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Tiago Barros Silva obtained his MSc in Pharmaceutical Sciences (2010) and PhD in Pharmaceutical Sciences (2016) from the Faculty of Pharmacy of the University of Porto. He has since worked as a postdoc in collaboration with three different research groups: the MedChem group led by F. Borges (CIQ/FCUP, Porto PT), MitoXT group led by P.J. Oliveira (Biocant/UC, Coimbra PT) and the KAS group led by K. Astakhova (DTU Chem, Copenhagen DK), developing projects in small molecule drug design, toxicology and nanotherapeutics. He is currently working on the development of smart dual-acting dopamine-enhacing inhibitors of ferroptosis for neurological disorders associated with dopamine depletion.
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Identificação

Identificação pessoal

Nome completo
Nuno Tiago Barros Silva

Nomes de citação

  • Silva, T

Identificadores de autor

Ciência ID
5B11-6B6D-036B
ORCID iD
0000-0003-0874-5982
Google Scholar ID
Tiago Barros Silva
Scopus Author Id
25641749600

Endereços de correio eletrónico

  • nuno.silva@fc.up.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Alemão Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2016
Concluído
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Hydroxycinnamic acid, a valid scaffold for the development of CNS multitarget drugs. Synthesis, pharmacological and toxicological studies." (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade com distinção
2010
Concluído
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Colesterol e Estatinas na Doença de Alzheimer." (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/06/01 - Atual Pós-doutorado (Investigação) CNC.IBILI, Portugal
2018/03/01 - 2018/06/15 Investigador visitante (Investigação) Danmarks Tekniske Universitet, Dinamarca
2016/07/15 - 2017/05/31 Pós-doutorado (Investigação) Universidade do Porto Centro de Investigação em Química, Portugal
2010/02/01 - 2010/06/01 Estagiário de Investigação (Investigação) Universidad Complutense de Madrid Facultad de Farmacia, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/04/01 - 2016/04/01 PhD student, FCT Grant (SFRH /BD/79671/2011) Universidade do Porto Faculdade de Farmácia, Portugal
2011/03/15 - 2012/03/15 Research Grant, BP4BRAIN project (PTDC/QUI-QUI/113687/2009) Universidade do Porto Centro de Investigação em Química, Portugal
2010/06/01 - 2010/09/01 Pharmacy intern Farmácia Firmeza, Portugal
Projetos

