Nísia Borralho Martins (4718-EBD3-7B6C)

Curriculum Vitae

Nísia Martins is enrolled in PhD Degree in Biomedical Sciences at Algarve Biomedical Center Research Institute (ABC-RI), granted by Fundação para a Ciência e Tecnologia (FCT). The PhD project relies on how the temporal control of cell differentiation is achieved, specifically at the level of epigenome dynamics during early stages of development. Nísia concluded a Master's Degree in Molecular Genetics and Biomedicine in January 2022 at NOVA School of Science and Technology - FCT NOVA, where she previously obtained a Bachelor's degree in Cell and Molecular Biology in June 2019. She also concluded a Post-Graduate Course on Laboratory Animal Science in 2021/09/24 by Faculty of Pharmacy, University of Lisbon. She has great command over a highly diverse range of laboratory equipment and techniques (namely electroporation, in situ hybridization, RT-qPCR, immunohistochemistry, maintenance of tissue and organs from cellular and animal models and protein/DNA/RNA quantification in tissue). She also has knowledge of standard Bioinformatic tools and analysis of experimental data. Nísia also has concluded of the 5th grade of Guitar, Orquestra and Musical Education. Works in the area of Natural Sciences with emphasis on Biological Sciences. Her research fields of interest include Developmental Biology and Regenerative Medicine.

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Identification

Personal identification

Full name: Nísia Borralho Martins
Date of birth: 1998/09/09
Gender: Female

Citation names

Borralho-Martins, Nísia

Author identifiers

Ciência ID: 4718-EBD3-7B6C
ORCID iD: 0000-0001-5713-3240

Email addresses

nisiabmartins@gmail.com (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Developmental Biology

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Advanced (C1)	Proficiency (C2)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2023/01/01 - 2027/01/01 Ongoing	Biomedical Sciences (Doutoramento) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019/09/12 - 2022/01/20 Concluded	Genética Molecular e Biomedicina (Mestrado) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Dissertation Title: "Testing miRNA-cell based strategies to obtain therapeutic secretomes for spinal Amyotrophic Lateral Sclerosis". Nota: 19/20. PTDC/MED-NEU/31395/2017 and LISBOA-01-0145-FEDER-031395" (THESIS/DISSERTATION)	18
2021/09/21 - 2021/09/25 Concluded	SPCAL (Sociedade Portuguesa de Ciências em Animais de Laboratório) de Categoria B de Ciências em Animais de Laboratório - Prático (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal	18
2021/07/10 - 2021/07/14 Concluded	SPCAL (Sociedade Portuguesa de Ciências em Animais de Laboratório) de Categoria B de Ciências em Animais de Laboratório - Teórico (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal	18
2016/09 - 2019/06 Concluded	Biologia Celular e Molecular (Licenciatura) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Optimization of the analysis method by HRM (high resolution melting) for genotyping strains of Brucella melitensis, B. abortus and B. suis" (THESIS/DISSERTATION)	16

Affiliation

Science

	Category Host institution	Employer
2023/01/01 - Current	Researcher (Research)	Algarve Biomedical Center Research Institute, Portugal

2020/09 - 2021/11	Research Trainee (Research)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019/02 - 2019/04	Research Trainee (Research)	Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Others

	Category Host institution	Employer
2022/01/31 - 2022/02/28	Diagnostic Technician for COVID-19 - Nasopharyngeal Exudate Collection and Rapid Antigen Tests	Farmácia Carvalho, Portugal

2018/07/01 - 2018/07/30	Internship at the Laboratory of Pathological Anatomy	Grupo HPA Saúde, Portugal

Projects

Grant

	Designation	Funders
2023/01/01 - Current	Embryo Clock-Dependent Epigenome Dynamics in Temporal Control of Cell Differentiation 2022.12867.BD PhD Student Fellow Algarve Biomedical Center Research Institute, Portugal Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Contract

	Designation	Funders
2020/09 - 2021/10	Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis ALS PTDC/MED-NEU/31395/2017 LISBOA-01-0145- FEDER-031395 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference poster

