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Filipa Fernandes Mendes is a Principal Researcher (with tenure) at Universidade de Lisboa, Instituto Superior Técnico, Department of Nuclear Sciences and Engineering. Her scientific activity is developed at C2TN - Center for Nuclear Sciences and Technologies, where she is currently the Coordinator of the thematic strand "Radiopharmaceutical Sciences and Health Physics" and a member of the Coordinating Commission of the Scientific Council (CC-CC). She was a Visiting Professor at the Technical University of Munich, Germany, in the summer of 2023. Filipa Mendes is focused on merging advances in molecular biology with chemistry (radiopharmaceutical and medicinal) to advance molecular and biomedical imaging and therapy. Given her training and experience in molecular and cellular biology, present research interests are the understanding of the biological mechanisms and molecular interactions of radioactive compounds useful as probes for in vivo molecular imaging and/or targeted radiotherapy. She has extended the evaluation of cancer theranostic compounds (suitable for diagnosis and therapy) to 3D cellular models of cancer, and she was the Editor of a Research Topic on the journal Frontiers in Molecular Biosciences on this subject. Moreover, she is interested in the development of novel molecular tools for the study of ABC transporters involved in human diseases, such as Cystic Fibrosis and Cancer Multidrug Resistance. Since 2023 she is a member of the steering comitee of the European Working Group on Radiobiology of Molecular Radionuclide Therapy. She is the author of 74 articles in peer-reviewed journals (90% in Q1), 24 of which as senior author. She has over 1880 citations (H index 25 and i10 index 52) and was/is the PI of 4 FCT funded projects (including 1 Bilateral with France and 1 FCT-UTAustin) and 1 industry research contract. Filipa Mendes has supervised 8 MSc and 1 PhD to completion and currently supervises/co-supervises 2 MSc and 6 PhD students. Since 2014 she teaches at the Department of Bioengineering, Instituto Superior Técnico, the courses Genetic Engineering and Molecular Biotechnology, and she has received several Excellence in Teaching diplomas.
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Identificação

Identificação pessoal

Nome completo
Filipa Fernandes Mendes

Nomes de citação

  • Mendes, Filipa

Identificadores de autor

Ciência ID
1711-EA6A-041A
ORCID iD
0000-0003-0646-1687
Researcher Id
B-2057-2010
Scopus Author Id
36465350400

Endereços de correio eletrónico

  • fmendes@ctn.tecnico.ulisboa.pt (Profissional)

Moradas

  • C2TN- Centro Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Profissional)
  • DECN- Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa. Estrada Nacional 10, 2695-066 , Bobadela LRS, Loures, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1)
Formação
Grau Classificação
2023/09 - 2023/09
Concluído
 FELASA B - Animal experimentation course - (function A Diretive 2010/63/EU) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/07 - 2020/09/18
Concluído
 Gestão de equipas / Team management (Outros)
Companhia Própria - Formação e Consultoria, Portugal
 na
2008 - 2008
Concluído
 Edição e Revisão de texto / Text Edition and Revision (Diploma de especialização)
Universidade Católica Portuguesa, Portugal
2000 - 2004
Concluído
 Biologia / Biology (Doutoramento)
Especialização em Biologia Celular / Cell Biology
Universidade de Lisboa Faculdade de Ciências, Portugal
"Expression, Localization and Traffic of Wild-Type and Mutant CFTR Protein" (TESE/DISSERTAÇÃO)
 PhD Summa cum laude (Aprovada com distinção e louvor)
1994 - 1999
Concluído
 Biologia - Biologia Microbiana e Genética / Biology - Microbiology and Genetics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Cystic fibrosis: Expression and Intracellular localization of CFTR protein" (TESE/DISSERTAÇÃO)
 18
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/02/01 - Atual Investigador principal (carreira) (Investigação) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/06/11 - 2023/07/29 Investigador principal (carreira) (Investigação) Technical University of Munich, Germany, Alemanha
Technical University of Munich, Germany, Alemanha
2016/01/01 - 2023/01/31 Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
Universidade de Lisboa Departamento de Engenharia e Ciências Nucleares, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/09/01 - 2015/12 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/02/17 - 2014/06/30 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
2008/04/01 - 2012/05/01 Professor Auxiliar Convidado (Docente Universitário) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/04 - Atual Coordinator of the Health Thematic Line, C2TN Research Unit Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/04 - Atual Member of the Coordinating Council, C2TN Research Unit Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/09/01 - 2015/12/31 Principal Investigator – “FCT Investigator” Development Grant (Life and Health Sciences) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2008/09/01 - 2013/08/31 Research Scientist - Ciência 2007 Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2005/01/01 - 2008/07/01 Post-doctoral Fellow Universidade de Lisboa Faculdade de Ciências, Portugal
2000/01/01 - 2004/12/31 PhD Student Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2001/05/01 - 2003/08/31 Visiting Graduate Student University of Virginia Department of Biology, Estados Unidos
1998/09/01 - 1999/07/30 Undergraduate Trainee Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Projetos

