Artigo em conferência |
- Costa, Cláudia; Cunha, Sara; Peixoto, Andreia; Moreira, João Nuno; Sousa Lobo, José; Silva, Ana. "Application of the quality-by-design
(QbD) approach to improve the nose-to-brain delivery of diazepam-loaded nanostructured lipid carriers (NLC)". 2020.
https://doi.org/10.3390/IECP2020- 08658
- Chiara, Brignole; Bensa, Veronica; Zotto, Genny Del; Bruno, Silvia; Fonseca, Nuno A; Cruz, Ana F; Paolo, Daniela Di; et al.
"Nucleolin: A novel cell surface protein for neuroblastoma targeted therapy". Trabalho apresentado em AACR-NCI-EORTC International
Conference on Molecular Targets and Cancer Therapeutics, Boston, 2019.
10.1158/1535-7163.targ-19-a101
- Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Signorino, Giacomo; Focareta, Laura; Fucci, Alessandra; et
al. "In vivo targeting of mesothelioma’s molecular signature with nanoparticle functionalized with nucleolin-binding peptide".
Trabalho apresentado em 110th Annual Meeting of the American Association for Cancer Research, Atlanta, 2019.
Publicado • 10.1158/1538-7445.am2019-2994
- Cruz, Ana F.; Fonseca, Nuno A.; Gonçalves, Nélio; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Differential effect of
liposomal C6-ceramide/doxorubicin targeted to nucleolin and conventional combinations against triple negative breast cancer
stem cells". Trabalho apresentado em 10th Annual Meeting of the American Association for Cancer Research, Atlanta,
2019.
Publicado • 10.1158/1538-7445.am2019-3622
- Marta Isabel Pereira; João T. Barata; Ana Bela Sarmento-Ribeiro; Moreira, João Nuno. "The prognostic impact of nucleolin
overexpression in hematologic neoplasms.". Trabalho apresentado em Annual Meeting of the Portuguese Society of Hematology,
Vilamoura, 2019.
Publicado
- Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Cardile, Francesco; Pisano, Claudio; Simões, Sérgio; Moreira,
João Nuno. "Targeting nucleolin with doxorubicin-containing nanoparticle induces a significant tumor growth inhibition in
an orthotopic animal model of standard of care-resistant mesothelioma". Trabalho apresentado em AACR Annual Meeting 2017,
Washington DC, 2017.
Publicado • 10.1158/1538-7445.am2017-5155
- Cruz, Ana Filipa; Fonseca, Nuno A.; Sampaio, Susana F.; Moura, Vera; Almeida, Ramiro D.; Simões, Sérgio; Moreira, João Nuno.
"Synergistic cytotoxicity of targeted liposomes containing doxorubicin and C6-ceramide against nucleolin-overexpressing ovarian
cancer cells is supported by the downregulation of the Akt pathway". Trabalho apresentado em AACR Annual Meeting 2017,
Washington DC, 2017.
Publicado • 10.1158/1538-7445.am2017-2194
- Balça-Silva, Joana; do Carmo, Anália; Sarmento-Ribeiro, A. B.; Moura-Neto, Vivaldo; Lopes, Maria Celeste; Moreira, João Nuno.
"Nucleolin overexpression in glioblastoma stem-like cells enables targeted intracellular delivery and improves cytotoxicity".
Trabalho apresentado em : 41st FEBS Congress - Molecular and Systems Biology for a Better Life, Ephesus, 2016.
10.1111/febs.2016.283.issue-S1 /react-text react-text: 53 /react-text react-text: 54 /react-text react-text: 55
- Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.;
Moreira, João Nuno. "Targeting Nucleolin in Lung Cancer: an emerging strategy to overcome stroma-mediated anti-VEGF resistance".
Trabalho apresentado em 23rd Biennial Congress of the European Association for Cancer Research (EACR-23): From Basic Research
to Personalised Cancer Treatment, Munich, 2014.
Publicado
- Valério-Fernandes, Ângela; Fonseca, Nuno; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina; Simões,
Sérgio; Moreira, João Nuno. "Targeting nucleolin: A potential strategy to overcome stroma-mediated bevacizumab resistance
in lung cancer.". Trabalho apresentado em American Association for Cancer Research (AACR) Annual Meeting 2014: Harnessing
Breakthroughs - Targeting Cures, San Diego CA, 2014.
Publicado • 10.1158/1538-7445.am2014-3003
- Gregório, A.C.; Fonseca, N.A.; Moura, V.; Domingues, G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias, S.; Moreira, João
Nuno. "Targeting cell-surface nucleolin in metastatic breast cancer.". Trabalho apresentado em EACR23 23rd Biennial Congress
of the European Association for Cancer Research, Munich, 2014.
Publicado
- Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria M E; Soares, Raquel; Simões, Sérgio; Moreira,
João. "A novel targeted triggered release nanoparticle against cancer cells of diverse histological origin.". Trabalho apresentado
em AACR Annual Meeting 2013, Washington DC, 2013.
Publicado • 10.1158/1538-7445.am2013-4521
- Moreira, João Nuno; N. Monteiro; A. Martins; R. Pires; S. Faria; Fonseca, Nuno A.; R. L. Reis; N. M. Neves. "Immobilization
of bioactive factor-loaded liposomes at the surface of electrospun nanofibers targeting tissue engineering strategies". Porto,
2013.
Publicado
- Monteiro N. S.; Martins A.; Ribeiro D.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Induction of Human
Mesenchymal Stem Cells Osteogenesis by Bioactive Agent-Releasing Liposomes". Trabalho apresentado em Term Stem, Guimarães,
2012.
Publicado
- Carvalho, Lina; Alarcão, A; Ladeirinha, Ana; D'Aguiar, MJ; Ferreira, T; Moura, Vera; Lacerda, Manuela; et al. "Nuclear and
cytoplasmic expression of nucleolin depends on accurate validity". Trabalho apresentado em 24th European Congress of Pathology.,
Prague, 2012.
Publicado
- Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, M. Eugenia M.; Soares, Raquel; de Lima, M. Conceicao
Pedroso; Simoes, Sergio; Moreira, Joao Nuno. "Limiting tumor invasion with multifunctional nanoparticle targeting the tumor
microenvironment.". Trabalho apresentado em AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics,
San Francisco, CA, 2011.
10.1158/1535-7163.targ-11-c233
- Figueiredo, Sara; Moreira, João Nuno; Geraldes, CF; Aime, Silvio; Terreno, Enzo. "Gd-loaded yeast cell wall particles: an
innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Torino, 2011.
- Gomes-da-Silva, L.C.; Ramalho, JS; Pedroso de Lima, M.C.; Simões, Sérgio; Moreira, João Nuno. "Targeted Gene Silencing for
Cancer Treatment.". Trabalho apresentado em 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra,
2010.
Publicado
- Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, ME; Maria C. Pedroso de Lima; Simões, Sérgio; Moreira,
João Nuno. "Targeting non-viral vectors to tumor cells and the tumor micronvironment.". Trabalho apresentado em The 16th
International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
Publicado
- Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria Luisa; Cruz, Maria Eugénia; Pedroso de Lima, Maria C.; Simões,
Sérgio; Moreira, João Nuno. "Targeted delivery of therapeutics to tumor cells and the tumor microenvironment". Trabalho apresentado
em AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, 2009.
Publicado • 10.1158/1535-7163.TARG-09-A129
- Carvalho, JFS; Cruz Silva, M.M.; Moreira, João Nuno; Simões, Sérgio; Sa´ e Melo, M. Luisa. "Cytotoxic epoxysterols: chemoenzymatic
synthesis, biological evaluation and SAR.". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets,
Novel Candidates and Innovative Strategies, Barcelona, 2009.
Publicado
- Santos, A.; Pereira, J. P.; Simões, S.; Moreira, João Nuno. "SiRNA mediated downregulation of Bcl-2 in small cell lung cancer
cell lines - impact on protein level and cell viability". Trabalho apresentado em 20th Meeting of the European-Association-for-Cancer-Research,
Lyon, 2008.
Publicado
- Moura, V.; Simões, S.; Pedroso de Lima, M.C.; Moreira, João Nuno. "Novel approaches to breast cancer therapy – simultaneous
targeting to tumor and endothelial cells". Trabalho apresentado em 20th EORTC-NCI-AACR Symposium on Molecular Targets and
Cancer Therapeutics, Geneva, 2008.
