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Caio H. Franco completed a Ph.D. in Sciences (Major in Microbiology and Immunology) from the Federal University of São Paulo in 2018. He has published 26 articles in peer-reviewed journals, accumulating more than 560 citations to date (accumulated impact factor 185.7, h-factor: 15, Scopus - 2024). The main research developed by C. Franco is in Cell Biology, Microbiology and Parasitology. His main activities are focused on the design and establishment of numerous high-content microscopy assays, performing large-scale screenings with libraries of small molecules/natural products, and phenotypic and genetic characterization of drug-resistant parasites (Trypanosoma cruzi, Plasmodium falciparum). He has also established a screening assay to identify compounds that disrupt/inhibit biofilm formation by Gram-positive bacteria. Recently, C. Franco has investigated factors relevant to S. aureus infection of mammalian cells, through genome-wide microscopy-based screenings; moreover, he has dedicated himself to characterizing the intracellular lifestyle of antibiotic-resistant bacterial strains. He was also the Principal Investigator of an Exploratory Research Project entitled "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains", funded by FCT; the project was developed at the RNA & Infection laboratory (PI: Ana Eulalio - Center for Neurosciences and Cell Biology - University of Coimbra). Since 2023 C. Franco has been working as an Assistant Doctoral Researcher at the Collaborative Laboratory AccelBio, where he is engaged in translational, product-centred drug discovery projects with a focus on high-throughput/high-content assays development, management of compound libraries and performing chemical/genetic screening in relevant human disease models.
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Identification

Personal identification

Full name
Caio Haddad Franco

Citation names

  • Franco, Caio
  • Franco, C. H.

Author identifiers

Ciência ID
E117-7526-DDBF
ORCID iD
0000-0003-2467-9401

Addresses

  • UC Biotech - Biocant Park , 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2014/02 - 2018/03
Concluded
 Doutorado em Ciências (Doutoramento)
Major in Microbiology and Immunology
Universidade Federal de São Paulo, Brazil
"Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening" (THESIS/DISSERTATION)
2007/08 - 2013/08
Concluded
 Biotechnology Engineer (Bachelor)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brazil
"Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2023/01 - Current Research Assistant (Research) Co-Lab AccelBio, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
(...)
2019/05 - 2022/12 Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05 - 2019/03 Postdoc (Research) Fundação de Apoio a Universidade de São Paulo, Brazil
Universidade de São Paulo, Brazil
2012/08 - 2013/06 Research Trainee (Research) Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brazil
2011/08 - 2012/07 Research Trainee (Research) Institut Pasteur Korea, South Korea
Institut Pasteur Korea, South Korea

Others

Category
Host institution 		Employer
2014/02 - 2018/03 PhD fellow Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
Centro Nacional de Pesquisa em Energia e Materiais, Brazil
(...)
2010/01 - 2011/12 Scientific Trainee Fellow Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brazil
2010/08 - 2011/07 Junior Enterprise Organization Biotec Júnior, Brazil
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brazil
Projects

Grant

Designation Funders
2022 - 2023 Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains
EXPL/BIA-MIC/1251/2021
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019 - 2022 Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Post-doc Fellow
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2019 Development of an in vitro antibiofilm screening assay against strains of S. aureus and S. epidermidis
FUSP3236
Post-doc Fellow
Universidade de São Paulo Instituto de Ciencias Biomédicas, Brazil

Eurofarma Laboratórios, Brazil
Fundação de Apoio a Universidade de São Paulo
Concluded
2017 - 2019 Identification of starting points for drug discovery and target identification against major neglected diseases
MMV2016
PhD Student Fellow
Laboratório Nacional de Biociências, Brazil

Centro Nacional de Pesquisa em Energia e Materiais, Brazil

Universidade de São Paulo, Brazil
Medicines for Malaria Venture
Concluded
2014 - 2018 Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening
141635/2014-2
PhD Student Fellow
Conselho Nacional de Desenvolvimento Científico e Tecnológico
2014 - 2017 NMTrypl - New Drugs for Trypanosomatidic Infections
603240
PhD Student Fellow
Laboratório Nacional de Biociências, Brazil

