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I completed my PhD degree in Biosciences in 2014 by Faculty of Sciences and Technology, University of Coimbra. I had two periods abroad: from 2011-2012 at University of Kansas School of Medicine, United States, as an invited PhD student and from 2015-2016 at VIB, Katholieke Universiteit Leuven, Belgium, as a visiting researcher. Currently, I am a doctorate researcher at Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), working at Dr Cláudia Cavadas lab of Neuroendocrinology and Aging. Here, I am devoted to unravel the role of primary cilia, hair-like organelles that project into the cell surface, on Aging and to find anti-aging strategies through the modulation of primary cilia components (Silva & Cavadas, Trends Mol Med., 2023). Despite a maternity leave (2018) and the period of absence from the lab during the Covid-19 pandemic, I have published, in the last 5 years, 14 articles in peer-reviewed journals of which 4 are first author articles (out of 25 published articles plus and 6 sections of books). I have actively tutor several BSc and master students and co-supervised 1 MSc dissertation. I have participated in 1 academic juri and integrate 1 evaluation committe. From 2015 to 2022, I have taught classes on Oxidative stress and Mitochondria in Aging (Master programs from Faculty of Sciences, University of Coimbra) and pratical lessons to Medical degree students under Investigação Aplicada discipline. Since 2023 I collaborate with the Master Programme in Pharmaceutical Biotechnology from the Fcaulty of Pharmacy, University of Coimbra. I have received received 3 awards and/or honors. I participate or have participated as researcher in 8 projects.
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Identificação

Identificação pessoal

Nome completo
Diana Filipa Ferreira da Silva

Nomes de citação

  • Silva, Diana
  • Silva DF

Identificadores de autor

Ciência ID
D514-41E7-3DF1
Google Scholar ID
https://scholar.google.com/citations?user=Fc0lqlsAAAAJ&hl=en

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2019/11/04 - 2019/11/15
Concluído
 Modular Training in Laboratory Animal Science (Diploma de especialização)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Approved
2015/04 - 2019/01
Concluído
 The effect of bacterial Pathogen-Associated Molecular Patterns on Parkinson´s disease-like pathology hallmarks (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014
Concluído
 Doutoramento em Biociências (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial signaling pathway in Alzheimer´s disease: disclosure of new therapeutic targets" (TESE/DISSERTAÇÃO)
 Aprovado com distinção e louvor por unanimidade
2008/09/01 - 2010/07/13
Concluído
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial dysfunction mediated autophagy: relevance to Alzheimer´s disease" (TESE/DISSERTAÇÃO)
 18
2008
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/01 - Atual Investigador Contratado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/04/01 - 2019/01/31 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/08/01 - 2016/07/31 Investigador visitante (Investigação) Katholieke Universiteit Leuven, Bélgica
VIB KU Leuven Center for Brain & Disease Research, Bélgica