Publicado • 10.1016/S1359-6349(08)71990-6
- Pinto, A. C.; Moreira, João Nuno; Simões, S.. "In vitro evaluation of combined effects of conventional and new cytotoxic agents
against a hormone-refractory prostate cancer (HRPC) cell line.". Trabalho apresentado em 7th World Basic Urological Research
Congress - Joint Meeting of the European Society for Urological Research and the Society for Basic Urologic Research,
Dublin, 2007.
Publicado
- Fonseca, Nuno A.; Moreira, João Nuno; Mendonça, L.; Cabrita, A.; Paiva, A.; Lopes, M. T. C.; Pedroso De Lima, M.C.; et al.
"Targeted delivery of antisense oligonucleotides to human T-leukemia cells mediated by novel liposomal formulations: evaluation
of in vitro and in vivo anti-tumoral activity". Trabalho apresentado em 9th Annual Meeting of the American Society of Gene
Therapy, Baltimore, 2006.
Publicado • https://doi.org/10.1016/j.ymthe.2006.08.1059
- Moreira, João Nuno; Gaspar, Rogério; Allen, T. M.. "In vivo targeting of stealth liposomes against human small cell lung cancer.".
Trabalho apresentado em 8th Liposome Research Days Conference., Berlin, 2003.
Publicado
|
Artigo em revista |
- Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo. "Current Insights on Lipid-Based Nanosystems 2023". Pharmaceuticals
(2023): https://doi.org/10.3390/ph16121700.
10.3390/ph16121700
- Ferreira, Débora; Santos-Pereira, Cátia; Costa, Marta; Afonso, Julieta; Yang, Sujuan; Hensel, Janine; McAndrews, Kathleen
M.; et al. "Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells".
Biomaterials Advances 154 (2023): 213643. http://dx.doi.org/10.1016/j.bioadv.2023.213643.
10.1016/j.bioadv.2023.213643
- A.C. Correia; J.N. Moreira; J.M. Sousa Lobo; A.C. Silva. "Design of experiment (DoE) as a quality by design (QbD) tool to
optimize formulations of lipid nanoparticles for nose-to-brain drug delivery". Expert Opinion on Drug Delivery (2023):
https://doi.org/10.1080/17425247.2023.2274902.
10.1080/17425247.2023.2274902
- Pina Costa, Cláudia; Nižic Nodilo, Laura; Silva, Renata; Martins, Eva; Zadravec, Dijana; Kalogjera, Livije; Nuno Moreira,
João; et al. "In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery:
development, characterization and deposition studies in a 3D-printed human nasal cavity model". International Journal of
Pharmaceutics 644 (2023): 123345. http://dx.doi.org/10.1016/j.ijpharm.2023.123345.
Publicado • 10.1016/j.ijpharm.2023.123345
- Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et
al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy
157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021.
Publicado • 10.1016/j.biopha.2022.114021
- Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Giusto, Elena;
et al. "Nucleolin expression has prognostic value in neuroblastoma patients". eBioMedicine 85 (2022): 104300. http://dx.doi.org/10.1016/j.ebiom.2022.104300.
10.1016/j.ebiom.2022.104300
- Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo. "Editorial—Current Insights on Lipid-Based Nanosystems". Pharmaceuticals
(2022): https://doi.org/10.3390/ph15101267.
10.3390/ph15101267
- Correia, A.C.; Monteiro, A.R.; Silva, R.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A.C.. "Lipid nanoparticles strategies
to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB)
to manage neurological disorders". Advanced Drug Delivery Reviews 189 (2022): 114485. http://dx.doi.org/10.1016/j.addr.2022.114485.
10.1016/j.addr.2022.114485
- Ribeiro, Rita; Carvalho, Maria João; Goncalves, João; Moreira, João Nuno. "Immunotherapy in triple-negative breast cancer:
Insights into tumor immune landscape and therapeutic opportunities". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.903065.
Acesso aberto • Publicado • 10.3389/fmolb.2022.903065
- Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Calarco, Enzo;
et al. "Abstract 1276: Nucleolin has prognostic value in neuroblastoma patients". Cancer Research 82 12_Supplem (2022):
1276-1276. http://dx.doi.org/10.1158/1538-7445.am2022-1276.
10.1158/1538-7445.am2022-1276
- Valério-Fernandes, Ângela; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera;
et al. "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention
in Lung Cancer". Cancers 14 9 (2022): 2217. http://dx.doi.org/10.3390/cancers14092217.
10.3390/cancers14092217
- Ferreira, Débora; Moreira, João Nuno; Rodrigues, Lígia R.. "New advances in exosome-based targeted drug delivery systems".
Critical Reviews in Oncology/Hematology 172 (2022): 103628. http://dx.doi.org/10.1016/j.critrevonc.2022.103628.
10.1016/j.critrevonc.2022.103628
- Cruz, Ana Filipa; Fonseca, Nuno A.; Malheiro, Ana Rita; B. Melo, Joana; Gaspar, Maria Manuela; Fernandes, Rui; Moura, Vera;
Simões, Sérgio; Moreira, João Nuno. "Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature
of drug interaction beyond bulk tumor cells". European Journal of Pharmaceutics and Biopharmaceutics 172 (2022): 61-77.
http://dx.doi.org/10.1016/j.ejpb.2022.01.006.
10.1016/j.ejpb.2022.01.006
- Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno (EF1B-FA3D-0787);
Soares, Helena; Corvo, M. Luisa; Cruz, Maria Eugénia M.. "Antagonist G-targeted liposomes for improved delivery of anticancer
drugs in small cell lung carcinoma". International Journal of Pharmaceutics 612 (2022): 121380. http://dx.doi.org/10.1016/j.ijpharm.2021.121380.
10.1016/j.ijpharm.2021.121380
- Cláudia Pina Costa; Sandra Barreiro; João Nuno Moreira; Renata Silva; Hugo Almeida; José Manuel Sousa Lobo; Ana Catarina Silva.
"In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN)". Pharmaceuticals
14 8 (2021): 711-711. https://doi.org/10.3390/ph14080711.
10.3390/ph14080711
- Costa, C.P.; Cunha, S.; Moreira, J. N.; Silva, R.; Gil-Martins, E.; Silva, V.; Azevedo, L.; et al. "Quality by design (QbD)
optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: toxicological effect of surface
charge on human neuronal cells". International Journal of Pharmaceutics (2021): 120933. http://dx.doi.org/10.1016/j.ijpharm.2021.120933.
10.1016/j.ijpharm.2021.120933
- Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A.; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F.; Malaguti, Fabiana; et
al. "Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy". Journal of Experimental & Clinical
Cancer Research 40 1 (2021): http://dx.doi.org/10.1186/s13046-021-01993-9.
10.1186/s13046-021-01993-9
- Ana Filipa Fernandes da Cruz; Mariana Biscaia Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio;
Vera Moura; et al. "The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the
F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway". Cancers (2021): https://www.mdpi.com/2072-6694/13/12/3052.
10.3390/cancers13123052
- Rui Lopes; Kevin Shi; Nuno A. Fonseca; Adelina Gama; José S. Ramalho; Luís Almeida; Vera Moura; et al. "Modelling the impact
of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin".
Drug Delivery and Translational Research (2021): https://doi.org/10.1007/s13346-021-00972-z.
10.1007/s13346-021-00972-z
- Fonseca, Nuno A.; Gregório, Ana C.; Mendes, Vera M.; Lopes, Rui; Abreu, Teresa; Simões, Sérgio; Moreira, João Nuno. "GMP-grade
nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic
exposure". Nano Today 37 (2021): 101095. http://dx.doi.org/10.1016/j.nantod.2021.101095.
10.1016/j.nantod.2021.101095
- Cláudia Pina Costa; João Nuno Moreira; José Manuel Sousa Lobo; Ana Catarina Silva. "Intranasal delivery of nanostructured
lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies". Acta Pharmaceutica
Sinica B (2021): https://doi.org/10.1016/j.apsb.2021.02.012.
