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Identificação

Identificação pessoal

Nome completo
Antonio Brehm

Nomes de citação

  • Brehm, António Manuel Dias
  • Brehm, Antonio

Identificadores de autor

Ciência ID
3613-8D1F-0EDF
ORCID iD
0000-0003-3168-5340
Scopus Author Id
Author ID 7006085833

Telefones

Telemóvel
  • 962843599 (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Outras Ciências Médicas
  • Humanidades - História e Arqueologia - História
  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Formação
Grau Classificação
2002
Concluído
 n/a (Título de Agregado)
Especialização em Evolução
Universidade da Madeira, Portugal
 Aprovado Unanimidade
1990
Concluído
 Modelisation des Systemes Biologiques (Doutoramento)
Université de Lyon, França
"Ponho depois...." (TESE/DISSERTAÇÃO)
 Très Honorable
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2005/02/10 - Atual Professor Catedrático (Docente Universitário) Universidade da Madeira Faculdade de Ciências da Vida, Portugal
2001 - 2005 Professor Associado (Docente Universitário) Universidade da Madeira Faculdade de Ciências da Vida, Portugal
Universidade da Madeira, Portugal
1992/03 - 2001/09 Professor Auxiliar (Docente Universitário) Universidade da Madeira, Portugal
Projetos

Projeto

Designação Financiadores
2018 - 2022 De Portugal para África: revelando a origem africana da população portuguesa atual
PTDC/SOC-ANT/30316/2017
Investigador responsável
Universidade da Madeira Laboratório de Genética Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2001/01/01 - 2004/08/17 Polimorfismos genéticos e risco de doenças coronárias na Madeira. Relação com marcadores de risco cardiovascular e seu papel prognóstico
POCTI/MGI/38697/2001
Investigador responsável
Universidade da Madeira Laboratório de Genética Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1992 - 1995 Estudos de Diferenciação Genética ao Nível do ADN Nuclear e Mitocondrial em Drosophila subobscura das Ilhas da Macaronésia
STRD/C/BIO/381/92
Investigador responsável
Universidade da Madeira Laboratório de Genética Humana, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Pereira, Andreia; Mendonca, Maria Isabel; Borges, Sofia; Sousa, Ana Célia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; et al. "Additional value of a combined genetic risk score to standard cardiovascular stratification". Genetics and Molecular Biology 41 4 (2018): 766-774. http://dx.doi.org/10.1590/1678-4685-gmb-2017-0173.
    10.1590/1678-4685-gmb-2017-0173
  2. Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara; et al. "Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa População Portuguesa". Acta Médica Portuguesa 31 10 (2018): 542. http://dx.doi.org/10.20344/amp.9184.
    Acesso aberto • 10.20344/amp.9184
  3. Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana Isabel; et al. "A variante genética c825t da subunidade ß3 da proteína G associa-se com a hipertensão arterial numa população portuguesa". Revista Portuguesa de Cardiologia 37 6 (2018): 499-507. http://dx.doi.org/10.1016/j.repc.2017.09.018.
    Acesso aberto • 10.1016/j.repc.2017.09.018
  4. Brehm, António. "Sebastião e o cometa espantoso. O cometa de 1577, os avisos de céu e as crónicas sebastianistas". (2018): http://hdl.handle.net/10400.13/2281.
  5. Pereira, Andreia; Mendonça, Maria Isabel; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana Isabel; et al. "Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants". Abstract Background: Genetic risk score can quantify individual’s predisposition to coronary artery disease; however, its usefulness as an independent risk predictor remains inconclusive. Objective: To evaluate the incremental predictive value of a genetic risk score to traditional risk factors associated with coronary disease. Methods: Thirty-three genetic variants previously associated wit (2018): http://hdl.handle.net/10400.26/25692.
    10.5935/abc.20180107
  6. Pereira,Andreia; Mendonca,Maria Isabel; Borges,Sofia; Sousa,Ana Célia; Freitas,Sónia; Henriques,Eva; Rodrigues,Mariana; et al. "Additional value of a combined genetic risk score to standard cardiovascular stratification". The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 (2018): http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000500766.
    https://doi.org/10.1590/1678-4685-gmb-2017-0173
  7. Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana Isabel; et al. "A variante genética c825t da subunidade ß3 da proteína G associa-se com a hipertensão arterial numa população portuguesa". (2018): http://hdl.handle.net/10400.26/27893.
    10.1016/j.repc.2017.09.018
  8. Sousa, Ana Célia; Reis, Roberto Palma; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara; et al. "Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa População Portuguesa". Introdução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais.Objetivo: Avaliar a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais na eclosão desta patologia.Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860 hipertensos e 85 (2018): http://www.scopus.com/inward/record.url?scp=85055909462&partnerID=8YFLogxK.
    https://doi.org/10.20344/amp.9184
  9. Gomes, Iva; Pereira, Plácido J.P.; Harms, Sonja; Oliveira, Andréa M.; Schneider, Peter M.; Brehm, António. "Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: Inferences from a multiethnic population". Forensic Science International: Genetics 31 (2017): 89-94. http://dx.doi.org/10.1016/j.fsigen.2017.08.016.
