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Ricardo Alexandre Rodrigues Pires finished his PhD in Materials Science and Engineering in 2004/12/09 by the Technical University of Lisbon, Technical Superior Institute and the graduation in Technological Chemistry in 1998/12/01 by the University of Lisbon, Faculty of Sciences. He is Auxiliary Researcher from the University of Minho and President of the Council of the Unit I3Bs from the University of Minho. He published 45 papers in international scientific journals , 5 book chapters and he registered 4 patents. He co-supervised 1 PhD and 2 MSc thesis. He participates or participated as a researcher in 11 projets and he is responsible for 1 of them. His research is centred in the field of Materials Science and Engineering applied to the biomedical field, in particular in the areas of Neurosciences, Bionanotechnology e Biochemistry. During his research activities he interacted with 150 collaborators in co-autorships of scientific publications. In his CV at Ciência Vitae the most frequent keywords that are related with his professional activities are:: self-assembly; supramolecular systems; hydrogels; Cancer; 3D disease models; metastasis; hyaluronic acid; gastric cancer; peptide/protein aggregation; amyloid; beta-sheet breakers; protein secondary structure; oligomers; nanofibres; ECM mimics. In the past years he has been dedicated to the development of systems able to reduce the cytotoxicity of different types of amyloids present in neurodegenerative disorders, e.g. Alzheimer's Disease. In particular, he is currently developing nanosystems (e.g. dendrimers) that are able to present different chemical moieties (e.g. saccharides and phenolic) and modulate the aggregation of amyloid-beta 42 (Ab42, a hallmark of Alzheimer's Disease), as well as to control the Ab42 cytotoxicity. He his also developing different types of hydrogels using glycosaminoglycans, supramolecular systems generated by short peptide amphiphiles, or their combination to generate mimics of the extracellular matrix of different tissues. These mimics are tuned to be able to recapitulate the biological environment in healthy and pathological (e.g. cancer) states. While the ones that mimic the pathological states (e.g. cancer) are being developed as platforms to study the cancer onset, evolution, invasiveness in response to the hydrogel composition. These hydrogels are also being used to screen the efficacy of different cancer drugs. In the case of the mimics of the extracellular matrix of the healthy cells, the systems are being tested for tissue engineering and regenerative medicine, namely for their capacity to promote the differentiation of stem cells while promoting the regeneration of the target tissue.
Identificação

Identificação pessoal

Nome completo
Ricardo Alexandre Rodrigues Pires

Nomes de citação

  • Pires, Ricardo
  • Pires, Ricardo A
  • Pires, R A

Identificadores de autor

Ciência ID
E511-56A0-F77A
ORCID iD
0000-0002-9197-0138
Researcher Id
A-1595-2009
Scopus Author Id
8129144800

Telefones

Telefone
  • 253510907 (Profissional)

Moradas

  • Universidade do Minho, I3Bs, Grupo 3Bs, Avepark, Zona Industrial da Gandra, 4805-017, Barco, Taipas, Guimarães, Portugal (Profissional)

Websites

  • http://3bs.uminho.pt/ (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2004/12/09
Concluído
Engenharia de Materiais (Doutoramento)
Especialização em Biomateriais
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Ionómeros de Vidro para utilização em medicina dentária: síntese e estudo por técnicas avançadas de espectroscopia e imagem de ressonância magnética nuclear" (TESE/DISSERTAÇÃO)
1998/12/01
Concluído
Química Tecnológica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013/08/01 - Atual Investigador Auxiliar Convidado (carreira) (Investigação) Universidade do Minho, Portugal
2009/01/01 - 2013/12/31 Pós-doutorado (Investigação) Universidade do Minho, Portugal
2005/02/01 - 2008/12/31 Pós-doutorado (Investigação) Universidade do Minho, Portugal
2000/01/01 - 2005/01/31 Investigador (Investigação) Universidade de Lisboa Instituto Superior Técnico, Portugal
1999/01/01 - 1999/12/31 Investigador (Investigação) Universidade de Lisboa Instituto Superior Técnico, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2018/09/19 - Atual Presidente de Conselho de Unidade do I3Bs Universidade do Minho, Portugal
Projetos

Bolsa

Designação Financiadores
2010 - 2012/12 GlueCork - Novos aglomerantes baseados em componentes da cortiça
GlueCork-5396
QREN - FEDER
2010 - 2012/12 WaterCork - Valorização de subprodutos da indústria de cortiça na remoção de contaminantes (orgânicos) em águas
WaterCork-5523
QREN - FEDER