10.1016/j.apsb.2021.02.012
- Carvalho, Laura Sofia; Gonçalves, Nélio; Fonseca, Nuno André; Moreira, João Nuno. "Cancer Stem Cells and Nucleolin as Drivers
of Carcinogenesis". Pharmaceuticals 14 1 (2021): 60. http://dx.doi.org/10.3390/ph14010060.
10.3390/ph14010060
- Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana Catarina. "Application
of the Quality-by-Design (QbD) Approach to Improve the Nose-to-Brain Delivery of Diazepam-Loaded Nanostructured Lipid Carriers
(NLCs)". Proceedings 78 1 (2020): 40. http://dx.doi.org/10.3390/iecp2020-08658.
10.3390/iecp2020-08658
- Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C.. "Using the quality by design (QbD) approach to
optimize formulations of lipid nanoparticles and nanoemulsions: A review". Nanomedicine: Nanotechnology, Biology and Medicine
(2020): 102206. http://dx.doi.org/10.1016/j.nano.2020.102206.
No prelo • 10.1016/j.nano.2020.102206
- Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno (EF1B-FA3D-0787). "Current challenges and emerging
opportunities of CAR-T cell therapies". Journal of Controlled Release 319 (2020): 246-261. http://dx.doi.org/10.1016/j.jconrel.2019.12.047.
10.1016/j.jconrel.2019.12.047
- Romano, Sofia; Fonseca, Nuno; Simões, Sérgio; Gonçalves, João; Moreira, João Nuno. "Nucleolin-based targeting strategies for
cancer therapy: from targeted drug delivery to cytotoxic ligands". Drug Discovery Today 24 10 (2019): 1985-2001. http://dx.doi.org/10.1016/j.drudis.2019.06.018.
Publicado • 10.1016/j.drudis.2019.06.018
- Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C.. "Nose-to-brain delivery of lipid-based nanosystems
for epileptic seizures and anxiety crisis". Journal of Controlled Release 295 (2019): 187-200. http://dx.doi.org/10.1016/j.jconrel.2018.12.049.
Publicado • 10.1016/j.jconrel.2018.12.049
- Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro,
Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno. "Nucleolin is expressed in patient-derived samples and glioblastoma cells,
enabling improved intracellular drug delivery and cytotoxicity". Experimental Cell Research 370 1 (2018): 68-77. http://dx.doi.org/10.1016/j.yexcr.2018.06.005.
Publicado • 10.1016/j.yexcr.2018.06.005
- Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João. "Anticancer activity and antibody-dependent
cell-mediated cytotoxicity of novel anti-nucleolin antibodies". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-25816-8.
10.1038/s41598-018-25816-8
- Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno. "Meeting the needs
of breast cancer: A nucleolin's perspective". Critical Reviews in Oncology/Hematology 125 (2018): 89-101. http://dx.doi.org/10.1016/j.critrevonc.2018.03.008.
10.1016/j.critrevonc.2018.03.008
- Zupancic, Eva; Curato, Caterina; Kim, Jung-Seok; Yeini, Eilam; Porat, Ziv; Viana, Ana S.; Globerson-Levin, Anat; et al. "Nanoparticulate
vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer". Nanomedicine: Nanotechnology,
Biology and Medicine 14 3 (2018): 835-847. http://dx.doi.org/10.1016/j.nano.2017.12.011.
10.1016/j.nano.2017.12.011
- Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno. "Targeting Cancer Stem Cells and Non-Stem
Cancer Cells: The Potential of Lipid- Based Nanoparticles". Current Pharmaceutical Design 23 43 (2018): 6563-6572.
http://dx.doi.org/10.2174/1381612823666171115105252.
10.2174/1381612823666171115105252
- Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório;
et al. "Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer". Pathology & Oncology
Research 24 4 (2017): 701-716. http://dx.doi.org/10.1007/s12253-017-0307-2.
10.1007/s12253-017-0307-2
- Zupancic, Eva; Curato, Caterina; Paisana, Maria; Rodrigues, Catarina; Porat, Ziv; Viana, Ana S.; Moreira, João N.; et al.
"Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming". Journal of Controlled
Release 258 (2017): 182-195. http://dx.doi.org/10.1016/j.jconrel.2017.05.014.
10.1016/j.jconrel.2017.05.014
- Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "The cancer stem cell phenotype as a
determinant factor of the heterotypic nature of breast tumors". Critical Reviews in Oncology/Hematology 113 (2017):
111-121. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016.
10.1016/j.critrevonc.2017.03.016
- Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira,
João Nuno. "Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer
Murine Model". PLOS ONE 11 11 (2016): e0165817. http://dx.doi.org/10.1371/journal.pone.0165817.
10.1371/journal.pone.0165817
- Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et
al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological
phenotype". Biomaterials 82 (2016): 124-137. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021.
Publicado • 10.1016/j.biomaterials.2015.12.021
- Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et
al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief
6 (2016): 700-705. http://dx.doi.org/10.1016/j.dib.2016.01.017.
10.1016/j.dib.2016.01.017
- Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al. "Dual
release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome". RSC Advances 6 115 (2016): 114599-114612.
https://doi.org/10.1039/C6RA21623D.
10.1039/C6RA21623D
- J. Goncalves; L. Graça; Moreira, João Nuno; I. V. Figueiredo; F. Scappaticci; J. Eurico Fonseca; F. Magro; et al. "Development
of e-learning platform about biologic drugs with focus on monoclonal antibodies". International Journal of Clinical Pharmacy
38 2 (2016): 519-520.
Publicado
- Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João
Nuno. "Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted
intracellular delivery of synergistic drug combination". Biomaterials 69 (2015): 76-88. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007.
Publicado • 10.1016/j.biomaterials.2015.08.007
- Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena. "Translational
Peptide-associated Nanosystems: Promising Role as Cancer Vaccines". Current Topics in Medicinal Chemistry 16 3 (2015):
291-313. http://dx.doi.org/10.2174/1568026615666150701115508.
10.2174/1568026615666150701115508
- Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Antibacterial
activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin". Acta Biomaterialia 18 (2015):
196-205. http://dx.doi.org/10.1016/j.actbio.2015.02.018.
10.1016/j.actbio.2015.02.018
- Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Simultaneous active intracellular
delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination".
Journal of Controlled Release 196 (2014): 122-131. http://dx.doi.org/10.1016/j.jconrel.2014.09.024.
10.1016/j.jconrel.2014.09.024
- Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves,
Nuno M.. "Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering".
ACS Nano 8 8 (2014): 8082-8094. http://dx.doi.org/10.1021/nn5021049.
Publicado • 10.1021/nn5021049
- Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N.. "Bridging cancer biology
and the patients' needs with nanotechnology-based approaches". Cancer Treatment Reviews 40 5 (2014): 626-635. http://dx.doi.org/10.1016/j.ctrv.2014.02.002.
Publicado • 10.1016/j.ctrv.2014.02.002
- Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F.. "Development of a Novel Nanoparticle-based
Therapeutic Vaccine for Breast Cancer Immunotherapy". Procedia in Vaccinology 8 (2014): 62-67. http://dx.doi.org/10.1016/j.provac.2014.07.011.
Publicado • 10.1016/j.provac.2014.07.011
- Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves,
Nuno M.. "Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering".
Biomater. Sci. 2 9 (2014): 1195-1209. http://dx.doi.org/10.1039/c4bm00069b.
Publicado • 10.1039/c4bm00069b
- Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N.. "Challenging
the future of siRNA therapeutics against cancer: the crucial role of nanotechnology". Cellular and Molecular Life Sciences
71 8 (2013): 1417-1438. http://dx.doi.org/10.1007/s00018-013-1502-2.
Publicado • 10.1007/s00018-013-1502-2
- Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Impact of anti-PLK1
siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells". European Journal of Pharmaceutics
and Biopharmaceutics 85 3 (2013): 356-364. http://dx.doi.org/10.1016/j.ejpb.2013.04.007.
Publicado • 10.1016/j.ejpb.2013.04.007
- Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves,
Nuno M.; Moreira, João Nuno. "On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human
mesenchymal stem cells". Journal of Tissue Engineering and Regenerative Medicine 9 9 (2013): 1056-1066. http://dx.doi.org/10.1002/term.1817.
Publicado • 10.1002/term.1817
- Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões,
Sérgio; Moreira, João N. "Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform". Nanomedicine
8 9 (2013): 1397-1413. http://dx.doi.org/10.2217/nnm.12.174.