    Acesso aberto • 10.1016/j.fsigen.2017.08.016
  10. Spínola, H.; Lemos, A.; Couto, A. R.; Parreira, B.; Soares, M.; Dutra, I.; Bruges-Armas, J.; Brehm, A.; Abreu, S.. "Human leucocyte antigens class II allele and haplotype association with Type 1 Diabetes in Madeira Island (Portugal)". International Journal of Immunogenetics 44 6 (2017): 305-313. http://dx.doi.org/10.1111/iji.12335.
    Acesso aberto • 10.1111/iji.12335
  11. Afilal, Driss; Basselam, Mohamed Amine; Brakez, Zahra; Chouham, Said; Brehm, António; Izaabel, El Hassan. "Genetic Polymorphism of Drug-Metabolizing Enzymes CYP2C9 and CYP2C19 in Moroccan Population". Genetic Testing and Molecular Biomarkers 21 5 (2017): 298-304. http://dx.doi.org/10.1089/gtmb.2016.0304.
    Acesso aberto • Publicado • 10.1089/gtmb.2016.0304
  12. Silventoinen, Karri; Gouveia, Élvio; Jelenkovic, Aline; Maia, José; Antunes, António M.; Carvalho, Miguel A A Pinheiro de; Brehm, António M; et al. "The Genetic Background of Metabolic Trait Clusters in Children and Adolescents". Metabolic Syndrome and Related Disorders 15 7 (2017): 329-336. http://hdl.handle.net/10400.13/2197.
    Acesso aberto • Publicado • 10.1089/met.2017.0013
  13. Sousa, Ana Célia; Mendonça, Maria I.; Pereira, Andreia; Gouveia, Sara; Freitas, Ana I.; Guerra, Graça; Rodrigues, Mariana; et al. "Synergistic Association of Genetic Variants with Environmental Risk Factors in Susceptibility to Essential Hypertension". (2017): http://hdl.handle.net/10400.26/28007.
    10.1089/gtmb.2017.0048
  14. Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Góis, Teresa; et al. "Relationship between ADD1 Gly460Trp gene polymorphism and essential hypertension in Madeira Island". Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from (2017): http://hdl.handle.net/10400.26/27891.
    10.1097/MD.0000000000007861
  15. Brehm, António Manuel Dias. "Auto de entrega do corpo de D. Sebastião: Ceuta, 10 de dezembro de 1578". (2017): http://hdl.handle.net/10400.13/1516.
  16. Pereira, Andreia; Mendonca, Maria Isabel; Sousa, Ana Célia; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; et al. "Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease". Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) have yielded conflicting results. Objective: The objective of this study was to evaluate long- term cardiovascular mortality according to the genetic risk score in a Southern European population with CAD. Methods: A cohort of 1464 CAD patien (2017): http://hdl.handle.net/10400.26/25696.
    10.1111/ijcp.12956
  17. Spínola, H.; Lemos, A.; Couto, A. R.; Parreira, B.; Soares, M.; Dutra, I.; Bruges-Armas, J.; Brehm, A.. "HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal)". International Journal of Immunogenetics 44 1 (2016): 27-31. http://dx.doi.org/10.1111/iji.12300.
    Acesso aberto • 10.1111/iji.12300
  18. Pereira, A.; Palma dos Reis, R.; Rodrigues, R.; Sousa, A. C.; Gomes, S.; Borges, S.; Ornelas, I.; et al. "Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease". Physiological Genomics 48 11 (2016): 810-815. http://dx.doi.org/10.1152/physiolgenomics.00059.2016.
    Acesso aberto • 10.1152/physiolgenomics.00059.2016
  19. Gomes, Iva; Brehm, António; Gusmão, Leonor; Schneider, Peter M.. "New sequence variants detected at DXS10148, DXS10074 and DXS10134 loci". Forensic Science International: Genetics 20 (2016): 112-116. http://dx.doi.org/10.1016/j.fsigen.2015.10.005.
    Acesso aberto • 10.1016/j.fsigen.2015.10.005
  20. Berenguer, Anabela G.; Rosa, Alexandra; Brehm, António. "Asthma—snapshot or motion picture?". Frontiers in Genetics 4 (2013): http://dx.doi.org/10.3389/fgene.2013.00073.
    Acesso aberto • 10.3389/fgene.2013.00073
  21. Kheradmand Kia, Sima; Verbeek, Elly; Engelen, Erik; Schot, Rachel; Poot, Raymond A.; de Coo, Irenaeus F.M.; Lequin, Maarten H.; et al. "RTTN Mutations Link Primary Cilia Function to Organization of the Human Cerebral Cortex". The American Journal of Human Genetics 91 3 (2012): 533-540. http://dx.doi.org/10.1016/j.ajhg.2012.07.008.
    Acesso aberto • 10.1016/j.ajhg.2012.07.008
  22. Brehm, Antonio ; Berenguer, Anabela Gonçalves; Câmara, Rita A. "Distribution of polymorphisms IL4-590 C/T and IL4 RP2 in the human populations of Madeira, Azores, Portugal, Cape Verde and Guinea-Bissau". 3 2 (2012): 179-183.
