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Pedro Henrique Gomes Soares.
Identification

Personal identification

Full name
Pedro Henrique Gomes Soares

Citation names

  • Soares, Pedro

Author identifiers

Ciência ID
101E-8BE3-B8B1
ORCID iD
0000-0002-5755-1757

Email addresses

  • pedro_hgsoares@hotmail.com (Professional)

Addresses

  • Faculty of Sciences University of Porto. Rua do Campo Alegre 1021/1055, 4169-007, Porto, Porto, Portugal (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2014/04/01 - 2018/10/20
Concluded
 PhD in Life Sciences (Doutoramento)
Major in Medicinal Chemistry and Chemical Biology
University of Dundee School of Life Sciences, United Kingdom
"Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase" (THESIS/DISSERTATION)
 Approved
2011
Concluded
 Mestrado em Química (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Síntese de Derivados de Tienopiridinas e de Tienopirimidinas como compostos Antitumorais e/ou Antiangiogénicos" (THESIS/DISSERTATION)
 16
2010
Concluded
 Licenciatura Química (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Desenvolvimento de Novos Antioxidantes Tendo Como Base Modelos Naturais" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2023/05/01 - Current Postdoc (Research) Northwestern University, United States
Northwestern University Department of Chemistry, United States
2022/06/01 - 2023/03/31 Contracted Researcher (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2020/06/01 - 2022/05/31 Contracted Researcher (Research) European Research Council, Belgium
Universidade do Porto Faculdade de Ciências, Portugal
2019/06/01 - 2020/05/31 Contracted Researcher (Research) Universidade do Porto Centro de Investigação em Química, Portugal
2014/01/01 - 2014/03/01 Contracted Researcher (Research) University of Dundee School of Life Sciences, United Kingdom

