Identificação pessoal

Nome completo

Sónia Patrícia Dias Duarte

Nomes de citação

• Duarte, S.P.
• Duarte S.
• Sónia P. Duarte

Identificadores de autor

Ciência ID

CD1E-CEC0-AFFC

Endereços de correio eletrónico

• sonia.duarte@cnc.uc.pt (Profissional)

Telefones

Telefone

• 239820190 (Profissional)

Moradas

• Centro de Inovação em Biomedicina e Biotecnologia (CIBB)/Centro de Neurociências e Biologia Celular (CNC). Universidade de Coimbra, Rua Larga, Faculdade de Medicina Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

• https://cibb.uc.pt/research/innovative-therapies/vectors-gene-cell-therapy/ (Profissional)
• https://www.cnc.uc.pt/pt/people/s-duarte (Profissional)
• https://www.researchgate.net/profile/Sonia-Duarte-3 (Académico)
• https://www.linkedin.com/in/sonia-duarte-0760b219/ (Rede social)

	Grau	Classificação
2023/03/08 - 2023/03/08 Concluído	Webinar on Enabling and advancing mRNA-LNP medicines from concept to clinic (VACCINE INSIGHTS) (Outros) Bioinsights Publishing, Reino Unido
2023/03/01 - 2023/03/01 Concluído	Webinar on Optimize your mRNA process from pDNA template to LNP encapsulation (CELL & GENE THERAPY INSIGHTS) (Outros) Bioinsights Publishing, Reino Unido
2020/06/18 - 2020/06/18 Concluído	X-omics workshop: data standards and multi-omics data integration (Outros) X-omics Organization, Países Baixos
2020/06/10 - 2020/06/10 Concluído	Workshop: "QIAGEN miRNA solutions" (Outros) QIAGEN LLC, Estados Unidos
2019/06/12 - 2019/06/12 Concluído	Workshop: "Everything you need to know about miRNA qPCR" (Outros) QIAGEN LLC, Estados Unidos
2013/02/01 - 2018/07/04 Concluído	Investigating the role of the Let-7 microRNA in Machado-Joseph disease (Pós-doutoramento) Especialização em Neurosciences Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	N/A
2015/07/16 - 2015/07/16 Concluído	Workshop: Bioestatística para trabalhos de investigação (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2015/02/05 - 2015/02/06 Concluído	Neuroepigenetics Advanced course of BEB PhD programme (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014 - 2014 Concluído	Course in laboratory animal science- category B + Certificate of Researcher-coordinator for the practice of animal experimentation (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal Direcção-Geral de Alimentação e Veterinária, Portugal
2013/01/15 - 2013/01/17 Concluído	Workshops at the Biogenesis and turnover of small RNAs meeting from Biochemical Society, Advancing Molecular Bioscience (Outros) Biochemical Society, Reino Unido Royal Society of Edinburgh, Reino Unido
2008/03/01 - 2012/07/24 Concluído	PhD in Biochemistry (Doutoramento) Especialização em Biochemical Technology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "On the development of antitumoural therapeutic strategies: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination" (TESE/DISSERTAÇÃO)	PhD with distinction and honors approved by unanim
2009/10 - 2010/07 Concluído	Advanced Communication Skills in English I and II (Outros) Universidade de Coimbra Faculdade de Letras, Portugal
2010/04 - 2010/06 Concluído	Curso de Formação Inicial de Formadores to acquire the CAP certificate (106 h) (Outros) Tecla Center, Portugal
2010/03/04 - 2010/03/05 Concluído	Workshop: "RNA Therapeutics" (Outros) Harvard Medical School, Estados Unidos Fundação Calouste Gulbenkian, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009/09/03 - 2009/09/04 Concluído	GTRV- Summer School « Targeted Drug Delivery » (Outros) École Polytechnique Fédérale de Lausanne, Suiça
2005/02/22 - 2005/02/25 Concluído	Advanced Course on Gene Therapy (Outros) Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2000/09 - 2004/07/23 Concluído	Biochemistry (Licenciatura) Especialização em Biochemistry Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato" (TESE/DISSERTAÇÃO)	Final grade of 16 (out of 20).

