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Tiago Barros Silva obtained his MSc in Pharmaceutical Sciences (2010) and PhD in Pharmaceutical Sciences (2016) from the Faculty of Pharmacy of the University of Porto. He has since worked as a postdoc in collaboration with three different research groups: the MedChem group led by F. Borges (CIQ/FCUP, Porto PT), MitoXT group led by P.J. Oliveira (Biocant/UC, Coimbra PT) and the KAS group led by K. Astakhova (DTU Chem, Copenhagen DK), developing projects in small molecule drug design, toxicology and nanotherapeutics. He is currently working on the development of smart dual-acting dopamine-enhacing inhibitors of ferroptosis for neurological disorders associated with dopamine depletion.
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Identification

Personal identification

Full name
Nuno Tiago Barros Silva

Citation names

  • Silva, T

Author identifiers

Ciência ID
5B11-6B6D-036B
ORCID iD
0000-0003-0874-5982
Google Scholar ID
Tiago Barros Silva
Scopus Author Id
25641749600

Email addresses

  • nuno.silva@fc.up.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
German Beginner (A1) Advanced (C1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016
Concluded
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Hydroxycinnamic acid, a valid scaffold for the development of CNS multitarget drugs. Synthesis, pharmacological and toxicological studies." (THESIS/DISSERTATION)
 Aprovado por unanimidade com distinção
2010
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Colesterol e Estatinas na Doença de Alzheimer." (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2017/06/01 - Current Postdoc (Research) CNC.IBILI, Portugal
2018/03/01 - 2018/06/15 Visiting Researcher (Research) Danmarks Tekniske Universitet, Denmark
2016/07/15 - 2017/05/31 Postdoc (Research) Universidade do Porto Centro de Investigação em Química, Portugal
2010/02/01 - 2010/06/01 Research Trainee (Research) Universidad Complutense de Madrid Facultad de Farmacia, Spain

Others

Category
Host institution 		Employer
2012/04/01 - 2016/04/01 PhD student, FCT Grant (SFRH /BD/79671/2011) Universidade do Porto Faculdade de Farmácia, Portugal
2011/03/15 - 2012/03/15 Research Grant, BP4BRAIN project (PTDC/QUI-QUI/113687/2009) Universidade do Porto Centro de Investigação em Química, Portugal
2010/06/01 - 2010/09/01 Pharmacy intern Farmácia Firmeza, Portugal
Projects

