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David Suter is currently a Swiss National Science Foundation Professor and Tenure Track Assistant Professor at the EPFL (École Polytechnique Fédérale de Lausanne). Research at the Suter lab is focused on understanding how temporal fluctuations in gene expression and the interplay between transcription factors and the cell cycle impact cell fate decisions. To tackle these problems, the Suter team has developed quantitative approaches to characterize in individual cells the dynamics of gene expression and interaction of transcription factors with chromatin, based on genome-editing and diverse imaging methods.
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Identification

Personal identification

Full name
David Suter

Citation names

  • Suter, David

Author identifiers

Ciência ID
0619-9AAF-E71D
ORCID iD
0000-0001-5644-4899

Email addresses

  • david.suter@epfl.ch (Professional)

Telephones

Telephone
  • (+41) 21 693 96 (Professional)

Addresses

  • EPFL-SV-IBI Station 15 - Suter Lab, CH-1015, Lausanne, Lausanne, Switzerland (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
German Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2003 - 2007
Concluded
 Neuronal differentiation of embryonic stem cells (Doctor of Philosophy)
Universite de Geneve, Switzerland
1997 - 2003
Concluded
 Medicine (Bachelor)
Universite de Geneve, Switzerland
Affiliation

Science

Category
Host institution 		Employer
2013 - Current Principal Investigator (Research) École Polytechnique Fédérale de Lausanne Institut de Bioingénierie, Switzerland
2011/05 - 2013/04 Postdoc (Research) Harvard University Department of Molecular and Cellular Biology, United States
2008/04 - 2011/03 Postdoc (Research) Universite de Geneve, Switzerland
2007/10 - 2008/03 Postdoc (Research) Universite de Geneve, Switzerland

Teaching in Higher Education

Category
Host institution 		Employer
2021/01/01 - Current Associate Professor (University Teacher) École Polytechnique Fédérale de Lausanne Institut de Bioingénierie, Switzerland
2013 - 2020/12/31 Assistant Professor (University Teacher) École Polytechnique Fédérale de Lausanne Institut de Bioingénierie, Switzerland
Outputs

