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Teresa M. Ribeiro-Rodrigues is a researcher at the Coimbra Institute for Clinical and Biomedical Research (iCBR) and a Fluorescence Microscopy specialist at the Microscopy and Bioimaging Lab (iLAB, FMUC). She obtained her PhD in 2024 from the Inter-University Doctoral Programme in Ageing and Chronic Diseases, conducting research at the University of Coimbra, Newcastle University, University of Liverpool, and Harvard Medical School. Her research focuses on endothelial cell biology, intercellular communication, and proteostasis, with a particular emphasis on cardiovascular diseases. Her contributions to cardiovascular and cellular biology have resulted in high-impact publications in journals such as Journal of Cell Science, Cardiovascular Research, EMBO J, Autophagy, FASEB Journal, PLoS Computational Biology, Trends in Cell Biology, and Scientific Reports. Teresa has presented her work at numerous international conferences (including International Gap Junction Conference 2022 - Emerging Star Award and ESC Congress 2013 - Young Investigators Award(Basic Science)) and has been awarded multiple research grants, including a FLAD research grant, which enabled her to train at Harvard Medical School in advanced microscopy and intercellular trafficking. Beyond research, Teresa has actively contributed to the supervision of master’s students (3 finished, 1 ongoing), participation in teaching activities for master’s and PhD courses, and the organization of international conferences, including SINAL 2024, the 9th EU-CARDIOPROTECTION COST Action Meeting, and the 1st Meeting on Vesicular Biology (MVB). She is an active reviewer for journals such as Journal of Cellular and Molecular Medicine, International Journal of Molecular Sciences, and Revista Portuguesa de Cardiologia. At iLAB, Teresa provides training and technical support in advanced imaging techniques, overseeing experiment design, sample preparation, and data analysis. She plays a key role in implementing and optimizing novel microscopy methodologies, ensuring the facility’s continued innovation and excellence. She has participated in several specialized training programs, including courses on advanced imaging techniques and image analysis.
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Identificação

Identificação pessoal

Nome completo
Teresa Margarida Ribeiro-Rodrigues

Nomes de citação

  • Ribeiro-Rodrigues, Teresa M

Identificadores de autor

Ciência ID
D418-8C9D-E0BC
ORCID iD
0000-0002-5169-6090
Researcher Id
A-1585-2018
Formação
Grau Classificação
2014 - 2024
Concluído
 Ageing and Chronic Diseases (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Minho Escola de Medicina, Portugal
"The role of protein quality control and intercellular communication in cardiovascular diseases" (TESE/DISSERTAÇÃO)
2013
Concluído
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"“Quantitative characterization of vascular formations in vitro and in vivo”" (TESE/DISSERTAÇÃO)
 19 valores
2011
Concluído
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/03 - 2024/03 Assistente de Investigação (carreira) (Investigação) Instituto do Ambiente Tecnologia e Vida, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02 - 2019/06 Investigador visitante (Investigação) Harvard Medical School, Estados Unidos
2011 - 2013 Estagiário de Investigação (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/04 - 2021 Research Fellow - Project PPBI - Portuguese Platform of BioImaging Universidade de Coimbra Faculdade de Medicina, Portugal
2016/01 - 2016/03 Visiting Student Newcastle University Institute for Cell and Molecular Biosciences, Reino Unido
2015/02 - 2015/04 Visiting Student University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido
Projetos

