAIN GENE DELIVERY". Trabalho apresentado em American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting, May 16-20, 2023 \| Los Angeles, CA, 2023. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Trabalho apresentado em FENS Regional Meeting 2023 (FRM), 2023. Serra, Beatriz; Duarte, Sónia; Françoise, PIGUET; Nathalie Cartier; Alves, Sandro; de Almeida, Luis Pereira; Perfeito, Rita. "Validation of the brain-targeting AAV- PHP.eB encoding cholesterol hydroxylase CYP46A1: a promising non-invasive therapeutic strategy for Spinocerebellar Ataxia Type 3". Trabalho apresentado em FENS Regional Meeting 2023, 2023. Beatriz Guedes, Sónia Duarte, Sandra Morais Cardoso, Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Trabalho apresentado em AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. 28 March-1 April, Gothenburg, Sweden., 2023. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022. D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel, ; L Pereira de Almeida, ; and SP Duarte. Autor correspondente: and SP Duarte. "P231 MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. C Henriques, M Lopes, P Albuquerque, D Rufino-Ramos, L Gaspar, D Lobo, A C Silva, ; R Baganha, S Duarte, C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte,; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre; Maciej Figiel, Luís Pereira de Almeida; Sónia Patrícia Duarte (Presenter). Autor correspondente: Sónia Patrícia Duarte (Presenter). "Investigating microRNA dysregulation towards the development of a microRNA-based therapy for Spinocerebellar ataxia type-3\|Machado-Joseph disease (SCA3\|MJD)". Trabalho apresentado em CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2, 2022. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Autor correspondente: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022. Maria Inês Barros, António da Silva, Inês Martins, Sónia Duarte, Rui Jorge Nobre, Ana Teresa Simões, ; Luís Pereira de Almeida* and Catarina Oliveira Miranda. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Sandra O. Braz, Catarina Vinhas, Daniel Henriques, Ricardo Moreira, Rosário Faro, Sónia Duarte, ; Luis Pereira de Almeida and Liliana S. Mendonça. "Cerebellar transplantation of iPSC-derived neuroepithelial stem cells silenced for mutant ATXN3 for Machado-Joseph disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre, Luis Pereira de Almeida ; Sónia P. Duarte. Autor correspondente: Sónia P. Duarte. "Restoration of dysregulated microRNA levels in a transgenic mouse model of Machado-Joseph disease as a novel therapeutic approach". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Maria Inês Santos, Ana Daniela Oliveira, Maria M. Pinto, Magda M. Santana, Diana Santos, Ana Rita Álvaro,; Luís Pereira de Almeida* ; Sónia P. Duarte. Autor correspondente: Sónia P. Duarte. "miRNA dysregulation in Machado-Joseph disease: what can we learn from human induced pluripotent stem cell-based models?". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Beatriz Serra; Sónia P. Duarte; Nathalie Cartier; Sandro Alves; Luís Pereira de Almeida; Rita Perfeito. "Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non- invasive therapeutic strategy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Ana Carolina Silva, Diana D. Lobo, Carina Henriques, Inês M. Martins, Sara M. Lopes, Sónia P. Duarte, Elizabeth Wagner,; Rui Jorge Nobre* and Lui´s Pereira de Almeida; Equal contribution. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia Patrícia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Trabalho apresentado em 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal, 2021. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, João Barata, Diana Santos,; Maciej Figiel, Albert La Spada, Luis Pereira de Almeida. "MicroRNA profiling in Spinocerebellar ataxia type-3: On the development of a miRNA-based therapy". Trabalho apresentado em NAF's biennial Ataxia Investigators Meeting (AIM 2020)---Postponed to May 24-27, 2021, virtual AIM due to COVID pandemics, 2021. Mendonça Liliana; Daniel Henriques; Vanessa Fernandes; Ricardo Moreira; Ana C. Vinhas; Rosário Faro; Sónia Duarte; et al.. ""Patient specific IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph disease"". Trabalho apresentado em FENS 2020 Virtual Forum (accepted for electronic poster presentation), July 11-15, 2020, 2020. Lodewilk Toonen, Raygene Martier, Rui Nobre, Astrid Valles, Janice Stricker-Shaver,; Jeannette Hübener-Schmid, Sonia Duarte, et al.. "Assessment of the Novel AAV-Based miQURE Gene Therapy in SCA3 Animal Models". Trabalho apresentado em ASGCT 23rd Annual meeting, 2020. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Trabalho apresentado em 3rd BEB Day (2019), 2019. Barros MI; Martins Inês; Duarte, S.P.; Nobre RJ; Simões AT; Miranda CO; Pereira de Almeida L. "Assessing the putative role of mesenchymal stromal cells effectors in Machado-Joseph disease". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019. Ricardo Moreira; Liliana S. Mendonça; Daniel Henriques; Sónia Duarte; et al.. ""Investigation of Mutant Ataxin-3 spreading in Machado-Joseph Disease"". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases". Trabalho apresentado em 5th GEIVEX Symposium, November 6-8, 2019, 2019. Carlos A. Matos; André Conceição; Frederico Pena; Sara Lopes; Duarte, Sónia; Catarina Miranda; Luis Pereira de Almeida. "TRANSCRIPTIONAL REPRESSION OF MUTANT HUMAN ATNX3 USING CRISPR INTERFERENCE MITIGATES THE PATHOLOGICAL PHENOTYPE OF AN IN VIVO MACHADO-JOSEPH DISEASE MODEL". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Liliana S. Mendonça; Ricardo Moreira; Daniel Henriques; Duarte, Sónia; Teresa Rodrigues; Henrique Girão; Jens C. Schwamborn; Luis Pereira de Almeida. "INVESTIGATION OF MUTANT ATAXIN-3 SPREADING IN MACHADO-JOSEPH DISEASE". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Duarte S; et al.. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Miranda, João Barata, Albert La Spada, ; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Miranda CO; Adriana Machado; Silva Teresa P; Barata, J.; Vasconcelos-Ferreira A; Pereira, Dina; Duarte S; et al.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, December 6 - 7th, 2018, 2018. Duarte, Sónia; B Estremores, J Cunha-Santos, C O Miranda, J Barata, A R La Spada, L P de Almeida. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-joseph disease mouse models". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C; Sereno J, Peretrella L, Paiva V, Castelhano J, Nobre R, Gomes C, Castelo-Branco M and de Almeida LP. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. L Mendonça, D Henriques, R Moreira, S Duarte, JC Schwamborn and L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. Miranda C.O., Machado A., Silva T., Barata J., Pereira D., Vasconcelos-Ferreira A., Nóbrega C., Peretrella L.; Sereno J., Castelhano J., Duarte S., Nobre R., Paiva V., Castelo-Branco M. and de Almeida L.P.