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Alexandre Carmo. Principal Investigator, IBMC - Institute of Molecular and Cellular Biology, and i3S - Institute of Investigation and Innovation in Health, University of Porto, Portugal
Identification

Personal identification

Full name
Alexandre Carmo

Citation names

  • Carmo, Alexandre
  • Alexandre M Carmo

Author identifiers

Ciência ID
5A14-6B60-7C2C
ORCID iD
0000-0002-2508-9799
Google Scholar ID
https://scholar.google.pt/citations?user=kO1md-4AAAAJ&hl=pt-PT
Researcher Id
B-5191-2011
Scopus Author Id
6603934048

Email addresses

  • acarmo@ibmc.up.pt (Professional)

Telephones

Telephone
  • 226074911 (Professional)

Addresses

  • Instituto de Biologia Molecular e Celular. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
Education
Degree Classification
1991/11/17 - 1995/07/29
Concluded
Immunology (Doctor of Philosophy)
University of Oxford Wolfson College, United Kingdom
"Molecular associations of proteins involved in signal transduction in T lymphocytes" (THESIS/DISSERTATION)
1987/12/13 - 1991/01/11
Concluded
Mestrado em Imunologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The influence of culture conditions of peripheral blood mononuclear cells on the expression of T lymphocyte specific genes" (THESIS/DISSERTATION)
Muito Bom
1982/10/01 - 1987/12/12
Concluded
Bioquímica (Licenciatura)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
16
Affiliation

Science

Category
Host institution
Employer
2015/11/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2008/04/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/09/01 - 2009/07/31 Visiting Researcher (Research) Weatherall Institute of Molecular Medicine, United Kingdom
Weatherall Institute of Molecular Medicine, United Kingdom
1999/04/01 - 2008/03/31 Auxiliary Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2009/12/01 - 2015/09/30 Invited Associate Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Grant

