Marco Calvinho Cavaco (1412-63B8-7494)

Curriculum Vitae

Marco Calvinho Cavaco

Marco Cavaco (H-index 14) has a PhD in Biomedical Sciences from Lisbon School of Medicine and an MSc in Pharmaceutical Sciences from the Lisbon School of Pharmacy. His main interests have been the design and study of anticancer peptides, brain-penetrating peptides, and peptide conjugates (e.g., small molecule drugs, antibody fragments, proteins); as well as the development of more robust preclinical models (organ-on-chip, spheroids). He applies a wide range of research techniques, including chemistry (peptide synthesis, derivatization, and conjugation), biophysical techniques (spectroscopy, dynamic light scattering, microscopy, flow cytometry), molecular and cellular biochemical techniques (cell culture – spheroids, blood-brain barrier (BBB) models , co-culture, viability assays, ELISA, PCR, Western Blot, cell organelle trafficking, immunofluorescence, and chromatography (HPLC). Marco has published more than 30 papers in international peer-reviewed journals; he has 2 patents and has presented his work (poster or orally) in 20 national/international meetings. The positive results from his work were the foundations for three national and one international successful applications where he is a team member. He is a co-Pi in another national successful application. Additionally, he has mentored national and international research students (8 PhD students, 3 MSc students, 2 ERASMUS students, and 2 medical students). He is also currently supervising 1 PhD student and 1 MSc student. He has enrolled in the organization of scientific events, participated in diverse outreach activities to promote science, and took part of scientific committees for the evaluation of master thesis and peer-review of submitted research papers.

Read full resume ↓

Identification

Personal identification

Full name: Marco Calvinho Cavaco

Citation names

Cavaco, Marco
Cavaco, M

Author identifiers

Ciência ID: 1412-63B8-7494
ORCID iD: 0000-0002-0938-9038
Google Scholar ID: https://scholar.google.com/citations?user=s-9kd_cAAAAJ&hl=en

Email addresses

marco.cavaco@gimm.pt (Professional)
mcavaco@medicina.ulisboa.pt (Personal)

Telephones

Telephone

(351) 217985136 Ext.: 47256 (Professional)

Addresses

Av prof Egas Moniz , 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Natural sciences - Biological Sciences
Medical and Health Sciences - Medical Biotechnology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2022/04/01 - 2032 Ongoing	Pos-doc (Pós-doutoramento) Instituto de Medicina Molecular, Portugal
2017/01/01 - 2022/03/23 Concluded	Biomedical Sciences (Doutoramento) Instituto de Medicina Molecular, Portugal
2021 - 2021 Concluded	VIII Cell Culture and Tissue Training Course (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal
2020 - 2020 Concluded	Graphic Design by Christof De Bo (Outros) Instituto de Medicina Molecular, Portugal
2019 - 2019 Concluded	Scientific Writing Course "Preparing a hypothesis-driven research paper" by Marcia Triunfol (Outros) Instituto de Medicina Molecular, Portugal
2019 - 2019 Concluded	Workshop "Basics of Programming" by Filipe Cadete (Outros) Instituto de Medicina Molecular, Portugal
2017 - 2018 Concluded	Laboratory Animal Science (for function A, C and D of rodents and fish, according to Directive 2010/63/EU) (Outros) Instituto de Medicina Molecular, Portugal
2017 - 2017 Concluded	Workshop "Communication: Turn yourself into a successful speaker" by Malcolm Love (Outros) Instituto de Medicina Molecular, Portugal
2017 - 2017 Concluded	1st FLxFlow Course: Principles and Applications of Flow Cytometry (Outros) Instituto de Medicina Molecular, Portugal
2017 - 2017 Concluded	Statistics for beginners (SPSS) by Isabel Flores (Outros) Instituto de Medicina Molecular, Portugal
2015 Concluded	Clinical Trials (Pós-Graduação) Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2014 Concluded	Integrated Master in Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal "BIOLOGIC-DRUG INTERACTIONS BETWEEN THERAPEUTIC PROTEINS AND SMALL-MOLECULE DRUGS" (THESIS/DISSERTATION)	17/20
2011 Concluded	Course of Medicines Pharmacovigilance & Safety, (Outros) Universidade de Lisboa Faculdade de Farmácia, Portugal