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), October 12-14, 2017, Covilhã, Portugal., 2017. Duarte, Sónia; Miranda, C.O., Cunha-Santos, J., Barata, J., Estremores, B., La Spada, A.R., de Almeida, L.P.. "Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Trabalho apresentado em International Ataxia Research Conference, September 27-30, 2017, Pisa, Italy., 2017. Miranda C.O., Machado A., Silva T., Barata J., Nóbrega C., Duarte S.; Nobre R., Sereno J., Paiva V., Castelhano J., Castelo-Branco M. and de Almeida L.P. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017. Duarte, Sónia; Catarina Oliveira Miranda, Janete Cunha-Santos, João Barata, Albert R. La Spada, Luís Pereira de Almeida. "Autophagy activation mediated by let-7 alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017. Duarte, Sónia; La Spada A.R., de Almeida L.P.. "Unravelling let-7 role in Machado-Joseph Disease". Trabalho apresentado em XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Trabalho apresentado em Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "A novel folate-associated lipoplex formulation for gene delivery: evaluation of the potential for HSV-tk/valganciclovir suicide gene therapy in vitro and in vivo". Trabalho apresentado em XX Porto cancer meeting, April 28-29, 2011, Porto, Portugal., 2011. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "Development of folate-lipid-based systems for tumor-targeted gene delivery". Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010. Duarte, Sónia; Faneca H., Trabulo S., Cardoso A.L. and Pedroso de Lima M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery". Trabalho apresentado em XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium., 2008. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Gomes P., Simões S., de Lima M.C.. "Association of S413-PV cell penetrating peptide with cationic liposomes: a synergistic effect on the intracellular delivery of plasmid DNA". Trabalho apresentado em 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland., 2008. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., Pedroso de Lima M.C. "S4(13)-PV cell penetrating peptide-based systems for the intracellular delivery of plasmid DNS and siRNA". Trabalho apresentado em V Encontro anual do CNC, December 20-21, 2007, Coimbra, Portugal., 2007. Duarte S., Marcos J.C.. "Quantification of plasmid DNA in the presence of PEGylated polyethyleneimine by hydrophobic interaction chromatography". Trabalho apresentado em 5º Encontro Nacional de Cromatografia, December 10-12, 2007, Aveiro, 2007. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., de Lima M.C.. "Enhancement of the intracellular delivery of siRNA and plasmid DNA using S4(13)-PV cell penetrating peptide-based systems". Trabalho apresentado em 2nd Intracellular Delivery of Therapeutic Molecules – From Concept to Application, September 19-21, 2007, Grenoble, France., 2007. Duarte, Sónia; Fortes A.G., Prazeres D.M.F., Marcos J.C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems". Trabalho apresentado em 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain., 2007. Duarte, Sónia; Barbosa H., Prazeres D.M.F. and Marcos J.C.. "Isolation of DNA Plasmid from Polyethyleneimine Polyplexes in Aqueous Two-Phase Systems". Trabalho apresentado em International Conference on Biopartitioning and Purification (BPP 2005), June 20-24, 2005, Netherlands., 2005.
Resumo em conferência	C Henriques, M Lopes, P Albuquerque, D Rufino?Ramos, L Gaspar, D Lobo, A C Silva, R Baganha, S Duarte; C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Trabalho apresentado em ESGCT 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11–14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts Carlos A. Matos; Frederico Pena; Andre Conceicao; Sara Lopes; Sónia Duarte; et al.. "CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model. MOLECULAR THERAPY (2019) 27 (4): 120-121". Trabalho apresentado em 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019, 2019. Publicado Catarina Oliveira Miranda; Adriana Marcelo; Teresa Pereira Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Sónia Duarte; et al.. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy, In European Journal of Clinical Investigation (2019) 49 (S1): 44-44". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Publicado • 10.1111/eci.13109 C Matos; F Pena; A Conceicao; Lopes S.; Duarte, S.P; et al.. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model, In European Journal of Clinical Investigation (2019) 49 (S1): 86-87". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Publicado • 10.1111/eci.13109 Duarte, Sónia; Beatriz Estremores; Janete Cunha-Santos; Miranda, Catarina; João Barata; AR La Spada; Pereira de Almeida, Luis. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-Joseph disease mouse models, HUMAN GENE THERAPY (2018) 29 (12), A81-A81". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts CO Miranda; A Marcelo; TP Silva; J Barata; A Vasconcelos-Ferreira; D Pereira; S Duarte; et al.. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, HUMAN GENE THERAPY (2018) 29 (12), A56-A56". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts L Mendonça; D Henriques; R Moreira; Sónia Duarte; JC Schwamborn; L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment, HUMAN GENE THERAPY (2018) 29 (12), A66-A66". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts Duarte, S.; de Almeida LP; La Spada, A.R.. "Unravelling let-7 role in Machado-Joseph Disease, In Human Gene Therapy (2016) 27 (11), A1-A185". Trabalho apresentado em XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016. Publicado • 10.1089/hum.2016.29035.abstracts Duarte, S.; Faneca, H.; Pedroso de Lima, M.C.. "Development of folate-lipid-based systems for tumour-targeted gene delivery, In Ejc Supplements (2010) 8 (5): 72-72". Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010. Publicado • 10.1016/s1359-6349(10)71079-x Trabulo, S.; Mano, M; Faneca, H.; Cardoso, A.L.; Duarte, S.; Gomes, P.; Simões, S.; Pedroso De Lima, M.C.. "Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA, In Journal of Peptide Science (2008) 14 (8), 135-135". Trabalho apresentado em 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland, 2008. Publicado • 10.1002/psc.1090 Duarte, S.; Faneca, H.; Trabulo, S.; Cardoso, A.L.; Pedroso de Lima, M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery, Human Gene Therapy (2008) 19 (10): 1153". Trabalho apresentado em XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium, 2008. Publicado • 10.1089/hum.2008.1034 Duarte, Sónia; Fortes, António G.; Prazeres, Duarte. M.; Marcos, João C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems, In Journal of Biotechnology (2007) 131 (2): S6". Trabalho apresentado em 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain, 2007. Publicado • 10.1016/j.jbiotec.2007.07.012
Tese / Dissertação	Duarte, Sónia. "ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20480. Duarte, Sónia. "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato". Licenciatura, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2004.

