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Pedro Henrique Gomes Soares.
Identificação

Identificação pessoal

Nome completo
Pedro Henrique Gomes Soares

Nomes de citação

  • Soares, Pedro

Identificadores de autor

Ciência ID
101E-8BE3-B8B1
ORCID iD
0000-0002-5755-1757

Endereços de correio eletrónico

  • pedro_hgsoares@hotmail.com (Profissional)

Moradas

  • Faculty of Sciences University of Porto. Rua do Campo Alegre 1021/1055, 4169-007, Porto, Porto, Portugal (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Formação
Grau Classificação
2014/04/01 - 2018/10/20
Concluído
 PhD in Life Sciences (Doutoramento)
Especialização em Medicinal Chemistry and Chemical Biology
University of Dundee School of Life Sciences, Reino Unido
"Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase" (TESE/DISSERTAÇÃO)
 Approved
2011
Concluído
 Mestrado em Química (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Síntese de Derivados de Tienopiridinas e de Tienopirimidinas como compostos Antitumorais e/ou Antiangiogénicos" (TESE/DISSERTAÇÃO)
 16
2010
Concluído
 Licenciatura Química (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Desenvolvimento de Novos Antioxidantes Tendo Como Base Modelos Naturais" (TESE/DISSERTAÇÃO)
 13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/05/01 - Atual Pós-doutorado (Investigação) Northwestern University, Estados Unidos
Northwestern University Department of Chemistry, Estados Unidos
2022/06/01 - 2023/03/31 Investigador Contratado (Investigação) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2020/06/01 - 2022/05/31 Investigador Contratado (Investigação) European Research Council, Bélgica
Universidade do Porto Faculdade de Ciências, Portugal
2019/06/01 - 2020/05/31 Investigador Contratado (Investigação) Universidade do Porto Centro de Investigação em Química, Portugal
2014/01/01 - 2014/03/01 Investigador Contratado (Investigação) University of Dundee School of Life Sciences, Reino Unido

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/09/01 - 2019/05/31 Postdoctoral Research Fellow Universidade do Porto Faculdade de Ciências, Portugal
2014/04/01 - 2018/05/01 PhD student University of Dundee School of Life Sciences, Reino Unido
2012/04/01 - 2013/11/01 Research Fellow Universidade do Porto Faculdade de Ciências, Portugal
Projetos