Publicado • 10.2217/nnm.12.174
- Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N;
Pereira de Almeida, Luís; Pedroso de Lima, Maria C. "Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery
to glioblastoma cells: a promising system for glioblastoma treatment". Molecular Therapy - Nucleic Acids 2 (2013):
e100. http://dx.doi.org/10.1038/mtna.2013.30.
Publicado • 10.1038/mtna.2013.30
- Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Impact of PLK-1 silencing on
endothelial cells and cancer cells of diverse histological origin". Current Gene Therapy 13 3 (2013): 189-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS.
10.2174/1566523211313030004
- Figueiredo, S.; Cutrin, J.C.; Rizzitelli, S.; De Luca, E.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.. "MRI
Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent". Molecular
Imaging and Biology 15 3 (2013): 307-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727777&partnerID=MN8TOARS.
10.1007/s11307-012-0603-x
- Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões,
Sérgio; Moreira, João N.. "Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment".
International Journal of Pharmaceutics 434 1-2 (2012): 9-19. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018.
Publicado • 10.1016/j.ijpharm.2012.05.018
- Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Lipid-Based
Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges". Accounts of Chemical Research 45 7 (2012):
1163-1171. http://dx.doi.org/10.1021/ar300048p.
Publicado • 10.1021/ar300048p
- Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Development, Characterization and In Vitro Evaluation
of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations". Journal of Nanoscience and Nanotechnology 12 3 (2012):
2891-2900. http://dx.doi.org/10.1166/jnn.2012.5703.
10.1166/jnn.2012.5703
- Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Selective Cytotoxicity
of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR". Journal of Medicinal
Chemistry 54 18 (2011): 6375-6393. http://dx.doi.org/10.1021/jm200803d.
10.1021/jm200803d
- Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E.. "[Visualization
of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]". Revista Portuguesa de Pneumologia (English
Edition) 17 5 (2011): 240. http://dx.doi.org/10.1016/j.rppnen.2011.09.002.
10.1016/j.rppnen.2011.09.002
- Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso;
Simões, Sérgio; Moreira, João N.. "Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor
microenvironment: impact on the treatment of breast cancer". Breast Cancer Research and Treatment 133 1 (2011): 61-73.
http://dx.doi.org/10.1007/s10549-011-1688-7.
Publicado • 10.1007/s10549-011-1688-7
- Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo. "Yeast cell
wall particles: a promising class of nature-inspired microcarriers for multimodal imaging". Chemical Communications
47 38 (2011): 10635. http://dx.doi.org/10.1039/c1cc14019a.
Publicado • 10.1039/c1cc14019a
- Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.. "Supramolecular protamine/Gd-loaded liposomes adducts
as relaxometric protease responsive probes". Bioorganic and Medicinal Chemistry 19 3 (2011): 1131-1135. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS.
10.1016/j.bmc.2010.07.057
- Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Liposomal imatinib-mitoxantrone combination: Formulation development
and therapeutic evaluation in an animal model of prostate cancer". The Prostate 71 1 (2010): 81-90. http://dx.doi.org/10.1002/pros.21224.
10.1002/pros.21224
- Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Sterols as Anticancer
Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis". Journal of Medicinal
Chemistry 53 21 (2010): 7632-7638. http://dx.doi.org/10.1021/jm1007769.
Publicado • 10.1021/jm1007769
- Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N.. "In vitro modulation of Bcl-2 levels in small
cell lung cancer cells: effects on cell viability". Brazilian Journal of Medical and Biological Research 43 10 (2010):
1001-1009. http://dx.doi.org/10.1590/s0100-879x2010007500099.
Publicado • 10.1590/s0100-879x2010007500099
- Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio. "Co-encapsulation of anti-BCR-ABL siRNA
and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment".
Biotechnology and Bioengineering 107 5 (2010): 884-893. http://dx.doi.org/10.1002/bit.22858.
Publicado • 10.1002/bit.22858
- Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Schedule treatment design and quantitative in vitro
evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy". Cancer Chemotherapy and Pharmacology
67 2 (2010): 275-284. http://dx.doi.org/10.1007/s00280-010-1315-z.
Publicado • 10.1007/s00280-010-1315-z
- Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N..
"Design of peptide-targeted liposomes containing nucleic acids". Biochimica et Biophysica Acta (BBA) - Biomembranes
1798 3 (2010): 433-441. http://dx.doi.org/10.1016/j.bbamem.2009.12.001.
Publicado • 10.1016/j.bbamem.2009.12.001
- Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio. "Transferrin Receptor-Targeted
Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment". Bioconjugate Chemistry
21 1 (2010): 157-168. http://dx.doi.org/10.1021/bc9004365.
Publicado • 10.1021/bc9004365
- Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P.. "Synthesis and structure-activity relationship
study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Bioorganic
and Medicinal Chemistry 18 12 (2010): 4385-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS.
10.1016/j.bmc.2010.04.085
- Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Efficient Chemoenzymatic
Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols". Journal of Medicinal Chemistry 52 13 (2009): 4007-4019.
http://dx.doi.org/10.1021/jm9003973.
Publicado • 10.1021/jm9003973
- Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso. "Targeted Lipoplexes for siRNA
Delivery". Methods in Enzymology (2009): 267-287. http://dx.doi.org/10.1016/s0076-6879(09)65014-x.
10.1016/s0076-6879(09)65014-x
- Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Ciprofloxacin sensitizes hormone-refractory prostate cancer cell
lines to doxorubicin and docetaxel treatment on a schedule-dependent manner". Cancer Chemotherapy and Pharmacology
64 3 (2008): 445-454. http://dx.doi.org/10.1007/s00280-008-0892-6.
Publicado • 10.1007/s00280-008-0892-6
- Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N.. "Simultaneous evaluation of viability
and Bcl-2 in small-cell lung cancer". Cytometry Part A 73A 12 (2008): 1165-1172. http://dx.doi.org/10.1002/cyto.a.20634.
Publicado • 10.1002/cyto.a.20634
- João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al. "Non-viral
lipid-based nanoparticles for cancer systemic gene silencing". Journal of Nanoscience and Nanotechnology 8 5 (2008):
2187-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS.
Publicado • 10.1166/jnn.2008.319
- Moreira, João Nuno; Santos, Adriana; Simões, Sérgio. "Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical
Reality". Reviews on Recent Clinical Trials 1 3 (2006): 217-235. http://dx.doi.org/10.2174/157488706778250050.
Publicado • 10.2174/157488706778250050
- FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S. "Targeting of sterically stabilised pH-sensitive liposomes
to human T-leukaemia cells". European Journal of Pharmaceutics and Biopharmaceutics 59 2 (2005): 359-366. http://dx.doi.org/10.1016/j.ejpb.2004.08.012.
Publicado • 10.1016/j.ejpb.2004.08.012
- Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima. "On the formulation of pH-sensitive liposomes with
long circulation times". Advanced Drug Delivery Reviews 56 7 (2004): 947-965. http://dx.doi.org/10.1016/j.addr.2003.10.038.
10.1016/j.addr.2003.10.038
- Moreira, J.N.; Gaspar, R.. "Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small
cell lung cancer". Brazilian Journal of Medical and Biological Research 37 8 (2004): 1185-1192. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS.
Publicado • 10.1590/s0100-879x2004000800008
- Moreira, J.N.; Simões, S.. "Technology evaluation: LErafAON, NeoPharm". Current Opinion in Molecular Therapeutics 5
5 (2003): 547-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS.
Publicado
- Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M..
"Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding
activity and cytotoxicity". Pharmaceutical Research 19 3 (2002): 265-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS.
Publicado • 10.1023/A:1014434732752
- Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Journal of Liposome Research
12 1-2 (2002): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS.
10.1081/LPR-120004771
- Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M.. "Targeting Stealth liposomes
in a murine model of human small cell lung cancer". Biochimica et Biophysica Acta (BBA) - Biomembranes 1515 2 (2001):
167-176. http://dx.doi.org/10.1016/s0005-2736(01)00411-4.
Publicado • 10.1016/s0005-2736(01)00411-4
- Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa
M.. "A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer".
Biochimica et Biophysica Acta - Biomembranes 1514 2 (2001): 303-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS.