Publications

Journal article
  1. David M. Suter. "Transcription Factors and DNA Play Hide and Seek". Trends in Cell Biology (2020): https://doi.org/10.1016/j.tcb.2020.03.003.
    10.1016/j.tcb.2020.03.003
  2. Elias T Friman; Cédric Deluz; Antonio CA Meireles-Filho; Subashika Govindan; Vincent Gardeux; Bart Deplancke; David M Suter. "Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle". eLife (2019): https://doi.org/10.7554/eLife.50087.
    10.7554/eLife.50087
  3. Nicholas E. Phillips; Aleksandra Mandic; Saeed Omidi; Felix Naef; David M. Suter. "Memory and relatedness of transcriptional activity in mammalian cell lineages". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-019-09189-8.
    10.1038/s41467-019-09189-8
  4. Onur Tidin; Elias T. Friman; Felix Naef; David M. Suter. "Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-019-41870-2.
    10.1038/s41598-019-41870-2
  5. Daniel Strebinger; Cédric Deluz; Elias T Friman; Subashika Govindan; Andrea B Alber; David M Suter. "Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions". Molecular Systems Biology 15 9 (2019): https://doi.org/10.15252/msb.20199002.
    10.15252/msb.20199002
  6. Suter, David. "Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle". bioRxiv (2019): http://dx.doi.org/10.1101/698571.
    10.1101/698571
  7. Andrea Callegari; Christine A. Wells; Christian Sieben; Alexander Benke; David M. Suter; Beat Fierz; Davide Mazza; Suliana Manley. "Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation". PLOS Genetics 15 1 (2019): e1007891-e1007891. https://doi.org/10.1371/journal.pgen.1007891.
    10.1371/journal.pgen.1007891
  8. Suter, David. "Mitotic chromosome binding predicts transcription factor properties in interphase". Nature Communications (2018): https://www.nature.com/articles/s41467-019-08417-5.
  9. Mahé Raccaud; David M. Suter. "Transcription factor retention on mitotic chromosomes: regulatory mechanisms and impact on cell fate decisions". FEBS Letters (2018): https://doi.org/10.1002/1873-3468.12828.
    10.1002/1873-3468.12828
  10. Suter, David. "Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture.". (2018):
  11. Suter, David. "Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells.". Cell chemical biology (2017): http://europepmc.org/abstract/med/29174541.
    10.1016/j.chembiol.2017.10.008
  12. Deluz C; Strebinger D; Friman ET; Suter DM. "The elusive role of mitotic bookmarking in transcriptional regulation: insights from Sox2.". (2017): http://europepmc.org/abstract/med/28166426.
    10.1080/15384101.2017.1288332
  13. Deluz C; Friman ET; Strebinger D; Benke A; Raccaud M; Callegari A; Leleu M; Manley S; Suter DM. "A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.". (2016): http://europepmc.org/abstract/med/27920086.
    10.1101/gad.289256.116
  14. Zhao ZW; Roy R; Gebhardt JC; Suter DM; Chapman AR; Xie XS. "Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy.". (2014): http://europepmc.org/abstract/med/24379392.
    10.1073/pnas.1318496111
  15. Molina N; Suter DM; Cannavo R; Zoller B; Gotic I; Naef F. "Stimulus-induced modulation of transcriptional bursting in a single mammalian gene.". (2013): http://europepmc.org/abstract/med/24297917.
    10.1073/pnas.1312310110
  16. Zhao ZW; Gebhardt JC; Suter DM; Xie XS. "Reply to "Convergence of chromatin binding estimates in live cells".". (2013): http://europepmc.org/abstract/med/23900249.
    10.1038/nmeth.2574
  17. Gebhardt JC; Suter DM; Roy R; Zhao ZW; Chapman AR; Basu S; Maniatis T; Xie XS. "Single-molecule imaging of transcription factor binding to DNA in live mammalian cells.". (2013): http://europepmc.org/abstract/med/23524394.
    10.1038/nmeth.2411
  18. Kern I; Xu R; Julien S; Suter DM; Preynat-Seauve O; Baquié M; Poncet A; et al. "Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells.". (2013): http://europepmc.org/abstract/med/23231350.
    10.2174/092986713804999330
  19. Stratmann M; Suter DM; Molina N; Naef F; Schibler U. "Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.". (2012): http://europepmc.org/abstract/med/22981862.
    10.1016/j.molcel.2012.08.012
  20. Suter DM; Molina N; Naef F; Schibler U. "Origins and consequences of transcriptional discontinuity.". (2011): http://europepmc.org/abstract/med/21963300.
    10.1016/j.ceb.2011.09.004
  21. Clément S; Peyrou M; Sanchez-Pareja A; Bourgoin L; Ramadori P; Suter D; Vinciguerra M; et al. "Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.". (2011): http://europepmc.org/abstract/med/21465511.
    10.1002/hep.24340
  22. Suter DM; Molina N; Gatfield D; Schneider K; Schibler U; Naef F. "Mammalian genes are transcribed with widely different bursting kinetics.". (2011): http://europepmc.org/abstract/med/21415320.
    10.1126/science.1198817
  23. Saini C; Suter DM; Liani A; Gos P; Schibler U. "The mammalian circadian timing system: synchronization of peripheral clocks.". (2011): http://europepmc.org/abstract/med/22179985.
    10.1101/sqb.2011.76.010918
  24. Suter DM; Schibler U. "Physiology. Feeding the clock.". (2009): http://europepmc.org/abstract/med/19833950.
    10.1126/science.1181278
  25. Suter DM; Preynat-Seauve O; Tirefort D; Feki A; Krause KH. "Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells.". (2009): http://europepmc.org/abstract/med/20196783.
    10.1111/j.1582-4934.2009.00660.x
  26. Preynat-Seauve O; Suter DM; Tirefort D; Turchi L; Virolle T; Chneiweiss H; Foti M; et al. "Development of human nervous tissue upon differentiation of embryonic stem cells in three-dimensional culture.". (2009): http://europepmc.org/abstract/med/19074418.
    10.1634/stemcells.2008-0600
  27. Suter DM; Tirefort D; Julien S; Krause KH. "A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells.". (2009): http://europepmc.org/abstract/med/18832594.
    10.1634/stemcells.2008-0319
  28. Suter DM; Krause KH. "Neural commitment of embryonic stem cells: molecules, pathways and potential for cell therapy.". (2008): http://europepmc.org/abstract/med/18566959.
    10.1002/path.2380
  29. Aberdam E; Barak E; Rouleau M; de LaForest S; Berrih-Aknin S; Suter DM; Krause KH; et al. "A pure population of ectodermal cells derived from human embryonic stem cells.". (2008): http://europepmc.org/abstract/med/18032703.
    10.1634/stemcells.2007-0588
  30. Radcliffe CM; Arnold JN; Suter DM; Wormald MR; Harvey DJ; Royle L; Mimura Y; et al. "Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.". (2007): http://europepmc.org/abstract/med/17197448.
    10.1074/jbc.M602690200
  31. Suter DM; Dubois-Dauphin M; Krause KH. "Genetic engineering of embryonic stem cells.". (2006): http://europepmc.org/abstract/med/16897894.
  32. Suter DM; Cartier L; Bettiol E; Tirefort D; Jaconi ME; Dubois-Dauphin M; Krause KH. "Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors.". (2006): http://europepmc.org/abstract/med/16293575.
    10.1634/stemcells.2005-0226
  33. Arnold JN; Wormald MR; Suter DM; Radcliffe CM; Harvey DJ; Dwek RA; Rudd PM; Sim RB. "Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.". (2005): http://europepmc.org/abstract/med/15955802.
    10.1074/jbc.M504528200

Intellectual property

Patent
  1. Suter, David. 2013. "Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative". United States.
    Allowed

