Caio Haddad Franco (E117-7526-DDBF)

Curriculum Vitae

Caio Haddad Franco

Caio H. Franco completed a Ph.D. in Sciences (Major in Microbiology and Immunology) from the Federal University of São Paulo in 2018. He has published 26 articles in peer-reviewed journals, accumulating more than 560 citations to date (accumulated impact factor 185.7, h-factor: 15, Scopus - 2024). The main research developed by C. Franco is in Cell Biology, Microbiology and Parasitology. His main activities are focused on the design and establishment of numerous high-content microscopy assays, performing large-scale screenings with libraries of small molecules/natural products, and phenotypic and genetic characterization of drug-resistant parasites (Trypanosoma cruzi, Plasmodium falciparum). He has also established a screening assay to identify compounds that disrupt/inhibit biofilm formation by Gram-positive bacteria. Recently, C. Franco has investigated factors relevant to S. aureus infection of mammalian cells, through genome-wide microscopy-based screenings; moreover, he has dedicated himself to characterizing the intracellular lifestyle of antibiotic-resistant bacterial strains. He was also the Principal Investigator of an Exploratory Research Project entitled "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains", funded by FCT; the project was developed at the RNA & Infection laboratory (PI: Ana Eulalio - Center for Neurosciences and Cell Biology - University of Coimbra). Since 2023 C. Franco has been working as an Assistant Doctoral Researcher at the Collaborative Laboratory AccelBio, where he is engaged in translational, product-centred drug discovery projects with a focus on high-throughput/high-content assays development, management of compound libraries and performing chemical/genetic screening in relevant human disease models.

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Identificação

Identificação pessoal

Nome completo: Caio Haddad Franco

Nomes de citação

Franco, Caio
Franco, C. H.

Identificadores de autor

Ciência ID: E117-7526-DDBF
ORCID iD: 0000-0003-2467-9401

Moradas

UC Biotech - Biocant Park , 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

https://www.researchgate.net/profile/Caio_Franco (Rede social)
http://lattes.cnpq.br/1083314820023553 (Académico)
https://www.cnc.uc.pt/pt/people/c-franco (Profissional)
https://accelbio.pt/about-us/#team (Profissional)

Domínios de atuação

Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Alemão	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2014/02 - 2018/03 Concluído	Doutorado em Ciências (Doutoramento) Especialização em Microbiology and Immunology Universidade Federal de São Paulo, Brasil "Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening" (TESE/DISSERTAÇÃO)
2007/08 - 2013/08 Concluído	Biotechnology Engineer (Bachelor) Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil "Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds" (TESE/DISSERTAÇÃO)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/01 - Atual	Assistente de Investigação (carreira) (Investigação)	Co-Lab AccelBio, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal (...)
2019/05 - 2022/12	Investigador (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05 - 2019/03	Pós-doutorado (Investigação)	Fundação de Apoio a Universidade de São Paulo, Brasil
	Universidade de São Paulo, Brasil
2012/08 - 2013/06	Estagiário de Investigação (Investigação)	Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
	Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brasil
2011/08 - 2012/07	Estagiário de Investigação (Investigação)	Institut Pasteur Korea, Coreia do Sul
	Institut Pasteur Korea, Coreia do Sul

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2014/02 - 2018/03	PhD fellow	Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
	Centro Nacional de Pesquisa em Energia e Materiais, Brasil (...)
2010/01 - 2011/12	Scientific Trainee Fellow	Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
	Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
2010/08 - 2011/07	Junior Enterprise Organization	Biotec Júnior, Brasil
	Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil

Projetos

Bolsa

	Designação	Financiadores
2022 - 2023	Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains EXPL/BIA-MIC/1251/2021 Investigador responsável Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019 - 2022	Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains POCI-01-0145-FEDER-029999 Bolseiro de Pós-Doutoramento Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018 - 2019	Development of an in vitro antibiofilm screening assay against strains of S. aureus and S. epidermidis FUSP3236 Bolseiro de Pós-Doutoramento Universidade de São Paulo Instituto de Ciencias Biomédicas, Brasil Eurofarma Laboratórios, Brasil	Fundação de Apoio a Universidade de São Paulo Concluído
2017 - 2019	Identification of starting points for drug discovery and target identification against major neglected diseases MMV2016 Bolseiro de Doutoramento Laboratório Nacional de Biociências, Brasil Centro Nacional de Pesquisa em Energia e Materiais, Brasil Universidade de São Paulo, Brasil	Medicines for Malaria Venture Concluído
2014 - 2018	Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening 141635/2014-2 Bolseiro de Doutoramento	Conselho Nacional de Desenvolvimento Científico e Tecnológico
2014 - 2017	NMTrypl - New Drugs for Trypanosomatidic Infections 603240 Bolseiro de Doutoramento Laboratório Nacional de Biociências, Brasil Centro Nacional de Pesquisa em Energia e Materiais, Brasil	European Commission Seventh Framework Programme for Research and Technological Development Regions of Knowledge Concluído
2010 - 2013	Determination of generic doses of ionizing radiation for quarantine treatment 800405 Bolseiro de Iniciação Científica Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brasil	Concluído