Grant

Designation Funders
2016/07/15 - 2017/06/30 SAM: Sustained Advanced Materials (NORTE-01-0145-FEDER-000028)
CIQ-SAM/BIOANTIOX-BPD2
Post-doc Fellow
Universidade do Porto Centro de Investigação em Química, Portugal
Ongoing
2011/03/15 - 2012/03/15 BP4Brain – Benzopirano: uma estrutura priveligiada para o desenho racional de compostos multi-alvo com aplicação potencial em doenças neurodegenerativas
PTDC/QUI-QUI/113687/2009
Research Fellow
Universidade do Porto Centro de Investigação em Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/05/22 - Current COMT4BRAIN: Development of centrally-active and safe catechol O-methyltransferase inhibitors
POCI-01-0145-FEDER-029164
Post-doc Fellow
Universidade do Porto Centro de Investigação em Química, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Ongoing
2016/10/01 - Current MitoBOOST - MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria
PTDC/DTP-FTO/2433/2014
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Silva, T. "Recycling bromovanillin into ferulic acid-based antioxidants". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 559-563. Royal Chemical Society, 2016.
  2. Silva, T. "Synthesis of lipophilic antioxidants based on natural models". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 380-386. Royal Chemical Society, 2016.
Conference abstract
  1. Silva, T. "In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols". Paper presented in EUROTOX 2016: 52nd Congress of the European Societies of Toxicology. Toxicol. Lett, 2016, 258, S131, Sevilla, 2016.
  2. Silva, T. "Targeting dietary phenolic acids to mitochondria: improving hydroxybenzoic acids antioxidant properties". Paper presented in 49th Annual Scientific Meeting of the European Society for Clinical Investigation., Cluj-Napoca, 2015.
  3. Silva, T. "Development of neuroprotective antioxidants: In vitro and cellular activity of lipophilic cinnamic acid derivatives". Paper presented in EUROTOX 2014: 50th Congress of the European Societies of Toxicology. Toxicol Lett 2014, 229, Suppl., S80, Edimburgh, 2014.
    https://doi.org/10.1016/j.toxlet.2014.06.305
  4. Silva, T. "New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants". Paper presented in EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem 2012, PO21, Berlin, 2012.
  5. Silva, T. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Paper presented in EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem 2012, PO84, Berlin, 2012.
  6. Silva, T. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Paper presented in Society for Free Radical Research International 16th Biennial Meeting. Free Rad Biol Med., London, 2012.
  7. Silva, T. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Paper presented in Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies” Purinergic Signalling volume 6, pages49–115 (2010), Camerino, 2010.
    doi.org/10.1007/s11302-009-9171-1
  8. Silva, T. "Targeting cinnamic antioxidants to mitochondria: a new therapeutic direction on neurodegenerative diseases". Paper presented in Frontiers in medicinal chemistry: Emerging targets, novel candidates and innovative strategies., Barcelona, 2009.
  9. Silva, T. "Chromone-based adenosine ligands as a new challenge in drug development for the treatment of neurological disorders: the story so far". Paper presented in Frontiers in medicinal chemistry: Emerging targets, novel candidates and innovative strategies, Barcelona, 2009.
Conference poster
  1. Silva, T. "An atypical catechol O-methyltransferase inhibitor is a remarkable modulator of hypoxia in HeLa cells". Paper presented in MuTaLig COST ACTION CA15135 WG1 Meeting 2020 Izmir (Turkey), 2020.
  2. Silva, T. "Benzoic acid-derived nitrones: a new class of acetylcholinesterase inhibitors and potential neuroprotective agents". Paper presented in IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting. Catanzaro, Italy., 2019.
  3. Silva, T. "Hydroxypyridin-4-ones are a versatile scaffold to develop copper(II)-chelating COMT inhibitors with neuroprotective properties". Paper presented in IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting. Catanzaro, Italy., 2019.
  4. Silva, T. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Paper presented in 26th Young Research Fellows meeting. Paris, France., 2019.
  5. Silva, T. "Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors". Paper presented in 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  6. Silva, T. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Paper presented in 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  7. Silva, T. "Development of Dual Acting COMT Inhibitors and Iron Chelators: Studies on Synthetic Routes Optimization". Paper presented in 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  8. Silva, T. "Development of Novel Phenolic and Thiophenolic Antioxidants based on Cinnamic Acid Scaffold". Paper presented in 8th meeting of Paul Ehrlich MedChem EuroPhD Network. Porto, Portugal., 2018.
  9. Silva, T. "Synthesis of Non-Nitrocatechol COMT Inhibitors". Paper presented in 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, July 12th-14th, 2018, 2018.
  10. Silva, T. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Paper presented in 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, July 12th-14th, 2018, 2018.
  11. Silva, T. "Hydroxycinnamic acid derivatives and sulfured analogues: from synthesis to antioxidant properties". Paper presented in 2nd WG meeting – Status of WG activities of the MuTaLig COST Action (CA15135). Tenerife, Spain., 2018.