Publicado • 10.1016/S0005-2736(01)00386-8
- Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L.. "Carboplatin liposomes coated with O-palmitoylpullulan:
In vitro characterization". International Journal of Pharmaceutics 147 2 (1997): 153-164. http://dx.doi.org/10.1016/s0378-5173(96)04808-9.
Publicado • 10.1016/s0378-5173(96)04808-9
- Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L..
"Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)".
Journal of Materials Science: Materials in Medicine 7 5 (1996): 301-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS.
Publicado • 10.1007/bf00058571
- Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A.. "Characterization of the in vitro dissolution of some commercial sustained
release theophylline dosage forms". Drug Development and Industrial Pharmacy 20 8 (1994): 1471-1483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS.
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Artigo em revista (magazine) |
- Mariana Biscaia Caleiras; Simões, Sérgio (0A12-4D47-DC3C); Moreira, João Nuno. "Lipid Nanoparticles as a tool to tackle de
patients needs: from small drugs to mRNA.", News Farma, 2021
- Moreira, João Nuno. "A Nanotecnologia e o desenvolvimento de novos medicamentos", Mundo Farmacêutico, 2011
- Ferreira, F.; Moreira, João Nuno; Prazeres, D. M.; Rocha, I.; Rodrigues, L.. "Bioteams: do Laboratório para o Mercado", Boletim
Biotecnologia - Sociedade Portuguesa de Biotecnologia, 2011
- Antunes, A.; Botelho, M. F.; Gomes, C. M.; Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.. "Desenvolvimento
de lipossomas com afinidade para áreas miocárdicas isquémicas", Ser Saúde, 2007
- Moreira, João Nuno. "Os lipossomas na terapia antitumoral: de esferas fosfolipídicas à aplicação clínica", Mundo Médico, 2000
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Capítulo de livro |
- Abreu, Teresa R.; Biscaia, Mariana; Gonçalves, Nélio; Fonseca, Nuno A.; Moreira, João Nuno. "In Vitro and In Vivo Tumor Models
for the Evaluation of Anticancer Nanoparticles". In Advances in Experimental Medicine and Biology, 271-299. Springer
International Publishing, 2021.
10.1007/978-3-030-58174-9_12
- Ribeiro, Rita; Abreu, Teresa Raquel; Silva, Ana Catarina; Gonçalves, João; Moreira, João Nuno. "Insights on the Formulation
of Recombinant Proteins". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology,
23-54. Springer International Publishing, 2020.
10.1007/10_2019_119
- Silva, Ana Catarina; Costa, Cládia Pina; Almeida, Hugo; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hormones, Blood Products,
and Therapeutic Enzymes". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology.,
115-153. Springer International Publishing, 2020.
Publicado • 10.1007/10_2019_111
- Abreu, T. R.; Biscaia, M.; Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "In vitro and in vivo tumor models for the
evaluation of anticancer nanoparticles". In Biomedicine for Cancer Therapy, editado por Hélder Santos; Flavia Fontana.
Springer Nature, 2020.
No prelo
- Silva, Ana Catarina; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hematopoietic Growth Factors". In Encyclopedia of Molecular
Pharmacology, 1-5. Springer International Publishing, 2020.
10.1007/978-3-030-21573-6_72-1
- Cruz, Ana Filipa; Fonseca, Nuno A.; Gregório, Ana C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Moving Liposome Technology
from the Bench to the Oncological Patient: Towards Performance-by-Design". In Particles and Nanoparticles in Pharmaceutical
Products, editado por Merkus H.; Meesters G.; Oostra W., 171-211. Springer International Publishing, 2018.
Publicado • 10.1007/978-3-319-94174-5_4
- Fonseca, Nuno A.; Lopes, Rui M.; Cruz, Ana F.; Gregório, Ana C.; Valério-Fernandes, Ângela; Moura, Vera; Simões, Sérgio; Moreira,
João Nuno. "Lipid-Based Nanosystems for the Delivery of siRNA: Challenges and Trends". In Handbook of Nanomaterials for
Cancer Theranostics, editado por João Conde, 495-515. Elsevier, 2018.
Publicado • 10.1016/b978-0-12-813339-2.00016-5
- Lopes, R.M.; Fonseca, N.A.; Cruz, A.F.; Gregório, A.C.; Valério-Fernandes, Â.; Moura, V.; Simões, S.; Moreira, J.N.. "Advances
on nucleic acid delivery with nonviral vectors". In Bioinspired Materials for Medical Applications, editado por Lígia
Rodrigues, 403-426. Elsevier, 2017.
Publicado • 10.1016/b978-0-08-100741-9.00014-0
- Gomes-da-Silva, L.C.; Sérgio Simões; Moreira, João Nuno. "The use of liposomes for the systemic delivery of RNAi therapeutics
aiming at cancer treatment". In Liposomal delivery systems - Advances and challenges, editado por Ryan De Vooght-Johnson,
105-119. Future Science, 2016.
Publicado • 10.4155/fseb2013.14.182
- Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Quimioterapia combinada no tratamento do cancro: princípios e estratégias
nanotecnológicas de entrega de fármacos". In Biomateriais aplicados ao desenvolvimento de sistemas terapêuticos avançados,
editado por H.C. De Sousa; M.E.M. Braga; A. Sosnik, 675-700. Imprensa da Universidade de Coimbra, 2015.
10.14195/978-989-26-0881-5_17
- Catarina, Ana; João Nuno Moreira; Simoes, Sergio. "Combination Chemotherapy in Cancer: Principles, Evaluation and Drug Delivery
Strategies". In Current Cancer Treatment - Novel Beyond Conventional Approaches, editado por Öner Özdemir. InTech,
2011.
Publicado • 10.5772/22656
- Moreira, João Nuno. "Moura V, Gomes da Silva LC, Fonseca NA, Pedroso de Lima MC, Simões S, Moreira JN, Emerging targets and
novel nanotechnology-based strategies: changing the treatment paradigm in oncology.". In Brain Cancer, Tumor Targeting
and Cervical Cancer, Elena K. Salvatti (Ed.), Nova Science Publishers (2011). ISBN: 978-1-61122-738-3., 39-74. 2011.
Publicado
- Moreira, João Nuno; Santos, A.; Bimbo, L.M.; Gomes da Silva, L. C.; Pedroso de Lima, M. C.; Simões, S.. "Gene silencing therapy
in small cell lung cancer – which agents, targets, and delivery systems?". In Small-Cell Carcinomas: Causes, Diagnosis,
and Treatment, editado por Jonathon G. Maldonado; Mikayla K. Cervantes, 1-51. Nova Science Publishers, 2009.
Publicado
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Edição de livro |
- Moreira, João Nuno. Current Applications of Pharmaceutical Biotechnology. Springer International Publishing. 2020.
Publicado • 10.1007/978-3-030-40464-2 • Editor
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Poster em conferência |
- Martins, Ângela; Ivasiv, Viktoriya; Bertão, Ana; Nunes, Nélson; Aguiar, C. Almeida; Fonseca, A. M.; Moreira, João Nuno; et
al. "P12.010 Metal ion-hierarchical zeolites as Fenton-like catalysts for health applications". Trabalho apresentado em 20th
International Zeolite Conference; Valencia, Spain, 2022.
- Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino;
Silva, Ana Paula; et al. "Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a
Potential Route for Brain Drug Delivery". Trabalho apresentado em 5th ASPIC International Congress, 2022.
- Cláudia Pina Costa; Nizic Nodilo; L. Zadravc; D. Kalogiera; Moreira, João Nuno; José Manuel Sousa Lobo; A. Hafner; Ana Catarina
Silva. "P20: Evaluation of the deposition of an in situ hydrogel containing diazepam loaded nanostructured lipid carriers
(NLC) in a 3D nasal cavity model.". Trabalho apresentado em 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical
Technology, 2022.
- Costa, CP; Cunha, S.; Moreira, João Nuno (EF1B-FA3D-0787); Sousa Loubo, JM; Silva, AC. "Optimization of diazepam-loaded nanostructured
lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach, Abstract nr 46". Trabalho apresentado
em Virtual Vancouver Nanomedicine Day, 2020.
- C.P. Costa; S. Cunha; Moreira, João Nuno; M.H. Amaral; J.M. Sousa Lobo; A.C. Silva. "Optimization of lipid nanoparticles formulation
for nose-to-brain delivery using the quality by design (QbD) approach". Trabalho apresentado em 12th World Meeting on Pharmaceutics,
Biopharmaceutics and Pharmaceutical Technology, 2020.