Others

Category
Host institution 		Employer
2018/09/01 - 2019/05/31 Postdoctoral Research Fellow Universidade do Porto Faculdade de Ciências, Portugal
2014/04/01 - 2018/05/01 PhD student University of Dundee School of Life Sciences, United Kingdom
2012/04/01 - 2013/11/01 Research Fellow Universidade do Porto Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2024/12/31 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2022/01/01 - 2023/06/30 Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis
EXPL/BTM-TEC/1407/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2021/06/01 - 2023/05/31 PT-OPENSCREEN - Infraestrutura Nacional para a Química Biológica e Genética
NORTE-01-0145-FEDER-085468
Researcher
Universidade do Porto Faculdade de Ciências, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2020/06/01 - 2022/05/31 MTD4ALS: Development of inovative multi-target drugs for ALS
895144
Principal investigator
Universidade do Porto Faculdade de Ciências, Portugal
 European Research Council
Ongoing
2020/03/01 - 2020/07/10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
722619
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Union
Concluded
2019/06/01 - 2020/05/31 Mito4ALS - Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype
POCI-01-0145-FEDER-029391
Researcher
Universidade do Porto Faculdade de Ciências, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/01 - 2019/05/31 Sustained Advanced Materials.
Norte-01-0145-FEDER-000028
Post-doc Fellow
Universidade do Porto Centro de Investigação em Química, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2018/09 - 2019/05/31 SkinSHIELD: Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients.
POCI-01-0145-FEDER-028607
Researcher
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2019/01 MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria.
PTDC/DTP-FTO/2433/2014
Post-doc Fellow
Universidade do Porto Faculdade de Ciências, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2018/03/31 DrugE3CRLs – Probing druggability of multisubunit complexes: E3 Cullin RING ligases.
311460
PhD Student Fellow
University of Dundee School of Life Sciences, United Kingdom
 European Research Council
Concluded
2012/04 - 2013/11 Benzopyrane a privileged structure for the rational design of multi-target compounds with potential application in neurodegenerative diseases.
PTDC/QUI-QUI/113687/2009
Master Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/10 - 2011/06 New antitumoral and antiangiogenic heterocyclic compounds: synthesis, molecular modelling, enzymatic inhibition screening and studies on tumoral and endothelial cell lines with membranar tyrosine kinase receptors as targets.
PTDC/QUI-QUI/111060/2009
Other
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Teixeira, J.; Soares, P.; Benfeito, S.; Murphy, M.P.; Oliveira, P.J.; Borges, F.. Bridging the gap between nature and antioxidant setbacks: Delivering caffeic acid to mitochondria. 2015.
Book chapter
  1. Teixeira, José; Soares, Pedro; Benfeito, Sofia; Murphy, Michael P.; Oliveira, Paulo J.; Borges, Fernanda. "Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria". In Methods in Molecular Biology, 73-83. Nova York, United States: Springer New York, 2015.
    10.1007/978-1-4939-2288-8_6
Conference poster
  1. Soares, Pedro. "THE MITOCHONDRIA-TARGETED ANTIOXIDANT ANTIOXCIN4 IS BENEFICIAL AGAINST OXIDATIVE/NITROSATIVE STRESS IN THE AMYOTROPHIC LATERAL SCLEROSIS SOD1G93A MOUSE". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  2. Soares, Pedro. "Mitochondriotropic antioxidant AntiOxCIN4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in western diet (WD)-fed mice". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  3. Soares, Pedro. "The Mitochondria-targeted antioxidant AntiOxCIN4 protects against oxidative/nitrosative stress in the Amyotrophic Lateral Sclerosis SOD1G93A mouse". 2021.
  4. Soares, Pedro. "Mitochondria-targeted antioxidant based on caffeic acid AntiOxCIN4 prevented hepatic lipid accumulation by avoided Western Diet-induced autophagic blockage". Paper presented in Digital NAFLD Summit 2021, 2021.
  5. Soares, Pedro. "DEVELOPMENT OF INNOVATIVE MULTITARGET DRUGS FOR AMYOTROPHIC LATERAL SCLEROSIS BY TARGETING NEUROINFLAMMATION AND MODULATING IRON DYSREGULATION". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  6. "Improving Nature: targeting hydroxybenzoic acids to mitochondria for neuroprotection". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, 2021.
  7. Soares, Pedro. "Mitochondriotropic antioxidants as novel therapeutics for ALS: development of multitarget agents to prevent stress induced MN death.". Paper presented in - MuTaLig COST ACTION CA15135, 4th WG meeting, 2020.
  8. Soares, Pedro. "An atypical catechol O-methyltransferase inhibitor is a remarkable modulator of hypoxia in HeLa cells". Paper presented in MuTaLig COST ACTION 4th WG meeting 2020, 2020.
  9. "Toxicological profile of phenethylamine-based psychoactive drugs". Paper presented in IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, 2019.
  10. Howard, D.M.. "From nature inspiration to multitarget small molecules: upgrading the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders.". Paper presented in MuTaLig COST ACTION CA15135, 3rd WG meeting, 2019.
    10.1049/cp:20060406