  12. Silva, T. "Natural products in drug discovery: enhancing the antioxidant profile of hydroxycinnamic acids". Paper presented in EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  13. Silva, T. "Microencapsulation as a strategy to improve the ADMET properties of bioactive caffeic acid derivatives". Paper presented in EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  14. Silva, T. "Hydroxybenzoic acid-based mitochondriotropic antioxidants as cholinesterase inhibitors". Paper presented in EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  15. Silva, T. "Design, synthesis and neuroprotective properties of new hydroxycinnamic acid-based antioxidants". Paper presented in 7th meeting of Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, August 25th-27th, 2017, 2017.
  16. Silva, T. "Effect of the acid strength on the antioxidant profile of natural and synthetic antioxidants". Paper presented in 37th Edition of the European School of Medicinal Chemistry (ESMEC). Urbino, Italy., 2017.
  17. Silva, T. "Optimizing nature: development of novel antioxidants based on ferulic acid". Paper presented in 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept. Budapest, Hungary., 2016.
  18. Silva, T. "Insights on the development of novel neuroprotective agents: a comparative study between ferulic acid and related sulfanyl derivatives". Paper presented in 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept. Budapest, Hungary., 2016.
  19. Silva, T. "In vitro cellular and mitochondrial toxicity and tolcapone and related nitrocatechols". Paper presented in EUROTOX2016: 52nd European Congress of the European Societies of Toxicology. Seville, Spain., 2016.
  20. Silva, T. "Enhancement of solubility and bioavailability of caffeic acid phenethyl ester using cyclodextrin inclusion complexes". Paper presented in IX Encontro de Jovens Investigadores da Universidade do Porto. Porto, Portugal., 2016.
  21. Silva, T. "Desenvolvimento de novos agentes neurotróficos baseados no ácido hidroxicinâmico". Paper presented in I Encontro Científico do Núcleo de Estudantes de Química/Associação Académica de Coimbra (NEQ/AAC). Coimbra, Portugal., 2015.
  22. Silva, T. "Electrochemical and antioxidant activity of diene derivatives inspired on natural hydroxycinnamic acids". Paper presented in XX Meeting of the Portuguese Electrochemical Society (XXSNSPE). Braga, Portugal., 2015.
  23. Silva, T. "Development of Novel Neuroprotective Antioxidants Inspired on Hydroxycinnamic Acid Scaffold". Paper presented in V Meeting of the Paul Ehrlich Euro-PhD Network. Krakow, Poland., 2015.
  24. Silva, T. "Development of multitarget-directed nitrocinnamic derivatives endowed with neuroprotective properties". Paper presented in International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress. Rome, Italy., 2015.
  25. Silva, T. "Development of hybrid arylnitrones antioxidants for ameliorating the oxidative stress associated with Alzheimer disease". Paper presented in ESMEC 2015 - European School of Medicinal Chemistry (ESMEC), Urbino, Italy, June 28th – July 3rd, 2015, 2015.
  26. Silva, T. "Targeting dietary phenolic acids to mitochondria: Improving hydroxybenzoic acids antioxidant properties". Paper presented in 49th Annual Scientific Meeting of the European Society for Clinical Investigation. Cluj-Napoca, Romania., 2015.
  27. Silva, T. "Neuroprotective Properties of Lipophilic Antioxidants Based on Hydroxycinnamic Acid Template". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho. Braga, Portugal., 2015.
  28. Silva, T. "Development of arylnitrone hybrids endowed with neuroprotective and cholinesterase inhibitory activities". Paper presented in 22nd Young Research Fellow Meeting. Paris, France., 2015.
  29. Silva, T. "5-Nitrocaffeic acid and derivatives thereof inhibit tau-derived-hexapeptide 306VQIVYK311 aggregation and catechol O-methyltransferase activity". Paper presented in 22nd Young Research Fellow Meeting. Paris, France., 2015.
  30. Silva, T. "Development of neuroprotective antioxidants: in vitro and cellular activity of lipophilic cinnamic acid derivatives". Paper presented in 50th Congress of the European Societies of Toxicology. Edinburgh, United Kingdom., 2014.
  31. Silva, T. "Development of novel cinnamoyl-piperazine derivatives endowed with antioxidant-anticholinesterase activity". Paper presented in 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  32. Silva, T. "Discovery of new leads for old targets: insights on the lead optimization process of a new MAO-B inhibitor based on chromone scaffold". Paper presented in 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  33. Silva, T. "Development of novel multi-functional nitrones as neuroprotective agents". Paper presented in 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  34. Silva, T. "Development of centrally active multi-target directed cinnamic acid derivatives for neurodegenerative diseases". Paper presented in XXXIII European School of Medicinal Chemistry. Urbino, Italy., 2013.
  35. Silva, T. "Design and synthesis of novel antioxidants based on natural scaffolds". Paper presented in VI Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2013.
  36. Silva, T. "Development of Smart Carriers For Delivering Menadione to Mitochondria". Paper presented in VI Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2013.
  37. Silva, T. "Overcoming pharmacokinetic problems associated with antioxidant therapy: development of lipophilic derivatives based on natural hydroxycinnamic acids". Paper presented in 16th Biennial meeting for the Society for Free Radical Research International (SFFRI). London, United Kingdom., 2012.
  38. Silva, T. "Exploring natural profits: development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Paper presented in 16th Biennial meeting for the Society for Free Radical Research International (SFFRI). London, United Kingdom., 2012.
