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Ana Veiga Caulino Rocha. Completed the Mestrado in Medicina Legal in 2019 by Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar and Licenciatura in Ciências Bioanalíticas in 2017 by Universidade de Coimbra Faculdade de Farmácia. Attends the Doutoramento in Ciências Farmacêuticas by Universidade de Coimbra Faculdade de Farmácia since 2023. Is Research Trainee in Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia and Research Trainee in iNOVA4Health. Published 6 articles in journals. Organized 6 event(s). Participated in 4 event(s). Has received 4 awards and/or honors. Participates and/or participated as Research Technician Fellow in 1 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pharmacology and pharmacy and Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pathology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Ciências da saúde; Health sciences; Ciências médicas e da saúde::Ciências da saúde; Methylprednisolone; Glucocorticoid receptors; Mineralocorticoid receptors; Synchronous GABA and Glutamate release; Hippocampal nerve terminals; cannabinoids; cannabidiol; isolated nerve terminals; GABA; glutamate; VIP (vasoactive intestinal peptide); Interneurons; Hippocampus; Synaptic transmission and GABA; synaptic plasticity (LPT/LTD); mesial temporal lobo epilepsy (MTLE); epileptogenesis; learning and memory; inflammation; .
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Identification

Personal identification

Full name
Ana Veiga Caulino Rocha
Date of birth
1995/12/01
Gender
Female

Citation names

  • Caulino-Rocha, Ana

Author identifiers

Ciência ID
0916-863C-8374
ORCID iD
0000-0002-4051-5952
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=xHrOBNgAAAAJ
Scopus Author Id
57217380631

Email addresses

  • anacaulino@hotmail.com (Professional)

Telephones

Mobile phone
  • 968939556 (Personal)

Addresses

  • Quinta Sr. dos Matosinhos, 5120-262, Pereiro, Tabuaço, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023 - 2027
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020
Concluded
 Laboratory Animal Science course (Function A & D) (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
 19
2017 - 2019
Concluded
 Medicina Legal (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The effect of cannabidiol in the immature brain" (THESIS/DISSERTATION)
 18
2013 - 2017
Concluded
 Ciências Bioanalíticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 12
Affiliation

Science

Category
Host institution 		Employer
2023/11/01 - Current Research Trainee (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2023/11/01 - Current Research Trainee (Research) iNOVA4Health, Portugal
2022/02/01 - 2023/10/31 Contracted Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/10/01 - 2023/02/28 Visiting Researcher (Research) iNOVA4Health, Portugal
2019/09/01 - 2021/08/31 Research Assistant (Research) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09/12 - 2019/09/30 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Grant

Designation Funders
2019/10/01 - 2021/08/31 EPIRaft Contribution of neuronal membrane and lipid raft remodelling to the pathophysiology of mesial temporal lobe epilepsy (MTLE): insight into the beneficial effects of the ketogenic diet therapy
PTDC/SAU-PUB/28311/2017
Research Technician Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Ongoing