Designation Funders
2025/01/01 - 2026/06/30 A novel role for CD5L in modulating the immune responses against protozoan parasites
2023.14474.PEX
2023.14474.PEX
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Characterization of invariant Natural Killer T cell phenotype and function in alpha-Galactosidase A deficiency
2022.01788.PTDC
Researcher
Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2024/06/30 A novel role for SRCR proteins at the interface of maternal-fetal infections associated with neonatal sepsis
2022.04792.PTDC
2022.04792.PTDC
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/12/31 BRAINFLAMME - CD6 as a regulator of T cell signaling and a hotspot for treating neuroinflammation
PTDC/MED-IMU/32296/2017
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01/01 - 2020/12/31 FOLSMART - Folate-target nanodevices to activate macrophages for rheumatoid arthritis.
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
European Commission
Concluded
2016/02/01 - 2020/01/31 SRECOGNITE – SRCR proteins as microorganism pattern recognition receptors: a wide search for interactions with pathogenic bacteria
Infect-ERA 2015 - ID 121
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2016/04 - 2019/03 Immunomodulatory effect of CD6-targeting in neuroinflammation
PTDC/DTP-FTO/3080/2014
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/06/01 - 2015/09/30 Do scavenger receptor cysteine-rich proteins interact with host immune mediators or bind pathogen-associated molecular patterns: a comprehensive qualitative and quantitative analysis.
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2012/04/01 - 2015/06/30 Global analysis of alternative polyadenylation regulators and miRNA silencing of immune modulators
PTDC/SAU-GMG/116621/2010
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Baylor College of Medicine, United States
Fundação para a Ciência e a Tecnologia
Concluded
2009/12 - 2013/11 NANOFOL - Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases.
NMP4-LA-2009-228827
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
European Commission
Concluded
2010/04/01 - 2013/09/30 Functional and biological characterization of SSc5D, a novel molecule of the Scavenger Receptor Cysteine-rich family
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/01/01 - 2013/04/30 A systematic method for identifying the ligands of T-cell surface molecules
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2008/06/01 - 2011/05/31 Alternative spliced isoforms of CD6: on the cross-roads of T cell activation and the regulation of lymphocyte development
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/07/01 - 2008/06/30 Multiple isoforms of CD6 that arise from alternative splicing: their role in the regulation of T cell signaling and at the immunological synapse
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/04/01 - 2008/03/31 Analysis of CD5 expression at the surface of T lymphocytes: molecular associations and membrane domain localization
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2002/02/01 - 2005/01/31 The biology of the Scavenger receptor cysteine-rich family: CD6 as a model.
POCTI/MGI/39071/2001
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2001/05 - 2004/10 Targeting signaling pathways as therapy for human cancer
POCTI/CBO/34914/99
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Carmo, Alexandre M.; Henriques, Sónia N.. "Cell Activation and Signaling in Lymphocytes". In Tissue-Specific Cell Signaling, 133-161. Springer International Publishing, 2020.
    10.1007/978-3-030-44436-5_5
  2. Oliveira, Liliana; Santos, Rita F.; Carmo, Alexandre M.. "CD6". In Encyclopedia of Signaling Molecules, 937-943. Springer International Publishing, 2018.
    10.1007/978-3-319-67199-4_101856
  3. Carmo AM; Sreenu VB. "Systematic analysis of Scavenger Receptor Cysteine-rich family domains encoded in the Human Genome". In Bioinformatics – Trends and methodologies, 195-210. London, United Kingdom: InTech, 2011.
Journal article
  1. Cardoso, M.S.; Gonçalves, R.; Oliveira, L.; Silvério, D.; Téllez, É.; Paul, T.; Sarrias, M.R.; Carmo, A.M.; Saraiva, M.. "CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression". Immunology (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85196625668&partnerID=MN8TOARS.
    10.1111/imm.13825
  2. Santos, R.F.; de Sousa Linhares, A.; Steinberger, P.; Davis, S.J.; Oliveira, L.; Carmo, A.M.. "The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling". Cell Communication and Signaling 22 1 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85194218997&partnerID=MN8TOARS.