Projeto

Designação Financiadores
2023/09 - 2028/11 Improved 177Lu radioconjugates for Prostate Cancer Theranostics - development and evaluation in advanced cellular models
IAEA CRP F-22078
Investigador responsável
International Atomic Energy Agency, Áustria
 International Atomic Energy Agency
Em curso
2024/03 - 2025/04 Personalized 3D Tumor models for Precision RadioTheranostics of Glioblastoma
2022.15449.UTA -FCT UT Austin
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2021/04 - 2025/03 A novel nanoplatform for melanoma targeting with hydroxyquinoline metal complexes
PTDC/QUI-QIN/0586/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2019/01 - 2024/12 Centro de Ciências e Tecnologias Nucleares
154716UID
 Fundação para a Ciência e a Tecnologia
2021/03/01 - 2024/11 Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/0146/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2022/03 - 2024/08 Targeted radiotherapy of radioresistant cancers: a radiobiological study with advanced cell models
2021.09137.CBM
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2021/01 - 2023/12 Organelle-targeted Radiocomplexes for Auger Therapy of Cancer
PTDC/MED-QUI/1554/2020
 Fundação para a Ciência e a Tecnologia
2022/04 - 2023/06 Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer
175166PRJ
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2020/01/01 - 2023/06 In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy
LISBOA-01-0247-FEDER-045904
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/09/01 - 2022/07/31 Targeting the transporters of cationic amino acids for cancer radiotheranostics: experimental and computational chemistry approach
PTDC/QUI-NUC/30147/2017- FCT
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/08/01 - 2022/07/31 Novel Molecular Imaging tools for Cystic Fibrosis
PTDC/BTM-TEC/29256/2017
Investigador responsável
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2015/04 - 2018 Validation of novel tools for detection of CFTR
CF antibodies
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal
 ProQR Therapeutics NV
Concluído
2013/06 - 2016/05 Molecular and Nano Tools for Cancer Theranostics
126789
Provided by PTCRIS: 126789
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2014/04 - 2015/03 Dual Targeting Strategy for EGFR Positive Tumors
134975
Provided by PTCRIS: 134975
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/03 - 2015/02 Preclinical evaluation of ruthenium potential drugs for cancer therapy
info:eu-repo/grantAgreement/FCT/3599-PPCDT/118077/PT
Investigador
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2015 Functional metal complexes that bind to biomolecules
COST Action CM1105
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
Concluído
2012 - 2015 Nitric Oxide Synthase targeting with Re(I)/99mTc(I)-complexes containing L-Arg derivatives: A structure-activity study
PTDC/QUI-QUI/121752/2010
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03 - 2014/08 Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes
Provided by PTCRIS: 114139
114139
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2013/07 - 2014/06 A Molecular Imaging Approach to Cystic Fibrosis
124308
Provided by PTCRIS: 124308
Investigador responsável
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012 - 2014 Target-specific and Heterobimetallic Platinum Complexes: Synthesis, Characterization and Mechanistic Studies
E-23/12
Investigador
Universidade de Lisboa Faculdade de Ciências, Portugal
Concluído
2010 - 2012 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2010 Metallo-drug design and action
COST Action D39
Investigador
2007 - 2008 A novel insight into CFTR Phosphorylation: implications for its processing, trafficking and function
PTDC/BIA-BCM/67058/2006
Investigador
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2008 Novel post-genomic cell-based screens for drug targeting in membrane protein disorders- TargetScreen2
EU FP6-LSH-2005-037365
Investigador Pós-doutorado
Universidade de Lisboa Faculdade de Ciências, Portugal
 European Commission Sixth Framework Programme
Concluído
2002 - 2004 In search of new molecular targets for the development of novel therapeutic strategies for cystic fibrosis
POCTI/MGI/40878/2001
Outra
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2000 - 2003 Thematic Network around Cystic Fibrosis and Related Diseases
EU FP5-QLK3-1999-00241
 European Commission Sixth Framework Programme
2001/02/01 - 2002 Biogenesis and function of CFTR protein with different mutations: molecular basis for clinical and therapeutic heterogeneity of Cystic Fibrosis?
info:eu-repo/grantAgreement/FCT/POCI/35737/PT
Outra
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
1999 - 1999 Cystic Fibrosis - traffic and cellular function of CFTR
PRAXIS/PSAU/C/SAU/55/96
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas". 2021.
    10.22323/1.380.0040
  2. Di Maria S; Belchior, A.; Pereira, Edgar; Do Quental, L.; Oliveira, MC; Mendes, Filipa; Lavrado, J.; Paulo, António; Vaz, P.. "Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies". 2017.
    Publicado • 10.1016/j.radphyschem.2017.01.028
  3. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Perfusion and specific radioprobes for cardiac imaging". Trabalho apresentado em CARDIOTECHNIX 2013 - International Congress on Cardiovascular Technologies, Vilamoura, 2013.
    Publicado
Artigo em revista
  1. Alexandra Martins; Brigida C. Ferreira; Maria Manuela Gaspar; Sandra Vieira; Joana Lopes; Ana S. Viana; António Paulo; et al. "Enhanced Cytotoxicity against a Pancreatic Cancer Cell Line Combining Radiation and Gold Nanoparticles". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16070900.
    10.3390/pharmaceutics16070900
  2. Catarina I. G. Pinto; André D. M. Branco; Bucar, Sara; Alexandra Fonseca; Abrunhosa, Antero J.; Lobato da Silva, Claúdia ; Guerreiro, JF; Mendes, Filipa. Autor correspondente: Mendes, Filipa. "Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids". European Journal of Nuclear Medicine and Molecular Imaging Research na na (2024): na-na.
    Acesso aberto • Aceite para publicação