Projeto

Designação Financiadores
2021 - Atual EcaBox - "Eyes in a Care Box": Regenerating human retina from resuscitated cadaveric eyes
964342-EcaBox
Investigador
2021 - 2024/12/31 Inorganic-Templated and Polymeric Layer-by-Layer Microcapsules with Multimodal Drug Loading to Treat Breast Cancer
PTDC/CTM-REF/0022/2020
Investigador
2020 - 2024/03/31 MEPHOS - Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis
872648-MEPHOS
Investigador
2017 - 2024 THE DISCOVERIES CTR – Implementation of the Discoveries Centre for Regenerative and Precision Medicine, a new Centre of Excellence in Portugal
H2020-WIDESPREAD-01-2016-2017-739572
Investigador
Universidade do Minho, Portugal
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
2021 - 2023/03/31 Bio4Cork+ - Technical cork-polymer biocomposites for application in the wine industry
Bio4Cork+
Investigador
2018 - 2021 Self-Healing Hydrogels with Extracellular Matrix Analogues for Cardiac Tissue Engineering
PTDC/BTM-MAT/28327/2017
Investigador responsável
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021 Smart Carbohydrate Nanonets for selective anticancer therapies
PTDC/NAN-MAT/28468/2017
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2017 - 2020 INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micro-nanostructured Patches for myocardIal regeneraTion
M-ERA-NET2/0001/2016
Investigador
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2020 FoReCaST - Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies
FP7-ERAChairs-PilotCall-2013-621399-FoReCaST
Investigador
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
2016 - 2018 CHEM2NATURE – Enabling precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices
H2020-TWINN-2015-692333
Investigador
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
2012 - 2015 POLARIS – Unlocking the research potential of 3Bs Group, University of Minho, in the Nanomedicine field to strengthen its competitive position at the European level
FP7-REGPOT-2012-CT2012-316331
Investigador
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation
2010 - 2012 BioActiveCork - Extracção e isolamento de compostos de elevado potencial biológico de subprodutos da indústria corticeira
BioActiveCork
Investigador
2009 - 2011 NovelComp - Desenvolvimento de novos materiais compósitos cortiça-polímero com base na valorização de resíduos de cortiça
NovelComp-3107
Investigador
2005 - 2008 WaCheUp – New concepts for upgrading pulp and cork mill waste streams to value-added chemicals
NMP2-CT-2005-013896
Investigador
European Commission Sixth Framework Programme
2000 - 2004 Development of new materials in dentistry: synthesis, properties and in-vitro studies using non-invasive advanced techniques
POCTI 33193/FCB/2000
Investigador
Fundação para a Ciência e a Tecnologia
1998 - 2000 Oclusal sealants and dental adhesives: New in-vitro studies using NMR advanced techniques and mechanical spectrometry
PRAXIS XXI - C/SAU/131/96
Investigador
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Barros, Alexandre A. A.; Duarte, Ana Rita C.; Pires, Ricardo A; Lima, Estêvão; Mano, João F.; Reis, Rui L.. "Tailor made degradable ureteral stents from natural origin polysaccharides". Trabalho apresentado em 10th Conference on Supercritical Fluids and Their Applications, 2013.
  2. Mestre, Ana S.; Pires, Ricardo A; Aroso, Ivo; Fernandes, Emanuel M.; Reis, Rui L.; Silva, Susana P.; Carvalho, Ana P.. "Cork-based activated carbons for pharmaceutical compounds removal". Trabalho apresentado em Carbon 2013, 2013.
  3. Fernandes, E.M.; Aroso, I.; Pires, R.A.; Correlo, V.M.; Pitkänen, P.; Koskimies, S.; Mano, J.F.; Reis, R.L.. "Improvement on the mechanical properties of cork composites using suberin as coupling agent through a reactive extrusion process". 2011.
  4. Fernandes, Emanuel M.; Aroso, Ivo; Pires, Ricardo A; Correlo, Vitor M.; Pitkänen, P.; Koskimies, S.; Mano, João F.; Reis, Rui L.. "Improvement on the mechanical properties of cork composites using suberin as coupling agent through a reactive extrusion process". Trabalho apresentado em Annual Technical Conference of the Society of Plastics Engineeres (SPE), 2011.