Projeto

Designação Financiadores
2022/01/01 - 2024/12/31 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2022/01/01 - 2023/06/30 Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis
EXPL/BTM-TEC/1407/2021
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2021/06/01 - 2023/05/31 PT-OPENSCREEN - Infraestrutura Nacional para a Química Biológica e Genética
NORTE-01-0145-FEDER-085468
Investigador
Universidade do Porto Faculdade de Ciências, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Em curso
2020/06/01 - 2022/05/31 MTD4ALS: Development of inovative multi-target drugs for ALS
895144
Investigador responsável
Universidade do Porto Faculdade de Ciências, Portugal
 European Research Council
Em curso
2020/03/01 - 2020/07/10 Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
722619
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Union
Concluído
2019/06/01 - 2020/05/31 Mito4ALS - Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype
POCI-01-0145-FEDER-029391
Investigador
Universidade do Porto Faculdade de Ciências, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/02/01 - 2019/05/31 Sustained Advanced Materials.
Norte-01-0145-FEDER-000028
Bolseiro de Pós-Doutoramento
Universidade do Porto Centro de Investigação em Química, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2018/09 - 2019/05/31 SkinSHIELD: Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients.
POCI-01-0145-FEDER-028607
Investigador
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10 - 2019/01 MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria.
PTDC/DTP-FTO/2433/2014
Bolseiro de Pós-Doutoramento
Universidade do Porto Faculdade de Ciências, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/04/01 - 2018/03/31 DrugE3CRLs – Probing druggability of multisubunit complexes: E3 Cullin RING ligases.
311460
Bolseiro de Doutoramento
University of Dundee School of Life Sciences, Reino Unido
 European Research Council
Concluído
2012/04 - 2013/11 Benzopyrane a privileged structure for the rational design of multi-target compounds with potential application in neurodegenerative diseases.
PTDC/QUI-QUI/113687/2009
Bolseiro de Mestrado
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/10 - 2011/06 New antitumoral and antiangiogenic heterocyclic compounds: synthesis, molecular modelling, enzymatic inhibition screening and studies on tumoral and endothelial cell lines with membranar tyrosine kinase receptors as targets.
PTDC/QUI-QUI/111060/2009
Outra
Universidade do Minho Centro de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Pathum Weerawarna; Dr. Isaac Schiefer; Pedro Soares; Susan Fox; Richard I. Morimoto; Rafael D. Melani; Neil Kelleher; Chi-Hao Luan; Richard Silverman. "Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis". ACS Central Science (2023): http://dx.doi.org/10.1021/acscentsci.3c00213.
    10.1021/acscentsci.3c00213
  2. Pedro Soares; Catia Silva; Daniel Chavarria; Filomena S.G. Silva; Paulo J. Oliveira; Borges Fernanda. "Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities". Ageing Research Reviews (2023): http://dx.doi.org/10.1016/j.arr.2022.101790.
    10.1016/j.arr.2022.101790
  3. Amorim, Ricardo; Simões, Inês C.M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al. "Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology 55 (2022): 102400. http://dx.doi.org/10.1016/j.redox.2022.102400.
    10.1016/j.redox.2022.102400
  4. Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simões, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Inês; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine 179 (2022): 119-132. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304.
    10.1016/j.freeradbiomed.2021.12.304
  5. Fernandes, Carlos; Videira, Afonso J. C.; Veloso, Caroline D.; Benfeito, Sofia; Soares, Pedro; Martins, João D.; Gonçalves, Beatriz; et al. "Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis". Biomolecules 11 11 (2021): 1605. http://dx.doi.org/10.3390/biom11111605.
    10.3390/biom11111605
  6. Chavarria, Daniel; Da Silva, Ophelie Da; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329.
    10.3390/antiox10020329
  7. Silva, Vânia; Silva, Cátia; Soares, Pedro; Garrido, E. Manuela; Borges, Fernanda; Garrido, Jorge. "Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles". Molecules 25 4 (2020): 991. http://dx.doi.org/10.3390/molecules25040991.
    10.3390/molecules25040991
  8. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Silva, Catia; Gil-Martins, Eva; Soares, Pedro; Silva, Tiago; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry 185 (2020): 111770. http://dx.doi.org/10.1016/j.ejmech.2019.111770.
