Teresa Margarida Ribeiro Rodrigues (D418-8C9D-E0BC)

Curriculum Vitae

Teresa Margarida Ribeiro Rodrigues

Teresa M. Ribeiro-Rodrigues is a PhD candidate and the light microscopy manager in the Microscopy unit at Faculty of Medicine, University of Coimbra. As part of her training, Teresa participated in several courses including: Fundamentals of Widefield and Confocal Microscopy, IMARIS training course for Facility staff, Introduction to data analysis and image processing with MATLAB, Advanced Imaging Methods in Neuroscience, Microscopy data analysis and Advanced fluorescence imaging techniques. Of note, after being awarded with a research grant by FLAD (Fundação Luso-Americana), Teresa spend half year in one of the world's top laboratory in the area of microscopy and intercellular trafficking, the Kirchhausen Lab, at Harvard Medical School, where she had the opportunity to gather theoretical and technical knowledge about state of the art microscopy techniques. Her research focuses on ubiquitin dependent proteostasis and intercellular communication and has resulted in publications in reputable scientific journals, such as the Journal of Cell Science, Cardiovascular Research, FASEB Journal, PLoS Computational Biology, Trends inCell Biology and Scientific Reports. Moreover, Teresa participated, with presentation of her work, in many international congresses including the International Gap Junction Conference and ESC Congress. She is recipient of several grants which allowed her to spend various periods in external labs to deepen her scientific knowledge and technical skills, in reference groups in the area deubiquitinating enzymes and autophagy. In addition to the scientific part, Teresa actively participated in the organization of international congresses and the Electron Microscopy Technical Meeting, held in Coimbra, as well as in the training of Master's students, not only in the monitoring of practical laboratory work, but also in theoretical classes and importantly, as a scientific supervisor of 2 master's students. She has also served as reviewer for several journals such as Sci Rep, MedComm, JCellMolMed., Cells, IJMS, Immuno and Revista Portuguesa de Cardiologia.

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Identification

Personal identification

Full name: Teresa Margarida Ribeiro Rodrigues

Citation names

Ribeiro-Rodrigues, Teresa M

Author identifiers

Ciência ID: D418-8C9D-E0BC
ORCID iD: 0000-0002-5169-6090
Researcher Id: A-1585-2018

Education

	Degree	Classification
2014 - 2020 Ongoing	Envelhecimento e Doenças Crónicas (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade do Minho Escola de Medicina, Portugal
2013 Concluded	Investigação Biomédica (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal "“Quantitative characterization of vascular formations in vitro and in vivo”" (THESIS/DISSERTATION)	19 valores
2011 Concluded	Anatomia Patológica, Citológica e Tanatológica (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Affiliation

Science

	Category Host institution	Employer
2021/03 - Current	Research Assistant (Research)	Instituto do Ambiente Tecnologia e Vida, Portugal
	Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02 - 2019/06	Visiting Researcher (Research)	Harvard Medical School, United States

2011 - 2013	Research Trainee (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal

Others

	Category Host institution	Employer
2018/04 - 2021	Research Fellow - Project PPBI - Portuguese Platform of BioImaging	Universidade de Coimbra Faculdade de Medicina, Portugal

2016/01 - 2016/03	Visiting Student	Newcastle University Institute for Cell and Molecular Biosciences, United Kingdom

2015/02 - 2015/04	Visiting Student	University of Liverpool Department of Cellular and Molecular Physiology, United Kingdom

Projects

Contract

	Designation	Funders
2022/01/01 - 2023/12/31	ConCOEUR: Unveiling the impact of Connexin43 (Cx43)-mediated gene expression at the crossroads of aortic valve stenosis and left ventricle hypertrophy EXPL/MED-OUT/0590/2021 10.54499/EXPL/MED-OUT/0590/2021 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Other

	Designation	Funders
2018/07/26 - 2021/07/25	On the right side: unveiling the mechanisms of pulmonary hypertension reversability and the heart failure progression PTDC/MEC-CAR/32414/2017 Researcher Universidade de Coimbra, Portugal Centro Hospitalar e Universitário de Coimbra EPE, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/22 - 2021/06/21	A novel mechanism to re-pair Heart Failure with preserved Ejection Fraction (HFpEF) and endothelial damage PTDC/MED-PAT/32179/2017 Researcher Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Book chapter

