Teresa Margarida Ribeiro-Rodrigues (D418-8C9D-E0BC)

Curriculum Vitae

Teresa Margarida Ribeiro-Rodrigues

Teresa M. Ribeiro-Rodrigues is a researcher at the Coimbra Institute for Clinical and Biomedical Research (iCBR) and a Fluorescence Microscopy specialist at the Microscopy and Bioimaging Lab (iLAB, FMUC). She obtained her PhD in 2024 from the Inter-University Doctoral Programme in Ageing and Chronic Diseases, conducting research at the University of Coimbra, Newcastle University, University of Liverpool, and Harvard Medical School. Her research focuses on endothelial cell biology, intercellular communication, and proteostasis, with a particular emphasis on cardiovascular diseases. Her contributions to cardiovascular and cellular biology have resulted in high-impact publications in journals such as Journal of Cell Science, Cardiovascular Research, EMBO J, Autophagy, FASEB Journal, PLoS Computational Biology, Trends in Cell Biology, and Scientific Reports. Teresa has presented her work at numerous international conferences (including International Gap Junction Conference 2022 - Emerging Star Award and ESC Congress 2013 - Young Investigators Award(Basic Science)) and has been awarded multiple research grants, including a FLAD research grant, which enabled her to train at Harvard Medical School in advanced microscopy and intercellular trafficking. Beyond research, Teresa has actively contributed to the supervision of master’s students (3 finished, 1 ongoing), participation in teaching activities for master’s and PhD courses, and the organization of international conferences, including SINAL 2024, the 9th EU-CARDIOPROTECTION COST Action Meeting, and the 1st Meeting on Vesicular Biology (MVB). She is an active reviewer for journals such as Journal of Cellular and Molecular Medicine, International Journal of Molecular Sciences, and Revista Portuguesa de Cardiologia. At iLAB, Teresa provides training and technical support in advanced imaging techniques, overseeing experiment design, sample preparation, and data analysis. She plays a key role in implementing and optimizing novel microscopy methodologies, ensuring the facility’s continued innovation and excellence. She has participated in several specialized training programs, including courses on advanced imaging techniques and image analysis.

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Identification

Personal identification

Full name: Teresa Margarida Ribeiro-Rodrigues

Citation names

Ribeiro-Rodrigues, Teresa M

Author identifiers

Ciência ID: D418-8C9D-E0BC
ORCID iD: 0000-0002-5169-6090
Researcher Id: A-1585-2018

Education

	Degree	Classification
2014 - 2024 Concluded	Ageing and Chronic Diseases (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade do Minho Escola de Medicina, Portugal "The role of protein quality control and intercellular communication in cardiovascular diseases" (THESIS/DISSERTATION)
2013 Concluded	Investigação Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal "“Quantitative characterization of vascular formations in vitro and in vivo”" (THESIS/DISSERTATION)	19 valores
2011 Concluded	Anatomia Patológica, Citológica e Tanatológica (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Affiliation

Science

	Category Host institution	Employer
2021/03 - 2024/03	Research Assistant (Research)	Instituto do Ambiente Tecnologia e Vida, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02 - 2019/06	Visiting Researcher (Research)	Harvard Medical School, United States

2011 - 2013	Research Trainee (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal

Others

	Category Host institution	Employer
2018/04 - 2021	Research Fellow - Project PPBI - Portuguese Platform of BioImaging	Universidade de Coimbra Faculdade de Medicina, Portugal

2016/01 - 2016/03	Visiting Student	Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom

2015/02 - 2015/04	Visiting Student	University of Liverpool Department of Cellular and Molecular Physiology, United Kingdom

Projects

Grant

	Designation	Funders
2018/04 - Current	Portuguese Platform of BioImaging PINFRA/22122/2016 Research Fellow	Fundação para a Ciência e a Tecnologia Ongoing
2011/09 - 2013/12/31	Angiogenesis in Diabetic Retinopathy: Integrating Experiments and Modelling PTDC/SAU-ENB/110354/2009 Research Technician Fellow Universidade de Coimbra Centro de Física Computacional, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2025 - Current	Nano-to-Heart GA N° 101095426 Researcher
2022/01/01 - 2023/12/31	ConCOEUR: Unveiling the impact of Connexin43 (Cx43)-mediated gene expression at the crossroads of aortic valve stenosis and left ventricle hypertrophy EXPL/MED-OUT/0590/2021 10.54499/EXPL/MED-OUT/0590/2021 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2021/07/25	On the right side: unveiling the mechanisms of pulmonary hypertension reversability and the heart failure progression PTDC/MEC-CAR/32414/2017 Researcher Universidade de Coimbra, Portugal Centro Hospitalar e Universitário de Coimbra EPE, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/22 - 2021/06/21	A novel mechanism to re-pair Heart Failure with preserved Ejection Fraction (HFpEF) and endothelial damage PTDC/MED-PAT/32179/2017 Researcher Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter

Teresa M Ribeiro-Rodrigues; George Kelly; Viktor I. Korolchuk; Henrique Girao. "Intercellular communication and aging". 257-274. Elsevier, 2023.
10.1016/b978-0-12-823761-8.00005-7
Batista-Almeida, Daniela; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Girao, Henrique. "The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication". In Advances in Experimental Medicine and Biology, 279-302. Springer International Publishing, 2020.
Published • 10.1007/978-3-030-38266-7_12
Martins-Marques, Tania; Anjo, Sandra I.; Ribeiro-Rodrigues, Teresa; Manadas, Bruno; Girao, Henrique. "Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein". In Methods in Molecular Biology, 151-172. Springer New York, 2017.
10.1007/978-1-4939-7057-5_12
Quinas-Guerra, M. M.; Ribeiro-Rodrigues, T. M.; Rodríguez-Manzaneque, Juan Carlos; Travasso, Rui D. M.. "Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach". In Systems Biology in Cancer Research and Drug Discovery, 197-227. Springer Netherlands, 2012.
Published • 10.1007/978-94-007-4819-4_8

Journal article

Sara F.F. Almeida; Alexandra Fonseca; José Sereno; Hugo R. S. Ferreira; Mariana Lapo-Pais; Tânia Martins-Marques; Teresa M Ribeiro-Rodrigues; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small (2022): 2203999-2203999. http://dx.doi.org/10.1002/smll.202203999.
10.1002/smll.202203999
Amorim M; Martins B; Caramelo F; Gonçalves C; Trindade G; Simão J; Barreto P; et al. "Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/35692536.
10.3389/fmed.2022.873483
Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules (2021): https://doi.org/10.3390/biom11060770.
10.3390/biom11060770
Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.". Autophagy (2021): http://europepmc.org/abstract/med/33634751.
10.1080/15548627.2020.1797280
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; de Jager, Saskia C; Zuzarte, Monica; Ferreira, Cátia; Cruz, Pedro; Reis, Liliana; et al. "Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes". Life Science Alliance 3 12 (2020): e202000821. http://dx.doi.org/10.26508/lsa.202000821.
10.26508/lsa.202000821
Gaspar LS; Santana MM; Henriques C; Pinto MM; Ribeiro-Rodrigues TM; Girão H; Nobre RJ; Pereira de Almeida L. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.". Molecular therapy. Methods & clinical development (2020): http://europepmc.org/abstract/med/32913880.
10.1016/j.omtm.2020.07.012
Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245.
10.1002/glia.23880
Pereira, Patricia M. R.; Parada, Belmiro; Ribeiro-Rodrigues, Teresa M.; Fontes-Ribeiro, Carlos A.; Girão, Henrique; Tome, Joao P. C.; Fernandes, Rosa. "Caveolin-1 modulation increases efficacy of a galacto-conjugated phthalocyanine in bladder cancer cells resistant to photodynamic therapy". Molecular Pharmaceutics (2020): http://dx.doi.org/10.1021/acs.molpharmaceut.0c00298.
Accepted • 10.1021/acs.molpharmaceut.0c00298
Catarino, Steve; Ribeiro-Rodrigues, Teresa M; Sá Ferreira, Rita; Ramalho, José; Abert, Christine; Martens, Sascha; Girão, Henrique. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells 9 4 (2020): 902. http://dx.doi.org/10.3390/cells9040902.
10.3390/cells9040902
Batista-Almeida, Daniela; Ribeiro-Rodrigues, Teresa; Martins-Marques, Tânia; Cortes, Luisa; Antunes, Manuel J.; Antunes, Pedro E.; Gonçalves, Lino; et al. "Ischaemia impacts TNT-mediated communication between cardiac cells". Current Research in Cell Biology 1 (2020): 100001. http://dx.doi.org/10.1016/j.crcbio.2020.04.001.
10.1016/j.crcbio.2020.04.001
Ferreira, Joao Vasco; Rosa Soares, Ana; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, Paulo. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790. http://dx.doi.org/10.1371/journal.pone.0223790.
10.1371/journal.pone.0223790
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Batista-Almeida, Daniela; Aasen, Trond; Kwak, Brenda R.; Girao, Henrique. "Biological Functions of Connexin43 Beyond Intercellular Communication". Trends in Cell Biology 29 10 (2019): 835-847. http://dx.doi.org/10.1016/j.tcb.2019.07.001.