Other

Other output
  1. Gene-specific transcriptional memory in mammalian cell lineages. 2018. Nicholas E. Phillips; Aleksandra Mandic; Saeed Omidi; Felix Naef; David M. Suter. https://doi.org/10.1101/411447.
    10.1101/411447
  2. Mitotic chromosome binding predicts transcription factor properties in interphase. 2018. Mahé Raccaud; Andrea B. Alber; Elias T. Friman; Harsha Agarwal; Cédric Deluz; Timo Kuhn; J. Christof M. Gebhardt; David M. Suter. https://doi.org/10.1101/404723.
    10.1101/404723
  3. Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions. 2018. Daniel Strebinger; Cédric Deluz; Elias T. Friman; Subashika Govindan; Andrea B. Alber; David M. Suter. https://doi.org/10.1101/299073.
    10.1101/299073
  4. Single-molecule dynamics and genome-wide transcriptomics reveal that NF-¿B (p65)-DNA binding times can be decoupled from transcriptional activation. 2018. Andrea Callegari; Christian Sieben; Alexander Benke; David M. Suter; Beat Fierz; Davide Mazza; Suliana Manley. https://doi.org/10.1101/255380.
    10.1101/255380
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - Current In vitro and in vivo study of molecular mechanism of the interaction between DNA and transcription factors in cell fate decision control
Supervisor of Sim Sakong
2015 - 2019 The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells
Supervisor of Elias Friman
2015 - 2019 Mitotic chromosome binding predicts transcription factor properties in interphase
Supervisor of Mahé Raccaud
2014 - 2018 Quantitative single cell dynamics of signaling and transcriptional response in mammalian cells
Supervisor of Onur Tidin
2014 - 2018 Quantitative analysis of gene expression and transcriptional memory in mouse embryonic stem cells
Supervisor of Aleksandra Mandic
2014 - 2018 Quantitative analysis of SOX2 and OCT4 expression in pluripotency and differentiation
Supervisor
2013 - 2018 Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates
Supervisor of Andrea Alber

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018 - Current Mentorship in the “Fix the leaky pipeline” aiming at promoting women’s careers in science
École Polytechnique Fédérale de Lausanne, Switzerland

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/12/09 Transcription Factor-Dependent Regulation of Neural Stem Cell Identity Throughout Mitosis
(Thesis) Main arguer
 Mário A.F. Soares (PhD)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019 - Current Board member of the EDCB doctoral program
2019 - Current Member of the Animal Research Ethics Committee (AREC) of EPFL École Polytechnique Fédérale de Lausanne, Switzerland
2016 - Current President of the gender committee of the School of Life Sciences École Polytechnique Fédérale de Lausanne, Switzerland
2015 - Current Board Member of the Swiss Stem Cell Network
2015 - Current Member of the EPFL Teachers Council (CCE)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - Current Cellular and Molecular Biology (Bachelor) École Polytechnique Fédérale de Lausanne, Switzerland
2016 - Current Single Cell Genomics (Master) École Polytechnique Fédérale de Lausanne, Switzerland
2014 - Current Stem cell Biology and Technology (Master) École Polytechnique Fédérale de Lausanne, Switzerland
2013 - 2018 Introduction to life sciences (Bachelor (1st cycle)) École Polytechnique Fédérale de Lausanne, Switzerland

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018 - Current HFSP Junior Grants
2017 - Current Dutch Research Council (NWO)
2016 - Current Agence Nationale de la Recherche
2016 - Current Austrian Science Fund (FWF)
2016 - Current post-doctoral fellowships of the Swiss National Science Foundation
2015 - Current Biotechnology and Biological Sciences Research Council
2014 - Current Part of the prize committee that awards "Future leaders in bioengineering award”

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Disease Models & Mechanisms - ad hoc reviewer (1754-8411) The Company of Biologists
2018 - Current Nature Reviews Molecular Cell Biology - ad hoc reviewer (1471-0080) Springer Science and Business Media LLC
2017 - Current Science - ad hoc reviewer
2017 - Current The EMBO Journal - ad hoc reviewer (1460-2075) EMBO
2017 - Current Genome Biology - ad hoc reviewer (1465-6906) Springer (Biomed Central Ltd.)
2016 - Current Nature Cell Biology - ad hoc reviewer (1476-4679) Springer Science and Business Media LLC
2016 - Current eLife - ad hoc reviewer (2050-084X) "eLife Sciences Publications, Ltd."
2016 - Current Nucleic Acids Research - ad hoc reviewer (1362-4962) Oxford University Press
2016 - Current Cell Reports - ad hoc reviewer (2211-1247) Elsevier
2016 - Current EMBO Reports - ad hoc reviewer (1469-3178) EMBO
2014 - Current Cell stem cell - ad hoc reviewer
Distinctions

Award

2011 Advanced Researcher fellowship from the Swiss National Science Foundation
2008 Faculty prize for the best thesis in cell biology
2004 MD/PhD fellowship from the Swiss National Science Foundation

Title

2013 Swiss National Science Foundation professorship
École Polytechnique Fédérale de Lausanne, Switzerland