    10.1016/j.ejmech.2019.111770
  9. Soares, P.; Lucas, X.; Ciulli, A.. Autor correspondente: Ciulli, A.. "Thioamide substitution to probe the hydroxyproline recognition of VHL ligands". Bioorganic and Medicinal Chemistry 26 11 (2018): 2992-2995. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045042834&partnerID=MN8TOARS.
    10.1016/j.bmc.2018.03.034
  10. Teixeira, J.; Amorim, R.; Santos, K.; Soares, P.; Datta, S.; Cortopassi, G.A.; Serafim, T.L.; et al. "Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative". Toxicology 393 (2018): 123-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034013034&partnerID=MN8TOARS.
    10.1016/j.tox.2017.11.014
  11. Soares, P.; Gadd, M.S.; Frost, J.; Galdeano, C.; Ellis, L.; Epemolu, O.; Rocha, S.; Read, K.D.; Ciulli, A.. Autor correspondente: Ciulli, A.. "Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)". Journal of Medicinal Chemistry 61 2 (2018): 599-618. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041130365&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00675
  12. Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al. "Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models". Journal of Medicinal Chemistry 60 16 (2017): 7084-7098. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00741
  13. Hosseini, R.; Moosavi, F.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Soares, P.; Saso, L.; et al. "Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold". Chemical Biology and Drug Design 88 6 (2016): 926-937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987597648&partnerID=MN8TOARS.
    10.1111/cbdd.12829
  14. Frost, J.; Galdeano, C.; Soares, P.; Gadd, M.S.; Grzes, K.M.; Ellis, L.; Epemolu, O.; et al. Autor correspondente: Ciulli, A.. "Potent and selective chemical probe of hypoxic signalling downstream of HIF-a hydroxylation via VHL inhibition". Nature Communications 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84994592337&partnerID=MN8TOARS.
    10.1038/ncomms13312
  15. Fernandes, C.; Soares, P.; Gaspar, A.; Martins, D.; Gomes, L.R.; Low, J.N.; Borges, F.. Autor correspondente: Borges, F.. "Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives". Tetrahedron Letters 57 27-28 (2016): 3006-3010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973109330&partnerID=MN8TOARS.
    10.1016/j.tetlet.2016.05.096
  16. Soares, P.; Fernandes, C.; Chavarria, D.; Borges, F.. "Microwave-assisted synthesis of 5-phenyl-2-hydroxyacetophenone derivatives by a green Suzuki coupling reaction". Journal of Chemical Education 92 3 (2015): 575-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924412072&partnerID=MN8TOARS.
    10.1021/ed400498w
  17. Andrade, M.; Benfeito, S.; Soares, P.; Magalhães e Silva, D.; Loureiro, J.; Borges, A.; Borges, F.; Simões, M.. "Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli". RSC Advances 5 66 (2015): 53915-53925. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934935449&partnerID=MN8TOARS.
    10.1039/c5ra05840f
  18. Fernandes, C.; Oliveira, C.; Benfeito, S.; Soares, P.; Garrido, J.; Borges, F.. "Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases". Current Medicinal Chemistry 21 38 (2014): 4311-4327. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929085543&partnerID=MN8TOARS.
    10.2174/0929867321666140915141836
  19. Galdeano, C.; Gadd, M.S.; Soares, P.; Scaffidi, S.; Van Molle, I.; Birced, I.; Hewitt, S.; Dias, D.M.; Ciulli, A.. "Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities". Journal of Medicinal Chemistry 57 20 (2014): 8657-8663. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908373179&partnerID=MN8TOARS.
    10.1021/jm5011258
  20. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Lima, R.T.; Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.023
  21. Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F.. "Antioxidant therapy: Still in search of the 'magic bullet'". Mitochondrion 13 5 (2013): 427-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS.
    10.1016/j.mito.2012.12.002
  22. Soares, P.; Costa, R.; Froufe, H.J.C.; Calhelha, R.C.; Peixoto, D.; Ferreira, I.C.F.R.; Abreu, R.M.V.; Soares, R.; Queiroz, M.-J.R.P.. Autor correspondente: Queiroz, M.-J.R.P.. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880883258&partnerID=MN8TOARS.
    10.1155/2013/154856
  23. Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS.
    10.3109/10715762.2012.662593
Capítulo de livro
