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Raghu received his Ph.D. in Biochemistry and Molecular Biology from the University of Kansas Medical Center and his M.D. degree from Brown University Medical School. Kalluri was a Post-doctoral fellow and a research associate at the University of Pennsylvania Medical School and studied immunology and mechanisms associated with tissue injury and repair employing organ fibrosis as model system. In 1997, he moved to Harvard Medical School as an Assistant Professor of Medicine and as a faculty member in the Department of Medicine at the Beth Israel Deaconess Medical Center. In 2006, Dr. Kalluri was appointed the Chief of the Division of Matrix Biology and was promoted to Professor of Medicine at Harvard Medical School. He held faculty appointments in the Department of Biological Chemistry and Molecular Pharmacology, Harvard MIT Division of Health Sciences and Technology, Harvard Stem Cell Institute in the division of ephrology of the Children’s Hospital Boston. Raghu was recruited to the MD Anderson Cancer Center in 2012 as a Professor and Chairman of the Department of Cancer Biology and the Director of the Metastasis Research Center. His aboratory is broadly interested in investigating the functional contribution of cell and tissue microenvironment, and Exosomes in cancer progression and metastasis.
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Identification

Personal identification

Full name
Raghu Kalluri

Citation names

  • Kalluri, Raghu

Author identifiers

Ciência ID
511A-4253-3DEA
ORCID iD
0000-0002-2190-547X

Telephones

Telephone
  • (+1) 7137927780 (Professional)

Addresses

  • 1881 East Road, Unit 1906, 77054, Houston, Texas, United States (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English (Mother tongue)
Education
Degree Classification
2009
Concluded
 Medicine (Doctor)
Major in Medicine
Brown University School of Public Health, United States
1992
Concluded
 Biochemistry and Molecular Biology (Doctor of Philosophy)
Major in Biochemistry and Molecular Biology
The University of Kansas Medical Center Center for Child Health and Development, United States
1988
Concluded
 Genetics and Chemistry (Bachelor)
Major in Genetics and Chemistry
Osmania University Nizam College, India
Affiliation

Science

Category
Host institution 		Employer
2012 - Current Principal Investigator (Research) University of Texas MD Anderson Cancer Center, United States
2010 - Current Researcher (Research) Harvard Medical School, Peabody Society, United States
1993 - 1997 Auxiliary Researcher (Research) University of Pennsylvania Department of Medicine, United States
1992 - 1993 Postdoc (Research) University of Kansas Medical Center, United States

Teaching in Higher Education

Category
Host institution 		Employer
2014 - Current Invited Full Professor (University Teacher) Rice University George R Brown School of Engineering, United States
2014 - Current Invited Full Professor (University Teacher) Baylor College of Medicine, United States
2012 - Current Full Professor (University Teacher) University of Texas MD Anderson Cancer Center Department of Cancer Biology, United States
2006 - 2012 Invited Associate Professor (University Teacher) Harvard University Harvard Stem Cell Institute, United States
2006 - 2012 Full Professor (University Teacher) Beth Israel Deaconess Medical Center, Division of Matrix Biology, United States
2006 - 2012 Full Professor (University Teacher) Harvard Medical School, United States
2005 - 2012 Invited Associate Professor (University Teacher) Harvard-MIT Division of Health Sciences and Technology, United States
2005 - 2012 Invited Associate Professor (University Teacher) Harvard Medical School, Biomedical and Biological Sciences (BBS) Graduate Program, United States
2005 - 2012 Invited Associate Professor (University Teacher) Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology, United States
2003 - 2012 Invited Associate Professor (University Teacher) Children's Hospital, Deparment of Medicine, Division of Nephrology, United States
2000 - 2006 Associate Professor (University Teacher) Harvard Medical School, United States
1997 - 2000 Assistant Professor (University Teacher) Harvard Medical School, United States

Positions / Appointments

Category
Host institution 		Employer
2016 - Current RE Bob Smith Distinguished Chair in Cancer Research University of Texas MD Anderson Cancer Center Department of Cancer Biology, United States
2012 - Current Department Chair University of Texas MD Anderson Cancer Center Department of Cancer Biology, United States
2012 - Current Organic Unit Director University of Texas, MD Anderson Cancer Center, Metastasis Research Center, United States
2012 - Current MD Anderson Representative University of Texas, MD Anderson Cancer Center, MD-PhD Program of UT Health and UT MD Anderson Cancer Center, United States
2012 - Current PhD Program Director University of Texas,Health Science Center, Graduate School of Biomedical Science, Cancer Biology Program, United States
2006 - 2012 Chief Beth Israel Deaconess Medical Center, Division of Matrix Biology, United States
2010 - 2011 Organic Unit Sub-director Harvard Medical School, Scholars in Medicine Program, United States
2009 - 2011 Organic Unit Director Champalimaud Cancer Centre, Portugal
2001 - 2006 Organic Unit Director Beth Israel Deaconess Medical Center, Division of Matrix Biology, United States