Teresa M Ribeiro-Rodrigues; George Kelly; Viktor I. Korolchuk; Henrique Girao. "Intercellular communication and aging". 257-274. Elsevier, 2023.
10.1016/b978-0-12-823761-8.00005-7
Batista-Almeida, Daniela; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Girao, Henrique. "The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication". In Advances in Experimental Medicine and Biology, 279-302. Springer International Publishing, 2020.
Published • 10.1007/978-3-030-38266-7_12
Martins-Marques, Tania; Anjo, Sandra I.; Ribeiro-Rodrigues, Teresa; Manadas, Bruno; Girao, Henrique. "Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein". In Methods in Molecular Biology, 151-172. Springer New York, 2017.
10.1007/978-1-4939-7057-5_12
Quinas-Guerra, M. M.; Ribeiro-Rodrigues, T. M.; Rodríguez-Manzaneque, Juan Carlos; Travasso, Rui D. M.. "Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach". In Systems Biology in Cancer Research and Drug Discovery, 197-227. Springer Netherlands, 2012.
Published • 10.1007/978-94-007-4819-4_8

Journal article

Sara F.F. Almeida; Alexandra Fonseca; José Sereno; Hugo R. S. Ferreira; Mariana Lapo-Pais; Tânia Martins-Marques; Teresa M Ribeiro-Rodrigues; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small (2022): 2203999-2203999. http://dx.doi.org/10.1002/smll.202203999.
10.1002/smll.202203999
Amorim M; Martins B; Caramelo F; Gonçalves C; Trindade G; Simão J; Barreto P; et al. "Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/35692536.
10.3389/fmed.2022.873483
Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules (2021): https://doi.org/10.3390/biom11060770.
10.3390/biom11060770
Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.". Autophagy (2021): http://europepmc.org/abstract/med/33634751.
10.1080/15548627.2020.1797280
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; de Jager, Saskia C; Zuzarte, Monica; Ferreira, Cátia; Cruz, Pedro; Reis, Liliana; et al. "Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes". Life Science Alliance 3 12 (2020): e202000821. http://dx.doi.org/10.26508/lsa.202000821.
10.26508/lsa.202000821
Gaspar LS; Santana MM; Henriques C; Pinto MM; Ribeiro-Rodrigues TM; Girão H; Nobre RJ; Pereira de Almeida L. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.". Molecular therapy. Methods & clinical development (2020): http://europepmc.org/abstract/med/32913880.
10.1016/j.omtm.2020.07.012
Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245.
10.1002/glia.23880
Pereira, Patricia M. R.; Parada, Belmiro; Ribeiro-Rodrigues, Teresa M.; Fontes-Ribeiro, Carlos A.; Girão, Henrique; Tome, Joao P. C.; Fernandes, Rosa. "Caveolin-1 modulation increases efficacy of a galacto-conjugated phthalocyanine in bladder cancer cells resistant to photodynamic therapy". Molecular Pharmaceutics (2020): http://dx.doi.org/10.1021/acs.molpharmaceut.0c00298.
Accepted • 10.1021/acs.molpharmaceut.0c00298
Catarino, Steve; Ribeiro-Rodrigues, Teresa M; Sá Ferreira, Rita; Ramalho, José; Abert, Christine; Martens, Sascha; Girão, Henrique. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells 9 4 (2020): 902. http://dx.doi.org/10.3390/cells9040902.
10.3390/cells9040902
Batista-Almeida, Daniela; Ribeiro-Rodrigues, Teresa; Martins-Marques, Tânia; Cortes, Luisa; Antunes, Manuel J.; Antunes, Pedro E.; Gonçalves, Lino; et al. "Ischaemia impacts TNT-mediated communication between cardiac cells". Current Research in Cell Biology 1 (2020): 100001. http://dx.doi.org/10.1016/j.crcbio.2020.04.001.
10.1016/j.crcbio.2020.04.001
Ferreira, Joao Vasco; Rosa Soares, Ana; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, Paulo. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790. http://dx.doi.org/10.1371/journal.pone.0223790.
10.1371/journal.pone.0223790
