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Identification

Personal identification

Full name
Gustavo Tiscornia

Citation names

  • Tiscornia, Gustavo

Author identifiers

Ciência ID
7818-59E3-E4EE
ORCID iD
0000-0002-1841-5330

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2001
Concluded
 PhD in Genetics (Doutoramento)
University of Wisconsin-Madison, United States
"Identification and Analysis of RNA Binding Proteins interacting with the Myotonic Dystrophy Protein Kinase 3’ untranslated region mRNA" (THESIS/DISSERTATION)
 Awarded
1989
Concluded
 Ciencias Biologicas (Licenciatura)
Universidad de Buenos Aires, Argentina
"Isolation of PHB- mutants in Bacillus megaterium" (THESIS/DISSERTATION)
 7.8/10
Affiliation

Science

Category
Host institution 		Employer
2016/04/01 - Current Coordinating Researcher (Research) Clínica Eugin, Spain
R&D Department, Clinica Eugin, Spain
2011/09/01 - Current Principal Investigator (Research) Universidade do Algarve, Portugal
1990/08/01 - 1991/12/31 Research Assistant (Research) Foundation for Applied Biological Science, Argentina

Teaching in Higher Education

Category
Host institution 		Employer
2011/09/01 - 2016/03/31 Assistant Professor (University Teacher) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Others

Category
Host institution 		Employer
2007/04/01 - 2011/08/26 Investigador Ramon y Cajal Centre de Medicina Regenerativa de Barcelona, Spain
2001/12/03 - 2006/08/31 Postdoctoral Researcher Salk Institute for Biological Studies, United States
1995/09/18 - 2001/08/16 PhD Candidate University of Wisconsin-Madison, United States
1992/02/03 - 1995/07/31 Instructor of General Biology St. George's College North, Argentina
Projects

Grant

Designation Funders
2020/01 - Current SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord.
MC-39-2019
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Santa Casa da Misericórdia de Lisboa
Ongoing
2016/04/01 - 2020/10/31 Regeneration in the African Spiny Mouse.
PTDC/BIA-ANM/0697/2014
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2017/12/31 Integrative studies on the role of Ccbe1 in cardiogenesis: from the embryo to scalable multipronged generation of hESC-derived myocardial cells for heart tissue repair
HMSP-ICT/0039/2013
Invited Scientist Fellow
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Concluded
2012/01/01 - 2016/12/31 In Vitro Derivation of Beta Cells by Ectopic Expression of Pancreatic Transcription Factors
FP7-PEOPLE-2011-CIG (# FP7-304225
Integration into Research Grant Fellow
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Concluded
2009/01/01 - 2012/12/31 Creación de una plataforma nacional para la derivación y manipulación de células iPS en condiciones GMP con fines terapéuticos
PLE2009-0164
Researcher
Centre de Medicina Regenerativa de Barcelona, Spain
Concluded
2006/01/01 - 2012/12/31 Red de Terapia Celular (TerCel)
RD06/0010/0016
Researcher
Centre de Medicina Regenerativa de Barcelona, Spain

Contract

Designation Funders
2020/10/01 - 2024/09/30 Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration (SKINTERM)
955722
Principal investigator
Ongoing
2013/01/01 - 2015/12/31 Genzyme Young Investigator Award: Development of an iPSc model for Gaucher’s Disease Type II.
Genzyme Young Investigator Award
Principal investigator
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Concluded
2004/01/01 - 2005/12/31 Lentiviral Delivery of siRNA against huntingtin
Hereditary Disease Foundation
Post-doc Fellow
Salk Institute for Biological Studies, United States
Concluded
Outputs

