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Maria Manuela de Jesus Guilherme Gaspar is a Researcher at the Faculty of Pharmacy, Universidade de Lisboa, member of the Research Institute for Medicines, iMed.ULisboa since January 2009 and, collaborator at Instituto de Biofísica e Engenharia Biomédica (IBEB), Faculty of Sciences, Universidade de Lisboa since december 2023. She completed the graduation in Engenharia Química Industrial in 1991, at Instituto Superior de Engenharia de Lisboa. She obtained her PhD degree in 2005 in Pharmacy, Pharmaceutical Technology, Universidade de Lisboa with the thesis entitled "Liposomal formulations of Rifabutin and Acylated Superoxide Dismutase". Between october 2007 - october 2008 she was a post-doc at School of Pharmacy and Pharmaceutical Sciences, Trinity College, University Dublin, Ireland. In the last decades, the research has been focused on design, development and biological evaluation of drug delivery systems for improving the therapeutic index of incorporated molecules for the treatment of infectious, inflammatory and cancer diseases. Design, characterization and stability evaluation of appropriated delivery systems, of lipid polymeric and metallic nature for drug delivery and targeting using different routes of administration namely pulmonary, intranasal, dermal, parenteral and oral. In vitro and in vivo evaluation of low and high molecular weight molecules such as antibiotics (rifabutin, paramomycin), enzymes (L-Asparaginase, Superoxide Dismutase). In vitro screening, of new synthesized molecules including metal-based complexes with potential antitumor activity, using 2D and 3D models. Establishment of appropriate infectious and cancer murine models, such as M. avium, M. tuberculosis, leishmania, MRSA, melanoma, breast and colon cancer, for evaluating the therapeutic effect of developed nanoformulations. She has participated in more than 30 research projects as team member or as PI. She has been supervising Post-doc, PhD, master and undergraduate students (> 85) . She is co-author of more than 117 articles in journals (Indexed Scopus), book chapters (9) and patents (h-index 34). She is responsible for the animal facilities (since 2009) and member of the welfare organ of the Faculty of Pharmacy since 2011. In addition, she also belongs to governing bodies of the Portuguese Society for Laboratory Animal Science.
Identification

Personal identification

Full name
Maria Manuela de Jesus Guilherme Gaspar
Date of birth
1961/03/24
Gender
Female

Citation names

  • Gaspar, Maria Manuela

Author identifiers

Ciência ID
3A10-0732-13F5
ORCID iD
0000-0001-6814-7226
Researcher Id
AAM-2706-2020
Scopus Author Id
15834627800

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2007 - 2008/10/09
Concluded
Development of Novel Therapeutics for Lung Cancer (Pós-doutoramento)
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Ireland
2005/02/17
Concluded
Pharmacy, Pharmaceutical Technology (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Liposomal Formulations of rifabutin and acylated superoxide Dismutase" (THESIS/DISSERTATION)
Summa cum laude
1991
Concluded
Engenharia Química Industrial (Licenciatura)
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
"not applicable" (THESIS/DISSERTATION)
treze valores
Affiliation

Science

Category
Host institution
Employer
2009/01/01 - Current Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005/02/17 - 2008/12/31 Auxiliary Researcher (Research) Instituto Nacional de Engenharia Tecnologia e Inovação, Portugal
1997/03 - 2005/02/16 Research Assistant (Research) Instituto Nacional de Engenharia Tecnologia e Inovação, Portugal

Positions / Appointments

Category
Host institution
Employer
2007/10/01 - 2008/10/06 Post-doc Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Ireland

Others

Category
Host institution
Employer
1992/05 - 1997/03 Superior Technician Instituto Nacional de Engenharia Tecnologia e Inovação, Portugal
1985/12/20 - 1992/05 Laboratory Technician Laboratório de Energia, Portugal
Laboratório Nacional de Energia e Geologia - Campus do Lumiar, Portugal
Projects