    10.1186/s12964-024-01658-y
  3. Oliveira L; Silva MC; Gomes AP; Santos RF; Cardoso MS; Nóvoa A; Luche H; et al. "CD5L as a promising biological therapeutic for treating sepsis". Nature Communications 15 1 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85193351776&partnerID=MN8TOARS.
    Accepted • 10.1038/s41467-024-48360-8
  4. Henriques, Sónia N.; Oliveira, Liliana; Santos, Rita F.; Carmo, Alexandre M.. "CD6-mediated inhibition of T cell activation via modulation of Ras". Cell Communication and Signaling 20 1 (2022): http://dx.doi.org/10.1186/s12964-022-00998-x.
    10.1186/s12964-022-00998-x
  5. Cardoso, M.S.; Santos, R.F.; Almeida, S.; Sá, M.; Pérez-Cabezas, B.; Oliveira, L.; Tavares, J.; Carmo, A.M.. "Physical Interactions With Bacteria and Protozoan Parasites Establish the Scavenger Receptor SSC4D as a Broad-Spectrum Pattern Recognition Receptor". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85122481820&partnerID=MN8TOARS.
    10.3389/fimmu.2021.760770
  6. Carmo, A.M.; Love, P.E.; Marshall, A.J.. "Editorial: Inhibitory Receptors and Pathways of Lymphocytes". Frontiers in Immunology 11 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85089088008&partnerID=MN8TOARS.
    10.3389/fimmu.2020.01552
  7. Santos, R.F.; Oliveira, L.; Brown, M.H.; Carmo, A.M.. "Domain-specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative-splicing". Immunology 157 4 (2019): 296-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068083912&partnerID=MN8TOARS.
    10.1111/imm.13087
  8. Freitas, R.F.; Basto, A.; Almeida, S.C.P.; Santos, R.F.; Gonçalves, C.M.; Corria-Osorio, J.; Carvalho, T.; et al. "Modulation of CD4 T cell function via CD6-targeting". EBioMedicine 47 (2019): 427-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072256661&partnerID=MN8TOARS.
    10.1016/j.ebiom.2019.08.008
  9. Gonçalves, C.M.; Henriques, S.N.; Santos, R.F.; Carmo, A.M.. "CD6, a rheostat-type signalosome that tunes T cell activation". Frontiers in Immunology 9 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059925855&partnerID=MN8TOARS.
    10.3389/fimmu.2018.02994
  10. Carvalho, D.O.; Freitas, J.; Nogueira, P.; Henriques, S.N.; Carmo, A.M.; Castro, M.A.; Guido, L.F.. "Xanthohumol inhibits cell proliferation and induces apoptosis in human thyroid cells". Food and Chemical Toxicology 121 (2018): 450-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054021358&partnerID=MN8TOARS.
    10.1016/j.fct.2018.09.021
  11. Nogueira, E.; Freitas, J.; Loureiro, A.; Nogueira, P.; Gomes, A.C.; Preto, A.; Carmo, A.M.; Moreira, A.; Cavaco-Paulo, A.. "Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages". Colloids and Surfaces B: Biointerfaces 155 (2017): 459-465. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019046361&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.04.023
  12. Oliveira, L.; Carmo, A.M.. "Response: Commentary: the scavenger receptor SSc5D physically interacts with bacteria through the SrCr-containing n-terminal domain". Frontiers in Immunology 8 AUG (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028352791&partnerID=MN8TOARS.
    10.3389/fimmu.2017.01004
  13. Domingues, R.G.; Lago-Baldaia, I.; Pereira-Castro, I.; Fachini, J.M.; Oliveira, L.; Drpic, D.; Lopes, N.; et al. "CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204". European Journal of Immunology 46 6 (2016): 1490-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973661630&partnerID=MN8TOARS.
    10.1002/eji.201545663
  14. Santos, R.F.; Oliveira, L.; Carmo, A.M.. "Tuning T cell activation: The function of CD6 at the immunological synapse and in T cell responses". Current Drug Targets 17 6 (2016): 630-639. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964055216&partnerID=MN8TOARS.
  15. Nogueira, E.; Cruz, C.F.; Loureiro, A.; Nogueira, P.; Freitas, J.; Moreira, A.; Carmo, A.M.; et al. "Assessment of liposome disruption to quantify drug delivery in vitro". Biochimica et Biophysica Acta - Biomembranes 1858 2 (2016): 163-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948166510&partnerID=MN8TOARS.
    10.1016/j.bbamem.2015.11.008
  16. Carmo, A.M.. "Heads or tails: Betting on CD6 as a resurged target for autoimmune diseases and sepsis". Current Drug Targets 17 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964057697&partnerID=MN8TOARS.
  17. Pereira, C.B.; Bocková, M.; Santos, R.F.; Santos, A.M.; de Araújo, M.M.; Oliveira, L.; Homola, J.; Carmo, A.M.. "The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain". Frontiers in Immunology 7 OCT (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997514499&partnerID=MN8TOARS.