  1. Teixeira, José; Soares, Pedro; Benfeito, Sofia; Murphy, Michael P.; Oliveira, Paulo J.; Borges, Fernanda. "Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria". In Methods in Molecular Biology, 73-83. Nova York, Estados Unidos: Springer New York, 2015.
    10.1007/978-1-4939-2288-8_6
Edição de número de revista
  1. Soares, Pedro. "Recent Advances in CNS Drug Discovery". Molecules (2021):
    Editor convidado
Livro
  1. Teixeira, J.; Soares, P.; Benfeito, S.; Murphy, M.P.; Oliveira, P.J.; Borges, F.. Bridging the gap between nature and antioxidant setbacks: Delivering caffeic acid to mitochondria. 2015.
Poster em conferência
  1. Soares, Pedro. "THE MITOCHONDRIA-TARGETED ANTIOXIDANT ANTIOXCIN4 IS BENEFICIAL AGAINST OXIDATIVE/NITROSATIVE STRESS IN THE AMYOTROPHIC LATERAL SCLEROSIS SOD1G93A MOUSE". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  2. Soares, Pedro. "Mitochondriotropic antioxidant AntiOxCIN4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in western diet (WD)-fed mice". Trabalho apresentado em 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2022.
  3. Soares, Pedro. "The Mitochondria-targeted antioxidant AntiOxCIN4 protects against oxidative/nitrosative stress in the Amyotrophic Lateral Sclerosis SOD1G93A mouse". 2021.
  4. Soares, Pedro. "Mitochondria-targeted antioxidant based on caffeic acid AntiOxCIN4 prevented hepatic lipid accumulation by avoided Western Diet-induced autophagic blockage". Trabalho apresentado em Digital NAFLD Summit 2021, 2021.
  5. Soares, Pedro. "DEVELOPMENT OF INNOVATIVE MULTITARGET DRUGS FOR AMYOTROPHIC LATERAL SCLEROSIS BY TARGETING NEUROINFLAMMATION AND MODULATING IRON DYSREGULATION". Trabalho apresentado em XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021), 2021.
  6. "Improving Nature: targeting hydroxybenzoic acids to mitochondria for neuroprotection". Trabalho apresentado em 55th Annual meeting of the European Society for Clinical Investigation, 2021.
  7. Soares, Pedro. "Mitochondriotropic antioxidants as novel therapeutics for ALS: development of multitarget agents to prevent stress induced MN death.". Trabalho apresentado em - MuTaLig COST ACTION CA15135, 4th WG meeting, 2020.
  8. Soares, Pedro. "An atypical catechol O-methyltransferase inhibitor is a remarkable modulator of hypoxia in HeLa cells". Trabalho apresentado em MuTaLig COST ACTION 4th WG meeting 2020, 2020.
  9. "Toxicological profile of phenethylamine-based psychoactive drugs". Trabalho apresentado em IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, 2019.
  10. Howard, D.M.. "From nature inspiration to multitarget small molecules: upgrading the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders.". Trabalho apresentado em MuTaLig COST ACTION CA15135, 3rd WG meeting, 2019.
    10.1049/cp:20060406
  11. Soares, Pedro. "Structure-based optimization of potent and cell active inhibitors of the pVHL-HIF-1a protein-protein interaction.". Trabalho apresentado em 19th RSC/SCI Medicinal Chemistry Symposium, 2017.
  12. Soares, Pedro. "In vitro characterization of potential biological applications of MitoK3, a novel mitochondriotropic menadione derivative.". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, 2017.
  13. Soares, Pedro. "Improvement of menadione cytotoxic potential by a mitochondria.targeted strategy.". Trabalho apresentado em MitoPorto: Advances in Mitochondrial Research International Symposium, 2017.
  14. Soares, Pedro. "VHL inhibitors as chemical probes of the hypoxia signalling pathway.". Trabalho apresentado em BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2016.
  15. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pVHL:HIF-1a protein-protein interaction.". Trabalho apresentado em SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2016.
  16. Soares, Pedro. "Development of new neurotrophic agents based on cinnamic acid.". Trabalho apresentado em I Encontro Científico do Núcleo de Estudantes de Química/Associação Académica de Coimbra (NEQ/AAC), 2015.
  17. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pVHL:HIF-1a protein-protein interaction.". Trabalho apresentado em BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2015.
  18. Soares, Pedro. "Structure-based optimization and biophysical characterization of small molecule inhibitors of the pvhl:hif-1a protein-protein interaction.". Trabalho apresentado em 35th Edition of the European School of Medicinal Chemistry (ESMEC), 2015.
  19. Soares, Pedro. "Validation of pVHL as drug target using chemical probes that disrupt pVHL:HIF-1a interaction.". Trabalho apresentado em SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2015.
