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Angelo M Figueiredo is an experienced Research Scientist devoted most of his career to application and development of nuclear magnetic resonance (NMR) spectroscopy as a major biophysical technique for structural & dynamical studies of biomolecules. He has been working as NMR facility manager at the NMR centre of Institute of Structural and Molecular Biology (ISMB) at University College London, UK. Here, has been involved and collaborating in multiple scientific projects, providing not only technical expertise but also leadership abilities, coordinating input from academic and postdoctoral staff, and students. As a problem solver with a passion for theoretical and technical detail he develops creative and effective solutions for the extend range of emerging problems, not only tools (i.e. programming skills - Python, Matlab and C++) but also new concepts and ideas. The range of projects and ideas involved span from physical-chemistry to life sciences is referee for specialised Journals from Royal Society of Chemistry and American Chemical Society. During his Phd and Postdoc studies have gained a broad range of scientific skills including ITC, DSC and EPR in order to explore biomolecular interactions and protein stability. Strong interpersonal skills including mentoring, coaching, collaborating and team building (Supervision of 1 PhD Student, 2 Master Students and 4 Diploma Students; Lecturer/Tutor in seminars/courses across Europe) Able to develop and organise project ideas in order to delivery and present research results (publications, conferences, meetings), as well as management (funding applications, grants, awards) and communication skills
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Identificação

Identificação pessoal

Nome completo
Angelo Miguel Mendes Pinto de Figueiredo

Nomes de citação

  • Figueiredo, Angelo M

Identificadores de autor

Ciência ID
1E19-3AC2-88C9
ORCID iD
0000-0001-7039-5341

Endereços de correio eletrónico

  • amfigueiredo@qui.uc.pt (Profissional)

Moradas

  • NMR Lab Chemistry Department - University Coimbra, Rua Larga 2, 3004-535, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biofísica
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês (Idioma materno)
Formação
Grau Classificação
2011/07/19
Concluído
 Biomolecular NMR (Doctor of Philosophy)
Especialização em Protein Folding, NMR Spectroscopy
University of East Anglia School of Chemistry, Reino Unido

University of Leeds School of Molecular and Cellular Biology, Reino Unido
"Navigation of the Folding Landscape of Colicin Immunity Proteins" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/06/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/09/01 - 2024/06/30 Dirigente de laboratório, instituto, museu, centro ou observatório University College London Division of Biosciences, Reino Unido
Institute of Structural and Molecular Biology Research Department of Structural and Molecular Biology, Reino Unido
Projetos