Others

Category
Host institution 		Employer
2013 - Current Faculty University of Texas, Health Science Center, Graduate School of Biomedical Science (GSBS), United States
2010 - 2011 Member Harvard Medical School Student Education Core Curriculum Committee, United States
Projects

Grant

Designation Funders
2019/07/01 - 2024/06/30 Rigorous and Reproducible Mutational Analysis of the Urinary Exosomal DNA
CA231465
Principal investigator
NIH/NCI
Ongoing
2018/02/01 - 2022/01/31 Intercepting Pancreatic Cancer in High Risk Cohorts
SU2C AACR DT52-17
Researcher
American Association for Cancer Research
Ongoing
2016/12/27 - 2021/11/30 Exosomes in Cancer Therapy
R01 CA213233
Principal investigator
NIH/NCI
Ongoing
2016/07/01 - 2021/06/30 Training Grant in Cancer Biology
5T32CA186892-03
Principal investigator
NIH/NCI
Ongoing
2016/04/01 - 2021/03/31 Genetics and Biology of Pancreatic Ductal Adenocarcinoma
P01 CA117969
Principal investigator
NIH/NCI
Ongoing
2015 - 2018 Tumor Immunity and Fibroblasts in Pancreas Cancer
RP150231
Principal investigator
Cancer Prevention & Research Institute of Texas (CPRIT)
Concluded
2013 - 2018 NCI Cancer Center Support Grant - Metastasis Research Center
P30 CA16672
Principal investigator
NIH/NCI
Concluded
2011/09/26 - 2016 Stromal Regulation of Bone Metastasis
U54 CA163191-06
Principal investigator
NIH/NCI
Concluded
2011/01/01 - 2016 Targeting Pericytes in Cancer
R01 CA155370
Principal investigator
NIH/NCI
Concluded
2010/09/30 - 2016 Role of Fibroblasts, Myeloid Cells and Matrix in PDAC
U01 CA151925
Principal investigator
NIH/NCI
Concluded
2014 - 2015 Exosomal RNA in Normal and Melanoma
U54 CA163191
Principal investigator
NIH/NCI
Concluded
1999/08/15 - 2015 Assembly of Type IV Collagen in Health and Disease
R01 DK055001-10A1
Principal investigator
National Institutes of Health
Concluded
2009/08/25 - 2014 Epigenetic Modifications in Renal Fibrogenesis
R01 DK081576
Principal investigator
National Institutes of Health
Concluded
2008 - 2012 The Role of Fibroblasts in Cancer
R01 CA125550
Principal investigator
NIH/NCI
Concluded
2005/08/01 - 2009 The Biology and Function of BMP-7 in the Kidney
R01 DK061688
Principal investigator
National Institutes of Health
Concluded
2003/09/15 - 2009 Regulation of Angiogenesis by Tumstatin
R01 DK062987
Principal investigator
National Institutes of Health
Concluded
2005/05/15 - 2008 Matrix Microenvironment and Liver Fibrosis
R01 AA013913
Principal investigator
National Institutes of Health
Concluded
1998/06/01 - 2003 ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
R01 DK051711-04
Principal investigator
National Institutes of Health
Outputs

