Maria Manuela de Jesus Guilherme Gaspar is a Researcher at the Faculty of Pharmacy, Universidade de Lisboa, member of the Research Institute for Medicines, iMed.ULisboa since January 2009 and, collaborator at Instituto de Biofísica e Engenharia Biomédica (IBEB), Faculty of Sciences, Universidade de Lisboa since december 2023. She completed the graduation in Engenharia Química Industrial in 1991, at Instituto Superior de Engenharia de Lisboa. She obtained her PhD degree in 2005 in Pharmacy, Pharmaceutical Technology, Universidade de Lisboa with the thesis entitled "Liposomal formulations of Rifabutin and Acylated Superoxide Dismutase". Between october 2007 - october 2008 she was a post-doc at School of Pharmacy and Pharmaceutical Sciences, Trinity College, University Dublin, Ireland. In the last decades, the research has been focused on design, development and biological evaluation of drug delivery systems for improving the therapeutic index of incorporated molecules for the treatment of infectious, inflammatory and cancer diseases. Design, characterization and stability evaluation of appropriated delivery systems, of lipid polymeric and metallic nature for drug delivery and targeting using different routes of administration namely pulmonary, intranasal, dermal, parenteral and oral. In vitro and in vivo evaluation of low and high molecular weight molecules such as antibiotics (rifabutin, paramomycin), enzymes (L-Asparaginase, Superoxide Dismutase). In vitro screening, of new synthesized molecules including metal-based complexes with potential antitumor activity, using 2D and 3D models. Establishment of appropriate infectious and cancer murine models, such as M. avium, M. tuberculosis, leishmania, MRSA, melanoma, breast and colon cancer, for evaluating the therapeutic effect of developed nanoformulations. She has participated in more than 30 research projects as team member or as PI. She has been supervising Post-doc, PhD, master and undergraduate students (> 85) . She is co-author of more than 117 articles in journals (Indexed Scopus), book chapters (9) and patents (h-index 34). She is responsible for the animal facilities (since 2009) and member of the welfare organ of the Faculty of Pharmacy since 2011. In addition, she also belongs to governing bodies of the Portuguese Society for Laboratory Animal Science.