Artística / Interpretação

Gravação vídeo	Sónia Duarte and Luis Ribeiro; Carolina Caetano (Produtor); Carolina Caetano, Luisa carreira, Susana Alarico and Sara Amaral (Realizador). 2022. Video Reusing/Recycling "Collection points"_GreenLabsCIBB. Social Media networks, namely twitter.
Guião	Carolina Simões; Rita Perfeito; Sónia Duarte; João Cardoso; Luís Pereira de Almeida.. Vale a pena financiar a investigação em doenças raras? - Conteúdo Multimédia "A Saúde no Saber: Um Mito Animado - Episódio 7". https://www.facebook.com/watch/?v=592303805091989. 2021.

Outros

Outra produção

MicroRNA profiling in human cell-based models of Machado-Joseph disease. 2020. Maria Inês Santos, Sónia Patrícia Duarte. http://hdl.handle.net/10316/92999.
The role of autophagy activation-mediated by Let-7 in a transgenic mouse model of Machado-Joseph Disease. 2018. Estremores, Beatriz; Duarte, Sónia Patricia. http://hdl.handle.net/10316/86233.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/02/07	Targeted silencing via AAV9 polycistronic microRNA therapy rescues SCA3 molecular, neuropathological and motor deficits	54th Annual meeting of the Portuguese Pharmacology Society, Lisboa, 7-9 February 2024 NOVA Medical School
2024/02/07	Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Spinocerebellar Ataxia Type 3	54th Meeting of the Portuguese Society of Pharmacology, Lisboa, 7-9 February 2024 NOVA Medical School
2022/10/28	MicroRNAs at the cornerstone of Machado-Joseph Disease pathogenesis: Leveraging disease-associated miRNA dysregulation to develop microRNA-based therapeutics (by invitation)	4th meeting of the CIBB thematic area ‘Innovative Therapies’ Anfiteatro Subunidade 3 \| FMUC, Polo III (Coimbra, Portugal)
2022/06/01	MicroRNA pathway dysfunction in Machado-Joseph disease: implications in pathology and development of a microRNA-based therapy (by Invitation)	DCV.Talks Amphitheatre 1, S. Bento building, Polo 1, Coimbra, Portugal (Coimbra, Portugal)
2022/04/02	Non-invasive delivery of the brain-targeting AAV-PHP.eB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising therapeutic strategy	CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2 Grande Hotel do Luso, Portugal (Luso, Portugal)
2022/02/21	Induced Pluripotent Stem cells derived from Machado-Joseph Disease patients as a promising model to investigate microRNA dysregulation	52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022) ICBAS, Porto, (Portugal)
2022/02/09	Reverting dysregulation of microRNA levels as a promising therapeutic strategy for Machado-Joseph Disease	52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022) ICBAS, Porto (Portugal)
2022/02/09	Assessing the potential of mesenchymal stromal cells for alleviation of blood-brain barrier dysfunction in MachadoJoseph Disease	52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022) ICBAS, Porto (Portugal)
2022/02/09	Validation of the brain-targeting AAVPHPeB enconding cholesterol hydroxylase CYP46A1 as a therapeutic candidate for Spinocerebellar Ataxia Type-3	52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022 (9-11 fevereiro 2022) ICBAS, Porto (Portugal)
2021/04/21	MiRNA dysregulation in Machado-Joseph Disease	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) Center for Neurosciences and Cell Biology (Coimbra, Portugal) (Coimbra)
2021/02/19	IPSC-derived neuroepithelial stem cells depleted for mutant ataxin-3 for Machado-Joseph disease treatment	51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021 Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/19	Phenotypic characterization of neuronal cultures derived from Machado-Joseph disease induced pluripotent stem cells	51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021 Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18	Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics	51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021 Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18	Identification of dysregulated mirnas in human induced pluripotent stem cell-based models of Machado-Joseph disease: one step closer to a therapeutic approach?	51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021 Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2021/02/18	Unravelling dysregulated micrornas in a transgenic mouse model of Machado-Joseph disease	51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, February 17-19, 2021 Faculdade de Farmácia da Universidade de Lisboa. Virtual meeting (Portugal)
2020/10/14	Thinking Small: Towards microRNA-based therapeutics for Machado-Joseph disease (by Invitation)	Neuroscience and Disease Thematic Line Joint DataClub- a forum for discussion Center for Innovative Biomedicine and Biotechnology (CIBB) (Portugal)
2020/03/03	Autophagy-regulation mediated by microRNAs in Neurodegenerative Diseases (by invitation)	American Society for Experimental Neurotherapeutics 2020 (ASENT 2020) American Society for Experimental Neurotherapeutics (Bethesda MD, Washington DC, Estados Unidos)
2020/02/05	CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo	50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Coimbra , Portugal)
2020/02/05	Human IPSC-derived neuroepithelial stem cells for cell-based therapy in Machad-Joseph disease,	50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/12/19	MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? (by invitation)	Center for Innovative Biomedicine and Biotechnology (CIBB) Meeting Center for Innovative Biomedicine and Biotechnology (CIBB) (Coimbra, Portugal)
2019/11/15	Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders	1st Annual Meeting in Pharmaceutical Sciences Pharmaceutical Sciences (Coimbra, Portugal)
2019/11/15	Human iPSC-derived neuroepithelial stem cells as a source for cell therapy in Machado-Joseph disease	1st Annual Meeting in Pharmaceutical Sciences. November 15, 2019, Coimbra, Portugal (Portugal)
2019/11/13	"Mecanismos de doença - da alteração genética à disfunção celular e sua manifestação clínica (by invitation)	Curso Ataxias hereditárias e paraparésias espásticas: da biologia molecular ao tratamento, Pré - Congresso de Neurologia 2019, November 13, 2019, Coimbra, Portugal Sociedade Portuguesa de Neurologia (Coimbra, Portugal)
2019/10/10	Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Lisbon, Portugal)