Affiliation

Science

	Category Host institution	Employer
2024/10/01 - Current	Contracted Researcher (Research)	Gulbenkian Institute for Molecular Medicine, Portugal

2022 - 2024/09/30	Contracted Researcher (Research)	Instituto de Medicina Molecular, Portugal

2017 - 2022/03	Researcher (Research)	Instituto de Medicina Molecular, Portugal

2017/09/01 - 2018/02/28	Visiting Researcher (Research)	Universitat Pompeu Fabra - Campus del Mar, Spain
	Universitat Pompeu Fabra - Campus del Mar, Spain
2016 - 2017	Researcher (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2016/09/01 - 2016/12/31	Research Trainee (Research)	CIC biomaGUNE, Spain
	CIC biomaGUNE, Spain
2012 - 2013	Research Trainee (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2011 - 2012	Research Trainee (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2024 - Current	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Medicina, Portugal

Projects

Grant

	Designation	Funders
2024/01 - Current	Development of an organ-on-a-chip of triple-negative breast cancer metastases for drug screening (TNBC-BM model) Pxxxxx Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes Ongoing
2022 - Current	Protecting the brain from metastatic breast cancer HR21-00605 Researcher Instituto de Medicina Molecular, Portugal	Obra Social La Caixa Ongoing
2024/10/01 - 2025/09/30	Development of new preclinical models of pediatric brain cancer – an effective and robust strategy to accelerate the development of new medicines NCH2024006 Principal investigator	Ongoing
2022/01/01 - 2025/01/31	Towards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier. PTDC/BTM-MAT/2472/2021 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	A molecular and nano approach to target the RANK-TRAF6 interface for bone metastases treatment PTDC/QUI-OUT/3854/2021 Co-Principal Investigator (Co-PI)	Fundação para a Ciência e a Tecnologia
2021/03/29 - 2024/03/29	TRESPASS2TREAT: A novel approach in pharmacotherapies for breast cancer patients with brain metastasis. PTDC/BIA-BQM/5027/2020 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia
2017 - 2019	INPACT- Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training, and communication 644167 Researcher Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2016/05/01 - 2020/02/29	Peptides for blood-brain barrier transmigration and drug delivery - novel therapies for the central nervous system PTDC/BBB-NAN/1578/2014 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Instituto de Medicina Molecular UID/BIM/50005/2019 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/03/01 - 2019/11/30	Nano sistemas para atacar selectivamente células estaminais do cancro colorectal e aumentar a sensibilidade a fármacos ENMed/0009/2015	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	André, Ana; Dias, Joana N. R.; Aguiar, Sandra; Moutinho, Isa; Carvalho, Jna; António, João; Cavaco, Marco; et al. "A novel rabbit VL single-domain antibody with versatile conjugation properties against canine lymphoma.". Paper presented in CIISA CONGRESS 2022, Lisboa, 2022. Published Vieira-da-Silva, Beatriz; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena; Cruz-Oliveira, Christine; Guida, Giuseppina; Valle, Javier; Cavaco, Marco; et al. "Anti-Zika virus and anti-Dengue virus peptide-porphyrin conjugates able to translocate the blood-brain and blood-placenta barriers – mechanism of action and pharmacokinetics". Paper presented in The Biochemistry Global Summit, 25th IUBMB Congress, 46th FEBS Congress, 15th PABMB Congress, Lisbon, Portugal, 2022. Published • 10.1002/2211-5463.13440 