  3. Antunes, Joana; Pinto, Catarina Isabel; Campello, Maria Paula; Santos, Pedro; Mendes, Filipa; Paulo, António; Sampaio, Jorge Miguel. "Utility of realistic microscopy-based cell models in simulation studies of nanoparticle-enhanced photon radiotherapy". Biomedical Physics & Engineering Express (2024): http://dx.doi.org/10.1088/2057-1976/ad2020.
    10.1088/2057-1976/ad2020
  4. Joana F. Santos; Maria T. Braz; Paula Raposinho; Frederik Cleeren; Irwin Cassells; Simon Leekens; Christopher Cawthorne; et al. "Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier". Molecular Pharmaceutics (2024): https://doi.org/10.1021/acs.molpharmaceut.3c00787.
    10.1021/acs.molpharmaceut.3c00787
  5. João Franco Machado; Marco Sá; Inês Pires; Miguel Tarita da Silva; Fernanda Marques; Jaime A. S. Coelho; Filipa Mendes; et al. "Dual FGFR-targeting and pH-activatable ruthenium–peptide conjugates for targeted therapy of breast cancer". Dalton Transactions (2024): https://doi.org/10.1039/D4DT00497C.
    10.1039/D4DT00497C
  6. Barracosa, Bruno; Felício, João; Carvalho, Ana; Moreira, Leonilde M.; Mendes, Filipa; Verde, Sandra Cabo; Pinto-Varela, Tânia. "Decision support tool to define the optimal pool testing strategy for SARS-CoV-2". Decision Support Systems 175 (2023): 114046. http://dx.doi.org/10.1016/j.dss.2023.114046.
    10.1016/j.dss.2023.114046
  7. Diogo M. Engrácia; Catarina I. G. Pinto; Filipa Mendes. "Cancer 3D Models for Metallodrug Preclinical Testing". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511915.
    10.3390/ijms241511915
  8. Leonor Côrte-Real; Vivien Pósa; Matilde Martins; Raquel Colucas; Nóra V. May; Xavier Fontrodona; Isabel Romero; et al. "Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential". Inorganic Chemistry (2023): https://doi.org/10.1021/acs.inorgchem.3c01066.
    10.1021/acs.inorgchem.3c01066
  9. Leitao, Renan C.F.; Silva, Francisco; Ribeiro, Gabriel H.; Santos, Isabel C.; Guerreiro, Joana F.; Mendes, Filipa; Batista, Alzir A.; et al. "Gallium and indium complexes with isoniazid-derived ligands: Interaction with biomolecules and biological activity against cancer cells and Mycobacterium tuberculosis". Journal of Inorganic Biochemistry 240 (2023): 112091. http://dx.doi.org/10.1016/j.jinorgbio.2022.112091.
    10.1016/j.jinorgbio.2022.112091
  10. Carina Marques Coelho; Lia Pereira; Pamela Teubig; Pedro Santos; Filipa Mendes; Sílvia Viñals; Daniel Galaviz; Federico Herrera. "Radiation as a Tool against Neurodegeneration—A Potential Treatment for Amyloidosis in the Central Nervous System". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232012265.
    10.3390/ijms232012265
  11. Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Côrte-Real, Leonor; Mendes, Filipa; Pessoa, João Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics 623 (2022): 121925. http://dx.doi.org/10.1016/j.ijpharm.2022.121925.
    10.1016/j.ijpharm.2022.121925
  12. Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences 23 13 (2022): 7238-7238. https://doi.org/10.3390/ijms23137238.
    10.3390/ijms23137238
  13. Ana B. Buades; Laura C. J. Pereira; Bruno J. C. Vieira; Ana C. Cerdeira; João C. Waerenborgh; Teresa Pinheiro; António P. A. Matos; et al. "The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]-): a glance into the potential of a low-dose approach for glioblastoma radiotherapy". Inorganic Chemistry Frontiers (2022): https://doi.org/10.1039/D1QI01513C.
    10.1039/D1QI01513C
  14. Nuez-Martínez, Miquel; Queralt-Martín, María; Muñoz-Juan, Amanda; Aguilella, Vicente M.; Laromaine, Anna; Teixidor, Francesc; Viñas, Clara; et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma". Journal of Materials Chemistry B 10 47 (2022): 9794-9815. http://dx.doi.org/10.1039/d2tb01818g.
    10.1039/d2tb01818g
  15. Miquel Nuez-Martinez; Catarina I. G. Pinto; Joana F. Guerreiro; Filipa Mendes; Fernanda Marques; Amanda Muñoz-Juan; Jewel Ann Maria Xavier; et al. "Cobaltabis(dicarbollide) ([o-COSAN]-) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma". Cancers (2021): https://doi.org/10.3390/cancers13246367.
    10.3390/cancers13246367
  16. Palma, Elisa; Raposinho, Paula; Cabral Campello, Maria Paula; Belo, Dulce; Guerreiro, Joana; Alves, Vitor; Fonseca, Alexandra; et al. "Anticancer Activity and Mode of Action of Copper (II)- Bisthiosemicarbazonato Complexes with Pendant Nitrogen Heterocycles". European Journal of Inorganic Chemistry (2021): http://dx.doi.org/10.1002/ejic.202100168.
    Aceite para publicação • 10.1002/ejic.202100168
  17. Vera F. C. Ferreira; Bruno L. Oliveira; Alice D’Onofrio; Carlos M. Farinha; Lurdes Gano; António Paulo; Gonçalo J. L. Bernardes; Filipa Mendes. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00551.
    10.1021/acs.bioconjchem.0c00551
  18. Ben Woods; Rúben D. M. Silva; Claudia Schmidt; Darren Wragg; Marco Cavaco; Vera Neves; Vera F. C. Ferreira; et al. "Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo". Bioconjugate Chemistry (2021): https://doi.org/10.1021/acs.bioconjchem.0c00659.
    10.1021/acs.bioconjchem.0c00659
  19. D'Onofrio, A.; Gano, L.; Melo, R.; Mendes, F.; Oliveira, M.C.; Denoël, T.; Schaefer, N.; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 158 (2021): 233-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099854769&partnerID=MN8TOARS.
    10.1016/j.ejpb.2020.11.015
  20. Ferreira, VFC; Correia, JDG; Farinha, CMF; Mendes, Filipa. "Improved Fmoc-solid-phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology". Journal of Peptide Science (2020):
    Aceite para publicação • PSC-20-0035
  21. Tabacaru, A.; Dediu, A.V.B.; Dinica, R.M.; Carac, G.; Basliu, V.; Campello, M.P.C.; Silva, FFA; et al. "Biological properties of a new mixed lanthanide(III) complex incorporating a dypiridinium ylide". Inorganica Chimica Acta 506 (2020): http://dx.doi.org/10.1016/j.ica.2020.119517.
    No prelo • 10.1016/j.ica.2020.119517
  22. Mendes, Filipa; Gano, Lurdes; Grilo, J; Cunha, S; Fernandes, C.; Paulo, A.. "Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance". Cancer Drug Resistance (2020): http://dx.doi.org/10.20517/cdr.2019.86.
    Acesso aberto • Publicado • 10.20517/cdr.2019.86