2019/05/30	Autophagy activation induced by let-7 microrna overexpression counteracts disease phenotype in Machado-Joseph disease mouse models	XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019 Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05/30	Human IPSC-derived neuroepithelial stem cells for cell-based therapies in Machado-Joseph disease	XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019 Portuguese Society for Neuroscience (Lisbon, Portugal)
2019/05/22	CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019 European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05/22	Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sus- tainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy (by invitation)	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019 European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019/05/10	Cerebellar transplantation of human iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment (by invitation)	Neuroscience and Diseases Retreat Center for Innovative Biomedicine and Biotechnology (CIBB) (Miranda do corvo, Portugal)
2019/02/06	Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases	XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019 Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02/06	Human IPSC-derived neuroepithelial stem cells for neuroprotection and neuroregeneration in Machado-Joseph disease	XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019 Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/02/06	Mutant ataxin-3 spreading in Machado-Joseph disease,	XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, February 6-8, 2019 Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2019/01/17	Doenças de expansão de poliglutaminas - Machado-Joseph a ataxia dominante mais comum (by invitation)	Conferências IEC and UNISOB Universidade Sénior de Oliveira do Bairro (UNISOB), an initiative from Instituto de Educação e Cidadania (IEC) in collaboration with UNISOB (Oliveira do Bairro, Portugal)
2018/10/09	Patient-specific iPSC-derived neuroepithelial stem cells for neuroprotection and neuroregeneration in Machado-Joseph disease	10th International Symposium on Neuroprotection and Neurorepair, October 9-11, 2018 Federation of European Neuroscience Societies (Dresden, Alemanha)
2018/03/02	Let-7 microRNA-based therapy alleviates neuropathology, imbalance and motor incoordination in Machado-joseph disease	Congresso da SPDMov 2018 - Genética das Doenças do Movimento, March 2-3, 2018 Sociedade Portuguesa das Doenças do Movimento (SPDMov) (Curia, Portugal)
2018/03/02	Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS	Congresso da SPDMov 2018 - Genética das Doenças do Movimento, March 2-3, 2018 Sociedade Portuguesa das Doenças do Movimento (SPDMov) (Curia, Portugal)
2018/02/05	Let-7 mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease	XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018 Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018/02/05	Microrna dysregulation in machado-joseph disease: from pathogenesis to therapy	XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018 Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018/02/05	Repeated mesenchymal stromal cells treatment sustainably alleviates machado-joseph disease	XLVIII Reunião da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, e XVII Reunião de Toxicologia, February 5-7, 2018 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2017/12/21	Implications of microRNAs dysregulation in Machado-Joseph Disease: From pathogenesis to therapy (by Invitation)	2ND Meeting on Biomedical Research @ UC, December 21st, 2017 (Coimbra, Portugal)
2017/10/12	Human iPSCs-derived NESCs for cerebellar transplantation in Machado-Joseph disease	10th International meeting of the Portuguese society for Stem cells and Cell Therapies, October 12-14, 2017 Portuguese society for Stem cells and Cell Therapies (Covilhã, Portugal)
2017/09/27	Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models	International Ataxia Research Conference, September 27-30, 2017 Ataxia UK, GoFar (Italian organisation) and FARA (American organisation) (Pisa, Itália)
2011/12/19	Efficient gene delivery and potent antitumoral activity in vitro and in vivo mediated by a new folate (FA)-associated lipoplex formulation	IX Annual Meeting - Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine, December 19-20, 2011 Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine (coimbra, Portugal)
2009/12/21	Non-covalent strategies combining cationic lipids and CPPs to enhance the delivery of nucleic acids – looking at cellular internalization and biological activity	VII Annual Meeting - Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine, December 21-22, 2009 Center for Neurosciences and Cell Biology & Doctoral Programme in Biology and Experimental Biomedicine (Cantanhede, Portugal)
2009/09/03	Folate receptor-targeting delivery of lipid-based systems aiming at cancer gene therapy	GTRV- Summer School «Targeted Drug Delivery», September 3-4, 2009 (Lausanne, Suiça)
2009/08/31	Optimization of S4(13)-PV cell penetrating peptide-based vectors for the delivery of nucleic acids – study of cellular internalization and biological activity	3rd Intracellular Delivery of Therapeutic Molecules: From Bench to Bedside, August 31-September 2, 2009 (Montpellier, França)
2008/08/30	S413-PV cell penetrating peptide associated with different cargos: assessment of delivery efficiency and internalization mechanisms	Cell-Penetrating Peptides Satellite Symposium of the 30th European Peptide Symposium, August 30-31, 2008 European Peptide Society (EPS) and the Finnish Peptide Society (FIPS) (Helsinki, Finlândia)
2006/08/27	Simultaneous purification and condensation of plasmid DNA with PEGylated Polyethyleneimine in Aqueous Two-Phase Systems	6th European Symposium on Biochemical Engineering Science (ESBES 6) \| August 27 - 30, 2006 European Society of Biochemical Engineering Sciences (Salzburg, Áustria)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2020/09 - Atual	Thesis: Unravelling microRNA dysregulation in Machado-Joseph Disease models (Co-supervisor Luis Pereira de Almeida, PhD) Orientador de José Miguel Amaral Pinto	Master in Pharmaceutical Biotechnology (Mestrado)