Publications

Book chapter
  1. Tiscornia, Gustavo; Lorenzo Vivas, E.; Izpisua Belmonte, J.C.. "MicroRNA regulation of Stem Cell fate and Reprogramming". In MicroRNAs in Medicine, 27-40. Hoboken, New Jersey, United States: John Wiley & sons, 2013.
    Published
  2. Singer, O.; Tiscornia, Gustavo; Verma, I.M.. "Knockdown transgenic mice generated by Silencing Lentiviral Vectors". In Gene Transfer: Delivery and Expression of DNA and RNA, 755-759. United States: Cold Spring Harbor Laboratory Press., 2005.
    Published
  3. Tiscornia, Gustavo; Singer, O.; Verma, I.M.. "Development of Lentiviral Vectors Expressing siRNA". In Gene Transfer: Delivery and Expression of DNA and RNA, 23-34. United States: Cold Spring Harbor Laboratory Press., 2005.
    Published
  4. Singer, O.; Tiscornia, Gustavo; Verma, I.M.. "siRNA delivery by Lentiviral Vectors: Design and Applications". In RNA Interference Technology. Cambridge, United Kingdom: Cambridge University Press, 2004.
    Published
Journal article
  1. Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell 57 4 (2022): 440-450.e7. http://dx.doi.org/10.1016/j.devcel.2021.12.008.
    10.1016/j.devcel.2021.12.008
  2. Vergaro, Paula; Tiscornia, Gustavo; Zambelli, Filippo; Rodríguez, Amelia; Santaló, Josep; Vassena, Rita. "Trophoblast attachment to the endometrial epithelium elicits compartment-specific transcriptional waves in an in-vitro model". Reproductive BioMedicine Online 42 1 (2021): 26-38. http://dx.doi.org/10.1016/j.rbmo.2020.08.037.
    10.1016/j.rbmo.2020.08.037
  3. Vergaro, Paula; Tiscornia, Gustavo; Barragán, Montserrat; García, Désirée; Rodriguez, Amelia; Santaló, Josep; Vassena, Rita. "Vaginal microbiota profile at the time of embryo transfer does not affect live birth rate in IVF cycles with donated oocytes". Reproductive BioMedicine Online 38 6 (2019): 883-891. http://dx.doi.org/10.1016/j.rbmo.2018.12.019.
    10.1016/j.rbmo.2018.12.019
  4. Vergaro, Paula; Tiscornia, Gustavo; Rodríguez, Amelia; Santaló, Josep; Vassena, Rita. "Transcriptomic analysis of the interaction of choriocarcinoma spheroids with receptive vs. non-receptive endometrial epithelium cell lines: an in vitro model for human implantation". Journal of Assisted Reproduction and Genetics 36 5 (2019): 857-873. http://dx.doi.org/10.1007/s10815-019-01442-9.
    10.1007/s10815-019-01442-9
  5. Pinheiro, Gonçalo; Prata, Diogo Filipe; Araújo, Inês Maria; Tiscornia, Gustavo. "The African spiny mouse (Acomysspp.) as an emerging model for development and regeneration". Laboratory Animals 52 6 (2018): 565-576. http://dx.doi.org/10.1177/0023677218769921.
    10.1177/0023677218769921
  6. Santos, Dino; Tiscornia, Gustavo. "Induced Pluripotent Stem Cell Modeling of Gaucher’s Disease: What Have We Learned?". International Journal of Molecular Sciences 18 4 (2017): 888. http://dx.doi.org/10.3390/ijms18040888.
    10.3390/ijms18040888
  7. de la Mata, Mario; Cotán, David; Oropesa-Ávila, Manuel; Villanueva-Paz, Marina; de Lavera, Isabel; Álvarez-Córdoba, Mónica; Luzón-Hidalgo, Raquel; et al. "Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease". Orphanet Journal of Rare Diseases 12 1 (2017): http://dx.doi.org/10.1186/s13023-017-0574-8.
    10.1186/s13023-017-0574-8
  8. de la Mata, Mario; Cotán, David; Villanueva-Paz, Marina; de Lavera, Isabel; Álvarez-Córdoba, Mónica; Luzón-Hidalgo, Raquel; Suárez-Rivero, Juan; Tiscornia, Gustavo; Oropesa-Ávila, Manuel. "Mitochondrial Dysfunction in Lysosomal Storage Disorders". Diseases 4 4 (2016): 31. http://dx.doi.org/10.3390/diseases4040031.
    10.3390/diseases4040031
  9. Matias Santos, Dino; Rita, Ana Martins; Casanellas, Ignasi; Brito Ova, Adélia; Araújo, Inês Maria; Power, Deborah; Tiscornia, Gustavo. "Ear wound regeneration in the African spiny mouseAcomys cahirinus". Regeneration 3 1 (2016): 52-61. http://dx.doi.org/10.1002/reg2.50.
    10.1002/reg2.50
  10. Mena-Barragán, Teresa; Narita, Aya; Matias, Dino; Tiscornia, Gustavo; Nanba, Eiji; Ohno, Kousaku; Suzuki, Yoshiyuki; et al. "pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases". Angewandte Chemie International Edition 54 40 (2015): 11696-11700. http://dx.doi.org/10.1002/anie.201505147.
    10.1002/anie.201505147
  11. Tiscornia, G.; Lorenzo Vivas, E.; Matalonga, L.; Berniakovich, I.; Barragán Monasterio, M.; Eguizábal, C.; Gort, L.; et al. "Neuronopathic Gaucher's disease: Induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds". Human Molecular Genetics 22 4 (2013): 633-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873040393&partnerID=MN8TOARS.
    10.1093/hmg/dds471