    10.3389/fimmu.2016.00416
  18. Nogueira, E.; Lager, F.; Le Roux, D.; Nogueira, P.; Freitas, J.; Charvet, C.; Renault, G.; et al. "Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice". Journal of Biomedical Nanotechnology 11 12 (2015): 2243-2252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941551653&partnerID=MN8TOARS.
    10.1166/jbn.2015.2170
  19. Nogueira, E.; Mangialavori, I.C.; Loureiro, A.; Azoia, N.G.; Sárria, M.P.; Nogueira, P.; Freitas, J.; et al. "Peptide Anchor for Folate-Targeted Liposomal Delivery". Biomacromolecules 16 9 (2015): 2904-2910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941584525&partnerID=MN8TOARS.
    10.1021/acs.biomac.5b00823
  20. Da Glória, V.G.; De Araújo, M.M.; Santos, A.M.; Leal, R.; De Almeida, S.F.; Carmo, A.M.; Moreira, A.. "T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1". Journal of Immunology 193 1 (2014): 391-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903626125&partnerID=MN8TOARS.
    10.4049/jimmunol.1400038
  21. Brisslert, M.; Bian, L.; Svensson, M.N.D.; Santos, R.F.; Jonsson, I.-M.; Barsukov, I.; Erlandsson, M.; et al. "S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis". Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 11 (2014): 2049-2059. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907983758&partnerID=MN8TOARS.
    10.1016/j.bbadis.2014.07.003
  22. Pinto, M.; Carmo, A.M.. "CD6 as a therapeutic target in autoimmune diseases: Successes and challenges". BioDrugs 27 3 (2013): 191-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878559392&partnerID=MN8TOARS.
    10.1007/s40259-013-0027-4
  23. Nogueira, E.; Loureiro, A.; Nogueira, P.; Freitas, J.; Almeida, C.R.; Härmark, J.; Hebert, H.; et al. "Liposome and protein based stealth nanoparticles". Faraday Discussions 166 (2013): 417-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887481690&partnerID=MN8TOARS.
    10.1039/c3fd00057e
  24. Henriques, T.; Ji, Z.; Tan-Wong, S.M.; Carmo, A.M.; Tian, B.; Proudfoot, N.J.; Moreira, A.. "Transcription termination between polo and snap, two closely spaced tandem genes of D. melanogaster.". Transcription 3 4 (2012): 198-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873285818&partnerID=MN8TOARS.
  25. Rollett, A.; Reiter, T.; Nogueira, P.; Cardinale, M.; Loureiro, A.; Gomes, A.; Cavaco-Paulo, A.; et al. "Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages". International Journal of Pharmaceutics 427 2 (2012): 460-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859105871&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.02.028
  26. Oliveira, M.I.; Gonçalves, C.M.; Pinto, M.; Fabre, S.; Santos, A.M.; Lee, S.F.; Castro, M.A.A.; et al. "CD6 attenuates early and late signaling events, setting thresholds for T-cell activation". European Journal of Immunology 42 1 (2012): 195-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855225261&partnerID=MN8TOARS.
    10.1002/eji.201040528
  27. James, J.R.; McColl, J.; Oliveira, M.I.; Dunne, P.D.; Huang, E.; Jansson, A.; Nilsson, P.; et al. "The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins". Journal of Biological Chemistry 286 37 (2011): 31993-32001. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052730531&partnerID=MN8TOARS.
    10.1074/jbc.M111.219212
  28. Pinto, P.A.B.; Henriques, T.; Freitas, M.O.; Martins, T.; Domingues, R.G.; Wyrzykowska, P.S.; Coelho, P.A.; et al. "RNA polymerase II kinetics in polo polyadenylation signal selection". EMBO Journal 30 12 (2011): 2431-2444. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958859723&partnerID=MN8TOARS.
    10.1038/emboj.2011.156
  29. Bamberger, M.; Santos, A.M.; Gonçalves, C.M.; Oliveira, M.I.; James, J.R.; Moreira, A.; Lozano, F.; Davis, S.J.; Carmo, A.M.. "A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of fyn kinase". Journal of Biological Chemistry 286 35 (2011): 30324-30336. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052235105&partnerID=MN8TOARS.
    10.1074/jbc.M111.230102
  30. Fernandes, R.A.; Yu, C.; Carmo, A.M.; Evans, E.J.; Anton van der Merwe, P.; Davis, S.J.. "What Controls T Cell Receptor Phosphorylation?". Cell 142 5 (2010): 668-669. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956167214&partnerID=MN8TOARS.
    10.1016/j.cell.2010.08.018
  31. Gonçalves, C.M.; Castro, M.A.A.; Henriques, T.; Oliveira, M.I.; Pinheiro, H.C.; Oliveira, C.; Sreenu, V.B.; et al. "Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily". Molecular Immunology 46 13 (2009): 2585-2596. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650569240&partnerID=MN8TOARS.