Contract

Designation Funders
2021/04/01 - 2025/03/31 Rifabutin liposomes: a novel nanotechnological strategy for effective treatment of systemic methicilin-resistant staphylococus aureus infections
Phospholipid Research Center
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2021/03/01 - 2025/03/30 Novel nanoplatforms for targeting melanoma with 8-hydroxyquinoline metal complexes, PTDC/QUI-QIN/0586/2020.
PTDC/QUI-QIN/0586/2020
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2025 Ferrous Iron-Activable Drug Conjugates: Targeting Iron Metabolism in the Era of Precision Oncology
2022.07857.PTDC
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2025 Improving the efficacy of cancer treatments while reducing their toxicity
LCF/TR/CI22/52660003
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento
Ongoing
2022/07/01 - 2024/06/01 Analyzing NeuroIMmune dysregulation in Alzheimer´s disease toward a Therapy with miRNA-loaded Exosomes
PTDC/MED-NEU/2382/2021
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/07 - 2024/06 Analyzing NeuroIMmune dysregulation in Alzheimer´s disease toward a Therapy with miRNA-loaded Exosomes
PTDC/MED-NEU/2382/2021
Fundação para a Ciência e a Tecnologia
2020/01/01 - 2023/12/31 Biomorphic platforms for the pulmonary delivery of nanotherapeutics
Proposal PID2019-105739GB-I00, BMC
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2022/03/01 - 2023/06/30 Proof of concept for biological activity of cannabinoids and terpenes - cosmetical applications
Exmceuticals
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2018/10 - 2022/09 Uma nova abordagem na obtenção de fármacos activos contra a tuberculose. Co-fármacos activados por esterases micobacterianas
28080/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2022/09 Manipulation of lysosomal cathepsins and their inhibitors cystatins in human macrophages as a host directed therapeutic strategy for tuberculosis and co-infection with HIV
28182/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2022/09 Phage-Enzybiotic : dealing with critical pathogenic antibiotic-resistant bacteria
28978/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2022/09 Targeting aquaporin-3 as a novel therapeutic approach for skin cancer
28977/2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09 - 2022/08 Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
FEDER/FRN e OE / 30266/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/08 - 2022/07 Novel upconversion nanoparticles for multimodal therapy of melanoma: pHOtothermal Therapy, PhOtodynamic therapy and chemoTherapy
POCI-01-0145-FEDER-031794 /2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10 - 2022/06 Nanoformulated Hybrid Molecules For Specific Targeting Melanoma Metastasis
PTDC/MED-QUI/31721/2017
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/10 - 2022/05 LYMPHOTARGET - Desenvolvimento de imunolipossomas para o tratamento direcionado do Linfoma não-Hodgkin,
PGG/050/2019
Researcher
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Gilead Sciences Lda
Ongoing
2015/01 - 2018/12 Research Institute for Medicines, iMed.ULisboa
UID/DTP/04138/2013
Fundação para a Ciência e a Tecnologia
2013/04 - 2015/12 Fighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/03 - 2015/12 Helicobacter pylori phages: translating an underestimated phenomenon into a therapeutic application
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2014/03 - 2015/09 Priming of Mesenchymal Stromal Cells from the Umbilical Cord Tissue (UCX®) as a Means of Incrementing Their Therapeutic Potency for Rheumatoid Arthritis
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2013/07 - 2014/12 Cutaneous leishmaniasis: an innovative idea to explore the topical treatment of skin lesions
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/12 A new life for old antimycobacterial drugs: development of prodrugs of pyrazinoic acid activated by mycobacterial esterases as a way to circumvent resistance to pyrazinamide
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2013/10 Development of new polymer-liposome complexes combining experimental and computational approaches
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/03 - 2013/08 A challenge for the treatment of parasitic diseases: rational design of Trifluralin derivatives and appropriate nanoformulations
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2009/12 Strategies to improve the therapeutic effect of antimycobacterial drugs
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2002/01 - 2005/12 Therapeutic systems for treatment of mycobacterial infections
POCTI/FCB/36416/99
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2002/01 - 2005/12 Superoxide dismutase enzymosomes for treatment of inflammatory diseases and ischaemia-reperfusion situations
POCTI/FCB/42259/2001
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2001/01 - 2002/12 Microgravity protein crystal growth-determination of protein stucture for rational design of new enzymatic inhibitors
POCTI/BME/36666/99
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1997/01 - 2000/12 Direccionamento de superóxido dismutase e catalase através da modificação química e/ou incorporação em lipossomas, para a terapia de uma doença autoimune, projecto
PRAXIS, Contrato Nº 2/2.1/SAU/1360/95
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1997/01 - 2000/12 Novas formas bioactivas de produtos oftalmológicos e dermatológicos
SINDEPEDIP, 25/00243
Researcher
SINDEPEDIP
Concluded
1997/01 - 1999/12 Projecto para criação de uma unidade de síntese, pesquisa e desenvolvimento de moléculas com actividade farmacológica
SINDESFAR-PM/480/97/058
Researcher
SINDESFAR
Concluded
1993/01 - 1996/12 Hemissíntese de Ansamicinas, Caracterização, Imobilização em Lipossomas e Avaliação Biológica
JNICT, Contrato Nº PBIC/C/SAU/1537/92
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1986/01 - 1989/12 Imobilização em Lipossomas de Enzimas com Acção Terapêutica
JNICT, Contrato Nº 836.86.212
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Amaral, Mariana Neves; Pinho, Jacinta O.; Gaspar, M. Manuela; Reis, Catarina Pinto. "Challenges in delivery of plant actives". In Phytopharmaceuticals and Herbal Drugs, 35-82. Elsevier, 2023.
    Published • 10.1016/b978-0-323-99125-4.00008-1
  2. Pinho, Jacinta Oliveira; Lopes, Joana; Albino, Melissa; Reis, Catarina; Matias, Mariana; Gaspar, Maria Manuela. "Advances in nanotechnology-related strategies against melanoma". In Mitochondrial Dysfunction and Nanotherapeutics, 385-424. Elsevier, 2021.
    Published • 10.1016/b978-0-323-85666-9.00009-7
  3. Mendes, T.; Gaspar, Maria Manuela; Simões, S.; Ascensob, A.. "Lipid vesicles for skin delivery: Evolution from first generation". In Carrier-Mediated Dermal Delivery, 281-322. Taylor & Francis Group, 2017.
    Published • 10.4324/9781315364476-8
  4. Simões, S.; Carvalheiro, M.; Gaspar, Maria Manuela. "Lipid-based nanocarriers for the treatment of infected skin lesions". In Carrier-Mediated Dermal Delivery, 385-430. Taylor & Francis Group, 2017.
    Published • 10.4324/9781315364476-11
  5. Sitterberg, Johannes; Gaspar, Maria Manuela; Ehrhardt, Carsten; Bakowsky, Udo. "Atomic Force Microscopy for the Characterization of Proteoliposomes". In Methods in Molecular Biology, 351-361. Humana Press, 2009.
    Published • 10.1007/978-1-60761-447-0_23
  6. Cruz, Maria Eugénia Meirinhos; Sandra Isabel Dias Simões; Corvo, Maria Luisa ; Martins, Maria Bárbara; Gaspar, Maria Manuela. "Formulation of NPDDS for Macromolecules". 35-49. Informa Healthcare., Taylor & Francis Group, 2009.
  7. Cruz, Maria Eugénia Meirinhos; Maria Bárbara Martins; Corvo, Maria Luísa; Gaspar, Maria Manuela; E. M. M. Oliveira; Maria Antonieta Ferrara. "Enzimas em Medicamentos e Diagnósticos". In Enzimas em Biotecnologia: produção, aplicações e mercado, 307-331. Rio de Janeiro, Brazil: Interciência Ltda, 2008.
    Published
  8. Eugénia, M. Cruz; Manuela Gaspar, M.; Bárbara, M. Martins; Luísa Corvo, M.. "Liposomal Superoxide Dismutases and Their Use in the Treatment of Experimental Arthritis". In Methods in Enzymology, 395-413. Amsterdam: Elsevier, 2005.
    Published • 10.1016/s0076-6879(05)91022-7
Conference abstract
  1. A Martins; Brígida C Ferreira; Gaspar, Maria Manuela; Vieira, Sandra. "Potential of concomitant radiation therapy with gold nanoparticles for pancreatic cancer.". Paper presented in ESTRO2024, Glasgow, 2024.
    Accepted
  2. Penetra, Maria João; Francisco, Ana Paula; O. Pinho, Jacinta; Mendes, Eduarda; Rodrigues, Cecília MP; Amaral, Joana; Gaspar, Maria Manuela. Corresponding author: Penetra, Maria João. "Liposomes as a tool to potentiate the antitumor effect of a new hybrid molecule: in vitro and in vivo studies (Oral presentation)". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  3. Pinho, JO; Matias, Mariana; Francisco, Ana; Eleutério, Carla; Perry, Maria Jesus; Mendes, Eduarda; Amaral, Joana; Rodrigues, Cecília MP; Gaspar, Maria Manuela. "In vitro and in vivo high antimelanoma potential of a novel hybrid molecule following its incorporation in long circulating liposomes (Oral presentation)". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery 2021 (@DD21), Faculty of Pharmacy, University of Lisboa., Lisboa, 2021.
    Published
  4. Lopes, Joana; Albino, Melissa; Matos, C. P.; Correia, Isabel; Reis, Catarina; Gaspar, Maria Manuela. "Liposomes as a tool to potentiate in vitro and in vivo the anti-tumor effect of new coordination compounds (Oral presentation)". Paper presented in 25th Anniversary¿ XIII Spanish-Portuguese Conference on Controlled Drug Release, 2020.
  5. Matias, Mariana; Pinho, JO; Francisco, Ana; Eleutério, Carla; Perry, Maria Jesus; Mendes, Eduarda; Amaral, Joana; Rodrigues, Cecília MP; Gaspar, Maria Manuela. "A novel nanoformulated hybrid molecule as a promising strategy for the treatment of melanoma". Paper presented in Congresso Nacional dos Farmacêuticos 2020 e XIV Congresso Mundial dos Farmacêuticos de Língua Portuguesa, 2020.
    Published
  6. Camões, Sérgio P.; Dias, Catarina T.; Rodrigues, Joana S; Serras, Ana S.; Gaspar, Maria Manuela; Simões, Sandra; Ferreira, R.; et al. "Delivery of exosomes derived from 3D-cultured human neonatal mesenchymal stromal cells improves cutaneous wound healing". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019.
    10.3389/978-2-88945-675-8
  7. Pinho, Jacinta; Ana Paula Francisco; Carla Vânia Eleutério; Eduarda Mendes; Perry, Maria Jesus; Amaral, Joana; Rodrigues, Cecília MP; Gaspar, Maria Manuela. "Nanoformulated hybrid molecules with high in vitro and in vivo potential against melanoma". Paper presented in EUFEPS Annual Meeting 2019, Frankfurt, 2019.
    Published
Conference poster
  1. Neto, Íris; Lopes, Joana; Côrte-Real, Leonor; Correia, Isabel; Rocha, João; Ferreira-Gonçalves, Tânia; Reis, Catarina Pinto; Gaspar, Maria Manuela. "Novel metallodrugs for cancer treatment: Optimizizing their therapeutic efficacy using nanoliposomes". Paper presented in 15th iMed.ULisboa Postgraduate Students Meeting, 2024.
  2. Vueba, Manuel; Neto, Íris; Gaspar, Maria Manuela; João F. Pinto; Catarina Pinto Reis. Corresponding author: Catarina Pinto Reis. "Quality of Drugs in Angola: An Innovative Research Project to Train Students Using Chromatographic Method". Paper presented in 11th International Congress of Educational Sciences and Development, 2023.
  3. Cardador, André; Afonso, Marta; Alves, Mariana; Pêgo, Ana C. ; Gaspar, Maria Manuela; Gozzelino, Raffaella; Gautheron, Jeremie; Rodrigues, Cecília. "RIPK3-dependent signalling and crosstalk hepatocytes-macrophages in MASLD progression". Paper presented in EASL SLD Summit 2023, 2023.
  4. Ferreira-Gonçalves, Tânia; Ana S. Viana; Ascensão, Lia; Ferreira-Santos, Pedro; Daniela Nunes; Elvira Fortunato; Rodrigo Martins; et al. "Morphological characterization of gold nanoparticles as versatile tools for photothermal therapy". Paper presented in FIT4NANO Workshop 2023, 2023.
  5. Francisco, Pedro; Amaral, Mariana M.; Maria, Rui; Ferreira-Gonçalves, Tânia; Viana, Ana S.; Catarino, José; Faísca, Rui Pedro Brás Martins ; et al. "From Fundamental to Translational Research of Metallic Nanoparticles: An Experimental Approach". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, 2023.
  6. Lopes, Joana; Ferreira-Gonçalves, Tânia; Ascensão, Lia; Viana, Ana S.; Carvalho, Lina; Catarino, José; Faísca, Rui Pedro Brás Martins ; et al. "In vitro and In Vivo Safety Assessment Of Gold Nanoparticles: A Broad Testing Array Checklist". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting, 2023.