  11. Soares, Pedro. "Structure-based optimization of potent and cell active inhibitors of the pVHL-HIF-1a protein-protein interaction.". Paper presented in 19th RSC/SCI Medicinal Chemistry Symposium, 2017.
  12. Soares, Pedro. "In vitro characterization of potential biological applications of MitoK3, a novel mitochondriotropic menadione derivative.". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, 2017.
  13. Soares, Pedro. "Improvement of menadione cytotoxic potential by a mitochondria.targeted strategy.". Paper presented in MitoPorto: Advances in Mitochondrial Research International Symposium, 2017.
  14. Soares, Pedro. "VHL inhibitors as chemical probes of the hypoxia signalling pathway.". Paper presented in BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2016.
  15. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pVHL:HIF-1a protein-protein interaction.". Paper presented in SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2016.
  16. Soares, Pedro. "Development of new neurotrophic agents based on cinnamic acid.". Paper presented in I Encontro Científico do Núcleo de Estudantes de Química/Associação Académica de Coimbra (NEQ/AAC), 2015.
  17. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pVHL:HIF-1a protein-protein interaction.". Paper presented in BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2015.
  18. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pvhl:hif-1a protein-protein interaction.". Paper presented in 35th Edition of the European School of Medicinal Chemistry (ESMEC), 2015.
  19. Soares, Pedro. "Validation of pVHL as drug target using chemical probes that disrupt pVHL:HIF-1a interaction.". Paper presented in SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2015.
  20. Soares, Pedro. "Development of the next generation of small molecules targeting the pVHL:HIF-1a protein-protein interaction.". Paper presented in SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2015.
  21. Soares, Pedro. "Fine-tuning of the antimicrobial activity of caffeic acid.". Paper presented in SCT XXII Young Research Fellow Meeting, 2015.
  22. Soares, Pedro. "Development of the next generation of small molecules targeting pVHL/HIF-1a Protein-Protein Interaction.". Paper presented in BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2014.
  23. Soares, Pedro. "Validation of pVHL as drug target using chemical probes that disrupt pVHL:HIF-1a interaction.". Paper presented in BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2014.
  24. Soares, Pedro. "Drug discovery in the ubiquitin-proteasome system: targeting the von Hippel-Lindau E3 ubiquitin ligase.". Paper presented in EFMC - 23rd International Symposium on Medicinal Chemistry, 2014.
  25. Soares, Pedro. "Validating with small-molecules the VHL:HIF-1a protein:protein interaction as a new target in the hypoxia pathway.". Paper presented in III Spanish-Italian Medicinal Chemistry Congress, 2014.
  26. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". 2014.
  27. "Targeted Delivery of MitoCIN’S: a New Therapeutic Approach for Oxidative Stress Related Diseases". 2013.
  28. Soares, Pedro. "Nature-Inspired Artwork: Development of 6-(Heteroaryl/Aryl) Chromones as Novel Adenosine Receptor Ligands.". Paper presented in SEQT Summer School “Medicinal Chemistry in Drug Discovery: The Pharma Perspective”, 2013.
  29. Soares, Pedro. "Development of Smart Carriers For Delivering Menadione to Mitochondria.". Paper presented in 6th Meeting of Young Researchers of U.Porto (IJUP 2013), 2013.
  30. Soares, Pedro. "Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series.". Paper presented in 3rd Portuguese Meeting on Medicinal Chemistry/ 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  31. Soares, Pedro. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxi)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays.". Paper presented in 3rd Portuguese Meeting on Medicinal Chemistry/ 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  32. Soares, Pedro. "Bridging the gap between Nature and antioxidant setbacks: delivering hydroxybenzoic acids to mitochondria.". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  33. Soares, Pedro. "Opening a New Avenue in Neurodegenerative Therapy: Lead Optimization of a Mitochondria-Targeted Cinnamic Antioxidant.". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  34. Soares, Pedro. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects.". Paper presented in 22nd International Symposium on Medicinal Chemistry, 2012.
  35. Soares, Pedro. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenil]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays.". Paper presented in 22nd International Symposium on Medicinal Chemistry, 2012.
  36. Soares, Pedro. "Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines.". Paper presented in 22nd International Symposium on Medicinal Chemistry, 2012.
  37. Soares, Pedro. "Synthesis of di(hetero)arylamines and ethers in the thieno[3,2-b]pyridine series by metal-catalyzed couplings.". Paper presented in 6th Spanish Portuguese Japanese Organic Chemistry Symposium, 2012.