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Batista-Almeida, Daniela; Aasen, Trond; Kwak, Brenda R.; Girao, Henrique. "Biological Functions of Connexin43 Beyond Intercellular Communication". Trends in Cell Biology 29 10 (2019): 835-847. http://dx.doi.org/10.1016/j.tcb.2019.07.001.
10.1016/j.tcb.2019.07.001
Almeida Paiva R; Martins-Marques T; Jesus K; Ribeiro-Rodrigues T; Zuzarte M; Silva A; Reis L; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation.". Journal of cellular and molecular medicine (2018): http://europepmc.org/abstract/med/30516028.
10.1111/jcmm.14014
Delgado-Silva J; Fernandes R; Pita IR; Pereira FC; Jaguszewski M; Gutiérrez-Chico JL; Ribeiro-Rodrigues T; et al. "Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery.". Hypertension research : official journal of the Japanese Society of Hypertension (2018): http://europepmc.org/abstract/med/30006641.
10.1038/s41440-018-0072-y
Ribeiro-Rodrigues, Teresa M.; Martins-Marques, Tânia; Morel, Sandrine; Kwak, Brenda R.; Girão, Henrique. "Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes". Journal of Cell Science 130 21 (2017): 3619-3630. http://dx.doi.org/10.1242/jcs.200667.
10.1242/jcs.200667
Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
10.1093/cvr/cvx118
Melo, Tânia; Domingues, Pedro; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Segundo, Marcela A.; Domingues, M. Rosário M.. "Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach". Free Radical Biology and Medicine 106 (2017): 219-227. http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.033.
10.1016/j.freeradbiomed.2017.02.033
Da Silva-Ferrada, Elisa; Ribeiro-Rodrigues, Teresa M.; Rodríguez, Manuel S.; Girão, Henrique. "Proteostasis and SUMO in the heart". The International Journal of Biochemistry & Cell Biology 79 (2016): 443-450. http://dx.doi.org/10.1016/j.biocel.2016.09.015.
10.1016/j.biocel.2016.09.015
Sousa, Bebiana; Melo, Tânia; Campos, Ana; Moreira, Ana S.P.; Maciel, Elisabete; Domingues, Pedro; Carvalho, Rita Pereira; et al. "Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia". Journal of Cellular Physiology 231 10 (2016): 2266-2274. http://dx.doi.org/10.1002/jcp.25344.
10.1002/jcp.25344
Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
10.1038/srep13243
Santos-Oliveira, Patrícia; Correia, António; Rodrigues, Tiago; Ribeiro-Rodrigues, Teresa M; Matafome, Paulo; Rodríguez-Manzaneque, Juan Carlos; Seiça, Raquel; Girão, Henrique; Travasso, Rui D. M.. "The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis". PLOS Computational Biology 11 8 (2015): e1004436. http://dx.doi.org/10.1371/journal.pcbi.1004436.
10.1371/journal.pcbi.1004436
Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
10.1042/bst20150036
Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
10.1016/j.biochi.2015.02.020
Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
10.1089/dna.2014.2765
Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
10.1096/fj.13-248963

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2017 - 2018	Stents, statins and sirolimus: a new approach to prevent restenosis Co-supervisor	Medicina (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015	Exosomes release by cardiomyocytes modulate angiogenic response in heart ischemia Co-supervisor	Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal

Distinctions

Award

2022	Emerging Star Award International Gap Junction Conference , Spain
2019	Research Internship Grant_FLAD Fundação Luso-Americana, Portugal
2013	Young Investigators Award - Basic Science Société Européenne de Cardiologie, France

Other distinction

2016	Short-Term Scientific Mission Grant European Cooperation in Science and Technology, Belgium
2015	Short-Term Scientific Mission Grant European Cooperation in Science and Technology, Belgium
2014	Boehringer Ingelheim Fonds Travel Grant Boehringer Ingelheim International GmbH, Germany European Molecular Biology Laboratory, Germany
2014	Travel Grant tebu-bio SAS, France