2022/09 - 2024/03/19	Thesis: Identify miRNA-specific small molecules capable of selectively modulate miRNA levels (Co-supervisor Luis Pereira de Almeida, PhD) Orientador de Micaela Figueiredo Pintor	Master in Pharmaceutical Biotechnology (Mestrado) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2022/02/16 - 2023/02/15	Supervision of MSc Research fellow hired under the project funded by AFM 23755 entitled "Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)" Orientador de Maria Inês Nunes dos Santos	Center for Neurosciences and Cell Biology, Portugal
2019/07/01 - 2022/02/28	Supervisor of the Post-Doctoral Researcher hired for the project funded by FCT (POCI-01-0145-FEDER-032309) entitled "Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy". Orientador de Diana Isabel da Silva Santos	Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/04/05 - 2021/10/04	Supervision of MSc Research fellow hired under the project funded by FCT (POCI-01-0145-FEDER-032309) entitled "Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy" Orientador de Maria Inês Nunes dos Santos	Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/09/02 - 2020/12/16	Thesis: MicroRNA profiling in human cell-based models of Machado-Joseph disease (Co-supervisor Luis Pereira de Almeida, PhD) Orientador de Maria Inês Nunes dos Santos	Master in Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09 - 2018/09/26	Thesis: The role of autophagy activation mediated by Let-7 in a transgenic mice model of Machado-Joseph Disease (Co-supervisor Carlos B. Duarte) Orientador de Beatriz Filipa Varela Estremores	Master in Molecular and Cell Biology, University of Coimbra (Mestrado) Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/09 - 2016/09/09	Thesis: Autophagy deregulation in models of Parkinson's disease and Machado-Joseph disease (Co-supervisors Rita Perfeito, PhD and Luis Pereira de Almeida, PhD) Orientador de Chiara Soricelli	Master in Molecular and Cell Biology, University of Coimbra (Mestrado) Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2008 - 2009	Supervision of the project student/scientific internship Orientador de Cláudia Pinho	Bachelor Degree in Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal
2007 - 2008	Co-supervision of the project student/scientific internship under the topic "Development of antisense oligonucleotides delivery systems for splice correction" Coorientador de Sara Varela Amaral	Degree in Biochemistry (Licenciatura/Bacharelato) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2006 - 2006	Participation in the Organization of the International Symposium: Agents for Molecular therapy: Preparation and applications, September 15th, 2006 in the School of Sciences, University of Minho, Braga (2006/09/15) Simpósio (Membro da Comissão Organizadora)	Universidade do Minho, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2023/01/10 - 2023/01/10	Participating as Doctoral investigator in the Conference "Ética, Integridade e Transparência", January 10th, 2023, Auditório da Reitoria, University of Coimbra. Conferência	Conference "Ética, Integridade e Transparência" Universidade de Coimbra, Portugal
2022/12/19 - 2022/12/19	Participating as Doctoral investigator in Encontro CIBB 2022 I CIBB Meeting 2022 at the Auditório da Unidade Central do Polo III Encontro	Encontro CIBB 2022 I CIBB Meeting 2022 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2022/11/19 - 2022/11/19	Participating as Doctoral Investigator in the Event with MJD patients, INICIATIVA EUROPEIA para a Doença de Machado-Joseph: Passado, Presente e Futuro, November 19th, 2022, Exploratório, Coimbra Encontro	INICIATIVA EUROPEIA para a Doença de Machado-Joseph: Passado, Presente e Futuro Exploratório, Portugal
2022/09/30 - 2022/09/30	Participated as Doctoral Investigator in the activity "To be or not to be a GreenLab \| Que tipo de plástico sou?, Less plastic, more planet!", European Researchers'Night, September 30, 2022, Baixa de Coimbra. https://noiteeuropeiadosinvestigadores.uc.pt/ https://www.facebook.com/photo/?fbid=10160084047153908&set=a.436047723907 Exposição	European Researchers' Night Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra, Portugal
2021/12/20 - 2021/12/20	Participting as a Doctoral Researcher in the CIBB MEETING 2021 (Online via Zoom) Encontro	CIBB MEETING 2021 Center for Neurosciences and Cell Biology, Portugal
2021/11/24 - 2021/11/24	Participated as Doctoral Investigator in the activity of Science communication "Falando sobre o cérebro e construção de neurónios" for students at primary school of Bairro Norton de Matos. Event: https://www.facebook.com/media/set/?set=a.607551827328220&type=3 Exposição	Semana da Ciência e Tecnologia 2021 Center for Neurosciences and Cell Biology, Portugal
2021/11/17 - 2021/11/18	Participting as Doctoral Investigator in the "2nd Retreat of CIBB's Metabolism, Aging and Disease Area". (Both live and virtual) Encontro	2nd Retreat of CIBB's Metabolism, Aging and Disease Area Center for Neurosciences and Cell Biology, Portugal
2021/05/24 - 2021/05/25	Participating as Doctoral Investigator in the 3rd CIBB Neuroscience and Disease retreat (Online via Zoom) Encontro	3rd CIBB Neuroscience and Disease retreat Center for Neurosciences and Cell Biology, Portugal
2021/01/20 - 2021/01/20	Participating as Doctoral Investigator in the Joint DataClub of Neuroscience and Disease Thematic Line Conferência	Neuroscience and Disease Thematic Line- Joint DataClub Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/10/14 - 2020/10/14	Participating as Doctoral Investigator in the event "O Cérebro e Ambiente: O Impacto da Pandemia" Seminário	"O Cérebro e Ambiente: O Impacto da Pandemia" Center for Neurosciences and Cell Biology, Portugal Universidade do Algarve Centro de Investigação em Biomedicina, Portugal Sociedade Portuguesa de Neurociências, Portugal
2020/09/19 - 2020/09/19	Participating as Doctoral Investigator in the 2nd CIBB INNOVATIVE THERAPIES RETREAT 2020 Conferência	2nd CIBB INNOVATIVE THERAPIES RETREAT 2020 Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/07/08 - 2020/07/08	Participating as Doctoral Investigator in the CIBB Neuroscience and Disease Online Retreat Encontro	CIBB Neuroscience and Disease Online Retreat Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/02/29 - 2020/02/29	Participation as Doctoral investigator in the event "Doença de Machado-Joseph: do Laboratório para a Sociedade, 2ª Edição" at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, February 29th 2020. Encontro	“Doença de Machado-Joseph: do Laboratório para a Sociedade, 2ª Edição” Center for Neurosciences and Cell Biology, Portugal