Matos, Ana Teresa; Borralho-Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita. Corresponding author: Matos, Ana Teresa. "miRNA Engineering of Pathological Microglia as a Promising Therapeutic Strategy for Amyotrophic Lateral Sclerosis". Paper presented in Federation of European Neuroscience Societies (FENS) Regional Meeting, 2023.
Matos, Ana Teresa; Loch-Neckel, Gecioni; Borralho-Martins, Nísia; Vaz, Ana Rita; Brites, Dora. Corresponding author: Matos, Ana Teresa. "Inhibiting miR-125b Overexpression in Amyotrophic Lateral Sclerosis Spinal Microglia Restores their Homeostatic Profile". Paper presented in VI Symposium of the Portuguese Glial Network, 2022.
Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Inhibiting miR-125b overexpression in ALS spinal microglia restores their homeostatic profile". Paper presented in VI Symposium of the Portuguese Glia Network, 2022.
Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "miR-125b inhibitor recovers microglial homeostatic profile conveying neuroprotection in ALS". Paper presented in iMed.ULisboa Meeting 2022, 2022.
Vaz, Ana Rita; Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Barbosa, Marta; Brites, Dora. "Regeneration of Microglia Homeostasis and Paracrine Signaling in Models of Spinal ALS Disease". Paper presented in Symposium SPN - Molecular mechanisms of neurodegeneration -thinking outside the box. Congresso Sociedade Portuguesa de Neurociências, 2021.
Martins, Nísia; Matos, Ana Teresa; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Testing the Benefits of the miRNA-Reshaped Secretome from Motor Neurons in Spinal 3D Cultures Using ALS Models". Paper presented in IMed.ULisboa Meeting 2021, 2021.
Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Studying the Benefits of the Regulation of Inflammatory-miRNAs in Rescuing Microglia Function in ALS". Paper presented in IMed.ULisboa Meeting 2021, 2021.

Journal article

Maia-Fernandes, Ana; Martins-Jesus, Ana; Borralho-Martins, Nísia; Pais de Azevedo, Tomás Augusto Barreiros ; Magno, Ramiro; Duarte, Isabel; Raquel P. Andrade. Corresponding author: Raquel P. Andrade. "SPATIO-TEMPORAL DYNAMICS OF EARLY SOMITE SEGMENTATION IN THE CHICKEN EMBRYO". PlosOne (2024):
10.1371/journal.pone.0297853

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/01/26	Manipulating The Clock: Functional Relevance Of Molecular Clock Oscillations In Early Embryo Development	IX Clinical Biochemistry Workshop Portuguese Society of Biochemistry (Faro, Portugal)
2024/01/25	Embryo Clock-Dependent Epigenome Dynamics in Temporal Control of Cell Differentiation	ABC-RI Pizza-Club Seminar Algarve Biomedical Center Research Institute (Portugal)
2023/02/24	Embryo Clock-Dependent Epigenome Dynamics in Temporal Control of Cell Differentiation	DevoStem Meetings Algarve Biomedical Center Research Institute (Portugal)
2022/03/31	Testing miRNA-Cell Based Strategies To Obtain Therapeutic Secretomes For Spinal ALS	ABC-RI Pizza-Club Seminar Algarve Biomedical Center Research Institute (Faro)
2021/02	Testing the Benefits of the miRNA-Reshaped Secretome from Motor Neurons in Spinal 3D Cultures Using ALS Models	Jornadas Intercalares das Dissertações Anuais dos Mestrados do Departamento de Química e Departamento de Ciências da Vida Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia (Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/05 - 2023/07	Avaliação Funcional do Relógio Molecular no Desenvolvimento Embrionário Co-supervisor of Maria Assunção Cordeiro Piloto	Algarve Biomedical Center Research Institute, Portugal Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/01 - Current	DevoStem Meetings: Internal ABC-RI Meetings with the goal of helping all members to discuss their projects and eventual problems/obstacles that we are currently dealing with, as these interactions contribute to the collaborative and supportive environment we aim to foster. (2023/01) Meeting (Member of the Organising Committee)	Algarve Biomedical Center Research Institute, Portugal
2018/04/11 - 2018/04/11	EXPO FCT NOVA - Dia Aberto da FCT NOVA: With the motto "see to choose", the initiative is a showcase of activities in science and engineering, therefore being an excellent opportunity to help in choosing areas for the continuation of studies by secondary school students and have a close contact with the university environment of one of the most prestigious Science and Engineering Universities in the country. (2018/04/11 - 2018/04/11)	Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/02/07 - 2018/02/08	JORTEC - Jornadas Tecnológicas da Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa: The initiative aims to provide contact between future engineers/scientists/professionals from different areas and also intends to promote the sharing of knowledge and experiences and to create awareness of the potential of each course. (2018/02/07 - 2018/02/08)	Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/01/26 - 2024/01/26	IX Clinical Biochemistry Workshop Workshop	IX Clinical Biochemistry Workshop Sociedade Portuguesa de Bioquímica, Portugal
2023/11/10 - 2023/11/10	Development in Action (DiA Meeting) - Inspiring Embryonic Minds Meeting	Development in Action (DiA Meeting) - Inspiring Embryonic Minds Sociedade Portuguesa de Biologia do Desenvolvimento, Portugal
2023/07/18 - 2023/07/21	EMBO \| EMBL Symposium: Theory and concepts in biology Symposium	EMBL Heidelberg Genome Biology, Germany
2023/03/09 - 2023/03/09	ChIP Analysis and Chromatin Bioinformatics Workshop	Diagenode sa BELGIUM EUROPE, Belgium
2023/03/07 - 2023/03/09	Avian Research Symposium Symposium	Avian Research Symposium 2023 The University of Edinburgh The Roslin Institute, United Kingdom The University of Edinburgh Royal Dick School of Veterinary Studies, United Kingdom
2023/03/08 - 2023/03/08	Tagmentation-Based Methods Workshop	Diagenode sa BELGIUM EUROPE, Belgium
2023/03/06 - 2023/03/06	Chromatin Immunoprecipitation (ChIP) Workshop	Diagenode sa BELGIUM EUROPE, Belgium
2022/12/06 - 2022/12/07	International Conference Ageing With]Out[ Borders Conference	Algarve Biomedical Center Research Institute, Portugal
2022/10/16 - 2022/10/20	19th International Congress of Developmental Biology Congress	International Society of Developmental Biologists, United States Sociedade Portuguesa de Biologia do Desenvolvimento, Portugal
2021/02 - 2021/05	iMed.ULisboa seminars for a Healthy Science: - Neuro-immune interactions: A holistic paradigm in CNS pathology and regeneration - Dr Dora Brites (26/2); - How to Adapt to a Rapidly Changing Publication Landscape - Dr Ruben Ragg (12/3); - Advanced Cell Culture Models: The use of 3D cultures in in vitro toxicology and regenerative medicine - Dr Joana Miranda - (26/3); - Turning molecules into medicines, lessons for liver disease biology - Dr Cecilia Rodrigues (14/5) Seminar	iMed.ULisboa Seminars Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2021/04/13 - 2021/04/13	O Futuro da Medicina e Temas Centrais de Vida: Envelhecimento, Estilos de Vida, Ética - organized by Fundação Amélia de Mello in partnership with the Universidade NOVA de Lisboa and NOVA Medical School Conference	O Futuro da Medicina e Temas Centrais de Vida: Envelhecimento, Estilos de Vida, Ética
2019/10/31 - 2019/10/31	Champalimaud Cancer Talks - "Serendipities of Acquired Immunity" - Dr. Tasuku Honjo Conference	Serendipities of Acquired Immunity Centro Champalimaud, Portugal