Publications

Book chapter
  1. Kalluri, Raghu; Duncan, M. "Basement membrane derived inhibitors of angiogenesis". In Angiogenesis: An Integrative Approach From Science to Medicine, 121-217. Springer Science & Business Media, 2008.
    Published
  2. Cooke, Vesselina G.; Kalluri, Raghu. "Chapter 1 Molecular Mechanism of Type IV Collagen–Derived Endogenous Inhibitors of Angiogenesis". In Angiogenesis: In Vivo Systems, Part A, 1-19. Elsevier, 2008.
    10.1016/s0076-6879(08)02801-2
  3. Kalluri, Raghu; Reddy, S. "Alport syndrome". In Benner and Rector Book on Genetic Kidney Diseases, 151-171. Philadelphia, PA, United States: Elsevier, 2007.
    Published
  4. Kalluri, Raghu; Sund, M. "Endogenous inhibitors of angiogenesis". In Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy, 215-231. Germany: Springer-Verlag, 2007.
    Published
  5. Kalluri, Raghu; Zeisberg, M; Soubasakos, MA. "Animal models of renal fibrosis". In Methods in Molecular Medicine, 261-272. 2005.
    Published
  6. Kalluri, Raghu; Folkman, J. "Tumor angiogenesis". In Cancer Medicine. Hamilton, Ontario, Canada: BC Decker, 2002.
    Published
  7. Kalluri, Raghu; Sukhatme, VP. "Matrix associated endogenous inhibitors of angiogenesis.". In Tumor Angiogenesis and Microcirculation, 375-385. New York, United States: Marcel Dekker, 2001.
    Published
  8. Meyers CM; Kalluri, Raghu; Neilson, EG. "Anti-basement membrane antibodies in Goodpasture syndrome.". In Immunologic Renal Diseases, 959-973. New York, United States: Lippincott-Raven, 1997.
    Published
Journal article
  1. LeBleu, Valerie S.; Kalluri, Raghu. "Exosomes as a Multicomponent Biomarker Platform in Cancer". Trends in Cancer (2020): http://dx.doi.org/10.1016/j.trecan.2020.03.007.
    10.1016/j.trecan.2020.03.007
  2. Kalluri, Raghu; LeBleu, Valerie S.. "The biology, function, and biomedical applications of exosomes". Science 367 6478 (2020): eaau6977. http://dx.doi.org/10.1126/science.aau6977.
    10.1126/science.aau6977
  3. Helmink, Beth A.; Reddy, Sangeetha M.; Gao, Jianjun; Zhang, Shaojun; Basar, Rafet; Thakur, Rohit; Yizhak, Keren; et al. "B cells and tertiary lymphoid structures promote immunotherapy response". Nature 577 7791 (2020): 549-555. http://dx.doi.org/10.1038/s41586-019-1922-8.
    10.1038/s41586-019-1922-8
  4. McAndrews, Kathleen M.; Kalluri, Raghu. "Nischarin Regulates Secretion of Exosomes and Cancer Progression". Cancer Research 79 9 (2019): 2099-2101. http://dx.doi.org/10.1158/0008-5472.can-19-0387.
    10.1158/0008-5472.can-19-0387
  5. McAndrews, Kathleen M.; LeBleu, Valerie S.; Kalluri, Raghu. "SIRT1 Regulates Lysosome Function and Exosome Secretion". Developmental Cell 49 3 (2019): 302-303. http://dx.doi.org/10.1016/j.devcel.2019.04.024.
    10.1016/j.devcel.2019.04.024
  6. McAndrews, Kathleen M.; Kalluri, Raghu. "Mechanisms associated with biogenesis of exosomes in cancer". Molecular Cancer 18 1 (2019): http://dx.doi.org/10.1186/s12943-019-0963-9.
    10.1186/s12943-019-0963-9
  7. LeBleu, Valerie S.; Kalluri, Raghu. "Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy". Immunity 50 3 (2019): 547-549. http://dx.doi.org/10.1016/j.immuni.2019.02.019.
    10.1016/j.immuni.2019.02.019
  8. Chen, Yang; Keskin, Doruk; Sugimoto, Hikaru; Kanasaki, Keizo; Phillips, Patricia E.; Bizarro, Lauren; Sharpe, Arlene; LeBleu, Valerie S.; Kalluri, Raghu. "Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis". PLOS Biology 16 12 (2018): e2005907. http://dx.doi.org/10.1371/journal.pbio.2005907.
    10.1371/journal.pbio.2005907
  9. Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; et al. "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles 7 1 (2018): 1535750. http://dx.doi.org/10.1080/20013078.2018.1535750.
    10.1080/20013078.2018.1535750
  10. Parchem, Jacqueline G.; Kanasaki, Keizo; Kanasaki, Megumi; Sugimoto, Hikaru; Xie, Liang; Hamano, Yuki; Lee, Soo Bong; et al. "Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice". Journal of Clinical Investigation 128 11 (2018): 5008-5017. http://dx.doi.org/10.1172/jci99026.
    10.1172/jci99026
  11. Xu, Xingbo; Tan, Xiaoying; Tampe, Björn; Wilhelmi, Tim; Hulshoff, Melanie S.; Saito, Shoji; Moser, Tobias; et al. "High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05766-5.
    10.1038/s41467-018-05766-5
  12. Chen, Yang; LeBleu, Valerie S; Carstens, Julienne L; Sugimoto, Hikaru; Zheng, Xiaofeng; Malasi, Shruti; Saur, Dieter; Kalluri, Raghu. "Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program". EMBO Molecular Medicine 10 10 (2018): http://dx.doi.org/10.15252/emmm.201809085.
    10.15252/emmm.201809085
  13. Eikesdal, Hans Petter; Becker, Lisa M.; Teng, Yingqi; Kizu, Akane; Carstens, Julienne L.; Kanasaki, Keizo; Sugimoto, Hikaru; LeBleu, Valerie S.; Kalluri, Raghu. "BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis". Molecular Cancer Research 16 10 (2018): 1568-1578. http://dx.doi.org/10.1158/1541-7786.mcr-18-0120.
    10.1158/1541-7786.mcr-18-0120
  14. Tampe, Björn; Tampe, Désirée; Nyamsuren, Gunsmaa; Klöpper, Friederike; Rapp, Gregor; Kauffels, Anne; Lorf, Thomas; et al. "Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure". Journal of Clinical Investigation 128 7 (2018): 3053-3070. http://dx.doi.org/10.1172/jci89632.
    10.1172/jci89632
  15. Nowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; Aplin, Alfred C.; Auerbach, Robert; Augustin, Hellmut G.; et al. "Consensus guidelines for the use and interpretation of angiogenesis assays". Angiogenesis 21 3 (2018): 425-532. http://dx.doi.org/10.1007/s10456-018-9613-x.