    Acesso aberto • Publicado
  23. Fernandes, Ana Teresa; Gonçalves, Rita; Gomes, Sara; Filon, Dvora; Nebel, Almut; Faerman, Marina; Brehm, António. "Y-chromosomal STRs in two populations from Israel and the Palestinian Authority Area: Christian and Muslim Arabs". Forensic Science International: Genetics 5 5 (2011): 561-562. http://dx.doi.org/10.1016/j.fsigen.2010.08.005.
    Acesso aberto • 10.1016/j.fsigen.2010.08.005
  24. Batini, C.; Ferri, G.; Destro-Bisol, G.; Brisighelli, F.; Luiselli, D.; Sanchez-Diz, P.; Rocha, J.; et al. "Signatures of the Preagricultural Peopling Processes in Sub-Saharan Africa as Revealed by the Phylogeography of Early Y Chromosome Lineages". Molecular Biology and Evolution 28 9 (2011): 2603-2613. http://dx.doi.org/10.1093/molbev/msr089.
    Acesso aberto • Publicado • 10.1093/molbev/msr089
  25. Berenguer, Alberto; Câmara, Rita A; Brehm, António D; Oliveira, Susana; Fernandes, Ana T. "Distribution of polymorphisms IL4 -590 C/T and IL4 RP2 in the human populations of Madeira, Azores, Portugal, Cape". (2011): http://hdl.handle.net/10400.26/29717.
  26. Spínola, Carla; Brehm, António; Spínola, Hélder. "Alpha-1-antitrypsin deficiency in the Cape Verde islands (Northwest Africa): high prevalence in a sub-Saharan population". (2010): http://hdl.handle.net/10400.13/2157.
  27. Spínola, Carla; Bruges-Armas, Jácome; Pereira, Conceição; Brehm, António; Spínola, Hélder. "Alpha-1-antitrypsin deficiency in Madeira (Portugal): the highest prevalence in the world". Alpha-1-antitrypsin (AAT) deficiency is a common genetic disease which affects both lung and liver. Early diagnosis can help asymptomatic patients to adjust their lifestyle choices in order to reduce the risk of Chronic Obstructive Pulmonary Disease (COPD). The determination of this genetic deficiency prevalence in Madeira Island (Portugal) population is important to clarify susceptibility and def (2009): http://hdl.handle.net/10400.13/2160.
  28. Saldanha, Nádia; Spínola, Carla; Santos, Margarida R.; Simões, Joaquim P.; Bruges-Armas, Jácome; Brehm, António; Spínola, Hélder. "HLA polymorphysms in Forros and Angolares from São Tomé Island (West Africa): evidence for the population origin". (2009): http://hdl.handle.net/10400.13/31.
  29. Spínola, C.; Bruges-Armas, J.; Brehm, A.; Spínola, H.. "HLA-A polymorphisms in four ethnic groups from Guinea-Bissau (West Africa) inferred from sequence-based typing". Tissue Antigens 72 6 (2008): 593-598. http://dx.doi.org/10.1111/j.1399-0039.2008.01147.x.
    Acesso aberto • 10.1111/j.1399-0039.2008.01147.x
  30. Prieto, L.; Alonso, A.; Alves, C.; Crespillo, M.; Montesino, M.; Picornell, A.; Brehm, A.; et al. "2006 GEP-ISFG collaborative exercise on mtDNA: reflections about interpretation, artefacts, and DNA mixtures". Forensic Science International: Genetics 2 2 (2008): 126-133. http://dx.doi.org/10.1016/j.fsigen.2007.10.010.
    Acesso aberto • 10.1016/j.fsigen.2007.10.010
  31. Gonçalves, Rita; Parik, Jüri; Freitas, Ana Isabel; Jesus, José; Villems, Richard; Brehm, António. "Identification of endangered petrel species from poor quality feather debris using cytochrome b sequences". Forensic Science International 174 1 (2008): 87-88. http://dx.doi.org/10.1016/j.forsciint.2006.10.024.
    10.1016/j.forsciint.2006.10.024
  32. Freitas, Ana I.; Mendonça, Isabel; Guerra, Graça; Brión, Maria; Reis, Roberto P.; Carracedo, Angel; Brehm, António. "Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal)". (2008): http://hdl.handle.net/10400.26/28009.
    10.1016/j.thromres.2008.02.005
  33. Fernandes, A. T.; Rosa, A.; Gonçalves, R.; Jesus, J.; Brehm, A.. "The Y-chromosome short tandem repeats variation within haplogroup E3b: Evidence of recurrent mutation in SNP". American Journal of Human Biology 20 2 (2008): 185-190. http://dx.doi.org/10.1002/ajhb.20693.
    10.1002/ajhb.20693
  34. Jesus, José; James Harris, D.; Brehm, António. "Relationships of Afroablepharus Greer, 1974 skinks from the Gulf of Guinea islands based on mitochondrial and nuclear DNA: Patterns of colonization and comments on taxonomy". Molecular Phylogenetics and Evolution 45 3 (2007): 904-914. http://dx.doi.org/10.1016/j.ympev.2007.08.011.