Bolsa

Designação Financiadores
2013/07 - 2016/06 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
Provided by PTCRIS: 127013
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Julian O. Streit; Ivana V. Bukvin; Sammy H. S. Chan; Shahzad Bashir; Lauren F. Woodburn; Tomasz Wlodarski; Angelo Miguel Figueiredo; et al. "The ribosome lowers the entropic penalty of protein folding". Nature (2024): https://doi.org/10.1038/s41586-024-07784-4.
    10.1038/s41586-024-07784-4
  2. Tabor, Alethea; Darling, William; Wieske, Lianne; Cook, Declan; Aliev, Abil; Caron, Laurent; Humphrys, Emily J; et al. Autor correspondente: Tabor, Alethea. "The Influence of Disulfide, Thioacetal and Lanthionine-Bridges on the Conformation of a Macrocyclic Peptide". Chemistry – A European Journal (2024): http://dx.doi.org/10.1002/chem.202401654.
    Acesso aberto • No prelo • 10.1002/chem.202401654
  3. Pettitt, Alice J.; Shukla, Vaibhav K.; Newton, Lydia S.; Figueiredo, Angelo M.; McCarthy, Stephen; Tabor, Alethea B.; Heller, Gabriella T.; Lorenz, Chris D.; Hansen, D. Flemming. "Atomistic ensemble resolution of an intrinsically disordered peptide which undergoes proline cis/trans isomerisation". Biophysical Journal 123 3 (2024): 25a. http://dx.doi.org/10.1016/j.bpj.2023.11.256.
    Publicado • 10.1016/j.bpj.2023.11.256
  4. Gabriella T. Heller; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; D. Flemming Hansen. "Picosecond Dynamics of a Small Molecule in Its Bound State with an Intrinsically Disordered Protein". Journal of the American Chemical Society (2024): https://doi.org/10.1021/jacs.3c11614.
    10.1021/jacs.3c11614
  5. Giuseppe Nicastro; Giancarlo Abis; Pierre Klein; Sofia Esteban-Serna; Christopher Gallagher; Belen Chaves-Arquero; Yuyang Cai; et al. "Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers". Nucleic Acids Research (2023): https://doi.org/10.1093/nar/gkad534.
    10.1093/nar/gkad534
  6. Rachael Dickman; Serena A. Mitchell; Angelo M. Figueiredo; D. Flemming Hansen; Alethea B. Tabor. "Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B". The Journal of Organic Chemistry (2019): https://doi.org/10.1021/acs.joc.9b01253.
    10.1021/acs.joc.9b01253
  7. Fabian Blombach; Darya Ausiannikava; Angelo Miguel Figueiredo; Zoja Soloviev; Tanya Prentice; Mark Zhang; Nanruoyi Zhou; et al. "Structural and functional adaptation of Haloferax volcanii TFEa/ß". Nucleic Acids Research 46 5 (2018): 2308-2320. https://doi.org/10.1093%2Fnar%2Fgkx1302.
    10.1093/nar/gkx1302
  8. Karola Gerecht; Angelo Miguel Figueiredo; D. Flemming Hansen. "Determining rotational dynamics of the guanidino group of arginine side chains in proteins by carbon-detected NMR". Chemical Communications 53 72 (2017): 10062-10065. https://doi.org/10.1039/C7CC04821A.
    10.1039/C7CC04821A
  9. Figueiredo, Angelo; Veeramuthu, Sivanandam; Millet, Oscar; Cabrita, Eurico. "Breaking the deleterious effect of urea-unfolded state: consequences for the reversibility of inter-mediate species". Protein Science (2015): https://publons.com/wos-op/publon/20527642/.
  10. Silva, Micael; Figueiredo, Angelo Miguel; Cabrita, Eurico J.. "Epitope mapping of imidazolium cations in ionic liquid-protein interactions unveils the balance between hydrophobicity and electrostatics towards protein destabilisation". Physical Chemistry Chemical Physics (2014):
    10.1039/C4CP03534H
  11. Figueiredo, Angelo M. "Conformational dynamics is more important than helical propensity for the folding of the all a-helical protein Im7". Protein Science (2013): http://dx.doi.org/10.1002/pro.2372.
    10.1002/pro.2372
  12. Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita. "Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes". American Journal of Physiology-Endocrinology and Metabolism 305 4 (2013): E465-E474.
    10.1152/ajpendo.00245.2013
  13. Figueiredo, Angelo Miguel; Sardinha, Joao; Moore, Geoffrey R.; Cabrita, Eurico J.. "Protein destabilisation in ionic liquids: the role of preferential interactions in denaturation". Physical Chemistry Chemical Physics 15 45 (2013): 19632-19643.
    10.1039/C3CP53395F