  39. Silva, T. "New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants". Paper presented in EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. Berlin, Germany., 2012.
  40. Silva, T. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Paper presented in EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. Berlin, Germany., 2012.
  41. Silva, T. "Modulating the pharmacokinetic profile of natural phenolic antioxidants with potential neuroprotective activity". Paper presented in 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs, New York, EUA, February 12th-14th, 2012, 2012.
  42. Silva, T. "Jousting neurodegenerative diseases using novel lipophilic antioxidants based on ferulic and caffeic acid". Paper presented in V Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2012.
  43. Silva, T. "New therapeutic approaches towards neurodegenerative diseases: targeting oxidative damage with innovative lipophilic antioxidants". Paper presented in 16th RSC_SCI Cambridge Medicinal Chemistry Symposium. Cambridge, United Kingdom., 2011.
  44. Silva, T. "Benzo-¿-pyrone based ligands as a privileged scaffold for drug discovery: synthesis and structure-affinity relationships for adenosines receptors". Paper presented in 16th RSC_SCI Cambridge Medicinal Chemistry Symposium. Cambridge, United Kingdom., 2011.
  45. Silva, T. "Chromone-based adenosine receptor ligands: a new challenge in the anticancer drug discovery scenario". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry. Porto, Portugal., 2011.
  46. Silva, T. "Development of novel lipophilic antioxidants based on ferulic acid". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry. Porto, Portugal., 2011.
  47. Silva, T. "Pace V, Silva T, Sinisterra JV, Alcántara AR, Hoyos P “Dynamic kinetic asymetric transformations of 1,2-diarylethane-1,2-diols: synthesis of enantiomerically pure benzoins”". Paper presented in Biospain Biotec. Pamplona, Spain., 2010.
  48. Silva, T. "miRNAs: Oncogenes ou Supressores Tumorais?". Paper presented in I Conferência Microbiologia e Biologia do Cancro. Porto, Portugal., 2009.
  49. Silva, T. "Chromone-Based Adenosine Ligands as a New Challenge in Drug Development for the treatment of Neurological Disorders: the Story so far". Paper presented in Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies. Barcelona, Spain., 2009.
  50. Silva, T. "Targeting Cinnamic Antioxidants to Mitochondria: a New Therapeutic Direction on Neurodegenerative Diseases". Paper presented in Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies. Barcelona, Spain., 2009.
  51. Silva, T. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Paper presented in 3rd Joint Italian–German Purine Club Meeting Purinergic Receptors: New Frontiers for Novel Therapies. Camerino, Italy., 2009.
  52. Silva, T. "New therapeutic approaches in cancer: development of novel A3AR antagonists". Paper presented in II Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2009.
Journal article
  1. Pachòn Angona, Irene; Daniel, Solene; Martin, Helene; Bonet, Alexandre; Wnorowski, Artur; Maj, Maciej; Józwiak, Krzysztof; et al. "Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels". Molecules 25 6 (2020): 1329. http://dx.doi.org/10.3390/molecules25061329.
    10.3390/molecules25061329
  2. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Silva, Catia; Gil-Martins, Eva; Soares, Pedro; Silva, Tiago; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry 185 (2020): 111770. http://dx.doi.org/10.1016/j.ejmech.2019.111770.
    10.1016/j.ejmech.2019.111770
  3. Silva, T. "Caffeic Acid Alkyl Amide Derivatives Ameliorate Oxidative Stress and Modulate ERK1/2 and AKT Signaling Pathways in a Rat Model of Diabetic Retinopathy.". Chemistry & biodiversity (2019): https://doi.org/10.1002/cbdv.201900405.
    10.1002/cbdv.201900405
  4. Silva, T. "Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues.". Molecules (Basel, Switzerland) (2019): http://europepmc.org/articles/PMC6930627.
    10.3390/molecules24234405
  5. Silva, T. "Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid.". Organic & biomolecular chemistry (2019): https://doi.org/10.1039/c9ob01875a.
    10.1039/c9ob01875a
  6. Silva, T. "Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.04.026.
    10.1016/j.ejmech.2019.04.026
  7. Silva, T. "Repurposing nitrocatechols: 5-Nitro-a-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.02.006.
    10.1016/j.ejmech.2019.02.006
  8. Silva, T. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors.". European journal of pharmacology (2019): https://doi.org/10.1016/j.ejphar.2019.01.027.
    10.1016/j.ejphar.2019.01.027
  9. Hosseini, R.; Moosavi, F.; Silva, T.; Rajaian, H.; Hosseini, S.Y.; Bina, S.; Saso, L.; et al. "Modulation of ERK1/2 and Akt pathways involved in the neurotrophic action of caffeic acid alkyl esters". Molecules 23 12 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058902543&partnerID=MN8TOARS.
    10.3390/molecules23123340
  10. Oliveira, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Sequeira, L.; Mesiti, F.; Silva, T.; et al. "Hydroxybenzoic acid derivatives as dual-target ligands: Mitochondriotropic antioxidants and cholinesterase inhibitors". Frontiers in Chemistry 6 APR (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047482686&partnerID=MN8TOARS.
    10.3389/fchem.2018.00126
  11. Oliveira, C.; Benfeito, S.; Fernandes, C.; Cagide, F.; Silva, T.; Borges, F.. "NO and HNO donors, nitrones, and nitroxides: Past, present, and future". Medicinal Research Reviews 38 4 (2018): 1159-1187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048825299&partnerID=MN8TOARS.
    10.1002/med.21461
  12. Garrido, E.M.P.J.; Cerqueira, A.S.; Chavarria, D.; Silva, T.; Borges, F.; Garrido, J.M.P.J.. "Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-ß-cyclodextrin". Food Chemistry 254 (2018): 260-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041498708&partnerID=MN8TOARS.