  5. Pires, R.A.; Abrahams, I.; Nunes, T.G.; Hawkes, G.E.. "31P Nuclear Magnetic Resonance and X-Ray Diffraction Studies of Na-Sr-Phosphate Glass-Ceramics". Trabalho apresentado em Bioceramics, Porto, 2004.
    Publicado
  6. Pires, Ricardo A; Abrahams, Isaac; Nunes, Teresa G.; Hawkes, Geoffrey E.. "31P nuclear magnetic resonance and X-ray diffraction studies of Na-Sr-phosphate glass-ceramics". Trabalho apresentado em Key Engineering Materials, 2004.
  7. Pires, Ricardo A; Nunes, Teresa G.; Hawkes, Geoffrey E.; Abrahams, Isaac. "1H-19F Stray-field Magnetic Resonance Imaging studies of a Commercial Glass Ionomer Cement". Trabalho apresentado em Annals of Magnetic Resonance, 2004.
  8. Ferreira, M. C.; Duarte, Maria L.; Marvão, M. R.; Pires, Ricardo A. "FT-IR Spectroscopy as a tool to determine the degree of acetylation of beta-chitin/chitosan from loligo pen". Trabalho apresentado em Proceedings of the 3rd Asia-Pacific Chitin/Chitosan Symposium, 1998.
Artigo em revista
  1. Ana R. Araújo; Ana C. Araújo; Rui L. Reis; Ricardo A. Pires. "Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria". ACS Biomaterials Science & Engineering (2021): https://doi.org/10.1021/acsbiomaterials.0c01698.
    10.1021/acsbiomaterials.0c01698
  2. Sara Amorim; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials". Trends in Biotechnology (2021): https://doi.org/10.1016/j.tibtech.2020.06.003.
    10.1016/j.tibtech.2020.06.003
  3. Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells". Biomaterials Science (2021): https://doi.org/10.1039/D0BM00843E.
    10.1039/D0BM00843E
  4. Catarina S. Silva; Rute D. Pinto; Sara Amorim; Ricardo A. Pires; Margarida Correia-Neves; Rui L. Reis; Nuno L. Alves; Albino Martins; Nuno M. Neves. "Fibronectin-Functionalized Fibrous Meshes as a Substrate to Support Cultures of Thymic Epithelial Cells". Biomacromolecules (2020): https://doi.org/10.1021/acs.biomac.0c00933.
    10.1021/acs.biomac.0c00933
  5. Sara Amorim; Diana Soares da Costa; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Hyaluronic Acid of Low Molecular Weight Triggers the Invasive Hummingbird Phenotype on Gastric Cancer Cells". Advanced Biosystems 4 11 (2020): 2000122-2000122. https://doi.org/10.1002/adbi.202000122.
    10.1002/adbi.202000122
  6. Sofia Oliveira; Tatiana Felizardo; Sara Amorim; Suzanne M. Mithieux; Ricardo A. Pires; Rui L. Reis; Albino Martins; Anthony S. Weiss; Nuno M. Neves. "Tubular Fibrous Scaffolds Functionalized with Tropoelastin as a Small-Diameter Vascular Graft". Biomacromolecules (2020): https://doi.org/10.1021/acs.biomac.0c00599.
    10.1021/acs.biomac.0c00599
  7. Ana R. Araújo; Sergio Camero; Pablo Taboada; Rui L. Reis; Ricardo A. Pires. "Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure". Chemical Communications (2020): https://doi.org/10.1039/D0CC00192A.
    10.1039/D0CC00192A
  8. Alexandra Brito; Patrícia M. R. Pereira; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse". Nanoscale (2020): https://doi.org/10.1039/D0NR05008C.
    10.1039/D0NR05008C
  9. Sara Amorim; Iva Pashkuleva; Celso A. Reis; Rui L. Reis; Ricardo A. Pires. "Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44". Journal of Materials Chemistry B (2020): https://doi.org/10.1039/D0TB00407C.
    10.1039/D0TB00407C
  10. Alexandra Brito; Patrícia M. R. Pereira; Diana Soares da Costa; Rui L. Reis; Rein V. Ulijn; Jason S. Lewis; Ricardo A. Pires; Iva Pashkuleva. "Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as antagonists of the glucose transporter GLUT1". Chemical Science (2020): https://doi.org/10.1039/D0SC00954G.
    10.1039/D0SC00954G
  11. Helena Almeida; Rui M. A. Domingues; Suzanne M. Mithieux; Ricardo A. Pires; Ana I. Gonçalves; Manuel Gómez-Florit; Rui L. Reis; Anthony S. Weiss; Manuela E. Gomes. "Tropoelastin-Coated Tendon Biomimetic Scaffolds Promote Stem Cell Tenogenic Commitment and Deposition of Elastin-Rich Matrix". ACS Applied Materials & Interfaces (2019): https://doi.org/10.1021/acsami.9b04616.