2019/10/04 - 2019/10/04	Workshop: How to write a Great Research Paper, and Get it Accepted by a Good Journal. Oficina (workshop)	How to Get Published Elsevier Ltd, Reino Unido
2019/10/03 - 2019/10/03	Workshop: First Aid Course \| Formação em primeiros socorros Oficina (workshop)	First Aid Course provided by HIORSE (Hygien, Safety and Health at Work, LDA) CNC.IBILI, Portugal
2019/09/27 - 2019/09/27	Participation as Doctoral investigator in the initiative European Researcher's night at the Jardim Botânico of University of Coimbra, September 27 2019. Outro	“European Researcher’s night” Universidade de Coimbra, Portugal
2019/09/26 - 2019/09/26	Workshop: AniBio Software Oficina (workshop)	AniBio Software Center for Neurosciences and Cell Biology, Portugal
2019/05/13 - 2019/05/13	Participation as Doctoral Investigator in the initiative "Escola Ciência Viva" at the Rómulo centro de Ciência viva of University of Coimbra, May 13rd 2019. Outro	“Escola Ciência Viva” Rómulo Centro de Ciência Viva da Universiade de Coimbra, Portugal
2019/05/10 - 2019/05/10	Participating as Doctoral Investigator in the CIBB Neuroscience and Disease 1st Retreat, Miranda do Corvo, Portugal. Encontro	CIBB Neuroscience and Disease 1st Retreat Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2012 - 2019	Participation as a Post-Doc Researcher in scientific divulgation related activities as part of the programmes "Brain Awareness Week" from 2012 - 2019. Outro	“Brain Awareness Week” Center for Neurosciences and Cell Biology, Portugal
2012 - 2019	Participation as a Post-Doc Researcher in scientific divulgation related activities as part of the programme "National Science and Technology week" from 2012 - 2019. Outro	“National Science and Technology week” Center for Neurosciences and Cell Biology, Portugal
2018/03/23 - 2018/03/23	Overcoming Challenges in Scientific Careers, Biomedical Research Post-Doctoral Forum @ UC, March 23rd, 2018, Faculty of Medicine- Polo III, University of Coimbra. Simpósio	“Overcoming Challenges in Scientific Careers”, Biomedical Research Post-Doctoral Forum Universidade de Coimbra, Portugal
2018/02/28 - 2018/02/28	Participating as Doctoral Investigator in the event with MJD patients "Doença de Machado-Joseph: do Laboratório para a Sociedade" at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, February 28th 2018. Encontro	“Doença de Machado-Joseph: do Laboratório para a Sociedade” Center for Neurosciences and Cell Biology, Portugal
2017/05/22 - 2017/05/23	Participating as Post-Doc researcher in the 2nd EU joint Programme-Neurodegenerative Disease research (JPND) - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) Meeting, Coimbra, Portugal Conferência	2nd EU joint Programme-Neurodegenerative Disease research (JPND) - European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) Meeting Center for Neurosciences and Cell Biology, Portugal EU Joint Programme Neurodegenerative Disease Research, Alemanha
2016/12/19 - 2016/12/20	Participating as Post-Doc researcher in the 1st meeting on Biomedical research at UC, Polo III Auditorium, University of Coimbra, Portugal. Encontro	1st meeting on Biomedical research Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2016/11/18 - 2016/11/19	Participating as Post-Doc researcher in the Brain With]Out[Borders, Museu da Ciência, University of Coimbra, Portugal. Encontro	Brain With]Out[Borders, Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/04 - 2015/02/06	Participating as Post-Doc researcher in the TreatPolyQ Final Meeting, Museum, Coimbra, Portugal. Conferência	TreatPolyQ Final Meeting Center for Neurosciences and Cell Biology, Portugal
2012/12/04 - 2012/12/06	Advanced Fluorescence Microscopy Workshop at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, 4-6 December 2012. Oficina (workshop)	Advanced Fluorescence Microscopy Workshop Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008 - 2012	Participation as a PhD student in scientific divulgation related activities as part of the programme "Brain Awareness Week" from 2008 - 2012. Outro	“Brain Awareness Week" Center for Neurosciences and Cell Biology, Portugal
2008 - 2012	Participation as a PhD student in scientific divulgation related activities as part of the programme National Science and Technology week from 2008 - 2012. Outro	“National Science and Technology week” Center for Neurosciences and Cell Biology, Portugal
2009 - 2009	Participation as PhD student researcher in the event Cientistas ao Palco during the Researchers' Night international initiative (2009). Outro	“Cientistas ao Palco” during the “Researchers’ Night 2009” international initiative Center for Neurosciences and Cell Biology, Portugal
2005/02 - 2006/02	Participation in the public initiative "Portas Abertas do Departamento de Química- Organização de actividades de divulgação científica", organized by the Biological Chemistry group in February 2005, University of Minho, Braga	"Portas Abertas do Departamento de Química- Organização de actividades de divulgação científica" Universidade do Minho, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/03/19	Identifying Mirna-Specific Small Molecules Capable of Selectively Modulate Mirna Levels in Machado-Joseph Disease Models Orientador	Micaela Figueiredo Pintor (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2020/12/16	Thesis tilte "MICRORNA PROFILING IN HUMAN CELL-BASED MODELS OF MACHADO-JOSEPH DISEASE" Orientador	Maria Inês Nunes dos Santos (Mestrado) Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09/26	Thesis title "The role of autophagy activation mediated by Let-7 in a transgenic mice model of Machado-Joseph Disease" Orientador	Beatriz Filipa Varela Estremores (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/03/21	Thesis title "Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease" Arguente	Udaya Geetha Vijayakumar (Doutoramento) Universidade de Coimbra, Portugal
2016/09/28	Thesis title "MicroRNA based therapeutic approaches for obesity" Arguente principal	Ana Rita Carvalho Samões (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/09	Thesis title "Autophagy deregulation in models of Parkinson's disease and Machado-Joseph disease" Orientador	Chiara Soricelli (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2013/07 - Atual	Acta Neuropathologica (ANP-D-13-00404)	Springer

