Filipa Fernandes Mendes (1711-EA6A-041A)

Curriculum Vitae

Filipa Fernandes Mendes

Filipa Fernandes Mendes is a Principal Researcher (with tenure) at Universidade de Lisboa, Instituto Superior Técnico, Department of Nuclear Sciences and Engineering. Her scientific activity is developed at C2TN - Center for Nuclear Sciences and Technologies, where she is currently the Coordinator of the thematic strand "Radiopharmaceutical Sciences and Health Physics" and a member of the Coordinating Commission of the Scientific Council (CC-CC). She was a Visiting Professor at the Technical University of Munich, Germany, in the summer of 2023. Filipa Mendes is focused on merging advances in molecular biology with chemistry (radiopharmaceutical and medicinal) to advance molecular and biomedical imaging and therapy. Given her training and experience in molecular and cellular biology, present research interests are the understanding of the biological mechanisms and molecular interactions of radioactive compounds useful as probes for in vivo molecular imaging and/or targeted radiotherapy. She has extended the evaluation of cancer theranostic compounds (suitable for diagnosis and therapy) to 3D cellular models of cancer, and she was the Editor of a Research Topic on the journal Frontiers in Molecular Biosciences on this subject. Moreover, she is interested in the development of novel molecular tools for the study of ABC transporters involved in human diseases, such as Cystic Fibrosis and Cancer Multidrug Resistance. Since 2023 she is a member of the steering comitee of the European Working Group on Radiobiology of Molecular Radionuclide Therapy. She is the author of 74 articles in peer-reviewed journals (90% in Q1), 24 of which as senior author. She has over 1880 citations (H index 25 and i10 index 52) and was/is the PI of 4 FCT funded projects (including 1 Bilateral with France and 1 FCT-UTAustin) and 1 industry research contract. Filipa Mendes has supervised 8 MSc and 1 PhD to completion and currently supervises/co-supervises 2 MSc and 6 PhD students. Since 2014 she teaches at the Department of Bioengineering, Instituto Superior Técnico, the courses Genetic Engineering and Molecular Biotechnology, and she has received several Excellence in Teaching diplomas.

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Identification

Personal identification

Full name: Filipa Fernandes Mendes

Citation names

Mendes, Filipa

Author identifiers

Ciência ID: 1711-EA6A-041A
ORCID iD: 0000-0003-0646-1687
Researcher Id: B-2057-2010
Scopus Author Id: 36465350400

Email addresses

fmendes@ctn.tecnico.ulisboa.pt (Professional)

Addresses

C2TN- Centro Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Professional)
DECN- Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Professional)

Websites

https://c2tn.tecnico.ulisboa.pt/radiopharmaceutical-sciences-rs/ (Professional)
https://fenix.tecnico.ulisboa.pt/homepage/ist25493 (Scholar)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Elementary (A2)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)	Beginner (A1)

Education

	Degree	Classification
2023/09 - 2023/09 Concluded	FELASA B - Animal experimentation course - (function A Diretive 2010/63/EU) (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/07 - 2020/09/18 Concluded	Gestão de equipas / Team management (Outros) Companhia Própria - Formação e Consultoria, Portugal	na
2008 - 2008 Concluded	Edição e Revisão de texto / Text Edition and Revision (Diploma de especialização) Universidade Católica Portuguesa, Portugal
2000 - 2004 Concluded	Biologia / Biology (Doutoramento) Major in Biologia Celular / Cell Biology Universidade de Lisboa Faculdade de Ciências, Portugal "Expression, Localization and Traffic of Wild-Type and Mutant CFTR Protein" (THESIS/DISSERTATION)	PhD Summa cum laude (Aprovada com distinção e louvor)
1994 - 1999 Concluded	Biologia - Biologia Microbiana e Genética / Biology - Microbiology and Genetics (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Cystic fibrosis: Expression and Intracellular localization of CFTR protein" (THESIS/DISSERTATION)	18

Affiliation

Science

	Category Host institution	Employer
2023/02/01 - Current	Principal Investigator (Research)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/06/11 - 2023/07/29	Principal Investigator (Research)	Technical University of Munich, Germany, Germany
	Technical University of Munich, Germany, Germany
2016/01/01 - 2023/01/31	Auxiliary Researcher (Research)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Departamento de Engenharia e Ciências Nucleares, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2013/09/01 - 2015/12	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal

2014/02/17 - 2014/06/30	Invited Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Ciências, Portugal
	Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2008/04/01 - 2012/05/01	Invited Assistant Professor (University Teacher)	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Positions / Appointments

	Category Host institution	Employer
2021/04 - Current	Coordinator of the Health Thematic Line, C2TN Research Unit	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2021/04 - Current	Member of the Coordinating Council, C2TN Research Unit	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Others

	Category Host institution	Employer
2013/09/01 - 2015/12/31	Principal Investigator – “FCT Investigator” Development Grant (Life and Health Sciences)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2008/09/01 - 2013/08/31	Research Scientist - Ciência 2007	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

2005/01/01 - 2008/07/01	Post-doctoral Fellow	Universidade de Lisboa Faculdade de Ciências, Portugal

2000/01/01 - 2004/12/31	PhD Student	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

2001/05/01 - 2003/08/31	Visiting Graduate Student	University of Virginia Department of Biology, United States

1998/09/01 - 1999/07/30	Undergraduate Trainee	Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Projects