Centro Nacional de Pesquisa em Energia e Materiais, Brazil
European Commission Seventh Framework Programme for Research and Technological Development Regions of Knowledge
Concluded
2010 - 2013 Determination of generic doses of ionizing radiation for quarantine treatment
800405
Scientific Initiation Fellow
Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brazil
Concluded
Outputs

Publications

Book chapter
  1. Ariely Barbosa Leite; Ana Caroline Nascimento Castro; Franco, C. H.; Leila Maria dos Santos Moura; Laura M. Alcantara; Elton J. R. Vasconcelos; Rubens Lima do Monte Neto; Nilmar Silvio Moretti. "Fármacos usados nos tratamentos das protozooses e das ectoparasitoses". In Livro-Texto De Farmacologia - Casos Clínicos E Atividades Didáticas, edited by Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva; Santos, Paulo Caleb Junior de Lima, 1-25. São Paulo, Brazil: Atheneu, 2020.
    Published
Conference abstract
  1. Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Giardini, Miriam A.; Pascoalino, Bruno S.; Freitas-Junior, Lucio H.; et al. "Phenotypic and Genetic Characterization of Trypanosoma cruzi Resistant to Ravuconazole". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018.
    Published
  2. Alcântara, Laura M.; Ferreira, Talita C. ; Franco, Caio H.; Schenkman, Sergio; Freitas-Junior, Lucio H.; Moraes, Carolina B.. "Screening of the Pathogen Box Library for Discovery of Broad-Spectrum Anti-Trypanosomatidic Agents". Paper presented in XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018.
    Published
  3. Moraes, C; Alcântara, Laura; Kebede, B; Wolf, M; Karunakaran, D; Fontana, V; Ferreira, T.C.S.; et al. "Discovery of anti-leishmanial compounds from natural sources.". Paper presented in 6th World Congress on Leishmaniasis (World Leish), Toledo, 2017.
    Published
Conference poster
  1. Franco, Caio; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Paper presented in RNA biology in host-pathogen interactions - Epiviral conference, 2024.
  2. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. Corresponding author: Alcântara, Laura. "Functional high-throughput screening identifies microRNAs regulating Staphylococcus aureus intracellular lifestyle". Paper presented in RNA biology in host-pathogen interactions - Epiviral conference, 2024.
  3. Costa, Susana; Franco, Caio; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Paper presented in EMBO | EMBL Symposium: The non-coding genome, 2023.
  4. Franco, C. H.; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Paper presented in XI ptRNA Meeting - RNA in Disease, 2023.
  5. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in XI ptRNA Meeting - RNA in Disease, 2023.
  6. Alcântara, Laura; Franco, C. H.; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in Cold Spring Harbor Laboratory Conference Microbial Pathogenesis & Host Response, 2021.
  7. Franco, C. H.; Alcântara, Laura; Inês Lopes; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Paper presented in EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology, 2021.
  8. Tropéia, Naomi; Alcântara, Laura; Franco, Caio; Moraes, Carolina B.; Fisher, Dominique. "Chemical composition and Trypanocidal activity evaluation of the volatile oil from Mentha pulegium L.". Paper presented in International Phytocosmetics and Phytotherapy Congress/IPPC, 2019.
  9. Franco, C. H.; Bruna Wenyi Chuang Jou; Lucio Freitas-Junior; Carolina Borsoi Moraes. "Development of a phenotypic assay and studies of target deconvolution for Staphylococcus aureus and Staphylococcus epidermidis biofilm formation". Paper presented in II Postdoctoral Symposium from University of São Paulo, 2018.
  10. Penteado, A. B.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Singh, A. K. ; Fischer, D. C. H.. "Alkaloid Profile And High Content Screening Trypanocidal Actvity Assay In Annona Species". Paper presented in VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016.
  11. Castro, N. S. V.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Fischer, D. C. H.. "Volatile Oil From Apiaceae Chemical Composition And High Content Screening Trypanocidal Activity Assay". Paper presented in VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016.