Cavaco, M. "A Methodology to predict peptide stability based on chemical properties". Paper presented in 17th Iberian Peptide Meeting, 2020. Cavaco, M; Gaspar, D; Valle, J; Andreu, D; Castanho, Miguel A. R. B.; Neves, V. "Brain metastases elimination with a peptide-conjugate". Paper presented in 5th Meeting of the Mind-Brain College of the University of Lisbon and 17th Meeting of Biomedical Engineering IST/FMUL, 2019. Cavaco, M; Gaspar, D; Frutos, S; Vila-Perelló, M; Andreu, D; Castanho, Miguel A. R. B.; Neves, V; Aguiar, S; Aires da Silva, F. "Overcoming the Blood-brain Barrier with peptide conjugates". Paper presented in Innovative approaches in targeted therapies: Brain, Infections and Cancer, 2018. Cavaco, M; Araujo, F; Fonseca, J Eurico; Goncalves, J. "SAT0046 TNF antagonist drug safety assessment by pharmacovigilance signaling and post-marketing adverse event reports". Paper presented in EULAR Congress 2017, 2017. 10.1136/annrheumdis-2017-eular.5884 Cavaco, M. "Trans-BBB peptides for targeting brain metastases". Paper presented in XI CAML PhD Meeting, 2017. Cavaco, M. "Solid Lipid Nanoparticles for the co-delivery of Drugs and siRNA". Paper presented in 8th iMED.ULisboa Postgraduate Students Meeting & 1st i3DU Students Meeting, 2016.
Conference poster	Martins, Sofia A. ; Rosa, Cátia; Cavaco, Marco; Andreu, David; Valle, Javier; Neves, Vera; Castanho, Miguel A. R. B.; Correia, João D. G.. "Disrupting the RANK-TRAF6 Interface: A Novel Approach for Bone Metastases Treatment". Paper presented in 37th European Peptide Symposium, 2024. Vieira-da-Silva, Beatriz; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena; Cruz-Oliveira, Christine; Guida, Giuseppina; Valle, Javier; Cavaco, Marco; et al. "Unravelling the factors that govern the ability of antiviral peptide-porphyrin conjugates to translocate the blood-brain barrier". Paper presented in the 18th Iberian Peptide Meeting, Sesimbra, Portugal, 2023. Martins, Sofia A.; Rosa, Cátia; Cavaco, Marco; Melo, Rita; Andreu, David; Valle, Javier; Neves, Vera; Castanho, Miguel A. R. B.; Correia, João D. G.. "Bone-Seeking Peptides Targeting the RANK-TRAF6 Interface for Bone Metastases Theranostics". Paper presented in XVIII Iberian Peptide Meeting, 2023. Simões, Beatriz T.; Chaparro, Catarina I. P.; Cavaco, Marco; Castanho, Miguel; Ramos-Cabrer, Pedro; Paula I. P. Soares; Neves, Vera. "Development of a nanoparticle for early diagnosis of Alzheimer's disease". Paper presented in 33rd European Society of Biomaterials Conference, Davos, Switzerland, 2023. Anikó Szecskó; Mária Mészáros; Gergo Porkoláb; Neves, Vera; Cavaco, Marco; Simões, Beatriz T.; Chaparro, Catarina I. P.; et al. Corresponding author: Anikó Szecskó. "Investigation of viral peph3 peptide-functionalized nanoparticles on a culture model of the blood-brain barrier". Paper presented in Hungarian Neuroscience Doctoral Conference, 2023. Leonardo, A; André, Ana; Aguiar, Sandra I; Nogueira, Sara; Cavaco, Marco; São Braz, Berta; Tavares, Luis; et al. "Development of Immunoliposomes with Dual-Targeting Against Canine B-Cell Lymphoma.". Paper presented in CIISA CONGRESS 2022 - Innovation in Animal, Veterinary and Biomedical Research, 2022. Cavaco, M. "Branched peptides for therapy of brain metastatic cancer". Paper presented in 25th IUBMB/46th FEBS/15th PABMB, Lisbon, Portuga, 2022. Cavaco, M. "Targeting brain metastasis with a selective and nontoxic dual-active peptide". Paper presented in Champalimaud Research Symposium, 2022. Cavaco, M. "The effect of different fluorophores on fluorescence-based techniques". Paper