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2010/09/01 - 2014/12/15 PhD student with a FCT fellowship (SFRH/BD/62644/2011). Fundação para a Ciência e a Tecnologia, Portugal
2011/11/01 - 2012/06/15 PhD visiting student at Research Institute de Kansas City, USA University of Kansas School of Medicine, Estados Unidos
2009/09/01 - 2010/07/13 Intership/Master thesis development with final classification of 19/20. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2024/09 - Atual Modulation of primary cilia as a new strategy to mitigate aging.
2023.09788.CBM
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2022/08/14 Microbiome-miRNAs axis in Parkinson´s disease: involvement of mitochondial mediated inflammatory response
EXPL/MED-NEU/1515/2021
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2022 The Gut-Brain-Immune system axis in Parkinson´s disease.
PTDC/MED-NEU/3644/2020
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019 - 2021 The role of quality control mechanisms in the loss of proteostasis in age-dependent neurodegenerative disorders
PTDC/MED-NEU/30712/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 The ups and downs of cellular stress: the "MAM hypothesis" for Bipolar disorder pathophysiology.
PTDC/MED-NEU/28214/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2020 The toxinogenic gut microbiome in sporadic Parkinson´s Disease: a quest for new antiPDbiotics.
Prémio Santa Casa Mantero Belard 2016
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Santa Casa da Misericórdia de Lisboa
Em curso
2014 - 2014 Validate tau acetylation as an AD biomarker.
Project GAI
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluído
2010 - 2012 Mitochondrial-dependent impairment of intracellular trafficking in Parkinson´s disease
PTDC/SAU-NEU/102710/2008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2011 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Silva, Diana F.; Esteves, A. Raquel; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M.. "LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease". Redox Biology 63 (2023): 102714. http://dx.doi.org/10.1016/j.redox.2023.102714.
    10.1016/j.redox.2023.102714
  2. D. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Silva, Diana F.; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson´s disease". Cellular and Molecular Life Sciences 80 6 (2023): http://dx.doi.org/10.1007/s00018-023-04819-3.
    10.1007/s00018-023-04819-3
  3. Silva, Diana Filipa; Cavadas, Cláudia. "Primary cilia shape hallmarks of health and aging". Trends in Molecular Medicine (2023): http://dx.doi.org/10.1016/j.molmed.2023.04.001.
    10.1016/j.molmed.2023.04.001
  4. Magalhães, João D.; Esteves, Ana Raquel; Candeias, Emanuel; Silva, Diana F.; Empadinhas, Nuno; Cardoso, Sandra Morais. "The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson´s Disease". International Journal of Molecular Sciences 24 5 (2023): 4339. http://dx.doi.org/10.3390/ijms24054339.
    10.3390/ijms24054339
  5. Silva DF; Empadinhas, Nuno; Cardoso, Sandra M; Esteves, Ana Raquel. "Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation". Antioxidants (2022):
    Publicado
  6. Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al. "Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria". Gut (2021): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-326023.
    10.1136/gutjnl-2021-326023
  7. Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F.. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease". Biomedicines 9 8 (2021): 881. http://dx.doi.org/10.3390/biomedicines9080881.
    10.3390/biomedicines9080881
  8. Marques, Ana P.; Resende, Rosa; Silva, Diana F.; Batista, Mariana; Pereira, Daniela; Wildenberg, Brigite; Morais, Sofia; et al. "Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients". Biomedicines 9 5 (2021): 522. http://dx.doi.org/10.3390/biomedicines9050522.
    10.3390/biomedicines9050522
  9. Silva DF; Candeias, Emanuel; Ana Raquel Esteves; João D Magalhães; I Luisa Ferreira; Daniela Nunes-Costa; A Cristina Rego; Nuno Empadinhas. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons". Journal of Neuroinflammation 17 (2020): https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-02004-y#Abs1.
    Publicado