    10.1007/s10456-018-9613-x
  16. Lovisa, Sara; Kalluri, Raghu. "Fatty Acid Oxidation Regulates the Activation of Endothelial-to-Mesenchymal Transition". Trends in Molecular Medicine 24 5 (2018): 432-434. http://dx.doi.org/10.1016/j.molmed.2018.03.003.
    10.1016/j.molmed.2018.03.003
  17. Mendt, Mayela; Kamerkar, Sushrut; Sugimoto, Hikaru; McAndrews, Kathleen M.; Wu, Chia-Chin; Gagea, Mihai; Yang, Sujuan; et al. "Generation and testing of clinical-grade exosomes for pancreatic cancer". JCI Insight 3 8 (2018): http://dx.doi.org/10.1172/jci.insight.99263.
    10.1172/jci.insight.99263
  18. LeBleu, Valerie S.; Kalluri, Raghu. "A peek into cancer-associated fibroblasts: origins, functions and translational impact". Disease Models & Mechanisms 11 4 (2018): dmm029447. http://dx.doi.org/10.1242/dmm.029447.
    10.1242/dmm.029447
  19. Kurywchak, Paul; Tavormina, Jena; Kalluri, Raghu. "The emerging roles of exosomes in the modulation of immune responses in cancer". Genome Medicine 10 1 (2018): http://dx.doi.org/10.1186/s13073-018-0535-4.
    10.1186/s13073-018-0535-4
  20. Gabrusiewicz, Konrad; Li, Xu; Wei, Jun; Hashimoto, Yuuri; Marisetty, Anantha L.; Ott, Martina; Wang, Fei; et al. "Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes". OncoImmunology 7 4 (2018): e1412909. http://dx.doi.org/10.1080/2162402x.2017.1412909.
    10.1080/2162402x.2017.1412909
  21. Brabletz, Thomas; Kalluri, Raghu; Nieto, M. Angela; Weinberg, Robert A.. "EMT in cancer". Nature Reviews Cancer 18 2 (2018): 128-134. http://dx.doi.org/10.1038/nrc.2017.118.
    10.1038/nrc.2017.118
  22. Brabletz, Thomas; Kalluri, Raghu; Nieto, M. Angela; Weinberg, Robert A.. "EMT in cancer". Nature Reviews Cancer 18 2 (2018): 128-134. http://dx.doi.org/10.1038/nrc.2017.118.
    10.1038/nrc.2017.118
  23. Jiao, Jingjing; González, Álvaro; Stevenson, Heather L; Gagea, Mihai; Sugimoto, Hikaru; Kalluri, Raghu; Beretta, Laura. "Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors". Experimental & Molecular Medicine 50 1 (2018): e422-e422. http://dx.doi.org/10.1038/emm.2017.175.
    10.1038/emm.2017.175
  24. Figueroa, Javier; Phillips, Lynette M.; Shahar, Tal; Hossain, Anwar; Gumin, Joy; Kim, Hoon; Bean, Andrew J.; et al. "Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587". Cancer Research 77 21 (2017): 5808-5819. http://dx.doi.org/10.1158/0008-5472.can-16-2524.
    10.1158/0008-5472.can-16-2524
  25. Pickup, Michael W.; Owens, Philip; Gorska, Agnieszka E.; Chytil, Anna; Ye, Fei; Shi, Chanjuan; Weaver, Valerie M.; et al. "Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells". Cancer Immunology Research 5 9 (2017): 718-729. http://dx.doi.org/10.1158/2326-6066.cir-16-0311.
    10.1158/2326-6066.cir-16-0311
  26. Kamerkar, Sushrut; LeBleu, Valerie S.; Sugimoto, Hikaru; Yang, Sujuan; Ruivo, Carolina F.; Melo, Sonia A.; Lee, J. Jack; Kalluri, Raghu. "Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer". Nature 546 7659 (2017): 498-503. http://dx.doi.org/10.1038/nature22341.
    10.1038/nature22341
  27. Kurywchak, Paul; Kalluri, Raghu. "An evolving function of DNA-containing exosomes in chemotherapy-induced immune response". Cell Research 27 6 (2017): 722-723. http://dx.doi.org/10.1038/cr.2017.74.
    10.1038/cr.2017.74
  28. Carstens, Julienne L.; Correa de Sampaio, Pedro; Yang, Dalu; Barua, Souptik; Wang, Huamin; Rao, Arvind; Allison, James P.; LeBleu, Valerie S.; Kalluri, Raghu. "Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer". Nature Communications 8 1 (2017): http://dx.doi.org/10.1038/ncomms15095.
    10.1038/ncomms15095
  29. Megjhani, Murad; Correa de Sampaio, Pedro; Leigh Carstens, Julienne; Kalluri, Raghu; Roysam, Badrinath. "Morphologically constrained spectral unmixing by dictionary learning for multiplex fluorescence microscopy". Bioinformatics 33 14 (2017): 2182-2190. http://dx.doi.org/10.1093/bioinformatics/btx108.
    10.1093/bioinformatics/btx108
  30. Yang, Sujuan; Che, Sara P. Y.; Kurywchak, Paul; Tavormina, Jena L.; Gansmo, Liv B.; Correa de Sampaio, Pedro; Tachezy, Michael; et al. "Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer". Cancer Biology & Therapy 18 3 (2017): 158-165. http://dx.doi.org/10.1080/15384047.2017.1281499.
    10.1080/15384047.2017.1281499
  31. Tampe, Björn; Steinle, Ulrike; Tampe, Désirée; Carstens, Julienne L.; Korsten, Peter; Zeisberg, Elisabeth M.; Müller, Gerhard A.; Kalluri, Raghu; Zeisberg, Michael. "Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression". Kidney International 91 1 (2017): 157-176. http://dx.doi.org/10.1016/j.kint.2016.07.042.
    10.1016/j.kint.2016.07.042
  32. Lovisa, Sara; Zeisberg, Michael; Kalluri, Raghu. "Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis". Trends in Endocrinology & Metabolism 27 10 (2016): 681-695. http://dx.doi.org/10.1016/j.tem.2016.06.004.
    10.1016/j.tem.2016.06.004
  33. Kalluri, Raghu. "The biology and function of fibroblasts in cancer". Nature Reviews Cancer 16 9 (2016): 582-598. http://dx.doi.org/10.1038/nrc.2016.73.
    10.1038/nrc.2016.73
  34. Laklai, Hanane; Miroshnikova, Yekaterina A; Pickup, Michael W; Collisson, Eric A; Kim, Grace E; Barrett, Alex S; Hill, Ryan C; et al. "Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression". Nature Medicine 22 5 (2016): 497-505. http://dx.doi.org/10.1038/nm.4082.