presented in 64th Annual Meeting of the Biophysical Society, San Diego, California, 2020. Cavaco, M. "Targeting brain metastases with a peptide conjugate". Paper presented in FEBS Congress, Krakow, Poland, 2019. Cavaco, M. "Targeting brain metastases with a peptide conjugate". Paper presented in XIII CAML PhD Students Meeting, Lisbon, Portugal, 2019. Cavaco, M. "Overcoming the Blood-brain Barrier with peptide conjugates". Paper presented in EMBO Workshop: Current advances in protein translocation across membranes, Sant Feliu, Spain, 2019. Cavaco, M. "Peptide-conjugate to target brain metastases". Paper presented in 3 rd Meeting of the College of Chemistry (3ECQUL), Lisbon, Portugal, 2018. Cavaco, M. "The Effect of Fluorophores on Peptide Properties". Paper presented in XII CAML PhD Students Meeting, Lisbon, Portugal, 2018. Cavaco, M. "TNF antagonist drug safety assessment by pharmacovigilance signaling and post-marketing adverse event reports". Paper presented in European Rheumatology Congress, 2017. Cavaco, M.; Cavaco, M. "Determination of Pesticide Residues in Ready-to-eat Lettuce Using QuEChERS Extraction and GC/MS". Paper presented in 2nd International Conference on Occupational and Environmental Toxicology, 2013.
Journal article	Simões, Beatriz T.; Chaparro, Catarina I. P.; Vieira, Tânia; Cavaco, Marco; Neves, Vera; Silva, Jorge Carvalho; Borges, João; Almeida, Filipe; Paula I. P. Soares. Corresponding author: Paula I. P. Soares. "Inhibition of nanoparticles uptake by melanoma cells improves magnetic hyperthermia in vitro". Communications Biology, Springer Nature (2024): Submitted Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Silva, Ruben D. M.; Gano, Lurdes; Correia, João D. G.; Andreu, David; Castanho, Miguel A. R. B.; Neves, Vera. "Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation". Fluids and Barriers of the CNS 21 1 (2024): http://dx.doi.org/10.1186/s12987-024-00545-5. Published • 10.1186/s12987-024-00545-5 Marco Cavaco; Clara Pérez-Peinado; Javier Valle; Ruben D.M. Silva; Lurdes Gano; João D.G. Correia; David Andreu; Miguel A.R.B. Castanho; Vera Neves. "The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis". Biomedicine & Pharmacotherapy (2024): https://doi.org/10.1016/j.biopha.2024.116573. 10.1016/j.biopha.2024.116573 Cherene, Milena Bellei; Cavaco, Marco Calvinho; Neves, Vera Luisa Santos; Castanho, Miguel Augusto Rico Botas; Taveira, Gabriel Bonan; Guimarães, Thomas Zacarone Afonso; de Oliveira Carvalho, André; et al. "Non-toxicity of Plant Candicidal Peptides for Mammalian Cell Lines and Galleria mellonella Model to Improving Selectivity for Clinical Use". International Journal of Peptide Research and Therapeutics 30 3 (2024): http://dx.doi.org/10.1007/s10989-024-10607-9. Published • 10.1007/s10989-024-10607-9 Susana A. Dias; Sandra N. Pinto; Ana S. Silva-Herdade; Marco Cavaco; Vera Neves; Luís Tavares; Manuela Oliveira; et al. "Quantitative Imaging of the Action of vCPP2319, an Antimicrobial Peptide from a Viral Scaffold, against Staphylococcus aureus Biofilms of a Clinical Isolate". ACS Infectious Diseases (2023): https://doi.org/10.1021/acsinfecdis.3c00195. 10.1021/acsinfecdis.3c00195 André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136. 10.3389/fvets.2023.1236136 Zandona, Antonio; Madunic, Josip; Miš, Katarina; Marakovic, Nikola; Dubois-Geoffroy, Pierre; Cavaco, Marco; Mišetic, Petra; et al. "Biological response and cell death signaling pathways modulated by tetrahydroisoquinoline-based aldoximes in human cells". Toxicology (2023): 153588. http://dx.doi.org/10.1016/j.tox.2023.153588. 