Produções

Publicações

Artigo em revista	Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise. "Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives". Frontiers in Drug Discovery 3 (2023): http://dx.doi.org/10.3389/fddsv.2023.1346042. Acesso aberto • Publicado • 10.3389/fddsv.2023.1346042 Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, Caio Haddad; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al. "Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo". Antimicrobial Agents and Chemotherapy 66 11 (2022): http://dx.doi.org/10.1128/aac.00284-22. Publicado • 10.1128/aac.00284-22 Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphaël; Barbosa, Euzébio Guimarães; Panciera, Michele; et al. "In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)". Plants 10 11 (2021): 2235. http://dx.doi.org/10.3390/plants10112235. Publicado • 10.3390/plants10112235 Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al. "Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity". International Journal for Parasitology: Drugs and Drug Resistance 13 (2020): 107-120. http://dx.doi.org/10.1016/j.ijpddr.2020.06.001. Acesso aberto • Publicado • 10.1016/j.ijpddr.2020.06.001 Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia. "Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity". Planta Medica 86 11 (2020): 782-789. http://dx.doi.org/10.1055/a-1179-1003. Publicado • 10.1055/a-1179-1003 Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al. "Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes". International Journal of Molecular Sciences 21 10 (2020): 3659. http://dx.doi.org/10.3390/ijms21103659. Acesso aberto • Publicado • 10.3390/ijms21103659 Bonatto, Vinicius; Batista, Pedro Henrique Jatai; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; et al. "On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors". RSC Medicinal Chemistry 11 11 (2020): 1275-1284. http://dx.doi.org/10.1039/d0md00097c. Publicado • 10.1039/d0md00097c Borsari, Chiara; Jiménez-Antón, María Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan José; Olías-Molero, Ana Isabel; Corral, María Jesús; et al. "Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics". European Journal of Medicinal Chemistry 183 (2019): 111676. http://dx.doi.org/10.1016/j.ejmech.2019.111676. Publicado • 10.1016/j.ejmech.2019.111676 Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al. "Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement". Bioorganic & Medicinal Chemistry 27 22 (2019): 115083. http://dx.doi.org/10.1016/j.bmc.2019.115083. Publicado • 10.1016/j.bmc.2019.115083 Franco, Caio Haddad; Alcântara, Laura Maria; Chatelain, Eric; Freitas-Junior, Lucio; Moraes, Carolina Borsoi. "Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection". Tropical Medicine and Infectious Disease 4 2 (2019): 82. http://dx.doi.org/10.3390/tropicalmed4020082. Acesso aberto • Publicado • 10.3390/tropicalmed4020082 Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al. "Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections". Journal of Medicinal Chemistry 62 8 (2019): 3989-4012. http://dx.doi.org/10.1021/acs.jmedchem.8b02021. Publicado • 10.1021/acs.jmedchem.8b02021 Melo-Filho, Cleber C.; Braga, Rodolpho C.; Muratov, Eugene N.; Franco, Caio Haddad; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Andrade, Carolina Horta. "Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening". European Journal of Medicinal Chemistry 163 (2019): 649-659. http://dx.doi.org/10.1016/j.ejmech.2018.11.062. Publicado • 10.1016/j.ejmech.2018.11.062 Tiago, Rodrigues e Silva; Eugenio, Vaz dos Santos Neto; Ana, Lucia Tasca Goiz Ruiz; Mary, Ann Foglio; Caio, Haddad Franco; Carolina, Borsoi Moraes; Valéria, Maia de Oliveira. "Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir". African Journal of Microbiology Research 12 37 (2018): 897-907. http://dx.doi.org/10.5897/ajmr2018.8940. Publicado • 10.5897/ajmr2018.8940 Bouchmella, Karim; Campanaro, Felipe Davi; Mondo, Gabriela Borba; Santos, Murilo Izidoro; Franco, Caio Haddad; Moraes, Carolina Borsoi; Biolley, Christine; Mehdi, Ahmad; Cardoso, Mateus Borba. "Tetracycline@Silver Ions-Functionalized Mesoporous Silica for High Bactericidal Activity at Ultra-Low Concentration". Nanomedicine 