  7. Neto, Íris; João Rocha; Ana S. Viana; Nádia Ribeiro; Correia, Isabel; Gaspar, Maria Manuela; Catarina P. Reis. Corresponding author: Catarina P. Reis. "Polymeric Nanoparticles as a Drug Delivery System for Metallodrugs in Colorectal Cancer Treatment: Characterization Studies". Paper presented in 14th iMed.ULisboa, 2023.
  8. Cardador, A; Afonso, Marta; Pêgo, Ana C. ; André Simão ; Gaspar, Maria Manuela; Rui Castro; Gozzelino, Raffaella; Rodrigues, Cecília. "RIPK3 modulates the immune microenvironment in toxic/dietary models of hepatocellular carcinoma". Paper presented in 14th iMed.ULisboa Postgraduate Students Meeting 2023, 2023.
  9. Cardador, A; Afonso, Marta; Pêgo, Ana C. ; André Simão ; Marques, Vanda; Gaspar, Maria Manuela; Rui Castro; Gozzelino, Raffaella; Rodrigues, Cecília. "RIPK3 impacts tumor burden and liver immunophenotype in toxic/dietary models of hepatocellular carcinoma". Paper presented in EASL Liver cancer summit 2023, 2023.
  10. Pinto S; DUARTE, Ana Patrícia; Botelho, Hugo; Gaspar, Maria Manuela; Ascenção L; Faísca P; Catarina Pinto Reis; Pacheco, Rita. "Albumin Nanoparticles of Natural Products: In Vitro and In Vivo Evaluation". Paper presented in 4th SPLC-CRS Young Scientists Meeting, 2023.
  11. Ferreira-Gonçalves, Tânia; Eduardo Costa; Coelho, João M. P.; Gaspar, Maria Manuela; Ascensão, Lia; Figueiredo, Isabel Vitória; David Ferreira; FERREIRA, HUGO; Reis, Catarina. "Gold nanoparticles: a promising next-generation tool for breast cancer photothermal therapy". Paper presented in IV Young Scientist Meeting of the Spanish Portuguese Local Chapter, Controlled Release Society (SPLC-CRS), 2023.
  12. Leonardo, A; André, Ana; Aguiar, Sandra I; Nogueira, Sara; Cavaco, Marco; São Braz, Berta; Tavares, Luis; et al. "Development of Immunoliposomes with Dual-Targeting Against Canine B-Cell Lymphoma.". Paper presented in CIISA CONGRESS 2022 - Innovation in Animal, Veterinary and Biomedical Research, 2022.
  13. Cardador, A; Afonso, Marta; Pêgo, Ana C. ; André Simão ; Gaspar, Maria Manuela; Gozzelino, Raffaella; Rodrigues, Cecília. "RIPK3 in the interface of immunogenic cell death and microenvironment in hepatocellular carcinoma". Paper presented in Champalimaud Reseach Symposium 2022, 2022.
  14. Cardador, A; Afonso, Marta; André Simão ; Gaspar, Maria Manuela; Rui Castro; Gozzelino, Raffaella; Rodrigues, Cecília. "Immune modulation by RIPK3 in NAFLD progression towards hepatocellular carcinoma". Paper presented in EASL NAFLD summit 2022, 2022.
  15. Vivien Pósa; Côrte-Real, Leonor; Isabel Romero; Figueira, Mariana; Reis, Catarina Pinto; Gaspar, Maria Manuela; Pessoa, João Costa; Correia, Isabel; Éva Enyedy. Corresponding author: Vivien Pósa. "Solution studies on the interaction of three new Schiff base 8-hydroxyquinolines with essential metal ions". Paper presented in 3rd European Nectar Conference (Ljubljana, Slovenia), 2022.
  16. Ferreira-Gonçalves, Tânia; Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Ana S. Viana; Ascensão, Lia; Lina Carvalho; et al. "Rosmarinic acid as key compound on the synthesis of gold nanoparticles for breast cancer photothermal therapy". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  17. Joana Lopes; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel Vitória; Cecília M. P. Rodrigues; FERREIRA, HUGO; David Ferreira; Ana S. Viana; et al. "Gold nanoparticles allied to photothermal therapy for the melanoma treatment". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  18. Ferreira-Gonçalves, Tânia; Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Ana S. Viana; Ascensão, Lia; Lina Carvalho; et al. "Rosmarinic acid for the synthesis of gold nanoparticles for a photothermal therapy approach". Paper presented in Controlled Release Society 2022 Annual Meeting & Expo, 2022.
  19. Cardador, A; Afonso, MB; Pêgo, Ana; Simão, AL; Gaspar, Maria Manuela; Castro, Rui; Gozzelino, Raffaella; Rodrigues, CMP. "Modulation of immune environment by RIPK3 in hepatocellular carcinoma". Paper presented in Jornadas Científicas ULisboa 2022, 2022.
  20. Oliveira Pinho, Jacinta; Matias, Mariana; Amaral, Joana D; Mendes, Eduarda; Perry, Maria Jesus; Storm, Gert; Gameiro, Ana P; Rodrigues, Cecília; Gaspar, Maria Manuela. "In vitro and in vivo validation of a new hybrid molecule loaded in liposomes for melanoma management". Paper presented in 17th Liposome Research Days, Catalyzing the Nanomedicine Revolution, 2022.
  21. Ferreira-Gonçalves, Tânia; Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Ana S. Viana; Ascensão, Lia; Lina Carvalho; et al. "Rosmarinic acid as one of the key intervenients on the bioproduction of gold nanoparticles: the first big step towards a photothermal therapy approach for breast cancer". Paper presented in Ciência 2022 ¿ Encontro com a Ciência e Tecnologia em Portugal, 2022.
  22. Joana Lopes; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel Vitória; Cecília M. P. Rodrigues; FERREIRA, HUGO; David Ferreira; Ana S. Viana; et al. "The added value of gold nanoparticles as photothermal enhancers for the management of superficial tumors". Paper presented in Ciência 2022 ¿ Encontro com a Ciência e Tecnologia em Portugal, 2022.
  23. Ferreira-Gonçalves, T; Gaspar, MM; Coelho, JMP; Marques, Vanda; Viana, AS; Ascensão, L; Carvalho, L; et al. "Rosmarinic acid as key compound on the synthesis of gold nanoparticle for breast cancer photothermal therapy". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting. Lisbon, Portugal, 2022.
  24. Joana Lopes; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel Vitória; Cecília M. P. Rodrigues; FERREIRA, HUGO; David Ferreira; Ana S. Viana; et al. "Proof-of-concept Study of Gold Nanoparticles Combined with NIR Laser Irradiation for the Treatment of Melanoma". Paper presented in Cutaneous Melanoma: from where to where?, from Liga Portuguesa Contra o Cancro, 2021.
  25. Penetra, Maria João; Francisco, Ana Paula; Pinho, Jacinta; Mendes, Eduarda; Rodrigues, Cecília MP; Amaral, Joana; Gaspar, Maria Manuela. "In vitro and in vivo evaluation of new hybrid molecules following its incorporation to a lipid-based nanosystem for the management of melanoma". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery 2021, 2021.
  26. Ferreira-Gonçalves, Tânia; Eduardo Costa; Inês Silvério; Coelho, João M. P.; Gaspar, Maria Manuela; Ascensão, Lia; Faísca, Rui Pedro Brás Martins ; et al. "Gold nanoparticles as part of a photothermal therapy system for breast cancer". Paper presented in 1st Symposium on Advanced Technologies for Drug Delivery, @DD21, 2021.
  27. Pimpão, Catarina; da Silva, Inês V.; Mósca, Andreia F; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, Annette; Aureliano, Manuel; Soveral, Graça. "Biophysical evaluation of polyoxotungstates on aquaporin-3 permeability and melanoma cell migration". Paper presented in 7th International Iberian Biophysics Congress, 2021.
  28. Camões, Sérgio P.; Bulut, Ozlem; Yazar, Volkan; Gaspar, Maria Manuela; Simões, Sandra; Ferreira, R; Vitorino, R; et al. "Exosomes from 3D-cultured MSCs are immunomodulatory and reveal healing proteins sustaining the promotion of cutaneous wound resolution". Paper presented in iMed.ULisboa meeting 2021, 2021.
  29. Diogo Almeida; Ferreira-Gonçalves, Tânia; Joana Lopes; Amaral, Mariana; Gaspar, Maria Manuela; Coelho, João M. P.; Reis, Catarina. "Photothermal Therapy: Synthesis and Characterization of Gold-Based Nanosystems". Paper presented in iMed.ULisboa Meeting 2021, 2021.
  30. Pinho, JO; da Silva, Inês V.; Amaral, Joana; Rodrigues, Cecília M.P.; Casini, A; Soveral, G.; Gaspar, Maria Manuela. "Advancing colon cancer treatment using pH-sensitive nanoliposomes loading a copper complex". Paper presented in iMed.ULisboa Meeting 2021. Faculty of Pharmacy, University of Lisboa, 2021.
  31. Matias, Mariana; Pinho, JO; Francisco, Ana; Eleutério, Carla; Perry, Maria Jesus; Mendes, Eduarda; Amaral, Joana; Rodrigues, Cecília MP; Gaspar, Maria Manuela. "Validation of a dual acting hybrid molecule loaded in liposomes in an A375 xenograft melanoma model". Paper presented in iMed.ULisboa Meeting 2021. Faculty of Pharmacy, University of Lisboa, 2021.
  32. Penetra, Maria João; Francisco, Ana Paula; Pinho, JO; Mendes, Eduarda; Rodrigues, Cecília MP; Amaral, Joana; Gaspar, Maria Manuela. "Improved selectivity and in vitro cytotoxic effects of hybrid molecules via liposomal delivery as a tool to fight melanoma". Paper presented in iMed.ULisboa Meeting 2021. Faculty of Pharmacy, University of Lisboa, 2021.
  33. Cruz, Nuno; Pinho, JO; Soveral, Graça; Matela, Nuno; Reis, Catarina; Gaspar, Maria Manuela. "Magnetic Targeting of a Novel Hybrid Nanosystem for Antitumoral Activity Enhancement". Paper presented in iMed.ULisboa Meeting 2021. Faculty of Pharmacy, University of Lisboa, 2021.
  34. Ferreira-Gonçalves, Tânia; Costa, Eduardo; Coelho J.M.P.; Gaspar, Maria Manuela; Ascensão L.; Faísca P.; Figueiredo I.V.; et al. "A step forward in breast cancer research: A preliminary photothermal approach using gold nanoparticles". Paper presented in iMed.ulisboa meeting 2021, 2021.
  35. Lopes, Joana; Ferreira-Gonçalves, Tânia; Amaral, Mariana; Coelho, João M.P.; Vieira, Pedro; Gaspar, Maria Manuela; Reis, Catarina. "Photothermal therapy and Nanotechnology: a new therapeutic strategy for the superficial tumors". Paper presented in Congresso Nacional dos Farmacêuticos e XIV Congresso Mundial dos Farmacêuticos de Língua Portuguesa, 2020.
  36. Mota, Francisco; Saramago, Ana; Matias, Mariana; Ferreira, Octávio; Silvestre, Samuel; Alves, Gilberto; Reis, Catarina; Gaspar, Maria Manuela. "A nanotechnological approach to improve the therapeutic potential of cytotoxic agents towards colon cancer". Paper presented in Congresso Nacional dos Farmacêuticos 2020 e XIV Congresso Mundial dos Farmacêuticos de Língua Portuguesa, 2020.
  37. Saramago, Ana; Mota, Francisco; Matias, Mariana; Ferreira, Octávio; Silvestre, Samuel; Alves, Gilberto; Reis, Catarina; Gaspar, Maria Manuela. "Lipid-based nanosystems of Biginelli compounds as a novel therapeutic tool for cancer". Paper presented in : Congresso Nacional dos Farmacêuticos 2020 e XIV Congresso Mundial dos Farmacêuticos de Língua Portuguesa, 2020.
  38. Grenha, Ana; Guerreiro, Filipa; Pontes, Jorge F.; Cruz, Joana; Rico, João; Gaspar, Maria Manuela; Rosa da Costa, Ana M. "Inhalable therapy of tuberculosis: Matching the delivery route with the infection route". Paper presented in 36º Congresso de Pneumologia, 2020.
  39. Lopes, Joana; Albino, Melissa; Matos, C. P.; Correia, Isabel; Reis, Catarina; Gaspar, Maria Manuela. "Liposomes as a tool to potentiate in vitro and in vivo the anti-tumor effect of new coordination compounds". Paper presented in 25th Anniversary¿ XIII Spanish-Portuguese Conference on Controlled Drug Release, 2020.
  40. Matias, Mariana; Oliveira Pinho, Jacinta; Francisco, Ana Paula; Eleutério, Carla V; Perry, Maria Jesus; Mendes, Eduarda; Amaral, Joana D; Rodrigues, Cecília; Gaspar, Maria Manuela. "An innovative liposomal hybrid molecule for the treatment of melanoma". Paper presented in XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  41. Ferreira, Magda; Ribeiro, I.A.C; Aires-da-Silva, Frederico; Aguiar, Sandra I; Gaspar, Maria Manuela. "Antibiotic-loaded Liposomes with High Potential Towards S. aureus Infections". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, Santiago de Compostela, Spain, 2020.
  42. Camões, Sérgio P; Gaspar, Maria Manuela; Rodrigues, Joana S; Carvalheiro, M; Simões, Sandra; Santos, Jorge M; Miranda, Joana P G. "Using the secretome of 3D-cultured mesenchymal stromal cells from the umbilical cord tissue for the treatment of rheumatoid arthritis". Paper presented in 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy, 2019.
  43. Ferreira, Magda; Pinto, Sandra; Aires-da-Silva, Frederico; António, Almeida; Aguiar, Sandra I; Bettencourt, Ana; Gaspar, Maria Manuela. "Antibiotic-lipid Based Nanosystems as a Tool for Staphylococcus aureus Associated Bone Infections". Paper presented in 38th Annual Meeting of the European Bone and Joint Infection Society, European Bone and Joint Infection Society (EBJIS), Antwerp, Belgium;, 2019.
  44. Ferreira, Magda; Pinto, Sandra; Ana F Bettencourt; Aguiar, Sandra I; Gaspar, Maria Manuela. "Liposomes as a Tool to Improve Antibacterial Effect of Antibiotics Towards S. aureus Infections". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research ¿ Phospholipid Research Center, Heidelberg, Germany;, 2019.
  45. Camões, Sérgio P.; Rodrigues, Joana S; Gaspar, Maria Manuela; Simões, Sandra; Ferreira, R.; Vitorino, R.; Santos, Jorge M.; Miranda, Joana P. G.. "Exploiting the exosomes from 3D cultures of human neonatal mesenchymal stem cells for the treatment of cutaneous wounds". Paper presented in EUROTOX 2019 ¿ 55th Congress of the European Societies of Toxicology, 2019.