    10.1016/j.molimm.2009.05.006
  32. Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M.. "Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2". Journal of Immunology 180 2 (2008): 988-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-40449133966&partnerID=MN8TOARS.
  33. Coelho, P.A.; Queiroz-Machado, J.; Carmo, A.M.; Moutinho-Pereira, S.; Maiato, H.; Sunkel, C.E.. "Dual role of topoisomerase II in centromere resolution and aurora B activity". PLoS Biology 6 8 (2008): 1758-1777. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249129235&partnerID=MN8TOARS.
    10.1371/journal.pbio.0060207
  34. Kearney, A.; Avramovic, A.; Castro, M.A.A.; Carmo, A.M.; Davis, S.J.; Van Der Merwe, P.A.. "The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction". Journal of Biological Chemistry 282 18 (2007): 13160-13166. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250370503&partnerID=MN8TOARS.
    10.1074/jbc.M700829200
  35. Castro, M.A.A.; Oliveira, M.I.; Nunes, R.J.; Fabre, S.; Barbosa, R.; Peixoto, A.; Brown, M.H.; et al. "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". Journal of Immunology 178 7 (2007): 4351-4361. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947649690&partnerID=MN8TOARS.
  36. Evans, E.J.; Castro, M.A.A.; O'Brien, R.; Kearney, A.; Walsh, H.; Sparks, L.M.; Tucknott, M.G.; et al. "Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48". Journal of Biological Chemistry 281 39 (2006): 29309-29320. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749378972&partnerID=MN8TOARS.
    10.1074/jbc.M601314200
  37. James, J.R.; Oliveira, M.I.; Carmo, A.M.; Iaboni, A.; Davis, S.J.. "A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer". Nature Methods 3 12 (2006): 1001-1006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751215258&partnerID=MN8TOARS.
    10.1038/nmeth978
  38. Nunes, R.J.; Castro, M.A.A.; Carmo, A.M.. "Protein crosstalk in lipid rafts". Advances in Experimental Medicine and Biology 584 (2006): 127-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934439684&partnerID=MN8TOARS.
    10.1007/0-387-34132-3_10
  39. Castro, M.A.A.; Nunes, R.J.; Oliveira, M.I.; Tavares, P.A.; Simões, C.; Parnes, J.R.; Moreira, A.; Carmo, A.M.. "OX52 is the rat homologue of CD6: Evidence for an effector function in the regulation of CD5 phosphorylation". Journal of Leukocyte Biology 73 1 (2003): 183-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037241608&partnerID=MN8TOARS.
    10.1189/jlb.0902437
  40. Castro, M.A.A.; Tavares, P.A.; Almeida, M.S.; Nunes, R.J.; Wright, M.D.; Mason, D.; Moreira, A.; Carmo, A.M.. "CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains". European Journal of Immunology 32 5 (2002): 1509-1518. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036104886&partnerID=MN8TOARS.
    10.1002/1521-4141(200205)32:5<1509::AID-IMMU1509>3.0.CO;2-T
  41. Carmo, A.M.; Castro, M.A.A.; Arosa, F.A.. "CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells". Journal of Immunology 163 8 (1999): 4238-4245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032828669&partnerID=MN8TOARS.
  42. Arosa, F.A.; De Jesus, O.; Porto, G.; Carmo, A.M.; De Sousa, M.. "Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules". Journal of Biological Chemistry 274 24 (1999): 16917-16922. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033546416&partnerID=MN8TOARS.
    10.1074/jbc.274.24.16917
  43. Carmo, A.M.; Wright, M.D.. "Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity". European Journal of Immunology 25 7 (1995): 2090-2095. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029067385&partnerID=MN8TOARS.
    10.1002/eji.1830250743
  44. Garnett, D.; Neil Barclay, A.; Carmo, A.M.; Beyers, A.D.. "The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation". European Journal of Immunology 23 10 (1993): 2540-2544. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027431093&partnerID=MN8TOARS.
    10.1002/eji.1830231024
  45. Carmo, A.M.; Mason, D.W.; Beyers, A.D.. "Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56 lck and p59 fyn". European Journal of Immunology 23 9 (1993): 2196-2201. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027218372&partnerID=MN8TOARS.
    10.1002/eji.1830230922
Working paper
  1. Oliveira, L.; Gomes, A.P.; Santos, R.F.; Cardoso, M.S.; Nóvoa, A.; Luche, H.; Gartner, F.; et al. 2022. "CD5L constraints acute and systemic inflammation and can be a novel potent therapeutic agent against sepsis". https://www.biorxiv.org/content/10.1101/2022.03.08.483540v1.
    10.1101/2022.03.08.483540