13 14 (2018): 1731-1751. http://dx.doi.org/10.2217/nnm-2018-0027. Publicado • 10.2217/nnm-2018-0027 Machado, Fabricio Castro; Franco, Caio Haddad; dos Santos Neto, Jose Vitorino; Dias-Teixeira, Karina Luiza; Moraes, Carolina Borsoi; Lopes, Ulisses Gazos; Aktas, Bertal Huseyin; Schenkman, Sergio. "Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-23259-9. Acesso aberto • Publicado • 10.1038/s41598-018-23259-9 Silva, Tiago R.; Duarte, Alysson W. F.; Passarini, Michel R. Z.; Ruiz, Ana Lucia T. G.; Franco, Caio Haddad; Moraes, Carolina Borsoi; de Melo, Itamar Soares; et al. "Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities". Polar Biology 41 7 (2018): 1505-1519. http://dx.doi.org/10.1007/s00300-018-2300-y. Publicado • 10.1007/s00300-018-2300-y Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; et al. "Aryl thiosemicarbazones for the treatment of trypanosomatidic infections". European Journal of Medicinal Chemistry 146 (2018): 423-434. http://dx.doi.org/10.1016/j.ejmech.2018.01.043. Publicado • 10.1016/j.ejmech.2018.01.043 Palace-Berl, Fanny; Pasqualoto, Kerly Fernanda Mesquita; Zingales, Bianca; Moraes, Carolina Borsoi; Bury, Mariana; Franco, Caio Haddad; da Silva Neto, Adelson Lopes; et al. "Investigating the structure-activity relationships of N’ -[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds". European Journal of Medicinal Chemistry 144 (2018): 29-40. http://dx.doi.org/10.1016/j.ejmech.2017.12.011. Publicado • 10.1016/j.ejmech.2017.12.011 Silva, Daniel G.; Ribeiro, Jean F.R.; De Vita, Daniela; Cianni, Lorenzo; Franco, Caio Haddad; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; et al. "A comparative study of warheads for design of cysteine protease inhibitors". Bioorganic & Medicinal Chemistry Letters 27 22 (2017): 5031-5035. http://dx.doi.org/10.1016/j.bmcl.2017.10.002. Publicado • 10.1016/j.bmcl.2017.10.002 Balfour, Michael N.; Franco, Caio H.; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Stefani, Hélio A.. "Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols". European Journal of Medicinal Chemistry 128 (2017): 202-212. http://dx.doi.org/10.1016/j.ejmech.2017.01.040. Publicado • 10.1016/j.ejmech.2017.01.040 Borsari, Chiara; Santarem, Nuno; Torrado, Juan; Olías, Ana Isabel; Corral, María Jesús; Baptista, Catarina; Gul, Sheraz; et al. "Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds". European Journal of Medicinal Chemistry 126 (2017): 1129-1135. http://dx.doi.org/10.1016/j.ejmech.2016.12.017. Publicado • 10.1016/j.ejmech.2016.12.017 Silva, Fredson T.; Franco, Caio H.; Favaro, Denize C.; Freitas-Junior, Lucio H.; Moraes, Carolina B.; Ferreira, Elizabeth I.. "Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues". European Journal of Medicinal Chemistry 121 (2016): 553-560. http://dx.doi.org/10.1016/j.ejmech.2016.04.065. Publicado • 10.1016/j.ejmech.2016.04.065 Moraes, Carolina B.; Franco, Caio H.. "Novel drug discovery for Chagas disease". Expert Opinion on Drug Discovery 11 5 (2016): 447-455. http://dx.doi.org/10.1517/17460441.2016.1160883. Publicado • 10.1517/17460441.2016.1160883 Bosc, Damien; Mouray, Elisabeth; Cojean, Sandrine; Franco, Caio Haddad; Loiseau, Philippe M.; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; Grellier, Philippe; Dubois, Joëlle. "Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors". European Journal of Medicinal Chemistry 109 (2016): 173-186. http://dx.doi.org/10.1016/j.ejmech.2015.12.045. Publicado • 10.1016/j.ejmech.2015.12.045 Franco, Caio Haddad; dos Santos, Valter H.M.; Silva, Luciana P.; Arthur, Valter; Silva, Regildo M.G.. "Mutagenic potential of lettuce grown from irradiated seeds". Scientia Horticulturae 182 (2015): 27-30. http://dx.doi.org/10.1016/j.scienta.2014.11.011. Publicado • 10.1016/j.scienta.2014.11.011 Moraes, Carolina B.; Giardini, Miriam A.; Kim, Hwayoung; Franco, Caio H.; Araujo-Junior, Adalberto M.; Schenkman, Sergio; Chatelain, Eric; Freitas-Junior, Lucio H.. "Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development". Scientific Reports 4 1 (2014): http://dx.doi.org/10.1038/srep04703. Publicado • 10.1038/srep04703 Alcantara, Laura M.; Kim, Junwon; Moraes, Carolina B.; Franco, Caio H.; Franzoi, Kathrin D.; Lee, Sukjun; Freitas-Junior, Lucio H.; Ayong, Lawrence S.. "Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites". Experimental Parasitology 134 2 (2013): 235-243. http://dx.doi.org/10.1016/j.exppara.2013.03.022. Publicado • 10.1016/j.exppara.2013.03.022