    10.1021/acsami.9b04616
  12. Alexandra Brito; Yousef M. Abul-Haija; Diana Soares da Costa; Ramon Novoa-Carballal; Rui L. Reis; Rein V. Ulijn; Ricardo A. Pires; Iva Pashkuleva. "Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles". Chemical Science (2019): https://doi.org/10.1039/C8SC04361B.
    10.1039/C8SC04361B
  13. Amorim, Sara; da Costa, Diana Soares; Freitas, Daniela; Reis, Celso A.; Reis, Rui L.; Pashkuleva, Iva; Pires, Ricardo A.. "Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-34445-0.
    10.1038/s41598-018-34445-0
  14. Rui R. Costa; Miguel González-Pérez; Marcos Herrero-Gutiérrez; Ricardo A. Pires; Matilde Alonso; J. Carlos Rodriguez-Cabello; Rui L. Reis; Iva Pashkuleva. "Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00723.
    10.1021/acs.biomac.8b00723
  15. Ana M. Carvalho; Raquel Teixeira; Ramón Novoa-Carballal; Ricardo A. Pires; Rui L. Reis; Iva Pashkuleva. "Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery". Biomacromolecules (2018): https://doi.org/10.1021/acs.biomac.8b00561.
    10.1021/acs.biomac.8b00561
  16. Vieira, Sara; Franco, Albina R.; Fernandes, Emanuel M.; Amorim, Sara; Ferreira, Helena; Pires, Ricardo A.; Reis, Rui L.; Martins, Albino; Neves, Nuno M.. "Fish sarcoplasmic proteins as a high value marine material for wound dressing applications". Colloids and Surfaces B: Biointerfaces 167 (2018): 310-317. http://dx.doi.org/10.1016/j.colsurfb.2018.04.002.
    10.1016/j.colsurfb.2018.04.002
  17. Dudik, Olesia; Leonor, Isabel; Xavier, Joana R.; Rapp, Hans Tore; Pires, Ricardo A.; Silva, Tiago H.; Reis, Rui L.. "Sponge-derived silica for tissue regeneration". Materials Today 21 5 (2018): 577-578. http://dx.doi.org/10.1016/j.mattod.2018.03.025.
    10.1016/j.mattod.2018.03.025
  18. Helena Ferreira; Albino Martins; Marta L. Alves da Silva; Sara Amorim; Susana Faria; Ricardo A. Pires; Rui L. Reis; Nuno M. Neves. "The functionalization of natural polymer-coated gold nanoparticles to carry bFGF to promote tissue regeneration". Journal of Materials Chemistry B (2018): https://doi.org/10.1039/C7TB03273K.
    10.1039/C7TB03273K
  19. Bárbara B. Mendes; Manuel Gómez-Florit; Ricardo A. Pires; Rui M. A. Domingues; Rui L. Reis; Manuela E. Gomes. "Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior". Nanoscale (2018): https://doi.org/10.1039/C8NR04273J.
    10.1039/C8NR04273J
  20. Pires, Ricardo. "OBP fused with cell-penetrating peptides promotes liposomal transduction". Colloids and Surfaces B: Biointerfaces 161 (2018): 645-653. http://www.sciencedirect.com/science/article/pii/S0927776517307622.
    https://doi.org/10.1016/j.colsurfb.2017.11.026
  21. Ivo M. Aroso; Ana R. Araújo; Ricardo A. Pires; Rui L. Reis. "Cork: Current Technological Developments and Future Perspectives for this Natural, Renewable, and Sustainable Material". ACS Sustainable Chemistry & Engineering (2017): https://doi.org/10.1021/acssuschemeng.7b00751.
    10.1021/acssuschemeng.7b00751
  22. Fernandes, João S.; Gentile, Piergiorgio; Crawford, Aileen; Pires, Ricardo A.; Hatton, Paul V.; Reis, Rui L.. "Substituted Borosilicate Glasses with Improved Osteogenic Capacity for Bone Tissue Engineering". Tissue Engineering Part A 23 23-24 (2017): 1331-1342. http://dx.doi.org/10.1089/ten.tea.2016.0386.
    10.1089/ten.tea.2016.0386
  23. João S. Fernandes; Piergiorgio Gentile; Ricardo A. Pires; Rui L. Reis; Paul V. Hatton. "Multifunctional Bioactive Glass and Glass-Ceramic Biomaterials with Antibacterial Properties for Repair and Regeneration of Bone Tissue". Acta Biomaterialia (2017): https://doi.org/10.1016%2Fj.actbio.2017.06.046.
    10.1016/j.actbio.2017.06.046
  24. Aroso, Ivo M.; Araújo, Ana R.; Fernandes, João P.; Santos, Tânia; Batista, Maria T.; Pires, Ricardo A.; Mano, João F.; Reis, Rui L.. "Hydroalcoholic extracts from the bark of Quercus suber L. (Cork): optimization of extraction conditions, chemical composition and antioxidant potential". Wood Science and Technology 51 4 (2017): 855-872. http://dx.doi.org/10.1007/s00226-017-0904-y.