  12. Tiscornia, G.; Monserrat, N.; Belmonte, J.C.I.. "Modelling long QT syndrome with iPS cells: Be still, my beating heart .". Circulation Research 108 6 (2011): 648-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953061450&partnerID=MN8TOARS.
    10.1161/RES.0b013e318216f0db
  13. Tiscornia, G.; Vivas, E.L.; Belmonte, J.C.I.. "Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells". Nature Medicine 17 12 (2011): 1570-1576. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856112882&partnerID=MN8TOARS.
    10.1038/nm.2504
  14. Tiscornia, G.; Izpisúa Belmonte, J.C.. "MicroRNAs in embryonic stem cell function and fate". Genes and Development 24 24 (2010): 2732-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650223089&partnerID=MN8TOARS.
    10.1101/gad.1982910
  15. Gonzalez, F.; Monasterio, M.B.; Tiscornia, G.; Pulido, N.M.; Vassena, R.; Morera, L.B.; Piza, I.R.; Belmonte, J.C.I.. "Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector". Proceedings of the National Academy of Sciences of the United States of America 106 22 (2009): 8918-8922. http://www.scopus.com/inward/record.url?eid=2-s2.0-67049155513&partnerID=MN8TOARS.
    10.1073/pnas.0901471106
  16. Raya, A.; Rodríguez-Piz, I.; Guenechea, G.; Vassena, R.; Navarro, S.; Barrero, M.J.; Consiglio, A.; et al. "Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells". Nature 460 7251 (2009): 53-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650095306&partnerID=MN8TOARS.
    10.1038/nature08129
  17. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of an shRNA into a lentiviral silencing vector: Version A". Cold Spring Harbor Protocols 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-79954586070&partnerID=MN8TOARS.
    10.1101/pdb.prot5009
  18. Aasen, T.; Raya, A.; Barrero, M.J.; Garreta, E.; Consiglio, A.; Gonzalez, F.; Vassena, R.; et al. "Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes". Nature Biotechnology 26 11 (2008): 1276-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-55749089875&partnerID=MN8TOARS.
    10.1038/nbt.1503
  19. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of an shRNA into a lentiviral silencing vector: Version B". Cold Spring Harbor Protocols 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-79954623559&partnerID=MN8TOARS.
    10.1101/pdb.prot5010
  20. Singer, O.; Tiscornia, G.; Ikawa, M.; Verma, I.M.. "Rapid generation of knockdown transgenic mice by silencing lentiviral vectors". Nature Protocols 1 1 (2006): 286-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250662301&partnerID=MN8TOARS.
    10.1038/nprot.2006.44
  21. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of lentiviral vectors expressing small interfering RNAs". Nature Protocols 1 1 (2006): 234-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250664283&partnerID=MN8TOARS.
    10.1038/nprot.2006.36
  22. Tiscornia, G.; Singer, O.; Verma, I.M.. "Production and purification of lentiviral vectors". Nature Protocols 1 1 (2006): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250666701&partnerID=MN8TOARS.
    10.1038/nprot.2006.37
  23. Tiscornia, G.; Tergaonkar, V.; Galimi, F.; Verma, I.M.. "CRE recombinase-inducible RNA interference mediated by lentiviral vectors". Proceedings of the National Academy of Sciences of the United States of America 101 19 (2004): 7347-7351. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442584612&partnerID=MN8TOARS.
    10.1073/pnas.0402107101
  24. Tiscornia, G.; Singer, O.; Ikawa, M.; Verma, I.M.. "A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA". Proceedings of the National Academy of Sciences of the United States of America 100 4 (2003): 1844-1848. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037452812&partnerID=MN8TOARS.
    10.1073/pnas.0437912100
  25. Phan, D.; Han, E.; Birrell, G.; Bonnal, S.; Duggan, L.; Esumi, N.; Gutstein, H.; et al. "Purification and characterization of human cell-cell adhesion molecule 1 (C-CAM1) expressed in insect cells". Protein Expression and Purification 21 2 (2001): 343-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035714994&partnerID=MN8TOARS.
    10.1006/prep.2000.1382
  26. Tiscornia, G.; Mahadevan, M.S.. "Myotonic dystrophy: The role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios". Molecular Cell 5 6 (2000): 959-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033638394&partnerID=MN8TOARS.
Distinctions

Award

2016 Contrato Torres Quevedo
Gobierno de España Ministerio de Ciencia e Innovación, Spain

Other distinction

2012 Genzyme Young Investigator Award
Genzyme Corporation, United States
2006 Ramon y Cajal Fellowship
2005 Kirchstein National Research Service Award