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/09/01 - Atual	Assistente de Investigação (carreira) (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2019/02/01 - 2023/08/31	Investigador Contratado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/07/05 - 2019/01/31	Investigador Contratado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/02/01 - 2018/07/04	Pós-doutorado (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2012/06/01 - 2012/12/31	Pós-doutorado (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2008/03/01 - 2012/07/24	Investigador (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2011/05/01 - 2011/08/05	Investigador visitante (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Centre National de la Recherche Scientifique (UMR 6235 CNRS), França
2010/09/06 - 2010/12/20	Investigador visitante (Investigação)	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Centre National de la Recherche Scientifique (UMR 6235 CNRS), França
2007/06/01 - 2008/02/29	Investigador (Investigação)	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2005/01/01 - 2007/05/31	Investigador (Investigação)	Universidade do Minho, Portugal
	Universidade do Minho, Portugal
2003/09/01 - 2004/07/31	Estagiário de Investigação (Investigação)	Laboratorios Basi S.A.-Industria Farmaceutica, Portugal
	Laboratorios Basi S.A.-Industria Farmaceutica, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2023/04/05 - 2023/09/01	CAREER BREAK: Maternity Leave: Coimbra, Portugal	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
	Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal
2014/07/01 - 2015/01/01	CAREER BREAK: Pregnancy/Maternity Leave: Coimbra, Portugal	Foundation for Science and Technology (Lisbon, Portugal) , Portugal
	Center for Neurosciences and Cell Biology, Portugal

Bolsa

	Designação	Financiadores
2023/03/01 - Atual	Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism 2022.04788.PTDC Investigador	Fundação para a Ciência e a Tecnologia Em curso
2023/01/01 - Atual	Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3 2022.06127.PTDC Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/09/01 - 2024/02/28	MicroRNA-specific small molecule modifiers as a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3) NAF Young Investigator Award Investigador responsável Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	National Ataxia Foundation Em curso
2021/09/16 - 2024	"Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)" Trampoline Grant 23755 Investigador responsável Center for Neurosciences and Cell Biology, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	AFM-Téléthon Em curso
2018/07/06 - 2022/04/05	Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy POCI-01-0145-FEDER-032309 Investigador responsável Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Comissão de Coordenação e Desenvolvimento Regional do Centro Em curso
2020 - 2022/02/28	Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy 686213 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	National Ataxia Foundation
2019 - 2021/12	Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (International Consortium) E-Rare-3 JTC 2017 (International Consortium) Investigador CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2018/06 - 2021/06	The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease POCI-01-0145-FEDER-030737 Investigador Center for Neurosciences and Cell Biology, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Fundação para a Ciência e a Tecnologia Em curso
2017/01 - 2020/12	BRAIN HEALTH 2020-Detecção Precoce,Neuro-modulação e TerapiasAvançadas para Neuropatologias CENTRO-01-0145-FEDER-000008 Investigador Center for Neurosciences and Cell Biology, Portugal	Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE) Foundation for Science and Technology (Lisbon, Portugal) Em curso
2016/04 - 2020/05	ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7) JPCOFUND/0005/2015 (International Consortium) Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	EU Joint Programme Neurodegenerative Disease Research
2016 - 2020/05	JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative JPCOFUND/0001/2015-ESMI (International Consortium) Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	EU Joint Programme Neurodegenerative Disease Research Em curso
2017/03/27 - 2020/03/26	LifeSciences ByCENTRO CENTRO-01-0246-FEDER-000011 Investigador CNC.IBILI, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)
2016/04 - 2019/03	Gene repair and repression strategies to alleviate Machado-Joseph disease PTDC/NEU-NMC/0084/2014 Investigador Center for Neurosciences and Cell Biology, Portugal	Foundation for Science and Technology (Lisbon, Portugal) Concluído
2015/03 - 2018/12	Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases JPND SynSpread: CD/0001/2013 (International consortium) Investigador Center for Neurosciences and Cell Biology, Portugal	EU Joint Programme Neurodegenerative Disease Research Foundation for Science and Technology (Lisbon, Portugal) Concluído
2013/02/01 - 2018/07/04	Investigating the role of the Let-7 microRNA in Machado-Joseph disease SFRH/BPD/87552/2012 Bolseiro de Pós-Doutoramento Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2016/02	Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration E-Rare4/0003/2012 (International consortium) Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2015/08	Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease PTDC/BIM-MEC/0651/2012 Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/03 - 2015/06	Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery PTDC/DTP-FTO/0265/2012 Investigador Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012/06 - 2012/12	Non-invasive Non-viral Silencing of Machado-Joseph disease PTDC/SAU-FAR/116535/2010 Bolseiro de Investigação Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/03/01 - 2012/03/01	ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination SFRH/BD/32797/2007 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/06 - 2008/02	Development of a novel approach for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids PTDC/BIO/65627/2006 Bolseiro de Investigação Center for Neurosciences and Cell Biology, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/01 - 2007/05	Preparação de agentes para Terapia Molecular por purificação e condensação simultânea de plasmídeos em sistemas de duas fases aquosas POCTI BIO/47245/2002 Bolseiro de Investigação Universidade do Minho, Portugal	Universidade do Minho Concluído