    10.1007/s00226-017-0904-y
  25. João S. Fernandes; Rui L. Reis; Ricardo A. Pires. "Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration". Materials Science and Engineering: C 71 (2017): 252-259. https://doi.org/10.1016/j.msec.2016.10.007.
    10.1016/j.msec.2016.10.007
  26. Araújo, Ana R.; Soares da Costa, Diana; Amorim, Sara; Reis, Rui L.; Pires, Ricardo A.; Pashkuleva, Iva. "Surfaces Mimicking Glycosaminoglycans Trigger Different Response of Stem Cells via Distinct Fibronectin Adsorption and Reorganization". ACS Applied Materials & Interfaces 8 42 (2016): 28428-28436. http://dx.doi.org/10.1021/acsami.6b04472.
    10.1021/acsami.6b04472
  27. Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; Nuno M. Neves. "Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome". RSC Advances 6 115 (2016): 114599-114612. https://doi.org/10.1039/C6RA21623D.
    10.1039/C6RA21623D
  28. Fernandes, Joao S.; Gentile, Piergiorgio; Martins, Margarida; Neves, Nuno M.; Miller, Cheryl; Crawford, Aileen; Pires, Ricardo A.; Hatton, Paul; Reis, Rui L.. "Reinforcement of poly-L-lactic acid electrospun membranes with strontium borosilicate bioactive glasses for bone tissue engineering". Acta Biomaterialia 44 (2016): 168-177. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000385594700015&KeyUID=WOS:000385594700015.
    10.1016/j.actbio.2016.08.042
  29. Fernandes, Joao S.; Martins, Margarida; Neves, Nuno M.; Fernandes, Maria H. V.; Reis, Rui L.; Pires, Ricardo A.. "Intrinsic Antibacterial Borosilicate Glasses for Bone Tissue Engineering Applications". Acs Biomaterials Science & Engineering 2 7 (2016): 1143-1150. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379638200008&KeyUID=WOS:000379638200008.
    10.1021/acsbiomaterials.6b00162
  30. Fernandes, Joao S.; Gentile, Piergiorgio; Moorehead, Robert; Crawford, Aileen; Miller, Cheryl A.; Pires, Ricardo A.; Hatton, Paul V.; Reis, Rui L.. "Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives". Crystal Growth & Design 16 7 (2016): 3731-3740. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379456700023&KeyUID=WOS:000379456700023.
    10.1021/acs.cgd.6b00231
  31. Aroso, Ivo M.; Duarte, Ana Rita C.; Pires, Ricardo R.; Mano, João F.; Reis, Rui L.. "Cork processing with supercritical carbon dioxide: Impregnation and sorption studies". The Journal of Supercritical Fluids 104 (2015): 251-258. http://dx.doi.org/10.1016/j.supflu.2015.06.024.
    10.1016/j.supflu.2015.06.024
  32. Barros, Alexandre A.; Duarte, Ana Rita C.; Pires, Ricardo A.; Sampaio-Marques, Belem; Ludovico, Paula; Lima, Estevao; Mano, Joao F.; Reis, Rui L.. "Bioresorbable ureteral stents from natural origin polymers". Journal of Biomedical Materials Research Part B-Applied Biomaterials 103 3 (2015): 608-617. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351760000014&KeyUID=WOS:000351760000014.
    10.1002/jbm.b.33237
  33. Aroso, Ivo M.; Fernandes, Emanuel M.; Pires, Ricardo A.; Mano, Joao F.; Reis, Rui L.. "Cork extractives exhibit thermo-oxidative protection properties in polypropylene-cork composites and as direct additives for polypropylene". Polymer Degradation and Stability 116 (2015): 45-52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355348800005&KeyUID=WOS:000355348800005.
    10.1016/j.polymdegradstab.2015.03.006
  34. Pires, R.A.; Abul-Haija, Y.M.; Costa, D.S.; Novoa-Carballal, R.; Reis, R.L.; Ulijn, R.V.; Pashkuleva, I.. "Controlling cancer cell fate using localized biocatalytic self-assembly of an aromatic carbohydrate amphiphile". Journal of the American Chemical Society 137 2 (2015): 576-579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921457793&partnerID=MN8TOARS.
    10.1021/ja5111893
  35. Araújo, Ana R.; Pereira, David M.; Aroso, Ivo M.; Santos, Tânia; Batista, Maria T.; Cerqueira, Mariana T.; Marques, Alexandra P.; Reis, Rui L.; Pires, Ricardo A.. "Cork extracts reduce UV-mediated DNA fragmentation and cell death". RSC Advances 5 116 (2015): 96151-96157. http://dx.doi.org/10.1039/c5ra15712a.