  23. Guerreiro, J.F.; Gomes, M.A.G.B.; Pagliari, F.; Jansen, J.; Marafioti, M.G.; Nistico, C.; Hanley, R.; et al. "Iron and copper complexes with antioxidant activity as inhibitors of the metastatic potential of glioma cells". RSC Advances 10 22 (2020): 12699-12710. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083395557&partnerID=MN8TOARS.
    10.1039/d0ra00166j
  24. Pinto, C.I.G.; Bucar, S.; Alves, V.; Fonseca, A.; Abrunhosa, A.J.; da Silva, C.L.; Guerreiro, J.F.; Mendes, F.. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer". Frontiers in Molecular Biosciences 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85097663129&partnerID=MN8TOARS.
    10.3389/fmolb.2020.609172
  25. Alvarez-Valdes, A.; Matesanz, A.I.; Perles, J.; Fernandes, C.; Correia, J.D.G.; Mendes, F.; Quiroga, A.G.. "Novel structures of platinum complexes bearing N-bisphosphonates and study of their biological properties". Journal of Inorganic Biochemistry 191 (2019): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057163055&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2018.11.010
  26. Joana Guerreiro; Vítor Alves; Antero Abrunhosa; António Paulo; Octávia Gil; Filipa Mendes. "Radiobiological Characterization of 64CuCl2 as a Simple Tool for Prostate Cancer Theranostics". Molecules (2018): https://doi.org/10.3390/molecules23112944.
    10.3390/molecules23112944
  27. Vera F. C. Ferreira; Bruno L. Oliveira; João D. Santos; João D. G. Correia; Carlos M. Farinha; Filipa Mendes. "Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe". ChemMedChem 13 14 (2018): 1469-1478. https://doi.org/10.1002/cmdc.201800187.
    10.1002/cmdc.201800187
  28. Palma, E.; Botelho, H.M.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies". Journal of Biological Inorganic Chemistry (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057336330&partnerID=MN8TOARS.
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  29. Francisco Navas; Filipa Mendes; Isabel Santos; Carmen Navarro-Ranninger; Silvia Cabrera; Adoración G. Quiroga. "Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands". Inorganic Chemistry 56 11 (2017): 6175-6183. https://doi.org/10.1021/acs.inorgchem.7b00136.
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  30. Maria Angeles Medrano; Maurício Morais; Vera F. C. Ferreira; João D. G. Correia; António Paulo; Isabel Santos; Carmen Navarro-Ranninger; et al. "Nonconventional trans -Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies". European Journal of Inorganic Chemistry 2017 12 (2017): 1835-1840. https://doi.org/10.1002%2Fejic.201700072.
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  31. Palma, E.; Mendes, F.; Morais, G.R.; Rodrigues, I.; Santos, I.C.; Campello, M.P.C.; Raposinho, P.; et al. "Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes". Journal of Inorganic Biochemistry 167 (2017): 68-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006054906&partnerID=MN8TOARS.
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  32. Scalese, G.; Correia, I.; Benítez, J.; Rostán, S.; Marques, F.; Mendes, F.; Matos, A.P.; Costa Pessoa, J.; Gambino, D.. "Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands". Journal of Inorganic Biochemistry 166 (2017): 162-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995555569&partnerID=MN8TOARS.
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  34. Quental, L.; Raposinho, P.; Mendes, F.; Santos, I.; Navarro-Ranninger, C.; Alvarez-Valdes, A.; Huang, H.; et al. "Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(i) (M = Re,99mTc) complexes". Dalton Transactions 46 42 (2017): 14523-14536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024380558&partnerID=MN8TOARS.
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  35. Vultos, F.; Fernandes, C.; Mendes, F.; Marques, F.; Correia, J.D.G.; Santos, I.; Gano, L.. "A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells". ChemMedChem 12 14 (2017): 1103-1107. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021713335&partnerID=MN8TOARS.
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  36. Morais, M.; Ferreira, V.F.C.; Figueira, F.; Mendes, F.; Raposinho, P.; Santos, I.; Oliveira, B.L.; et al. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters". Dalton Transactions 46 42 (2017): 14537-14547. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032622926&partnerID=MN8TOARS.
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  58. Can, D.; Spingler, B.; Schmutz, P.; Mendes, F.; Raposinho, P.; Fernandes, C.; Carta, F.; et al. "(M=Re or 99mTc) arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX". Angewandte Chemie - International Edition 51 14 (2012): 3354-3357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859226949&partnerID=MN8TOARS.
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  59. Gama, S.; Santos, I.; Mendes, F.; Marques, F.; Santos, I.C.; Carvalho, M.F.; Correia, I.; Pessoa, J.C.; Paulo, A.. "Copper(II) complexes with tridentate pyrazole-based ligands: Synthesis, characterization, DNA cleavage activity and cytotoxicity". Journal of Inorganic Biochemistry 105 5 (2011): 637-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066808&partnerID=MN8TOARS.
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  60. Mendes, F.; Groessl, M.; Nazarov, A.A.; Tsybin, Y.O.; Sava, G.; Santos, I.; Dyson, P.J.; Casini, A.. "Metal-based inhibition of poly(ADP-ribose) polymerase-the guardian angel of DNA". Journal of Medicinal Chemistry 54 7 (2011): 2196-2206. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953796119&partnerID=MN8TOARS.
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Capítulo de livro
  1. Catarina Pinto; Joana Guerreiro; Silva, Francisco; Mendes, Filipa; António Rocha Paulo. "Radiopharmaceuticals for molecular imaging and theranostics of gliobastoma". In New Insights Into Gliobastoma: Diagnosis, Therapeutics and Theranostics, 667-705. Academic Press, 2023.
    Publicado
  2. Matos, M; Mendes, Filipa; Valente, A.; Morais, T.S.; Zinck, P; Garcia, MH; Bicho, M.; Marques, F. "Ruthenium-based anticancer compounds: insights into their cellular targeting and mechanism of action". In Ruthenium Complexes - Photochemical and Biomedical Applications, editado por Alvin A. Holder; Jimmie L. Bullock; Welsey R. Browne; Mark A. LAwrence; Lothar Lilge. Wiley-VCH Verlag, 2017.