  14. Figueiredo, Angelo Miguel; Moore, Geoffrey R.; Whittaker, Sara B. -M.. "Understanding how small helical proteins fold: conformational dynamics of Im proteins relevant to their folding landscapes". Biochemical Society Transactions 40 (2012): 424-428.
    10.1042/BST20110739
  15. Knowling, Stuart E.; Figueiredo, Angelo Miguel; Whittaker, Sara B-M.; Moore, Geoffrey R.; Radford, Sheena E.. "Amino Acid Insertion Reveals a Necessary Three-Helical Intermediate in the Folding Pathway of the Colicin E7 Immunity Protein Im7". Journal of Molecular Biology 392 4 (2009): 1074-1086.
    10.1016/j.jmb.2009.07.085
  16. Lopez-Cortes, A; Bursakov, S; Figueiredo, A; Thapper, AE; Todorovic, S; Moura, JJG; Ollivier, B; Moura, I; Fauque, G. "Purification and preliminary characterization of tetraheme cytochrome c(3) and adenylylsulfate reductase from the peptidolytic sulfate-reducing bacterium Desulfovibrio aminophilus DSM 12254". Bioinorganic Chemistry and Applications 3 1-2 (2005): 81-91.
    10.1155/BCA.2005.81
Poster em conferência
  1. Silva, Micael S.; Viegas, Aldino; Philip O'Toole; Figueiredo, Angelo M; Cabrita, Eurico J.. "Choline glutamate modulates protein folding and stability: an NMR view". Trabalho apresentado em 2020 CCPN Conference online, 2020.
Pré-impressão
  1. Alice J. Pettitt; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; Lydia S. Newton; Stephen McCarthy; Alethea B. Tabor; Gabriella T. Heller; Christian D. Lorenz; D. Flemming Hansen. "An integrative characterisation of prolinecisandtransconformers in a disordered peptide". 2024. https://doi.org/10.1101/2024.05.14.594077.
    10.1101/2024.05.14.594077
  2. Gabriella T. Heller; Vaibhav Kumar Shukla; Angelo M. Figueiredo; D. Flemming Hansen. "Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR19F transverse spin-relaxation". 2023. https://doi.org/10.1101/2023.05.03.539297.
    10.1101/2023.05.03.539297
Relatório
  1. Figueiredo, Angelo M; Cabrita, Eurico J.. 2013. GLOBAL ACTIVITY REPORT (Portuguese Nuclear Magnetic Resonance Network, PTNMR 2010-2012). http://ptnmr.dq.ua.pt/images/Global-Activity-Report-PTNMR-2010-2012.pdf.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/24 Latest developments & applications of Artificial Intelligence (AI) in NMR Spectroscopy - Deep Learning Tools in NMR Annual meeting of UK Magnetic Resonance Facilities (UKMRM)
Royal Society of Chemistry, University of Birmingham (Birmingham, Reino Unido)
2019/07/17 A NMR approach to characterise guanidino group of arginine side chains at macromolecular protein interfaces XXV Portuguese Chemical Meeting
Sociedade Portuguesa Química (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017/01/01 - Atual NMR investigation of osmolytes modulation of protein structure and dynamics and its relation to protein misfolding diseases
Coorientador
 MolBio (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2013/01/01 - Atual 3rd Hands on course NMR based protein interaction studies (2013)
Oficina (workshop)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/01/01 - Atual 2nd Hands on course on ligand based NMR interactions studies (2011/01/02)
Oficina (workshop) (Coorganizador)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/04/14 - 2018/04/16 COST CM1306 WG3 Workshop – Emerging Magnetic Resonance Techniques to Study Dynamic Molecular Machines (2018/04/14)
Oficina (workshop) (Outra)
2012/12/18 - 2012/12/20 To provide theoretical and practical training in important aspects of aligned media for structural elucidation of small molecules and the measurement of residual dipolar couplings (RDC) in NMR spectroscopy (2012/12/18 - 2012/12/20)
Oficina (workshop) (Coorganizador)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/06/30 - 2024/07/05 Poster Presentation - The effect of the ribosome on the conformational ensemble of an unfolded nascent chain
Congresso
 20th European Magnetic Resonance Congress
Real Sociedad Espanola de Quimica, Espanha

CIC bioGUNE, Espanha

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2014 - Atual European Instruct Course/COST course on Integrative Structural Biology tools for the study of protein-ligand interactions (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2020/04/30 Biomolecular NMR Protein Structure and Function Module (BIOC0029) (Bachelor) University College London Division of Biosciences, Reino Unido