Capítulo de livro	Ariely Barbosa Leite; Ana Caroline Nascimento Castro; Franco, C. H.; Leila Maria dos Santos Moura; Laura M. Alcantara; Elton J. R. Vasconcelos; Rubens Lima do Monte Neto; Nilmar Silvio Moretti. "Fármacos usados nos tratamentos das protozooses e das ectoparasitoses". In Livro-Texto De Farmacologia - Casos Clínicos E Atividades Didáticas, editado por Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva; Santos, Paulo Caleb Junior de Lima, 1-25. São Paulo, Brasil: Atheneu, 2020. Publicado
Poster em conferência	Franco, Caio; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em RNA biology in host-pathogen interactions - Epiviral conference, 2024. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. Autor correspondente: Alcântara, Laura. "Functional high-throughput screening identifies microRNAs regulating Staphylococcus aureus intracellular lifestyle". Trabalho apresentado em RNA biology in host-pathogen interactions - Epiviral conference, 2024. Costa, Susana; Franco, Caio; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em EMBO \| EMBL Symposium: The non-coding genome, 2023. Franco, C. H.; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em XI ptRNA Meeting - RNA in Disease, 2023. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em XI ptRNA Meeting - RNA in Disease, 2023. Alcântara, Laura; Franco, C. H.; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em Cold Spring Harbor Laboratory Conference Microbial Pathogenesis & Host Response, 2021. Franco, C. H.; Alcântara, Laura; Inês Lopes; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em EMBO \| EMBL Symposium: New Approaches and Concepts in Microbiology, 2021. Tropéia, Naomi; Alcântara, Laura; Franco, Caio; Moraes, Carolina B.; Fisher, Dominique. "Chemical composition and Trypanocidal activity evaluation of the volatile oil from Mentha pulegium L.". Trabalho apresentado em International Phytocosmetics and Phytotherapy Congress/IPPC, 2019. Franco, C. H.; Bruna Wenyi Chuang Jou; Lucio Freitas-Junior; Carolina Borsoi Moraes. "Development of a phenotypic assay and studies of target deconvolution for Staphylococcus aureus and Staphylococcus epidermidis biofilm formation". Trabalho apresentado em II Postdoctoral Symposium from University of São Paulo, 2018. Penteado, A. B.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Singh, A. K. ; Fischer, D. C. H.. "Alkaloid Profile And High Content Screening Trypanocidal Actvity Assay In Annona Species". Trabalho apresentado em VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016. Castro, N. S. V.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Fischer, D. C. H.. "Volatile Oil From Apiaceae Chemical Composition And High Content Screening Trypanocidal Activity Assay". Trabalho apresentado em VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016. Franco, C. H.; Naves, L. S.; Freitas-Junior, L.H.; Moraes, C. B.. "Trypanosoma cruzi high content screening assay: Experimental Standardization and Triage Validation". Trabalho apresentado em XXXI Annual Meeting of the Brazilian Society of Protozoology, 2015. Franco, J. G.; Franco, C. H.; Franco, S. S. H.; Arthur, P. B.; Arthur, V.. "Microwave Radiation Effects on the Different Stages of Sitophilus oryzae (Linné, 1763) (Coleopter, Curculionidae) Evolutive Cycle in Rice, Focusing its Control". Trabalho apresentado em International Nuclear Atlantic Conference - INAC 2013, 2013. Franco, C. H.; Arthur, V.; Franco, S. S. H.; Franco, J. G.; Arthur, P. B.. "Gamma Radiation On The Quality Of Green Bean Minimally Processed". Trabalho apresentado em 21 Simpósio Internacional de Iniciação Científica e Tecnológica da USP, 2013. Franco, C. H.; Valter Arthur; Regildo M.G. Silva; José Gilmar Franco; Suely Salumita Haddad Franco. "Evaluation Of Germination, Vegetative Development And Genotoxicity Of Lettuce From Irradiated Seeds". Trabalho apresentado em International Nuclear Atlantic Conference, 2013. Franco, C. H.; Regildo M.G. Silva; Valter Arthur. "Avaliação do desenvolvimento de mudas de alface (Lactuca sativa L.) provenientes de sementes irradiadas.". Trabalho apresentado em X Encontro de Engenharia Biotecnológica e Biociências, 2010. Franco, C. H.; da Silva. R. M. G.; Arthur, V.; Franco, S. S. H.; Franco, J. G.. "Evaluation of germination and development of Lactuca sativa (Asteracea) from irradiated seeds". Trabalho apresentado em XXII Congresso de Iniciação Científica da Unesp, 2010.