Resumo em conferência
  1. Fernandes, Célia; Santos, Joana F.; M. T. Braz; F. Silva; PD Raposinho; J. F. Guerreiro; F. Cleeren; et al. "Mitochondrion-Tropic Radioconjugates Carrying TPP and PSMA Derivatives: Radiobiological and Imaging Studies in Prostate Cancer Models". Trabalho apresentado em World Molecular Imaging Congress 2022, Miami, 2022.
    Publicado
  2. Célia Fernandes; Santos JF; Braz MT; Silva, Francisco; PD Raposinho; Guerreiro JF; Cleeren, Frederik; et al. "Mitochondria-targeted Radiocomplexes for Cancer Theranostics". Trabalho apresentado em TERACHEM - The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, Bressanone, 2022.
    Publicado
  3. Ferreira, VFC; Guerreiro JF; Correia JG; Gonçalves J; Farinha CM; Mendes F. Autor correspondente: Mendes F. "Development of molecular imaging tools to monitor drug efficacy through assessment of CFTR localization in vivo". Trabalho apresentado em North American Cystic Fibrosis Conference, 2021.
    Publicado
  4. Gano, Maria Lurdes; Vultos, F.; Fernandes, Célia; Mendes, Filipa; Correia, JDG. "Biological evaluation of radiolabelled peptides for oestrogen positive tumour theranostics". Trabalho apresentado em Annual Congress of the European Association of Nuclear Medicine October, Barcelona, 2019.
    Publicado
  5. Vultos, F.; Célia Fernandes; Mendes, Filipa; Correia, JDG; Gano, Maria Lurdes. "Indium (III) Complex with a bifunctional agent for dual targeting of cancer cells". Trabalho apresentado em Terachem 2018 – 3rd International symposium on Technetium and Other Radiometals in Chemistry and Medicine, bressanone, 2019.
    Publicado
  6. Vultos, F.; Belo M; Scheepstra M; Francisco Silva; Fernandes, Célia; C. Oliveira; Mendes, Filipa; et al. "Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics". Trabalho apresentado em ESRR’18 – 19th European Symposium on Radiopharmacy and Radiopharmaceuticals,, Groningen, 2018.
    Publicado
  7. Pereira, EL ; Paulo, António; C. Oliveira; Mendes, Filipa; PD Raposinho; Belchior A ; Correia, Isabel M. ; Lavrado J. Autor correspondente: Pereira, EL. "Radioiodinated compounds for Auger therapy". Trabalho apresentado em 29th¿Annual EANM Congress - EANM’16, barcelona, 2016.
    Publicado
  8. Mendes, Filipa; Oliveira, Bruno L.; Morais, Mauricio; Raposinho, P.D.; Correia, JDG. "Radiometallated L-arginine derivatives for imaging nitric oxide synthase in vivo". Trabalho apresentado em 33rd European Peptide Symposium, Sofia, 2014.
    Publicado
  9. Ferreira, VFC; Oliveira, BL; Correia, JDG; Santos, I.; Farinha, CMF; Mendes, Filipa. "Cystic Fibrosis: new molecular imaging tools". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Publicado
  10. Paulo, A.; Rodrigues, I.; Campello, M.P.C.; Morais, G.; Ferreira, VFC; Mendes, Filipa; Santos, I.; Gama, S.. "DNA Binding and Cytotoxic Activity of Zn(II) and Cu(II) Complexes with New Bis(thiosemicarbazone) Derivatives". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Publicado
  11. Rodrigues, I.; Mendes, Filipa; Palma, E.; Correia, I.; Carvalho, MF; Cordeiro Dos Santos, I.; Marques, F.; et al. "New Mixed-Ligand Cu(II) Complexes Acting as “Self-activating” Chemical Nucleases". Trabalho apresentado em 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Publicado
  12. Neto, C.; Oliveira, MC; Fernandes, C.; Gano, Lurdes; Mendes, Filipa; Kniess, T.; Santos, I.. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Trabalho apresentado em 19th International Symposium on Radiopharmaceutical Sciences, 2011.
    Publicado
  13. Mendes, Filipa; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". Trabalho apresentado em Annual Congress of the EANM, Vienna, 2010.
    Publicado
  14. Gano, Lurdes; Mendes, Filipa; Fernandes, C.; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Trabalho apresentado em 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010.
    Publicado
  15. Li, H.; Yang, W.; Mendes, Filipa; Amaral, MD; Sheppard, DN. "Renal cyst formation as tool for CFTR research". Trabalho apresentado em 31st European Cystic Fibrosis Conference, 2008.
    Publicado • 10.2118/4789-ms
  16. Dahimène S; Luz, S.; Mendes, Filipa; Almaça, J.; Barro-Soria, R.; Kunzelmann, K.; Amaral, MD. "Novel cellular models to identify rescuing of F508del-CFTR trafficking defect". Trabalho apresentado em 22nd Annual North American Cystic Fibrosis Conference, 2008.
    Publicado
  17. Mendes, Filipa; Vieira, I.; Alves, PC; Farinha, CMF; Amaral, MD. "Role of Bag-1 on the turnover and processing of wild-type and F508del-CFTR". Trabalho apresentado em 20th Annual North American Cystic Fibrosis Conference, Denver, 2006.
    Publicado
  18. Farinha, CMF; Mendes, Filipa; Roxo-Rosa, M.; Amaral, MD. "Low Temperature Studies Suggest Conformational Differences Between Wild-Type and F508del-CFTR". Trabalho apresentado em 20th Annual North American Cystic Fibrosis Conference, Denver, 2006.
    Publicado
  19. Ramalho, AS; Farinha, CMF; Mendes, Filipa; Neto, M.; Amaral, MD. "Lack of N-terminus causes major impairment on CFTR processing but does not abolish function". Trabalho apresentado em 19th Annual North American Cystic Fibrosis Conference, Baltimore, 2005.
    Publicado
  20. Mendes, Filipa; Wakefield, J.; Amaral, MD; Bebok, Z.; Penque, D.. "Characterization of a New Polarized Epithelial Cell Model to Study CFTR". Trabalho apresentado em 18th Annual North American Cystic Fibrosis Conference, Saint Louis, 2004.
    Publicado
  21. Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Effect of R555K or G550E traffic restoring substitutions upon A561E-CFTR processing". Trabalho apresentado em 25th Congress ECFS, 2002.
    Publicado
  22. Roxo-Rosa, M.; Mendes, Filipa; Farinha, CMF; Beck, S.; Amaral, MD; Penque, D.. "The Misprocessing of A561E-CFTR is partially corrected by R555K or G550E traffic Restoring Substitutions". Trabalho apresentado em 15th Annual North American Cystic Fibrosis Conference, Orlando, 2001.
    Publicado
  23. Mendes, Filipa; Penque, D.; Barroso, M.. "A Polarized Epithelial Cell Model to Study the Membrane Traffic of the Cystic Fibrosis Transmembrane Conductance Regulator". Trabalho apresentado em 2001 Annual ASCB Meeting, Washington, 2001.
    Publicado