    10.1016/j.toxlet.2019.09.002
  46. Matias, Mariana; Oliveira Pinho, Jacinta; Francisco, Ana Paula; Eleutério, Carla V; Perry, Maria Jesus; Amaral, Joana D; Rodrigues, Cecília; Gaspar, Maria Manuela. "A novel therapeutic approach for melanoma based in a new nanoformulated hybrid molecule". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  47. Ferreira, Magda; Pinto, Sandra; Ribeiro, I.A.; Aires-da-Silva, Frederico; Almeida, António; Bettencourt, Ana; Aguiar, Sandra I; Gaspar, Maria Manuela. "Antibiotic Liposomal Nanoformulations as a Tool to Inhibit Mature Staphylococcus aureus Biofilms". Paper presented in 11th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting, Faculdade de Farmácia da Universidade de Lisboa (FFUL);, 2019.
  48. Lopes, Joana; Albino, Melissa; Mularczyk, Dorota; Silva, Catarina Oliveira; Roberto, Amílcar; Gaspar, Maria Manuela; Viana, Ana; et al. "Phototherapy and Nanotechnology: a new therapeutic strategy for the treatment of superficial tumors". Paper presented in 11th i.Med.ULisboa Postgraduate Students Meeting and 4th i3DU Meeting, 2019.
  49. Melissa, Albino; Lopes, Joana; Matos, C. P.; Correia, Isabel; Reis, Catarina; Gaspar, Maria Manuela. "Nanoliposomal Formulations of New Cytotoxic Metallodrugs towards Murine Melanoma Cells". Paper presented in 11th i.Med.ULisboa Postgraduate Students Meeting and 4th i3DU Meeting, 2019.
  50. Oliveira Pinho, Jacinta; Matias, Mariana; Francisco, Ana Paula; Eleutério, Carla V; Perry, Maria Jesus; Amaral, Joana D; Rodrigues, Cecília; Gaspar, Maria Manuela. "Advancing Towards An Improved Melanoma Therapy Using A New Nanoformulated Hybrid Molecule". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  51. Camões, Sérgio P; Gaspar, Maria Manuela; Rodrigues, Joana S; Carvalheiro, M; Simões, Sandra; Santos, Jorge M; Miranda, Joana P G. "The use of 3D-cultured MSCs¿ secretome for rheumatoid arthritis treatment". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  52. Aguiar, Sandra I; Gaspar, Maria Manuela; André, Ana; Martins, Diana; Ferreira, Marta; Carvalheiro, Manuela; Neves, Vera; et al. "sdAb-immunoliposomes for brain targeting and drug delivery.". Paper presented in PEGS Europe, 2018.
  53. Gaspar, Maria Manuela; Rodrigues, Susana; Cunha, Ludmylla; Musacchio, Flávia; Pontes, Jorge F.; Guerreiro, Filipa; Grenha, Ana. "Gum-based microparticles: An inhalable platform for the treatment of lung tuberculosis". Paper presented in CRS Annual Meeting and Exposition, 2018.
  54. Sainz, Vanessa; Peres, Carina; Moura, Liane I F; Ana I. Matos; Viana, Ana S. or Viana, Ana; Lopes, João; Gaspar, Maria Manuela; et al. "Hybrid Lipid-Polymeric Nanoparticles for the Treatment of Melanoma by Strengthening the Host Immune Response". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3DU Meeting, 2017.
Journal article
  1. Trigo, Guilherme; Coelho, Mariana; Ferreira, Carolina Borges; Melosini, Matteo; Lehmann, Inês Sousa; Reis, Catarina P.; Gaspar, Maria Manuela; Santos, Susana. "Exploring the Biological Activity of Phytocannabinoid Formulations for Skin Health Care: A Special Focus on Molecular Pathways". International Journal of Molecular Sciences 25 23 (2024): 13142. https://doi.org/10.3390/ijms252313142.
    Published • 10.3390/ijms252313142
  2. Pinho, Jacinta O.; Coelho, Mariana; Pimpão, Catarina; Konwar, Jahnobi; Godinho-Santos, Ana; Noiva, Rute M.; Thomas, Sophie R.; et al. "Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent—In Vitro and In Vivo Studies". Pharmaceutics 16 12 (2024): 1566. https://doi.org/10.3390/pharmaceutics16121566.
    Published • 10.3390/pharmaceutics16121566
  3. Ana Iglesias-Mejuto; Rui Pinto; Pedro Faísca; José Catarino; João Rocha; Luisa Durães; Maria Manuela Gaspar; Catarina Pinto Reis; Carlos A. García-González. "3D-printed aerogels as theranostic implants monitored by fluorescence bioimaging". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2024.07.033.
    10.1016/j.bioactmat.2024.07.033
  4. Mariana Neves Amaral; Daniela Nunes; Elvira Fortunato; Rodrigo Martins; Carla Rodrigues; Pedro Faísca; Hugo Alexandre Ferreira; et al. "Gold nanoparticles for photothermal therapy – Influence of experimental conditions on the properties of resulting AuNPs". Journal of Drug Delivery Science and Technology (2024): https://doi.org/10.1016/j.jddst.2024.106215.
    10.1016/j.jddst.2024.106215
  5. Lopes, Joana; Rodrigues, Carla M.; Godinho-Santos, Ana; Coelho, João M.P.; Cabaço, Luís C.; Barral, Duarte C.; Faísca, Pedro; et al. "Combination of gold nanoparticles with near-infrared light as an alternative approach for melanoma management". International Journal of Pharmaceutics (2024): 124952. http://dx.doi.org/10.1016/j.ijpharm.2024.124952.
    Published • 10.1016/j.ijpharm.2024.124952
  6. Baioco, Karolyne Silva; Pereira, Raquel; Ferreira-Gonçalves, Tânia; Coelho, João M. P.; Gaspar, Maria Manuela; Reis, Catarina Pinto. "Combining Phototherapy and Gold-Based Nanomaterials: A Breakthrough in Basal Cell Carcinoma Treatment". International Journal of Molecular Sciences 25 21 (2024): 11494. http://dx.doi.org/10.3390/ijms252111494.
    Published • 10.3390/ijms252111494
  7. Ferreira, Magda; Pinto, Margarida; Aires-da-Silva, Frederico; Bettencourt, Ana; Gaspar, Maria Manuela; Aguiar, Sandra Isabel. "Rifabutin: a repurposed antibiotic with high potential against planktonic and biofilm staphylococcal clinical isolates". Frontiers in Microbiology 15 (2024): http://dx.doi.org/10.3389/fmicb.2024.1475124.
    Published • 10.3389/fmicb.2024.1475124
  8. Ferro, Cláudio; Matos, Ana I.; Serpico, Luigia; Fontana, Flavia; Chiaro, Jacopo; D'Amico, Carmine; Correia, Alexandra; et al. "Selenium Nanoparticles Synergize with a KRAS Nanovaccine against Breast Cancer". Advanced Healthcare Materials (2024): http://dx.doi.org/10.1002/adhm.202401523.
    Published • 10.1002/adhm.202401523
  9. Martins, Alexandra; Ferreira, Brigida C.; Gaspar, Maria Manuela; Vieira, Sandra; Lopes, Joana; Viana, Ana S.; Paulo, António; et al. "Enhanced Cytotoxicity against a Pancreatic Cancer Cell Line Combining Radiation and Gold Nanoparticles". Pharmaceutics 16 7 (2024): 900. http://dx.doi.org/10.3390/pharmaceutics16070900.
    Published • 10.3390/pharmaceutics16070900
  10. Gonçalves, Joana; Amaral, Joana D.; Capela, Rita; Perry, Maria de Jesus; Braga, Cláudia; Gaspar, Maria Manuela; Piedade, Fátima M.; et al. Corresponding author: Rodrigues, Cecília. "Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors". Cell Death Discovery 10 1 (2024): http://dx.doi.org/10.1038/s41420-024-02033-z.
    Published • 10.1038/s41420-024-02033-z
  11. Azevedo, Afonso; Coelho, Mariana P.; Pinho, Jacinta O.; Soares, Paula I.P.; Reis, Catarina P.; Borges, João P.; Gaspar, M. Manuela. "An alternative hybrid lipid nanosystem combining cytotoxic and magnetic properties as a tool to potentiate antitumor effect of 5-fluorouracil". Life Sciences 344 (2024): 122558. http://dx.doi.org/10.1016/j.lfs.2024.122558.
    Published • 10.1016/j.lfs.2024.122558
  12. Bastos, Joana C.; Manuela Gaspar, Maria; Pereiro, Ana B.; Araújo, João M.M.. "Role of ionic liquids in ibuprofen-based eutectic systems: Aqueous solubility, permeability, human cytotoxicity, hemolytic activity and anti-inflammatory activity". Journal of Molecular Liquids (2024): 124966. http://dx.doi.org/10.1016/j.molliq.2024.124966.
    Published • 10.1016/j.molliq.2024.124966
  13. Gomes, Susana M.; Gaspar, Maria Manuela; Coelho, João M. P.; Reis, Catarina; Susana M Gomes; Maria Manuela Gaspar; João MP Coelho; Catarina Pinto Reis. "Targeting Superficial Cancers with Gold Nanoparticles: A Review of Current Research". Therapeutic Delivery (2024): https://doi.org/10.1080/20415990.2024.2395249.
    Under revision • 10.1080/20415990.2024.2395249
  14. Sara Pinho; Tânia Ferreira-Gonçalves; Joana Lopes; Mariana Neves Amaral; Ana S. Viana; João M. P. Coelho; Maria Manuela Gaspar; Catarina Pinto Reis. "A Step Forward for the Treatment of Localized Prostate Cancer Using Gold Nanoparticles Combined with Laser Irradiation". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25084488.
    10.3390/ijms25084488
  15. Pinho, Sara; Ferreira-Gonçalves, Tânia; Amaral, Mariana; Joana L. Lopes; Gaspar, Maria Manuela; Coelho, João; Reis, Catarina Pinto; Viana, Ana. "A step forward for the treatment of localized prostate cancer using gold nanoparticles combined with Laser irradiation". International Journal of Molecular Sciences (2024):
    Accepted
  16. Pinho, Sara; Coelho, João; Gaspar, Maria Manuela; Reis, Catarina Pinto. "Advances in localized prostate cancer: a special focus on photothermal therapy". European Journal of Pharmacology. (2024):
    Under revision
  17. Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M.B.; et al. "Antimicrobial activity of prophage endolysins against critical Enterobacteriaceae antibiotic-resistant bacteria". International Journal of Pharmaceutics 651 (2024): 123758. http://dx.doi.org/10.1016/j.ijpharm.2023.123758.
    Published • 10.1016/j.ijpharm.2023.123758
  18. Ferreira-Gonçalves, Tânia; Nunes, Daniela; Fortunato, Elvira; Martins, Rodrigo; de Almeida, António P.; Carvalho, Lina; Ferreira, David; et al. "Rational approach to design gold nanoparticles for photothermal therapy: the effect of gold salt on physicochemical, optical and biological properties". International Journal of Pharmaceutics 650 (2024): 123659. http://dx.doi.org/10.1016/j.ijpharm.2023.123659.
    10.1016/j.ijpharm.2023.123659
  19. Pinho, Jacinta O.; Ferreira, Magda; Coelho, Mariana; Pinto, Sandra N.; Aguiar, Sandra I.; Gaspar, Maria Manuela. "Liposomal Rifabutin—A Promising Antibiotic Repurposing Strategy against Methicillin-Resistant Staphylococcus aureus Infections". Preprints.org 17 4 (2024): 470. https://publons.com/wos-op/publon/67636332/.
    Published • 10.20944/PREPRINTS202402.1186.V1
  20. Pelicano, Ana Catarina; Gaspar, Maria Manuela; Reis, Catarina P.; Araújo, Nuno A. M.; Conceição, Raquel C.; Godinho, Daniela M.. "In Vivo Measurements of Murine Melanoma's Complex Permittivity between 500 MHz – 8.5 GHz". IEEE Antennas and Wireless Propagation Letters (2024): 1-5. http://dx.doi.org/10.1109/lawp.2024.3460183.
    Published • 10.1109/lawp.2024.3460183
  21. Gonçalves, Joana; Amaral, JD; Capela, Rita; Perry, Maria Jesus; Braga, Cláudia; Gaspar, Maria Manuela; Piedade, Fátima; et al. Corresponding author: Rodrigues, Cecília.. "Necroptosis Induced by Ruthenium (II) Complexes as Mitochondrial Disruptors". (2024):
  22. Campaniço, André; Harjivan, Shrika G; Freitas, Elisabete; Serafini, Marco; Gaspar, Manuela M.; Capela, Rita; Gomes, Pedro; et al. "Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300410.
    Published • 10.1002/cmdc.202300410
  23. Guerreiro, Filipa; Pontes, Jorge F.; Gaspar, Maria Manuela; Rosa da Costa, Ana M.; Faleiro, Maria Leonor; Grenha, Ana. "Respirable konjac glucomannan microparticles as antitubercular drug carriers: Effects of in vitro and in vivo interactions". International Journal of Biological Macromolecules 248 (2023): 125838. http://dx.doi.org/10.1016/j.ijbiomac.2023.125838.
    Published • 10.1016/j.ijbiomac.2023.125838
  24. Coelho, Mariana Pinto; Duarte, Patrícia; Calado, Marta; Almeida, António J.; Reis, Catarina Pinto; Gaspar, M. Manuela. "The current role of cannabis and cannabinoids in health: A comprehensive review of their therapeutic potential". Life Sciences 329 (2023): 121838. http://dx.doi.org/10.1016/j.lfs.2023.121838.
    Published • 10.1016/j.lfs.2023.121838
  25. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136.
    Published • 10.3389/fvets.2023.1236136
  26. Joana Godinho-Pereira; Daniela Vaz; Inês Figueira; Joana Aniceto-Romão; Istvan Krizbai; Rui Malhó; João Rocha; et al. "Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery". Cells (2023): https://doi.org/10.3390/cells12162076.
    10.3390/cells12162076
  27. Rodrigues, Pedro M.; Afonso, Marta B.; Simão, André L.; Islam, Tawhidul; Gaspar, Maria M.; O'Rourke, Colm J.; Lewinska, Monika; et al. "miR-21-5p promotes NASH-related hepatocarcinogenesis". Liver International 43 10 (2023): 2256-2274. http://dx.doi.org/10.1111/liv.15682.
    Published • 10.1111/liv.15682
  28. Leonor Côrte-Real; Vivien Pósa; Matilde Martins; Raquel Colucas; Nóra V. May; Xavier Fontrodona; Isabel Romero; et al. "Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential". Inorganic Chemistry (2023): https://doi.org/10.1021/acs.inorgchem.3c01066.
    10.1021/acs.inorgchem.3c01066