    10.1039/c5ra15712a
  36. Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, Joao N.; Reisa, Rui L.; Neves, Nuno M.. "Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering". Biomaterials Science 2 9 (2014): 1195-1209. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341519500006&KeyUID=WOS:000341519500006.
    10.1039/c4bm00069b
  37. Amorim, Sara; Martins, Albino; Neves, Nuno M.; Reis, Rui L.; Pires, Ricardo A.. "Hyaluronic acid/poly-L-lysine bilayered silica nanoparticles enhance the osteogenic differentiation of human mesenchymal stem cells". Journal of Materials Chemistry B 2 40 (2014): 6939-6946. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342994100005&KeyUID=WOS:000342994100005.
    10.1039/c4tb01071j
  38. Pires, Ricardo A; Leonor, Isabel B; Pashkuleva, Iva; Reis, Rui L. "Highlights from the latest articles in nanomedicine.". Nanomedicine (London, England) 9 5 (2014): 573-6. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:24827840&KeyUID=MEDLINE:24827840.
    10.2217/nnm.14.29
  39. Mestre, Ana S.; Pires, Ricardo A.; Aroso, Ivo; Fernandes, Emanuel M.; Pinto, Moises L.; Reis, Rui L.; Andrade, Marta A.; et al. "Activated carbons prepared from industrial pre-treated cork: Sustainable adsorbents for pharmaceutical compounds removal". Chemical Engineering Journal 253 (2014): 408-417. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340213600049&KeyUID=WOS:000340213600049.
    10.1016/j.cej.2014.05.051
  40. Fernandes, E.M.; Pires, R.A.; Mano, J.F.; Reis, R.L.. "Bionanocomposites from lignocellulosic resources: Properties, applications and future trends for their use in the biomedical field". Progress in Polymer Science 38 10-11 (2013): 1415-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885019137&partnerID=MN8TOARS.
    10.1016/j.progpolymsci.2013.05.013
  41. Barros, A.A.A.; Alves, A.; Nunes, C.; Coimbra, M.A.; Pires, R.A.; Reis, R.L.. "Carboxymethylation of ulvan and chitosan and their use as polymeric components of bone cements". Acta Biomaterialia 9 11 (2013): 9086-9097. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885065626&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.06.036
  42. Gomes, F.O.; Pires, R.A.; Reis, R.L.. "Aluminum-free glass-ionomer bone cements with enhanced bioactivity and biodegradability". Materials Science and Engineering C 33 3 (2013): 1361-1370. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873404777&partnerID=MN8TOARS.
    10.1016/j.msec.2012.12.037
  43. Amorim, S.; Pires, R.A.; Da Costa, D.S.; Reis, R.L.; Pashkuleva, I.. "Interactions between exogenous FGF-2 and sulfonic groups: In situ characterization and impact on the morphology of human adipose-derived stem cells". Langmuir 29 25 (2013): 7983-7992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879543962&partnerID=MN8TOARS.
    10.1021/la400871c
  44. Da Costa, D.S.; Pires, R.A.; Frias, A.M.; Reis, R.L.; Pashkuleva, I.. "Sulfonic groups induce formation of filopodia in mesenchymal stem cells". Journal of Materials Chemistry 22 15 (2012): 7172-7178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858972552&partnerID=MN8TOARS.
    10.1039/c2jm15762d
  45. Pires, R.A.; Aroso, I.; Silva, S.P.; Mano, J.F.; Reis, R.L.. "Isolation of friedelin from black condensate of cork". Natural Product Communications 6 11 (2011): 1577-1579. http://www.scopus.com/inward/record.url?eid=2-s2.0-82455191744&partnerID=MN8TOARS.
  46. Pires, R.A.; Mano, J.F.; Reis, R.L.. "Surface properties of extracts from cork black condensate". Holzforschung 64 2 (2010): 217-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-76849098485&partnerID=MN8TOARS.
    10.1515/HF.2010.032
  47. Pires, R.A.; Abrahams, I.; Nunes, T.G.; Hawkes, G.E.. "The role of alumina in aluminoborosilicate glasses for use in glass-ionomer cements". Journal of Materials Chemistry 19 22 (2009): 3652-3660. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249127217&partnerID=MN8TOARS.