Propriedade Intelectual

Patente
  1. Garcia, MH; Morais, T.S.; Tomaz AI; Marques F; Mendes, Filipa. 2013. "Transition metal complexes for pharmaceutical applications".
    Concedida/Emitida
  2. Amaral, MD; Dahimène S; Mendes, Filipa. 2011. "Two novel human epithelial cell lines to be used in assays for traffic studies/ screens of CFTR protein (wild-type and with the F508del mutation". Portugal.
    Pendente
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/09 Evaluation of the therapeutic potential of 64CuCl2 in 3D models of glioblastoma 10th international symposium on physical, molecular, cellular, and medical aspects of Auger electron processes
(Montpellier, França)
2023/07 Biological evaluation of 64CuCl2 as a promising tool for cancer theranostics Invited talk
Department of Pharmaceutical and Pharmacological Sciences, KU Leuven (Leuven, Bélgica)
2023/06 Radiopharmaceutical Sciences Research at C2TN Invited talk at the Chair of Radiopharmaceutical Chemistry
Technical University of Munich (Munich , Alemanha)
2023/03 Radiopharmaceuticals and Theranostics - basic concepts and (pre)clinical examples Workshop “ New Approaches in Cancer (Radio)theranostics"
Department of Life Sciences, University of Coimbra (Coimbra , Portugal)
2023/03 No Longer Flat: 3D Models of Cancer for Evaluation of Metallodrugs Symposium “Metals...and Beyond: the next 50 years"
Technical University of Munich (Raitenhaslach, Alemanha)
2022/11 Preclinical Evaluation of Radiopharmaceuticals PRISMAP young scientists’ event
PRISMAP project (EU Horizon 2020) (Padova, Itália)
2022/07 Nano-particle research at C2TN - Update on the Biological Studies within TPPT Nanoparticle Research Workshop
Proton Therapy Center, MD Anderson Cancer Center, University of Texas, Houston (Houston, Estados Unidos)
2022/07 TOF-PET FOR PROTON THERAPY (TPPT)- an update of the biological studies Invited talk Department of Physics
Department of Physics, University Texas Austin (Austin, Estados Unidos)
2021/10 Innovative agents for Nuclear Imaging and/or Systemic Radiotherapy of cancer Webinar - A Universidade de Lisboa à Procura de Respostas para o Cancro
Oncology working group, Rede Saúde da Universidade de Lisboa (Lisboa, Portugal)
2021/09 Health and Environment Research Areas at C2TN First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies)
2019/09/12 Assessment of CFTR localization in vivo to monitor efficacy of CFTR correctors Invited Talk - REAP Expert Meeeting
European Cystic Fibrosis Society (ECFS) (Lisboa, Portugal)
2019/09 New insights on the radiobiological effects of 64CuCl2 - a simple tool for prostate cancer theranostics I NOVA Biophysica Internacional Conference
(Lisboa, Portugal)
2019/03 Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe 16th European Cystic Fibrosis Basic Science Conference
European Cystic Fibrosis Society (Dubrovnik, Croácia)
2018/06 Molecular and Cell Biology methods for validation of (imaging) biomarkers Summer School “Development and Pre-clinical Evaluation of Radiopharmaceuticals”
Marie Curie Innovative Training Network "MEDICIS-Promed" (Cascais, Portugal)
2017/11 Ionizing radiation and health: Imaging and exposure biomarkers Physics Department seminars
Physics Departmentm, IST (Lisboa, Portugal)
2014/08 Molecular Imaging probes for in vivo detection of the Cystic Fibrosis Protein 2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules
COST Action CM1105 (Zurich, Suiça)
2014/05 Biological relevance and general applications of peptides Training School “Peptides for Targeted Drug Delivery"
COST Action CM1105“Functional metal complexes that bind to biomolecules” (Bobadela LRS, Portugal)
2014/04 Biomarkers for the Theranostic Strategy - Cancer and Molecular Theranostics Expert meeting
COST action CM1105 (Bobadela LRS, Portugal)
2013/10 New Platinum (II) complexes with DNA-targeting ability 1st Meeting on Functional metal complexes that bind to biomolecules
COST ACTION CM1105 (Barcelona, Espanha)
2013/09 Perfusion and specific radioprobes for cardiac imaging Cardiotecnhix International Congress on Cardiovascular Technologies
Cardiotecnhix (Vilamoura, Portugal)
2012/12 Imaging in the era of molecular oncology: new probes for detection of multidrug resistance Bioengineering Department Seminars
IST (Lisboa, Portugal)
2012/12 Sondas para Imagiologia Cardiovascular Workshop “Biomarcadores sanguíneos e imagiologia da placa aterosclerótica”
Instituto Superior Técnico (Sacavém, Portugal)
2012/10 From cardiology to oncology: new radioactive probes for detection of cancer multidrug resistance Chem Forum -Autumn Edition
IST (Lisboa, Portugal)
2008/12 Pharmacogenomics – contribute for cancer therapeutics Symposium Cancer and Therapeutic Approaches
Universidade Lusófona de Humanidades e Tecnologias (Lisboa, Portugal)
2007 An approach to chaperone therapy: correcting the basic defect in Cystic Fibrosis V International Symposium Sociedade Portuguesa de Doenças Metabólicas
Sociedade Portuguesa de Doenças Metabólicas (Porto, Portugal)
2007 Role of Bag-1 in turnover and processing of wild-type and F508del-CFTR Workshop Proteins in Health and Disease: from structure to function
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2006 Modulation of CFTR biosynthesis and maturation by molecular chaperones: implications for Cystic Fibrosis Dia do Jovem Investigador do Instituto Ricardo Jorge
Instituto Ricardo Jorge (Lisboa, Portugal)
2004 Characterization of a New Polarized Epithelial Cell Model to Study the Cystic Fibrosis Transmembrane Conductance Regulator New Frontiers in the Basic Science of Cystic Fibrosis
European Cystic Fibrosis Society (Tomar, Portugal)
1999 Imunolocalização da proteína F508del-CFTR na região apical de células epiteliais nasais XXXIV Reun Ann Soc Port Mic Electr e Biol Cel
Sociedade Portuguesa de Microscopia Electrónica e Biologia Celular (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/03 - 2028/02 Proton therapy for glioblastoma multiforme: preclinical radiobiological studies and evaluation of gold nanoparticles as radiosensitizers
Coorientador de Ana Rita Teixeira
Biomedical Engineering (Doutoramento)
Universidade de Coimbra, Portugal
2024/02 - 2028/01 Exploring Advanced 3D Models of Breast and Lung Cancer for Evaluation of Proton and FLASH Radiotherapy
Orientador de Diogo Engrácia
 Biomedical Engineering (Doutoramento)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2023/11 - 2027/10 Radiation and targeted therapy combined approach in metastatic breast and prostate cancers – computational and biological evaluation
Coorientador de Cátia Rosa
Biomedical Engineering (Doutoramento)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021/02 - 2025/02 Biological evaluation of copper-64 chloride as a promising tool for cancer theranostics
Orientador de Catarina Pinto
 Biomedical Engineering (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/02 - 2025/02 Modeling radiobiological effects of nanoparticles in proton therapy of glioblastomas
Coorientador de Joana Antunes
 Biomedical and Biophysics Engineering (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/02 - 2024/11 Targeting of cationic amino acid transporters with radiometallated amino acids for cancer theranostics
Coorientador de Ruben Silva
 Chemistry (Doutoramento)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2022/03 - 2023/11/06 Antibody Conjugates for Combined Anticancer Radio- and Chemotherapy
Coorientador de Denise Bravo do Rosário
 MSc Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/11/03 Novel antibody fragments - selection and validation as Cystic Fibrosis imaging tools
Orientador de Lucija Marinkovic
 Microbiology (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/09 - 2023/06 Preclinical Evaluation of Novel Antitumor Therapies in 3D Cell Models of Breast Cancer
Orientador de Diogo Engrácia
 Bioengineering: Regenerative and Precision Medicine (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - 2022/09 Master Fellowship in "Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer” project
Coorientador de Miguel Tarita
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/04 - 2021/12 Postdoctoral Fellow recruited by the grant "A Molecular Imaging Approach to Cystic Fibrosis"