Bolsa

Designação Financiadores
2016/07/15 - 2017/06/30 SAM: Sustained Advanced Materials (NORTE-01-0145-FEDER-000028)
CIQ-SAM/BIOANTIOX-BPD2
Bolseiro de Pós-Doutoramento
Universidade do Porto Centro de Investigação em Química, Portugal
Em curso
2011/03/15 - 2012/03/15 BP4Brain – Benzopirano: uma estrutura priveligiada para o desenho racional de compostos multi-alvo com aplicação potencial em doenças neurodegenerativas
PTDC/QUI-QUI/113687/2009
Bolseiro de Investigação
Universidade do Porto Centro de Investigação em Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2019/05/22 - Atual COMT4BRAIN: Development of centrally-active and safe catechol O-methyltransferase inhibitors
POCI-01-0145-FEDER-029164
Bolseiro de Pós-Doutoramento
Universidade do Porto Centro de Investigação em Química, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Em curso
2016/10/01 - Atual MitoBOOST - MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria
PTDC/DTP-FTO/2433/2014
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. Pachòn Angona, Irene; Daniel, Solene; Martin, Helene; Bonet, Alexandre; Wnorowski, Artur; Maj, Maciej; Józwiak, Krzysztof; et al. "Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels". Molecules 25 6 (2020): 1329. http://dx.doi.org/10.3390/molecules25061329.
    10.3390/molecules25061329
  2. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Silva, Catia; Gil-Martins, Eva; Soares, Pedro; Silva, Tiago; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry 185 (2020): 111770. http://dx.doi.org/10.1016/j.ejmech.2019.111770.
    10.1016/j.ejmech.2019.111770
  3. Silva, T. "Caffeic Acid Alkyl Amide Derivatives Ameliorate Oxidative Stress and Modulate ERK1/2 and AKT Signaling Pathways in a Rat Model of Diabetic Retinopathy.". Chemistry & biodiversity (2019): https://doi.org/10.1002/cbdv.201900405.
    10.1002/cbdv.201900405
  4. Silva, T. "Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues.". Molecules (Basel, Switzerland) (2019): http://europepmc.org/articles/PMC6930627.
    10.3390/molecules24234405
  5. Silva, T. "Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid.". Organic & biomolecular chemistry (2019): https://doi.org/10.1039/c9ob01875a.
    10.1039/c9ob01875a
  6. Silva, T. "Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.04.026.
    10.1016/j.ejmech.2019.04.026
  7. Silva, T. "Repurposing nitrocatechols: 5-Nitro-a-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.". European journal of medicinal chemistry (2019): https://doi.org/10.1016/j.ejmech.2019.02.006.
    10.1016/j.ejmech.2019.02.006
  8. Silva, T. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors.". European journal of pharmacology (2019): https://doi.org/10.1016/j.ejphar.2019.01.027.
    10.1016/j.ejphar.2019.01.027
  9. Hosseini, R.; Moosavi, F.; Silva, T.; Rajaian, H.; Hosseini, S.Y.; Bina, S.; Saso, L.; et al. "Modulation of ERK1/2 and Akt pathways involved in the neurotrophic action of caffeic acid alkyl esters". Molecules 23 12 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058902543&partnerID=MN8TOARS.
    10.3390/molecules23123340
  10. Oliveira, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Sequeira, L.; Mesiti, F.; Silva, T.; et al. "Hydroxybenzoic acid derivatives as dual-target ligands: Mitochondriotropic antioxidants and cholinesterase inhibitors". Frontiers in Chemistry 6 APR (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047482686&partnerID=MN8TOARS.
    10.3389/fchem.2018.00126
  11. Oliveira, C.; Benfeito, S.; Fernandes, C.; Cagide, F.; Silva, T.; Borges, F.. "NO and HNO donors, nitrones, and nitroxides: Past, present, and future". Medicinal Research Reviews 38 4 (2018): 1159-1187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048825299&partnerID=MN8TOARS.
    10.1002/med.21461
  12. Garrido, E.M.P.J.; Cerqueira, A.S.; Chavarria, D.; Silva, T.; Borges, F.; Garrido, J.M.P.J.. "Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-ß-cyclodextrin". Food Chemistry 254 (2018): 260-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041498708&partnerID=MN8TOARS.
    10.1016/j.foodchem.2018.02.007
  13. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Correction to: Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors (Journal of Medicinal Chemistry (2016) 59 (5879-5893) DOI: 10.1021/acs.jmedchem.6b00527)". Journal of Medicinal Chemistry 61 11 (2018): 5054-5054. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048642711&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.8b00600
  14. Fonseca, A.; Reis, J.; Silva, T.; Matos, M.J.; Bagetta, D.; Ortuso, F.; Alcaro, S.; Uriarte, E.; Borges, F.. "Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?". Journal of Medicinal Chemistry 60 16 (2017): 7206-7212. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028609344&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.7b00918