Resumo em conferência	Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Giardini, Miriam A.; Pascoalino, Bruno S.; Freitas-Junior, Lucio H.; et al. "Phenotypic and Genetic Characterization of Trypanosoma cruzi Resistant to Ravuconazole". Trabalho apresentado em XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018. Publicado Alcântara, Laura M.; Ferreira, Talita C. ; Franco, Caio H.; Schenkman, Sergio; Freitas-Junior, Lucio H.; Moraes, Carolina B.. "Screening of the Pathogen Box Library for Discovery of Broad-Spectrum Anti-Trypanosomatidic Agents". Trabalho apresentado em XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018. Publicado Moraes, C; Alcântara, Laura; Kebede, B; Wolf, M; Karunakaran, D; Fontana, V; Ferreira, T.C.S.; et al. "Discovery of anti-leishmanial compounds from natural sources.". Trabalho apresentado em 6th World Congress on Leishmaniasis (World Leish), Toledo, 2017. Publicado
Tese / Dissertação	Franco, C. H.. "Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening". Doutoramento, Universidade Federal de São Paulo, 2018. Franco, C. H.. "Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds". Licenciatura, Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, 2012.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024	Presented the work: Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains	RNA Biology in Host-Pathogens Interactions EpiViral (Porto, Portugal)
2022	Lecturer at PhD Program Course: Image Analysis - Cell profiler	PDBEB course: High-Throughput Screening for Target and Drug Discovery University of Coimbra (Cantanhede, Portugal)
2018	Presented the work: Phenotypic and Genetic Characterization of Trypanosoma cruzi resistant to ravuconazole	XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease Brazilian Society of Protozoology (Caxambu, Brasil)
2017	Presented the work: High content screening of pharmacologically active compounds against Trypanosoma cruzi: impact of different host cell lineages for hit selection	XXXIII Annual Meeting of the Brazilian Society of Protozoology / XLIV Annual Meeting on Basic Research in Chagas Disease Brazilian Society of Protozoology (Caxambu, Brasil)
2015	Invited Speaker - presented the seminar: High Content Screening in Trypanosomes	International Course on Bioimaging by Automated Microscopy Instituto Oswaldo Cruz (Rio de Janeiro, Brasil)
2015	Invited Speaker - presented the Mini-Course: "Studying Neglected Diseases	Open Congress for Biology Students (C.A.E.B) Universidade Estadual de Campinas/ CAEB (Campinas, Brasil)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2021 - 2021	Volunteer Organizer and Speed Dating Presenter of the 2021 edition of European Researchers´s Night - Coimbra (2021/09/24 - 2021/09/24) Exposição (Outra)	Universidade de Coimbra, Portugal
2018 - 2018	Member of the organizing committee of this 2-days international event: Tools and Platforms for phenotypic Drug Discovery (150 attendees) (2018 - 2018) Conferência (Membro da Comissão Organizadora)	Universidade de São Paulo, Brasil Drugs for Neglected Diseases initiative, Suiça
2015 - 2015	Member of the organizing committee of this 2-weeks event: Sao Paulo School of Advanced Science on Neglected Diseases Drug Discovery – focus on Kinetoplastids (80 participants) (2015 - 2015) Outro (Membro da Comissão Organizadora)	Laboratório Nacional de Biociências, Brasil Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil
2015 - 2015	Member of the organizing committee of the meeting Building International Consortia on parasitic diseases: the NMTrypl experience (100 participants) (2015 - 2015) Encontro (Membro da Comissão Organizadora)	Laboratório Nacional de Biociências, Brasil
2011 - 2011	Coordinated the winter course Bioinformatic Applied to Omics (2011 - 2011) Oficina (workshop) (Presidente da Comissão Organizadora)	Biotec Júnior, Brasil