Projeto

	Designação	Financiadores
2020/07 - Atual	"miRSilencing" project international collaborative project between the Center for Neuroscience and Cell Biology (CNC, UC, Portugal) and PTC Therapeutics (USA) Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal	PTC Therapeutics Inc Em curso
2018/05 - Atual	"Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs International collaborative project between CNC and Wave Life Sciences USA, Inc Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Wave Life Sciences USA, Inc Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/01/01 - 2023/12/31	Center for Innovative Biomedicine and Biotechnology UIDB/04539/2020 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2019/02 - 2019/10	Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA International Collaborative Project between CNC and uniQure Company Investigador Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	uniQure NV Concluído
2015/01 - 2017/12	“CNC. IBILI” UID/NEU/04539/2013 Investigador Center for Neurosciences and Cell Biology, Portugal	Foundation for Science and Technology (Lisbon, Portugal) Concluído

Outro

	Designação	Financiadores
2018 - Atual	Lab management (organizing/ordering/managing the lab products, space/people in the lab) LAB MANAGMENT Outra Center for Neurosciences and Cell Biology, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso
2013 - Atual	Collaboration with La Spada AR, who first discovered polyglutamine disorders at the University of Duke INTERNATIONAL NETWORK Investigador Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso

Publicações

Artigo em jornal	Ana Catarina Vinhas; Ana Cristina Ferreira; Carina Henriques; Carolina Silva; et al.. "DOENÇAS RARAS: Uma viagem rara - Cartoon created on purpose for the Journal "THE PUBLIC" to explain a rare disease that affects many Portuguese, Machado-Joseph disease.", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Artigo em revista	Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira. "Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-53542-x. Publicado • 10.1038/s41598-024-53542-x Nobre, Rui Jorge; Lobo, Diana D.; Henriques, Carina; Duarte, Sonia P.; Lopes, Sara M.; Silva, Ana C.; Lopes, Miguel M.; et al. "miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics 32 3 (2022): 194-205. http://dx.doi.org/10.1089/nat.2021.0020. 10.1089/nat.2021.0020 Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): https://www.tandfonline.com/doi/citedby/10.1080/15548627.2020.1797280?scroll=top&needAccess=true. Publicado • 10.1080/15548627.2020.1797280 Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain 143 2 (2019): 407-429. http://dx.doi.org/10.1093/brain/awz328. Acesso aberto • Publicado • 10.1093/brain/awz328 Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS. Publicado • 10.1016/j.ymthe.2018.07.007 Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al. "Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy". Cell Metabolism 20 4 (2014): 626-638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS. Publicado • 10.1016/j.cmet.2014.09.001 Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al. "Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model". Stem Cells 31 3 (2013): 423-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS. Publicado • 10.1002/stem.1292 Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V.. "Suicide gene therapy in cancer: Where do we stand now?". Cancer Letters 324 2 (2012): 160-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS. Publicado • 10.1016/j.canlet.2012.05.023 Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V.. "Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect". Oncology Reports 28 3 (2012): 1057-1062. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS. Publicado • 10.3892/or.2012.1904 Duarte, S.; Faneca, H.; Lima, M.C.P.D.. "Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo". International Journal of Pharmaceutics 423 2 (2012): 365-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS. Publicado • 10.1016/j.ijpharm.2011.12.035 Duarte, S.; Faneca, H.; Pedroso De Lima, M.C.. "Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum". Journal of Controlled Release 149 3 (2011): 264-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS. Publicado • 10.1016/j.jconrel.2010.10.032 Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana Luísa; Duarte, Sónia; Henriques, Ana; Paiva, Artur; et al. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA". The Journal of Gene Medicine 10 11 (2008): 1210-1222. http://dx.doi.org/10.1002/jgm.1247. Publicado • 10.1002/jgm.1247 Duarte, S.P.; Fortes, A.G.; Prazeres, D.M.F.; Marcos, J.C.. "Preparation of plasmid DNA polyplexes from alkaline lysates by a two-step aqueous two-phase extraction process". Journal of Chromatography A 1164 1-2 (2007): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548030710&partnerID=MN8TOARS. Publicado • 10.1016/j.chroma.2007.06.061
Capítulo de livro	Nóbrega, Clévio; Simões, Ana Teresa; Duarte-Neves, Joana; Duarte, Sónia; Vasconcelos-Ferreira, Ana; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". In Polyglutamine Disorders in Advances in Experimental Medicine and Biology, 349-367. Springer International Publishing, 2018. Publicado • 10.1007/978-3-319-71779-1_18 Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; Costa, Pedro M; Pereira de Almeida, Luis; Pedroso De Lima, M.C.. "Gene silencing as a promising strategy to target CNS and neurological disorders". In Gene Silencing: Theory, Techniques and Applications, 81-110. Nova Science Publishers, 2013. Publicado Faneca, Henrique; Cardoso, Ana Luísa; Trabulo, Sara; Duarte, Sónia; de Lima, Maria C. Pedroso. "Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications". In Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 153-184. Springer Netherlands, 2013. 10.1007/978-94-007-6010-3_6
Poster em conferência	A C Silva, C Henriques, D D Lobo, A R Fernandes, M Lopes, D Pereira,; S P Duarte, R Baganha, S M Lopes, M Santana, R J Nobre L Pereira de Almeida. "Allele-specific silencing of mutant ATXN3 rescues motordeficits and neuropathology in a severely impaired mouse model of spinocerebellar ataxia type 3 (SCA3) upon intra-cisterna magna administration". Trabalho apresentado em 30th ESGCT meeting, 24th-27th October 2023, 2023. Silva, Patrick; Santana, Magda M; Pinto, Maria; Gaspar, Laetitia S; Nobre, Rui Jorge; Duarte, Sónia; Monteiro Marques, Tania; et al. "Discrimitating spinocerebellar ataxia type 3 ataxic mutation carriers from control and pre-ataxic throuh miRNA expression profiles in plasma-derived extracellular vesicles". Trabalho apresentado em EMBO|EMBL Symposium: The non-coding genome, 2023. Silva, Ana Carolina; Henriques, Carina; Lobo, Diana Duarte; Pereira, Dina; Duarte, Sónia; Lopes, Sara Monteiro; Lopes, Miguel Monteiro; et al. "Investigating routes of administration and AAV serotypes for development of a gene-based therapy for spinocerebellar ataxia type 3 (SCA3)". Trabalho apresentado em ESGCT 30th Congress, 2023. Santos, Bárbara; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel,; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P., et al.. "GreenLabsCIBB - One path for sustainable research". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Mendes, Cândida; Marques, Carla; Mota, Sandra I.; Afonso, Mariana; Alves, André; Amaral, Sandra; Candeias, Emanuel; Cardoso, Maria; Cortes, Luísa; Cruz, Teresa; Da Silva, Jéssica; Duarte, Sónia P. et al.. ""Collection Points"-Reuse and Recycling". Trabalho apresentado em Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Alarico, S., Afonso M., Alves A., Amaral S., Amorim R., Candeias E., Cardoso M., Cortes L., Cruz T., Duarte S.P., Faria ; Gonçalves M., Lavoura N., Léger H., Manadas B., Marques C., Marques C.I., Mele M., Mendes C., Miranda C., Mota S.I., Rib; Romera L., Roxo I. , Santos B., Santiago A.R., Santos D., Sebastião A.I., Simões I.. "GreenLabsCiBB | One path for sustainable research". Trabalho apresentado em Envisioning the research centres of the future | EU-LIFE, June 2023, Gulbenkian, 2023. Carina Henriques, Miguel Lopes, Patricia Albuquerque, David Rufino-Ramos, Laetitia Gaspar, Diana Lobo, Ana Carolina Silv; Sónia Duarte, Casey A. Maguire, Magda Santana, Luis Pereira de Almeida*, Rui Jorge Nobre*. "ISOLATION OF NATURAL AND BIOLOGICALLY ACTIVE EV-AAVs FOR BRAIN GENE DELIVERY". Trabalho apresentado em American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting, May 16-20, 2023 | Los Angeles, CA, 2023. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Trabalho apresentado em FENS Regional Meeting 2023 (FRM), 2023. Serra, Beatriz; Duarte, Sónia; Françoise, PIGUET; Nathalie Cartier; Alves, Sandro; de Almeida, Luis Pereira; Perfeito, Rita. "Validation of the brain-targeting AAV- PHP.eB encoding cholesterol hydroxylase CYP46A1: a promising non-invasive therapeutic strategy for Spinocerebellar Ataxia Type 3". Trabalho apresentado em FENS Regional Meeting 2023, 2023. Beatriz Guedes, Sónia Duarte, Sandra Morais Cardoso, Ana Raquel Esteves. "Unmasking miRNA 486-5p role in Parkinson's disease: inflammation in the spotlight". Trabalho apresentado em AD/PD 2023 International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders. 28 March-1 April, Gothenburg, Sweden., 2023. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022. D Santos, MI Santos, R Baganha, RJ Nobre, M Figiel, ; L Pereira de Almeida, ; and SP Duarte. Autor correspondente: and SP Duarte. "P231 MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. C Henriques, M Lopes, P Albuquerque, D Rufino-Ramos, L Gaspar, D Lobo, A C Silva, ; R Baganha, S Duarte, C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte,; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, 2022. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre; Maciej Figiel, Luís Pereira de Almeida; Sónia Patrícia Duarte (Presenter). Autor correspondente: Sónia Patrícia Duarte (Presenter). "Investigating microRNA dysregulation towards the development of a microRNA-based therapy for Spinocerebellar ataxia type-3|Machado-Joseph disease (SCA3|MJD)". Trabalho apresentado em CONGRESSO SPDMOV (Sociedade Portuguesa das Doenças do Movimento) 2022, April 1, 2, 2022. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Autor correspondente: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022. Maria Inês Barros, António da Silva, Inês Martins, Sónia Duarte, Rui Jorge Nobre, Ana Teresa Simões, ; Luís Pereira de Almeida* and Catarina Oliveira Miranda*. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Sandra O. Braz, Catarina Vinhas, Daniel Henriques, Ricardo Moreira, Rosário Faro, Sónia Duarte, ; Luis Pereira de Almeida and Liliana S. Mendonça. "Cerebellar transplantation of iPSC-derived neuroepithelial stem cells silenced for mutant ATXN3 for Machado-Joseph disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Diana Santos, Maria Inês Santos, Rafael Baganha, Rui Jorge Nobre, Luis Pereira de Almeida* ; Sónia P. Duarte*. Autor correspondente: Sónia P. Duarte*. "Restoration of dysregulated microRNA levels in a transgenic mouse model of Machado-Joseph disease as a novel therapeutic approach". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Maria Inês Santos, Ana Daniela Oliveira, Maria M. Pinto, Magda M. Santana, Diana Santos, Ana Rita Álvaro,; Luís Pereira de Almeida* ; Sónia P. Duarte*. Autor correspondente: Sónia P. Duarte*. "miRNA dysregulation in Machado-Joseph disease: what can we learn from human induced pluripotent stem cell-based models?". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Beatriz Serra; Sónia P. Duarte; Nathalie Cartier; Sandro Alves; Luís Pereira de Almeida; Rita Perfeito. "Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non- invasive therapeutic strategy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Ana Carolina Silva, Diana D. Lobo, Carina Henriques, Inês M. Martins, Sara M. Lopes, Sónia P. Duarte, Elizabeth Wagner,; Rui Jorge Nobre* and Lui´s Pereira de Almeida*; *Equal contribution. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 1 - 3 December, 2021, 2021. Silva, Ana Carolina; Lobo, Diana Duarte; Henriques, Carina; Martins, Maria Inês; Lopes, Sara Monteiro; Duarte, Sónia Patrícia; Wagner, E; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Trabalho apresentado em 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal, 2021. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, João Barata, Diana Santos,; Maciej Figiel, Albert La Spada, Luis Pereira de Almeida. "MicroRNA profiling in Spinocerebellar ataxia type-3: On the development of a miRNA-based therapy". Trabalho apresentado em NAF's biennial Ataxia Investigators Meeting (AIM 2020)---Postponed to May 24-27, 2021, virtual AIM due to COVID pandemics, 2021. Mendonça Liliana; Daniel Henriques; Vanessa Fernandes; Ricardo Moreira; Ana C. Vinhas; Rosário Faro; Sónia Duarte; et al.. ""Patient specific IPSC-derived neuroepithelial stem cells for cell-based therapy in Machado-Joseph disease"". Trabalho apresentado em FENS 2020 Virtual Forum (accepted for electronic poster presentation), July 11-15, 2020, 2020. Lodewilk Toonen, Raygene Martier, Rui Nobre, Astrid Valles, Janice Stricker-Shaver,; Jeannette Hübener-Schmid, Sonia Duarte, et al.. "Assessment of the Novel AAV-Based miQURE Gene Therapy in SCA3 Animal Models". Trabalho apresentado em ASGCT 23rd Annual meeting, 2020. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Trabalho apresentado em 3rd BEB Day (2019), 2019. Barros MI; Martins Inês; Duarte, S.P.; Nobre RJ; Simões AT; Miranda CO; Pereira de Almeida L. "Assessing the putative role of mesenchymal stromal cells effectors in Machado-Joseph disease". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019. Ricardo Moreira; Liliana S. Mendonça; Daniel Henriques; Sónia Duarte; et al.. ""Investigation of Mutant Ataxin-3 spreading in Machado-Joseph Disease"". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019, 2019. Henriques C; Lopes, M; Albuquerque PR; Rufino-Ramos D; Gaspar L; Lobo D; Duarte S; et al. "Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases". Trabalho apresentado em 5th GEIVEX Symposium, November 6-8, 2019, 2019. Carlos A. Matos; André Conceição; Frederico Pena; Sara Lopes; Duarte, Sónia; Catarina Miranda; Luis Pereira de Almeida. "TRANSCRIPTIONAL REPRESSION OF MUTANT HUMAN ATNX3 USING CRISPR INTERFERENCE MITIGATES THE PATHOLOGICAL PHENOTYPE OF AN IN VIVO MACHADO-JOSEPH DISEASE MODEL". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Liliana S. Mendonça; Ricardo Moreira; Daniel Henriques; Duarte, Sónia; Teresa Rodrigues; Henrique Girão; Jens C. Schwamborn; Luis Pereira de Almeida. "INVESTIGATION OF MUTANT ATAXIN-3 SPREADING IN MACHADO-JOSEPH DISEASE". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Duarte S; et al.. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), May 30-June 1, 2019, Lisbon, Portugal., 2019. Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Miranda, João Barata, Albert La Spada, ; Luis Pereira de Almeida. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Miranda CO; Adriana Machado; Silva Teresa P; Barata, J.; Vasconcelos-Ferreira A; Pereira, Dina; Duarte S; et al.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, December 6 - 7th, 2018, 2018. Duarte, Sónia; B Estremores, J Cunha-Santos, C O Miranda, J Barata, A R La Spada, L P de Almeida. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-joseph disease mouse models". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C; Sereno J, Peretrella L, Paiva V, Castelhano J, Nobre R, Gomes C, Castelo-Branco M and de Almeida LP. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. L Mendonça, D Henriques, R Moreira, S Duarte, JC Schwamborn and L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland., 2018. Miranda C.O., Machado A., Silva T., Barata J., Pereira D., Vasconcelos-Ferreira A., Nóbrega C., Peretrella L.; Sereno J., Castelhano J., Duarte S., Nobre R., Paiva V., Castelo-Branco M. and de Almeida L.P.. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), October 12-14, 2017, Covilhã, Portugal., 2017. Duarte, Sónia; Miranda, C.O., Cunha-Santos, J., Barata, J., Estremores, B., La Spada, A.R., de Almeida, L.P.. "Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Trabalho apresentado em International Ataxia Research Conference, September 27-30, 2017, Pisa, Italy., 2017. Miranda C.O., Machado A., Silva T., Barata J., Nóbrega C., Duarte S.; Nobre R., Sereno J., Paiva V., Castelhano J., Castelo-Branco M. and de Almeida L.P. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017. Duarte, Sónia; Catarina Oliveira Miranda, Janete Cunha-Santos, João Barata, Albert R. La Spada, Luís Pereira de Almeida. "Autophagy activation mediated by let-7 alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, May 25-26, 2017, Braga, Portugal., 2017. Duarte, Sónia; La Spada A.R., de Almeida L.P.. "Unravelling let-7 role in Machado-Joseph Disease". Trabalho apresentado em XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Trabalho apresentado em Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "A novel folate-associated lipoplex formulation for gene delivery: evaluation of the potential for HSV-tk/valganciclovir suicide gene therapy in vitro and in vivo". Trabalho apresentado em XX Porto cancer meeting, April 28-29, 2011, Porto, Portugal., 2011. Duarte, Sónia; Faneca H. and Pedroso de Lima M.C.. "Development of folate-lipid-based systems for tumor-targeted gene delivery". Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010. Duarte, Sónia; Faneca H., Trabulo S., Cardoso A.L. and Pedroso de Lima M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery". Trabalho apresentado em XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium., 2008. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Gomes P., Simões S., de Lima M.C.. "Association of S413-PV cell penetrating peptide with cationic liposomes: a synergistic effect on the intracellular delivery of plasmid DNA". Trabalho apresentado em 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland., 2008. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., Pedroso de Lima M.C. "S4(13)-PV cell penetrating peptide-based systems for the intracellular delivery of plasmid DNS and siRNA". Trabalho apresentado em V Encontro anual do CNC, December 20-21, 2007, Coimbra, Portugal., 2007. Duarte S., Marcos J.C.. "Quantification of plasmid DNA in the presence of PEGylated polyethyleneimine by hydrophobic interaction chromatography". Trabalho apresentado em 5º Encontro Nacional de Cromatografia, December 10-12, 2007, Aveiro, 2007. Trabulo S., Mano M., Faneca H., Cardoso A.L., Duarte S., Simões S., de Lima M.C.. "Enhancement of the intracellular delivery of siRNA and plasmid DNA using S4(13)-PV cell penetrating peptide-based systems". Trabalho apresentado em 2nd Intracellular Delivery of Therapeutic Molecules – From Concept to Application, September 19-21, 2007, Grenoble, France., 2007. Duarte, Sónia; Fortes A.G., Prazeres D.M.F., Marcos J.C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems". Trabalho apresentado em 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain., 2007. Duarte, Sónia; Barbosa H., Prazeres D.M.F. and Marcos J.C.. "Isolation of DNA Plasmid from Polyethyleneimine Polyplexes in Aqueous Two-Phase Systems". Trabalho apresentado em International Conference on Biopartitioning and Purification (BPP 2005), June 20-24, 2005, Netherlands., 2005.
Resumo em conferência	C Henriques, M Lopes, P Albuquerque, D Rufino?Ramos, L Gaspar, D Lobo, A C Silva, R Baganha, S Duarte; C Maguire, M Santana, L Pereira de Almeida, R J Nobre. "P087 Production and isolation of natural and biologically active exo-AAvs for brain gene delivery". Trabalho apresentado em ESGCT 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11–14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts A C Silva, D D Lobo, C Henriques, I M Martins, S M Lopes, S P Duarte; E Wagner, R J Nobre, L Pereira de Almeida. "P214 Silencing of mutant ATXN3 through antisense oligonucleotides rescues molecular and neuropathological features in Machado-Joseph disease mice". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts B Serra, S P Duarte, N Cartier, S Alves, L P de Almeida, R Perfeito. "P221 Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy". Trabalho apresentado em European Society of Gene Therapy (ESGCT), 29th Annual Congress In collaboration with BSGCT Edinburgh, UK October 11-14, Edinburgh, 2022. Publicado • http://doi.org/10.1089/hum.2022.29225.abstracts Carlos A. Matos; Frederico Pena; Andre Conceicao; Sara Lopes; Sónia Duarte; et al.. "CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model. MOLECULAR THERAPY (2019) 27 (4): 120-121". Trabalho apresentado em 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019, 2019. Publicado Catarina Oliveira Miranda; Adriana Marcelo; Teresa Pereira Silva; Joao Barata; Ana Vasconcelos-Ferreira; Dina Pereira; Sónia Duarte; et al.. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy, In European Journal of Clinical Investigation (2019) 49 (S1): 44-44". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Publicado • 10.1111/eci.13109 C Matos; F Pena; A Conceicao; Lopes S.; Duarte, S.P; et al.. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model, In European Journal of Clinical Investigation (2019) 49 (S1): 86-87". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), May 22-24, 2019, Coimbra, Portugal., 2019. Publicado • 10.1111/eci.13109 Duarte, Sónia; Beatriz Estremores; Janete Cunha-Santos; Miranda, Catarina; João Barata; AR La Spada; Pereira de Almeida, Luis. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-Joseph disease mouse models, HUMAN GENE THERAPY (2018) 29 (12), A81-A81". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts CO Miranda; A Marcelo; TP Silva; J Barata; A Vasconcelos-Ferreira; D Pereira; S Duarte; et al.. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, HUMAN GENE THERAPY (2018) 29 (12), A56-A56". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts L Mendonça; D Henriques; R Moreira; Sónia Duarte; JC Schwamborn; L Pereira de Almeida. "Generation and transplantation of patient-specific iPSC-derived neuroepithelial stem cells for Machado-Joseph disease treatment, HUMAN GENE THERAPY (2018) 29 (12), A66-A66". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), October 16-19, 2018, Lausanne, Switzerland, 2018. Publicado • 10.1089/hum.2018.29077.abstracts Duarte, S.; de Almeida LP; La Spada, A.R.. "Unravelling let-7 role in Machado-Joseph Disease, In Human Gene Therapy (2016) 27 (11), A1-A185". Trabalho apresentado em XXIVth Annual Congress of European Society of Gene and cell Therapy, October 18-21, 2016, Florence, Italy, 2016. Publicado • 10.1089/hum.2016.29035.abstracts Duarte, S.; Faneca, H.; Pedroso de Lima, M.C.. "Development of folate-lipid-based systems for tumour-targeted gene delivery, In Ejc Supplements (2010) 8 (5): 72-72". Trabalho apresentado em 21st Meeting of the European Association for Cancer Research, June 26-29, 2010, Oslo, Norway., 2010. Publicado • 10.1016/s1359-6349(10)71079-x Trabulo, S.; Mano, M; Faneca, H.; Cardoso, A.L.; Duarte, S.; Gomes, P.; Simões, S.; Pedroso De Lima, M.C.. "Association of S4 (13)-PV cell penetrating peptide with cationic liposomes: A synergistic effect on the intracellular delivery of plasmid DNA, In Journal of Peptide Science (2008) 14 (8), 135-135". Trabalho apresentado em 30th European Peptide Symposium (30EPS), August 31-September 5, 2008, Helsinki, Finland, 2008. Publicado • 10.1002/psc.1090 Duarte, S.; Faneca, H.; Trabulo, S.; Cardoso, A.L.; Pedroso de Lima, M.C.. "Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery, Human Gene Therapy (2008) 19 (10): 1153". Trabalho apresentado em XVIth European Society of Gene and Cell Therapy Meeting, November 12-16, 2008, Bruges, Belgium, 2008. Publicado • 10.1089/hum.2008.1034 Duarte, Sónia; Fortes, António G.; Prazeres, Duarte. M.; Marcos, João C.. "Integration of plasmid DNA purification and molecular therapy agent preparation using aqueous two-phase systems, In Journal of Biotechnology (2007) 131 (2): S6". Trabalho apresentado em 13th European Congress on Biotechnology, September 16-19, 2007, Barcelona, Spain, 2007. Publicado • 10.1016/j.jbiotec.2007.07.012
Tese / Dissertação	Duarte, Sónia. "ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2012. http://hdl.handle.net/10316/20480. Duarte, Sónia. "Validação de uma técnica de HPLC para determinação de anti-inflamatórios do grupo do Etofenamato". Licenciatura, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2004.

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MicroRNA profiling in human cell-based models of Machado-Joseph disease. 2020. Maria Inês Santos, Sónia Patrícia Duarte. http://hdl.handle.net/10316/92999. The role of autophagy activation-mediated by Let-7 in a transgenic mouse model of Machado-Joseph Disease. 2018. Estremores, Beatriz; Duarte, Sónia Patricia. http://hdl.handle.net/10316/86233.