  12. Franco, C. H.; Naves, L. S.; Freitas-Junior, L.H.; Moraes, C. B.. "Trypanosoma cruzi high content screening assay: Experimental Standardization and Triage Validation". Paper presented in XXXI Annual Meeting of the Brazilian Society of Protozoology, 2015.
  13. Franco, J. G.; Franco, C. H.; Franco, S. S. H.; Arthur, P. B.; Arthur, V.. "Microwave Radiation Effects on the Different Stages of Sitophilus oryzae (Linné, 1763) (Coleopter, Curculionidae) Evolutive Cycle in Rice, Focusing its Control". Paper presented in International Nuclear Atlantic Conference - INAC 2013, 2013.
  14. Franco, C. H.; Arthur, V.; Franco, S. S. H.; Franco, J. G.; Arthur, P. B.. "Gamma Radiation On The Quality Of Green Bean Minimally Processed". Paper presented in 21 Simpósio Internacional de Iniciação Científica e Tecnológica da USP, 2013.
  15. Franco, C. H.; Valter Arthur; Regildo M.G. Silva; José Gilmar Franco; Suely Salumita Haddad Franco. "Evaluation Of Germination, Vegetative Development And Genotoxicity Of Lettuce From Irradiated Seeds". Paper presented in International Nuclear Atlantic Conference, 2013.
  16. Franco, C. H.; Regildo M.G. Silva; Valter Arthur. "Avaliação do desenvolvimento de mudas de alface (Lactuca sativa L.) provenientes de sementes irradiadas.". Paper presented in X Encontro de Engenharia Biotecnológica e Biociências, 2010.
  17. Franco, C. H.; da Silva. R. M. G.; Arthur, V.; Franco, S. S. H.; Franco, J. G.. "Evaluation of germination and development of Lactuca sativa (Asteracea) from irradiated seeds". Paper presented in XXII Congresso de Iniciação Científica da Unesp, 2010.
Journal article
  1. Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise. "Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives". Frontiers in Drug Discovery 3 (2023): http://dx.doi.org/10.3389/fddsv.2023.1346042.
    Open access • Published • 10.3389/fddsv.2023.1346042
  2. Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, Caio Haddad; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al. "Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo". Antimicrobial Agents and Chemotherapy 66 11 (2022): http://dx.doi.org/10.1128/aac.00284-22.
    Published • 10.1128/aac.00284-22
  3. Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphaël; Barbosa, Euzébio Guimarães; Panciera, Michele; et al. "In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)". Plants 10 11 (2021): 2235. http://dx.doi.org/10.3390/plants10112235.
    Published • 10.3390/plants10112235
  4. Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al. "Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity". International Journal for Parasitology: Drugs and Drug Resistance 13 (2020): 107-120. http://dx.doi.org/10.1016/j.ijpddr.2020.06.001.
    Open access • Published • 10.1016/j.ijpddr.2020.06.001
  5. Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia. "Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity". Planta Medica 86 11 (2020): 782-789. http://dx.doi.org/10.1055/a-1179-1003.
    Published • 10.1055/a-1179-1003
  6. Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al. "Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes". International Journal of Molecular Sciences 21 10 (2020): 3659. http://dx.doi.org/10.3390/ijms21103659.
    Open access • Published • 10.3390/ijms21103659
  7. Bonatto, Vinicius; Batista, Pedro Henrique Jatai; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; et al. "On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors". RSC Medicinal Chemistry 11 11 (2020): 1275-1284. http://dx.doi.org/10.1039/d0md00097c.
    Published • 10.1039/d0md00097c
  8. Borsari, Chiara; Jiménez-Antón, María Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan José; Olías-Molero, Ana Isabel; Corral, María Jesús; et al. "Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics". European Journal of Medicinal Chemistry 183 (2019): 111676. http://dx.doi.org/10.1016/j.ejmech.2019.111676.
    Published • 10.1016/j.ejmech.2019.111676
  9. Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al. "Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement". Bioorganic & Medicinal Chemistry 27 22 (2019): 115083. http://dx.doi.org/10.1016/j.bmc.2019.115083.