    10.1016/j.ympev.2007.08.011
  35. Gonçalves, Rita; Spínola, Hélder; Brehm, António. "Y-Chromosome lineages in São Tomé e Príncipe Islands: evidence of european in¿uence". The Y-chromosome haplogroup composition of the population of Sa ˜ o Tome ´ e Pri ´ ncipe (STP) archipelago was analyzed using 25 biallelic markers and compared with popula- tions of different origins from Europe, Africa, and the Middle East. Two main Y-chromosome haplogroups were found: E3a, very common among sub-Saharans accounts for 84.2% of the pa- ternal lineages and R1b, typical of West Euras (2007): http://hdl.handle.net/10400.13/2147.
  36. Spínola, Hélder; Bruges-Armas, Jácome; Brehm, António. "Discrepancies in HLA Typing by PCR-SSOP and SBT Techniques: a case study". Six hundred twenty-one samples from Portugal, the Cabo Verde archipelago, and Guinea-Bissau were typed for HLA-A, HLA-B, and HLADRB1usingthepolymerasechainreaction–sequence-speci¿coligonucleotide probe (PCR-SSOP) method and the sequence-based typing (SBT) method to characterizeandcomparediscrepanciesbetweenthetwomethods.Fifty-three alleles (4.27% of 1,242 chromosomes typed) identi¿ed by the PCR-SS (2007): http://hdl.handle.net/10400.13/1351.
  37. Rosa, Alexandra; Ornelas, Carolina; Jobling, Mark A; Brehm, António; Villems, Richard. "Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective". BMC Evolutionary Biology 7 1 (2007): 124. http://dx.doi.org/10.1186/1471-2148-7-124.
    10.1186/1471-2148-7-124
  38. Gonçalves, Rita; Spínola, Hélder; Brehm, António. "Y-chromosome lineages in São Tomé e Príncipe islands: Evidence of European influence". American Journal of Human Biology 19 3 (2007): 422-428. http://dx.doi.org/10.1002/ajhb.20604.
    10.1002/ajhb.20604
  39. Crespillo, Manuel; Paredes, Miguel R.; Prieto, Lourdes; Montesino, Marta; Salas, Antonio; Albarran, Cristina; V, Álvarez-Iglesias; et al. "Results of the 2003–2004 GEP-ISFG collaborative study on mitochondrial DNA: Focus on the mtDNA profile of a mixed semen-saliva stain". Forensic Science International 160 2-3 (2006): 157-167. http://dx.doi.org/10.1016/j.forsciint.2005.09.005.
    10.1016/j.forsciint.2005.09.005
  40. Fernandes, A. T.. "DAZ gene copies: evidence of Y chromosome evolution". Molecular Human Reproduction 12 8 (2006): 519-523. http://dx.doi.org/10.1093/molehr/gal051.
    10.1093/molehr/gal051
  41. Spínola, Hélder; Bruges-Armas, Jácome; Mora, Marian Gantes; Middleton, Derek; Brehm, António. "HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: Footprints from different origins". Molecular Immunology 43 10 (2006): 1726-1728. http://dx.doi.org/10.1016/j.molimm.2005.10.001.
    10.1016/j.molimm.2005.10.001
  42. Rosa, Alexandra; Ornelas, Carolina; Brehm, António; Villems, Richard. "Population data on 11 Y-chromosome STRs from Guiné-Bissau". Forensic Science International 157 2-3 (2006): 210-217. http://dx.doi.org/10.1016/j.forsciint.2005.04.005.
    10.1016/j.forsciint.2005.04.005
  43. Spínola, Hélder; Bruges-Armas, Jácome; Mora, Marian Gantes; Middleton, Derek; Brehm, António. "HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: footprints from different origins". Human leukocyte antigen (HLA)-A, HLA-B, and HLA-DRB1 polymorphisms were examined in Madeira Island populations. The data was obtained at high-resolution level, using sequence-based typing (SBT). The most frequent alleles at each loci were: A*020101 (24.6%), B*5101 (9.7%), B*440201 (9.2%), and DRB1*070101 (15.7%). The predominant three-loci haplotypes in Madeira were A*020101–B*510101–DRB1*130101 ( (2006): http://hdl.handle.net/10400.13/2162.
  44. Freitas, Tamira.; Brehm, António.; Fernandes, Ana Teresa.. "Frequency of the CCR5-¿32 Mutation in the Atlantic Island Populations of Madeira, the Azores, Cabo Verde, and São Tomé e Príncipe". Human Biology 78 6 (2006): 697-703. http://dx.doi.org/10.1353/hub.2007.0011.
    10.1353/hub.2007.0011
  45. Jesus, José; Harris, D. James; Brehm, António. "Phylogeography of Mabuya maculilabris (Reptilia) from São Tomé Island (Gulf of Guinea) inferred from mtDNA sequences". Molecular Phylogenetics and Evolution 37 2 (2005): 503-510. http://dx.doi.org/10.1016/j.ympev.2005.04.032.