    10.1016/j.foodchem.2018.02.007
  13. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Correction to: Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors (Journal of Medicinal Chemistry (2016) 59 (5879-5893) DOI: 10.1021/acs.jmedchem.6b00527)". Journal of Medicinal Chemistry 61 11 (2018): 5054-5054. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048642711&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.8b00600
  14. Fonseca, A.; Reis, J.; Silva, T.; Matos, M.J.; Bagetta, D.; Ortuso, F.; Alcaro, S.; Uriarte, E.; Borges, F.. "Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?". Journal of Medicinal Chemistry 60 16 (2017): 7206-7212. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028609344&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00918
  15. Moosavi, F.; Hosseini, R.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Saso, L.; Edraki, N.; et al. "Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents". Bioorganic and Medicinal Chemistry 25 12 (2017): 3235-3246. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019013493&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.026
  16. Menezes, J.C.J.M.D.S.; Edraki, N.; Kamat, S.P.; Khoshneviszadeh, M.; Kayani, Z.; Mirzaei, H.H.; Miri, R.; et al. "Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells". Journal of Agricultural and Food Chemistry 65 33 (2017): 7228-7239. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028064983&partnerID=MN8TOARS.
    10.1021/acs.jafc.7b01388
  17. Silva, T.; Mohamed, T.; Shakeri, A.; Rao, P.P.N.; Martínez-Gonzalez, L.; Pérez, D.I.; Martínez, A.; et al. "Development of blood-brain barrier permeable nitrocatechol-based catechol O-methyltransferase inhibitors with reduced potential for hepatotoxicity". Journal of Medicinal Chemistry 59 16 (2016): 7584-7597. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983673507&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b00666
  18. Chavarria, D.; Silva, T.; MagalhãesE Silva, D.; Remiaõ, F.; Borges, F.. "Lessons from black pepper: Piperine and derivatives thereof". Expert Opinion on Therapeutic Patents 26 2 (2016): 245-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957437698&partnerID=MN8TOARS.
    10.1517/13543776.2016.1118057
  19. Hosseini, R.; Moosavi, F.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Soares, P.; Saso, L.; et al. "Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold". Chemical Biology and Drug Design 88 6 (2016): 926-937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987597648&partnerID=MN8TOARS.
    10.1111/cbdd.12829
  20. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975871993&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b00527
  21. Silva, T.; Bravo, J.; Summavielle, T.; Remião, F.; Pérez, C.; Gil, C.; Martínez, A.; Borges, F.. "Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity". RSC Advances 5 21 (2015): 15800-15811. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922828018&partnerID=MN8TOARS.
    10.1039/c4ra15164j
  22. Chavarria, D.; Silva, T.; Martins, D.; Bravo, J.; Summavielle, T.; Garrido, J.; Borges, F.. "Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants". MedChemComm 6 6 (2015): 1043-1053. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935895324&partnerID=MN8TOARS.
    10.1039/c5md00018a
  23. Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry". Chemical Communications 51 14 (2015): 2832-2835. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922432422&partnerID=MN8TOARS.
    10.1039/c4cc08798d
  24. Roleira, F.M.F.; Tavares-Da-Silva, E.J.; Varela, C.L.; Costa, S.C.; Silva, T.; Garrido, J.; Borges, F.. "Plant derived and dietary phenolic antioxidants: Anticancer properties". Food Chemistry 183 (2015): 235-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925860642&partnerID=MN8TOARS.
    10.1016/j.foodchem.2015.03.039
  25. Silva, T.; Borges, F.; Edraki, N.; Alizadeh, M.; Miri, R.; Saso, L.; Firuzi, O.. "Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors". RSC Advances 5 72 (2015): 58902-58911. http://dx.doi.org/10.1039/c5ra08692b.
    10.1039/c5ra08692b
  26. Silva, T. "Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes". Ageing Research Reviews 2014;15:116-45. (2014):
    10.1016/j.arr.2014.03.008
  27. Silva, T.; Oliveira, C.; Borges, F.. "Caffeic acid derivatives, analogs and applications: A patent review (2009-2013)". Expert Opinion on Therapeutic Patents 24 11 (2014): 1257-1270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911478108&partnerID=MN8TOARS.
    10.1517/13543776.2014.959492
  28. Benfeito, S.; Silva, T.; Garrido, J.; Andrade, P.B.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Effects of chlorophenoxy herbicides and their main transformation products on dna damage and acetylcholinesterase activity". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899555466&partnerID=MN8TOARS.
    10.1155/2014/709036
  29. Mura, F.; Silva, T.; Castro, C.; Borges, F.; Zuñiga, M.C.; Morales, J.; Olea-Azar, C.. "New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: Spectroscopic, electrochemistry, and cellular studies". Free Radical Research 48 12 (2014): 1473-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908670344&partnerID=MN8TOARS.
    10.3109/10715762.2014.965702
  30. Silva, T. "Antioxidant therapy: still in search of the 'magic bullet'.". Mitochondrion. 2013;13(5):427-35. (2013):
    10.1016/j.mito.2012.12.002
  31. Silva, T. "Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry. 2013;62:289-96 (2013):
    10.1016/j.ejmech.2012.12.049