10.1016/j.tox.2023.153588 Milena Bellei Cherene; Gabriel Bonan Taveira; Fabricio Almeida-Silva; Marciele Souza da Silva; Marco Calvinho Cavaco; André Teixeira da Silva-Ferreira; Jonas Enrique Aguilar Perales; et al. "Structural and Biochemical Characterization of Three Antimicrobial Peptides from Capsicum annuum L. var. annuum Leaves for Anti-Candida Use". Probiotics and Antimicrobial Proteins (2023): http://dx.doi.org/10.1007/s12602-023-10112-3. 10.1007/s12602-023-10112-3 Ana S. André; Joana N. R. Dias; Sandra Aguiar; Sara Nogueira; Pedro Bule; Joana Inês Carvalho; João P. M. António; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x. 10.1038/s41598-023-31568-x Cavaco, Marco; Castanho, Miguel A. R. B.; Neves, Vera. "The Use of Antibody-Antibiotic Conjugates to Fight Bacterial Infections". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.835677. 10.3389/fmicb.2022.835677 Filipa D. Oliveira; Marco Cavaco; Tiago N. Figueira; Javier Valle; Vera Neves; David Andreu; Diana Gaspar; Miguel A. R. B. Castanho. "The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics". The FEBS Journal 289 6 (2022): 1603-1624. https://doi.org/10.1111/febs.16247. 10.1111/febs.16247 Todorovski, Toni; Mendonça, Diogo A.; Fernandes-Siqueira, Lorena O.; Cruz-Oliveira, Christine; Guida, Giuseppina; Valle, Javier; Cavaco, Marco; et al. "Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates". Pharmaceutics 14 4 (2022): 738. http://dx.doi.org/10.3390/pharmaceutics14040738. 10.3390/pharmaceutics14040738 Bárbara B. Sousa; Rebelo de Almeida, Cátia; Ana Filipa Barahona Afonso; Lopes, Raquel; Ana Martins-Logrado; Cavaco, Marco; Neves, Vera; et al. "Selective inhibition of Brutons tyrosineyrosine kinase by a designed covalent ligand leads to potent therapeutic efficacy in blood cancers relative to clinically used inhibitors.". ACS Pharmacology and Translational Science (2022): 1-13. https://doi.org/10.1021/acsptsci.2c00163. Published • 10.1021/acsptsci.2c00163 Marco Cavaco; Silvia Frutos; Paula Oliete; Javier Valle; David Andreu; Miguel A. R. B. Castanho; Miquel Vila-Perelló; Vera Neves. "Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules". ACS Medicinal Chemistry Letters 12 11 (2021): 1663-1668. https://doi.org/10.1021/acsmedchemlett.1c00225. 10.1021/acsmedchemlett.1c00225 Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Andreu, David; Castanho, Miguel A. R. B.; Neves, Vera. "Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide". Pharmaceutics 13 11 (2021): 1863. http://dx.doi.org/10.3390/pharmaceutics13111863. 10.3390/pharmaceutics13111863 Aguiar, Sandra Isabel; Dias, Joana N. R.; André, Ana Santos; Silva, Marta Lisete; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; et al. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics 13 10 (2021): 1598. http://dx.doi.org/10.3390/pharmaceutics13101598. 10.3390/pharmaceutics13101598 Maria Gallo; Estefanía Moreno; Sira Defaus; Antonio Ortega-Alvaro; Angel Gonzalez; Patricia Robledo; Marco Cavaco; et al. "Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects". Journal of Medicinal Chemistry (2021): https://doi.org/10.1021/acs.jmedchem.1c00484. 10.1021/acs.jmedchem.1c00484 Diogo A. Mendonça; Mariët Bakker; Christine Cruz-Oliveira; Vera Neves; Maria Angeles Jiménez; Sira Defaus; Marco Cavaco; et al. "Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.1c00123. 10.1021/acs.bioconjchem.1c00123 Cavaco, Marco; Valle, Javier; Flores, Isabel; Andreu, David; A. R. B. Castanho, Miguel. "Estimating peptide half-life in serum from tunable, sequence-related physicochemical properties". Clinical and Translational Science 14 4 (2021): 1349-1358. http://dx.doi.org/10.1111/cts.12985. 