    10.1016/j.ympev.2005.04.032
  46. Spínola, Hélder; Bruges-Armas, Jácome; Middleton, Derek; Brehm, António. "HLA Polymorphisms in Cabo Verde and Guiné-Bissau Inferred From Sequence-Based Typing". Human Immunology 66 10 (2005): 1082-1092. http://dx.doi.org/10.1016/j.humimm.2005.09.001.
    10.1016/j.humimm.2005.09.001
  47. Spinola, H.; Brehm, A.; Bettencourt, B.; Middleton, D.; Bruges-Armas, J.. "HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands". Tissue Antigens 66 3 (2005): 217-230. http://dx.doi.org/10.1111/j.1399-0039.2005.00471.x.
    10.1111/j.1399-0039.2005.00471.x
  48. Spinola, H.; Middleton, D.; Brehm, A.. "HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa". Tissue Antigens 66 1 (2005): 26-36. http://dx.doi.org/10.1111/j.1399-0039.2005.00430.x.
    10.1111/j.1399-0039.2005.00430.x
  49. Gonçalves, Rita; Freitas, Ana; Branco, Marta; Rosa, Alexandra; Fernandes, Ana T.; Zhivotovsky, Lev A.; Underhill, Peter A.; Kivisild, Toomas; Brehm, António. "Y-chromosome Lineages from Portugal, Madeira and Açores Record Elements of Sephardim and Berber Ancestry". Annals of Human Genetics 69 4 (2005): 443-454. http://dx.doi.org/10.1111/j.1529-8817.2005.00161.x.
    10.1111/j.1529-8817.2005.00161.x
  50. Martins, N.; Lopes, I.; Brehm, A.; Ribeiro, R.. "Cytochrome B Gene Partial Sequence and RAPD Analysis of Two Daphnia longispina Lineages Differing in their Resistance to Copper". Bulletin of Environmental Contamination and Toxicology 74 4 (2005): 755-760. http://dx.doi.org/10.1007/s00128-005-0646-7.
    10.1007/s00128-005-0646-7
  51. Jesus, José; Brehm, Antonio; Harris, D. James. "Phylogenetic relationships of Hemidactylus geckos from the Gulf of Guinea islands: patterns of natural colonizations and anthropogenic introductions estimated from mitochondrial and nuclear DNA sequences". Molecular Phylogenetics and Evolution 34 3 (2005): 480-485. http://dx.doi.org/10.1016/j.ympev.2004.11.006.
    10.1016/j.ympev.2004.11.006
  52. Salas, Antonio; Prieto, Lourdes; Montesino, Marta; Albarrán, Cristina; Arroyo, Eduardo; Paredes-Herrera, Miguel R.; Di Lonardo, Ana Ma; et al. "Mitochondrial DNA error prophylaxis: assessing the causes of errors in the GEP’02–03 proficiency testing trial". Forensic Science International 148 2-3 (2005): 191-198. http://dx.doi.org/10.1016/j.forsciint.2004.06.008.
    10.1016/j.forsciint.2004.06.008
  53. Spínola, Hélder; Bruges-Armas, Jácome; Middleton, Derek; Brehm, António. "HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing". Human leukocyte antigen (HLA)-A, -B, and -DRB1 polymorphisms were examined in the Cabo Verde and Guiné-Bissau populations. The data were obtained at high-resolution level, using sequence-based typing. The most frequent alleles in each locus was: A*020101 (16.7% in Guiné-Bissau and 13.5% in Cabo Verde), B*350101 (14.4% in Guiné-Bissau and 13.2% in Cabo Verde), DRB1*1304 (19.6% in Guiné-Bissau), and (2005): http://hdl.handle.net/10400.13/2163.
  54. Peixoto, M. J.; Gonzales, T.; Spínola, Hélder; Couto, A. R.; Gantes Mora, M.; Brehm, António; Santos, M. R.; Garrett, F.; Bruges-Armas, J.. "Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias". A associação da molécula HLA-B27 com a espondilite anquilosante (AS) e outras espondilartropatias (SpA), permanece como uma das mais fortes verificada entre moléculas HLA e doenças humanas. Desde que foi descrita, em 1973, tem sido alvo de intensa investigação na tentativa de compreender o mecanismo patogénico que lhe está subjacente. Este artigo tem como objectivo fazer uma revisão dos conhecimen (2005): http://hdl.handle.net/10400.13/1352.
  55. Kivisild, Toomas; Reidla, Maere; Metspalu, Ene; Rosa, Alexandra; Brehm, Antonio; Pennarun, Erwan; Parik, Jüri; et al. "Ethiopian Mitochondrial DNA Heritage: Tracking Gene Flow Across and Around the Gate of Tears". The American Journal of Human Genetics 75 5 (2004): 752-770. http://dx.doi.org/10.1086/425161.
    10.1086/425161
  56. Rosa, Alexandra; Brehm, Antonio; Kivisild, Toomas; Metspalu, Ene; Villems, Richard. "MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region". Annals of Human Genetics 68 4 (2004): 340-352. http://dx.doi.org/10.1046/j.1529-8817.2004.00100.x.