  32. Silva, T.; Teixeira, J.; Remião, F.; Borges, F.. "Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways". Angewandte Chemie - International Edition 52 4 (2013): 1110-1121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872382364&partnerID=MN8TOARS.
    10.1002/anie.201204964
  33. Teixeira, J.; Silva, T.; Andrade, P.B.; Borges, F.. "Alzheimer's disease and antioxidant therapy: How long how far?". Current Medicinal Chemistry 20 24 (2013): 2939-2952. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880283997&partnerID=MN8TOARS.
    10.2174/1871523011320240001
  34. Silva, T. "Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.". Journal of Medicinal Chemistry. 2011;54(14):5165-73. (2011):
    10.1021/jm2004267
  35. Silva, T. "Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells.". Chemical Research in Toxicology. 2011;24(5):763-74 (2011):
    10.1021/tx200126r
  36. Gaspar, A.; Silva, T.; Borges, F.. "Adenosine a3 receptors: A new therapeutic approach in cancer,Receptores a3 da adenosina: uma nova abordagem terapêutica no câncer". Quimica Nova 34 8 (2011): 1417-1424. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054893720&partnerID=MN8TOARS.
    10.1590/S0100-40422011000800022
Thesis / Dissertation
  1. Silva, T. "Hidroxycinnamic Acid, a Valid Scaffold for the Development of CNS Multitarget Drugs. Synthesis, Pharmacological and Toxicological Studies.". PhD, 2016. https://repositorio-aberto.up.pt/handle/10216/98916.
  2. Silva, T. "Colesterol e estatinas na doença de Alzheimer". Master, 2010. http://catalogo.up.pt/F/?func=direct&doc_number=000137919&local_base=ICBFF.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/07/18 T. Silva “Derisking nitrocatechols: Development of non-hepatotoxic inhibitors of catechol O-methyltransferase” Palestras DQB (FCUP)
(Porto, Portugal)
2018/07/12 C. Oliveira, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, S. Vilar, E. Uriarte, P. J. Oliveira, F. Borges “Benzoic acid as a valid scaffold for the development of dual-target directed drugs for Alzheimer’s disease” VIII Meeting of the Paul Ehrlich Euro-PhD Network
(Porto, Portugal)
2018/03/15 C. Oliveira*, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, S. Vilar, E. Uriarte, P. J. Oliveira, F. Borges “Development of multi-target agents based on hydroxybenzoic acid scaffold endowed with mitochondriotropic antioxidant and cholinesterase inhibitory activities” 2nd WG meeting – Status of WG activities of the MuTaLig COST Action
(Tenerife, Spain)
2018/02/23 F. Mesiti, A. Gaspar, D. Chavarria, T. Silva, S. Alcaro, F. Borges “Design and development of new chemical entities for the treatment of Parkinson disease” 3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135)
(Porto, Portugal)
2017/08/25 C. Oliveira, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, E. Uriarte, P. J. Oliveira, F. Borges “Development of hybrid antioxidant and cholinesterase agents for Alzheimer’s disease” VII Meeting of the Paul Ehrlich Euro-PhD Network
(Vienna, Austria)
2017/05/17 V. A. Sardão, T. Silva, R. F. Simões, P. J. Oliveira, C. D. Veloso, M. J. Valente, R. Silva, F. Remião, F. Borges “Promising new catechol O-methyltransferase (COMT) inhibitors for Parkinson's disease display lower mitochondrial toxicity” 51st Annual Scientific Meeting of the European Society for Clinical Investigation
(Genoa, Italy)
2016/11/18 T. Silva, J. Garrido, F. Remião, P. Oliveira, F. Borges “Hydroxycinnamic acid as a valid scaffold for the development of CNS multitarget drugs” 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept
(Budapest, Hungary)
2016/07/21 T. Silva, P. Rao, P. Soares da Silva, A. Martínez, F. Remião, J. Garrido, P. Oliveira, F. Borges “Hydroxycinnamic acid as a valid scaffold for the development of multitarget ligands for CNS disorders” 1st annual meeting – MuTaLig COST Action – Università della Svizzera Italiana
(Lugano, Switzerland)
2016/03/18 M.D. Magalhães-e-Silva*, R. Hosseini, F. Moosavi, T. Silva, H. Rajaeian, P. Soares, L. Saso, O. Firuzi, F. Borges, “Síntese e caracterização de fatores neurotróficos baseado em compostos fenólicos” 4º Encontro Nacional de Estudantes de Química (ENEQUI)
2015/12/01 D. Magalhães-e-Silva*, R. Hosseini, F. Moosavi, T. Silva, H. Rajaeian, P. Soares, L. Saso, O. Firuzi, F.Borges “Development of neurotrophic agents based on hydroxycinnamic acid scaffold” 11º Encontro Nacional de Química Orgânica / 4º Encontro de Química Terapêutica
(Porto, Portugal)
2015/09/28 T. Silva, F. Borges “Hydroxycinnamic acids: a valid scaffold in Medicinal Chemistry” COST-EPIGEN MEETING
(Budapest, Hungary)
2015/07/03 D. Chavarria, T. Silva, T. Summavielle, F. Borges “Development of novel neuroprotective antioxidants inspired on hydroxycinnamic acid scaffold” V Meeting of the Paul Ehrlich Euro-PhD Network
(Cracow, Poland)
2015/07/03 T. Silva*, M. Mohamed, P.P.N. Rao, A. Martínez, P. Soares-da-Silva, F. Remião, F. Borges, “5-Nitrocaffeic acid derivatives as multifunctional agents for neurodegenerative diseases” V Meeting of the Paul Ehrlich Euro-PhD Network
(Cracow, Poland)
2015/07/03 J. Teixeira, C. Oliveira, R. Amorim, T. Silva, F. Cagide, J. Garrido, P. B. Andrade, P. J. Oliveira, F. Borges “Targeting dietary hydroxybenzoic acids to mitochondria: A refined strategy to improve Nature” V Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cracow, Poland)
2015/07/02 F. Borges, T. Silva, J. Teixeira, F. Cagide, D. Chavarria, D. Magalhães-e-Silva, S. Benfeito*, C. Fernandes, C. Oliveira “Antioxidants: from Nature to drug prototypes” International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress"
(Rome, Italy)
2015/05/27 J. Teixeira*, C. Oliveira, R. Amorim, T. Silva, F. Cagide, J. Garrido, P. J. Oliveira, P.B. Andrade, F. Borges “Targeting dietary phenolic acids to mitochondria: Improving hydroxybenzoic acids antioxidant properties” 49th Annual Scientific Meeting of the European Society for Clinical Investigation