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2024/11/25 - 2024/11/27	Attended the 2024 EU-OPENSCREEN Autumn Training School Oficina (workshop)	EU-OPENSCREEN Autumn Training School EU-OPENSCREEN, Alemanha
2024/09/27 - 2024/09/27	Coordinator of the exhibition "Superbugs: the invisible threat" during the 2024 edition of European Researchers´ Night - Coimbra Exposição	European Researchers´ Night Universidade de Coimbra, Portugal
2024/07/03 - 2024/07/05	Attended the Encontro Ciência 2024 - Science and Technology Summit in Portugal Conferência	Encontro Ciência 2024 Fundação para a Ciência e a Tecnologia, Portugal
2024/02/06 - 2024/02/07	Attended the event Antimicrobial Chemotherapy Conference 2024 Conferência	Antimicrobial Chemotherapy Conference 2024 Global Antibiotic Research and Development Partnership, Suiça British Society for Antimicrobial Chemotherapy, Reino Unido
2023/11/20 - 2023/11/22	Attended the 2023 EU-OPENSCREEN Autumn Training School Outro	2023 Autumn Training School EU-OPENSCREEN, Alemanha
2023/09/29 - 2023/09/29	Coordinator of the exhibition "Superbugs: the invisible threat" during the 2023 edition of European Researchers´ Night - Coimbra Exposição	European Researchers´ Night Universidade de Coimbra, Portugal
2022/11/14 - 2022/11/18	Attended the 2022 EU-OPENSCREEN Autumn Training School Outro	2022 Autumn Training School EU-OPENSCREEN, Alemanha
2022/11 - 2022/11	Attended the workshop "Impulsione o potencial de publicação da sua investigação" Oficina (workshop)	Impulsione o potencial de publicação da sua investigação Fundação para a Ciência e a Tecnologia, Portugal Biblioteca do Conhecimento Online, Portugal The Elsevier Foundation, Países Baixos
2022/09/30 - 2022/09/30	Coordinator of the exhibition "Superbugs: the invisible threat" during the 2022 edition of European Researchers´ Night - Coimbra Exposição	European Researchers´ Night Universidade de Coimbra, Portugal
2022/02/21 - 2022/02/25	Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2022 Oficina (workshop)	PDBEB course: High-Throughput Screening for Target and Drug Discovery Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/06/28 - 2021/06/28	Attended (virtually) the seminar: Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes Seminário	Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes Drug Target Review, Reino Unido
2021/04/27 - 2021/04/27	Attended (virtually) the conference Emerging Infectious Diseases and related environmental, clinical and translational challenges Conferência	Emerging Infectious Diseases and related environmental, clinical and translational challenges Portuguese European Union Presidency , Portugal European Molecular Biology Laboratory, Alemanha
2021/03/23 - 2021/03/23	Attended (virtually) the seminar: High content screening reveals the phenotypic landscape of intestinal organoid regeneration Seminário	Drug Target Review, Reino Unido
2021/02/01 - 2021/02/05	Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2021 Oficina (workshop)	High Throughput Screening For Target And Drug Discovery Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/25 - 2021/01/27	Attended (virtually) to SLAS 2021 - Science Ignite - Digital Conference and Exhibition Conferência	SLAS - 2021 Society for Laboratory Automation and Screening, Estados Unidos
2019/02/04 - 2019/02/04	Attended the workshop "How to get Published" Oficina (workshop)	Researcher Academy On Campus: How to get Published Elsevier BV, Países Baixos Universidade de Coimbra, Portugal
2018/10/31 - 2018/10/31	Attended the international workshop on contemporary concepts on bacterial resistance	Contemporary Concepts on Bacterial Resistance Unión Iberoamericana de Universidades , Espanha
2018/06/06 - 2018/06/06	Attended the international symposium on drug discovery and development held by pharmaceutic companies and research institutes. Simpósio	Drug Discovery in Academia: learning from success and failure Instituto Butantan, Brasil
2017/06/21 - 2017/06/23	Attended a Scientific Meeting: Searching for active compounds against neglected diseases Encontro	III Scientific Meeting - Searching for active compounds against neglected diseases: from traditional knowledge to structural synthesis Universidade de São Paulo, Brasil
2016/06/06 - 2016/06/10	Attended seminars on new approaches to drug discovery against tropical diseases Seminário	New Approaches To Drug Discovery Against Tropical Diseases Universidade Estadual de Campinas, Brasil
2015/06/16 - 2015/06/23	Attended Seminars on Drug Discovery against Neglected Diseases Seminário	Current Drug Discovery for Neglected Diseases Centro Nacional de Pesquisa em Energia e Materiais, Brasil
2014/03/31 - 2014/04/04	Participated on the first Brazilian Meeting of High Content Screening Encontro	1st Brazilian Meeting on High Content Screening Fundação Hemocentro de Ribeirão Preto, Brasil
2014/01/06 - 2014/01/17	Attended the Theoretical and Practical Course on Transmission Electron Microscopy Outro	V Theoretical-Practical Course on Electron Microscopy Laboratório Nacional de Nanotecnologia, Brasil
2011/08/01 - 2012/01/31	Attended the course HOST-PATHOGENS INTERACTIONS at the Centers for Neglected Diseases Drug Discovery Oficina (workshop)	Institut Pasteur Korea Seminars Institut Pasteur Korea, Coreia do Sul
2011/08/01 - 2012/01/31	Attended the course INTRODUCTION TO DRUG DISCOVERY at the Centers for Neglected Diseases Drug Discovery Oficina (workshop)	Institut Pasteur Korea Seminars Institut Pasteur Korea, Coreia do Sul
2011/11/24 - 2011/11/28	Attended a Hands-on workshop in Plant Breeding approaches Oficina (workshop)	II Workshop in Genetics and Plant Breeding Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brasil
2011/05/14 - 2011/05/15	Attended the Basic Design Course: learning basic aspects of Illustrator, Phtotoshop and After Effects Outro	Biotec Jr. Basic Design Course Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
2011/04/29 - 2011/05/01	Attended Seminars on Planning and Managing a Junior Enterprise Encontro	XV Meeting of Junior Enterprises from Unesp Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Franca, Brasil
2010/07/12 - 2010/07/16	Attended the Hands-on workshop in Plant Breeding approaches Oficina (workshop)	I Workshop in Genetics and Plant Breeding Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brasil
2010/06/17 - 2010/06/19	Attended the Workshop on Medicinal Plants Oficina (workshop)	IX Workshop on Medicinal Plants Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brasil
2009/07/20 - 2009/07/24	Attended the workshop Genetic manipulation - General approaches and tools Oficina (workshop)	V Winter Course in Genetics Universidade Estadual de Londrina, Brasil