    Published • 10.1016/j.bmc.2019.115083
  10. Franco, Caio Haddad; Alcântara, Laura Maria; Chatelain, Eric; Freitas-Junior, Lucio; Moraes, Carolina Borsoi. "Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection". Tropical Medicine and Infectious Disease 4 2 (2019): 82. http://dx.doi.org/10.3390/tropicalmed4020082.
    Open access • Published • 10.3390/tropicalmed4020082
  11. Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al. "Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections". Journal of Medicinal Chemistry 62 8 (2019): 3989-4012. http://dx.doi.org/10.1021/acs.jmedchem.8b02021.
    Published • 10.1021/acs.jmedchem.8b02021
  12. Melo-Filho, Cleber C.; Braga, Rodolpho C.; Muratov, Eugene N.; Franco, Caio Haddad; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Andrade, Carolina Horta. "Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening". European Journal of Medicinal Chemistry 163 (2019): 649-659. http://dx.doi.org/10.1016/j.ejmech.2018.11.062.
    Published • 10.1016/j.ejmech.2018.11.062
  13. Tiago, Rodrigues e Silva; Eugenio, Vaz dos Santos Neto; Ana, Lucia Tasca Goiz Ruiz; Mary, Ann Foglio; Caio, Haddad Franco; Carolina, Borsoi Moraes; Valéria, Maia de Oliveira. "Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir". African Journal of Microbiology Research 12 37 (2018): 897-907. http://dx.doi.org/10.5897/ajmr2018.8940.
    Published • 10.5897/ajmr2018.8940
  14. Bouchmella, Karim; Campanaro, Felipe Davi; Mondo, Gabriela Borba; Santos, Murilo Izidoro; Franco, Caio Haddad; Moraes, Carolina Borsoi; Biolley, Christine; Mehdi, Ahmad; Cardoso, Mateus Borba. "Tetracycline@Silver Ions-Functionalized Mesoporous Silica for High Bactericidal Activity at Ultra-Low Concentration". Nanomedicine 13 14 (2018): 1731-1751. http://dx.doi.org/10.2217/nnm-2018-0027.
    Published • 10.2217/nnm-2018-0027
  15. Machado, Fabricio Castro; Franco, Caio Haddad; dos Santos Neto, Jose Vitorino; Dias-Teixeira, Karina Luiza; Moraes, Carolina Borsoi; Lopes, Ulisses Gazos; Aktas, Bertal Huseyin; Schenkman, Sergio. "Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-23259-9.
    Open access • Published • 10.1038/s41598-018-23259-9
  16. Silva, Tiago R.; Duarte, Alysson W. F.; Passarini, Michel R. Z.; Ruiz, Ana Lucia T. G.; Franco, Caio Haddad; Moraes, Carolina Borsoi; de Melo, Itamar Soares; et al. "Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities". Polar Biology 41 7 (2018): 1505-1519. http://dx.doi.org/10.1007/s00300-018-2300-y.
    Published • 10.1007/s00300-018-2300-y
  17. Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; et al. "Aryl thiosemicarbazones for the treatment of trypanosomatidic infections". European Journal of Medicinal Chemistry 146 (2018): 423-434. http://dx.doi.org/10.1016/j.ejmech.2018.01.043.
    Published • 10.1016/j.ejmech.2018.01.043
  18. Palace-Berl, Fanny; Pasqualoto, Kerly Fernanda Mesquita; Zingales, Bianca; Moraes, Carolina Borsoi; Bury, Mariana; Franco, Caio Haddad; da Silva Neto, Adelson Lopes; et al. "Investigating the structure-activity relationships of N’ -[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds". European Journal of Medicinal Chemistry 144 (2018): 29-40. http://dx.doi.org/10.1016/j.ejmech.2017.12.011.
    Published • 10.1016/j.ejmech.2017.12.011
  19. Silva, Daniel G.; Ribeiro, Jean F.R.; De Vita, Daniela; Cianni, Lorenzo; Franco, Caio Haddad; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; et al. "A comparative study of warheads for design of cysteine protease inhibitors". Bioorganic & Medicinal Chemistry Letters 27 22 (2017): 5031-5035. http://dx.doi.org/10.1016/j.bmcl.2017.10.002.
    Published • 10.1016/j.bmcl.2017.10.002
  20. Balfour, Michael N.; Franco, Caio H.; Moraes, Carolina B.; Freitas-Junior, Lucio H.; Stefani, Hélio A.. "Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols". European Journal of Medicinal Chemistry 128 (2017): 202-212. http://dx.doi.org/10.1016/j.ejmech.2017.01.040.
    Published • 10.1016/j.ejmech.2017.01.040
  21. Borsari, Chiara; Santarem, Nuno; Torrado, Juan; Olías, Ana Isabel; Corral, María Jesús; Baptista, Catarina; Gul, Sheraz; et al. "Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds". European Journal of Medicinal Chemistry 126 (2017): 1129-1135. http://dx.doi.org/10.1016/j.ejmech.2016.12.017.