Contract

	Designation	Funders
2023/09 - 2028/11	Improved 177Lu radioconjugates for Prostate Cancer Theranostics - development and evaluation in advanced cellular models IAEA CRP F-22078 Principal investigator International Atomic Energy Agency, Austria	International Atomic Energy Agency Ongoing
2024/03 - 2025/04	Personalized 3D Tumor models for Precision RadioTheranostics of Glioblastoma 2022.15449.UTA -FCT UT Austin Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2021/04 - 2025/03	A novel nanoplatform for melanoma targeting with hydroxyquinoline metal complexes PTDC/QUI-QIN/0586/2020 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2019/01 - 2024/12	Centro de Ciências e Tecnologias Nucleares 154716UID	Fundação para a Ciência e a Tecnologia
2021/03/01 - 2024/11	Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer PTDC/QUI-QIN/0146/2020 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2022/03 - 2024/08	Targeted radiotherapy of radioresistant cancers: a radiobiological study with advanced cell models 2021.09137.CBM Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2021/01 - 2023/12	Organelle-targeted Radiocomplexes for Auger Therapy of Cancer PTDC/MED-QUI/1554/2020	Fundação para a Ciência e a Tecnologia
2022/04 - 2023/06	Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer 175166PRJ Researcher	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/06	In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy LISBOA-01-0247-FEDER-045904 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09/01 - 2022/07/31	Targeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach PTDC/QUI-NUC/30147/2017- FCT Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/08/01 - 2022/07/31	Novel Molecular Imaging tools for Cystic Fibrosis PTDC/BTM-TEC/29256/2017 Principal investigator Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2015/04 - 2018	Validation of novel tools for detection of CFTR CF antibodies Principal investigator Universidade de Lisboa Instituto Superior Técnico, Portugal	ProQR Therapeutics NV Concluded
2013/06 - 2016/05	Molecular and Nano Tools for Cancer Theranostics 126789 Provided by PTCRIS: 126789 Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03	Dual Targeting Strategy for EGFR Positive Tumors 134975 Provided by PTCRIS: 134975 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2012/03 - 2015/02	Preclinical evaluation of ruthenium potential drugs for cancer therapy info:eu-repo/grantAgreement/FCT/3599-PPCDT/118077/PT Researcher Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	Functional metal complexes that bind to biomolecules COST Action CM1105 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Concluded
2012 - 2015	Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study PTDC/QUI-QUI/121752/2010 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/03 - 2014/08	Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes Provided by PTCRIS: 114139 114139 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2013/07 - 2014/06	A Molecular Imaging Approach to Cystic Fibrosis 124308 Provided by PTCRIS: 124308 Principal investigator Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluded
2012 - 2014	Target-specific and Heterobimetallic Platinum Complexes: Synthesis, Characterization and Mechanistic Studies E-23/12 Researcher Universidade de Lisboa Faculdade de Ciências, Portugal	Concluded
2010 - 2012	Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation PTDC/QUI-QUI/102049/2008 Researcher Centro de Ciências e Tecnologias Nucleares, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2010	Metallo-drug design and action COST Action D39 Researcher
2007 - 2008	A novel insight into CFTR Phosphorylation: implications for its processing, trafficking and function PTDC/BIA-BCM/67058/2006 Researcher Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2008	Novel post-genomic cell-based screens for drug targeting in membrane protein disorders- TargetScreen2 EU FP6-LSH-2005-037365 Post-doc Universidade de Lisboa Faculdade de Ciências, Portugal	European Commission Sixth Framework Programme Concluded
2002 - 2004	In search of new molecular targets for the development of novel therapeutic strategies for cystic fibrosis POCTI/MGI/40878/2001 Other Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2000 - 2003	Thematic Network around Cystic Fibrosis and Related Diseases EU FP5-QLK3-1999-00241	European Commission Sixth Framework Programme
2001/02/01 - 2002	Biogenesis and function of CFTR protein with different mutations: molecular basis for clinical and therapeutic heterogeneity of Cystic Fibrosis? info:eu-repo/grantAgreement/FCT/POCI/35737/PT Other Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluded
1999 - 1999	Cystic Fibrosis - traffic and cellular function of CFTR PRAXIS/PSAU/C/SAU/55/96	Fundação para a Ciência e a Tecnologia