Bolsa

Designação Financiadores
2018/04 - Atual Portuguese Platform of BioImaging
PINFRA/22122/2016
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Em curso
2011/09 - 2013/12/31 Angiogenesis in Diabetic Retinopathy: Integrating Experiments and Modelling
PTDC/SAU-ENB/110354/2009
Bolseiro de Técnico de Investigação
Universidade de Coimbra Centro de Física Computacional, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2025 - Atual Nano-to-Heart
GA N° 101095426
Investigador
2022/01/01 - 2023/12/31 ConCOEUR: Unveiling the impact of Connexin43 (Cx43)-mediated gene expression at the crossroads of aortic valve stenosis and left ventricle hypertrophy
EXPL/MED-OUT/0590/2021
10.54499/EXPL/MED-OUT/0590/2021
Investigador
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/26 - 2021/07/25 On the right side: unveiling the mechanisms of pulmonary hypertension reversability and the heart failure progression
PTDC/MEC-CAR/32414/2017
Investigador
Universidade de Coimbra, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/22 - 2021/06/21 A novel mechanism to re-pair Heart Failure with preserved Ejection Fraction (HFpEF) and endothelial damage
PTDC/MED-PAT/32179/2017
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Sara F.F. Almeida; Alexandra Fonseca; José Sereno; Hugo R. S. Ferreira; Mariana Lapo-Pais; Tânia Martins-Marques; Teresa M Ribeiro-Rodrigues; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small (2022): 2203999-2203999. http://dx.doi.org/10.1002/smll.202203999.
    10.1002/smll.202203999
  2. Amorim M; Martins B; Caramelo F; Gonçalves C; Trindade G; Simão J; Barreto P; et al. "Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/35692536.
    10.3389/fmed.2022.873483
  3. Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules (2021): https://doi.org/10.3390/biom11060770.
    10.3390/biom11060770
  4. Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.". Autophagy (2021): http://europepmc.org/abstract/med/33634751.
    10.1080/15548627.2020.1797280
  5. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; de Jager, Saskia C; Zuzarte, Monica; Ferreira, Cátia; Cruz, Pedro; Reis, Liliana; et al. "Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes". Life Science Alliance 3 12 (2020): e202000821. http://dx.doi.org/10.26508/lsa.202000821.
    10.26508/lsa.202000821
  6. Gaspar LS; Santana MM; Henriques C; Pinto MM; Ribeiro-Rodrigues TM; Girão H; Nobre RJ; Pereira de Almeida L. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.". Molecular therapy. Methods & clinical development (2020): http://europepmc.org/abstract/med/32913880.
    10.1016/j.omtm.2020.07.012
  7. Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245.
    10.1002/glia.23880
  8. Pereira, Patricia M. R.; Parada, Belmiro; Ribeiro-Rodrigues, Teresa M.; Fontes-Ribeiro, Carlos A.; Girão, Henrique; Tome, Joao P. C.; Fernandes, Rosa. "Caveolin-1 modulation increases efficacy of a galacto-conjugated phthalocyanine in bladder cancer cells resistant to photodynamic therapy". Molecular Pharmaceutics (2020): http://dx.doi.org/10.1021/acs.molpharmaceut.0c00298.
    Aceite para publicação • 10.1021/acs.molpharmaceut.0c00298
  9. Catarino, Steve; Ribeiro-Rodrigues, Teresa M; Sá Ferreira, Rita; Ramalho, José; Abert, Christine; Martens, Sascha; Girão, Henrique. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells 9 4 (2020): 902. http://dx.doi.org/10.3390/cells9040902.
    10.3390/cells9040902
  10. Batista-Almeida, Daniela; Ribeiro-Rodrigues, Teresa; Martins-Marques, Tânia; Cortes, Luisa; Antunes, Manuel J.; Antunes, Pedro E.; Gonçalves, Lino; et al. "Ischaemia impacts TNT-mediated communication between cardiac cells". Current Research in Cell Biology 1 (2020): 100001. http://dx.doi.org/10.1016/j.crcbio.2020.04.001.
    10.1016/j.crcbio.2020.04.001
  11. Ferreira, Joao Vasco; Rosa Soares, Ana; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, Paulo. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790. http://dx.doi.org/10.1371/journal.pone.0223790.
    10.1371/journal.pone.0223790
  12. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Batista-Almeida, Daniela; Aasen, Trond; Kwak, Brenda R.; Girao, Henrique. "Biological Functions of Connexin43 Beyond Intercellular Communication". Trends in Cell Biology 29 10 (2019): 835-847. http://dx.doi.org/10.1016/j.tcb.2019.07.001.
    10.1016/j.tcb.2019.07.001
  13. Almeida Paiva R; Martins-Marques T; Jesus K; Ribeiro-Rodrigues T; Zuzarte M; Silva A; Reis L; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation.". Journal of cellular and molecular medicine (2018): http://europepmc.org/abstract/med/30516028.
    10.1111/jcmm.14014