    Published • 10.1016/j.ejmech.2016.12.017
  22. Silva, Fredson T.; Franco, Caio H.; Favaro, Denize C.; Freitas-Junior, Lucio H.; Moraes, Carolina B.; Ferreira, Elizabeth I.. "Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues". European Journal of Medicinal Chemistry 121 (2016): 553-560. http://dx.doi.org/10.1016/j.ejmech.2016.04.065.
    Published • 10.1016/j.ejmech.2016.04.065
  23. Moraes, Carolina B.; Franco, Caio H.. "Novel drug discovery for Chagas disease". Expert Opinion on Drug Discovery 11 5 (2016): 447-455. http://dx.doi.org/10.1517/17460441.2016.1160883.
    Published • 10.1517/17460441.2016.1160883
  24. Bosc, Damien; Mouray, Elisabeth; Cojean, Sandrine; Franco, Caio Haddad; Loiseau, Philippe M.; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; Grellier, Philippe; Dubois, Joëlle. "Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors". European Journal of Medicinal Chemistry 109 (2016): 173-186. http://dx.doi.org/10.1016/j.ejmech.2015.12.045.
    Published • 10.1016/j.ejmech.2015.12.045
  25. Franco, Caio Haddad; dos Santos, Valter H.M.; Silva, Luciana P.; Arthur, Valter; Silva, Regildo M.G.. "Mutagenic potential of lettuce grown from irradiated seeds". Scientia Horticulturae 182 (2015): 27-30. http://dx.doi.org/10.1016/j.scienta.2014.11.011.
    Published • 10.1016/j.scienta.2014.11.011
  26. Moraes, Carolina B.; Giardini, Miriam A.; Kim, Hwayoung; Franco, Caio H.; Araujo-Junior, Adalberto M.; Schenkman, Sergio; Chatelain, Eric; Freitas-Junior, Lucio H.. "Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development". Scientific Reports 4 1 (2014): http://dx.doi.org/10.1038/srep04703.
    Published • 10.1038/srep04703
  27. Alcantara, Laura M.; Kim, Junwon; Moraes, Carolina B.; Franco, Caio H.; Franzoi, Kathrin D.; Lee, Sukjun; Freitas-Junior, Lucio H.; Ayong, Lawrence S.. "Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites". Experimental Parasitology 134 2 (2013): 235-243. http://dx.doi.org/10.1016/j.exppara.2013.03.022.
    Published • 10.1016/j.exppara.2013.03.022
Thesis / Dissertation
  1. Franco, C. H.. "Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening". PhD, Universidade Federal de São Paulo, 2018.
  2. Franco, C. H.. "Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds". Degree, Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 Presented the work: Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains RNA Biology in Host-Pathogens Interactions
EpiViral (Porto, Portugal)
2022 Lecturer at PhD Program Course: Image Analysis - Cell profiler PDBEB course: High-Throughput Screening for Target and Drug Discovery
University of Coimbra (Cantanhede, Portugal)
2018 Presented the work: Phenotypic and Genetic Characterization of Trypanosoma cruzi resistant to ravuconazole XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease
Brazilian Society of Protozoology (Caxambu, Brazil)
2017 Presented the work: High content screening of pharmacologically active compounds against Trypanosoma cruzi: impact of different host cell lineages for hit selection XXXIII Annual Meeting of the Brazilian Society of Protozoology / XLIV Annual Meeting on Basic Research in Chagas Disease
Brazilian Society of Protozoology (Caxambu, Brazil)
2015 Invited Speaker - presented the seminar: High Content Screening in Trypanosomes International Course on Bioimaging by Automated Microscopy
Instituto Oswaldo Cruz (Rio de Janeiro, Brazil)
2015 Invited Speaker - presented the Mini-Course: "Studying Neglected Diseases Open Congress for Biology Students (C.A.E.B)
Universidade Estadual de Campinas/ CAEB (Campinas, Brazil)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021 - 2021 Volunteer Organizer and Speed Dating Presenter of the 2021 edition of European Researchers´s Night - Coimbra (2021/09/24 - 2021/09/24)
Exhibition (Other)
 Universidade de Coimbra, Portugal
2018 - 2018 Member of the organizing committee of this 2-days international event: Tools and Platforms for phenotypic Drug Discovery (150 attendees) (2018 - 2018)
Conference (Member of the Organising Committee)
 Universidade de São Paulo, Brazil