Intellectual property

Patent
  1. Alexandre M Carmo; Oliveira, Liliana. 2022. "Recombinant Human CD5L protein, active fragments or peptides derived thereof and pharmaceutical composition comprising the recombinant human CD5L protein, active fragments or peptides derived thereof for the treatment of acute infectious diseases, inflammatory diseases and sepsis.". Portugal.
    Pending
Provisional application for patent
  1. 2020. "Scavenger circulating protein CD5L to treat inflammation-related diseases and sepsis".

Other

Other output
  1. Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma. 2024. dos Santos, N.R.; Pereira, J.; Ferreira, F.; Matos, A.; Pereira, D.; Santos, R.; Carmo, A.; Oliveira, M.; Machado, J.C.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85190557218&partnerID=MN8TOARS.
    10.21203/rs.3.rs-4018077/v1
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2012 - Current Liliana Oliveira - Post-doc/Junior Researcher
Supervisor of Liliana Oliveira
Pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2018/11/20 - 2023/11/03 Sónia Henriques PhD thesis - The T cell surface glycoprotein CD6 as an inhibitory receptor and as target for immunomodulation
Supervisor of Sónia Henriques
Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/11/08 - 2022/06/01 Marcos Cardoso PhD thesis - S4D-SRCRB protein as microorganism pattern recognition receptor: a wide search for interactions with pathogenic bacteria
Supervisor of Marcos Cardoso
Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07/01 - 2021/12/31 Carine Gonçalves - Junior Researcher
Supervisor of Carine Gonçalves
Pós-doutoramento (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2020/12/31 Diana Bicho - Post-doc
Supervisor of Diana Bicho
Post-doc (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2020/09/01 Rita Santos PhD thesis - Tuning T-cell activation: the molecular functions of CD5 and CD6 at the immunological synapse
Supervisor of Rita Santos
Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2018 Emma Comas - Post-doc
Supervisor of Emma Comas
Pós-doutoramento (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - 2017 Catarina Bessa Pereira PhD thesis - Functional and biological characterization of SSc5D, a novel molecule of the scavenger receptor cysteine–rich family
Supervisor of Catarina Bessa Pereira
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2015 Patrícia Nogueira - Post-doc
Supervisor of Patrícia Nogueira
Pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012 - 2013 Jaime Freitas - Post-doc
Supervisor of Jaime Freitas
Pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009 - 2013 Carine Gonçalves PhD thesis - Structural and functional role of CD6 in lymphocyte signaling
Supervisor of Carine Gonçalves
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2013 Mafalda Pinto - Post-doc
Supervisor of Mafalda Pinto
pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011 - 2012 Simon Lee - Post-doc
Supervisor of Simon Lee
Pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008 - 2012 Mafalda Santos PhD thesis - The T cell surface glycoprotein CD5: a regulatory hub in T cell signaling
Supervisor of Mafalda Santos
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2008 - 2011 Mafalda Araújo - Post-doc
Supervisor of Mafalda Araújo
Pós-doutoramento
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2004 - 2008 Martina Bamberger PhD thesis - CD5-mediated inhibition of T lymphocyte signaling
Supervisor of Martina Bamberger
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2003 - 2008 Raquel Nunes PhD thesis - The signaling role of the accessory receptors CD2 and CD6 in T cell activation
Supervisor of Raquel Nunes
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2003 - 2008 Mónica Castro - Post-doc
Supervisor of Mónica Castro
pós-doutoramento (Other)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2003 - 2007 Marta Oliveira PhD thesis - Molecular interactions at the T cell surface
Supervisor of Marta Oliveira
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1999 - 2003 Mónica Castro PhD thesis - Cell surface molecular associations of CD5: a role in signal transduction of T lymphocytes
Supervisor of Mónica Castro
Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2020 Born from Knowledge Award
Agência Nacional de Inovação SA, Portugal