  29. Pinho, Jacinta O.; Matias, Mariana; Godinho-Santos, Ana; Amaral, Joana D.; Mendes, Eduarda; Perry, Maria Jesus; Francisco, Ana Paula; Rodrigues, Cecília M.P.; Gaspar, M. Manuela. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics 640 (2023): 123011. http://dx.doi.org/10.1016/j.ijpharm.2023.123011.
    Published • 10.1016/j.ijpharm.2023.123011
  30. Neto, Íris; Rocha, João; Gaspar, Maria Manuela; Reis, Catarina P.. "Experimental Murine Models for Colorectal Cancer Research". Cancers 15 9 (2023): 2570. http://dx.doi.org/10.3390/cancers15092570.
    Published • 10.3390/cancers15092570
  31. Francisco, Pedro; Neves Amaral, Mariana; Neves, Afonso; Ferreira-Gonçalves, Tânia; Viana, Ana S.; Catarino, José; Faísca, Pedro; et al. "Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research". Gels 9 3 (2023): 200. http://dx.doi.org/10.3390/gels9030200.
    10.3390/gels9030200
  32. Joana Lopes; Tânia Ferreira-Gonçalves; Lia Ascensão; Ana S. Viana; Lina Carvalho; José Catarino; Pedro Faísca; et al. "Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/4/1120.
    10.3390/pharmaceutics15041120
  33. Hugo Luiz; Jacinta Oliveira Pinho; Maria Manuela Gaspar. "Advancing Medicine with Lipid-Based Nanosystems—The Successful Case of Liposomes". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020435.
    10.3390/biomedicines11020435
  34. David Pires; Manoj Mandal; Jacinta Pinho; Maria João Catalão; António José Almeida; José Miguel Azevedo-Pereira; Maria Manuela Gaspar; Elsa Anes. "Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by Mycobacterium tuberculosis and Helps Control the Phagosomal Replicative Niches". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021142.
    Published • 10.3390/ijms24021142
  35. Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021.
    Published • 10.1016/j.biopha.2022.114021
  36. Neto, Iris; Rocha, Joao; Gaspar, Maria Manuela; Reis, Catarina P.. "Experimental Murine Models for Colorectal Cancer Research". Cancers (2023): https://publons.com/wos-op/publon/57049008/.
    10.3390/CANCERS15092570
  37. Francisco, Pedro; Neves Amaral, Mariana; Neves, Afonso; Ferreira-Goncalves, Tania; Viana, Ana S.; Catarino, Jose; Faisca, Pedro; et al. "Pluronic((R)) F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research". Gels (2023): https://publons.com/wos-op/publon/56285067/.
    10.3390/GELS9030200
  38. Pinho, Jacinta O.; Matias, Mariana; Godinho-Santos, Ana; Amaral, Joana D.; Mendes, Eduarda; Perry, Maria Jesus; Francisco, Ana Paula; Rodrigues, Cecilia M. P.; Gaspar, M. Manuela. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics (2023): https://publons.com/wos-op/publon/61305611/.
    10.1016/J.IJPHARM.2023.123011
  39. Mariana Neves Amaral; Pedro Faísca; Hugo Alexandre Ferreira; Maria Manuela Gaspar; Catarina Pinto Reis. "Current Insights and Progress in the Clinical Management of Head and Neck Cancer". Cancers (2022): https://doi.org/10.3390/cancers14246079.
    10.3390/cancers14246079
  40. Nádia Ribeiro; Pedro Franco Farinha; Jacinta O. Pinho; Hugo Luiz; János P. Mészáros; Adelino Galvão; João Costa Pessoa; et al. "Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/12/2583.
    10.3390/pharmaceutics14122583
  41. Pinto, Sofia; Gaspar, Maria Manuela; Ascensão, Lia; Faísca, Pedro; Reis, Catarina Pinto; Pacheco, Rita. "Nanoformulation of Seaweed Eisenia bicyclis in Albumin Nanoparticles Targeting Cardiovascular Diseases: In Vitro and In Vivo Evaluation". Marine Drugs 20 10 (2022): 608. http://dx.doi.org/10.3390/md20100608.
    10.3390/md20100608
  42. Lopes, Joana; Rodrigues, Cecília M. P.; Gaspar, Maria Manuela; Reis, Catarina Pinto; Rodrigues, Cecilia M. P.. "Melanoma Management: From Epidemiology to Treatment and Latest Advances". Cancers 14 19 (2022): 4652. http://dx.doi.org/10.3390/cancers14194652.
    Published • 10.3390/cancers14194652
  43. Morais, Diana; Tanoeiro, Luís; Marques, Andreia; Gonçalves, Tiago; Duarte, Aida; Matos, António; Vital, Joana; et al. Corresponding author: Tanoeiro, Luis. "Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aeruginosa Model". International Journal of Molecular Sciences 23 17 (2022): 10143. http://dx.doi.org/10.3390/ijms231710143.
    10.3390/ijms231710143
  44. Joana Lopes; Cecília M. P. Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis. "How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091817.
    10.3390/pharmaceutics14091817
  45. Bastos, Joana C.; Vieira, Nicole S. M.; Gaspar, Maria Manuela; Pereiro, Ana B.; Araújo, João M. M.. "Human Cytotoxicity, Hemolytic Activity, Anti-Inflammatory Activity and Aqueous Solubility of Ibuprofen-Based Ionic Liquids". Sustainable Chemistry 3 3 (2022): 358-375. http://dx.doi.org/10.3390/suschem3030023.
    Published • 10.3390/suschem3030023
  46. Ferreira-Gonçalves, Tânia; Iglesias-Mejuto, Ana; Linhares, Teresa; Coelho, João M. P.; Vieira, Pedro; Faísca, Pedro; Catarino, José; et al. "Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy". Gels 8 8 (2022): 485. http://dx.doi.org/10.3390/gels8080485.
    Published • 10.3390/gels8080485
  47. Nádia Ribeiro; Melissa Albino; Andreia Ferreira; Cristina Escrevente; Duarte C. Barral; João Costa Pessoa; Catarina Pinto Reis; Maria Manuela Gaspar; Isabel Correia. "Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model". International Journal of Molecular Sciences 23 12 (2022): 6728-6728. https://doi.org/10.3390/ijms23126728.
    Published • 10.3390/ijms23126728
  48. Cruz, Maria Eugénia Meirinhos; Corvo, Maria Luísa; Martins, Maria Bárbara; Simões, Sandra; Gaspar, Maria Manuela. "Liposomes as Tools to Improve Therapeutic Enzyme Performance". Pharmaceutics 14 3 (2022): 531. http://dx.doi.org/10.3390/pharmaceutics14030531.
    Published • 10.3390/pharmaceutics14030531
  49. Gaspar, Maria Manuela. "The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment". Molecules 12 71 (2022): https://doi.org/10.3390/biom12010071.
    Published • 10.3390/biom12010071
  50. Sérgio P Camões; Ozlem Bulut; Volkan Yazar; Manuela Gaspar; Sandra Simões; Rita Ferreira; Rui Vitorino; et al. "3D-MSCs A151 ODN-Loaded Exosomes Are Immunomodulatory And Reveal A Proteomic Cargo That Sustains Wound Resolution". Journal of Advanced Research (2022): https://doi.org/10.1016/j.jare.2022.01.013.
    10.1016/j.jare.2022.01.013
  51. Cruz, Ana Filipa A.; Fonseca, Nuno A. B.; Malheiro, Ana Rita; Melo, Joana B.; Gaspar, Maria Manuela; Fernandes, Rui; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno. "Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature of drug interaction beyond bulk tumor cells". European Journal of Pharmaceutics and Biopharmaceutics (2022): https://publons.com/wos-op/publon/50022955/.
    10.1016/J.EJPB.2022.01.006
  52. Matos, Cristina P.; Albino, Melissa; Lopes, Joana; Viana, Ana Silveira; Corte-Real, Leonor; Mendes, Filipa; Pessca, Joao Costa; et al. "New iron(III) anti-cancer aminobisphenolate/phenanthroline complexes: Enhancing their therapeutic potential using nanoliposomes". International Journal of Pharmaceutics (2022): https://publons.com/wos-op/publon/53634082/.
    10.1016/J.IJPHARM.2022.121925
  53. Pedro Farinha; João M. P. Coelho; Catarina Pinto Reis; Maria Manuela Gaspar. "A Comprehensive Updated Review on Magnetic Nanoparticles in Diagnostics". Nanomaterials (2021): https://doi.org/10.3390/nano11123432.
    10.3390/nano11123432
  54. Aguiar, Sandra Isabel; Dias, Joana N. R.; André, Ana Santos; Silva, Marta Lisete; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; et al. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics 13 10 (2021): 1598. http://dx.doi.org/10.3390/pharmaceutics13101598.
    Published • 10.3390/pharmaceutics13101598
  55. Gaspar, Maria Manuela; Jacinta O. Pinho; Maria de Jesus Rocha Perry; Ana Paula Francisco; Eduarda Mendes; Maria João Penetra; Granada Margarida; et al. "Sulfur analogs of tyrosine in the development of triazene hybrid compounds: a new strategy against melanoma". ACS Medicinal Chemistry Letters (2021): https://doi.org/10.1021/acsmedchemlett.1c00252.
    Accepted • 10.1021/acsmedchemlett.1c00252
  56. Fernández-Paz, Estefanía; Feijoo-Siota, Lucía; Gaspar, Maria Manuela; Csaba, Noemi; Remuñán-López, Carmen. "Microencapsulated Chitosan-Based Nanocapsules: A New Platform for Pulmonary Gene Delivery". Pharmaceutics 13 9 (2021): 1377. http://dx.doi.org/10.3390/pharmaceutics13091377.
    Published • 10.3390/pharmaceutics13091377
  57. Oliveira, Sara R.; Dionísio, Pedro A.; Gaspar, Maria M.; Correia Guedes, Leonor; Coelho, Miguel; Rosa, Mário M.; Ferreira, Joaquim J.; Amaral, Joana D.; Rodrigues, Cecília M. P.. "miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.661461.
    Published • 10.3389/fcell.2021.661461
  58. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita G. Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22105289.
    10.3390/ijms22105289
  59. Mota, Ana Henriques; Prazeres, Inês; Mestre, Henrique; Bento-Silva, Andreia; Rodrigues, Maria João; Duarte, Noélia; Serra, Ana Teresa; et al. "A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract". Pharmaceuticals 14 5 (2021): 467. http://dx.doi.org/10.3390/ph14050467.
    Published • 10.3390/ph14050467
  60. Joana Lopes; Tânia Ferreira-Gonçalves; Isabel V. Figueiredo; Cecília M. P. Rodrigues; Hugo Ferreira; David Ferreira; Ana S. Viana; et al. "Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma". Biomolecules 11 4 (2021): 511-511. https://doi.org/10.3390/biom11040511.
    Published • 10.3390/biom11040511
  61. Mariana Amaral; Adília J. Charmier; Ricardo A. Afonso; José Catarino; Pedro Faísca; Lina Carvalho; Lia Ascensão; et al. "Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A Step Forward". Cancers 13 6 (2021): 1242-1242. https://doi.org/10.3390/cancers13061242.
    Published • 10.3390/cancers13061242
  62. Gaspar, Maria Manuela; Pinho, J.O.; da Silva, I.V.; Amaral, J.D.; Rodrigues, C.M.P.; Casini, A.; Soveral, G.; et al. "Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management". Int. Journal of Pharmaceutics 599 (2021): https://drive.google.com/file/d/1OZULw-_5dEJ4o23lQt0kL04EBriAPQlm/view?usp=sharing.
    Published • 10.1016/j.ijpharm.2021.120463
  63. Nicole S. M. Vieira; Ana L. S. Oliveira; João M. M. Araújo; M. Manuela Gaspar; Ana B. Pereiro. "Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids". Sustainable Chemistry (2021): https://doi.org/10.3390/suschem2010008.
    Published • 10.3390/suschem2010008
  64. Magda Ferreira; Sandra N. Pinto; Frederico Aires-da-Silva; Ana Bettencourt; Sandra I. Aguiar; Maria Manuela Gaspar; Ferreira, Magda; et al. "Liposomes as a Nanoplatform to Improve the Delivery of Antibiotics into Staphylococcus aureus Biofilms". Pharmaceutics 13 3 (2021): 321-321. https://doi.org/10.3390/pharmaceutics13030321.
    Published • 10.3390/pharmaceutics13030321
  65. Pedro Farinha; Jacinta O. Pinho; Mariana Matias; M. Manuela Gaspar; Farinha, Pedro; Pinho, Jacinta O.; Matias, Mariana; Gaspar, M. Manuela. "Nanomedicines in the treatment of colon cancer: a focus on metallodrugs". Drug Delivery and Translational Research (2021): https://doi.org/10.1007/s13346-021-00916-7.
    Published • 10.1007/s13346-021-00916-7
  66. Ferreira, Magda; Ogren, Maria; Dias, Joana N. R.; Silva, Marta; Gil, Solange; Tavares, Luis; Aires-da-Silva, Frederico; et al. "Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance". Molecules 26 7 (2021): 2047-2047. https://publons.com/publon/43429622/.
    Published • 10.3390/MOLECULES26072047
  67. Quitério, M.; Simões, S.; Ascenso, A.; Carvalheiro, M.; Leandro, A.P.; Correia, I.; Viana, A.S.; et al. "Development of a topical insulin polymeric nanoformulation for skin burn regeneration: An experimental approach". International Journal of Molecular Sciences 22 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85104133017&partnerID=MN8TOARS.
    10.3390/ijms22084087
  68. Fonseca, N.A.; Gregório, A.C.; Mendes, V.M.; Lopes, R.; Abreu, T.; Gonçalves, N.; Manadas, B.; et al. "GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure". Nano Today 37 (2021): 101095. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100993071&partnerID=MN8TOARS.
    Published • 10.1016/j.nantod.2021.101095
  69. Gaspar, Maria Manuela; Matias, Mariana; Pinho, Jacinta O.; Penetra, Maria João; Campos, Gonçalo; Reis, Catarina Pinto; Gaspar, Maria Manuela. "The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval". Cells 10 11 (2021): 3088. https://doi.org/ 10.3390/cells10113088.
    Published • 10.3390/cells10113088
  70. da Silva, I. V.; Pimpao, C.; Mosca, A. F.; Pinho, J. O.; Gaspar, M.; Gumerova, N. I.; Rompel, A.; Aureliano, M.; Soveral, G.. "Polyoxotungstates inhibit aquaporin-3 and impair melanoma cell migration". FEBS Open Bio (2021): https://publons.com/wos-op/publon/49554518/.