Drugs for Neglected Diseases initiative, Switzerland
2015 - 2015 Member of the organizing committee of this 2-weeks event: Sao Paulo School of Advanced Science on Neglected Diseases Drug Discovery – focus on Kinetoplastids (80 participants) (2015 - 2015)
Other (Member of the Organising Committee)
 Laboratório Nacional de Biociências, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
2015 - 2015 Member of the organizing committee of the meeting Building International Consortia on parasitic diseases: the NMTrypl experience (100 participants) (2015 - 2015)
Meeting (Member of the Organising Committee)
 Laboratório Nacional de Biociências, Brazil
2011 - 2011 Coordinated the winter course Bioinformatic Applied to Omics (2011 - 2011)
Workshop (President of the Organising Committee)
 Biotec Júnior, Brazil

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11/25 - 2024/11/27 Attended the 2024 EU-OPENSCREEN Autumn Training School
Workshop
 EU-OPENSCREEN Autumn Training School
EU-OPENSCREEN, Germany
2024/09/27 - 2024/09/27 Coordinator of the exhibition "Superbugs: the invisible threat" during the 2024 edition of European Researchers´ Night - Coimbra
Exhibition
 European Researchers´ Night
Universidade de Coimbra, Portugal
2024/07/03 - 2024/07/05 Attended the Encontro Ciência 2024 - Science and Technology Summit in Portugal
Conference
 Encontro Ciência 2024
Fundação para a Ciência e a Tecnologia, Portugal
2024/02/06 - 2024/02/07 Attended the event Antimicrobial Chemotherapy Conference 2024
Conference
 Antimicrobial Chemotherapy Conference 2024
Global Antibiotic Research and Development Partnership, Switzerland

British Society for Antimicrobial Chemotherapy, United Kingdom
2023/11/20 - 2023/11/22 Attended the 2023 EU-OPENSCREEN Autumn Training School
Other
 2023 Autumn Training School
EU-OPENSCREEN, Germany
2023/09/29 - 2023/09/29 Coordinator of the exhibition "Superbugs: the invisible threat" during the 2023 edition of European Researchers´ Night - Coimbra
Exhibition
 European Researchers´ Night
Universidade de Coimbra, Portugal
2022/11/14 - 2022/11/18 Attended the 2022 EU-OPENSCREEN Autumn Training School
Other
 2022 Autumn Training School
EU-OPENSCREEN, Germany
2022/11 - 2022/11 Attended the workshop "Impulsione o potencial de publicação da sua investigação"
Workshop
 Impulsione o potencial de publicação da sua investigação
Fundação para a Ciência e a Tecnologia, Portugal