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/12/06	Master thesis arguer: Identifying New Molecular Modulators of Direct Cardiac Conversion Arguente	Inês da Costa Loureiro (Mestrado) Universidade de Aveiro, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2023 - Atual	Pathogens (2076-0817)	MDPI
2022/09 - 2024/01/01	Frontiers in Drug Discovery (2674-0338)	Frontiers

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2022/11/10 - Atual	Lecturer at MSc Program: discipline Methodologies in Cellular and Molecular Biology	Hands-on: image segmentation and automated image analysis (Mestrado)	Universidade de Coimbra, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2010 - 2011	Secretariat coordinator for the Biotechnology Engineer Students Council	Secretariat Coordinator

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2019 - 2019	Undergraduation Scientific Training Symposium - Poster Session evaluation Membro	Universidade de São Paulo, Brasil

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2023 - Atual	Antibiotics (2079-6382)	MDPI
2022 - Atual	Molecules (1420-3049)	MDPI
2024/03 - 2024/04	Vaccines (2076-393X)	MDPI
2023/03 - 2023/04	Pathogens (2076-0817)	MDPI
2022/10 - 2022/11	Journal of Clinical Medicine (2077-0383)	MDPI
2022/04/15 - 2022/04/21	Journal of Pharmaceutical Research International (2456-9119)	Asia Pacific Publishers
2021/08/01 - 2021/08/31	Asian Hematology Research Journal	OA Academic Press
2021/07/01 - 2021/08/31	Gene Reports (24520144)	Elsevier

Tutoria

	Tópico	Nome do aluno
2024 - Atual	Co-supervision of a PhD student from Universidade de Lisboa (Faculty of Medicine)	David Ferreira
2021/11 - 2022/01	Co-supervised the Applied Biology project of an undergraduate scientific trainee from University of Coimbra (Major em Biology)	Francisca Costa
2018/07 - 2019/03	Co-supervised an undergraduate scientific trainee from University of São Paulo School of Pharmacy.	Bruna Wenyi Chuang Jou
2015/10 - 2016/01	Supervised an undergraduate scientific trainee from Universidade Paulista.	Camila Ferreira
2014/10 - 2015/07	Supervised an undergraduate scientific trainee from Universidade Estadual de Campinas.	Luisa Santos Naves

Distinções

Prémio

2022	MDPI John M Goldsmid Award for Best Research Article 2019-2020 (Drug Discovery for Chagas Disease: Impact of Different Host Cells Lines on Assay Performance and hit Compound Selection) MDPI , Suiça
2018	Postdoctoral fellowship Eurofarma Laboratórios, Brasil Fundação de Apoio a Universidade de São Paulo, Brasil
2014	PhD fellowship Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
2011	Annual Photography Contest Câmara Municipal de Assis, Brasil
2010	Undergraduate scientific training scholarship Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil

Outra distinção

2018	PhD Thesis Defense: Approved with distinction Universidade Federal de São Paulo, Brasil