  71. Mariana Amaral; Ana B Pereiro; Maria Manuela Gaspar; Catarina Pinto Reis. "Recent advances in ionic liquids and nanotechnology for drug delivery". Nanomedicine (2020): https://doi.org/10.2217/nnm-2020-0340.
    Published • 10.2217/nnm-2020-0340
  72. Afonso, Marta B; Rodrigues, Pedro M; Mateus-Pinheiro, Miguel; Simão, André L; Gaspar, Maria M; Majdi, Amine; Arretxe, Enara; et al. "RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease". Gut 70 12 (2020): 2359-2372. http://dx.doi.org/10.1136/gutjnl-2020-321767.
    Published • 10.1136/gutjnl-2020-321767
  73. Eduardo Costa; Tânia Ferreira-Gonçalves; Miguel Cardoso; João M. P. Coelho; Maria Manuela Gaspar; Pedro Faísca; Lia Ascensão; et al. "A Step Forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach". International Journal of Molecular Sciences 21 24 (2020): 1-28. https://doi.org/10.3390/ijms21249681.
    Open access • Published • 10.3390/ijms21249681
  74. Gaspar, Maria Manuela. "Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations". Pharmaceutics 12 12 (2020): 1181-1181. http://dx.doi.org/10.3390/pharmaceutics12121181.
    10.3390/pharmaceutics12121181
  75. Mota, Ana Henriques; Andrade, Joana M.; Rodrigues, Maria João; Custódio, Luísa; Bronze, Maria Rosário; Duarte, Noélia; Baby, André; et al. "Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses". Industrial Crops and Products 154 (2020): 112709. http://dx.doi.org/10.1016/j.indcrop.2020.112709.
    Published • 10.1016/j.indcrop.2020.112709
  76. Joana Lopes; João Miguel Pinto Coelho; Pedro Manuel Cardoso Vieira; Ana Silveira Viana; Maria Manuela Gaspar; Catarina Reis. "Preliminary Assays towards Melanoma Cells Using Phototherapy with Gold-Based Nanomaterials". Nanomaterials 10 8 (2020): 1536-1536. https://doi.org/10.3390/nano10081536.
    Published • 10.3390/nano10081536
  77. Ferreira, Magda; Aguiar, Sandra; Bettencourt, Ana; Gaspar, Maria Manuela. "Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors". Drug Delivery and Translational Research 11 (2020): 72-85. http://dx.doi.org/10.1007/s13346-020-00791-8.
    Published • 10.1007/s13346-020-00791-8
  78. Gaspar, Maria Manuela; Cruz, N.; Pinho, J.O.; Soveral, G.; Ascensão, L.; Matela, N.; Reis, C.; Gaspar, M.M.. "A novel hybrid nanosystem integrating cytotoxic and magnetic properties as a tool to potentiate melanoma therapy". Nanomaterials 10 4 (2020): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083837690&partnerID=MN8TOARS.
    Published • 10.3390/nano10040693
  79. Gaspar, Maria Manuela; Catarina Pimpão; Inês V. da Silva; Andreia F. Mósca; Jacinta O. Pinho; Maria Manuela Gaspar; Nadiia I. Gumerova; et al. "The Aquaporin-3 Inhibiting Potential of Polyoxotungstates". International Journal of Molecular Sciences 21 7 (2020): 1-13. https://doi.org/10.3390/ijms21072467.
    Open access • Published • 10.3390/ijms21072467
  80. Castañeda-Loaiza, Viana; Placines, Chloé; Rodrigues, Maria João; Pereira, Catarina; Zengin, Gokhan; Uysal, Ahmet; Jeko, József; et al. "If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products". Industrial Crops and Products 144 (2020): 112005. http://dx.doi.org/10.1016/j.indcrop.2019.112005.
    Published • 10.1016/j.indcrop.2019.112005
  81. Grenha, Ana; Alves, Ana D.; Guerreiro, Filipa; Pinho, Jacinta; Simões, Sandra; Almeida, António José; Gaspar, Maria Manuela. "Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin: Therapeutic assessment in a murine model of tuberculosis infection". European Journal of Pharmaceutics and Biopharmaceutics 147 (2020): 38-44. http://dx.doi.org/10.1016/j.ejpb.2019.11.009.
    Published • 10.1016/j.ejpb.2019.11.009
  82. Amaral, M.; Martins, A.S.; Catarino, J.; Faísca, P.; Kumar, P.; Pinto, J.F.; Pinto, R.; et al. "How can biomolecules improve mucoadhesion of oral insulin? A comprehensive insight using ex-vivo, in silico, and in vivo models". Biomolecules 10 5 (2020): 1-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083970308&partnerID=MN8TOARS.
    Open access • Published • 10.3390/biom10050675
  83. Afonso, Marta B.; Miguel Rodrigues, Pedro; Mateus-Pinheiro, Miguel; Simao, Andre L.; Gaspar, Maria Manuela; Majdi, Amine; Ratziu, Vlad; et al. "Hepatic RIPK3 signalling differentially modulates lipid metabolism and inflammation in non-alcoholic fatty liver disease". Journal of Hepatology (2020): https://publons.com/wos-op/publon/53791131/.
  84. Mateus-Pinheiro, Miguel; Afonso, Marta B.; Miguel Rodrigues, Pedro; Simao, Andre L.; Gaspar, Maria Manuela; Di-Tommaso, Sylvaine; Raymond, Anne-Aurelie; et al. "The role of RIPK3 in non-alcoholic fatty liver disease: a multi-omics perspective". Journal of Hepatology (2020): https://publons.com/wos-op/publon/53791133/.
  85. Miguel Rodrigues, Pedro; Afonso, Marta B.; Simao, Andre; Islam, Tawhidul; Gaspar, Maria Manuela; Rourke, Colm O.; Andersen, Jesper; et al. "mIR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD". Journal of Hepatology (2020): https://publons.com/wos-op/publon/53791134/.
  86. Gaspar, Maria Manuela; Amaral, Mariana; Reis, Catarina Pinto; Ricardo A. Afonso; Amaral, M.; Afonso, R.A.; Gaspar, M.M.; Reis, C.P.. "ANAPLASTIC THYROID CANCER: HOW FAR CAN WE GO?". EXCLI Journal 19 (2020): 800-812. http://dx.doi.org/10.17179/excli2020-2257.
    Published • 10.17179/excli2020-2257
  87. Santos-Rebelo, Ana; Kumar, Pradeep; Pillay, Viness; Choonara, Yahya E.; Eleutério, Carla; Figueira, Mariana; Viana, Ana S.; et al. "Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells". Cancers 11 11 (2019): 1733. http://dx.doi.org/10.3390/cancers11111733.
    Published • 10.3390/cancers11111733
  88. Jacinta Oliveira Pinho; Mariana Matias; Maria Manuela Gaspar. "Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma". Nanomaterials (2019): https://doi.org/10.3390/nano9101455.
    Published • 10.3390/nano9101455
  89. Dogbe, Marina G.; Mafilaza, Ambinintsoa Yattussia; Eleutério, Carla Vânia; Cabral-Marques, Helena; Simões, Sandra; Gaspar, Maria Manuela. "Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation". Pharmaceutics 11 10 (2019): 521. http://dx.doi.org/10.3390/pharmaceutics11100521.
    Published • 10.3390/pharmaceutics11100521
  90. Miranda, Joana P.; Camões, Sérgio P.; Gaspar, Maria M.; Rodrigues, Joana S.; Carvalheiro, Manuela; Bárcia, Rita N.; Cruz, Pedro; et al. "The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis". Frontiers in Immunology 10 18 (2019): 1-14. http://dx.doi.org/10.3389/fimmu.2019.00018.
    Published • 10.3389/fimmu.2019.00018
  91. Silva, C.O.; Pinho, J.O.; Lopes, J.M.; Almeida, A.J.; Gaspar, M.M.; Reis, C.. "Current trends in cancer nanotheranostics: Metallic, polymeric, and lipid-based systems". Pharmaceutics 11 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060687076&partnerID=MN8TOARS.
    Published • 10.3390/pharmaceutics11010022
  92. Mota, A.H.; Direito, R.; Carrasco, M.P.; Rijo, P.; Ascensão, L.; Viana, A.S.; Rocha, J.; et al. "Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis". International Journal of Pharmaceutics 559 (2019): 13-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060554783&partnerID=MN8TOARS.
    Published • 10.1016/j.ijpharm.2019.01.017
  93. Direito, R.; Reis, C.; Roque, L.; Gonçalves, M.; Sanches-Silva, A.; Gaspar, M.M.; Pinto, R.; et al. "Phytosomes with persimmon (Diospyros kaki l.) extract: Preparation and preliminary demonstration of in vivo tolerability". Pharmaceutics 11 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85069871346&partnerID=MN8TOARS.
    Published • 10.3390/pharmaceutics11060296
  94. Afonso, Marta B.; Rodrigues, Pedro Miguel; Simao, Andre; Gaspar, Maria Manuela; Castro, Rui E.; Rodrigues, Cecilia M. P.; Simão, André; Rodrigues, Cecília M.P.. "RIP3-dependent signalling exerts divergent effects on liver steatosis and carcinogenesis in experimental non-alcholic fatty liver disease". Journal of Hepatology 70 1 (2019): e518. https://publons.com/publon/30227153/.
    Published • 10.1016/S0618-8278(19)31023-0
  95. Pinho, J.O.; Amaral, J.D.; Castro, R.E.; Rodrigues, C.M.P.; Casini, A.; Soveral, G.; Gaspar, M.M.. "Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models". Nanomedicine 14 7 (2019): 835-850. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063769714&partnerID=MN8TOARS.
    10.2217/nnm-2018-0388
  96. Dionísio, P.A.; Oliveira, S.R.; Gaspar, M.M.; Gama, M.J.; Castro-Caldas, M.; Amaral, J.D.; Rodrigues, C.M.P.; et al. "Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease". Cell Death and Disease 10 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074563105&partnerID=MN8TOARS.
    Published • 10.1038/s41419-019-2078-z
  97. Camoes, S. P.; Rodrigues, S.; Gaspar, M.; Simoes, S.; Ferreira, R.; Barros, A.; Vitorino, R.; et al. "The role of exosomes from human MSC 3D cultures in wound healing". Toxicology Letters (2019): https://publons.com/wos-op/publon/31439200/.
  98. Sainz, Vanessa; Moura, Liane I F; Peres, Carina; Matos, Ana I; Viana, Ana S; Wagner, Angela M; Vela Ramirez, Julia E; et al. "alpha-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effectin melanoma.". Acta biomaterialia (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:29940370&KeyUID=MEDLINE:29940370.
    Published • 10.1016/j.actbio.2018.06.029
  99. Bhattacharjee, S.; Gaspar, M.M.; Scholz, D.; Almeida, A.J.; Brayden, D.J.. "Track analysis of the passage of rhodamine-labeled liposomes across porcine jejunal mucus in a microchannel device". Therapeutic Delivery 9 6 (2018): 419-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046839741&partnerID=MN8TOARS.
    Published • 10.4155/tde-2017-0116
  100. Santos-Rebelo, A.; Garcia, C.; Eleutério, C.; Bastos, A.; Coelho, S.C.; Coelho, M.A.N.; Molpeceres, J.; et al. "Development of parvifloron D-loaded smart nanoparticles to target pancreatic cancer". Pharmaceutics 10 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056568086&partnerID=MN8TOARS.
    Published • 10.3390/pharmaceutics10040216
  101. Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Gaspar, M.M.; Carvalho, T.; Borralho, P.; Bañales, J.M.; Castro, R.E.; Rodrigues, C.M.P.. "MiRNA-21 ablation protects against liver injury and necroptosis in cholestasis". Cell Death and Differentiation 25 5 (2018): 857-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037678048&partnerID=MN8TOARS.
    10.1038/s41418-017-0019-x
  102. Afonso, M. B.; Rodrigues, P. M.; Simao, A.; Gaspar, M. M.; Castro, R. E.; Rodrigues, C. M. P.. "RIP3-dependent signalling contributes to non-alcoholic fatty liver disease-related hepatocarcinogenesis". Journal of Hepatology (2018): https://publons.com/publon/30227164/.
    10.1016/S0168-8278(18)30939-5
  103. Afonso, Marta B.; Rodrigues, Pedro M.; Simao, Andre L.; Santos, Andre A.; Gaspar, Maria M.; Castro, Rui E.; Rodrigues, Cecilia M. P.. "The role of necroptosis in non-alcoholic fatty liver disease-related carcinogenesis". Free Radical Biology and Medicine (2018): https://publons.com/wos-op/publon/11124647/.
    10.1016/J.FREERADBIOMED.2018.04.115
  104. Simoes, Sandra; Carvalheiro, Manuela; Gaspar, Maria. "Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management". Current Pharmaceutical Design 22 43 (2017): 6577-6586. http://dx.doi.org/10.2174/1381612822666160701083812.
    Published • 10.2174/1381612822666160701083812
  105. Sousa, A.; Santos, F.; Gaspar, M.M.; Calado, S.; Pereira, J.D.; Mendes, E.; Francisco, A.P.; Perry, M.J.. "The selective cytotoxicity of new triazene compounds to human melanoma cells". Bioorganic and Medicinal Chemistry 25 15 (2017): 3900-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020296185&partnerID=MN8TOARS.
    Published • 10.1016/j.bmc.2017.04.049
  106. Bárcia, R.N.; Santos, J.M.; Teixeira, M.; Filipe, M.; Pereira, A.R.S.; Ministro, A.; Água-Doce, A.; et al. "Umbilical cord tissue–derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing". Cytotherapy 19 3 (2017): 360-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009396582&partnerID=MN8TOARS.
    Published • 10.1016/j.jcyt.2016.11.008
  107. Gaspar, D.P.; Gaspar, M.M.; Eleutério, C.V.; Grenha, A.; Blanco, M.; Gonçalves, L.M.D.; Taboada, P.; Almeida, A.J.; Remunán-López, C.. "Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery". Molecular Pharmaceutics 14 9 (2017): 2977-2990. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028830756&partnerID=MN8TOARS.
    Published • 10.1021/acs.molpharmaceut.7b00169