    10.1038/nm.4082
  35. Kalluri, Raghu. "The biology and function of exosomes in cancer". Journal of Clinical Investigation 126 4 (2016): 1208-1215. http://dx.doi.org/10.1172/jci81135.
    10.1172/jci81135
  36. Kalluri, Raghu; LeBleu, Valerie S.. "Discovery of Double-Stranded Genomic DNA in Circulating Exosomes". Cold Spring Harbor Symposia on Quantitative Biology 81 (2016): 275-280. http://dx.doi.org/10.1101/sqb.2016.81.030932.
    10.1101/sqb.2016.81.030932
  37. Cleland, Timothy P.; Schroeter, Elena R.; Zamdborg, Leonid; Zheng, Wenxia; Lee, Ji Eun; Tran, John C.; Bern, Marshall; et al. "Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis". Journal of Proteome Research 14 12 (2015): 5252-5262. http://dx.doi.org/10.1021/acs.jproteome.5b00675.
    10.1021/acs.jproteome.5b00675
  38. Zheng, Xiaofeng; Carstens, Julienne L.; Kim, Jiha; Scheible, Matthew; Kaye, Judith; Sugimoto, Hikaru; Wu, Chia-Chin; LeBleu, Valerie S.; Kalluri, Raghu. "Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer". Nature 527 7579 (2015): 525-530. http://dx.doi.org/10.1038/nature16064.
    10.1038/nature16064
  39. Lovisa, Sara; LeBleu, Valerie S; Tampe, Björn; Sugimoto, Hikaru; Vadnagara, Komal; Carstens, Julienne L; Wu, Chia-Chin; et al. "Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis". Nature Medicine 21 9 (2015): 998-1009. http://dx.doi.org/10.1038/nm.3902.
    10.1038/nm.3902
  40. Melo, Sonia A.; Luecke, Linda B.; Kahlert, Christoph; Fernandez, Agustin F.; Gammon, Seth T.; Kaye, Judith; LeBleu, Valerie S.; et al. "Glypican-1 identifies cancer exosomes and detects early pancreatic cancer". Nature 523 7559 (2015): 177-182. http://dx.doi.org/10.1038/nature14581.
    10.1038/nature14581
  41. Léveillé, Nicolas; Melo, Carlos A.; Rooijers, Koos; Díaz-Lagares, Angel; Melo, Sonia A.; Korkmaz, Gozde; Lopes, Rui; et al. "Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms7520.
    10.1038/ncomms7520
  42. Zeisberg, Michael; Kalluri, Raghu. "Physiology of the Renal Interstitium". Clinical Journal of the American Society of Nephrology 10 10 (2015): 1831-1840. http://dx.doi.org/10.2215/cjn.00640114.
    10.2215/cjn.00640114
  43. Zhang, J.; Jiao, J.; Cermelli, S.; Muir, K.; Jung, K. H.; Zou, R.; Rashid, A.; et al. "miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells". Cancer Research 75 9 (2015): 1859-1867. http://dx.doi.org/10.1158/0008-5472.can-14-1254.
    10.1158/0008-5472.can-14-1254
  44. Xu, Xingbo; Friehs, Ingeborg; Zhong Hu, Tachi; Melnychenko, Ivan; Tampe, Björn; Alnour, Fouzi; Iascone, Maria; et al. "Endocardial Fibroelastosis Is Caused by Aberrant Endothelial to Mesenchymal Transition". Circulation Research 116 5 (2015): 857-866. http://dx.doi.org/10.1161/circresaha.116.305629.
    10.1161/circresaha.116.305629
  45. Keskin, Doruk; Kim, Jiha; Cooke, Vesselina G.; Wu, Chia-Chin; Sugimoto, Hikaru; Gu, Chenghua; De Palma, Michele; Kalluri, Raghu; LeBleu, Valerie S.. "Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2". Cell Reports 10 7 (2015): 1066-1081. http://dx.doi.org/10.1016/j.celrep.2015.01.035.
    10.1016/j.celrep.2015.01.035
  46. Xu, Xingbo; Tan, Xiaoying; Tampe, Björn; Nyamsuren, Gunsmaa; Liu, Xiaopeng; Maier, Lars S.; Sossalla, Samuel; et al. "Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis". Cardiovascular Research 105 3 (2015): 279-291. http://dx.doi.org/10.1093/cvr/cvv015.
    10.1093/cvr/cvv015
  47. Tampe, Björn; Tampe, Desiree; Zeisberg, Elisabeth M.; Müller, Gerhard A.; Bechtel-Walz, Wibke; Koziolek, Michael; Kalluri, Raghu; Zeisberg, Michael. "Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease". EBioMedicine 2 1 (2015): 19-36. http://dx.doi.org/10.1016/j.ebiom.2014.11.005.
    10.1016/j.ebiom.2014.11.005
  48. Melo, Sonia A.; Sugimoto, Hikaru; O’Connell, Joyce T.; Kato, Noritoshi; Villanueva, Alberto; Vidal, August; Qiu, Le; et al. "Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis". Cancer Cell 26 5 (2014): 707-721. http://dx.doi.org/10.1016/j.ccell.2014.09.005.
    10.1016/j.ccell.2014.09.005
  49. Zeisberg, Michael; Tampe, Björn; LeBleu, Valerie; Tampe, Desiree; Zeisberg, Elisabeth M.; Kalluri, Raghu. "Thrombospondin-1 Deficiency Causes a Shift from Fibroproliferative to Inflammatory Kidney Disease and Delays Onset of Renal Failure". The American Journal of Pathology 184 10 (2014): 2687-2698. http://dx.doi.org/10.1016/j.ajpath.2014.06.014.
    10.1016/j.ajpath.2014.06.014
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  249. Kalluri, R.; Sukhatme, V.P.. "Fibrosis and angiogenesis". Current Opinion in Nephrology and Hypertension 9 4 (2000): 413-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033936187&partnerID=MN8TOARS.
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  252. Wolf, G.; Kalluri, R.; Ziyadeh, F.N.; Neilson, E.G.; Stahl, R.A.K.. "Angiotensin II induces a3(IV) collagen expression in cultured murine proximal tubular cells". Proceedings of the Association of American Physicians 111 4 (1999): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779513&partnerID=MN8TOARS.
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  256. Lei, H.; Furth, E.E.; Kalluri, R.; Wakenell, P.; Kallen, C.B.; Jeffrey, J.J.; Leboy, P.S.; Strauss III, J.F.. "Induction of matrix metalloproteinases and collagenolysis in chick embryonic membranes before hatching". Biology of Reproduction 60 1 (1999): 183-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032919982&partnerID=MN8TOARS.
