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Identificação

Identificação pessoal

Nome completo
José Miguel Antunes Codêsso

Nomes de citação

  • Codêsso, José Miguel

Identificadores de autor

Ciência ID
9D1C-5F50-904E

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2020 - 2024
Em curso
 Biomedical Sciences [PhD] (Doutoramento)
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
"Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics" (TESE/DISSERTAÇÃO)
2012 - 2015
Concluído
 Biochemistry [MSc] (Mestrado)
University of Coimbra, Faculty of Sciences and Technology, Department of Life Sciences, Portugal
"Evaluation of the safety of a therapeutic strategy for Machado-Joseph Disease - Silencing human mutant ataxin-3 using a target-specific shRNA encoded by a directly brain-delivered lentiviral vector" (TESE/DISSERTAÇÃO)
 17
2014
Concluído
 Laboratory Animal Sciences (FELASA Category B) (Diploma de especialização)
Portuguese Society of Laboratory Animal Sciences , Portugal

University of Coimbra, Center for Neuroscience and Cell Biology, Portugal
Approved / Accredited
2007 - 2012
Concluído
 Biochemistry [BSc] (Licenciatura)
University of Coimbra, Faculty of Sciences and Technology, Department of Life Sciences, Portugal
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020 - Atual Investigador (Investigação) University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal
2020 - Atual Investigador (Investigação) University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
2015 - 2018 Estagiário de Investigação (Investigação) University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
Projetos

Bolsa

Designação Financiadores
2020 - Atual Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases
#22424
Bolseiro de Doutoramento
University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal
 The French Muscular Dystrophy Association
2020 - Atual Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics
SFRH/BD/148760/2019
Bolseiro de Doutoramento
University of Algarve, Center for Biomedical Research, Molecular Neuroscience and Gene Therapy Laboratory, Portugal

University of Coimbra, Center for Neuroscience and Cell Biology, Vectors and Gene Therapy Group, Molecular Therapy of Brain Disorders Laboratory, Portugal
Foundation for Science and Technology
Produções

Publicações

Artigo em revista
  1. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain (2022): http://dx.doi.org/10.1093/brain/awac473.
    Acesso aberto • 10.1093/brain/awac473
  2. Vasconcelos-Ferreira, Ana; Carmo-Silva, Sara; Codêsso, José Miguel; Silva, Patrick; Martinez, Alberto Rolim Muro; França Jr, Marcondes Cavalcante; Nóbrega, Clévio; Pereira de Almeida, Luís. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease". Neuropathology and Applied Neurobiology (2021): http://dx.doi.org/10.1111/nan.12763.
    10.1111/nan.12763
  3. Nóbrega, Clévio David Rodrigues*; Codêsso, José Miguel*; Mendonça, Liliana*; Pereira de Almeida, Luís. "RNA Interference Therapy for Machado–Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy 30 7 (2019): 841-854. http://dx.doi.org/10.1089/hum.2018.157.
    10.1089/hum.2018.157
Capítulo de livro
  1. Codêsso, José Miguel; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications. IntechOpen, 2023.
    10.5772/intechopen.109261
Poster em conferência
  1. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Translational regulation: exploring the impact of TRMT2A in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Trabalho apresentado em 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  2. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Silencing Trmt2a as a novel therapeutic target in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  3. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Modulation of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  4. Couto, Filipa Lopes; Codêsso, José Miguel; Paulino, Rodrigo; Nóbrega, Clévio David Rodrigues. "Overexpression of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2". Trabalho apresentado em 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  5. Codêsso, José Miguel; Brito, David V.C.; Mendonça, Liliana; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Unraveling the role of the RBP HSPA8 in Spinocerebellar Ataxia type 3: from pathogenesis to therapeutics". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  6. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "A expressão da proteína G3BP1 reduz as anomalias neuropatológicas e motoras em modelos da ataxia espinocerebelosa tipo 3". Trabalho apresentado em Portuguese Society of Movement Diseases Meeting 2022, 2022.
  7. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "RBP-X protein mitigates disease-associated pathology in different polyglutamine diseases". Trabalho apresentado em 1st Virtual Conference at European Society for Neurochemestry, 2021.
  8. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "RBP-X protein mitigates motor deficits in differents mice models of polyglutamine diseases". Trabalho apresentado em 51st Annual Meeting of the Portuguese Society of Pharmacology, 2021.
  9. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  10. Afonso-Reis, Ricardo; Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "Assessing the Role of Different G3BP1 Regions in the Mitigation of the Pathological Phenotype in SCA2 and SCA3 Disease Models". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  11. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models". Trabalho apresentado em IV Jornadas Algarve Biomedical Center, 2021.
  12. Afonso-Reis, Ricardo; Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models". Trabalho apresentado em IV Jornadas Algarve Biomedical Center, 2021.
  13. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020.
Resumo em conferência
  1. Conceição, André; Koppenol, Rebekah; Silva, Joana; Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Codêsso, José Miguel; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society for Human Genetics, Lisbon, 2021.
    Publicado
Tese / Dissertação
  1. Codêsso, José. "Evaluation of the safety of a therapeutic strategy for Machado-Joseph Disease - Silencing human mutant ataxin-3 using a target-specific shRNA encoded by a directly brain-delivered lentiviral vector". Mestrado, 2015.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023 Targeting transcriptional dysregulation in Machado-Joseph disease: silencing Trmt2a as a novel therapeutic target 4th International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics
(Covilhã, Portugal)
2023 Overexpression of the RNA binding protein HSPA8 in Spinocerebellar Ataxia type 2 9th European Neuroscience Conference by Doctoral Students (ENCODS)
(Faro, Portugal)
2021 RBP-X protein mitigates disease traits in different mice models of polyglutamine diseases 51st Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2021 Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models 51st Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2021 G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models IV Jornadas Algarve Biomedical Center
(Moura, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - 2021 RBP Modulation as a Therapeutic Strategy for Spinocerebellar Ataxia Type 3
Coorientador de Maria de Mendonça Sabbo
 Biomedical Sciences (Iniciação científica)
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023 - 2023 Volunteer work at Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023) (2023)
Conferência
 Algarve Biomedical Center - Research Institute, Portugal