Contract

Designation Funders
2022/02/01 - 2023/10/31 Synaptic vesicle maturation and its relevance for neurodegeneration
SVmaturation –PTDC/MED-NEU/8030/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. Marta Bento; Caulino-Rocha, Ana; Joaquim Alexandre Ribeiro; Cunha-Reis, Diana. "A decrease in GluA1 basal phosphorylation levels may contribute to the enhancement in LTP induced by theta-burst stimulation along postweaning development". Paper presented in 11th IBRO World Congress of Neuroscience, Granada, 2023.
    Published
  2. Caulino-Rocha, Ana; Carlos Nascimento; Amaro-Leal, Ângela; Serpa, Andre; Cunha-Reis, Diana. "Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with synaptic remodeling and hippocampal monoamines. Epilepsia, 64(S2), 227-228 .". Paper presented in 35th International Epilepsy Congress, Dublin, 2023.
    Published
  3. Gil, Marta; Caulino-Rocha, Ana; Vila-Verde, Beatriz; Reis-Borges, Diana; Nascimento, Carlos; Cunha-Reis, Diana. "Altered synaptic physiology and impaired cognition, response to novelty and motor behaviour in a rodent model of accelerated aging". Paper presented in Neuronus 2022 Meeting published in Acta Neurobiologiae Experimentalis, Krakow, 2022.
    Published
  4. Caulino-Rocha, Ana; Fátima Aidil-Carvalho; Carolina Duque-Queiroz; Joaquim A Ribeiro; Cunha-Reis, Diana. "Influence of novelty exploration training on modulation of hippocampal synaptic plasticity by endogenous VIP acting on VPAC1 receptors". Paper presented in SFBis 2020 Published in Biomed Biopharm Res, 2020.
    Published • 10.1109/cne.2003.1196748
Conference paper
  1. Bento, Marta; Serpa, Andre; Caulino-Rocha, Ana; Seweryn Pawlak; Cunha-Reis, Diana. "VPAC1 and VPAC2 receptors are opposingly altered in the Li2+-pilocarpine model of temporal lobe epilepsy". Paper presented in 2nd International Meeting of the Portuguese Society of Physiology, Coimbra, 2022.
    In press
  2. Gil, Marta; Caulino-Rocha, Ana; Beatriz Vila-Verde; Diana Reis-Borges; Carlos Nascimento; Cunha-Reis, Diana. "Altered synaptic physiology and impaired cognition, response to novelty and motor behavior in a rodent model of accelerated aging". Paper presented in Neuronus 2022 Meeting, Krakow, 2022.
    Published
Conference poster
  1. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Modulation of E3-ubiquitin Ligase Fbxo32 Rescues Dopaminergic Axon Dysmorphology and the Ubiquitin system in Endophilin-A Mutants.". Paper presented in RESET meeting, 2023.
  2. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Reduction of FBXO32 rescues dopaminergic axonal pathology in Endophilin-A mutants". Paper presented in Champalimaud Research Symposium 23, 2023.
  3. Barata, Mariana Afonso; Perdigão, Catarina; Caulino-Rocha, Ana; Guimas Almeida, Claudia. "Late-onset Alzheimer¿s disease risk variants compromise Bin1 synaptic function". Paper presented in FENS Regional Meeting 2023 Algarve, 2023.
  4. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Endophilin-A mutants display age-dependent alterations in the dopaminergic system". Paper presented in FENS Regional Meeting 2023, 2023.
  5. Bento, Marta; Caulino-Rocha, Ana; Cunha-Reis, Diana. "Postweaning development influences synaptic VPAC1 and VPAC2 receptor expression and the expression and phosphorylation of AMPA GluA1 and GluA2 subunits". Paper presented in 2nd International Meeting of the Portuguese Society of Physiology, 2022.
  6. Caulino-Rocha, Ana; Nádia C. Rodrigues; Andreia Oliveira; Joaquim A Ribeiro; Cunha-Reis, Diana. "Molecular pathways involved in VIP inhibition of LTP in the CA1 area of the hippocampus". Paper presented in FENS 2020, 2020.
Journal article
  1. Fatima Aidil-Carvalho; Ana Caulino-Rocha; Joaquim Alexandre Ribeiro; Diana Cunha-Reis. "Mismatch novelty exploration training shifts VPAC1 receptor-mediated modulation of hippocampal synaptic plasticity by endogenous VIP in male rats". Journal of Neuroscience Research (2024): https://doi.org/10.1002/jnr.25333.
    10.1002/jnr.25333
  2. Serpa, Andre; Bento, Marta; Caulino-Rocha, Ana; Pawlak, Seweryn; Cunha-Reis, Diana. "Opposing reduced VPAC1 and enhanced VPAC2 VIP receptors in the hippocampus of the Li2+-pilocarpine rat model of temporal lobe epilepsy". Neurochemistry International 158 (2022): 105383. http://dx.doi.org/10.1016/j.neuint.2022.105383.
    Published • 10.1016/j.neuint.2022.105383
  3. Ana Caulino-Rocha; Nádia Carolina Rodrigues; Joaquim Alexandre Ribeiro; Diana Cunha-Reis. "Endogenous VIP VPAC1 Receptor Activation Modulates Hippocampal Theta Burst Induced LTP: Transduction Pathways and GABAergic Mechanisms". Biology (2022): https://doi.org/10.3390/biology11050627.
    10.3390/biology11050627
  4. N. C. Rodrigues; A. Silva-Cruz; A. Caulino-Rocha; A. Bento-Oliveira; J. A. Ribeiro; D. Cunha-Reis. "Hippocampal CA1 theta-burst induced LTP from weaning to adulthood: cellular and molecular mechanisms in young male rats revisited". European Journal of Neuroscience (2021): https://doi.org/10.1111/ejn.15390.
    10.1111/ejn.15390
  5. D. Cunha-Reis; A. Caulino-Rocha; P. Correia-de-Sá. "VIPergic neuroprotection in epileptogenesis: challenges and opportunities". Pharmacological Research (2020): 105356-105356. https://doi.org/10.1016/j.phrs.2020.105356.
    10.1016/j.phrs.2020.105356
  6. Cunha-Reis, Diana; Caulino-Rocha, Ana. "VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00153.
    10.3389/fncel.2020.00153
  7. Neiva, Rafael; Caulino-Rocha, Ana; Ferreirinha, F.; Graça Lobo; Correia-de-Sá, Paulo. "Non-genomic actions of methylprednisolone differentially influence GABA and glutamate release from isolated nerve terminals of the rat hippocampus". Frontiers in Molecular Neuroscience (2019):
    Published • 10.3389/fnmol.2020.00146
Preprint
  1. Carlos Nascimento; Vasco Guerreiro-Pinto; Seweryn Pawlak; Ana Caulino-Rocha; Laia Amat-Garcia; Diana Cunha-Reis. "Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with hippocampal monoaminergic inputs". 2024. https://doi.org/10.1101/2024.02.07.579299.
    10.1101/2024.02.07.579299
  2. Marta Gil; Ana Caulino-Rocha; Marta Bento; Nadia Carolina Rodrigues; Armando Silva-Cruz; Joaquim Alexandre Ribeiro; Diana Cunha-reis. "Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation: a link to maturation of the hippocampal GABAergic system?". 2024. https://doi.org/10.1101/2024.02.18.580862.
    10.1101/2024.02.18.580862
  3. F Aidil-Carvalho; A Caulino-Rocha; JA Ribeiro; D Cunha-Reis. "Mismatch novelty exploration training impairs VPAC1 receptor mediated modulation of hippocampal synaptic plasticity by endogenous VIP". 2022. https://doi.org/10.1101/2022.12.21.521348.
    10.1101/2022.12.21.521348
Thesis / Dissertation
  1. Ana Veiga Caulino Rocha. "The effect of cannabidiol in the immature brain". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2019. https://hdl.handle.net/10216/124614.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12 Modulation of E3-ubiquitin ligase Fbxo32 in Endophilin-A mutants rescues dopaminergic axonal pathology Pharma PhD day 2023
Faculdade de Farmácia Universidade de Coimbra (Coimbra, Portugal)
2022/02/11 Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation SPF Meeting 2022
Universidade do Porto (Porto, Portugal)
2022 VPAC1 and VPAC2 receptors are opposingly altered in the Li2+-pilocarpine model of temporal lobe epilepsy 2nd International Meeting of the Portuguese Society of Physiology
Portuguese Society of Physiology (Coimbra, Portugal)
2021/05 Neurochemical effects of cannabidiol on synchronous GABA and glutamate release from nerve terminals of immature vs. adult rats IJUP 2021
Universidade do Porto (Porto, Portugal)
2021/02/18 Cannabidiol preferentially affects GABA and Glutamate release from immature hippocampal nerve terminals SPF meeting 2021
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2020/02/13 Cannabidiol modulates basal and depolarized-evoked release of GABA and Glutamate from hippocampal nerve terminals from of immature and adult rats IJUP2020
Universidade do Porto (Porto, Portugal)
2020/02/06 Cannabidiol (CBD) differentially affects resting and depolarization-evoked [3H]GABA and [14C]Glutamate release from hippocampal nerve terminals of immature and adult rats SPF Meeting 2020
Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2020 Influence of novelty exploration training on modulation of hippocampal synaptic plasticity by endogenous VIP acting on VPAC1 receptors SFBis 2020
Sociedade Brasileira de Fisiologia (Brazil)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/01/26 - 2023/01/28 Metamersion: Latent Spaces (2023)
Exhibition
 Fundação Champalimaud, Portugal
2022/10/19 - 2022/10/21 8th European Synapse Meeting (2022) MIA-Portugal, Portugal