    10.1046/j.1529-8817.2004.00100.x
  57. Rootsi, Siiri; Kivisild, Toomas; Benuzzi, Giorgia; Help, Hela; Bermisheva, Marina; Kutuev, Ildus; Barac, Lovorka; et al. "Phylogeography of Y-Chromosome Haplogroup I Reveals Distinct Domains of Prehistoric Gene Flow in Europe". The American Journal of Human Genetics 75 1 (2004): 128-137. http://dx.doi.org/10.1086/422196.
    10.1086/422196
  58. Brehm, António; Harris, D.James; Hernández, Mariano; Perez, José A.; Larruga, José M.; Pinto, Francisco M.; González, Ana M.. "Phylogeography of Drosophila subobscura from north Atlantic islands inferred from mtDNA A+T rich region sequences". Molecular Phylogenetics and Evolution 30 3 (2004): 829-834. http://dx.doi.org/10.1016/j.ympev.2003.10.018.
    10.1016/j.ympev.2003.10.018
  59. Isidro, Gl¿ria; Laranjeira, Francisco; Pires, Ana; Leite, J¿lio; Regateiro, Fernando; e Sousa, F. Castro; Soares, Jos¿; et al. "Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas". Human Mutation 24 4 (2004): 353-354. http://dx.doi.org/10.1002/humu.9282.
    10.1002/humu.9282
  60. Brehm, Ant¿nio; Pereira, Lu¿sa; Kivisild, Toomas; Amorim, Ant¿nio. "Mitochondrial portraits of the Madeira and A¿ores archipelagos witness different genetic pools of its settlers". Human Genetics 114 1 (2003): 77-86. http://dx.doi.org/10.1007/s00439-003-1024-3.
    10.1007/s00439-003-1024-3
  61. Gon¿alves, Rita; Rosa, Alexandra; Freitas, Ana; Fernandes, Ana; Kivisild, Toomas; Villems, Richard; Brehm, Ant¿nio. "Y-chromosome lineages in Cabo Verde Islands witness the diverse geographic origin of its first male settlers". Human Genetics 113 6 (2003): 467-472. http://dx.doi.org/10.1007/s00439-003-1007-4.
    10.1007/s00439-003-1007-4
  62. Fernandes, Ana; Brehm, António. "Y-chromosome STR haplotypes in the Açores Archipelago (Portugal)". Forensic Science International 135 3 (2003): 239-242. http://dx.doi.org/10.1016/s0379-0738(03)00202-0.
    10.1016/s0379-0738(03)00202-0
  63. Fernandes, A. T.; Velosa, R.; Jesus, J.; Carracedo, A.; Brehm, A.. "Genetic Differentiation of the Cabo Verde Archipelago Population Analysed by STR Polymorphisms". Annals of Human Genetics 67 4 (2003): 340-347. http://dx.doi.org/10.1046/j.1469-1809.2003.00029.x.
    10.1046/j.1469-1809.2003.00029.x
  64. González, Ana M.; Brehm, Antonio; Pérez, José A.; Maca-Meyer, Nicole; Flores, Carlos; Cabrera, Vicente M.. "Mitochondrial DNA affinities at the Atlantic fringe of Europe". American Journal of Physical Anthropology 120 4 (2003): 391-404. http://dx.doi.org/10.1002/ajpa.10168.
    10.1002/ajpa.10168
  65. Brehm, A.; Jesus, J.; Spi´nola, H.; Alves, C.; Vicente, L.; Harris, D.J.. "Phylogeography of the Madeiran endemic lizard Lacerta dugesii inferred from mtDNA sequences". Molecular Phylogenetics and Evolution 26 2 (2003): 222-230. http://dx.doi.org/10.1016/s1055-7903(02)00310-x.
    10.1016/s1055-7903(02)00310-x
  66. Brehm, António; James Harris, D.; Alves, Cíntia; Jesus, José; Thomarat, Fabienne; Vicente, Luís. "Structure and Evolution of the Mitochondrial DNA Complete Control Region in the Lizard Lacerta dugesii (Lacertidae, Sauria)". Journal of Molecular Evolution 56 1 (2003): 46-53. http://dx.doi.org/10.1007/s00239-002-2379-0.
    10.1007/s00239-002-2379-0
  67. Gonçalves, Rita; Jesus, José; Fernandes, Ana Teresa; Brehm, António. "Genetic profile of a multi-ethnic population from Guiné-Bissau (west African coast) using the new PowerPlex® 16 System kit". Forensic Science International 129 1 (2002): 78-80. http://dx.doi.org/10.1016/s0379-0738(02)00204-9.
    10.1016/s0379-0738(02)00204-9
  68. Fernandes, Ana Teresa; Brehm, António. "Population data of five STRs in three regions from Portugal". Forensic Science International 129 1 (2002): 72-74. http://dx.doi.org/10.1016/s0379-0738(02)00202-5.
    10.1016/s0379-0738(02)00202-5
  69. Velosa, Rute Gomes; Fernandes, Ana Teresa; Brehm, António. "Genetic profile of the Açores Archipelago population using the new PowerPlex®16 System Kit". Forensic Science International 129 1 (2002): 68-71. http://dx.doi.org/10.1016/s0379-0738(02)00203-7.