  20. Soares, Pedro. "Development of the next generation of small molecules targeting the pVHL:HIF-1a protein-protein interaction.". Trabalho apresentado em SLS (School of Life Sciences of University of Dundee) Annual Symposium, 2015.
  21. Soares, Pedro. "Fine-tuning of the antimicrobial activity of caffeic acid.". Trabalho apresentado em SCT XXII Young Research Fellow Meeting, 2015.
  22. Soares, Pedro. "Development of the next generation of small molecules targeting pVHL/HIF-1a Protein-Protein Interaction.". Trabalho apresentado em BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2014.
  23. Soares, Pedro. "Validation of pVHL as drug target using chemical probes that disrupt pVHL:HIF-1a interaction.". Trabalho apresentado em BCDD (Biological chemistry and drug discovery) department of the School of Life Sciences of University of Dundee annual retreat, 2014.
  24. Soares, Pedro. "Drug discovery in the ubiquitin-proteasome system: targeting the von Hippel-Lindau E3 ubiquitin ligase.". Trabalho apresentado em EFMC - 23rd International Symposium on Medicinal Chemistry, 2014.
  25. Soares, Pedro. "Validating with small-molecules the VHL:HIF-1a protein:protein interaction as a new target in the hypoxia pathway.". Trabalho apresentado em III Spanish-Italian Medicinal Chemistry Congress, 2014.
  26. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". 2014.
  27. "Targeted Delivery of MitoCIN’S: a New Therapeutic Approach for Oxidative Stress Related Diseases". 2013.
  28. Soares, Pedro. "Nature-Inspired Artwork: Development of 6-(Heteroaryl/Aryl) Chromones as Novel Adenosine Receptor Ligands.". Trabalho apresentado em SEQT Summer School “Medicinal Chemistry in Drug Discovery: The Pharma Perspective”, 2013.
  29. Soares, Pedro. "Development of Smart Carriers For Delivering Menadione to Mitochondria.". Trabalho apresentado em 6th Meeting of Young Researchers of U.Porto (IJUP 2013), 2013.
  30. Soares, Pedro. "Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series.". Trabalho apresentado em 3rd Portuguese Meeting on Medicinal Chemistry/ 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  31. Soares, Pedro. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxi)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays.". Trabalho apresentado em 3rd Portuguese Meeting on Medicinal Chemistry/ 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  32. Soares, Pedro. "Bridging the gap between Nature and antioxidant setbacks: delivering hydroxybenzoic acids to mitochondria.". Trabalho apresentado em 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  33. Soares, Pedro. "Opening a New Avenue in Neurodegenerative Therapy: Lead Optimization of a Mitochondria-Targeted Cinnamic Antioxidant.". Trabalho apresentado em 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  34. Soares, Pedro. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects.". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, 2012.
  35. Soares, Pedro. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenil]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays.". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, 2012.
  36. Soares, Pedro. "Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines.". Trabalho apresentado em 22nd International Symposium on Medicinal Chemistry, 2012.
  37. Soares, Pedro. "Synthesis of di(hetero)arylamines and ethers in the thieno[3,2-b]pyridine series by metal-catalyzed couplings.". Trabalho apresentado em 6th Spanish Portuguese Japanese Organic Chemistry Symposium, 2012.
  38. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant.". Trabalho apresentado em 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  39. Soares, Pedro. "Desirability-based Multi-criteria Quantitative Structure-Selectivity Relationships of Antimicrobial Peptidomimetics.". Trabalho apresentado em 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  40. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold.". Trabalho apresentado em 5th Meeting of Young Researchers of U.Porto (IJUP 2012), 2012.
  41. Soares, Pedro. "Mitochondria-Targeted Cinnamic Antioxidants: Novel Promising Drugs for Treatment of Alzheimer disease.". Trabalho apresentado em 6th Drug Discovery for Neurodegeneration: An Intensive Course on Translating Research into Drugs, 2012.
  42. Soares, Pedro. "Synthesis of heteroarylether 1,3-diarylureas in the thieno[3,2-d]pirimidine series as VEGFR2 tyrosine kinase inhibitors: docking studies, enzymatic and cellular assays.". Trabalho apresentado em 48th Internacional Conference on Medicinal Chemistry, 2012.