  15. Moosavi, F.; Hosseini, R.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Saso, L.; Edraki, N.; et al. "Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents". Bioorganic and Medicinal Chemistry 25 12 (2017): 3235-3246. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019013493&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.026
  16. Menezes, J.C.J.M.D.S.; Edraki, N.; Kamat, S.P.; Khoshneviszadeh, M.; Kayani, Z.; Mirzaei, H.H.; Miri, R.; et al. "Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells". Journal of Agricultural and Food Chemistry 65 33 (2017): 7228-7239. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028064983&partnerID=MN8TOARS.
    10.1021/acs.jafc.7b01388
  17. Silva, T.; Mohamed, T.; Shakeri, A.; Rao, P.P.N.; Martínez-Gonzalez, L.; Pérez, D.I.; Martínez, A.; et al. "Development of blood-brain barrier permeable nitrocatechol-based catechol O-methyltransferase inhibitors with reduced potential for hepatotoxicity". Journal of Medicinal Chemistry 59 16 (2016): 7584-7597. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983673507&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b00666
  18. Chavarria, D.; Silva, T.; MagalhãesE Silva, D.; Remiaõ, F.; Borges, F.. "Lessons from black pepper: Piperine and derivatives thereof". Expert Opinion on Therapeutic Patents 26 2 (2016): 245-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957437698&partnerID=MN8TOARS.
    10.1517/13543776.2016.1118057
  19. Hosseini, R.; Moosavi, F.; Rajaian, H.; Silva, T.; Magalhães e Silva, D.; Soares, P.; Saso, L.; et al. "Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold". Chemical Biology and Drug Design 88 6 (2016): 926-937. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987597648&partnerID=MN8TOARS.
    10.1111/cbdd.12829
  20. Reis, J.; Cagide, F.; Chavarria, D.; Silva, T.; Fernandes, C.; Gaspar, A.; Uriarte, E.; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975871993&partnerID=MN8TOARS.
    10.1021/acs.jmedchem.6b00527
  21. Silva, T.; Bravo, J.; Summavielle, T.; Remião, F.; Pérez, C.; Gil, C.; Martínez, A.; Borges, F.. "Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity". RSC Advances 5 21 (2015): 15800-15811. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922828018&partnerID=MN8TOARS.
    10.1039/c4ra15164j
  22. Chavarria, D.; Silva, T.; Martins, D.; Bravo, J.; Summavielle, T.; Garrido, J.; Borges, F.. "Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants". MedChemComm 6 6 (2015): 1043-1053. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935895324&partnerID=MN8TOARS.
    10.1039/c5md00018a
  23. Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L.R.; Low, J.N.. "Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry". Chemical Communications 51 14 (2015): 2832-2835. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922432422&partnerID=MN8TOARS.
    10.1039/c4cc08798d
  24. Roleira, F.M.F.; Tavares-Da-Silva, E.J.; Varela, C.L.; Costa, S.C.; Silva, T.; Garrido, J.; Borges, F.. "Plant derived and dietary phenolic antioxidants: Anticancer properties". Food Chemistry 183 (2015): 235-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925860642&partnerID=MN8TOARS.
    10.1016/j.foodchem.2015.03.039
  25. Silva, T.; Borges, F.; Edraki, N.; Alizadeh, M.; Miri, R.; Saso, L.; Firuzi, O.. "Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors". RSC Advances 5 72 (2015): 58902-58911. http://dx.doi.org/10.1039/c5ra08692b.
    10.1039/c5ra08692b
  26. Silva, T. "Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes". Ageing Research Reviews 2014;15:116-45. (2014):
    10.1016/j.arr.2014.03.008
  27. Silva, T.; Oliveira, C.; Borges, F.. "Caffeic acid derivatives, analogs and applications: A patent review (2009-2013)". Expert Opinion on Therapeutic Patents 24 11 (2014): 1257-1270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911478108&partnerID=MN8TOARS.
    10.1517/13543776.2014.959492
  28. Benfeito, S.; Silva, T.; Garrido, J.; Andrade, P.B.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Effects of chlorophenoxy herbicides and their main transformation products on dna damage and acetylcholinesterase activity". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899555466&partnerID=MN8TOARS.
    10.1155/2014/709036
  29. Mura, F.; Silva, T.; Castro, C.; Borges, F.; Zuñiga, M.C.; Morales, J.; Olea-Azar, C.. "New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: Spectroscopic, electrochemistry, and cellular studies". Free Radical Research 48 12 (2014): 1473-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908670344&partnerID=MN8TOARS.
    10.3109/10715762.2014.965702
  30. Silva, T. "Antioxidant therapy: still in search of the 'magic bullet'.". Mitochondrion. 2013;13(5):427-35. (2013):
    10.1016/j.mito.2012.12.002