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2022/04/13 - 2022/04/13	Lecture on the topic "Thinking small: miRNA-mediated gene silencing and miRNA-based therapeutic approaches"	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)	Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra, Portugal
2021/04/21 - 2021/04/21	Lecture on the topic "Thinking small: miRNA-mediated gene silencing and miRNA-based therapeutic approaches"	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)	Center for Neurosciences and Cell Biology, Portugal
2020/12/11 - 2020/12/11	Lecture on the topic "Papel regulador dos microRNAs na expressão génica"	Gene and Cell Therapy course of the graduation in Biomedical Sciences (Licenciatura)	Universidade do Algarve - Campus de Gambelas, Portugal
2020/10/07 - 2020/10/07	Lecture on the topic "Thinking Small: Towards microRNA-based therapeutics"	Summer Course Metodologias de Investigação Científica (Curso Não Conferente de Grau do IIIUC)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/04/04 - 2020/04/04	Lecture on the topic "Papel regulador dos microRNAs na expressão génica"	MÓDULO VIII: TERAPÊUTICA MOLECULAR E ENGENHARIA DE TECIDOS of the Master Course of Pharmaceutical Biotechnology (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/11/26 - 2019/11/26	Lecture on the topic "Autophagy in Machado-Joseph Disease"	Curso de Regulação Celular in the Biomedical Investigation Master (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal CNC.IBILI, Portugal
2019/04/23 - 2019/04/23	Lecture on the topic "MicroRNAs-mediated gene silencing in Neurodegenerative disorders"	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/30 - 2019/03/30	Lecture on the topic "Papel regulador dos microRNAs na expressão génica"	Módulo VIII: Terapêutica Molecular e Engenharia de tecidos of the Master Course of Pharmaceutical Biotechnology (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/05/08 - 2018/05/08	Lecture on the topic "MicroRNAs-mediated gene silencing in Neurodegenerative disorders"	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	Center for Neurosciences and Cell Biology, Portugal
2018/04/21 - 2018/04/21	Lecture on the topic "Papel regulador dos microRNAs na expressão génica"	Módulo VIII: Terapêutica Molecular e Engenharia de tecidos in the Pharmaceutical Biotechnology Master (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09/26 - 2017/10/06	Lecture on the topic "Stereotaxic surgery"	Course of Sciences in Laboratory Animals-Module 21: “advanced anaesthesia for surgical or prolonged procedures in mice and rats” and Module 22: “Principles of surgery (skills)” (Curso de Especialização Tecnológica)	CNC.IBILI, Portugal
2017/03/25 - 2017/03/25	Lecture on the topic "Papel regulador dos microRNAs na expressão génica"	Módulo VIII: Terapêutica Molecular e Engenharia de tecidos in the Pharmaceutical Biotechnology Master (Mestrado)	Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/06/16 - 2016/06/16	Lecture on the topic "Let-7 activates autophagy and alleviates Machado-Joseph Disease"	Advanced Therapies in the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/10 - 2012/10	Lecture on the topic "Western Blot and Immunohistochemistry"	Doctoral Programme in Health Sciences (Doutoramento)	Universidade de Coimbra Faculdade de Medicina, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2021/11/24	"Falando sobre o cérebro e construção de Neurónios" at Primary school of Bairro Norton de Matos	3.ª edição do "Bairrinho Notícias"