Outputs

Publications

Book chapter	Catarina Pinto; Joana Guerreiro; Silva, Francisco; Mendes, Filipa; António Rocha Paulo. "Radiopharmaceuticals for molecular imaging and theranostics of gliobastoma". In New Insights Into Gliobastoma: Diagnosis, Therapeutics and Theranostics, 667-705. Academic Press, 2023. Published Matos, M; Mendes, Filipa; Valente, A.; Morais, T.S.; Zinck, P; Garcia, MH; Bicho, M.; Marques, F. "Ruthenium-based anticancer compounds: insights into their cellular targeting and mechanism of action". In Ruthenium Complexes - Photochemical and Biomedical Applications, edited by Alvin A. Holder; Jimmie L. Bullock; Welsey R. Browne; Mark A. LAwrence; Lothar Lilge. Wiley-VCH Verlag, 2017.
Conference abstract	Fernandes, Célia; Santos, Joana F.; M. T. Braz; F. Silva; PD Raposinho; J. F. Guerreiro; F. Cleeren; et al. "Mitochondrion-Tropic Radioconjugates Carrying TPP and PSMA Derivatives: Radiobiological and Imaging Studies in Prostate Cancer Models". Paper presented in World Molecular Imaging Congress 2022, Miami, 2022. Published Célia Fernandes; Santos JF; Braz MT; Silva, Francisco; PD Raposinho; Guerreiro JF; Cleeren, Frederik; et al. "Mitochondria-targeted Radiocomplexes for Cancer Theranostics". Paper presented in TERACHEM - The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, 2022. Published Ferreira, VFC; Guerreiro JF; Correia JG; Gonçalves J; Farinha CM; Mendes F. Corresponding author: Mendes F. "Development of molecular imaging tools to monitor drug efficacy through assessment of CFTR localization in vivo". Paper presented in North American Cystic Fibrosis Conference, 2021. Published Gano, Maria Lurdes; Vultos, F.; Fernandes, Célia; Mendes, Filipa; Correia, JDG. "Biological evaluation of radiolabelled peptides for oestrogen positive tumour theranostics". Paper presented in Annual Congress of the European Association of Nuclear Medicine October, Barcelona, 2019. Published Vultos, F.; Célia Fernandes; Mendes, Filipa; Correia, JDG; Gano, Maria Lurdes. "Indium (III) Complex with a bifunctional agent for dual targeting of cancer cells". Paper presented in Terachem 2018 – 3rd International symposium on Technetium and Other Radiometals in Chemistry and Medicine, bressanone, 2019. Published Vultos, F.; Belo M; Scheepstra M; Francisco Silva; Fernandes, Célia; C. Oliveira; Mendes, Filipa; et al. "Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics". Paper presented in ESRR’18 – 19th European Symposium on Radiopharmacy and Radiopharmaceuticals,, Groningen, 2018. Published Pereira, EL ; Paulo, António; C. Oliveira; Mendes, Filipa; PD Raposinho; Belchior A ; Correia, Isabel M. ; Lavrado J. Corresponding author: Pereira, EL. "Radioiodinated compounds for Auger therapy". Paper presented in 29th¿Annual EANM Congress - EANM’16, barcelona, 2016. Published Mendes, Filipa; Oliveira, Bruno L.; Morais, Mauricio; Raposinho, P.D.; Correia, JDG. "Radiometallated L-arginine derivatives for imaging nitric oxide synthase in vivo". Paper presented in 33rd European Peptide Symposium, Sofia, 2014. Published Ferreira, VFC; Oliveira, BL; Correia, JDG; Santos, I.; Farinha, CMF; Mendes, Filipa. "Cystic Fibrosis: new molecular imaging tools". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Published Paulo, A.; Rodrigues, I.; Campello, M.P.C.; Morais, G.; Ferreira, VFC; Mendes, Filipa; Santos, I.; Gama, S.. "DNA Binding and Cytotoxic Activity of Zn(II) and Cu(II) Complexes with New Bis(thiosemicarbazone) Derivatives". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Published Rodrigues, I.; Mendes, Filipa; Palma, E.; Correia, I.; Carvalho, MF; Cordeiro Dos Santos, I.; Marques, F.; et al. "New Mixed-Ligand Cu(II) Complexes Acting as “Self-activating” Chemical Nucleases". Paper presented in 12th European Biological Inorganic Chemistry Conference, Zurich, 2014. Published Neto, C.; Oliveira, MC; Fernandes, C.; Gano, Lurdes; Mendes, Filipa; Kniess, T.; Santos, I.. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Paper presented in 19th International Symposium on Radiopharmaceutical Sciences, 2011. Published Mendes, Filipa; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". Paper presented in Annual Congress of the EANM, Vienna, 2010. Published Gano, Lurdes; Mendes, Filipa; Fernandes, C.; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Paper presented in 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010. Published Li, H.; Yang, W.; Mendes, Filipa; Amaral, MD; Sheppard, DN. "Renal cyst formation as tool for CFTR research". Paper presented in 31st European Cystic Fibrosis Conference, 2008. Published • 10.2118/4789-ms Dahimène S; Luz, S.; Mendes, Filipa; Almaça, J.; Barro-Soria, R.; Kunzelmann, K.; Amaral, MD. "Novel cellular models to identify rescuing of F508del-CFTR trafficking defect". Paper presented in 22nd Annual North American Cystic Fibrosis Conference, 2008. Published Mendes, Filipa; Vieira, I.; Alves, PC; Farinha, CMF; Amaral, MD. "Role of Bag-1 on the turnover and processing of wild-type and F508del-CFTR". Paper presented in 20th Annual North American Cystic Fibrosis Conference, Denver, 2006. Published Farinha, CMF; Mendes, Filipa; Roxo-Rosa, M.; Amaral, MD. "Low