    10.1016/s0379-0738(02)00203-7
  70. SP??NOLA, H.; BREHM, A.; WILLIAMS, F.; JESUS, J.; MIDDLETON, D.. "Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route". Annals of Human Genetics 66 4 (2002): 285-296. http://dx.doi.org/10.1017/s0003480002001185.
    10.1017/s0003480002001185
  71. Lepetit, D.; Brehm, A.; Fouillet, P.; Biemont, C.. "Insertion polymorphism of retrotransposable elements in populations of the insular, endemic species Drosophila madeirensis". Molecular Ecology 11 3 (2002): 347-354. http://dx.doi.org/10.1046/j.1365-294x.2002.01470.x.
    10.1046/j.1365-294x.2002.01470.x
  72. Fernandes, Ana Teresa; Brehm, Antonio ; Alves, Cíntia; Gusmão, Leonor; Amorim, António. "Genetic profile of the Madeira Archipelago population using the new PowerPlex16 System kit". Forensic Science International 125 2-3 (2002): 281-283. http://dx.doi.org/10.1016/s0379-0738(01)00625-9.
    10.1016/s0379-0738(01)00625-9
  73. BREHM, A.; PEREIRA, L.; BANDELT, H.-J.; PRATA, M. J.; AMORIM, A.. "Mitochondrial portrait of the Cabo Verde archipelago: the Senegambian outpost of Atlantic slave trade". Annals of Human Genetics 66 1 (2002): 49-60. http://dx.doi.org/10.1017/s0003480001001002.
    10.1017/s0003480001001002
  74. Brehm, A.; Harris, D. J.; Hernández, M.; Cabrera, V. M.; Larruga, J. M.; Pinto, F. M.; González, A. M.. "Structure and evolution of the mitochondrial DNA complete control region in the Drosophila subobscura subgroup". Insect Molecular Biology 10 6 (2001): 573-578. http://dx.doi.org/10.1046/j.0962-1075.2001.00295.x.
    10.1046/j.0962-1075.2001.00295.x
  75. Brehm, António; Khadem, Mahnaz; Jesus, José; Andrade, Paula; Vicente, Luis. "Lack of congruence between morphometric evolution and genetic differentiation suggests a recent dispersal and local habitat adaptation of the Madeiran lizard Lacerta dugesii". Genetics Selection Evolution 33 6 (2001): http://dx.doi.org/10.1186/1297-9686-33-6-671.
    10.1186/1297-9686-33-6-671
  76. BANDELT, H.-J.; ALVES-SILVA, J.; GUIMARAES, P. E. M.; SANTOS, M. S.; BREHM, A.; PEREIRA, L.; COPPA, A.; et al. "Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade". Annals of Human Genetics 65 6 (2001): 549-563. http://dx.doi.org/10.1046/j.1469-1809.2001.6560549.x.
    10.1046/j.1469-1809.2001.6560549.x
  77. Fernandes, Ana Teresa; Brehm, António; Gusmão, Leonor; Amorim, António. "Y-chromosome STR haplotypes in the Madeira archipelago population". Forensic Science International 122 2-3 (2001): 178-180. http://dx.doi.org/10.1016/s0379-0738(01)00495-9.
    10.1016/s0379-0738(01)00495-9
  78. Brehm, A; Jesus, J; Pinheiro, M; Harris, D.J. "Relationships of Scincid Lizards (Mabuya spp; Reptilia: Scincidae) from the Cape Verde Islands Based on Mitochondrial and Nuclear DNA Sequences". Molecular Phylogenetics and Evolution 19 2 (2001): 311-316. http://dx.doi.org/10.1006/mpev.2001.0946.
    10.1006/mpev.2001.0946
  79. Spínola, Hélder; Brehm, António. "Genetic diversity of the Macaronesian leafy liverwort Porella canariensis inferred from RAPD markers". Plant colonization of the North Atlantic raises the intriguing question of the relationships between extant island species with their continental counterparts (European, African, and American), which may provide clues to past geographic distribution and colonization history. It has been suggested that during past glaciations, many plant species with typical Mediterranean distributions survived in (2001): http://hdl.handle.net/10400.13/1394.
  80. Cizeron, G.; Lemeunier, F.; Loevenbruck, C.; Brehm, A.; Biemont, C.. "Distribution of the retrotransposable element 412 in Drosophila species". Molecular Biology and Evolution 15 12 (1998): 1589-1599. http://dx.doi.org/10.1093/oxfordjournals.molbev.a025887.
    10.1093/oxfordjournals.molbev.a025887
  81. Pinto, F. M.; Brehm, A.; Hernández, M.; Larruga, J. M.; González, A.M.; Cabrera, V. M.. "Population Genetic Structure and Colonization Sequence of Drosophila subobscura in the Canaries and Madeira Atlantic Islands as Inferred by Autosomal, Sex-Linked and mtDNA Traits". Journal of Heredity 88 2 (1997): 108-114. http://dx.doi.org/10.1093/oxfordjournals.jhered.a023067.