  108. Afonso, M. B.; Rodrigues, P. M.; Simao, A. L.; Gaspar, M. M.; Castro, R. E.; Rodrigues, C. M. P.. "miRNA-21-deficiency reduces liver injury, fibrosis and necroptosis in cholestatic bile duct-ligated mice". Journal of Hepatology 66 1 (2017): S555-S555. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000401056601365&KeyUID=WOS:000401056601365.
  109. Afonso, Marta B; Rodrigues, Pedro M; Simão, André L; Ofengeim, Dimitry; Carvalho, Tânia; Amaral, Joana D; Gaspar, Maria M; et al. "Activation of necroptosis in human and experimental cholestasis". Cell Death & Disease 7 9 (2016): e2390-e2390. http://dx.doi.org/10.1038/cddis.2016.280.
    10.1038/cddis.2016.280
  110. Manuela Gaspar, Maria; Susana Calado; Carla V Eleutério; Eduarda Mendes; Maria de Jesus Rocha Perry; Ana Paula Francisco. "Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma". Journal of Nanoscience with Advanced Technology 1 4 (2016): 1-9. http://dx.doi.org/10.24218/jnat.2016.16.
    Published • 10.24218/jnat.2016.16
  111. Lopes, R.M.; Pereira, J.; Esteves, M.A.; Gaspar, M.M.; Carvalheiro, M.; Eleutério, C.V.; Gonçalves, L.; et al. "Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections". Nanomedicine 11 2 (2016): 153-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952660305&partnerID=MN8TOARS.
    Published • 10.2217/nnm.15.190
  112. Nave, M.; Castro, R.E.; Rodrigues, C.M.P.; Casini, A.; Soveral, G.; Gaspar, M.M.. "Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells". Nanomedicine 11 14 (2016): 1817-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978525644&partnerID=MN8TOARS.
    10.2217/nnm-2016-0086
  113. Camões, S.P.; Santos, J.M.; Gaspar, M.M.; Simões, S.I.; Bárcia, R.N.; Cruz, H.; Cruz, P.; Castro, M.; Miranda, J.P.. "Human neonatal mesenchymal stem cell spheroids-conditioned medium accelerates skin regeneration". Toxicology Letters 238 2 (2015): S376-S377. http://dx.doi.org/10.1016/j.toxlet.2015.08.1075.
    Published • 10.1016/j.toxlet.2015.08.1075
  114. Santos, J.M.; Camões, S.P.; Filipe, E.; Cipriano, M.; Barcia, R.N.; Filipe, M.; Teixeira, M.; et al. "Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing". Stem Cell Research and Therapy 6 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930684508&partnerID=MN8TOARS.
    Published • 10.1186/s13287-015-0082-5
  115. Gaspar, M.M.; Calado, S.; Pereira, J.; Ferronha, H.; Correia, I.; Castro, H.; Tomás, A.M.; Cruz, M.E.M.. "Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems". Nanomedicine: Nanotechnology, Biology, and Medicine 11 7 (2015): 1851-1860. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942118843&partnerID=MN8TOARS.
    Published • 10.1016/j.nano.2015.06.008
  116. Bárcia, R. N.; Santos, J. M.; Filipe, M.; Teixeira, M.; Martins, J. P.; Almeida, J.; Água-Doce, A.; et al. "What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?". Stem Cells International 2015 (2015): 1-14. http://dx.doi.org/10.1155/2015/583984.
    Published • 10.1155/2015/583984
  117. Silva, J.M.; Zupancic, E.; Vandermeulen, G.; Oliveira, V.G.; Salgado, A.; Videira, M.; Gaspar, M.; et al. "In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model". Journal of Controlled Release 198 (2015): 91-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-84918557500&partnerID=MN8TOARS.
    10.1016/j.jconrel.2014.11.033
  118. Gomes, M.; Gaspar, M.; Carvalheiro, M.; Cruz, M. E. M.; Vale, F. F.. "FUSOGENIC LIPOSOMES AS PROMISING DELIVERY SYSTEMS AGAINST HELICOBACTER PYLORI". Helicobacter 19 (2014): 137-138. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341623900226&KeyUID=WOS:000341623900226.
    Published
  119. Lopes, R.M.; Gaspar, M.M.; Pereira, J.; Eleutério, C.V.; Carvalheiro, M.; Almeida, A.J.; Cruz, M.E.M.. "Liposomes versus Lipid Nanoparticles: Comparative Study of Lipid-Based Systems as Oryzalin Carriers for the Treatment of Leishmaniasis". Journal of Biomedical Nanotechnology 10 12 (2014): 3647-3657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928499115&partnerID=MN8TOARS.
    10.1166/jbn.2014.1874
  120. Santos, Jorge M; Bárcia, Rita N; Simões, Sandra I; Gaspar, Manuela M; Calado, Susana; Água-Doce, Ana; Almeida, Sílvia CP; et al. "The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis". Journal of Translational Medicine 11 1 (2013): 1-13. http://dx.doi.org/10.1186/1479-5876-11-18.
    Published • 10.1186/1479-5876-11-18
  121. Gaspar, Maria. "Nanoformulations with specific affinity to human melanoma". Pigment Cell & Melanoma Research Volume 26:E20-E21 (2013):
    Published
  122. Gomes, M.; Lehours, P.; Gaspar, M.; Colla Carvalheiro, M.; Vale, F. F.. "LIPOSOMES AS DRUG DELIVERY SYSTEMS AGAINST HELICOBACTER PYLORI". Helicobacter 18 (2013): 130-130. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000324047300181&KeyUID=WOS:000324047300181.
    Published
  123. Gaspar, Maria Manuela; Radomska, Anna; Gobbo, Oliviero L.; Bakowsky, Udo; Radomski, Marek W.; Ehrhardt, Carsten. "Targeted Delivery of Transferrin-Conjugated Liposomes to an Orthotopic Model of Lung Cancer in Nude Rats". Journal of Aerosol Medicine and Pulmonary Drug Delivery 25 6 (2012): 310-318. http://dx.doi.org/10.1089/jamp.2011.0928.
    Published • 10.1089/jamp.2011.0928
  124. Gaspar, Maria Manuela; Cecília R.C. Calado; António J. Almeida; Lídia M D Gonçalves; Mónica Roxo-Rosa; Figueiredo, L.; Carvalho, T.; et al. "NOVEL VACCINE AGAINST HELICOBACTER PYLORI: THE EFFECT OF THE DELIVERY SYSTEM". NOVEL VACCINE AGAINST HELICOBACTER PYLORI: THE EFFECT OF THE DELIVERY SYSTEM (2011): https://publons.com/publon/7785524/.
    Published
  125. Mulchande, Jalmira; Simões, Sandra I.; Gaspar, Maria M.; Eleutério, Carla V.; Oliveira, Rudi; Cruz, Maria E.M.; Moreira, Rui; Iley, Jim. "Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-ß-lactam inhibitor of human leukocyte elastase". Journal of Enzyme Inhibition and Medicinal Chemistry 26 2 (2010): 169-175. http://dx.doi.org/10.3109/14756366.2010.486794.
    Published • 10.3109/14756366.2010.486794
  126. Gaspar, Maria Manuela; Gobbo, Oliviero; Ehrhardt, Carsten. "Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulizers". Journal of Liposome Research 20 1 (2010): 55-61. http://dx.doi.org/10.3109/08982100903085150.
    Published • 10.3109/08982100903085150
  127. Sitterberg, J.; Gaspar, M.M.; Ehrhardt, C.; Bakowsky, U.. "Atomic force microscopy for the characterization of proteoliposomes.". Methods in molecular biology (Clifton, N.J.) 606 (2010): 351-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649214901&partnerID=MN8TOARS.
  128. Figueiredo, Ricardo; Moiteiro, Cristina; Medeiros, M. Augusta; Silva, P. Almeida da; Ramos, D.; Spies, F.; Ribeiro, M.O.; et al. "Synthesis and evaluation of rifabutin analogs against Mycobacterium avium and H37Rv, MDR and NRP Mycobacterium tuberculosis". Bioorganic & Medicinal Chemistry 17 2 (2009): 503-511. http://dx.doi.org/10.1016/j.bmc.2008.12.006.
    Published • 10.1016/j.bmc.2008.12.006
  129. Gaspar, M.; Cruz, A.; Fraga, A.; Castro, A.; Cruz, M.; Pedrosa, J.. "Developments on Drug Delivery Systems for the Treatment of Mycobacterial Infections". Current Topics in Medicinal Chemistry 8 7 (2008): 579-591. http://dx.doi.org/10.2174/156802608783955629.
    Published • 10.2174/156802608783955629
  130. Gaspar, M.M.; Cruz, A.; Penha, A.F.; Reymão, J.; Sousa, A.C.; Eleutério, C.V.; Domingues, S.A.; et al. "Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis". International Journal of Antimicrobial Agents 31 1 (2008): 37-45. http://dx.doi.org/10.1016/j.ijantimicag.2007.08.008.
    Published • 10.1016/j.ijantimicag.2007.08.008
  131. Gaspar, M.M.; Bakowsky, U.; Ehrhardt, C.. "Inhaled liposomes - Current strategies and future challenges". Journal of Biomedical Nanotechnology 4 3 (2008): 245-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149177361&partnerID=MN8TOARS.
    10.1166/jbn.2008.334
  132. Botelho, M.L.; Cabo Verde, S.; Alves, L.; Belchior, A.; Reymão, J.; Trabulo, S.; Gaspar, M.M.; Cruz, M.E.M; Simões, S.. "Radiation sterilization of antibiotic liposome formulations: A case study". Radiation Physics and Chemistry 76 8-9 (2007): 1542-1546. http://dx.doi.org/10.1016/j.radphyschem.2007.02.069.
    Published • 10.1016/j.radphyschem.2007.02.069
  133. Gaspar, Maria Manuela; Maria Eugénia Meirinhos Cruz; Fatima Ventura; S Violante; C Gomes; Isabel Tavares de Almeida. "The human carnitine acylcarnitine translocase (hCACT): Strategies for its heterologous expression, purification and crystallization". Journal of Inherited Metabolic Disease (2007): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248860000209&KeyUID=WOS:000248860000209.
    Published
  134. Gaspar, M.M.; Boerman, O.C.; Laverman, P.; Corvo, M.L.; Storm, G.; Cruz, M.E.M.. "Enzymosomes with surface-exposed superoxide dismutase: In vivo behaviour and therapeutic activity in a model of adjuvant arthritis". Journal of Controlled Release 117 2 (2007): 186-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846580605&partnerID=MN8TOARS.
    10.1016/j.jconrel.2006.10.018
  135. Cruz, MEM; Gaspar, MM; Silva, MT. "Conventional versus stealth rifabutin liposomes for prophylaxis of M-avium infection". Journal of Liposome Research 13 1 (2003): 57-58. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000181879100033&KeyUID=WOS:000181879100033.
    Published
  136. Gaspar, M.M.; Martins, M.B.; Corvo, M.L.; Cruz, M.E.M.; Gaspar, M.M; Martins, M.B; Corvo, M.L; Cruz, M.E.M. "Design and characterization of enzymosomes with surface-exposed superoxide dismutase". Biochimica et Biophysica Acta - Biomembranes 1609 2 (2003): 211-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037474030&partnerID=MN8TOARS.
    Published • 10.1016/S0005-2736(02)00702-2
  137. Gaspar, M.M.; Neves, S.; Portaels, F.; Pedrosa, J.; Silva, M.T.; Cruz, M.E.M.. "Therapeutic efficacy of liposomal rifabutin in a Mycobacterium avium model of infection". Antimicrobial Agents and Chemotherapy 44 9 (2000): 2424-2430. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033840163&partnerID=MN8TOARS.
    Published • 10.1128/AAC.44.9.2424-2430.2000
  138. Manuela Gaspar, M.; Blanco, D.; Cruz, M.E.M.; José Alonso, M.. "Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: Influence of polymer properties on enzyme loading, activity and in vitro release". Journal of Controlled Release 52 1-2 (1998): 53-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032473386&partnerID=MN8TOARS.
    Published • 10.1016/S0168-3659(97)00196-X
  139. Gaspar, M. M.; Perez-Soler, R.; Cruz, M. E. M.. "Biological characterization of L -asparaginase liposomal formulations". Cancer Chemotherapy and Pharmacology 38 4 (1996): 373-377. http://dx.doi.org/10.1007/s002800050497.
    Published • 10.1007/s002800050497
  140. Alonso, M.J.; Gaspar, M.M.; Blanco, M.D.; Cruz, M.E.M.; Alonso, MJ; Gaspar, MM; Blanco, MD; Cruz, MEM; CONTROLLED RELEASE SOC. "Development of poly(lactic/glycolic acid) nanospheres containing a high loading of L-asparaginase". Proceedings of the Controlled Release Society 23 (1996): 831-832. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029791476&partnerID=MN8TOARS.
    Published
  141. Cruz, M.E.M.; Gaspar, M.M.; Mimoso, I.M.; Portaels, F.; Silva, M.T.. "Liposomal rifamycins: In vivo evaluation". Proceedings of the Controlled Release Society 22 (1995): 462-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029164416&partnerID=MN8TOARS.
    Published
  142. GASPAR, MM; MIMOSO, IM; SILVA, MT; PORTAELS, F; CRUZ, MEM; Crommelin, D; Couvreur, P; Duchene, D. "PRELIMINARY-RESULTS OF A MODEL FOR TESTING MYCOBACTERIUM-AVIUM SUSCEPTIBILITY TO DIFFERENT FORMULATIONS OF RIFAMICINS". In Vitro and Ex Vivo Test Systems To Rationalize Drug Design and Delivery (1994): 289-292. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994BA37V00037&KeyUID=WOS:A1994BA37V00037.
    Published
  143. Cruz, M.E.M.; Martins, M.B.; Corvo, M.L.; Jorge, J.C.S.; Gaspar, M.M.. "Native and lipophilic derivatives of asparaginase and superoxide dismutase and respective liposomal forms". Proceedings of the Controlled Release Society 21 (1994): 346-347. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028091569&partnerID=MN8TOARS.
  144. Cruz, M.E.M.; Gaspar, M.M.; Lopes, F.; Jorge, J.S.; Perez-Soler, R.. "Liposomal l-asparaginase: in vitro evaluation". International Journal of Pharmaceutics 96 1-3 (1993): 67-77. http://dx.doi.org/10.1016/0378-5173(93)90213-y.
    Published • 10.1016/0378-5173(93)90213-y
Journal issue
  1. Matias, Mariana; Gaspar, Maria Manuela. "Special Issue: Applications of Nanotechnology for Melanoma Treatment and Diagnosis". Pharmaceutics (2022):
Thesis / Dissertation
  1. Gaspar, Maria Manuela. "Liposomal Formulations of rifabutin and acylated superoxide Dismutase". PhD, Universidade de Lisboa Faculdade de Farmácia, 2005.