University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023 - 2023 Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023)
Conferência
Algarve Biomedical Center - Research Institute, Portugal

University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2022 - 2022 ABC-RI International Forum (Spring Edition 2022) - Gene and Cell Therapies for Healthy Ageing
Encontro
Algarve Biomedical Center - Research Institute, Portugal
2021 - 2021 Course 'Models of the Blood-Brain Barrier - Scientific Tools to Target the Brain'
Outro
University of Lisbon, Faculty of Pharmacy, Portugal
2021 - 2021 Course 'Optical Microscopy Imaging for Biosciences'
Outro
University of Porto, Institute for Research and Innovation in Health, Portugal
2021 - 2021 Advanced Therapies 2021
Congresso
Terrapinn Holdings Ltd, Reino Unido
2021 - 2021 The CRISPR Revolution - a workshop on gene editing, from cells to animal models
Oficina (workshop)
University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2021 - 2021 CRISPR 2021
Conferência
Institut Pasteur, França
2021 - 2021 ABC-RI International Forum (Fall Edition 2021) - Neuroscience in Health and Disease
Encontro
Algarve Biomedical Center - Research Institute, Portugal
2021 - 2021 Course 'Stem Cell Technologies'
Outro
University of Lisbon, Faculty of Pharmacy, Portugal

Champalimaud Foundation, Portugal
2021 - 2021 Annual mRNA Day 21
Encontro
TriLink BioTechnologies Inc, Estados Unidos

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022 - 2022 Gene and Cell Therapy (seminars) - Cytotoxicity of RNA interference-mediated gene silencing Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2020 - 2022 Gene and Cell Therapy (practical classes) - Activating Autophagy as a Therapeutic Strategy for Huntington's Disease in a Cellular Model (assistant teacher) Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal
2021 - 2021 Animal Models in Biomedical Research (practical session & bioterium (animal facility) visit) - Methods for Animal Behavior Research Biomedical Sciences (Licenciatura) University of Algarve, Faculty of Medicine and Biomedical Sciences, Portugal

Tutoria

Tópico Nome do aluno
2022 - 2023 Modulation of an RBP as Potential Therapeutic Strategy for Spinocerebellar Ataxia Type 2 - Thesis / Dissertation [Biomedical Sciences (Master)] - University of Algarve, Faculty of Medicine and Biomedical Sciences Filipa Lopes Couto
2022 - 2022 Mouse Behaviour Experiments for the Evaluation of a Potential Theraphy for SCA3 - Optional Laboratorial Internships [Biomedical Sciences (Master)] - University of Algarve, Faculty of Medicine and Biomedical Sciences Maria de Mendonça Sabbo
Distinções

Outra distinção

2019 PhD fellowship, FCT reference: SFRH/BD/148760/2019