  10. Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia. "Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization". Journal of Inorganic Biochemistry (2020): 111039. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039.
    10.1016/j.jinorgbio.2020.111039
  11. Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". Journal of Enzyme Inhibition and Medicinal Chemistry 35 1 (2019): 211-226. http://dx.doi.org/10.1080/14756366.2019.1689237.
    10.1080/14756366.2019.1689237
  12. Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M.. "Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865 8 (2019): 2008-2023. http://dx.doi.org/10.1016/j.bbadis.2018.11.014.
    10.1016/j.bbadis.2018.11.014
  13. Esteves, A. Raquel; Filipe, Filipa; Magalhães, João D.; Silva, Diana F.; Cardoso, Sandra M.. "The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease". Molecular Neurobiology 56 8 (2019): 5654-5670. http://dx.doi.org/10.1007/s12035-019-1483-8.
    10.1007/s12035-019-1483-8
  14. Esteves, Ana R.; Arduíno, Daniela M.; Silva, Diana F.; Viana, Sofia D.; Pereira, Frederico C.; Cardoso, Sandra M.. "Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease". Molecular Neurobiology 55 2 (2017): 1440-1462. http://dx.doi.org/10.1007/s12035-017-0420-y.
    10.1007/s12035-017-0420-y
  15. Silva, D. F.; Esteves, A. R.; Oliveira, C. R.; Cardoso, S. M.. "Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology". Molecular Neurobiology 54 6 (2016): 4021-4040. http://dx.doi.org/10.1007/s12035-016-9951-x.
    10.1007/s12035-016-9951-x
  16. Silva, D. F.; Selfridge, J. E.; Lu, J.; E, L.; Roy, N.; Hutfles, L.; Burns, J. M.; et al. "Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines". Human Molecular Genetics 22 19 (2013): 3931-3946. http://dx.doi.org/10.1093/hmg/ddt247.
    10.1093/hmg/ddt247
  17. F. Silva, D.; Santana, I.; R. Esteves, A.; Baldeiras, I.; M. Arduino, D.; R. Oliveira, C.; M. Cardoso, S.. "Prodromal Metabolic Phenotype in MCI Cybrids: Implications for Alzheimer’s Disease". Current Alzheimer Research 10 2 (2013): 180-190. http://dx.doi.org/10.2174/1567205011310020008.
    10.2174/1567205011310020008
  18. Nunes, Andreia; Marques, Sérgio M.; Quintanova, Catarina; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia. "Multifunctional iron-chelators with protective roles against neurodegenerative diseases". Dalton Transactions 42 17 (2013): 6058. http://dx.doi.org/10.1039/c3dt50406a.
    10.1039/c3dt50406a
  19. Arduíno, Daniela M.; Raquel Esteves, A.; Cortes, Luísa; Silva, Diana F.; Patel, Bindi; Grazina, Manuela; Swerdlow, Russell H.; Oliveira, Catarina R.; Cardoso, Sandra M.. "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic". Human Molecular Genetics 21 21 (2012): 4680-4702. http://dx.doi.org/10.1093/hmg/dds309.
    10.1093/hmg/dds309
  20. M. Arduino, Daniela; Raquel Esteves, A.; F.F. Silva, Diana; Martins-Branco, Diogo; Santos, Daniel; F. Gomes Pimentel, Diana; M. Cardoso, Sandra. "Therapeutic Intervention at Cellular Quality Control Systems in Alzheimers and Parkinsons Diseases". Current Pharmaceutical Design 17 31 (2011): 3446-3459. http://dx.doi.org/10.2174/138161211798072481.
    10.2174/138161211798072481
  21. Silva, Diana F.F.; Esteves, A. Raquel; Arduino, Daniela M.; Oliveira, Catarina R.; Cardoso, Sandra M.. "Amyloid-ß-Induced Mitochondrial Dysfunction Impairs the Autophagic Lysosomal Pathway in a Tubulin Dependent Pathway". Journal of Alzheimer's Disease 26 3 (2011): 565-581. http://dx.doi.org/10.3233/jad-2011-110423.
    10.3233/jad-2011-110423
  22. F.F. Silva, Diana; Raquel Esteves, A.; R. Oliveira, Catarina; M. Cardoso, Sandra. "Mitochondria: The Common Upstream Driver of Amyloid-ß and Tau Pathology in Alzheimer's Disease". Current Alzheimer Research 999 999 (2011): 1-10. http://dx.doi.org/10.2174/1567211212443562050.
    10.2174/1567211212443562050
  23. Esteves, A. R.; Arduíno, D. M.; Silva, D. F. F.; Oliveira, C. R.; Cardoso, S. M.. "Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease 2011 (2011): 1-20. http://dx.doi.org/10.4061/2011/693761.
    10.4061/2011/693761
  24. Branco, Diogo Martins. "Cross-talk between mitochondria and proteasome in Parkinson’s disease pathogenesis". Frontiers in Aging Neuroscience (2010): http://dx.doi.org/10.3389/fnagi.2010.00017.