- Ribeiro, R.; Moreira, João Nuno; Gonçalves, J.. "Increasing the affinity of anti-nucleolin antibodies against triple negative
breast cancer using a phage display approach". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences,
2019.
- Abreu, Teresa; Fonseca, Nuno A.; Moreira, João Nuno. "Specific recognition of the onco-target nucleolin by the tumor homing
F3 peptide". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
- Biscaia-Caleiras, M.; Fonseca, Nuno A.; Cruz, A.F.; Gonçalves, N.; Moreira, João Nuno. "Targeted delivery of doxorubicin and
C6-ceramide combinations to non-small cell lung cancer cells - Key factors for C6-ceramide's cytotoxicity". Trabalho apresentado
em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
- Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "Synergistic cytotoxicity of targeted
liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cells is supported by the downregulation of
the PI3K/Akt pathway". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences, 2019.
- Costa, C. P.; Cunha, S.; Moreira, João Nuno; Amaral, N. H.; Sousa Lobo, J. M.. "Hydrogel formulations containing nanostructured
lipid carriers (NLC) and nanoemulsions (NE) for intranasal delivery of carbamazepine". Trabalho apresentado em 1st Annual
Meeting in Pharmaceutical Sciences, 2019.
- Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "The Potential Of Liposomal C6-ceramide/doxorubicin
Targeted To Nucleolin To Decrease Triple-negative Breast Cancer Stem Cell Population, Relative To A Standard Of Treatment".
Trabalho apresentado em 2019 Controlled Release Society Annual Meeting, 2019.
- Costa, C. P.; Cunha, S.; Silva, A.C.; Amaral, M. H.; Sousa Lobo, J. M.; Moreira, João Nuno. "Development Of A Semi-solid Formulation
For The Intranasal Delivery Of Carbamazepine By Means Of Lipid-based Nanosystems". Trabalho apresentado em 2019 Controlled
Release Society Annual Meeting, 2019.
- Fonseca, Nuno A.; Gregório, A.C.; Mendes, V.; Lopes, R.; Manadas, B.; Lacerda, M.; Figueiredo, P.; et al. "Tumor intracellular
bioavailability of doxorubicin determines therapeutic efficacy of nanoparticle targeted to nucleolin". Trabalho apresentado
em 3rd ASPIC International Congress, 2018.
- C. Pechincha; Fonseca, Nuno A.; J. S. Ramalho; Moreira, João Nuno. "Nucleolin as a functional driver of breast cancer cells
and a target for anti-cancer therapies". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery,
2018.
- Cruz, A. F.; Fonseca, Nuno A.; Moura, V.; Simões, S.; Moreira, João Nuno. "Cytotoxicity of targeted liposomal C6-ceramide
and doxorubicin against nucleolin-overexpressing cancer cell lines is supported by the downregulation of the Akt pathway and
is more effective than conventional drug combinations". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled
Drug Delivery, 2018.
- Romano, N.; Oliveira, A. R.; Moura, V.; Simões, S.; Moreira, João Nuno. "Engineering novel anti-nucleolin antibody fragments
with antibody-dependent cell-mediated cytotoxicity". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled
Drug Delivery, 2018.
- Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "Cell surface/cytoplasmic relative levels of nucleolin: a key feature
for successful anticancer nanotherapies targeting nucleolin". Trabalho apresentado em XII Spanish-Portuguese Conference
on Controlled Drug Delivery, 2018.
- Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Raghu Kalluri; Moreira, João
Nuno. "Epigenetic unbalance may increase lung incidence in patients affected by idiopatic pulomonary fibrosis". Trabalho apresentado
em ERS Conference, 2017.
- Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Moreira, João Nuno. "The presence
of activated fibroblasts can explain the increase incidence of lung cancer after pulmonary fibrosis". Trabalho apresentado
em ASPIC Conference, 2016.
- Balça-Silva, Joana; Moreira, João Nuno; do Carmo, Anália; Moura Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela. "Specific cellular
association of liposomes by stem-like cells improves therapeutic efficacy in glioblastoma". Trabalho apresentado em Annual
Meeting of Neuroscience, 2016.
- Mariangela Natale; Sylvia Vong; Michael Zeisberg; Lina Carvalho; Björn Tampe; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri.
"Functional role of alfa smooth muscle actin positive cells in the pathogenesis of lung cancer". Trabalho apresentado em University
of Germany, 2015.
- Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri.
"Genome wide analysis of human lung cancer associated fibroblasts (CAFs): The functional contribution of alfa smooth muscle
actin positive myofibroblasts in the initiation of lung cancer". Trabalho apresentado em MD Anderson Cancer Center, GAP
Conference, 2015.
- Moreira, João Nuno; Gregório, A.C.; Fonseca, Nuno A.; Moura, V.; Domingues G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias
S.. "Targeting cell surface nucleolin in metastatic breast cancer". Trabalho apresentado em 1st ASPIC International Congress
of the Portuguese Association for Cancer Research, 2014.
- Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri.
"Cancer Associated Fibroblasts in the microenvironmet of lung cancer". Trabalho apresentado em Medimmune, 2014.
- Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina;
Simões, Sérgio; Moreira, João Nuno. "Nucleolin in lung cancer – an emerging target to overcome stroma-mediated anti-angiogenic
resistance". Trabalho apresentado em 1st ASPIC International Congress, 2014.
- Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Santos-Rosa, Manuel; Moura, Vera; Ramalho-Santos,
João; Simões, Sérgio; Moreira, João Nuno. "Nucleolin-mediated targeting of breast cancer cell subpopulations with different
stem-like phenotype". Trabalho apresentado em 1st ASPIC International Congress, 2014.
- Valério-Fernandes, Â.; Fonseca, N.A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; et al. "Nucleolin-mediating
targeting of the tumor microenvironment in bevacizumab-resistant Lung Cancer". Trabalho apresentado em Xth Spanish-Portuguese
Conference on Controlled Drug Delivery: Drug Delivery Systems from Lab to Clinic – New Trends and Opportunities, 2013.
- Fonseca, Nuno A.; Simões, Sérgio; Moreira, João Nuno. "Rational design of synergistic drug combinations against breast cancer".
Trabalho apresentado em EMBO Young Scientists’ Forum, 2013.
- Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.; Moreira, João
Nuno. "Assessing the potential of nucleolin-targeted strategies against Lung Cancer resistant to anti-VEGF therapies". Trabalho
apresentado em XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting -TRANSLATIONAL RESEARCH IN CANCER, 2013.
- Monteiro N.; Martins A.; Pires R.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release of Bioactive
Agent from Liposomes Immobilized on Electrospun Nanofibers Targeting Tissue Engineering Applications". Trabalho apresentado
em Annual Meeting of the Society For Biomaterials, 2013.
- Monteiro N.; Martins A.; Ribeiro D.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "On the Use
of Dexamethasone Loaded Liposomes to Induce the Osteogenic Differentiation of Human Mesenchymal Stem Cells". Trabalho apresentado
em Annual Meeting of the Society For Biomaterials, 2013, 2013.
- Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Moreira, João Nuno. "Targeted
drug delivery to the tumor microenvronment in lung cancer". Trabalho apresentado em X Annual Meeting of the Center for
Neuroscience and Cell Biology, 2012.
- Carvalho, J. F. S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Exploring the relevance
of the oxysteril's C-6 and C-7 positions for cytotoxicity". Trabalho apresentado em 3rd Portuguese meeting on Medicinal
Chemistry, 2012.
- Monteiro N. S.; Martins A.; Ribeiro D.; Pires R. A.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release
of growth factors from liposomes immobilized on electrospun nanofibers targeting tissue engineering applications". Trabalho
apresentado em 3rd MIT-Portugal Program Conference, 2012.
- Figueiredo, S.; Rizzitelli, S.; Aime, S.; Geraldes, C.F.G.C.; Moreira, João Nuno. "Nature-inspired particles as carriers for
multimodal molecular imaging applications". Trabalho apresentado em IEEE 2nd Portuguese Meeting In Bioengineering,
2012.