Entrevista / Programa (rádio / tv)

	Programa	Tema
2017/09/28 - Atual	Interviewed at #IARC2017 under the program International public promotion in Friedreich's Ataxia News, BioNews Services, LLC, of the research projects ongoing	#IARC2017 – MicroRNA Delivered to Brain Seen to Ease Neurological and Motor Problems in Machado-Joseph Mouse Model

Membro de associação

	Nome da associação	Tipo de participação
2019 - Atual	Sociedade Portuguesa de Neurociências (SPN) membership	Society membership
2019 - Atual	FENS (Federation of European Neuroscience Societies)
2016 - Atual	European Society of Gene and Cell Therapy (ESGCT) Academic Membership	Society membership
2008 - Atual	Portuguese Biochemical Society (SPB) Membership	Society Membership

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2023/12/07 - 2023/12/07	President of the Jury for the assignment of a Research Fellowship \| IT137-23-392, under the project REPURPOSING FDA-APPROVED DRUGS AS MICRORNASPECIFIC MODIFIERS TOWARDS A NEW AND PROMISING THERAPEUTIC APPROACH FOR MACHADO JOSEPH DISEASE/SPINOCEREBELLAR ATAXIA TYPE 3 (MJD/SCA3)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2022/01/27 - 2022/01/27	President of the Jury for the assignment of a Master Researcher Fellowship (BI - AFM 23755 \| Lugus 780589)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Center for Neurosciences and Cell Biology, Portugal
2021/02 - 2021/02	President of the Jury for the assignment of a Master Researcher Fellowship (BI - Atividades de I&D a realizar por estudantes de doutoramento ou mestres inscritos em cursos não conferentes de grau académico_BI: 032309)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/07/28 - 2020/07/28	Jury member for the assignment of Twelve Research Fellowships (BI- Curso de Verão "Metodologias de investigação científica - I&D: Terapia génica e células estaminais" \| 12 BI \| Lugus 685385)	Universidade de Coimbra, Portugal
2020/07/28 - 2020/07/28	Jury member for the assignment of a Initiation Research Fellowship (BII-Curso de Verão "Metodologias de investigação científica - I&D: Terapia génica e células estaminais" \| 1 BII \| Lugus 685393	Universidade de Coimbra, Portugal
2019/11/19 - 2019/11/19	Jury member for the assignment of an MSc researcher fellowship (BIM POCI-01-0145-FEDER-030737)	Center for Neurosciences and Cell Biology, Portugal
2019/05/06 - 2019/05/06	Jury member of an International selection tender procedure for Doctorate hiring (INV JR 2019 Nº 45. 032309)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/03/15 - 2019/03/15	Jury member in the application for Master fellowship with reference BIM 7.3, under the project BrainHealth 2020 - Detecção Precoce, Neuromodulação e Terapias Avançadas para Neuropatologias (CENTRO-01-0145-FEDER-000008)	Center for Neurosciences and Cell Biology, Portugal
2018/11/19 - 2018/11/19	Jury member in the application for Master fellowship with reference BIM POCI-01-0145-FEDER-030737	Center for Neurosciences and Cell Biology, Portugal

Tutoria

	Tópico	Nome do aluno
2020/08 - 2020/10	Mentoring and Evaluation in the Summer Course "Metodologias de investigação científica - I&D: Terapia génica e células estaminais"	Maria Inês Nunes dos Santos
2019/07 - 2019/09	Mentoring of Laboratory Rotation	Maria Inês Nunes dos Santos
2019/04/11 - 2019/07/21	Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology	Maria Inês Nunes dos Santos
2019/04 - 2019/07/12	Mentoring and Evaluation of Thesis Project Defense "MicroRNA profiling in Machado-Joseph Disease-On the development of a New Therapeutic Strategy"	Maria Inês Nunes dos Santos
2019/04 - 2019/06	Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology	Maria Pinto
2019/04 - 2019/06	Mentoring of Lab rotation of Master in Pharmaceutical Biotechnology	Ana Daniela Oliveira
2018/09 - 2019/02	Mentoring of Labrotation of Master in Pharmaceutical Biotechnology	José Miguel Amaral Pinto
2017/07/05 - 2017/07/28	Mentoring and Evaluation of the Seminar in Neurobiology I	Beatriz Filipa Varela Estremores
2017/07/01 - 2017/07/14	Mentoring of the Seminar in Neurobiology II	Beatriz Filipa Varela Estremores
2017/06/05 - 2017/06/30	Mentoring of Laboratory Rotation III of Master in Molecular and Cell Biology, University of Coimbra	Beatriz Filipa Varela Estremores
2017/01/30 - 2017/02/24	Mentoring of Laboratory Rotation I of Master in Molecular and Cell Biology, University of Coimbra	Beatriz Filipa Varela Estremores
2008 - 2009	Laboratory co-supervision of a project student	Liliana Antunes
2008 - 2009	Laboratorial co-supervision of a project student (Bachelor Degree in Biochemistry, Faculty of Science and Technology, University of Coimbra, Portugal)	Joana Guedes

Distinções

Prémio

2021	NAF Young Investigator Award 2021 National Ataxia Foundation, Estados Unidos
2021	AFM Trampolin Grant - 23755 AFM-Téléthon, França
2020	Travel Stipend awarded poster presenter to attend Ataxia Investigators Meeting (AIM) 2020 National Ataxia Foundation, Estados Unidos
2012	Post-Doc fellowship (SFRH / BPD / 87552 / 2012) under a highly competitive application Fundação para a Ciência e a Tecnologia, Portugal
2008	PhD fellowship (SFRH/BD/39727/2007) under a highly competitive application Fundação para a Ciência e a Tecnologia, Portugal
2003	Fellowship under PRODEPIII-estágios 2003/2004 Universidade de Coimbra, Portugal

Outra distinção

2019	PhD/Doctoral Research contract under DL 57/2016 (NT CNC 2018.01-35, position 8) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Fundação para a Ciência e a Tecnologia, Portugal
2018	PhD/Doctoral Research contract under the project POCI-01-0145-FEDER-032309 Fundação para a Ciência e a Tecnologia, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017	Work selected to be disseminated in Friedreich’s Ataxia News, BioNews Services, LLC "#IARC2017 – MicroRNA Delivered to Brain Seen to Ease Neurological and Motor Problems in Machado-Joseph Mouse Model."
2012	Research Fellowship under the project PTDC/SAU-FAR/116535/2010 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007	Research Fellowship under the project PTDC/BIO/65627/2006 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005	Research Fellowship under the Project POCTI BIO/47245/2002 Universidade do Minho, Portugal