Temperature Studies Suggest Conformational Differences Between Wild-Type and F508del-CFTR". Paper presented in 20th Annual North American Cystic Fibrosis Conference, Denver, 2006. Published Ramalho, AS; Farinha, CMF; Mendes, Filipa; Neto, M.; Amaral, MD. "Lack of N-terminus causes major impairment on CFTR processing but does not abolish function". Paper presented in 19th Annual North American Cystic Fibrosis Conference, Baltimore, 2005. Published Mendes, Filipa; Wakefield, J.; Amaral, MD; Bebok, Z.; Penque, D.. "Characterization of a New Polarized Epithelial Cell Model to Study CFTR". Paper presented in 18th Annual North American Cystic Fibrosis Conference, Saint Louis, 2004. Published Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Effect of R555K or G550E traffic restoring substitutions upon A561E-CFTR processing". Paper presented in 25th Congress ECFS, 2002. Published Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Misprocessing of A561E-CFTR is partially corrected by R555K or G550E traffic Restoring Substitutions". Paper presented in 15th Annual North American Cystic Fibrosis Conference, Orlando, 2001. Published Mendes, Filipa; Penque, D.; Barroso, M.. "A Polarized Epithelial Cell Model to Study the Membrane Traffic of the Cystic Fibrosis Transmembrane Conductance Regulator". Paper presented in 2001 Annual ASCB Meeting, Washington, 2001. Published
Conference paper	Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas". 2021. 10.22323/1.380.0040 Di Maria S; Belchior, A.; Pereira, Edgar; Do Quental, L.; Oliveira, MC; Mendes, Filipa; Lavrado, J.; Paulo, António; Vaz, P.. "Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies". 2017. Published • 10.1016/j.radphyschem.2017.01.028 Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". Paper presented in CARDIOTECHNIX 2013 - International Congress on Cardiovascular Technologies, Vilamoura, 2013. Published
Journal article	Alexandra Martins; Brigida C. Ferreira; Maria Manuela Gaspar; Sandra Vieira; Joana Lopes; Ana S. Viana; António Paulo; et al. "Enhanced Cytotoxicity against a Pancreatic Cancer Cell Line Combining Radiation and Gold Nanoparticles". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16070900. 10.3390/pharmaceutics16070900 Catarina I. G. Pinto; André D. M. Branco; Bucar, Sara; Alexandra Fonseca; Abrunhosa, Antero J.; Lobato da Silva, Claúdia ; Guerreiro, JF; Mendes, Filipa. Corresponding author: Mendes, Filipa. "Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids". European Journal of Nuclear Medicine and Molecular Imaging Research na na (2024): na-na. Open access • Accepted Antunes, Joana; Pinto, Catarina Isabel; Campello, Maria Paula; Santos, Pedro; Mendes, Filipa; Paulo, António; Sampaio, Jorge Miguel. "Utility of realistic microscopy-based cell models in simulation studies of nanoparticle-enhanced photon radiotherapy". Biomedical Physics & Engineering Express (2024): http://dx.doi.org/10.1088/2057-1976/ad2020. 10.1088/2057-1976/ad2020 Joana F. Santos; Maria T. Braz; Paula Raposinho; Frederik Cleeren; Irwin Cassells; Simon Leekens; Christopher Cawthorne; et al. "Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier". Molecular Pharmaceutics (2024): https://doi.org/10.1021/acs.molpharmaceut.3c00787. 10.1021/acs.molpharmaceut.3c00787 João Franco Machado; Marco Sá; Inês Pires; Miguel Tarita da Silva; Fernanda Marques; Jaime A. S. Coelho; Filipa Mendes; et al. "Dual FGFR-targeting and pH-activatable ruthenium–peptide conjugates for targeted therapy of breast cancer". Dalton Transactions (2024): https://doi.org/10.1039/D4DT00497C. 10.1039/D4DT00497C Barracosa, Bruno; Felício, João; Carvalho, Ana; Moreira, Leonilde M.; Mendes, Filipa; Verde, Sandra Cabo; Pinto-Varela, Tânia. "Decision support tool to define the optimal pool testing strategy for SARS-CoV-2". Decision Support Systems 175 (2023): 114046. http://dx.doi.org/10.1016/j.dss.2023.114046. 10.1016/j.dss.2023.114046 Diogo M. Engrácia; Catarina I. G. Pinto; Filipa Mendes. "Cancer 3D Models for Metallodrug Preclinical Testing". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511915. 10.3390/ijms241511915 Leonor Côrte-Real; Vivien Pósa; Matilde Martins; Raquel Colucas; Nóra V. May; Xavier Fontrodona; Isabel Romero; et al. "Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential". Inorganic Chemistry (2023): https://doi.org/10.1021/acs.inorgchem.3c01066. 10.1021/acs.inorgchem.3c01066 Leitao, Renan C.F.; Silva, Francisco; Ribeiro, Gabriel H.; Santos, Isabel C.; Guerreiro, Joana F.; Mendes, Filipa; Batista, Alzir A.; et al. "Gallium and indium complexes with isoniazid-derived ligands: Interaction with biomolecules and biological activity against cancer cells and Mycobacterium tuberculosis". Journal of Inorganic Biochemistry 240 (2023): 112091. http://dx.doi.org/10.1016/j.jinorgbio.2022.112091. 10.1016/j.jinorgbio.2022.112091 Carina Marques Coelho; Lia Pereira; Pamela Teubig; Pedro Santos; Filipa Mendes; Sílvia Viñals; Daniel Galaviz; Federico Herrera. "Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232012265. 10.3390/ijms232012265 Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925. 