  38. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant.". Paper presented in 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  39. Soares, Pedro. "Desirability-based Multi-criteria Quantitative Structure-Selectivity Relationships of Antimicrobial Peptidomimetics.". Paper presented in 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  40. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold.". Paper presented in 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  41. Soares, Pedro. "Mitochondria-Targeted Cinnamic Antioxidants: Novel Promising Drugs for Treatment of Alzheimer disease.". Paper presented in 6th Drug Discovery for Neurodegeneration: An Intensive Course on Translating Research into Drugs, 2012.
  42. Soares, Pedro. "Synthesis of heteroarylether 1,3-diarylureas in the thieno[3,2-d]pirimidine series as VEGFR2 tyrosine kinase inhibitors: docking studies, enzymatic and cellular assays.". Paper presented in 48th Internacional Conference on Medicinal Chemistry, 2012.
  43. Dotsenko, Victor; Krivokolysko, Sergey. "Diversity-oriented Cascade Synthesis of Pyrido[2\',3\':4,5]thieno[2,3-b]pyridine Derivatives". Paper presented in 17th European Meeting of Organic Chemistry, 2011.
    10.3390/ecsoc-15-00727
  44. Soares, Pedro. "Targeting phenolic antioxidants to mitochondria: Synthesis and Characterization of novel triphenylphosphonium-conjugated lipophiliccinnamic derivatives.". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  45. Soares, Pedro. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies.". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  46. Soares, Pedro. "1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2.". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  47. Soares, Pedro. "Lipophilic Cinnamic Cations: New mitochondria-targeted antioxidants for neurodegenerative disease therapy.". Paper presented in 4th Meeting of young researchers of U.Porto (IJUP 2011), 2011.
  48. Soares, Pedro. "Synthesis of di(hetero)arylethers in the thieno[3,2-b]pyridine series by Cu-catalysed C-O coupling.". Paper presented in 4th Meeting of young researchers of U.Porto (IJUP 2011), 2011.
  49. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: mitochondria-targeted antioxidants based on cinnamic scaffold.". Paper presented in XVII National Congress of Biochemistry, 2010.
Journal article
  1. Pathum Weerawarna; Dr. Isaac Schiefer; Pedro Soares; Susan Fox; Richard I. Morimoto; Rafael D. Melani; Neil Kelleher; Chi-Hao Luan; Richard Silverman. "Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis". ACS Central Science (2023): http://dx.doi.org/10.1021/acscentsci.3c00213.
    10.1021/acscentsci.3c00213
  2. Pedro Soares; Catia Silva; Daniel Chavarria; Filomena S.G. Silva; Paulo J. Oliveira; Borges Fernanda. "Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities". Ageing Research Reviews (2023): http://dx.doi.org/10.1016/j.arr.2022.101790.
    10.1016/j.arr.2022.101790
  3. Amorim, Ricardo; Simões, Inês C.M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al. "Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology 55 (2022): 102400. http://dx.doi.org/10.1016/j.redox.2022.102400.
    10.1016/j.redox.2022.102400
  4. Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simões, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Inês; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine 179 (2022): 119-132. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304.
    10.1016/j.freeradbiomed.2021.12.304
  5. Fernandes, Carlos; Videira, Afonso J. C.; Veloso, Caroline D.; Benfeito, Sofia; Soares, Pedro; Martins, João D.; Gonçalves, Beatriz; et al. "Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis". Biomolecules 11 11 (2021): 1605. http://dx.doi.org/10.3390/biom11111605.
    10.3390/biom11111605
  6. Chavarria, Daniel; Da Silva, Ophelie Da; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329.
    10.3390/antiox10020329
  7. Silva, Vânia; Silva, Cátia; Soares, Pedro; Garrido, E. Manuela; Borges, Fernanda; Garrido, Jorge. "Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles". Molecules 25 4 (2020): 991. http://dx.doi.org/10.3390/molecules25040991.
    10.3390/molecules25040991
  8. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Silva, Catia; Gil-Martins, Eva; Soares, Pedro; Silva, Tiago; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry 185 (2020): 111770. http://dx.doi.org/10.1016/j.ejmech.2019.111770.
    10.1016/j.ejmech.2019.111770
  9. Soares, P.; Lucas, X.; Ciulli, A.. Corresponding author: Ciulli, A.. "Thioamide substitution to probe the hydroxyproline recognition of VHL ligands". Bioorganic and Medicinal Chemistry 26 11 (2018): 2992-2995. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045042834&partnerID=MN8TOARS.
    10.1016/j.bmc.2018.03.034
  10. Teixeira, J.; Amorim, R.; Santos, K.; Soares, P.; Datta, S.; Cortopassi, G.A.; Serafim, T.L.; et al. "Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative". Toxicology 393 (2018): 123-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034013034&partnerID=MN8TOARS.
    10.1016/j.tox.2017.11.014
  11. Soares, P.; Gadd, M.S.; Frost, J.; Galdeano, C.; Ellis, L.; Epemolu, O.; Rocha, S.; Read, K.D.; Ciulli, A.. Corresponding author: Ciulli, A.. "Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)". Journal of Medicinal Chemistry 61 2 (2018): 599-618. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041130365&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00675
  12. Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al. "Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models". Journal of Medicinal Chemistry 60 16 (2017): 7084-7098. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00741