Biblioteca do Conhecimento Online, Portugal

The Elsevier Foundation, Netherlands
2022/09/30 - 2022/09/30 Coordinator of the exhibition "Superbugs: the invisible threat" during the 2022 edition of European Researchers´ Night - Coimbra
Exhibition
 European Researchers´ Night
Universidade de Coimbra, Portugal
2022/02/21 - 2022/02/25 Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2022
Workshop
 PDBEB course: High-Throughput Screening for Target and Drug Discovery
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/06/28 - 2021/06/28 Attended (virtually) the seminar: Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes
Seminar
 Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes
Drug Target Review, United Kingdom
2021/04/27 - 2021/04/27 Attended (virtually) the conference Emerging Infectious Diseases and related environmental, clinical and translational challenges
Conference
 Emerging Infectious Diseases and related environmental, clinical and translational challenges
Portuguese European Union Presidency , Portugal

European Molecular Biology Laboratory, Germany
2021/03/23 - 2021/03/23 Attended (virtually) the seminar: High content screening reveals the phenotypic landscape of intestinal organoid regeneration
Seminar
Drug Target Review, United Kingdom
2021/02/01 - 2021/02/05 Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2021
Workshop
 High Throughput Screening For Target And Drug Discovery
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/25 - 2021/01/27 Attended (virtually) to SLAS 2021 - Science Ignite - Digital Conference and Exhibition
Conference
 SLAS - 2021
Society for Laboratory Automation and Screening, United States
2019/02/04 - 2019/02/04 Attended the workshop "How to get Published"
Workshop
 Researcher Academy On Campus: How to get Published
Elsevier BV, Netherlands

Universidade de Coimbra, Portugal
2018/10/31 - 2018/10/31 Attended the international workshop on contemporary concepts on bacterial resistance Contemporary Concepts on Bacterial Resistance
Unión Iberoamericana de Universidades , Spain
2018/06/06 - 2018/06/06 Attended the international symposium on drug discovery and development held by pharmaceutic companies and research institutes.
Symposium
 Drug Discovery in Academia: learning from success and failure
Instituto Butantan, Brazil
2017/06/21 - 2017/06/23 Attended a Scientific Meeting: Searching for active compounds against neglected diseases
Meeting
 III Scientific Meeting - Searching for active compounds against neglected diseases: from traditional knowledge to structural synthesis
Universidade de São Paulo, Brazil
2016/06/06 - 2016/06/10 Attended seminars on new approaches to drug discovery against tropical diseases
Seminar
 New Approaches To Drug Discovery Against Tropical Diseases
Universidade Estadual de Campinas, Brazil
2015/06/16 - 2015/06/23 Attended Seminars on Drug Discovery against Neglected Diseases
Seminar
 Current Drug Discovery for Neglected Diseases
Centro Nacional de Pesquisa em Energia e Materiais, Brazil
2014/03/31 - 2014/04/04 Participated on the first Brazilian Meeting of High Content Screening
Meeting
 1st Brazilian Meeting on High Content Screening
Fundação Hemocentro de Ribeirão Preto, Brazil
2014/01/06 - 2014/01/17 Attended the Theoretical and Practical Course on Transmission Electron Microscopy
Other
 V Theoretical-Practical Course on Electron Microscopy
Laboratório Nacional de Nanotecnologia, Brazil
2011/08/01 - 2012/01/31 Attended the course HOST-PATHOGENS INTERACTIONS at the Centers for Neglected Diseases Drug Discovery
Workshop
 Institut Pasteur Korea Seminars
Institut Pasteur Korea, South Korea
2011/08/01 - 2012/01/31 Attended the course INTRODUCTION TO DRUG DISCOVERY at the Centers for Neglected Diseases Drug Discovery
Workshop
 Institut Pasteur Korea Seminars
Institut Pasteur Korea, South Korea
2011/11/24 - 2011/11/28 Attended a Hands-on workshop in Plant Breeding approaches
Workshop
 II Workshop in Genetics and Plant Breeding
Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brazil
2011/05/14 - 2011/05/15 Attended the Basic Design Course: learning basic aspects of Illustrator, Phtotoshop and After Effects
Other
 Biotec Jr. Basic Design Course
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brazil
2011/04/29 - 2011/05/01 Attended Seminars on Planning and Managing a Junior Enterprise
Meeting
 XV Meeting of Junior Enterprises from Unesp
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Franca, Brazil
2010/07/12 - 2010/07/16 Attended the Hands-on workshop in Plant Breeding approaches
Workshop
 I Workshop in Genetics and Plant Breeding
Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brazil
2010/06/17 - 2010/06/19 Attended the Workshop on Medicinal Plants
Workshop
 IX Workshop on Medicinal Plants
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil
2009/07/20 - 2009/07/24 Attended the workshop Genetic manipulation - General approaches and tools
Workshop
 V Winter Course in Genetics
Universidade Estadual de Londrina, Brazil