10.1016/j.ijpharm.2022.121925 Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences 23 13 (2022): 7238-7238. https://doi.org/10.3390/ijms23137238. 10.3390/ijms23137238 Ana B. Buades; Laura C. J. Pereira; Bruno J. C. Vieira; Ana C. Cerdeira; João C. Waerenborgh; Teresa Pinheiro; António P. A. Matos; et al. "The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]-): a glance into the potential of a low-dose approach for glioblastoma radiotherapy". Inorganic Chemistry Frontiers (2022): https://doi.org/10.1039/D1QI01513C. 10.1039/D1QI01513C Nuez-Martínez, Miquel; Queralt-Martín, María; Muñoz-Juan, Amanda; Aguilella, Vicente M.; Laromaine, Anna; Teixidor, Francesc; Viñas, Clara; et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma". Journal of Materials Chemistry B 10 47 (2022): 9794-9815. http://dx.doi.org/10.1039/d2tb01818g. 10.1039/d2tb01818g Miquel Nuez-Martinez; Catarina I. G. Pinto; Joana F. Guerreiro; Filipa Mendes; Fernanda Marques; Amanda Muñoz-Juan; Jewel Ann Maria Xavier; et al. "Cobaltabis(dicarbollide) ([o-COSAN]-) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma". 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Organic and Biomolecular Chemistry 8 18 (2010): 4104-4116. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955948795&partnerID=MN8TOARS. 10.1039/c0ob00073f Ramalho, A.S.; Lewandowska, M.A.; Farinha, C.M.; Mendes, F.; Gonçalves, J.; Barreto, C.; Harris, A.; Amaral, M.D.. "Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients". Cellular Physiology and Biochemistry 24 5-6 (2009): 335-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450231758&partnerID=MN8TOARS. 10.1159/000257426 Schmidt, A.; Hughes, L.K.; Cai, Z.; Mendes, F.; Li, H.; Sheppard, D.N.; Amaral, M.D.. "Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator". British Journal of Pharmacology 153 6 (2008): 1311-1323. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349033879&partnerID=MN8TOARS. 10.1038/sj.bjp.0707663 Mendes, F.; Wakefield, J.; Bachhuber, T.; Barroso, M.; Bebok, Z.; Penque, D.; Kunzelmann, K.; Amaral, M.D.. "Establishment and characterization of a novel polarized MDCK epithelial cellular model for CFTR studies". Cellular Physiology and Biochemistry 16 4-6 (2005): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-27844525431&partnerID=MN8TOARS. 10.1159/000089857 Mendes, F.; Farinha, C.M.; Roxo-Rosa, M.; Fanen, P.; Edelman, A.; Dormer, R.; McPherson, M.; et al. "Antibodies for CFTR studies". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 69-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944369736&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.016 Harris, C.M.; Mendes, F.; Dragomir, A.; Doull, I.J.M.; Carvalho-Oliveira, I.; Bebok, Z.; Clancy, J.P.; et al. "Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 43-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944385576&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.009 Mendes, F.; Doucet, L.; Hinzpeter, A.; Féree, C.; Lipecka, J.; Fritsch, J.; Edelman, A.; et al. "Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures". Journal of Cystic Fibrosis 3 SUPPL. 2 (2004): 37-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944422399&partnerID=MN8TOARS. 10.1016/j.jcf.2004.05.008 Farinha, C.M.; Mendes, F.; Roxo-Rosa, M.; Penque, D.; Amaral, M.D.. "A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein". Molecular and Cellular Probes 18 4 (2004): 235-242. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242674336&partnerID=MN8TOARS. 10.1016/j.mcp.2004.03.005 Mendes, F.; Rosa, M.R.; Dragomir, A.; Farinha, C.M.; Roomans, G.M.; Amaral, M.D.; Penque, D.. "Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein". Biochemical and Biophysical Research Communications 311 3 (2003): 665-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242577536&partnerID=MN8TOARS. 10.1016/j.bbrc.2003.10.048 Doucet, L.; Mendes, F.; Montier, T.; Delépine, P.; Penque, D.; Férec, C.; Amaral, M.D.. "Applicability of different antibodies for the immunohistochemical localization of CFTR in respiratory and intestinal tissues of human and murine origin". Journal of Histochemistry and Cytochemistry 51 9 (2003): 1191-1199. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041819843&partnerID=MN8TOARS. Farinha, C.M.; Nogueira, P.; Mendes, F.; Penque, D.; Amaral, M.D.. "The human Dnaj homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70". Biochemical Journal 366 3 (2002): 797-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037106481&partnerID=MN8TOARS. 10.1042/BJ20011717 Zaman, K.; McPherson, M.; Vaughan, J.; Hunt, J.; Mendes, F.; Gaston, B.; Palmer, L.A.. "S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation". Biochemical and Biophysical Research Communications 284 1 (2001): 65-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034804969&partnerID=MN8TOARS. 10.1006/bbrc.2001.4935 Penque, D.; Mendes, F.; Beck, S.; Farinha, C.; Pacheco, P.; Nogueira, P.; Lavinha, J.; Malhó, R.; Amaral, M.D.. "Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells". Laboratory Investigation 80 6 (2000): 857-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033918281&partnerID=MN8TOARS.