  13. Hosseini, R.; Moosavi, F.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Soares, P.; Saso, L.; et al. "Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold". Chemical Biology and Drug Design 88 6 (2016): 926-937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987597648&partnerID=MN8TOARS.
    10.1111/cbdd.12829
  14. Frost, J.; Galdeano, C.; Soares, P.; Gadd, M.S.; Grzes, K.M.; Ellis, L.; Epemolu, O.; et al. Corresponding author: Ciulli, A.. "Potent and selective chemical probe of hypoxic signalling downstream of HIF-a hydroxylation via VHL inhibition". Nature Communications 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84994592337&partnerID=MN8TOARS.
    10.1038/ncomms13312
  15. Fernandes, C.; Soares, P.; Gaspar, A.; Martins, D.; Gomes, L.R.; Low, J.N.; Borges, F.. Corresponding author: Borges, F.. "Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives". Tetrahedron Letters 57 27-28 (2016): 3006-3010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973109330&partnerID=MN8TOARS.
    10.1016/j.tetlet.2016.05.096
  16. Soares, P.; Fernandes, C.; Chavarria, D.; Borges, F.. "Microwave-assisted synthesis of 5-phenyl-2-hydroxyacetophenone derivatives by a green Suzuki coupling reaction". Journal of Chemical Education 92 3 (2015): 575-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924412072&partnerID=MN8TOARS.
    10.1021/ed400498w
  17. Andrade, M.; Benfeito, S.; Soares, P.; Magalhães e Silva, D.; Loureiro, J.; Borges, A.; Borges, F.; Simões, M.. "Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli". RSC Advances 5 66 (2015): 53915-53925. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934935449&partnerID=MN8TOARS.
    10.1039/c5ra05840f
  18. Fernandes, C.; Oliveira, C.; Benfeito, S.; Soares, P.; Garrido, J.; Borges, F.. "Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases". Current Medicinal Chemistry 21 38 (2014): 4311-4327. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929085543&partnerID=MN8TOARS.
    10.2174/0929867321666140915141836
  19. Galdeano, C.; Gadd, M.S.; Soares, P.; Scaffidi, S.; Van Molle, I.; Birced, I.; Hewitt, S.; Dias, D.M.; Ciulli, A.. "Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities". Journal of Medicinal Chemistry 57 20 (2014): 8657-8663. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908373179&partnerID=MN8TOARS.
    10.1021/jm5011258
  20. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Lima, R.T.; Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.023
  21. Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F.. "Antioxidant therapy: Still in search of the 'magic bullet'". Mitochondrion 13 5 (2013): 427-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS.
    10.1016/j.mito.2012.12.002
  22. Soares, P.; Costa, R.; Froufe, H.J.C.; Calhelha, R.C.; Peixoto, D.; Ferreira, I.C.F.R.; Abreu, R.M.V.; Soares, R.; Queiroz, M.-J.R.P.. Corresponding author: Queiroz, M.-J.R.P.. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880883258&partnerID=MN8TOARS.
    10.1155/2013/154856
  23. Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS.
    10.3109/10715762.2012.662593
Journal issue
  1. Soares, Pedro. "Recent Advances in CNS Drug Discovery". Molecules (2021):
    Invited editor
Thesis / Dissertation
  1. Soares, Pedro. "Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase". PhD, University of Dundee School of Life Sciences, 2018.
  2. Soares, Pedro. "Synthesis of thienopyridine and thienopyrimidine derivatives as antitumoral and/or antiangiogenic compounds". Master, Universidade do Porto Faculdade de Ciências, 2011.
  3. Soares, Pedro. "Development of new antioxidants based on natural models". Degree, Universidade do Porto Faculdade de Ciências, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/06/10 Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for Amyotrophic Lateral Sclerosis 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
University of Bari (Bari, Italy)
2022/06/10 Mitochondriotropic antioxidants based on hydroxycinnamic acids activates Nrf2-mediated cell signalling responses to oxidative stress: Implications in Non-Alcoholic Fatty Liver Disease (NAFLD) 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
University of Bari (Bari, Italy)
2021/12/09 Protective effects of the mitochondria-targeted antioxidant antioxcin4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse 2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity
2021/12/03 Decrypting the Nfr2-dependent antioxidant protects against oxidative/nitrosative stress in the amyotrophic lateral sclerosis sod1g93a mouse
Portuguese Society for Neuroscience (Coimbra, Portugal)
2021/12 The novel mitochondria-targeted antioxidant antioxcin4 protects against oxidative stress/nitrosive stress in the amyotrophic lateral sclerosis sod1g93a mouse
2021/07 Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders
Paul Ehrlich MedChem Euro-PhD Network
2021/06 Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts
European Society for Clinical Investigation (ESCI)
2021/03/22 Development of novel therapeutic alternatives for Amyotrophic Lateral Sclerosis VII Jornadas da Química NEQUP
NEQUP (Porto, Portugal)
2021/03/19 Development of novel therapeutic alternatives for Amyotrophic Lateral Sclerosis VI Encontro Científico do NEQ/AAC
NEQ/AAC (Coimbra, Portugal)
