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Ana Sofia Marques (ASM) completed her bachelor degree in Biotechnology in 2020 at University of Aveiro (UAVR). Her bachelor’s final project, entitled “Optimization of L-Asparaginase production by Bacillus subtilis”, was carried out at the Aveiro Institute of Materials (CICECO, UAVR). During this period, she had the opportunity to acquire scientific and technical knowledge in the production of enzymes by bacteria through fermentation and collaborated in writing a review article on L-asparaginase recombinant production processes (https://doi.org/10.1007/s00253-021-11359-y). Afterwards, she did a summer internship at Lusogenes company (Aveiro, Portugal) where she learned about genetic improvement using reproductive biotechnologies (artificial insemination and sperm preservation/cryopreservation). By the end of 2022, she completed her master degree in biotechnology, with specialization in Molecular Biotechnology and Bioengineering, at the same institution. During the first academic year of her Master, ASM carried out volunteer research activities at CICECO in a project related to studying the effect of deep eutectic solvents in the stability of immunoglobulin G antibodies, that resulted in the publication of one scientific article (http://dx.doi.org/10.1039/d2gc03415h). At the end of the first year of her master, she did a second summer internship at NeuroSoV (Covilhã, Portugal), where she had the opportunity to follow some in vivo studies and immunohistochemistry assays for developing a new molecule for Parkinson’s Disease. ASM then developed (CICECO, UAVR) her MSc thesis entitled “Purification and stability of antibodies using alternative materials and solvents”. During this period, she had the opportunity to acquire and consolidate scientific and technical skills in protein analysis methodologies (e.g., SE-HPLC and SDS-PAGE). Up to date, she is co-author of two scientific articles, one of them in the high impact journal Green Chemistry. During her academic path, ASM had the opportunity to disseminate the results of her research in two conferences and has participated in several workshops and webinars to expand her knowledge in different scientific domains. Recently, she won the competition for the best logo and it was chosen as the official logo for the UAVR-RNA Club and she was awarded with an one-year trainee membership in the RNA Society. After this period she was a Research Fellow at CICECO (UAVR), hired under the framework of a European Innovation Council-funded project (Yscript-Ref. 101047214). Her work focused the stabilization and extraction of bioproduced mRNA using biocompatible ionic liquids. In this context, she spent 3 months as a visiting researcher at the CBM-CNRS (Orléans, France). Currently, she is a PhD student, at the same research group, and her present research activities involve integrated separation-purification strategies of nucleic acids produced from recombinant technology.
Identificação

Identificação pessoal

Nome completo
Ana Sofia Correia Marques

Nomes de citação

  • Ana S. C. Marques

Identificadores de autor

Ciência ID
A210-32D8-10DA
ORCID iD
0000-0001-5798-0917

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial
  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B2)
Formação
Grau Classificação
2023/10/01 - 2027/09/30
Em curso
Engenharia Química (Doutoramento)
Universidade de Aveiro, Portugal
2020 - 2022
Concluído
Biotecnologia (Mestrado)
Especialização em Molecular Biotechnology and Bioengineering
Universidade de Aveiro, Portugal
"Purification and stability of antibodies using alternative materials and solvents " (TESE/DISSERTAÇÃO)
17
2017 - 2020
Concluído
Biotecnologia (Licenciatura)
Universidade de Aveiro, Portugal
"Optimization of L-Asparaginase production by bacillus subtilis" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2023/10/01 - Atual PhD Student Fundação para a Ciência e a Tecnologia, Portugal
2022/10/01 - 2023/09/30 Research Grant Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro, Portugal
2023/01 - 2023/03 Visiting PhD Student Centre National de la Recherche Scientifique, França
Centre de Biophysique Moléculaire, França
2020 - 2022 Volunteer researcher Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro, Portugal
2021/07 - 2021/08 Summer Internship - NeuroSov NeuroSov , Portugal
Universidade da Beira Interior, Portugal
2020/07 - 2020/09 Summer Internship - Lusogenes Lusogenes , Portugal
Projetos