  43. Dotsenko, Victor; Krivokolysko, Sergey. "Diversity-oriented Cascade Synthesis of Pyrido[2\',3\':4,5]thieno[2,3-b]pyridine Derivatives". Trabalho apresentado em 17th European Meeting of Organic Chemistry, 2011.
    10.3390/ecsoc-15-00727
  44. Soares, Pedro. "Targeting phenolic antioxidants to mitochondria: Synthesis and Characterization of novel triphenylphosphonium-conjugated lipophiliccinnamic derivatives.". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  45. Soares, Pedro. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies.". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  46. Soares, Pedro. "1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2.". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2IMMC), 2011.
  47. Soares, Pedro. "Lipophilic Cinnamic Cations: New mitochondria-targeted antioxidants for neurodegenerative disease therapy.". Trabalho apresentado em 4th Meeting of young researchers of U.Porto (IJUP 2011), 2011.
  48. Soares, Pedro. "Synthesis of di(hetero)arylethers in the thieno[3,2-b]pyridine series by Cu-catalysed C-O coupling.". Trabalho apresentado em 4th Meeting of young researchers of U.Porto (IJUP 2011), 2011.
  49. Soares, Pedro. "Opening a new avenue in neurodegenerative therapy: mitochondria-targeted antioxidants based on cinnamic scaffold.". Trabalho apresentado em XVII National Congress of Biochemistry, 2010.
Tese / Dissertação
  1. Soares, Pedro. "Small-molecule approaches to interrogate the druggability of the VHL E3 Cullin RING Ubiquitin Ligase". Doutoramento, University of Dundee School of Life Sciences, 2018.
  2. Soares, Pedro. "Synthesis of thienopyridine and thienopyrimidine derivatives as antitumoral and/or antiangiogenic compounds". Mestrado, Universidade do Porto Faculdade de Ciências, 2011.
  3. Soares, Pedro. "Development of new antioxidants based on natural models". Licenciatura, Universidade do Porto Faculdade de Ciências, 2010.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/06/10 Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for Amyotrophic Lateral Sclerosis 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
University of Bari (Bari, Itália)
2022/06/10 Mitochondriotropic antioxidants based on hydroxycinnamic acids activates Nrf2-mediated cell signalling responses to oxidative stress: Implications in Non-Alcoholic Fatty Liver Disease (NAFLD) 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
University of Bari (Bari, Itália)
2021/12/09 Protective effects of the mitochondria-targeted antioxidant antioxcin4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse 2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity
2021/12/03 Decrypting the Nfr2-dependent antioxidant protects against oxidative/nitrosative stress in the amyotrophic lateral sclerosis sod1g93a mouse
Portuguese Society for Neuroscience (Coimbra, Portugal)
2021/12 The novel mitochondria-targeted antioxidant antioxcin4 protects against oxidative stress/nitrosive stress in the amyotrophic lateral sclerosis sod1g93a mouse
2021/07 Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders
Paul Ehrlich MedChem Euro-PhD Network
2021/06 Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts
European Society for Clinical Investigation (ESCI)
2021/03/22 Development of novel therapeutic alternatives for Amyotrophic Lateral Sclerosis VII Jornadas da Química NEQUP
NEQUP (Porto, Portugal)
2021/03/19 Development of novel therapeutic alternatives for Amyotrophic Lateral Sclerosis VI Encontro Científico do NEQ/AAC
NEQ/AAC (Coimbra, Portugal)
2019/02/21 Improving the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders SCT 26th Young Research Fellows Meeting
Faculty of Pharmacy, University of Paris-Decartes (Paris, França)
2017/09/19 Structure-based optimization of potent and cell active inhibitors of the pVHL-HIF-1a protein-protein interaction 4th Young Researchers Symposium on PPIs (Protein-Portein Interactions)
School of Chemistry, University of Leeds (Leeds, Reino Unido)
2017 MitoK3, a novel mitochondriotropic menadione derivative with cytotoxic effects on cancer cells 51th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Genova, Itália)
2017 Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative VII Meeting of the Paul Ehrlich Euro-PhD Network
(Viena, Áustria)
2016/04/27 Looking for new answers based on natural products for solving bacterial resistance problems 5° Encontro Português de Jovens Químicos (PYCheM)/1° Encontro Europeu de Jovens Químicos (EYCHeM)
(Guimarães, Portugal)