    10.3389/fnagi.2010.00017
Capítulo de livro
  1. Esteves, A. Raquel; Silva, Diana F.; Santos, Daniel; Candeias, Emanuel; Filipe, Filipa; Cardoso, Sandra M.. "Mitochondria at the Base of Neuronal Innate Immunity in Alzheimer’s and Parkinson’s Diseases". In Mitochondrial Diseases. InTech, 2018.
    10.5772/intechopen.72612
  2. Esteves, Ana Raquel; Silva, Diana F.; G-Fernandes, Maria; Gomes, Rui; Cardoso, Sandra Morais. "Mitochondrial Therapeutic Approaches in Parkinson’s Disease". In Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease, 183-205. Springer International Publishing, 2016.
    10.1007/978-3-319-42139-1_9
  3. Esteves, Ana Raquel; Silva, Diana Filipa; Gonçalves-Fernandes, Maria; Gomes, Rui; Cardoso, Sandra Morais. "Regulation of Autophagy in Parkinson’s Disease". In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 197-212. Elsevier, 2016.
    10.1016/b978-0-12-802937-4.00011-9
  4. Arduino DM; Esteves AR; Martins-Branco, Diogo; Silva DF; Cardoso SM. "Therapeutic intervention at cellular clearance mechanisms: Significance to Parkinson's disease". In Parkinson's Disease: Diagnosis, Treatment and Prognosis. Novapublishers, 2012.
    Publicado
  5. Silva, Diana F.; Selfridge, J. Eva; Lu, Jianghua; E, Lezi; Cardoso, Sandra M.; Swerdlow, Russell H.. "Mitochondrial Abnormalities in Alzheimer’s Disease". In Current State of Alzheimer's Disease Research and Therapeutics, 83-126. Elsevier, 2012.
    10.1016/b978-0-12-394816-8.00003-9
  6. Esteves AR; Arduino DM; Silva DF; Martins-Branco, Diogo; Oliveira CR; Cardoso SM. "MITOCHONDRIAL METABOLISM IN AGE-RELATED NEURODEGENERATIVE DISORDERS: ALZHEIMER’S AND PARKINSON’S REVISITED". In Mitochondria: Structure, Functions and Dysfunctions, editado por Oliver L. Svensson. Nova Science Publishers, Inc., 2009.
    Publicado
Poster em conferência
  1. Silva DF; Ferreira-Marques, Marisa; Cavadas, Claudia. "Modulating primary cilia: a novel strategy to tackle aging". Trabalho apresentado em 3rd RESETaging Conference, 2023.
  2. Silva DF; Candeias, E; Esteves, AR; Magalhães, JD; Empadinhas N; Cardoso, SM. "Cortical neurons exposed to bacteria metabolites develop Alzheimer´s disease-related hallmarks". Trabalho apresentado em 14th¿ International Conference on Alzheimer's and Parkinson's Diseases, 2019.
  3. Silva DF; Esteves, A. Raquel; Candeias, Emanuel; Empadinhas, N; Cardoso, Sandra M. "The neurotoxin ß-METHYLAMINO-L-ALANINE (BMAA) acts on mitochondria to recapitulate PD related pathology". Trabalho apresentado em 8th World Congress on Targeting Mitochondria, 2017.
  4. Silva DF; Esteves, Ana Raquel; Cardoso, Sandra M.. "Mitochondria: the unifying entity from amyloid-ß and Tau pathology to neurodegeneration in sporadic Alzheimer´s disease". Trabalho apresentado em EuroMit 2014 - International Meeting on Mitochondrial Pathology, 2014.
  5. Silva DF; Esteves, A. Raquel; Cardoso, Sandra M.. "Defective mitochondrial function impairs quality control autophagy in a microtubule-dependent pathway in MCI and AD cybrids.". Trabalho apresentado em EMBO Young Scientists Forum, 2013.
  6. Silva DF; Selfridge, J. Eva; Lu, Jianghua; E, Lezi; Cardoso, Sandra M.; Sweedlow, RH. "Mitochondrial biogenesis up-regulation in MCI and AD cybrids.". Trabalho apresentado em The 11th International Conference on Alzheimer´s and Parkinson´s diseases, 2013.
  7. Silva DF; Selfridge, J. Eva; Lu, Jianghua; E, Lezi; Cardoso, Sandra Morais; Swerdlow, Russell H.. "Mitochondrial biogenesis as an adaptive response to mitochondrial dysfunction in MCI and AD cybrids.". Trabalho apresentado em 2nd PF2MUC Symposium, 2012.
  8. Baldeiras, I.; Santana, I.; Proença MT; Garrucho, M.H.; Pascoal, R.; Silva DF; Cardoso, S.M.; et al. "Oxidative damage and progression to Alzheimer´s disease in patients with Mild Cognitive Impairment.". Trabalho apresentado em Alzheimer´s Association International Conference on Alzheimer´s disease, 2010.
Tese / Dissertação
  1. Silva DF. "Mitochondrial signaling pathway in Alzheimer´s disease: disclosure of new therapeutic targets". Doutoramento, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2014.
  2. Silva DF. "Mitochondria de common up-stream driver of Abeta and Tau pathology in Alzheimer´s disease". Mestrado, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2010.