Intellectual property

Patent

Garcia, MH; Morais, T.S.; Tomaz AI; Marques F; Mendes, Filipa. 2013. "Transition metal complexes for pharmaceutical applications".
Granted/Issued
Amaral, MD; Dahimène S; Mendes, Filipa. 2011. "Two novel human epithelial cell lines to be used in assays for traffic studies/ screens of CFTR protein (wild-type and with the F508del mutation". Portugal.
Pending

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09	Evaluation of the therapeutic potential of 64CuCl2 in 3D models of glioblastoma	10th international symposium on physical, molecular, cellular, and medical aspects of Auger electron processes (Montpellier, France)
2023/07	Biological evaluation of 64CuCl2 as a promising tool for cancer theranostics	Invited talk Department of Pharmaceutical and Pharmacological Sciences, KU Leuven (Leuven, Belgium)
2023/06	Radiopharmaceutical Sciences Research at C2TN	Invited talk at the Chair of Radiopharmaceutical Chemistry Technical University of Munich (Munich , Germany)
2023/03	Radiopharmaceuticals and Theranostics - basic concepts and (pre)clinical examples	Workshop “ New Approaches in Cancer (Radio)theranostics" Department of Life Sciences, University of Coimbra (Coimbra , Portugal)
2023/03	No Longer Flat: 3D Models of Cancer for Evaluation of Metallodrugs	Symposium “Metals...and Beyond: the next 50 years" Technical University of Munich (Raitenhaslach, Germany)
2022/11	Preclinical Evaluation of Radiopharmaceuticals	PRISMAP young scientists’ event PRISMAP project (EU Horizon 2020) (Padova, Italy)
2022/07	Nano-particle research at C2TN - Update on the Biological Studies within TPPT	Nanoparticle Research Workshop Proton Therapy Center, MD Anderson Cancer Center, University of Texas, Houston (Houston, United States)
2022/07	TOF-PET FOR PROTON THERAPY (TPPT)- an update of the biological studies	Invited talk Department of Physics Department of Physics, University Texas Austin (Austin, United States)
2021/10	Innovative agents for Nuclear Imaging and/or Systemic Radiotherapy of cancer	Webinar - A Universidade de Lisboa à Procura de Respostas para o Cancro Oncology working group, Rede Saúde da Universidade de Lisboa (Lisboa, Portugal)
2021/09	Health and Environment Research Areas at C2TN	First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies)
2019/09/12	Assessment of CFTR localization in vivo to monitor efficacy of CFTR correctors	Invited Talk - REAP Expert Meeeting European Cystic Fibrosis Society (ECFS) (Lisboa, Portugal)
2019/09	New insights on the radiobiological effects of 64CuCl2 - a simple tool for prostate cancer theranostics	I NOVA Biophysica Internacional Conference (Lisboa, Portugal)
2019/03	Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe	16th European Cystic Fibrosis Basic Science Conference European Cystic Fibrosis Society (Dubrovnik, Croatia)
2018/06	Molecular and Cell Biology methods for validation of (imaging) biomarkers	Summer School “Development and Pre-clinical Evaluation of Radiopharmaceuticals” Marie Curie Innovative Training Network "MEDICIS-Promed" (Cascais, Portugal)
2017/11	Ionizing radiation and health: Imaging and exposure biomarkers	Physics Department seminars Physics Departmentm, IST (Lisboa, Portugal)
2014/08	Molecular Imaging probes for in vivo detection of the Cystic Fibrosis Protein	2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules COST Action CM1105 (Zurich, Switzerland)
2014/05	Biological relevance and general applications of peptides	Training School “Peptides for Targeted Drug Delivery" COST Action CM1105“Functional metal complexes that bind to biomolecules” (Bobadela LRS, Portugal)
2014/04	Biomarkers for the Theranostic Strategy - Cancer and Molecular Theranostics	Expert meeting COST action CM1105 (Bobadela LRS, Portugal)
2013/10	New Platinum (II) complexes with DNA-targeting ability	1st Meeting on Functional metal complexes that bind to biomolecules COST ACTION CM1105 (Barcelona, Spain)
2013/09	Perfusion and specific radioprobes for cardiac imaging	Cardiotecnhix International Congress on Cardiovascular Technologies Cardiotecnhix (Vilamoura, Portugal)
2012/12	Imaging in the era of molecular oncology: new probes for detection of multidrug resistance	Bioengineering Department Seminars IST (Lisboa, Portugal)
2012/12	Sondas para Imagiologia Cardiovascular	Workshop “Biomarcadores sanguíneos e imagiologia da placa aterosclerótica” Instituto Superior Técnico (Sacavém, Portugal)
2012/10	From cardiology to oncology: new radioactive probes for detection of cancer multidrug resistance	Chem Forum -Autumn Edition IST (Lisboa, Portugal)
2008/12	Pharmacogenomics – contribute for cancer therapeutics	Symposium Cancer and Therapeutic Approaches Universidade Lusófona de Humanidades e Tecnologias (Lisboa, Portugal)
2007	An approach to chaperone therapy: correcting the basic defect in Cystic Fibrosis	V International Symposium Sociedade Portuguesa de Doenças Metabólicas Sociedade Portuguesa de Doenças Metabólicas (Porto, Portugal)
2007	Role of Bag-1 in turnover and processing of wild-type and F508del-CFTR	Workshop Proteins in Health and Disease: from structure to function Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2006	Modulation of CFTR biosynthesis and maturation by molecular chaperones: implications for Cystic Fibrosis	Dia do Jovem Investigador do Instituto Ricardo Jorge Instituto Ricardo Jorge (Lisboa, Portugal)
2004	Characterization of a New Polarized Epithelial Cell Model to Study the Cystic Fibrosis Transmembrane Conductance Regulator	New Frontiers in the Basic Science of Cystic Fibrosis European Cystic Fibrosis Society (Tomar, Portugal)
1999	Imunolocalização da proteína F508del-CFTR na região apical de células epiteliais nasais	XXXIV Reun Ann Soc Port Mic Electr e Biol Cel Sociedade Portuguesa de Microscopia Electrónica e Biologia Celular (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/03 - 2028/02	Proton therapy for glioblastoma multiforme: preclinical radiobiological studies and evaluation of gold nanoparticles as radiosensitizers Co-supervisor of Ana Rita Teixeira	Biomedical Engineering (PhD) Universidade de Coimbra, Portugal
2024/02 - 2028/01	Exploring Advanced 3D Models of Breast and Lung Cancer for Evaluation of Proton and FLASH Radiotherapy Supervisor of Diogo Engrácia	Biomedical Engineering (PhD) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2023/11 - 2027/10	Radiation and targeted therapy combined approach in metastatic breast and prostate cancers – computational and biological evaluation Co-supervisor of Cátia Rosa	Biomedical Engineering (PhD) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/02 - 2025/02	Biological evaluation of copper-64 chloride as a promising tool for cancer theranostics Supervisor of Catarina Pinto	Biomedical Engineering (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02 - 2025/02	Modeling radiobiological effects of nanoparticles in proton therapy of glioblastomas Co-supervisor of Joana Antunes	Biomedical and Biophysics Engineering (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/02 - 2024/11	Targeting of cationic amino acid transporters with radiometallated amino acids for cancer theranostics Co-supervisor of Ruben Silva	Chemistry (PhD) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2022/03 - 2023/11/06	Antibody Conjugates for Combined Anticancer Radio- and Chemotherapy Co-supervisor of Denise Bravo do Rosário	MSc Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/11/03	Novel antibody fragments - selection and validation as Cystic Fibrosis imaging tools Supervisor of Lucija Marinkovic	Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/06	Preclinical Evaluation of Novel Antitumor Therapies in 3D Cell Models of Breast Cancer Supervisor of Diogo Engrácia	Bioengineering: Regenerative and Precision Medicine (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - 2022/09	Master Fellowship in "Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer” project Co-supervisor of Miguel Tarita	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/04 - 2021/12	Postdoctoral Fellow recruited by the grant "A Molecular Imaging Approach to Cystic Fibrosis" Supervisor of Joana Guerreiro	Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/04	Master Fellowship in UTAustin TOF-PET project Supervisor of Catarina Isabel Pinto	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2016/02 - 2020/10/08	New Molecular Imaging tools for Cystic Fibrosis Supervisor of Vera Filipa Ferreira	Biotechnology and Biosciences (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02 - 2019/10	Development of 3D spheroid cultures of cancer cells for the preclinical evaluation of a novel theranostic agents Supervisor of Catarina Isabel Pinto	Biomedical Engeneering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/01 - 2018/10	Cystic Fibrosis: novel molecular imaging tools Supervisor of Mariana Anderson Morais David	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09 - 2015	Research Fellow Vera Ferreira, MSc in the framework of the projects EXPL/BIM-MEC/0115/2012 (Set2013-Set2014) and ProQr Therapeutics (Aug –Dec 2015) Supervisor	Centro de Ciências e Tecnologias Nucleares, Portugal