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/06 Master thesis arguer: Identifying New Molecular Modulators of Direct Cardiac Conversion
(Thesis) Arguer
 Inês da Costa Loureiro (Master)
Universidade de Aveiro, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Antibiotics (2079-6382) MDPI
2022 - Current Molecules (1420-3049) MDPI
2024/03 - 2024/04 Vaccines (2076-393X) MDPI
2023/03 - 2023/04 Pathogens (2076-0817) MDPI
2022/10 - 2022/11 Journal of Clinical Medicine (2077-0383) MDPI
2022/04/15 - 2022/04/21 Journal of Pharmaceutical Research International (2456-9119) Asia Pacific Publishers
2021/08/01 - 2021/08/31 Asian Hematology Research Journal OA Academic Press
2021/07/01 - 2021/08/31 Gene Reports (24520144) Elsevier

Association member

Society Organization name Role
2010 - 2011 Secretariat coordinator for the Biotechnology Engineer Students Council Secretariat Coordinator

Committee member

Activity description
Role 		Institution / Organization
2019 - 2019 Undergraduation Scientific Training Symposium - Poster Session evaluation
Member
 Universidade de São Paulo, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/11/10 - Current Lecturer at MSc Program: discipline Methodologies in Cellular and Molecular Biology Hands-on: image segmentation and automated image analysis (Mestrado) Universidade de Coimbra, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Pathogens (2076-0817) MDPI
2022/09 - 2024/01/01 Frontiers in Drug Discovery (2674-0338) Frontiers

Mentoring / Tutoring

Topic Student name
2024 - Current Co-supervision of a PhD student from Universidade de Lisboa (Faculty of Medicine) David Ferreira
2021/11 - 2022/01 Co-supervised the Applied Biology project of an undergraduate scientific trainee from University of Coimbra (Major em Biology) Francisca Costa
2018/07 - 2019/03 Co-supervised an undergraduate scientific trainee from University of São Paulo School of Pharmacy. Bruna Wenyi Chuang Jou
2015/10 - 2016/01 Supervised an undergraduate scientific trainee from Universidade Paulista. Camila Ferreira
2014/10 - 2015/07 Supervised an undergraduate scientific trainee from Universidade Estadual de Campinas. Luisa Santos Naves
Distinctions

Award

2022 MDPI John M Goldsmid Award for Best Research Article 2019-2020 (Drug Discovery for Chagas Disease: Impact of Different Host Cells Lines on Assay Performance and hit Compound Selection)
MDPI , Switzerland
2018 Postdoctoral fellowship
Eurofarma Laboratórios, Brazil

Fundação de Apoio a Universidade de São Paulo, Brazil
2014 PhD fellowship
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
2011 Annual Photography Contest
Câmara Municipal de Assis, Brazil
2010 Undergraduate scientific training scholarship
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil

Other distinction

2018 PhD Thesis Defense: Approved with distinction
Universidade Federal de São Paulo, Brazil