Projeto

Designação Financiadores
2022/10/01 - 2023/10/01 Yscript- Yeast cell factory for mRNA bioproduction
BI/UI89/10423/2022
Bolseiro de Investigação
Universidade de Aveiro CICECO, Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Diksha Dhiman; Ana S. C. Marques; Meena Bisht; Ana P. M. Tavares; Mara G. Freire; Pannuru Venkatesu. "Unveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies". Green Chemistry (2022): http://dx.doi.org/10.1039/d2gc03415h.
    10.1039/d2gc03415h
  2. Daniel Castro; Ana Sofia C. Marques; Mafalda R. Almeida; Gabriela B. de Paiva; Heitor B. S. Bento; Danielle B. Pedrolli; Mara G. Freire; Ana P. M. Tavares; Valéria C. Santos-Ebinuma. "L-asparaginase production review: bioprocess design and biochemical characteristics". Applied Microbiology and Biotechnology 105 11 (2021): 4515-4534. https://doi.org/10.1007/s00253-021-11359-y.
    10.1007/s00253-021-11359-y
Poster em conferência
  1. Ana S. C. Marques; João L. P. Fernandes; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Autor correspondente: Ana S. C. Marques. "Recovery of recombinant nucleic acid-based biopharmaceuticals using alternative solvents". Trabalho apresentado em 6th Meeting of Medicinal Biotechnology, 2024.
  2. Ana S. C. Marques; João L. P. Fernandes; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Ana Poim; Ana R. Soares; Chantal Pichon; Mara G. Freire. Autor correspondente: Ana S. C. Marques. "Integrated extraction-preservation platforms of nucleic acid-based biopharmaceuticals using alternative solvents". Trabalho apresentado em VII iBiMED Symposium, 2024.
  3. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. "Ionic Liquids: An innovative cell disruption method for the extraction of nucleic acids-based biopharmaceuticals from yeast". Trabalho apresentado em MICROBIOTEC 2023 - Congress of Microbiology and Biotechnology, 2023.
  4. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Autor correspondente: Ana S. C. Marques. "Innovative use of Ionic Liquids for Extracting Nucleic Acid-Based Biopharmaceuticals from Yeast". Trabalho apresentado em Jornadas do CICECO 2023, 2023.
  5. Ana S. C. Marques; Augusto Q. Pedro; Cristine Gonçalves; Ana P. M. Tavares; Chantal Pichon; Mara G. Freire. Autor correspondente: Ana S. C. Marques. "Development of an integrated process for the recovery and purification of recombinant messenger RNA vaccines resorting to bio-based ionic liquids". Trabalho apresentado em ChemPor 2023 – International Chemical and Biological Engineering Conference, 2023.
  6. Ana S. C. Marques; Diksha Dhiman; Meena Bisht; Ana P. M. Tavares; Mara G. Freire; Pannuru Venkatesu. Autor correspondente: Ana S. C. Marques. "Potential of deep eutectic solvents to improve the conformational and colloidal stability of biopharmaceuticals". Trabalho apresentado em SPQ 2023- XXVIII Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  7. Ana S. C. Marques; MÁRIO R. C. SOROMENHO; ANA P. M. TAVARES; MARA G. FREIRE; JOSÉ M. S. S. ESPERANÇA. "Purification of antibodies using alternative materials". Trabalho apresentado em 5th Meeting of Medicinal Biotechology, 2022.
  8. ANA S. C. MARQUES; MÁRIO R. C. SOROMENHO; ANA P. M. TAVARES; MARA G. FREIRE; JOSÉ M. S. S. ESPERANÇA. "Purification of antibodies using alternative materials". Trabalho apresentado em Jornadas CICECO 2022, 2022.
Tese / Dissertação
  1. "Purification and stability of antibodies using alternative materials and solvents". Mestrado, 2022.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10 Exploring novel solvents for enhanced conformational and colloidal stability of biopharmaceuticals. XXVII Encontro Luso-Galego de Química
(Porto, Portugal)
2023/08 Extraction strategies for developing recombinant messenger RNA vaccines resorting to biobased ionic liquids. Research Summit
Universidade de Aveiro (Aveiro, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2024/06/19 - 2024/06/19 AIM Further- "Where will the future take me? Academia vs Insdustry" (2024/08/19 - 2024/08/19)
Encontro (Coorganizador)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2022/10/21 - Atual Participation in the 5th Meeting of Medicinal Biotechnology 5th Meeting of Medicinal Biotechnology
2023/03/22 - 2023/03/23 Attendance to the meeting "Yeast cell factory for mRNA bioproduction - Kick-off Meeting"
Universidade de Aveiro, Portugal
2022/12/16 - 2022/12/16 Attendance to the webinar entitle "Sexagem de sémen: Aplicações na Produção Animal"
2022/10/19 - 2022/10/19 Attendance at the workshop entitled "Modern Data Exploration and Design of Experiments"
2022/10/12 - 2022/10/12 Participation in the Jornadas CICECO 2022 Jornadas CICECO 2022
Universidade de Aveiro CICECO, Portugal
2022/06/02 - 2022/06/02 Attendance to PATh/IL2BioPro/mVACCIL Workshop: Leading strategies in biopharmaceuticals manufacturing
2021/09/30 - 2021/09/30 Attendance to 6th PATh Spring Workshop: A Path Towards Biomass Valorization Assisted by Green Chemistry Tools

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2023/10/01 - Atual PhD Student Committee (CAD) at CICECO - Aveiro Institute of Materials, University of Aveiro
Membro
Universidade de Aveiro CICECO, Portugal
Distinções

Prémio

2023 Official logo for UAVR-RNAClub - RNA Society 1-year membership
Universidade de Aveiro, Portugal