(Cluj-Napoca, Romania)
2015/05/13 D. Chavarria, T. Silva, J. Bravo, T. Summavielle, F. Borges. “Exploring Cinnamic Acid Scaffold: Development of Promising Neuroprotective Lipophilic Antioxidants.” VIII Encontro de Jovens Investigadores da UP (IJUP)
(Porto, Portugal)
2015/03/27 D. Magalhães-e-Silva, D. Chavarria, T. Silva, F. Borges. “Finding a therapeutic solution for neurodegenerative diseases: design and synthesis of novel neuroprotective agents.” III ENEQUI – “Ilumina o teu conhecimento!"
(Aveiro, Portugal)
2014/06/05 T. Silva, D. Chavarria, L. Sequeira, J. Garrido, T. Summavielle, F. Borges “Biology-oriented Development of Novel Lipophilic Antioxidants With Neuroprotective Activity” World Congress on Polyphenols Applications: ISANH Polyphenols 2014
(Lisbon, Portugal)
2013/09/27 T. Silva*, L. Sequeira, A. Martínez, F. Borges “Towards the development of multi-target directed drugs for neurodegenerative diseases based on the natural cinnamic acid scaffold” 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cagliari, Italy)
2013/09/27 T. Silva, L. Sequeira, A. Martínez, F. Borges "Towards the development of multi-target directed drugs for neurodegenerative diseases based on the natural cinnamic acid scaffold" 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cagliari)
2013/02/13 R. P. Matos, T. Silva, P. Valentão, A. P. Oliveira, F. Borges, E. Benfeito, A. Oliveira, S. Meireles, T. M. Brandão, P. B. Andrade «Spergularia rubra: A functional beverage to reduce overweight, obesity and diabetes» IJUP13–6º Encontro de Jovens Investigadores da U. Porto
(Porto, Portugal)
2013/01/09 T. Silva, I. Encarnação, J. Amorim, L. Sequeira, A. Gaspar, J. Garrido, F. Borges «Bridging the gap between nature and phenolic antioxidants» 2nd Workshop on Medicinal Chemistry
(Porto, Portugal)
2011/11/10 T. Silva, A. Gaspar, J. Teixeira, N. Leal, F. Borges, J. Garrido «New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants» 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Rome, Italy)
2011/11/10 F. Borges*, A. Gaspar, T. Silva, J. Teixeira, F. Cagide, S. Benfeito, C. Oliveira, J. Reis, M. Garrido, J. Garrido, O. Firuzi, L. Saso «Striving for success in antioxidant therapy» 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Rome, Italy)
2011/10/20 F. Borges, A. Gaspar, J. Garrido, E. M. Garrido, T. Silva, J. Reis, F. Cagide, N. Milhazes, O. Firuzi, L. Saso «Antioxidant therapy: in search of the magic bullet» 2nd World Congress on Targeting Mitochondria–Berlin, Germany, October 20th-21st, 2011
World Mitochondria Society (Berlin, Germany)
2009/12/11 T. Silva, T. Silveira «Como Ocorre a Imortalização Celular no Cancro?» I Conferência Microbiologia e Biologia do Cancro
Faculty of Pharmacy, University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - Current Desenvolvimento de novos antioxidantes e quelantes de ferro para o tratamento da doença de Alzheimer
Co-supervisor
 Chemistry (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2017 - Current Synthesis of piperazine derivatives as acetylholinesterase inhibitors as a potential treatment of Alzheimer's disease
Co-supervisor
 Biochemistry (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - Current Desenvolvimento de novos sistemas híbridos cinâmico-colina como estratégia terapêutica para a doença de Alzheimer
Supervisor
 Biochemistry (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - Current Extracurricular internship (PEEC program), training in organic synthesis
Co-supervisor
 Biochemistry (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - Current Extracurricular internship program, training in organic synthesis
Co-supervisor
 Biochemistry (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - Current Extracurricular internship program, training in organic synthesis
Co-supervisor
 Biochemistry (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/07/12 - Current VIII Meeting of the Paul Ehrlich Euro-PhD Network (2018/07/12)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2014/05/30 - Current Third workshop in Medicinal Chemistry. Drug Discovery and Development: Understanding the R&D Process (2014/06/30)
Workshop (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2013/01/13 - Current Second workshop in Medicinal Chemistry. Drug Discovery and Development: Understanding the R&D Process Role: Member of the Organizing Committee (2013/01/13)
Workshop (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - Current Second Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2010/05/23 - Current Doença cardiovascular: uma velha temática, uma nova abordagem (2010/05/23)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019 Design de nanopartículas PEGuiladas de PLGA para diminuição do perfil hepatotóxico da tolcapona
(Thesis) Main arguer
 Carlos Soares (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Development of Novel Lipophilic Antioxidants as a Therapeutic Solution for Neurodegenerative
(Thesis) Main arguer
 João Lourenço (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2018 Design and development of multi-target agents for neurodegenerative diseases Ester Sofia Benfeito (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 Development of new monoamine oxidase (MAO-B) inhibitors based on chromone as potential drugs for the treatment of Parkinson disease
(Thesis) Main arguer
 Cláudia Tomé (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2016 Desenvolvimento de novos antioxidantes tendo como base modelos naturais
(Thesis) Main arguer
 Brandon Aguiar (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2020/01 - Current PT-OPENSCREEN: National Infrastructure for Chemical Biology Compound provider and hit-to-lead optimization