2019/02/21 Improving the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders SCT 26th Young Research Fellows Meeting
Faculty of Pharmacy, University of Paris-Decartes (Paris, France)
2017/09/19 Structure-based optimization of potent and cell active inhibitors of the pVHL-HIF-1a protein-protein interaction 4th Young Researchers Symposium on PPIs (Protein-Portein Interactions)
School of Chemistry, University of Leeds (Leeds, United Kingdom)
2017 MitoK3, a novel mitochondriotropic menadione derivative with cytotoxic effects on cancer cells 51th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Genova, Italy)
2017 Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative VII Meeting of the Paul Ehrlich Euro-PhD Network
(Viena, Austria)
2016/04/27 Looking for new answers based on natural products for solving bacterial resistance problems 5° Encontro Português de Jovens Químicos (PYCheM)/1° Encontro Europeu de Jovens Químicos (EYCHeM)
(Guimarães, Portugal)
2016/03 Synthesis and characterization of neurotrophic factors based on phenolic compounds 4º Encontro Nacional de Estudantes de Química (ENEQUI)
(Porto, Portugal)
2015/12 Development of neurotrophic agents based on hydroxycinnamic acid scaffold 11º Encontro Nacional de Química Orgânica / 4º Encontro de Química Terapêutica
(Porto, Portugal)
2015/05/08 Caffeic acid: a natural scaffold for the development of new antimicrobial agents 2nd Symposium on Medicinal Chemistry of University of Minho
University of Minho (Porto, Portugal)
2015/05 Design and synthesis of novel antimicrobial agents inspired on phytochemicals IJUP'15 - VIII Encontro de Jovens Investigadores da Universidade do Porto
Universidade do Porto (Porto)
2014/06/05 MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria
ISANH (Lisboa, Portugal)
2013/09/27 Makeup of natural antioxidants: Design and development of smart carriers to deliver dietary phenolic acids to mitochondria
Paul Ehrlich MedChem Euro-PhD Network (Cagliari, Italy)
2013/04/17 Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study
European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/02 Mitocondriotropics derivatives based on the natural polyphenol caffeic acid as a way out for oxidative stress-related diseases 6th Meeting of Young Researchers of U.Porto (IJUP 2013),
University of Porto (Porto, Portugal)
2013/02 Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold 6th Meeting of Young Researchers of U.Porto (IJUP 2013)
University of Porto (Porto, Portugal)
2013/01/09 Development of Smart Carriers for delivering natural antioxidants to Mitochondria
Faculty of Sciences University of Porto (Porto, Portugal)
2012/02 Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage 5th Meeting of Young Researchers of U.Porto (IJUP 2012)
University of Porto (Porto, Portugal)
2011/11 Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/03/01 - 2021/06/29 Synthesis of novel multitarget molecules for the development of innovative therapies for Amyotrophic lateral sclerosis (ALS)
Supervisor
 Química (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020/03/01 - 2020/07/10 Mitochondrial oxidative Stress and remodelling Non-alcoolic fat liver disease (under MSCA ITN 722619)
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07 Avaliacao das propriedadades fisico-quimicas de fragmentos de novas entidades quimicas para o desenvolvimento de novas terapeias para doencas neurodegenerativas
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07 DESIGN OF SMART CARRIERS TO TARGET OXIDATIVE STRESS FOR ALZHEIMER DISEASE
Supervisor
 Química
Universidade do Porto Faculdade de Ciências, Portugal
2013/01 - 2013/07 Searching of a therapeutic solution for Parkinson disease
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/07 Searching of a therapeutic solution for Parkinson disease
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/07 Development of mitochondriotropic agents: An innovative therapeutic strategy for neurodegenerative diseases
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/06 Searching of a therapeutic solution for Parkinson disease
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2012/02 - 2012/06 Searching of a therapeutic solution for Parkinson disease
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2012/02 - 2012/06 Searching of a therapeutic solution for Parkinson disease
Co-supervisor
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/05/07 - 2021/05/21 First webinar on Medicinal Chemistry (2021/05/07 - 2021/05/21)
Seminar (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2018/06 - 2018/06 VII meeting of the Paul Eldrich Euro-PhD Network (2018/06 - 2018/06)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - 2011/06/15 Second Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12 - 2011/06/15)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/04/08 MITOBULLET: ANTIOXIDANT TARGETING OF MITOCHONDRIA TO PREVENT NONALCOHOLIC FATTY LIVER DISEASE-INDUCED OXIDATIVE STRESS
(Thesis) Arguer
 Ricardo Fernando Santos Amorim (PhD)
Universidade de Coimbra, Portugal
2020/09/28 A importância das fluoroquinolonas como agentes antibacterianos
(Thesis) Arguer
 Carla Lima (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2016/01 - Current Society of Chemical Industry Membro
2010/01 - Current Chemistry Research Centre of University of Porto Membro
2013/04 - 2015/03 Spanish Society of Therapeutical Chemistry Membro