10.1111/cts.12985 Marco Cavaco; David Andreu; Miguel A. R. B. Castanho. "The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization". Angewandte Chemie International Edition (2021): https://doi.org/10.1002/anie.202006372. 10.1002/anie.202006372 Ben Woods; Rúben D. M. Silva; Claudia Schmidt; Darren Wragg; Marco Cavaco; Vera Neves; Vera F. C. Ferreira; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00659. 10.1021/acs.bioconjchem.0c00659 Cavaco, M. "To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models". Frontiers in Bioengineering and Biotechnology (2020): http://dx.doi.org/10.3389/fbioe.2020.552035. 10.3389/fbioe.2020.552035 Marco Calvinho Cavaco; Javier Valle Garcia; Ruben Diogo Marques da Silva; João Domingos Galamba Correia; Miguel Augusto Rico Botas Castanho; David Andreu Martinez; Vera Luísa Santos Neves. "DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier". Current Pharmaceutical Design 26 (2020): https://doi.org/10.2174/1381612826666200213094556. 10.2174/1381612826666200213094556 Cavaco, Marco; Gaspar, Diana; Neves, Vera; Castanho, Miguel A.. "The Effect of Different Fluorophores on Fluorescence-Based Techniques". Biophysical Journal 118 3 (2020): 153a. http://dx.doi.org/10.1016/j.bpj.2019.11.953. 10.1016/j.bpj.2019.11.953 Cavaco, Marco; Gaspar, Diana; ARB Castanho, Miguel; Neves, Vera. "Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?". Pharmaceutics 12 1 (2020): 62. http://dx.doi.org/10.3390/pharmaceutics12010062. 10.3390/pharmaceutics12010062 Goncalves, J.; Santos, M.; Acurcio, R.; Iria, I.; Gouveia, L.; Matos Brito, P.; Catarina Cunha-Santos, A.; et al. "Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition". Alimentary Pharmacology & Therapeutics 48 5 (2018): 507-522. http://dx.doi.org/10.1111/apt.14808. 10.1111/apt.14808 Goncalves, J; Santos, M; Acurcio, R; Iria, I; Gouveia, L; Brito, P; Cunha Santos, A C; et al. "P545 Antigenic response to CT-P13 and remicade in inflammatory bowel disease patients shows similar epitope recognition". Journal of Crohn's and Colitis 12 supplement (2018): S381-S382. http://dx.doi.org/10.1093/ecco-jcc/jjx180.672. 10.1093/ecco-jcc/jjx180.672 Cavaco, Marco; Castanho, Miguel A. R. B.; Neves, Vera. "Peptibodies: An elegant solution for a long-standing problem". Peptide Science 110 1 (2018): e23095. http://dx.doi.org/10.1002/bip.23095. 10.1002/bip.23095 Cavaco, M; Goncalves, J. "Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims". Clinical Pharmacology & Therapeutics 102 4 (2017): 649-661. http://dx.doi.org/10.1002/cpt.605. 10.1002/cpt.605 Cavaco, Marco C.; Pereira, Carolina; Kreutzer, Bruna; Gouveia, Luis F.; Silva-Lima, Beatriz; Brito, Alexandra M.; Videira, Mafalda. "Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles". European Journal of Pharmaceutics and Biopharmaceutics 110 (2017): 76-84. http://dx.doi.org/10.1016/j.ejpb.2016.10.024. 10.1016/j.ejpb.2016.10.024 Goncalves, J.; Matos de Brito, P.; Batista, A.; Feio, J.; Machado, F.; Aperta, J.; Ascensão, I.; et al. "Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies". Journal of Clinical Pharmacy and Therapeutics 42 2 (2016): 239-243. http://dx.doi.org/10.1111/jcpt.12477. 10.1111/jcpt.12477
Thesis / Dissertation	"Trans-BBB peptides for targeting brain metastasis". PhD, Instituto de Medicina Molecular, 2022. Cavaco, Marco. "BIOLOGIC-DRUG INTERACTIONS BETWEEN THERAPEUTIC PROTEINS AND SMALL-MOLECULE DRUGS". Master, Universidade de Lisboa Faculdade de Farmácia, 2014.