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019 - Current Bioorganic Chemistry (Mestrado)
2017 - Current Biological Chemistry (Licenciatura)
2016 - Current Medicinal Chemistry (Mestrado)

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2013 Article on the importance of cholesterol in Alzheimer's disease.

Journal scientific committee

Journal title (ISSN) Publisher
2019 - Current Molecules (1420-3049) MDPI AG

Mentoring / Tutoring

Topic Student name
2019 - Current Synthesis of new antioxidants Taha Koulani
2018 - Current Synthesis of bifunctional derivatives of kojic acid and deferiprone Francesca Cantisani
2018 - Current Screening of new hMAO-B inhibitors Paolo Guglielmi
2014 - Current Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para as Doenças Neurodegenerativas Daniel Chavarria
2014 - Current Synthesis of 4-aryl derivatives of ferulic acid Francisco Mura
2013 - Current Desenvolvimento de Novos Antioxidantes Lipofílicos Baseados em Modelos de Origem Natural Lisa Sequeira
Distinctions

Award

2016 Award of the Paul Ehrlich MedChem Euro-PhD Certificate
2013 EFMC Full grant to attend the XXXIII European School of Medicinal Chemistry (EU)
2012 ADDF Young Investigator Scholarship
Alzheimer's Drug Discovery Foundation, United States

Other distinction

2019 Full grant, CA15135 Multi-Targeting Biophysical Training School, 2nd edition (EU)
2018 Invited Researcher Grant, DTU Chemistry (DK)
2016 CCRN Post-Doctoral Fellowship CIQ-SAM/BIOANTIOX-BPD2 (PT)
2016 FCT Post-Doctoral Fellowship SFRH/BPD/114945/2016 (PT)
2011 Project Research Grant PTDC/QUI-QUI/113687/2009 (PT)
2011 FCT PhD Grant SFRH/BD/79671/2011 (PT)
2010 Erasmus Research Undergraduate Fellowship (EU)