2013/09 - 2013/12	Medicina Nuclear Convencional e o seu contributo diagnóstico no Carcinoma da Próstata localizado e metastizado Supervisor of Inês Matreno	Monography - Nuclear Medicine (Other) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/11 - 2013/09	Biological Evaluation of cationic 99mTc(I) complexes as probes for tumoral detection and functional monitoring of multidrug resistance Supervisor of Fernando Toscano	Biomedical Inorganic Chemistry - applications in diagnostic and therapy (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2013/07	A Molecular Imaging approach to Cystic Fibrosis Supervisor of Vera Filipa Ferreira	Biochemistry (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2012/12	99mTc(I) tricarbonyl complexes for mitochondria targeting Supervisor of Ana Bárbara Pereira	Undergraduate research project in Nuclear Medicine (Scientific initiation) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/01 - 2012/07	In vitro evaluation of 99mTc(I) complexes as probes for tumoral detection: influence of the plasma membrane and mitochondrial membrane potential on the cell uptake Supervisor of Teresa Pinto	Undergraduate research project - Nuclear Medicine (Scientific initiation) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/09 - 2011/12	Utilização de radiofármacos de 99mTc para monitorização funcional de resistência a múltiplos fármacos Supervisor of Teresa Pinto	Undergraduate research project - Nuclear Medicine (Scientific initiation) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/09 - 2007/07	Intracellular trafficking of CFTR in polarized cells Co-supervisor of Simão Filipe Luz	Biochemistry (Degree) Universidade de Lisboa Faculdade de Ciências, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2021/07 - Current	Chair of the Organizing Committee of the Workshop 2021 Thematic Strand Radiopharmaceutical Sciences and Health Physics (2021) Workshop (President of the Organising Committee)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021 - Current	Member of the Organizing Committee “First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies), online, September 2021 (2021) Workshop (Member of the Organising Committee)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/11 - 2019/11	Member of the Organizing Committee of the “Workshop 2019 Thematic Strand Radiopharmaceutical Sciences and Health Physics” (2019/11 - 2019/11) Workshop (Member of the Organising Committee)	Centro de Ciências e Tecnologias Nucleares, Portugal
2017/12 - 2017/12	Member of the Organizing Committee of the “1St C2TN workshop- radiation for science and society” (2017/12 - 2017/12) Workshop (Member of the Organising Committee)	Centro de Ciências e Tecnologias Nucleares, Portugal
2015/11 - 2015/11	Member of the Organizing Committee of the ““Imaging and Radiation Biomarkers Workshop” organized by the IST at C2TN, Universidade de Lisboa, November 2015. (2015/11 - 2015/11) Workshop (Member of the Organising Committee)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2004 - 2008	Member of the Organizing Committee of the “European Cystic Fibrosis Society Conference - New Frontiers in the Basic Science of Cystic Fibrosis” – 5 editions in Portugal: 2004 in Tomar, 2005 in Évora, 2006 in Carvoeiro, 2007 in Tavira and 2008 in Régua. (2004 - 2008) Conference (Member of the Organising Committee)	European Cystic Fibrosis Society, Denmark
2007/07 - 2007/07	Member of the Organizing Committee of the “Workshop on Epithelial Biology: Epithelial cells & tissues: production, cultivation and characterization”, organized by the EuroCareCF - (EU) (2007/07 - 2007/07) Workshop (Member of the Organising Committee)	Universidade de Lisboa Faculdade de Ciências, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
1999 - Current	Participation in International and National Scientific Conferences from Cell Biology, Cystic Fibrosis, Medicinal/Bioinorganic Chemistry, Molecular Imaging and Radiopharmaceutical fields - 101 posters in international meetings and 20 in portuguese conferences. Congress
2018/04 - 2018/04	Invited panelist at the “New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications” Organized by IST and IAEA (International atomic energy agency) Round table	New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/07	Development of Novel CXCR4 Directed Ligands for Positron Emission Tomography (PET) and Peptide Receptor Radio Ligand Therapy (PRRT) (Thesis) Main arguer	Leon Stopper (PhD) Technical University of Munich, Germany, Germany
2022/11	Biological impact of magnetic nanoparticles (Thesis) Main arguer	Wilmara Lima (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09	Susceptibilidade dos individuos portadores de mutacoes BRCA1 e BRCA 2 a radiacao de diagnostico (Thesis) Main arguer	Diana Pereira Goncalves (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/11	RA-223 no tratamento do carcinoma da próstata metastático (Thesis) Main arguer	Carolina Alves Silva (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/03/30	Regulation of the TGF-ß1 signaling in cystic fibrosis: the role of LMTK2 (Thesis) Arguer	Daniel Filipe Soares Pereira da Cruz (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/05	Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks (Thesis) Main arguer	Claúdia Almeida Pires Loureiro (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09	Search for new modulators of Phe508del-CFTR retention at the plasma membrane of epithelial cells (Thesis) Main arguer	Ana Margarida Fernandes Pereira de Matos (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10	Characterization of CFTR orphan mutations (Thesis) Main arguer	Sofia Santos Ramalho (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2015/10	Desenvolvimento de um biossensor molecular para o estudo translacional da Fibrose Quística e outras doenças respiratórias (Thesis) Main arguer	Angela Dias Alves (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2015/05	Estudio y dieseño de complejos antitumorales de Pt(II) y Pt(IV), usando nuevas estrategias para conseguir una mayor actividad y especificidade Thesis Member	Medrano MA (PhD) Fundación de la Universidad Autónoma de Madrid, Spain
2012/10	Complexos de Ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos (Thesis) Main arguer	Leonor Corte-Real (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/02	Tc(I)/Re(I) Organometallic for Molecular Imaging of Neoplasic Tissues (Thesis) Arguer	Carolina Moura (PhD) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/12	Recruitment of Pyk2 during complement mediated phagocytosis and expression of kinase domains in insect cell (Thesis) Main arguer	Carina Santos (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2008/06	Characterization of the impact of a novel antimicrobial photosensitizer (Thesis) Main arguer	Sónia Alexandra Gonçalves Mendes (Master) Universidade Católica Portuguesa, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2024/01 - Current	Plos One
2023 - Current	Frontiers Oncology	Frontiers
2023 - Current	Life	MDPI
2023 - Current	Cells	MDPI
2022 - Current	Cancers	MDPI
2022 - Current	Biology	MDPI
2022 - Current	Frontiers in Medicine	Frontiers
2020 - Current	Bioconjugate Chemistry	ACS
2020 - Current	Molecules	MDPI
2019 - Current	JBIC Journal of Biological Inorganic Chemistry (1432-1327)	Springer-Verlag
2019 - Current	Coordination Chemistry Reviews (0010-8545)	Elsevier
2019 - Current	ChemistrySelect	Wiley-VCH Verlag