Intellectual property

Patent

Cavaco, M; Neves, Vera; Castanho, Miguel A. R. B.. 2023. "Métodos para identificação de péptidos transportadores de barreira hematoencefálica".
Pending
Cavaco, M. 2019. "Peptide compounds for reducing side effects of CB1 receptor agonists".
Pending

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024	Design and study of new peptide-based protein-protein inhibitors to tackle triple-negative breast cancer via the suppression of the Wnt/ß-catenin pathway	37th European Peptide Symposium & 14th International Peptide Symposium (Florence, Italy)
2024	Tackling triple-negative breast cancer with new peptide-based protein-protein inhibitors via the suppression of the Wnt/ß-catenin pathway	FEBS3+ Meeting Exploring Molecular Frontiers (Pula, Croatia)
2023	Tratamento de metastases cerebrais com um péptido seletivo e não tóxico	5º Encontro Nacional de Jovens Investigadores em Oncologia
2023	The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	XVIII Iberian Peptide Meeting (Portugal)
2022	Targeting brain metastases with a dual active peptide	36th European and 12th International Peptide Symposium (Spain)
2021	The use of a selective and nontoxic dual-active peptide to eliminate brain metastasis	IV NeurULisboa
2020/05	Targeting brain metastases with a peptide conjugate	XIV CAML - IV NeurULisboa Instituto de medicina molecular João Lobo Antunes (Lisbon, Portugal)
2020/05	Targeting brain metastases with a peptide conjugate	XIV CAML PhD Students’ Meeting Instituto de medicina molecular João Lobo Antunes (Lisbon, Portugal)
2020/02	A Methodology to predict peptide stability based on chemical properties	XVII EPI (Madrid, Spain)
2019/07	Targeting brain metastases with a peptide conjugate	Youth FEBS Congress (Krakow, Poland)
2019	The use of peptides to eliminate brain metastasis	Pizza Seminar Instituto de medicina molecular João Lobo Antunes (Lisbon, Portugal)
2018/12	Overcoming the Blood-brain Barrier with peptide conjugates	Innovative approaches in targeted therapies: Brain, Infections and Cancer Instituto de medicina molecular João Lobo Antunes (Lisbon, Portugal)
2018/11	Brain metastases elimination with a peptide-conjugate	4th PhD Students Meeting of the Mind-Brain College Universidade de Lisboa (Lisbon, Portugal)
2017	Trans-BBB peptides for targeting brain metastases	XI CAML PhD Students’ Meeting Instituto de medicina molecular João Lobo Antunes (Lisbon, Portugal)
2016	Solid Lipid Nanoparticles for the co-delivery of Drugs and siRNA	8th iMED.ULisboa Postgraduate Students Meeting & 1st i3DU Students Meeting

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021 - Current	Anticancer activity of a minibody against triple negative breast cancer brain metastases Co-supervisor	Instituto de Medicina Molecular, Portugal
2023 - 2024	Design of peptide-based inhibitors to tackle triple-negative breast cancer Co-supervisor	Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023 - 2024	Cancer stem cell markers in triple-negative breast cancer, a comparison between patient biopsies and cancer cell models Co-supervisor	Master (Master) Universidade de Lisboa Faculdade de Medicina, Portugal
2023/02/20 - 2023/06/09	Traineeship Biomedical Laboratory Technology specialization Pharmaceutical and Biological Laboratory Technology Co-supervisor	BsC (Master) UC Leuven-Limburg, Belgium

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019 - 2019	Scientific committee - XIII IMM/CAML PhD Students Meeting (2019 - 2019) Congress (Member of the Scientific Committee)	Instituto de Medicina Molecular, Portugal
2018 - 2018	Scientific committee - Innovative approaches in targeted therapies: Brain, Infections and Cancer (2018 - 2018) Conference (Member of the Scientific Committee)	Instituto de Medicina Molecular, Portugal
2017 - 2017	Organising committee - 6th Iberian Peptide Meeting (16EPI) / 4th Chemical Biology Group Meeting (4GEQB) (2017) Congress (Member of the Organising Committee)	Universitat Pompeu Fabra - Campus del Mar, Spain
2016 - 2016	Scientific committee - 8th iMED.ULisboa Postgraduate Students Meeting & 1st i3DU Students Meeting (2016 - 2016) Conference (Member of the Scientific Committee)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023 - Current	Science communication activities - Breast Cancer Week Awareness	Breast Cancer Week Awareness
2024 - 2024	Science communication activities - Noite Europeia dos Investigadores Exhibition	Noite Europeia dos Investigadores
2024 - 2024	Science communication activities - Breast Cancer Week Awareness Exhibition	Breast Cancer Week Awareness
2023 - 2023	Science communication activities - Noite Europeia dos Investigadores Exhibition	Noite Europeia dos Investigadores
2021 - 2021	Science communication activities - World Antimicrobial Awareness Week Exhibition	World Antimicrobial Awareness Week
2020 - 2020	Science communication activities - World Environment Day Exhibition	World Environment Day
2019 - 2019	Science communication activities - Medical Biotechnology and Drug Development Course Exhibition	Medical Biotechnology and Drug Development Course
2019 - 2019	Science communication activities - International Day of Climate Action Exhibition	International Day of Climate Action
2019 - 2019	Science communication activities - Noite Europeia dos Investigadores Exhibition	Noite Europeia dos Investigadores
2018 - 2018	Science communication activities - Noite Europeia dos Investigadores Exhibition	Noite Europeia dos Investigadores