Center of neuroscience and cell biology, Portugal
2022/10 - 2022/10 FIC.A - Festival Internacional de Ciência 2022 (2022/10 - 2022/10) MIA-Portugal, Portugal
2022/09/30 - 2022/09/30 2022 European Researchers' Night (2022) MIA-Portugal, Portugal
2022/04/04 - 2022/04/08 Ageing Spring School 2022 (2022/04/04 - 2022/04/08) MIA- Portugal , Portugal
2021/10/07 - 2021/10/15 Champalimaud Research Symposium (2021/10/13 - 2021/10/15)
Symposium (Other)
 Fundação Champalimaud, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/07 - 2022/07 EIT Health Ageing PhD School
Meeting
 Ageing - from fundamental biology to social impact
Universidade de Coimbra, Portugal
2020/02/04 - 2020/02/17 Laboratory Animal Science course (Function A & D)
Workshop
 7th Laboratory Animal Science course (Function A & D)
Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2018 - 2018 Essential Molecular Biology - 'Hands on' Laboratory Course 13th edition
Workshop
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2018 Science communication - Life and health sciences
Workshop
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - 2021 Theorical- pratical teacher Bioquímica (Licenciatura) Faculdade de Ciências da Universidade de Lisboa, Portugal
2018 - 2019 Practical course monitor Bioquímica (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Mentoring / Tutoring

Topic Student name
2020 - 2021 Synaptic proteins, synaptic plasticity and monoaminergic inputs to the hippocampus: influence of mismatch novelty training Carolina Duque-Queiroz
Distinctions

Award

2023 SPN Travel Award to participate in FRM2023
Sociedade Portuguesa de Neurociências, Portugal
2023 BEB PhD fellowship 2023

Other distinction

2021 Selected for Oral Presentation
Sociedade Brasileira de Fisiologia, Brazil
2013 Scholarship