Association member

	Society Organization name	Role
2019 - Current	Volunteer at Associação Protagonist Falcon	Demonstration, Treatment and Preservation of Endangered Species, namely birds of prey and reptiles
2017 - 2019	Núcleo de Biologia Celular e Molecular (NBCM)	Organization and dynamization of science outreach events (Conferences, Meetings, Workshops) related to the field of Life Sciences with a focus on Cell and Molecular Biology fostering the knowledge of biology to specialized audiences and the general society

Committee member

	Activity description Role	Institution / Organization
2022/02 - Current	Invited National Ambassador of iMed Conference 14.0: iMed Conference is a project by Nova Medical School's Students' Union, that is held in Lisbon since 2009, addressed to the next generation of Life Science's students. The National Ambassadors Programme was created with the goal of reaching a greater number of Educational Institutions and being closer to the national students who want to participate in the conference, aiming to spread information by the faculties of the health science field in a more intimate manner. Member	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/10/18 - 2023/10/22	Invited National Ambassador of iMed Conference 15.0: iMed Conference is a project by Nova Medical School's Students' Union, that is held in Lisbon since 2009, addressed to the next generation of Life Science's students. The National Ambassadors Programme was created with the goal of reaching a greater number of Educational Institutions and being closer to the national students who want to participate in the conference, aiming to spread information by the faculties of the health science field in a more intimate manner. Member	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023/09/26 - 2023/10/26	Developmental Biology 14th Course – From Stem cells to Morphogenesis		Sorbonne Université - Campus Pierre et Marie Curie, France Institut Curie, France
2022/09/01 - 2022/09/05	Hands-On Molecular Tools Workshop - Fundamental Principles and Standard Techniques used in Molecular Biology		Centro Champalimaud, Portugal

Mentoring / Tutoring

	Topic	Student name
2023/03 - 2023/04	ESTUDO DO RELÓGIO EMBRIONÁRIO NO DESENVOLVIMENTO DO MEMBRO DO EMBRIÃO DE GALINHA	Maria Inês Águas Rodrigues Pinheiro

Distinctions

Award

2022	Best National Ambassador of iMed Conference 14.0
2016	Honor Board Diploma Escola Secundária Poeta António Aleixo, Portugal
2015	Honor Board Diploma Escola Secundária Poeta António Aleixo, Portugal