10.1016/j.tcb.2019.07.001
Almeida Paiva R; Martins-Marques T; Jesus K; Ribeiro-Rodrigues T; Zuzarte M; Silva A; Reis L; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation.". Journal of cellular and molecular medicine (2018): http://europepmc.org/abstract/med/30516028.
10.1111/jcmm.14014
Delgado-Silva J; Fernandes R; Pita IR; Pereira FC; Jaguszewski M; Gutiérrez-Chico JL; Ribeiro-Rodrigues T; et al. "Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery.". Hypertension research : official journal of the Japanese Society of Hypertension (2018): http://europepmc.org/abstract/med/30006641.
10.1038/s41440-018-0072-y
Ribeiro-Rodrigues, Teresa M.; Martins-Marques, Tânia; Morel, Sandrine; Kwak, Brenda R.; Girão, Henrique. "Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes". Journal of Cell Science 130 21 (2017): 3619-3630. http://dx.doi.org/10.1242/jcs.200667.
10.1242/jcs.200667
Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
10.1093/cvr/cvx118
Melo, Tânia; Domingues, Pedro; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Segundo, Marcela A.; Domingues, M. Rosário M.. "Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach". Free Radical Biology and Medicine 106 (2017): 219-227. http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.033.
10.1016/j.freeradbiomed.2017.02.033
Da Silva-Ferrada, Elisa; Ribeiro-Rodrigues, Teresa M.; Rodríguez, Manuel S.; Girão, Henrique. "Proteostasis and SUMO in the heart". The International Journal of Biochemistry & Cell Biology 79 (2016): 443-450. http://dx.doi.org/10.1016/j.biocel.2016.09.015.
10.1016/j.biocel.2016.09.015
Sousa, Bebiana; Melo, Tânia; Campos, Ana; Moreira, Ana S.P.; Maciel, Elisabete; Domingues, Pedro; Carvalho, Rita Pereira; et al. "Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia". Journal of Cellular Physiology 231 10 (2016): 2266-2274. http://dx.doi.org/10.1002/jcp.25344.
10.1002/jcp.25344
Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
10.1038/srep13243
Santos-Oliveira, Patrícia; Correia, António; Rodrigues, Tiago; Ribeiro-Rodrigues, Teresa M; Matafome, Paulo; Rodríguez-Manzaneque, Juan Carlos; Seiça, Raquel; Girão, Henrique; Travasso, Rui D. M.. "The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis". PLOS Computational Biology 11 8 (2015): e1004436. http://dx.doi.org/10.1371/journal.pcbi.1004436.
10.1371/journal.pcbi.1004436
Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
10.1042/bst20150036
Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
10.1016/j.biochi.2015.02.020
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
10.1089/dna.2014.2765
Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
10.1096/fj.13-248963

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024 - 2024	Unravelling the effects of Osteosarcoma-derived secretome in cardiac endothelial cell dysfunction Supervisor	Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2018	Stents, statins and sirolimus: a new approach to prevent restenosis Co-supervisor	Medicina (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015	Exosomes release by cardiomyocytes modulate angiogenic response in heart ischemia Co-supervisor	Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal

Distinctions

Award

2022	Emerging Star Award International Gap Junction Conference , Spain
2019	Research Internship Grant_FLAD Fundação Luso-Americana, Portugal
2013	Young Investigators Award - Basic Science Société Européenne de Cardiologie, France
2012	Merit Scholarship Universidade de Coimbra Faculdade de Medicina, Portugal

Other distinction

2016	Short-Term Scientific Mission Grant European Cooperation in Science and Technology, Belgium
2015	Short-Term Scientific Mission Grant European Cooperation in Science and Technology, Belgium
2014	Boehringer Ingelheim Fonds Travel Grant Boehringer Ingelheim International GmbH, Germany European Molecular Biology Laboratory, Germany
2014	Travel Grant tebu-bio SAS, France