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024	Development of advanced cellular models for pre-clinical evaluation of anti-cancer (radio)therapy (Thesis) Main arguer	Margarida Cordeiro (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2024	Targeting the RANK-TRAF6 Axis: A molecular Approach (Thesis) Main arguer	Margarida Carreira (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023	The impact of MANF on skeletal muscle health and regeneration (Thesis) Main arguer	Linde Verbiest (Other) UC Leuven-Limburg, Belgium
2023	Avaliação pré-clínica de novas terapias anti-tumorais em modelos celulares 3D de cancro da mama (Thesis) Main arguer	Diogo Engrácia (Master) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2023	HIV-based vírus-like particles: design and evaluation as a targeted therapy tool (Thesis) Main arguer	Rafael Travassos (Master) Universidade Nova de Lisboa, Portugal
2022	Development of new molecular probes for imaging of cancer (Thesis) Main arguer	Afonso André Morais Belchior (Master) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2024 - Current	ACS Omega
2024 - Current	Antibodies
2024 - Current	Cancers
2024 - Current	Discover Medicine
2024 - Current	Discover Nano
2024 - Current	Frontiers in Immunology
2024 - Current	Fontiers of Oncology
2023 - Current	Scientific Reports
2023 - Current	Frontiers in Pharmacology
2023 - Current	Nutrients
2023 - Current	Journal of Cheminformatics
2023 - Current	ChemBioChem
2022 - Current	Biomedicines
2022 - Current	International Journal of Molecular Sciences
2022 - Current	Journal of Peptide Science
2022 - Current	Journal of Personalized Medicine
2022 - Current	Life
2022 - Current	Membranes
2022 - Current	PloS one
2022 - Current	Marine Drugs
2022 - Current	Vaccines
2022 - Current	Pharmaceutics
2022 - Current	Pharmaceuticals
2022 - Current	Oxygen
2022 - Current	Current issues in molecular biology
2022 - Current	Cells
2022 - Current	Bioconjugate Chemistry

Association member

	Society Organization name	Role
2019 - Current	Biophysical Society	Member
2019 - Current	Controlled Release Society	Member
2018 - Current	Antibody Society	Member
2017 - Current	Sociedade Portuguesa de Bioquimica	Member
2017 - Current	The European Peptide Society	Member
2014 - Current	Ordem dos Farmaceuticos	Member

Interview (tv / radio show)

	Program	Topic
2021 - 2021	Pura Vida Show	Breast Cancer metastization

Mentoring / Tutoring

	Topic	Student name
2024 - Current	ERASMUS student from Instituto de Productos Naturales y Agrobiología, Spain	Andrea Otazo
2024 - Current	ERASMUS student from Instituto de Productos Naturales y Agrobiología, Spain	Patricia Asensio
2023 - Current	Visiting PhD student from Universität Regensburg, Germany	Albert Gattor
2022 - Current	Master student	Rodrigo Alarcão
2021/01/01 - Current	PhD student	Ruben Silva
2021 - Current	PhD student	Catarina Gonçalves
2019/01/01 - Current	PhD student	Catarina Chaparro
2023 - 2023	Visiting medical student from the Faculty of Medicine	Ana Carolina
2023 - 2023	ERASMUS student from University of Zagreb, Croatia	Lucija Marcelic
2023 - 2023	Visiting PhD student from Queensland University of Technology, Australia	Henry Lamb
2022 - 2023	Visiting PhD student from Universidade Estadual do Norte Fluminense Darcy Ribeiro	Milena Cherene
2021 - 2021	Visiting PhD student from Institute for Medical Research and Occupational HeaIth (IMROH), Zagreb, Croatia	António Zandona
2020 - 2021	Master student	Patricia Fraga
2019 - 2019	Visiting PhD student from University Pompeu Fabra, Spain	Maria Gallo
2018 - 2019	Master student	Abeda Ahmad
2018 - 2018	Visiting medical student from the Faculty of Medicine	Francisco Alves

Distinctions

Award

2019	Best oral presentation (3rd place)
2018	Best poster presentation (2nd place)
2013	Gilead Pharmaceutical Biotechnology Award Gilead Sciences Lda, Portugal
2011	Research Scholarship Fundação Amadeu Dias Grant, Portugal