  14. Delgado-Silva J; Fernandes R; Pita IR; Pereira FC; Jaguszewski M; Gutiérrez-Chico JL; Ribeiro-Rodrigues T; et al. "Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery.". Hypertension research : official journal of the Japanese Society of Hypertension (2018): http://europepmc.org/abstract/med/30006641.
    10.1038/s41440-018-0072-y
  15. Ribeiro-Rodrigues, Teresa M.; Martins-Marques, Tânia; Morel, Sandrine; Kwak, Brenda R.; Girão, Henrique. "Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes". Journal of Cell Science 130 21 (2017): 3619-3630. http://dx.doi.org/10.1242/jcs.200667.
    10.1242/jcs.200667
  16. Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
    10.1093/cvr/cvx118
  17. Melo, Tânia; Domingues, Pedro; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Segundo, Marcela A.; Domingues, M. Rosário M.. "Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach". Free Radical Biology and Medicine 106 (2017): 219-227. http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.033.
    10.1016/j.freeradbiomed.2017.02.033
  18. Da Silva-Ferrada, Elisa; Ribeiro-Rodrigues, Teresa M.; Rodríguez, Manuel S.; Girão, Henrique. "Proteostasis and SUMO in the heart". The International Journal of Biochemistry & Cell Biology 79 (2016): 443-450. http://dx.doi.org/10.1016/j.biocel.2016.09.015.
    10.1016/j.biocel.2016.09.015
  19. Sousa, Bebiana; Melo, Tânia; Campos, Ana; Moreira, Ana S.P.; Maciel, Elisabete; Domingues, Pedro; Carvalho, Rita Pereira; et al. "Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia". Journal of Cellular Physiology 231 10 (2016): 2266-2274. http://dx.doi.org/10.1002/jcp.25344.
    10.1002/jcp.25344
  20. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
    10.1038/srep13243
  21. Santos-Oliveira, Patrícia; Correia, António; Rodrigues, Tiago; Ribeiro-Rodrigues, Teresa M; Matafome, Paulo; Rodríguez-Manzaneque, Juan Carlos; Seiça, Raquel; Girão, Henrique; Travasso, Rui D. M.. "The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis". PLOS Computational Biology 11 8 (2015): e1004436. http://dx.doi.org/10.1371/journal.pcbi.1004436.
    10.1371/journal.pcbi.1004436
  22. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
    10.1042/bst20150036
  23. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
    10.1016/j.biochi.2015.02.020
  24. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
    10.1089/dna.2014.2765
  25. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
    10.1096/fj.13-248963
Capítulo de livro
  1. Teresa M Ribeiro-Rodrigues; George Kelly; Viktor I. Korolchuk; Henrique Girao. "Intercellular communication and aging". 257-274. Elsevier, 2023.
    10.1016/b978-0-12-823761-8.00005-7
  2. Batista-Almeida, Daniela; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Girao, Henrique. "The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication". In Advances in Experimental Medicine and Biology, 279-302. Springer International Publishing, 2020.
    Publicado • 10.1007/978-3-030-38266-7_12
  3. Martins-Marques, Tania; Anjo, Sandra I.; Ribeiro-Rodrigues, Teresa; Manadas, Bruno; Girao, Henrique. "Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein". In Methods in Molecular Biology, 151-172. Springer New York, 2017.
    10.1007/978-1-4939-7057-5_12
  4. Quinas-Guerra, M. M.; Ribeiro-Rodrigues, T. M.; Rodríguez-Manzaneque, Juan Carlos; Travasso, Rui D. M.. "Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach". In Systems Biology in Cancer Research and Drug Discovery, 197-227. Springer Netherlands, 2012.
    Publicado • 10.1007/978-94-007-4819-4_8
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - 2024 Unravelling the effects of Osteosarcoma-derived secretome in cardiac endothelial cell dysfunction
Orientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2018 Stents, statins and sirolimus: a new approach to prevent restenosis
Coorientador
 Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015 Exosomes release by cardiomyocytes modulate angiogenic response in heart ischemia
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
Distinções

Prémio

2022 Emerging Star Award
International Gap Junction Conference , Espanha
2019 Research Internship Grant_FLAD
Fundação Luso-Americana, Portugal
2013 Young Investigators Award - Basic Science
Société Européenne de Cardiologie, França
2012 Merit Scholarship
Universidade de Coimbra Faculdade de Medicina, Portugal

Outra distinção

2016 Short-Term Scientific Mission Grant
European Cooperation in Science and Technology, Bélgica
2015 Short-Term Scientific Mission Grant
European Cooperation in Science and Technology, Bélgica
2014 Boehringer Ingelheim Fonds Travel Grant
Boehringer Ingelheim International GmbH, Alemanha

European Molecular Biology Laboratory, Alemanha
2014 Travel Grant
tebu-bio SAS, França