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  259. Bergijk, E.C.; Van Alderwegen, I.E.; Baelde, H.J.; De Heer, E.; Funabiki, K.; Miyai, H.; Killen, P.D.; Kalluri, R.K.; Bruijn, J.A.. "Differential expression of collagen IV isoforms in experimental glomerulosclerosis". Journal of Pathology 184 3 (1998): 307-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031939550&partnerID=MN8TOARS.
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  262. Minto, A.W.; Kalluri, R.; Togawa, M.; Bergijk, E.C.; Killen, P.D.; Salant, D.J.. "Augmented expression of glomerular basement membrane specific type IV collagen isoforms (a3-a5) in experimental membranous nephropathy". Proceedings of the Association of American Physicians 110 3 (1998): 207-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031859651&partnerID=MN8TOARS.
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  272. Lei, H.; Furth, E.E.; Kalluri, R.; Chiou, T.; Tilly, K.I.; Tilly, J.L.; Elkon, K.B.; Jeffrey, J.J.; Strauss III, J.F.. "A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor". Journal of Clinical Investigation 98 9 (1996): 1971-1978. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029861795&partnerID=MN8TOARS.
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  274. Ortiz-Arduan, A.; Danoff, T.M.; Kalluri, R.; Gonzalez-Cuadrado, S.; Karp, S.L.; Elkon, K.; Egido, J.; Neilson, E.G.. "Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia". American Journal of Physiology - Renal Fluid and Electrolyte Physiology 271 6 40-6 (1996): http://www.scopus.com/inward/record.url?eid=2-s2.0-0030460595&partnerID=MN8TOARS.
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  278. Boutaud, A.A.; Kalluri, R.; Kahsai, T.Z.; Noelken, M.E.; Hudson, B.G.. "Goodpasture syndrome: Selective removal of anti-a3(IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis". Experimental Nephrology 4 4 (1996): 205-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029784378&partnerID=MN8TOARS.
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  280. Kalluri, R.; Petrides, S.; Wilson, C.B.; Tomaszewski, J.E.; Palevsky, H.I.; Grippi, M.A.; Madaio, M.P.; Neilson, E.G.. "Anti-a1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the goodpasture syndrome". Annals of Internal Medicine 124 7 (1996): 651-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029665070&partnerID=MN8TOARS.
  281. Peissel, B.; Geng, L.; Kalluri, R.; Kashtan, C.; Rennke, H.G.; Gallo, G.R.; Yoshioka, K.; et al. "Comparative distribution of the a1 (IV), a5(IV), and a6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients". Journal of Clinical Investigation 96 4 (1995): 1948-1957. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028802644&partnerID=MN8TOARS.
  282. Kalluri, R.; Van den Heuvel, L.P.; Smeets, H.J.M.; Schroder, C.H.; Lemmink, H.H.; Boutaud, A.; Neilson, E.G.; Hudson, B.G.. "A COL4A3 gene mutation and post-transplant anti-a3(IV) collagen alloantibodies in Alport syndrome". Kidney International 47 4 (1995): 1199-1204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028945633&partnerID=MN8TOARS.
  283. Kalluri, R.; Wilson, C.B.; Weber, M.; Gunwar, S.; Chonko, A.M.; Neilson, E.G.; Hudson, B.G.. "Identification of the a3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome". Journal of the American Society of Nephrology 6 4 (1995): 1178-1185. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028789911&partnerID=MN8TOARS.
  284. Ding, J.; Kashtan, C.E.; Fan, W.W.; Kleppel, M.M.; Sun, M.J.; Kalluri, R.; Neilson, E.G.; Michael, A.F.. "A monoclonal antibody marker for Alport syndrome identifies the Alport antigen as the a5 chain of type IV collagen". Kidney International 45 5 (1994): 1504-1506. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028330824&partnerID=MN8TOARS.
  285. Kalluri, R.; Gattone II, V.H.; Noelken, M.E.; Hudson, B.G.. "The a3 chain of type IV collagen induces autoimmune Goodpasture syndrome". Proceedings of the National Academy of Sciences of the United States of America 91 13 (1994): 6201-6205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028173801&partnerID=MN8TOARS.
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  286. Kalluri, R.; Gattone II, V.H.; Noelken, M.E.; Hudson, B.G.. "Erratum: The a3 chain of type IV collagen induces autoimmune Goodpasture syndrome (Proceedings of the National Academy of Sciences of the United States of America (June 21, 1994) 91:13 (6201-6205)". Proceedings of the National Academy of Sciences of the United States of America 91 19 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028598539&partnerID=MN8TOARS.
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  288. Noelken, M.E.; Reddy, G.K.; Kalluri, R.; Gunwar, S.; Hudson, B.G.. "The chain composition of aorta basement membrane collagen IV, localization of the chains in aorta and supramolecular assembly of the collagen IV protomers.". Contributions to nephrology 107 (1994): 216-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028318049&partnerID=MN8TOARS.
  289. Kalluri, R.; Weber, M.; Netzer, K.-O.; Sun, M.J.; Neilson, E.G.; Hudson, B.G.. "COL4A5 gene deletion and production of post-transplant anti-a3(IV) collagen alloantibodies in Alport syndrome". Kidney International 45 3 (1994): 721-726. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028329547&partnerID=MN8TOARS.
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Intellectual property