2016/03 Synthesis and characterization of neurotrophic factors based on phenolic compounds 4º Encontro Nacional de Estudantes de Química (ENEQUI)
(Porto, Portugal)
2015/12 Development of neurotrophic agents based on hydroxycinnamic acid scaffold 11º Encontro Nacional de Química Orgânica / 4º Encontro de Química Terapêutica
(Porto, Portugal)
2015/05/08 Caffeic acid: a natural scaffold for the development of new antimicrobial agents 2nd Symposium on Medicinal Chemistry of University of Minho
University of Minho (Porto, Portugal)
2015/05 Design and synthesis of novel antimicrobial agents inspired on phytochemicals IJUP'15 - VIII Encontro de Jovens Investigadores da Universidade do Porto
Universidade do Porto (Porto)
2014/06/05 MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria
ISANH (Lisboa, Portugal)
2013/09/27 Makeup of natural antioxidants: Design and development of smart carriers to deliver dietary phenolic acids to mitochondria
Paul Ehrlich MedChem Euro-PhD Network (Cagliari, Itália)
2013/04/17 Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study
European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/02 Mitocondriotropics derivatives based on the natural polyphenol caffeic acid as a way out for oxidative stress-related diseases 6th Meeting of Young Researchers of U.Porto (IJUP 2013),
University of Porto (Porto, Portugal)
2013/02 Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold 6th Meeting of Young Researchers of U.Porto (IJUP 2013)
University of Porto (Porto, Portugal)
2013/01/09 Development of Smart Carriers for delivering natural antioxidants to Mitochondria
Faculty of Sciences University of Porto (Porto, Portugal)
2012/02 Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage 5th Meeting of Young Researchers of U.Porto (IJUP 2012)
University of Porto (Porto, Portugal)
2011/11 Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Roma, Itália)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/03/01 - 2021/06/29 Synthesis of novel multitarget molecules for the development of innovative therapies for Amyotrophic lateral sclerosis (ALS)
Orientador
 Química (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2020/03/01 - 2020/07/10 Mitochondrial oxidative Stress and remodelling Non-alcoolic fat liver disease (under MSCA ITN 722619)
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07 Avaliacao das propriedadades fisico-quimicas de fragmentos de novas entidades quimicas para o desenvolvimento de novas terapeias para doencas neurodegenerativas
Orientador
Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07 DESIGN OF SMART CARRIERS TO TARGET OXIDATIVE STRESS FOR ALZHEIMER DISEASE
Orientador
 Química
Universidade do Porto Faculdade de Ciências, Portugal
2013/01 - 2013/07 Searching of a therapeutic solution for Parkinson disease
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/07 Searching of a therapeutic solution for Parkinson disease
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/07 Development of mitochondriotropic agents: An innovative therapeutic strategy for neurodegenerative diseases
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2012/09 - 2013/06 Searching of a therapeutic solution for Parkinson disease
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2012/02 - 2012/06 Searching of a therapeutic solution for Parkinson disease
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal
2012/02 - 2012/06 Searching of a therapeutic solution for Parkinson disease
Coorientador
Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/05/07 - 2021/05/21 First webinar on Medicinal Chemistry (2021/05/07 - 2021/05/21)
Seminário (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2018/06 - 2018/06 VII meeting of the Paul Eldrich Euro-PhD Network (2018/06 - 2018/06)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - 2011/06/15 Second Iberic Meeting on Medicinal Chemistry – G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12 - 2011/06/15)
Conferência (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/04/08 MITOBULLET: ANTIOXIDANT TARGETING OF MITOCHONDRIA TO PREVENT NONALCOHOLIC FATTY LIVER DISEASE-INDUCED OXIDATIVE STRESS
Arguente
 Ricardo Fernando Santos Amorim (Doutoramento)
Universidade de Coimbra, Portugal
2020/09/28 A importância das fluoroquinolonas como agentes antibacterianos
Arguente
 Carla Lima (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/01 - Atual Antioxidants (2076-3921) MDPI
2021/01 - Atual International Journal of Environmental Research and Public Health (1660-4601) MDPI
2020/01/10 - Atual Molecules (1420-3049) MDPI