Outros

Outra produção
  1. Invitation to edit in the Special journal Issue: "Connecting the Dots between Oxidative Stress, Gut-Brain Axis and Neurodegenerative Diseases". Topics in this Special Issue include, but are not limited to: Role of gut microbiota in combating or generating oxidative stress. Oxidative stress and inflammation in the pathogenesis of neurodegenerative diseases. Potential interactions between the microbiota-gut-brain axis and the CNS’s oxidative stress. Oxidative stress, microbiome, and gut health Antioxidants and the gut microbiome. 2021. Silva DF. https://www.mdpi.com/journal/antioxidants/special_issues/Dots_Neurodegenerative.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/06/10 Bacterial endotoxin-mediated innate immunity activation through mitochondrial dysfunction in Parkinson´s disease 55th Annual Scientific Meeting (online event)
European Society for Clinical Investigation (Espanha)
2019/05 The gut hypothesis for Alzheimer´s disease: bacterial metabolites cause bioenergetic failure and activation of innate immunity in cortical neurons. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Coimbra, Portugal)
2014/09 Bridging Tau and Amyloid-ß pathologies in sporadic Alzheimer´s disease: mitochondria under the spotlight 2nd International Conference on Alzheimer´s Disease and Dementia
OMICS group (Valencia , Espanha)
2014/06 Mitochondria: the unifying entity from amyloid-ß and Tau pathology to neurodegeneration in sporadic Alzheimer´s disease EuroMit 2014- International Meeting on Mitochondrial Pathology
EuroMit (Tampere, Finlândia)
2013/12 Mitochondria in the road to neurodegeneration in sporadic Alzheimer´s disease. XI Annual CNC Meeting
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2013/05/30 Mitochondrial dysfunction-dependent microtubule depolarization drives autophagic-lysosomal pathway impairment in MCI and AD cybrids XIII Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2011/06 Mitochondrial function and oxidative stress markers in Mild Cognitive Impairment cybrids containing an NT2 neuron-like nuclear background. 25ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Tomar, Portugal)
2010/06/25 Mitochondrial dysfunction-mediated autophagy: relevance to Alzheimer´s disease 24ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência, 25-26 June, Tomar, Portugal
Grupo de Estudos de Envelhecimento Cerebral e Demência (Tomar, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019/09 - 2020/11/13 Mitochondrial impact in innate immunity activation in Parkinson’s disease
Coorientador de Diogo Cardetas Banha
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/03/23 - 2018/03/23 Defining a career plan is a challenging task for young scientists. In the last years, investment by the Government has allowed Life Science and Biomedicine students to pursue a PhD in Portugal, but after graduation many face a future of uncertainty. The symposium Overcoming Challenges in Scientific Careers, the Biomedical Research Post-Doctoral Forum@UC aimed to create an opportunity for PhD holders and PhD students to reflect on their career paths and make informed choices, by contacting and hearing from people of diverse scientific backgrounds (2018/03/23)
Simpósio (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/06/25 c-Src/Fyn- mediated mitochondrial dysfunction in Huntington’s Disease
Arguente principal
 Joana Fernandes dos Santos (Outro)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - 2022 Antioxidants MDPI

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/11/18 - Atual Primary cilia and their relevance in disease mechanisms Master in Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/03/19 - 2022 Mitochondria and Aging. Basic notions of what is aging; the role of mitochondria in controling Aging process; mitochodrial function; mitochondrial DNA; Aging associated diseases - Alzheimer´s and Parkinson´s disease; mitochondrial-dependent activation of innate immunity. Biologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/02/23 - 2022 Investigação Aplicada Mestrado Integrado em Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/04 - 2020/02 Oxidative stress, free radicals and e aging process. Oxidative stress – concepto; free radicals; oxidative species and reactive oxygen species (ROS) – basic notions. Sources of oxidants: mitochondria and phagocytes. Physiological relevance of oxidation: the role of ROS in signaling pathways. Oxidative damage of Biomolecules by ROS. Mechanisms of defense against ROS: enzymatic systems and physiological antioxidants. Evidence of oxidative stress in normal aging: alterations of redox state with aging; lesions accumulation. Ciências de Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/06 - 2026 Member of the PhD committee/external advisor of Inês Moniz during the completion of her PhD in Experimental Biology and Biomedicine (BEB). These committe meets once a year for follow up advisory.
Membro
 Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2019 - Atual International Journal of Molecular Sciences MDPI
2019 - Atual Frontiers in Aging Neuroscience Frontiers
2018 - Atual Biomedicine & Pharmacotherapy Elsevier
2017 - Atual Journal of Alzheimer´s disease IOS Press

Tutoria

Tópico Nome do aluno
2023/02/06 - 2023/05/18 Primary cilia modulation as a new strategy to mitigate aging phenotype of progeria experimental models Francisco Costa
2022/03/07 - 2022/03/25 MITOCHONDRIAL REGULATION OF INNATE IMMUNITY ACTIVATION IN SPORADIC PARKINSON’S DISEASE Laura Nóbrega
2019/09 - 2020/11 MITOCHONDRIAL IMPACT IN INNATE IMMUNITY ACTIVATION IN SPORADIC PARKINSON’S DISEASE Diogo Cardetas Banha
2017/03 - 2017/06 Bacteria metabolites impairment of mitochondrial function in cortical primary neurons Francisco Mano
2014/09 - 2015/07 Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's disease pathology. Rui Gomes
2015/05 - 2015/06 Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology. Luís Gomes
2014/04 - 2014/05 Sirtuin 2 activation modulated by mitochondrial dysfunction Alberto Soares
2014/01 - 2014/04 Mitochondrial dysfunction and autophagy regulation in Alzheimer´s disease Júlia Reis
2009/09 - 2010/07 NAP effect in Alzheimer´s disease rat model Diana Raposo
Distinções

Outra distinção

2014 Best presentation award.
2013 Travel grant from Seahorse Biosciences
Seahorse Biosciences , Portugal
2011 FEBS Youth Travel Fund (YTF) grant