Orientador de Joana Guerreiro
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/04 Master Fellowship in UTAustin TOF-PET project
Orientador de Catarina Isabel Pinto
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2016/02 - 2020/10/08 New Molecular Imaging tools for Cystic Fibrosis
Orientador de Vera Filipa Ferreira
 Biotechnology and Biosciences (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02 - 2019/10 Development of 3D spheroid cultures of cancer cells for the preclinical evaluation of a novel theranostic agents
Orientador de Catarina Isabel Pinto
 Biomedical Engeneering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/01 - 2018/10 Cystic Fibrosis: novel molecular imaging tools
Orientador de Mariana Anderson Morais David
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/09 - 2015 Research Fellow Vera Ferreira, MSc in the framework of the projects EXPL/BIM-MEC/0115/2012 (Set2013-Set2014) and ProQr Therapeutics (Aug –Dec 2015)
Orientador
Centro de Ciências e Tecnologias Nucleares, Portugal
2013/09 - 2013/12 Medicina Nuclear Convencional e o seu contributo diagnóstico no Carcinoma da Próstata localizado e metastizado
Orientador de Inês Matreno
 Monography - Nuclear Medicine (Outra)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/11 - 2013/09 Biological Evaluation of cationic 99mTc(I) complexes as probes for tumoral detection and functional monitoring of multidrug resistance
Orientador de Fernando Toscano
 Biomedical Inorganic Chemistry - applications in diagnostic and therapy (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2013/07 A Molecular Imaging approach to Cystic Fibrosis
Orientador de Vera Filipa Ferreira
 Biochemistry (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09 - 2012/12 99mTc(I) tricarbonyl complexes for mitochondria targeting
Orientador de Ana Bárbara Pereira
Undergraduate research project in Nuclear Medicine (Iniciação científica)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012/01 - 2012/07 In vitro evaluation of 99mTc(I) complexes as probes for tumoral detection: influence of the plasma membrane and mitochondrial membrane potential on the cell uptake
Orientador de Teresa Pinto
Undergraduate research project - Nuclear Medicine (Iniciação científica)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/09 - 2011/12 Utilização de radiofármacos de 99mTc para monitorização funcional de resistência a múltiplos fármacos
Orientador de Teresa Pinto
Undergraduate research project - Nuclear Medicine (Iniciação científica)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006/09 - 2007/07 Intracellular trafficking of CFTR in polarized cells
Coorientador de Simão Filipe Luz
 Biochemistry (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/07 - Atual Chair of the Organizing Committee of the Workshop 2021 Thematic Strand Radiopharmaceutical Sciences and Health Physics (2021)
Oficina (workshop) (Presidente da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2021 - Atual Member of the Organizing Committee “First Workshop of LAPMET (Laboratory for Physics of Materials and Emerging Technologies), online, September 2021 (2021)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/11 - 2019/11 Member of the Organizing Committee of the “Workshop 2019 Thematic Strand Radiopharmaceutical Sciences and Health Physics” (2019/11 - 2019/11)
Oficina (workshop) (Membro da Comissão Organizadora)
 Centro de Ciências e Tecnologias Nucleares, Portugal
2017/12 - 2017/12 Member of the Organizing Committee of the “1St C2TN workshop- radiation for science and society” (2017/12 - 2017/12)
Oficina (workshop) (Membro da Comissão Organizadora)
 Centro de Ciências e Tecnologias Nucleares, Portugal
2015/11 - 2015/11 Member of the Organizing Committee of the ““Imaging and Radiation Biomarkers Workshop” organized by the IST at C2TN, Universidade de Lisboa, November 2015. (2015/11 - 2015/11)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2004 - 2008 Member of the Organizing Committee of the “European Cystic Fibrosis Society Conference - New Frontiers in the Basic Science of Cystic Fibrosis” – 5 editions in Portugal: 2004 in Tomar, 2005 in Évora, 2006 in Carvoeiro, 2007 in Tavira and 2008 in Régua. (2004 - 2008)
Conferência (Membro da Comissão Organizadora)
 European Cystic Fibrosis Society, Dinamarca
2007/07 - 2007/07 Member of the Organizing Committee of the “Workshop on Epithelial Biology: Epithelial cells & tissues: production, cultivation and characterization”, organized by the EuroCareCF - (EU) (2007/07 - 2007/07)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Lisboa Faculdade de Ciências, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
1999 - Atual Participation in International and National Scientific Conferences from Cell Biology, Cystic Fibrosis, Medicinal/Bioinorganic Chemistry, Molecular Imaging and Radiopharmaceutical fields - 101 posters in international meetings and 20 in portuguese conferences.
Congresso
2018/04 - 2018/04 Invited panelist at the “New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications” Organized by IST and IAEA (International atomic energy agency)
Mesa-redonda
 New Horizons for Nuclear Sciences and Technologies in Portugal -health and cancer applications
Universidade de Lisboa Instituto Superior Técnico, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/07 Development of Novel CXCR4 Directed Ligands for Positron Emission Tomography (PET) and Peptide Receptor Radio Ligand Therapy (PRRT)
Arguente principal
 Leon Stopper (Doutoramento)
Technical University of Munich, Germany, Alemanha
2022/11 Biological impact of magnetic nanoparticles
Arguente principal
 Wilmara Lima (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09 Susceptibilidade dos individuos portadores de mutacoes BRCA1 e BRCA 2 a radiacao de diagnostico
Arguente principal
 Diana Pereira Goncalves (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/11 RA-223 no tratamento do carcinoma da próstata metastático
Arguente principal
 Carolina Alves Silva (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/03/30 Regulation of the TGF-ß1 signaling in cystic fibrosis: the role of LMTK2
Arguente
 Daniel Filipe Soares Pereira da Cruz (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/05 Regulation of epithelial chloride transport by phospho-tyrosine-initiated protein networks
Arguente principal
 Claúdia Almeida Pires Loureiro (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/09 Search for new modulators of Phe508del-CFTR retention at the plasma membrane of epithelial cells
Arguente principal
 Ana Margarida Fernandes Pereira de Matos (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/10 Characterization of CFTR orphan mutations
Arguente principal
 Sofia Santos Ramalho (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/10 Desenvolvimento de um biossensor molecular para o estudo translacional da Fibrose Quística e outras doenças respiratórias
Arguente principal
 Angela Dias Alves (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/05 Estudio y dieseño de complejos antitumorales de Pt(II) y Pt(IV), usando nuevas estrategias para conseguir una mayor actividad y especificidade
Vogal
 Medrano MA (Doutoramento)
Fundación de la Universidad Autónoma de Madrid, Espanha
2012/10 Complexos de Ruténio como potenciais agentes terapêuticos: estudos dos mecanismos de captação celular e modulação de enzimas metabólicos
Arguente principal
 Leonor Corte-Real (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/02 Tc(I)/Re(I) Organometallic for Molecular Imaging of Neoplasic Tissues
Arguente
 Carolina Moura (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/12 Recruitment of Pyk2 during complement mediated phagocytosis and expression of kinase domains in insect cell
Arguente principal
 Carina Santos (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008/06 Characterization of the impact of a novel antimicrobial photosensitizer
Arguente principal
 Sónia Alexandra Gonçalves Mendes (Mestrado)
Universidade Católica Portuguesa, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2015 - 2015 LOWDOSE-PT-2015 - Biological effects and risks of low dose and protracted exposures to ionizing radiation Instituto Superior Técnico