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/03/04 - 2022/07/20 Medicinal Chemistry Química (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2022/03/04 - 2022/07/20 Medicinal Chemistry Bioquímica (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/02/22 - 2021/06/30 Medicinal Chemistry Química (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/02/22 - 2021/06/30 Medicinal Chemistry Bioquímica (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2020/03 - 2020/06 Medicinal Chemistry Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2019/10 - 2019/11 Bioorganic Química (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
2016/03 - 2016/03 Advanced Organic Chemistry module (BS42011) Biological Chemistry and Drug Discovery (Bachelor) University of Dundee School of Life Sciences, Reino Unido
2015/03 - 2015/03 Peptide chemistry classes from the Advanced Organic Chemistry module (BS42011) Biological Chemistry and Drug Discovery (Bachelor) University of Dundee School of Life Sciences, Reino Unido
2012/11 - 2012/12 Applied Organic Chemistry Química (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/03 Personalidade da Universidade do Porto Newsletter ALUMNI da Universidade do Porto

Membro de associação

Nome da associação Tipo de participação
2016/01 - Atual Society of Chemical Industry Membro
2010/01 - Atual Chemistry Research Centre of University of Porto Membro
2013/04 - 2015/03 Spanish Society of Therapeutical Chemistry Membro
Distinções

Prémio

2020 best poster prize in the MuTaLig COST ACTION CA15135, 4th WG meeting,
European Cooperation in Science and Technology, Bélgica
2019 best poster prize in the MuTaLig COST ACTION CA15135, 3rd WG meeting
European Cooperation in Science and Technology, Bélgica
2015 Best poster prize at the BCDD department retreat, 13th November 2015, Dundee, Scotland, UK.
University of Dundee Division of Biological Chemistry and Drug Discovery, Reino Unido
2014 Co-author of one of the best poster prizes from the 23rd International Symposium on Medicinal Chemistry

Outra distinção

2020 MSCA - Individual Fellowship
European Research Council, Bélgica
2017 Bursary to participate in the 19th RSC/SCI Medicinal Chemistry Symposium
Society of Chemical Industry, Reino Unido
2015 PhD studentship (April 2015 - May 2018) - Studentship reference: SFRH/BD/101598/2014 – Basic Medicine and Biomedicine Panel – Specific Subject Medicinal Chemistry – Project title: “Novel Approaches to Interrogate the Druggability of E3 Cullin RING Ubi
Fundação para a Ciência e a Tecnologia, Portugal
2015 Highly read article of 2014 in the Journal of Medicinal Chemistry (article J. Med. Chem. 2014, 57(20), 8657-8663, DOI: 10.1021/jm5011258)
American Chemical Society, Estados Unidos
2014 BBSRC/ERC PhD studentship (April 2014 - March 2015) – Studentship reference: 355.050502.D45 – Project title: “Small-molecule Approaches to Interrogate the Druggability of the VHL E3 Cullin RING Ubiquitin Ligase”
Biotechnology and Biological Sciences Research Council, Reino Unido

European Research Council, Bélgica
2013 Master graduate fellowship from the FCT project (April 2012- November 2013) - PTDC/QUI-QUI/113687/2009 – “BP4Brain – Benzopyrane a privileged structure for the rational design of multi-target compounds with potential application in neurodegenerative...
Fundação para a Ciência e a Tecnologia, Portugal