Intellectual property

Patent
  1. Gaspar MM; Gaspar, Maria Manuela. 2013. "Design of a nose-only-chamber, for several animals simultaneously, promoting the targeted pulmonary administration of dry powder formulations". Portugal.
  2. Gaspar, Maria. 2004. "Derivados N- substituidos de rifabutina úteis como agentes antimicrobianos, processo para a sua preparação e sua utilização como medicamentos"". Portugal.
  3. Gaspar, Maria. 1998. "Processo para Preparação de Proteínas Lipossomais com Elevado Índice Terapêutico, nomeadamente a L-Asparaginase". Portugal.
  4. Gaspar, Maria. 1993. "Formulações Lipossomais de Rifamicinas com Elevada Estabilidade e Eficácia de Incorporação de Antibiótico e Processo para a sua Preparação". Portugal.

Other

Other output
  1. Oxidovanadium(IV) complexes containing 8-hydroxyquinoline Schiff bases – synthesis, characterization and biological screening. Oral Communication at the XVth Spanish-Portuguese Conference on Controlled Drug Delivery (Lisbon, Portugal). 2024. Côrte-Real, Leonor; A. Alborghetti; Neto, Íris; Mariana Coelho; Joana Lopes; Gaspar, Maria Manuela; Catarina P. Reis; et al.
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/11/01 - Current Nanoplatforms of metal-based complexes for the treatment of melanoma
Supervisor
Farmácia, Tecnologia Farmacêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/11/01 - 2028/12/31 Lipid-based nanosystems combining cytotoxic and magnetic properties as a tool to improve the antitumor activity of 5-flourouracil towards colorectal cancer
Supervisor
Farmácia, Tecnologia Farmacêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/10/01 - 2028/09/30 Advanced Therapeutic Breakthroughs for Triple-Negative Breast Cancer: Precision Targeting of an Aggressive Subtype with Next-Generation Photothermal Enhancers
Co-supervisor
Farmácia, Tecnologia Farmacêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/01 - 2027/12 Integrated approach on the treatment of colorectal cancer with nanostructured delivery systems
Supervisor
2023 - 2027 Development of different nanoapproaches for colorectal cancer: How far can it really help the targetability of metallodrugs?”.
Co-supervisor
2022/01/01 - 2026/12/31 Searching Innovative Therapeutic Nanoplatforms with Metal-based Complexes Against Pancreatic Cancer
Co-supervisor
Farmácia, Tecnologia Farmacêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/02/01 - 2026/01/31 Upconversion nanoparticles for multimodal therapy of melanoma
Co-supervisor
Biologia (PhD)
Universidade de Aveiro, Portugal
2022/01/02 - 2025/12/31 Development of different nanoapproaches for colorectal cancer: How far can it really help the targetability of metallodrugs?
Co-supervisor of Íris Raquel Branco Neto
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/12/01 - 2025/12/01 Nanoplatforms of metal-based complexes for the treatment of melanoma
Supervisor of Pedro Daniel Franco Farinha
2020/02/01 - 2024/11/30 Targeting superficial tumors using a nanotechnological hybrid approach
Co-supervisor
Farmácia, Tecnologia Farmacêutica (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/05 - 2024/07/30 Dual antibiotic-lipid based nanosystem as a tool to specically target staphylococcus aureus biofilms
Co-supervisor of Magda Sofia Catroga Ferreira
Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2024/02 Targeting superficial tumors using a nanotechnological hybrid approach
Co-supervisor
2021/09 - 2024/01 Rifabutin Liposomes: a novel nanotechnological strategy for effective treatment of systemic methicilin-resistant staphylococus aureus infections
Supervisor
Post-Doc (Other)
2020 - 2024 Upconversion nanoparticles for multimodal therapy of melanoma
Co-supervisor
Universidade de Aveiro, Portugal
2023/01/02 - 2023/12 Validation of a novel hybrid nanosystem integrating cytotoxic and magnetic properties as a tool to potentiate antitumor activity
Supervisor
Ciências de Engenharia de Micro e Nanotecnologias de Processos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/01 - 2023/12 Design of a hybrid lipid nanosystem combining cytotoxic and magnetic properties
Supervisor
Mestrado em Engenharia Biomédica e Biofísica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/04 - 2023/08 In vitro and in vivo validation of a new gold complex with potential towards melanoma
Supervisor
Erasmus Student (Other)
Uniwersytet Jagiellonski w Krakowie Collegium Medicum, Poland
2020/07/01 - 2022/01/30 Nanoformulations of novel metal complexes as potential antitumor agents: in vitro and in vivo studies
Supervisor of Melissa Daniela Albino Teixeira.
Master Biomedical Research (Oncobiology) Faculdade de Ciências Médicas, NOVA Medical School of NOVA University Lisbon (Master)
2020/09 - 2021/12 Improved selectivity and in vitro cytotoxic effects of hybrid molecules via liposomal delivery as a tool to fight melanoma
Supervisor of Maria João Penetra
Master in Biopharmaceutical Sciences. FFUL. University of Lisbon (Master)
2019/04/01 - 2021/09/30 Compostos híbridos nanoformulados para o direccionamento específico de melanoma metastático
Supervisor
Post-Doc (Other)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/05 - 2021/09/16 Cancer chemotherapeutic agents using a nanotechnological approach
Supervisor of Jacinta Oliveira Pinho
Pharmaceutical Technology (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01 - 2021/09 Magnetic Nanoparticles in Diagnostics: A Review of Recent Advances
Supervisor
Mestrado Integrado (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/10 - 2020/10 Biomedical Applications of Fluorinated Ionic Liquids as Drug Delivery Systems
Co-supervisor
Ciências Biofarmacêuticas (Master)
Universidade Nova de Lisboa Departamento de Química, Portugal
2019/08 - 2020/08 Non-invasive elimination of superficial tumours: a step forward
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/02 - 2017/02 Diagnóstico serológico da peripneumonia contagiosa dos bovinos – uma abordagem nanotecnológica
Co-supervisor of Nicole Marie Dinis-Tonelo
Mestrado em Medicina Veterinária (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2015/02/01 - 2015/09/30 Fluticasone propionate loaded in liposomes: in vitro and in vivo evaluation
Supervisor of Yattussia Ambinintsoa Mafilaza
Master in Sciences du Medicament, Développement analytique et biopharmaceutiques, (Master)
Université Claude Bernard Lyon 1 Institut des Sciences Pharmaceutiques et Biologiques Faculté de Pharmacie de Lyon, France
2015/02/01 - 2015/09/30 In vitro and in vivo profile of cyclodextrin formulations for the treatment of lung diseases
Supervisor of Marina Dogbe
Master in Sciences du Medicament, Développement analytique et biopharmaceutiques (Master)
Université Claude Bernard Lyon 1 Institut des Sciences Pharmaceutiques et Biologiques Faculté de Pharmacie de Lyon, France
2013 - 2013 Nanoformulations of a potent aquaporin-3 inhibitor with cytotoxic effect against cancer cell lines
Co-supervisor of Mariana Vieira de Almeida Nave
Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/02 - 2012/11 Development of nanoformulations of pyrazinoic acid prodrugs for treatment of Mycobacterium avium,
Co-supervisor of Mariana Matoso
Mestrado em Microbiologia Aplicada (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2012/01 - 2012/10 Nanossistemas lipídicos para a veiculação de moléculas com actividade leishmanicida
Supervisor
Mestrado Integrado (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/01 - 2012/10 Nanoformulations of triazene analogues with specific affinity to human melanoma
Supervisor of Susana Calado
Mestrado em Biologia Molecular em Saúde (Master)
Escola Superior de Saúde Egas Moniz, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018/01/03 - Current Curso Prático de Experimentação Animal SPCAL - FFUL , Categoria B de Ciências em Animais de Laboratório. Curso a decorrer anualmente desde 2018 (2018/01/03)
Other (Co-organisor)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 First Symposium on Advanced Technologies for Drug Delivery (2021/10/21 - 2021/10/22)
Symposium (Co-organisor)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2016/01 - 2018/01 Board Member of the Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) (2016/01 - 2018/01)
Conference (Co-organisor)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/10/13 - 2021/10/13  Therapeutic strategies for melanoma treatment
Seminar
Novel Advanced Nanomaterials for Biological Applications
Universidade de Aveiro, Portugal
2021/04/19 - 2021/04/19 Moléculas com interesse farmacológico: da descoberta à avaliação biológica
Seminar
Plantas Medicinais e Produtos Naturais em Parasitologia
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2022/12 Potential of Ionic Liquids as Protein Drug Delivery Systems
(Thesis) Arguer
Márcia Maria da Silva Alves (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/12 Peroxiporins Involvement in Oxidative Stress and their Potential for Drug Targeting
(Thesis) Main arguer
Joana Pinheiro Pimenta (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/07 Preparação e Caracterização de Decocções de Algas Marinhas Comestíveis Encapsuladas em Nanopartículas para a Redução do Risco de Doenças Cardiovasculares
(Thesis) Main arguer
Sofia Isabel Brites Pinto (Master)
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2021/12 NUEVA PLATAFORMA DE ADMINISTRACIÓN PULMONAR BASADA EN REDES METAL-ORGÁNICAS CON POTENCIAL APLICACIÓN EN EL TRATAMIENTO DE LA TUBERCULOSIS, PhD thesis
Thesis Member
Cristina Fernandez-Paz: (PhD)
Universidade de Santiago de Compostela, Spain
2021/09/16 Cancer chemotherapeutic agents using a nanotechnological approach, PhD Thesis (supervisor)
Supervisor
Jacinta de Oliveira Pinho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/14 Skin Delivery Of Bioactive Plant Extracts Through Nanocarriers, PhD Thesis (Arguer)
(Thesis) Arguer
Ana Luísa Vargas Henriques Mota (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11 PAMAM and PPI dendrimers as delivery systems of rose bengal to treat basal cell carcinoma: a photodynamic therapy preliminary approach
(Thesis) Main arguer
Ana Sofia Dias Martins (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11 Ferrous Oxide Nanoparticles as liposome targeting adjuvants in mouse model melanoma chemotherapy, Master thesis, (main arguer)
(Thesis) Main arguer
Nuno Guilherme Valadas da Cruz (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/11 Estudo das atividades biológicas da alga Undaria pinnatifida
(Thesis) Main arguer
Bernardo Faria Gonçalves Pimenta Pedro (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09 Fracionamento e identificação de compostos de extratos de plantas medicinais da Guiné-Bissau com atividade biológica - Master thesis (main arguer)
(Thesis) Main arguer
Cláudia Heitor de Matos Chambel Valente (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/03/06 Gestão De Resíduos Hospitalares - Estudo de referenciais de boas práticas, com base na perceção e na avaliação do risco de exposição ocupacional num Hospital Central, PhD thesis
(Thesis) Main arguer
Beatriz da Graça Nunes Veiga Edra (PhD)
Universidad de Alcalá de Henares, Spain
2019/03/06 Innovative nanotechnology formulations for the treatment of yeast infections in oral mucosa, PhD thesis
(Thesis) Arguer
Luis Miguel Vasques Roque (PhD)
Universidad de Alcalá de Henares, Spain
2019/02/02 TRANSPORTADORES NANO E MICROPARTICULADOS DIRECIONADOS PARA OS MACRÓFAGOS ALVEOLARES, NO TRATAMENTO DA TUBERCULOSE. PhD thesis (main arguer)
(Thesis) Main arguer
LUDMYLLA COSTA CUNHA (PhD)
Universidade do Algarve, Portugal
2019/02 Nano and microparticles as carriers for alveolar macrophage targeting in pulmonary tuberculosis therapy
(Thesis) Main arguer
Ludmylla Costa Cunha (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018/12/05 Development of novel therapeutic approaches to promote the healing of chronic wounds. PhD thesis (main arguer)
(Thesis) Main arguer
Itxaso García Orue (PhD)
Universidad del País Vasco Biblioteca Campus de Álava, Spain
2018 Evaluation of aquaporins in cancer as potential biomarkers or drug targets, Master thesis (main arguer)
(Thesis) Main arguer
António João de Almeida Lemos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/11/20 Desenvolvimento de bionanoconjugados para a deteção de anticorpos anti-Pneumocystis jirovecii , Master thesis (main arguer)
(Thesis) Main arguer
Mafalda Barroso Capela Dias Pinto (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/11/12 Development of a theranostic system for central nervous system based on superparamagnetic nanoparticles, Master thesis (Main arguer)
(Thesis) Main arguer
Mariana Filipa Mestre Pina Amaro (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/10/06 Pharmaco - and immunotherapeutic strategies for the topical treatment of cutaneous leishmaniasis, PhD thesis (main arguer)
(Thesis) Main arguer
Juana Schwartz Mota (PhD)
Universidad de Navarra, Spain
2016/02 Aplicação de anticorpos recombinantes para o diagnóstico da pneumocistose. Master thesis (main arguer)
(Thesis) Main arguer
Marta Maria Ramos Soares Ribeiro (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/11 Desenvolvimento de um teste de diagnóstico serológico rápido para a deteção de Pneumocystis jirovecii em amostras clínicas
(Thesis) Main arguer
Mariana de Carvalho Ribeiro Coutinho (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015/11 Microencapsulation of antitubercular drugs in a matrix of partially hydrolyzed guar gum, for application in tuberculosis treatment. Master thesis (main arguer).
(Thesis) Main arguer
Tatiana dos Reis Martins (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/12 Bioensaio de extratos vegetais em Biomphalaria glabrata exposta a Schistosoma mansoni
(Thesis) Main arguer
Hélder Felício Fernandes (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/11 Novas abordagens no diagnóstico serológico da pneumocistose
(Thesis) Main arguer
Ana Luísa Regatão Tomás (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014 Novas abordagens no diagnóstico serológico da pneumocistose Ana Luisa Regatão Tomás Chocalheiro (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014 Bioensaio de extratos vegetais em Biomphalaria glabrata exposta a Schistosoma mansoni Hélder Felício Fernandes (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014 Hybrid lipid-polymeric nanoplatform as cancer immunotherapeutics , PhD Thesis (arguer)
(Thesis) Arguer
Vanessa Gameiro Sainz (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 Microencapsulated lipid nanoparticles for pulmonary delivery of biopharmaceutical agents, PhD thesis (arguer)
(Thesis) Arguer
Diana Patrícia Rodrigues Gaspar (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/11 Nanomedicamentos para el tratamiento localizado de patologias pulmonares
(Thesis) Arguer
Felipe Andrés Oyarzún Ampuero (PhD)
Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Spain

Association member

Society Organization name Role
2019/10 - Current Member of the COST-Action , CA17140, Nano2Clinic Cancer Nanomedicine - from the bench to the bedside Action Member
2017 - Current Sociedade Portuguesa de Ciências em Animais de Laboratório Membro da sociedade
2014 - Current Rede Nacional de Órgãos Responsáveis pelo Bem estar dos Animais desde 2014 Membro
2011 - Current Animal facilities of the Faculty of Pharmacy , Universidade de Lisboa - management responsible
2003 - Current Sociedade Portuguesa de Ciências Farmacêuticas Membro
1995/09 - Current Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) Membro da sociedade
2019 - 2021 Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL) Secretária da Assembleia Geral Secretária da Assembleia Geral

Committee member

Activity description
Role
Institution / Organization
2016 - Current Animal Welfare Organ, Faculty of Pharmacy, University of Lisbon, Portugal
Member
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/01 - Current Responsible for the welfare and management of the animal facilities of the Faculty of Pharmacy, Universidade de Lisboa since january 2009.
Coordinator
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Presidente da Assembleia Geral da Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL)
President / Vice-president
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2011 - 2016 Membro da Comissão de Ética para Experimentação Animal da Faculdade de Farmácia da Universidade de Lisboa (2011 - 2016)
Member
Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/04/21 - 2025/04/21 Aplicações de nanomedicamentos em doenças infecciosas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/02 - 2021/12/06 Curso Prático de Experimentação Animal SPCAL - FFUL , Categoria B de Ciências em Animais de Laboratório (4ª edição) (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/02 - 2021/04/27 Curso Prático de Experimentação Animal SPCAL - FFUL, Categoria B de Ciências em Animais de Laboratório (3ª edição) (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/02 - 2019/09/30 Curso de Experimentação Animal SPCAL - FFUL, Categoria B de Ciências em Animais de Laboratório (2ª edição) (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/03 - 2018/09/30 Curso de Experimentação Animal SPCAL - FFUL, Categoria B de Ciências em Animais de Laboratório (1ª edição) (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2021 Bolsa de Inovação - Validation of a new nanotechnological approach for the treatment of melanoma metastasis using primary cells from IPO patients
Ordem dos Farmaceuticos, Portugal
2020 Melhor Comunicação Oral SPP/Medinfar, "TERAPÊUTICA INALÁVEL DA TUBERCULOSE: UM ALINHAMENTO DA VIA DE ADMINISTRAÇÃO DO FÁRMACO COM A VIA DE INFEÇÃO "
Sociedade Portuguesa de Pneumologia, Portugal
2020 Melhor Comunicação Oral:"A Novel Nanoformulated Hybrid Molecule as a Promising Strategy for the Treatment of Melanoma”
Ordem dos Farmaceuticos, Portugal
2020 The World’s Top 2% Scientists 2021
Stanford University, United States
2019 Oral Communication, Liposomes as drug delivery systems for the treatment of infectious diseases
Phospholipid Forschungszentrum e V, Germany

Other distinction

2022 The World’s Top 2% Scientists 2023
Stanford University, United States
2021 The World’s Top 2% Scientists 2022
Stanford University, United States
1996 Graduate Student Award in Pharmacy and Pharmaceutical Sciences
The Nagai Foundation, Japan