- Carvalho, J.F.S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Oxysterol as selective
cytotoxic and chemosensitizer agents. Synthesis and cell proliferation studies". Trabalho apresentado em . III Congress
of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
- Moura, V.; Figueiredo, P.; Corvo, M. L.; Cruz M. E.; Soares, R.; Pedroso de Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted
and triggered to the tumor microenviroment: impact on the treatment of solid tumors". Trabalho apresentado em Congress
of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
- Fonseca A. R.; Alves, R.; Gonçalves, A. C.; Silva, L.; Alves, A.; Moreira, João Nuno; Sarmento-Ribeiro, A. B.. "RNAi induced
down-regulation of FLT3 expression in Acute Myeloid Leukemia (AML) and increase sensitivity to the Proteasome Inhibitor, MG262".
Trabalho apresentado em THE Young European Scientist Meeting (YES Meeting), 2011.
- Figueiredo, S.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.; Terreno, E.. "Gd-loaded yeast cell wall particles as
an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em
Metal-Based Systems for Molecular Imaging Applications - Cost D38 Final Meeting, 2011.
- Figueiredo, S.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.; Moreira, João Nuno. "Gd-loaded yeast cell wall particles as an
innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em World
Molecular Imaging Congress, 2011.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Gd-loaded Yeast cell wall particles: an innovative
micron-sized platform for labeling and tracking immune cells by multimodal imaging". Trabalho apresentado em 36th FEBS
Congress, 2011.
- Pinto, A.C.; Moreira, João Nuno; Simões, S.. "Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic
evaluation in an animal model of prostate cancer". Trabalho apresentado em I Symposium on Nanoscience and Biomedical Nanotechnology,
2011.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Yeast cell wall particles as highly sensitive
MRI contrast agents". Trabalho apresentado em Metal-Based Systems for Molecular Imaging Applications - Joint Working Groups
2 and 6 meeting, 2011.
- Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Riva, S; Sá e Melo, M. L.. "Synthesis of a library of glycosyl
and acyl glycosyl oxysterols, cytotoxic profile and SAR". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry
- Portuguese Chemical Society (SPQ), 2010.
- Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simoes, S.; Sá e Melo M. L.. "Synthesis and cytotoxic evaluation of
trihydroxysteroids". Trabalho apresentado em XXI International Symposium on Medicinal Chemistry, 2010.
- Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Gd(III)-loaded liposomes
as enzyme responsive MRI probes". Trabalho apresentado em 2010 World Molecular Imaging Congress, 2010.
- Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M. L.; Cruz, M. E.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno.
"Targeting non-viral vectors to tumor cells and the tumor micronvironment". Trabalho apresentado em 16th International
Charles Heidelberger Symposium on Cancer Research, 2010.
10.1186/1753-6561-4-s2-o26
- Gomes da Silva, L. C.; Ramalho, J.S.; De Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Targeted Gene Silencing for Cancer
Treatment". Trabalho apresentado em The 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
10.1186/1753-6561-4-S2-P45
- Figueiredo, S.; Geraldes, C. F. G. C.; Moreira, João Nuno; Aime, S.. "MRI intelligent contrast agents as Enzyme Responsive
Nanosystems". Trabalho apresentado em 5th European Molecular Imaging Meeting, 2010.
- Gomes-da-Silva, L.C.; Bimbo, L.; Santos, A.; Ramalho, J. S.; de Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Ligand-mediated
targeted nanocarriers containing siRNA for cancer treatment". Trabalho apresentado em Keystone Symposia on Molecular and
Cell Biology: New Paradigms in Cancer Therapeutics, 2010.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive
relaxometric agents". Trabalho apresentado em 8th Inorganic Chemistry Conference, 2009.
- Carvalho, J.F.S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.; Carvalho, J. F. S.; Cruz Silva, M.M.. "Cytotoxic
epoxysterols: chemoenzymatic synthesis, biological evaluation and SAR". Trabalho apresentado em Frontiers in Medicinal
Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, 2009.
- Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "SMART MRI contrast agents:
enzyme responsive Nanosystems". Trabalho apresentado em 2009 World Molecular Imaging Congress, 2009.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.. "Paramagnetic liposomes as enzyme-responsive relaxometric
agents". Trabalho apresentado em 7th International Conference on f-Elements, 2009.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive
relaxometric agents". Trabalho apresentado em The 6th Conference on Field Cycling NMR Relaxometry, 2009.
- Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "MRI intelligent contrast agents: enzyme
responsive nanosystems". Trabalho apresentado em Meditrans Second Annual Meeting, 2009.
- Firmino, F.; Mendonça, L.S.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Delivery of asODNs to chronic myeloid
leukaemia by transferrin receptor targeted liposomes". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter
of the Controlled Release Society, 2008.
- Carvalheiro, M.; Moreira, João Nuno; Simões, S.; Cruz, M.E.M.. "Targeted delivery of c-myc antisense oligodeoxynucleotide
to SCLC mediated by novel lipidc vesicles". Trabalho apresentado em First Internal Meeting of iMed.UL, 2008.
- Pinto, A.C.; Ângelo, S.; Moreira, João Nuno; Simões, S.. "Individual or co-encapsulated liposomal Imatinib-mitoxantrone combination
for hormone-refractory prostate cancer therapy". Trabalho apresentado em 7th Congress of the Portuguese-Spanish Chapter
of the Controlled Release Society, 2008.
- Santos, A.; Pereira, J.P.; Sarmento-Ribeiro, A.B.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Targeted therapeutics
in SCLC – BCL2 revisited". Trabalho apresentado em Annual Meeting of the Center for Neuroscience and Cell Biology,
2007.
- Colla, M.; Moreira, João Nuno; Simões, S.. "Targeted delivery of c-Myc antisense oligodeoxynucleotide mediated by novel lipidic
vesicles". Trabalho apresentado em 1st European Science Foundation Summer School in Nanomedicine, 2007.
- Fonseca, C.; Mendonça, L.; Moreira, João Nuno; Cabrita, A.; Paiva, A.; Lopes, M. T.; Pedroso de Lima, M.C.; Simões, S.. "Novel
nanobiotechnology-based approaches for gene silencing: in vitro and in vivo evaluation for the treatment of human acute lymphoblastic
leukemia". Trabalho apresentado em Encontro da Associação Nacional de Farmácias, 2007.
- Pedroso de Lima, M. C.; Moura, V.; Simões, S.; Moreira, João Nuno. "Targeting stealth liposomes to human breast cancer cells
with a vasculature-homing peptide". Trabalho apresentado em Annual Meeting of the Center for Neuroscience and Cell Biology,
2006.
- Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted downregulation of the
BCL2 oncogene: a promising therapeutic strategy against small cell lung cancer". Trabalho apresentado em 7th Congress of
the Portuguese-Spanish Chapter of the Controlled Release Society, 2006.
- Carvalho, J. F. S.; Silva, M.M.C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Oxysterols as potential
anticancer agents. Synthesis and biological evaluation". Trabalho apresentado em Medicinal Chemistry in the 21st Century,
2006.
- Colla, M.; Moreira, João Nuno; Simões, S.; Cruz, M. E.. "Antagonist G targeted stabilized antisense-lipid particles (SALP-G):
a novel vector for delivery of antisense oligonucleotides to small cell lung cancer". Trabalho apresentado em 7th Congress
of the Portuguese-Spanish Chapter of the Controlled Release, 2006.
- Moreira, João Nuno; Pinto, A. C.; Simões, S.. "Ciprofloxacin and imatinib sensitize hormone-refractory prostate cancer cells
to conventional cytotoxic agents in a schedule-dependent manner". Trabalho apresentado em ACR Special Conference in Cancer
Research - Innovations in prostate cancer research, 2006.
- Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Antisense oligonucleotide-containing
liposomes targeted to growth fator receptors in small cell lung cancer". Trabalho apresentado em International Liposome
Society 2005 – Annual Meeting – Liposome Advances: Progress in Drug and Vaccine Delivery, 2005.
- Santos, A.; Zangemeister-Wittke, U.; Pedroso de Lima, M. C.; Simões, S.; Moreira, João Nuno. "Antagonist G peptide mediated
uptake of liposomes containing bcl-2 antisense oligonucleotides in small cell lung cancer cells". Trabalho apresentado em
Joint Annual Meeting of Graduate Programmes in Biosciences, 2005.