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03/04 - 2022/07/20 Medicinal Chemistry Química (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2022/03/04 - 2022/07/20 Medicinal Chemistry Bioquímica (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/02/22 - 2021/06/30 Medicinal Chemistry Química (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/02/22 - 2021/06/30 Medicinal Chemistry Bioquímica (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2020/03 - 2020/06 Medicinal Chemistry Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2019/10 - 2019/11 Bioorganic Química (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
2016/03 - 2016/03 Advanced Organic Chemistry module (BS42011) Biological Chemistry and Drug Discovery (Bachelor) University of Dundee School of Life Sciences, United Kingdom
2015/03 - 2015/03 Peptide chemistry classes from the Advanced Organic Chemistry module (BS42011) Biological Chemistry and Drug Discovery (Bachelor) University of Dundee School of Life Sciences, United Kingdom
2012/11 - 2012/12 Applied Organic Chemistry Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/03 Personalidade da Universidade do Porto Newsletter ALUMNI da Universidade do Porto

Journal scientific committee

Journal title (ISSN) Publisher
2021/01 - Current Antioxidants (2076-3921) MDPI
2021/01 - Current International Journal of Environmental Research and Public Health (1660-4601) MDPI
2020/01/10 - Current Molecules (1420-3049) MDPI
Distinctions

Award

2020 best poster prize in the MuTaLig COST ACTION CA15135, 4th WG meeting,
European Cooperation in Science and Technology, Belgium
2019 best poster prize in the MuTaLig COST ACTION CA15135, 3rd WG meeting
European Cooperation in Science and Technology, Belgium
2015 Best poster prize at the BCDD department retreat, 13th November 2015, Dundee, Scotland, UK.
University of Dundee Division of Biological Chemistry and Drug Discovery, United Kingdom
2014 Co-author of one of the best poster prizes from the 23rd International Symposium on Medicinal Chemistry

Other distinction

2020 MSCA - Individual Fellowship
European Research Council, Belgium
2017 Bursary to participate in the 19th RSC/SCI Medicinal Chemistry Symposium
Society of Chemical Industry, United Kingdom
2015 PhD studentship (April 2015 - May 2018) - Studentship reference: SFRH/BD/101598/2014 – Basic Medicine and Biomedicine Panel – Specific Subject Medicinal Chemistry – Project title: “Novel Approaches to Interrogate the Druggability of E3 Cullin RING Ubi
Fundação para a Ciência e a Tecnologia, Portugal
2015 Highly read article of 2014 in the Journal of Medicinal Chemistry (article J. Med. Chem. 2014, 57(20), 8657-8663, DOI: 10.1021/jm5011258)
American Chemical Society, United States
2014 BBSRC/ERC PhD studentship (April 2014 - March 2015) – Studentship reference: 355.050502.D45 – Project title: “Small-molecule Approaches to Interrogate the Druggability of the VHL E3 Cullin RING Ubiquitin Ligase”
Biotechnology and Biological Sciences Research Council, United Kingdom

European Research Council, Belgium
2013 Master graduate fellowship from the FCT project (April 2012- November 2013) - PTDC/QUI-QUI/113687/2009 – “BP4Brain – Benzopyrane a privileged structure for the rational design of multi-target compounds with potential application in neurodegenerative...
Fundação para a Ciência e a Tecnologia, Portugal