Association member

	Society Organization name	Role
2021/04/01 - Current	American Society of Chemistry
2013 - Current	Society of Biological Inorganic Chemistry
2010 - Current	European Association of Nuclear Medicine
2004 - Current	Cystic Fibrosis European Network
2001 - Current	American Society of Cell Biology
1999 - Current	Ordem dos Biólogos

Conference scientific committee

	Conference name	Conference host
2015 - 2015	LOWDOSE-PT-2015 - Biological effects and risks of low dose and protracted exposures to ionizing radiation	Instituto Superior Técnico

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2013 - Current	Molecular Biotechnology	Biotecnologia (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2020	Genetic Engeneering	Engenharia Biomédica (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2012	Pharmacogenomics	Ciências Farmacêuticas (Mestrado Intregado) (Mestrado integrado)	Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2007/07 - 2007/07	Workshop on Epithelial Biology: “Epithelial cells & tissues: production, cultivation and characterization”, organized by the EurocareCF Coordination Action	(Outros)	Universidade de Lisboa Faculdade de Ciências, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2017 - Current	Reviewer for the European Science Foundation - expert panel Life and Health Sciences Evaluator	European Science Foundation, France	Fonds Wetenschappelijk Onderzoek Vlaanderen Université de Bordeaux Università degli Studi di Torino AXA SA

Journal scientific committee

	Journal title (ISSN)	Publisher
2023 - Current	Frontiers in Molecular Biosciences - Molecular Diagnostics and Therapeutics - Associate Editor	Frontiers
2022 - Current	Frontiers in Molecular Biosciences - special topic editor	Frontiers
2021 - Current	Molecules - special issue editor	MDPI
2021 - Current	Fontiers in Medicine -Nuclear Medicine - review editor	Frontiers

Distinctions

Award

2006	Medal for Women in Science-Portugal - Medalha L'oreal para as Mulheres na Ciência L'oreal
2005	Gulbenkian Award for Research Incentive - Programa Gulbenkian de Estímulo à Investigação

Other distinction

2022	Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2021	Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2019	Diploma for Excellence in Education (Diploma de Excelência no Ensino) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Diploma for Excellence in Education (Diploma de Excelência no Ensino) Universidade de Lisboa Instituto Superior Técnico, Portugal