    10.1093/oxfordjournals.jhered.a023067
  82. Brehm, Antonio; Krimbas, Costas B. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding homologies of the chromosomal regions. IV. Element C". Heredity 70 2 (1993): 214-220. http://dx.doi.org/10.1038/hdy.1993.31.
    10.1038/hdy.1993.31
  83. Brehm, Antonio; Krimbas, Costas B.. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding homologies of chromosomal regions. III. Element D". Genome 35 6 (1992): 1075-1085. http://dx.doi.org/10.1139/g92-165.
    10.1139/g92-165
  84. Brehm, Antonio; Krimbas, Costas B.; Sourdis, John; Cariou, Marie-Louise. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding homologies of chromosomal regions. I. Element B". Genome 34 3 (1991): 464-471. http://dx.doi.org/10.1139/g91-070.
    10.1139/g91-070
  85. Brehm, A.; Krimbas, C. B.. "Inversion Polymorphism in Drosophila obscura". Journal of Heredity 82 2 (1991): 110-117. http://dx.doi.org/10.1093/oxfordjournals.jhered.a111044.
    10.1093/oxfordjournals.jhered.a111044
  86. Brehm, A; Krimbas, C B. "Evolution of the obscura group Drosophila species.: III. Phylogenetic relationships in the subobscura cluster based on homologies of chromosome A". Heredity 65 2 (1990): 269-275. http://dx.doi.org/10.1038/hdy.1990.96.
    10.1038/hdy.1990.96
  87. BREHM, ANTONIO; KRIMBAS, COSTAS B.. "The phylogeny of nine species of the Drosophila obscura group inferred by the banding homologies of chromosomal regions. II. Element E.". Hereditas 113 2 (1990): 157-168. http://dx.doi.org/10.1111/j.1601-5223.1990.tb00080.x.
    10.1111/j.1601-5223.1990.tb00080.x
Capítulo de livro
  1. Mendonça, Maria Isabel; Palma dos Reis, Roberto; Brehm, António. "Prediction of Coronary Heart Disease Risk in a South European Population: a case-control study". Portugal: InTechOpen, 2012.
Livro
  1. Brehm, Antonio. Os Casamentos do Rei Os projectos matrimoniais para Dom Sebastião. Lisboa, Portugal: Edições Afrontamento. 2024.
    Publicado
  2. Brehm, Antonio ; Paolinelli, Luísa M. Antunes. Portugal na Encruzilhada da Europa Relação anónima de um gentil-homem da embaixada de Antonio Tiepolo às cortes ibéricas, 1571-72. Lisboa, Porto Rico: Edições Esgotadas. 2020.
    No prelo
  3. Brehm, Antonio ; Trindade, Ana Cristina; Carita, Rui. Cronica de El-Rei Dom Sebastião. Funchal, Portugal: Imprensa Académica. 2018.
    Publicado
Tese / Dissertação
  1. Cruz, Catarina Jeppesen. "História concisa das linhagens de DNA mitocondrial de uma população de judeus curdos através da análise da sua região controlo". Mestrado, 2016. http://hdl.handle.net/10400.13/1248.
  2. Berenguer, Anabela Gonçalves. "Asthma Polymorphic Loci genotyping in Madeira population: identification of potential genetic markers of disease susceptibility, severity and clinical relevance". Doutoramento, 2013. http://hdl.handle.net/10400.13/826.
  3. Conceição, Sara Catarina Reis Gomes da, 1978-. "Caracterização do ADN mitocondrial no estudo caso-controlo da infertilidade masculina". Mestrado, 2008. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000571730.

Outros

Outra produção
  1. Prevalence of H63D, S65C, and C282Y hereditary hemochromatosis gene variants in Madeira Island (Portugal). Hereditary HFE Hemochromatosis is an inherited disorder of iron metabolism that results from mutations in the HFE gene. Almost all patients with hereditary hemochromatosis show a C282Y mutation in homozygosity or in compound heterozygosity with H63D. Also, the mutation S65C has been shown to be associated to a milder iron overload. Since allele and genotype frequencies of these three variants of t. 2011. Spínola, Carla; Brehm, António; Spínola, Hélder. http://hdl.handle.net/10400.13/2149.
  2. Evaluation of two methods for computational HLA haplotypes inference using a real dataset. 2008. Bettencourt, Bruno F.; Santos, Margarida R.; Fialho, Raquel N.; Couto, Ana R.; Peixoto, Maria J.; Pinheiro, João P.; Spínola, Hélder; et al. http://hdl.handle.net/10400.13/1354.
    dx.doi.org/10.1186/1471-2015-9-68
  3. RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population. Background: Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 of these polymorphisms in order to find any association with CAD development and distinguish if any of the biochemical and behavioural factors interact with genetic polymorphisms in. 2008. Freitas, Ana I.; Mendonça, Isabel; Brión, Maria; Sequeira, Miguel M.; Reis, Roberto P.; Carracedo, Angel; Brehm, António; et al. http://www.scopus.com/inward/record.url?scp=48549092081&partnerID=8YFLogxK.
    https://doi.org/10.1186/1471-2261-8-15
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