    10.1039/b822285a
  48. Pires, R.A.; Nunes, T.G.; Abrahams, I.; Hawkes, G.E.. "The role of aluminium and silicon in the setting chemistry of glass ionomer cements". Journal of Materials Science: Materials in Medicine 19 4 (2008): 1687-1692. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949116779&partnerID=MN8TOARS.
    10.1007/s10856-007-3251-y
  49. Pires, R.A.; Fernandez, C.; Nunes, T.G.. "Structural and spatially resolved studies on the hardening of a commercial resin-modified glass-ionomer cement". Journal of Materials Science: Materials in Medicine 18 5 (2007): 787-796. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248545242&partnerID=MN8TOARS.
    10.1007/s10856-006-0010-4
  50. Pires, R.A.; Abrahams, I.; Nunes, T.G.; Hawkes, G.E.. "Multinuclear magnetic resonance studies of borosilicate glasses for use in glass ionomer cements: Incorporation of CaO and Al2O3". Journal of Materials Chemistry 16 24 (2006): 2364-2373. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745023550&partnerID=MN8TOARS.
    10.1039/b601593j
  51. Pires, R.; Nunes, T.G.; Abrahams, I.; Hawkes, G.E.; Morais, C.M.; Fernandez, C.. "Stray-field imaging and multinuclear magnetic resonance spectroscopy studies on the setting of a commercial glass-ionomer cement". Journal of Materials Science: Materials in Medicine 15 3 (2004): 201-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642263902&partnerID=MN8TOARS.
    10.1023/B:JMSM.0000015479.65516.d0
  52. Pires, R.; Abrahams, I.; Nunes, T.G.; Hawkes, G.E.. "Non-random cation distribution in sodium-strontium-phosphate glasses". Journal of Non-Crystalline Solids 337 1 (2004): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442588520&partnerID=MN8TOARS.
    10.1016/j.jnoncrysol.2004.03.108
  53. Nunes, T.G.; Guillot, G.; Pereira, S.G.; Pires, R.. "1H stray-field long spin-echo trains and MRI: Novel studies on the photopolymerization of a commercial dental resin". Journal of Physics D: Applied Physics 35 11 (2002): 1251-1257. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037035997&partnerID=MN8TOARS.
    10.1088/0022-3727/35/11/323
  54. Nunes, T.G.; Pires, R.; Perdigão, J.; Amorim, A.; Polido, M.. "The study of a commercial dental resin by 1H stray-field magnetic resonance imaging". Polymer 42 19 (2001): 8051-8054. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035908170&partnerID=MN8TOARS.
    10.1016/S0032-3861(01)00296-8
Capítulo de livro
  1. Pires, Ricardo A.; Abul-Haija, Yousef M.; Reis, Rui L.; Ulijn, Rein V.; Pashkuleva, Iva. "Hydrogel Nanomaterials for Cancer Diagnosis and Therapy". In Hydrogels: Design, Synthesis and Application in Drug Delivery & Regenerative Medicine, 170-183. CRC Press, 2018.
    10.1201/9781315152226-10
  2. Brito, Alexandra; Reis, Rui L.; Pires, Ricardo A.; Pashkuleva, Iva. "Sweet building blocks for self-assembling biomaterials with molecular recognition". In Self-assembling Biomaterials, 79-94. Elsevier, 2018.
    10.1016/b978-0-08-102015-9.00005-8
  3. Fernandes, Emanuel M.; Pires, Ricardo A; Reis, Rui L.. "Cork biomass biocomposites: lightweight and sustainable materials". In Lignocellulosic Fibre and Biomass-Based Composite Materials. Elsevier, 2017.
    Publicado
  4. Barros, Alexandre A.; Leite, Álvaro J.; Pires, Ricardo A.; Mano, João F.; Reis, Rui L.. "Bioactive Composites Reinforced with Inorganic Glasses and Glass–Ceramics for Tissue Engineering Applications". In Advances in Calcium Phosphate Biomaterials, 331-353. Springer Berlin Heidelberg, 2014.
    Publicado • 10.1007/978-3-642-53980-0_10
  5. Pereira, David M.; Andrade, Paula B.; Pires, Ricardo A; Reis, Rui L.. "Chemical Ecology of Echinoderms: Impact of Environment and Diet in Metabolomic Profile". In Chemical Ecology of Echinoderms. 2014.
    Publicado
Tese / Dissertação
  1. Fernandes, João Pedro Silva. "Antibacterial glass and glass-biodegradable matrix composites for bone tissue engineering". Doutoramento, 2017. http://hdl.handle.net/1822/48683.