- Santos, A.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Novel targeted non-viral lipid-based vector for the treatment
of human small cell lung cancer: intracellular delivery of antisense oligonucleotides". Trabalho apresentado em 2nd Congress
of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled
Release Society, 2005.
- Carvalho, J.F.S.; Cruz Silva, M. M. C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Cytotoxic activity
of a library of synthetic sterols". Trabalho apresentado em 2nd Congress of the Portuguese Society of Pharmaceutical Sciences
and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
- Fonseca, C.; Moreira, João Nuno; de Lima, M.C.P.; Simões, S.. "Targeted delivery and pH-triggered release of antisense oligonucleotides
mediated by novel liposome formulations". Trabalho apresentado em 2nd Congress of the Portuguese Society of Pharmaceutical
Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
- Santos, A.; Simões, S.; Pedroso De Lima, M.C.; Moreira, João Nuno. "Targeted antisense therapy: a novel approach for the treatment
of small cell lung cancer". Trabalho apresentado em Joint Annual Meeting of Graduate Programmes in Biosciences, 2004.
- Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.;
Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Trabalho apresentado em IV Congresso
de Investigação em Medicina, 2004.
- Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Efficient intracellular delivery of antisense
oligonucleotides to human T-leukemia cells mediated by targeted sterically stabilized pH-sensitive liposomes". Trabalho apresentado
em 12th Annual Congress of the European Society of Gene Therapy, 2004.
- Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.;
Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Trabalho apresentado em 9th Annual
Meeting of the American Society of Nuclear Cardiology, 2004.
- Carvalho, J. F. S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Antitumor activity of a
library of synthetic sterols". Trabalho apresentado em XVIIth International Symposium on Medicinal Chemistry, 2004.
- Cruz Silva, M.M.; Carvalho, J.F.S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Synthesis
of polyhydroxysteroids and cytotoxic evaluation on HeLa cells". Trabalho apresentado em 19th National Meeting of the Portuguese
Society of Chemistry, 2004.
- Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Novel formulations of targeted pH-sensitive
liposomes bearing poly(ethylene glycol) as carriers for antisense oligonucleotides". Trabalho apresentado em 5th International
Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, 2003.
- Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.;
Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium – Preliminary results". Trabalho apresentado
em Annual Congress of European Association of Nuclear Medicine, 2003.
- Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Gonçalves, L.; Providência,
L. A.. "Desenvolvimento de lipossomas com afinidade para as áreas miocárdicas isquémicas". Trabalho apresentado em IX Congresso
Nacional de Medicina Nuclear, 2002.
- Fonseca, C.; Moreira, João Nuno; De Lima, M.C.P.; Simões, S.. "Novel formulations of targeted pH-sensitive liposomes bearing
poly)(ethylene glycol". Trabalho apresentado em V Spanish-Portuguese Conference on Controlled Drug Delivery, 2002.
- Moreira, João Nuno; Gaspar, R.; Allen, T.M.. "In vivo targeting of Stealth liposomes against human small cell lung cancer".
Trabalho apresentado em 8th Liposome Research Days Conference, 2002.
- Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Trabalho apresentado em 5th
International Conference on Liposome Advances: Progress in Drug and Vaccine, 2001.
- Fonseca, C.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Development of novel formulations of targeted sterically
stabilized pH-sensitive liposomes". Trabalho apresentado em 5th International Conference on Liposome Advances: Progress
in Drug and Vaccine Delivery, 2001.
- Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Post-insertion of peptide ligands into pre-formed stealth® liposomes with retention
of binding activity and cytotoxicity". Trabalho apresentado em 27th Meeting of the Federation of European Biochemical Societies,
2001.
- Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Imobilização à superfície de lipossomas de moléculas terapeuticamente activas:
aumento da sua afinidade para receptores celulares específicos". Trabalho apresentado em Segundas Jornadas da Sociedade
Portuguesa de Ciências Farmacêuticas, 2001.
- Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Lipossomas no transporte específico de doxorrubicina em terapia anti-tumoral".
Trabalho apresentado em VII National Symposium of the Portuguese Association of Hospitalar Pharmacists, 2000.
- Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "Pharmacokinetic properties and biodistribution of hexapeptide-targeted
Stealth® liposomes". Trabalho apresentado em IV Spanish-Portuguese Conference Controlled Drug Delivery, 2000.
- Moreira, João Nuno; Kirchmeier, M.; Gaspar, R.; Allen, T.M.. "Intracellular trafficking of hexapeptide-targeted Stealth liposomal
doxorubicin in a classical small cell lung cancer cell line". Trabalho apresentado em 7th Liposome Research Days Conference,
2000.
- Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "In vitro targeting of poly(ethylene glycol)-grafted liposomes
by hexapeptide to a classical small cell lung cancer cell line". Trabalho apresentado em 26th International Symposium on
Controlled Release of Bioactive Materials, 1999.
- Botelho, M. F.; Pedroso de Lima, J. J.; Dormehl, I. C.; Moreira, João Nuno; Santos, A. C.; Gomes, C. M.; Baganha, M. F.. "Visualização
de drenagem linfática através da inalação de lipossomas marcados". Trabalho apresentado em Congresso de Pneumologia,
1998.
- Botelho, M. F.; Moreira, João Nuno; Santos, A. C.; Gomes, C.; Gaspar, R.; Pedroso de Lima, J. J.. "Visualização linfática
por simulação da biodistribuição de bacilos com radiolipossomas". Trabalho apresentado em III Congress of the Controlled
Release Society, Spanish-Portuguese Local Chapter (SPLC-CRS), 1998.
- Gaspar, R.; Simões, S.; Moreira, João Nuno; Pereira de Almeida, L.; Alfar, S. C. F.; Gameiro, S.. "Drug targeting strategies
with colloidal carriers: an integrated approach for therapeutic innovation". Trabalho apresentado em 1st Meeting on Opportunities
for Pharmaceutical R&D in Portugal, 1998.
- Moreira, João Nuno; Hansen, C. B.; Allen, T.M.; Gaspar, R.. "Carboplatin encapsulation in sterically stabilized liposomes".
Trabalho apresentado em 12th Annual Meeting of Groupe Tematique de Recherche sur les Vecteures, 1997.
- Moreira, João Nuno; Almeida, L.M.; Madeira, V.M.C.; Costa, M.L.. "In vitro characterization of O-palmitoylpullulan coated
large unilamellar liposomes containing carboplatin". Trabalho apresentado em 1st Spanish-Portuguese Conference on Controlled
Drug Delivery, 1995.
- Moreira, João Nuno; Almeida, L.M.; Geraldes, C.F.; Costa, M. L.. "Improvement of in vitro stability of liposomes by coating
with a modified polysaccharide (O-palmitoylpullulan)". Trabalho apresentado em 12th European Conference on Biomaterials,
1995.
- Veiga, F.; Simões, S.; Moreira, João Nuno; Sousa, A.. "Evaluation of the in vitro dissolution of some commercial sustained
release theophylline dosage forms". Trabalho apresentado em 11th Conference on Pharmaceutical Technology, 1992.
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Prefácio / Posfácio |
- Ana Catarina Silva; Moreira, João Nuno; Sousa Lobo, José Manuel; Hugo Almeida. "Preface: Current Applications of Pharmaceutical
Biotechnology". Prefácio para Current Applications of Pharmaceutical Biotechnology, editado por Ana Catarina Silva;
Moreira, João Nuno; Sousa Lobo, José Manuel; Almeida, Hugo. Springer International Publishing. 2020.
Publicado
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Resumo em conferência |
- Abreu, TA; Godinho-Santos, A; Moreira, JN; Gonçalves, J. "P06.02 Anti-nucleolin CAR (chimeric antigen receptor)-T cell targeting
triple-negative breast cancer – critical parameters in CAR-T cells generation". Trabalho apresentado em 9th Immunotherapy
of Cancer Conference, Munich, 2022.
Publicado • 10.1136/jitc-2022-itoc9.42
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Tese / Dissertação |
- Moreira, João Nuno. "Targeting of liposomes to human small cell lung cancer". Doutoramento, Universidade de Coimbra Faculdade
de Farmácia, 2001.
- Moreira, João Nuno. "Characterization of carboplatin-containing liposomes coated with O-palmitoylpullulan". Mestrado, Universidade
de Coimbra Faculdade de Ciencias e Tecnologia, 1994.
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