Patent
  1. Kalluri, Raghu; Zeisberg, Michael; Zeisberg, Elisabeth; Tampe, Björn; Anton, Gerhard; Xingbo, Xu; Tampe, Desiree. 2020. "Treatment of Aberrant Fibroblast Proliferation". United States.
    Granted/Issued
  2. Kalluri, Raghu; LeBleu, Valerie. 2019. "Immuno-Exosomes and Methods of Use Thereof". United States.
    Granted/Issued
  3. Kalluri, Raghu. 2019. "Identification of Epigenetic Alterations in DNA Isolated from Exosomes". United States.
    Granted/Issued
  4. Kalluri, Raghu. 2019. "Therapeutic Targeting of Oncogenes Using Exosomes, United States". United States.
    Granted/Issued
  5. Kalluri, Raghu. 2019. "Therapeutic Modulation of Tumor Suppressors Using Exosomes". United States.
  6. Kalluri, Raghu. 2019. "Isolation and Detection of Exosome-Associated Microbiome for Diagnostic and Therapeutic Purposes". United States.
    Granted/Issued
  7. Kalluri, Raghu. 2019. "Telomerase-Containing Exosomes for Treatment of Diseases Associated with Aging and Age-Related Organ Dysfunction". United States.
    Granted/Issued
  8. Kalluri, Raghu; LeBleu, Valerie; Correa de Sampaio, Pedro. 2019. "Use of Exosomes for Targeted Delivery of Therapeutic Agents". United States.
    Granted/Issued
  9. Kalluri, Raghu. 2019. "Targeting Alpha3Beta1 Integrin for Treatment of Cancer and Other Disease". United States.
    Granted/Issued
  10. Kalluri, Raghu; LeBleu, Valerie; Chen, Yang. 2019. "Compositions for and Methods of Producing Tumor Organoids". United States.
    Granted/Issued
  11. Kalluri, Raghu; LeBleu, Valerie; Chen, Yang. 2019. "Identification and Targeting of Pathogenic Extracellular Matrix for Diagnosis and Treatment of Cancer and Other Disease". United States.
    Granted/Issued
  12. Kalluri, Raghu. 2018. "Identification and Targeting of Tumor Promoting Carcinoma Associated Fibroblasts for Diagnosis and Treatment of Cancer and Other Diseases". United States.
    Granted/Issued
  13. Kalluri, Raghu; LeBleu, Valerie; Xiao, Fei. 2018. "Methods and Compositions for Treating Cancer Using Exosomes-Associated Gene Editing". United States.
    Granted/Issued
  14. Kalluri, Raghu; Shpall, Elizabeth; Rezvani, Katy; Mendt, Mayela; LeBleu, Valerie; Kamerkar, Sushrut. 2017. "Methods for Production of MSC-Derived Exosomes". United States.
    Granted/Issued
Distinctions