Propriedade Intelectual

Patente
  1. Pires, Ricardo A. 2014. "Stents based on natural polymers produced using clean technologies".
    Pendente
  2. Pires, Ricardo A. 2014. "Extracto hidro-alcoólico de cortiça, processo para a sua preparação, formulações compreendendo o referido extracto e sua utilização".
    Pendente
  3. Pires, Ricardo A. 2009. "Extraction and Purification of Friedelin".
    Pendente
  4. Pires, Ricardo A. 2009. "Extraction of Polyol fractions from cork and cork-derived materials".
    Pendente
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 ECM mimics using modular minimalistic supramolecular systems TERMIS-EU 2019
(Rhodes, Grécia)
2019 Hyaluronan-based 3D extracellular matrix model to study cancer progression TERMIS-EU 2019
(Rhodes, Grécia)
2019 Natural aromatic small molecules redesign toxic soluble aß42 oligomers TERMIS-EU 2019
(Rhodes, Grécia)
2019 Vescalagin/castalagin reduces Aß42 cytotoxicity through the modulation of its aggregation pathway Integrative Approaches to Protein Folding & Aggregation
(Lisboa, Portugal)
2019 Hyaluronan molecular weight regulates cancer cell migration and invasiveness 2nd FORECAST Workshop
(Porto, Portugal)
2019 Carbohydrate toolbox for the supramolecular (dis)assembly in nanomedicine GLUPOR 13
(Porto, Portugal)
2019 Biocatalytic self-assembly of supramolecular gels is controlled by the choice of the amphiphile regioisomer European Society for Biomaterials 2019
(Dresden, Alemanha)
2019 Glucose amphiphiles as metabolic inhibitors in cancer GLUPOR 13
(Porto, Portugal)
2019 Hyaluronan molecular weight regulates the dynamics of focal adhesions and cancer cell migration and invasiveness GLUPOR 13
(Porto, Portugal)
2019 Supramolecular inhibition of Aß42 intermediates by GlcN analogues GLUPOR 13
(Porto, Portugal)
2019 Carbohydrate stereoisomers self-assemble into supramolecular fibers with different helicity GLUPOR 13
(Porto, Portugal)
2018 Self-assembling carbohydrate amphiphiles for biomedical applications HUJI Nano-Center Annual Conference
(Jerusalem, Israel)
2018 Self-Assembly Glycan Amphiphiles for Biomedical Applications 3rd Asian University Symposium on Biomedical Engineerin
(Coreia do Sul)
2018 Co-assembly of peptide and carbohydrate amphiphiles to generate proteoglycan mimics 256th ACS National Meeting
(Boston, Estados Unidos)
2018 Cork: a source of (bio)active compounds 3rd Chem2Nature Workshop

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2011 - 2017 Smart Materials Based on Polyester-Glass Composites for Bone Tissue Engineering
Coorientador
Materials Science and Engineering (Doutoramento)
2012 - 2012 Carboxylated polysaccharides as the polymeric component of Glass-Ionomer Cements
Coorientador
Properties and Technology of Polymers (Mestrado)
2010 - 2011 Bone cements – development of partially degradable ionomer cements
Coorientador
Characterization and Analytical Chemistry Techniques (Mestrado)
Distinções

Prémio

2021 Young Biophysicist Prize 2021 (Awarded to the PhD student Ana Rita Araújo - Supervised by Ricardo A. Pires)
2007 BES Inovação in the area of Forestry
Banco Espírito Santo e Comercial de Lisboa, Portugal