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023 - Atual Frontiers in Molecular Biosciences - Molecular Diagnostics and Therapeutics - Associate Editor Frontiers
2022 - Atual Frontiers in Molecular Biosciences - special topic editor Frontiers
2021 - Atual Molecules - special issue editor MDPI
2021 - Atual Fontiers in Medicine -Nuclear Medicine - review editor Frontiers

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2017 - Atual Reviewer for the European Science Foundation - expert panel Life and Health Sciences
Avaliador
 European Science Foundation, França Fonds Wetenschappelijk Onderzoek Vlaanderen

Université de Bordeaux

Università degli Studi di Torino

AXA SA

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2013 - Atual Molecular Biotechnology Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2020 Genetic Engeneering Engenharia Biomédica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008 - 2012 Pharmacogenomics Ciências Farmacêuticas (Mestrado Intregado) (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2007/07 - 2007/07 Workshop on Epithelial Biology: “Epithelial cells & tissues: production, cultivation and characterization”, organized by the EurocareCF Coordination Action (Outros) Universidade de Lisboa Faculdade de Ciências, Portugal

Membro de associação

Nome da associação Tipo de participação
2021/04/01 - Atual American Society of Chemistry
2013 - Atual Society of Biological Inorganic Chemistry
2010 - Atual European Association of Nuclear Medicine
2004 - Atual Cystic Fibrosis European Network
2001 - Atual American Society of Cell Biology
1999 - Atual Ordem dos Biólogos

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2024/01 - Atual Plos One
2023 - Atual Frontiers Oncology Frontiers
2023 - Atual Life MDPI
2023 - Atual Cells MDPI
2022 - Atual Cancers MDPI
2022 - Atual Biology MDPI
2022 - Atual Frontiers in Medicine Frontiers
2020 - Atual Bioconjugate Chemistry ACS
2020 - Atual Molecules MDPI
2019 - Atual JBIC Journal of Biological Inorganic Chemistry (1432-1327) Springer-Verlag
2019 - Atual Coordination Chemistry Reviews (0010-8545) Elsevier
2019 - Atual ChemistrySelect Wiley-VCH Verlag
Distinções

Prémio

2006 Medal for Women in Science-Portugal - Medalha L'oreal para as Mulheres na Ciência L'oreal
2005 Gulbenkian Award for Research Incentive - Programa Gulbenkian de Estímulo à Investigação

Outra distinção

2022 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2021 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
2019 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Diploma for Excellence in Education (Diploma de Excelência no Ensino)
Universidade de Lisboa Instituto Superior Técnico, Portugal