Award

2016 Ruth Leff Siegel Award for Excellence in Pancreatic Cancer Research
Columbia University Irving Medical Center, United States
2010 Folkman Award Lectureship
Mayo Clinic School of Continuous Professional Development, United States
2009 Champalimaud Investigator Award
Fundação Champalimaud, Portugal
2008 Outstanding Achievement Award in Cancer Research
Society of American Asian Scientists in Cancer Research, United States
2007 Everett Mendelsohn Excellence in Mentoring Award
Harvard Graduate Student Council, United States
2007 Young Mentor Award
Harvard Medical School, United States
2006 Center for Faculty Development Award for Excellence in Mentoring
Beth Israel Deaconess Medical Center, United States
2005 Young Investigator Award
American Society of Nephrology, United States

American Heart Association Inc, United States
1998 Carl Gottschalk Research Award
American Society of Nephrology, United States
1998 Enterprise Award
Beth Israel Deaconess Medical Center, United States
1998 Joseph Murray Award
National Kidney Foundation, United States
1998 Prostate Cancer Research Award
Hershey Co, United States
1997 Young Investigator Travel Award
International Society of Nephrology, United States
1995 Young Investigator Travel Award
National Institute of Diabetes and Digestive and Kidney Diseases, United States
1994 Young Investigator Travel Award
American Society of Biochemistry and Molecular Biology, United States

Other distinction

2017 GRACE Distinguished Lecturer
ISREC-SCCL Symposium - Lausanne University, Switzerland
2016 Fellow
American Society of Nephrology, United States
2016 RE "Bob" Smith Distinguished Chair in Cancer Biology
University of Texas MD Anderson Cancer Center, United States
2015 Jacob Henle Medal for Excellence in Medicine
Georg-August-Universität Göttingen, Germany
2014 Rebecca Meyer Brown & Joseph Mellinger Brown Chair Award in Basic Science Research
University of Texas MD Anderson Cancer Center, United States
2012 Fellow
American Association for the Advancement of Science, United States
2010 Fellow
The American Society for Clinical Investigation, United States
2007 G.B. Stastry Gold Medal for Contributions to Medicine
Andhra University, India
2000 Top Research List
Beth Israel Deaconess Medical Center, United States
1992 Top Five Graduate Researchers
University of Kansas, United States
1988 Gold Medal in Genetics
Osmania University, India