  31. Silva, T. "Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry. 2013;62:289-96 (2013):
    10.1016/j.ejmech.2012.12.049
  32. Silva, T.; Teixeira, J.; Remião, F.; Borges, F.. "Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways". Angewandte Chemie - International Edition 52 4 (2013): 1110-1121. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872382364&partnerID=MN8TOARS.
    10.1002/anie.201204964
  33. Teixeira, J.; Silva, T.; Andrade, P.B.; Borges, F.. "Alzheimer's disease and antioxidant therapy: How long how far?". Current Medicinal Chemistry 20 24 (2013): 2939-2952. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880283997&partnerID=MN8TOARS.
    10.2174/1871523011320240001
  34. Silva, T. "Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.". Journal of Medicinal Chemistry. 2011;54(14):5165-73. (2011):
    10.1021/jm2004267
  35. Silva, T. "Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells.". Chemical Research in Toxicology. 2011;24(5):763-74 (2011):
    10.1021/tx200126r
  36. Gaspar, A.; Silva, T.; Borges, F.. "Adenosine a3 receptors: A new therapeutic approach in cancer,Receptores a3 da adenosina: uma nova abordagem terapêutica no câncer". Quimica Nova 34 8 (2011): 1417-1424. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054893720&partnerID=MN8TOARS.
    10.1590/S0100-40422011000800022
Capítulo de livro
  1. Silva, T. "Recycling bromovanillin into ferulic acid-based antioxidants". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 559-563. Royal Chemical Society, 2016.
  2. Silva, T. "Synthesis of lipophilic antioxidants based on natural models". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 380-386. Royal Chemical Society, 2016.
Poster em conferência
  1. Silva, T. "An atypical catechol O-methyltransferase inhibitor is a remarkable modulator of hypoxia in HeLa cells". Trabalho apresentado em MuTaLig COST ACTION CA15135 WG1 Meeting 2020 Izmir (Turkey), 2020.
  2. Silva, T. "Benzoic acid-derived nitrones: a new class of acetylcholinesterase inhibitors and potential neuroprotective agents". Trabalho apresentado em IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting. Catanzaro, Italy., 2019.
  3. Silva, T. "Hydroxypyridin-4-ones are a versatile scaffold to develop copper(II)-chelating COMT inhibitors with neuroprotective properties". Trabalho apresentado em IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting. Catanzaro, Italy., 2019.
  4. Silva, T. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Trabalho apresentado em 26th Young Research Fellows meeting. Paris, France., 2019.
  5. Silva, T. "Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  6. Silva, T. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  7. Silva, T. "Development of Dual Acting COMT Inhibitors and Iron Chelators: Studies on Synthetic Routes Optimization". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST Action (CA15135). Valeta, Malta., 2018.
  8. Silva, T. "Development of Novel Phenolic and Thiophenolic Antioxidants based on Cinnamic Acid Scaffold". Trabalho apresentado em 8th meeting of Paul Ehrlich MedChem EuroPhD Network. Porto, Portugal., 2018.
  9. Silva, T. "Synthesis of Non-Nitrocatechol COMT Inhibitors". Trabalho apresentado em 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, July 12th-14th, 2018, 2018.
  10. Silva, T. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Trabalho apresentado em 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, July 12th-14th, 2018, 2018.
  11. Silva, T. "Hydroxycinnamic acid derivatives and sulfured analogues: from synthesis to antioxidant properties". Trabalho apresentado em 2nd WG meeting – Status of WG activities of the MuTaLig COST Action (CA15135). Tenerife, Spain., 2018.
  12. Silva, T. "Natural products in drug discovery: enhancing the antioxidant profile of hydroxycinnamic acids". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  13. Silva, T. "Microencapsulation as a strategy to improve the ADMET properties of bioactive caffeic acid derivatives". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  14. Silva, T. "Hydroxybenzoic acid-based mitochondriotropic antioxidants as cholinesterase inhibitors". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig (CA15135) COST actions joint meeting. Annual meeting. School of Oncology of the Portuguese, Oncology Institute of Porto (IPO Porto). Porto, Portugal., 2017.
  15. Silva, T. "Design, synthesis and neuroprotective properties of new hydroxycinnamic acid-based antioxidants". Trabalho apresentado em 7th meeting of Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, August 25th-27th, 2017, 2017.
  16. Silva, T. "Effect of the acid strength on the antioxidant profile of natural and synthetic antioxidants". Trabalho apresentado em 37th Edition of the European School of Medicinal Chemistry (ESMEC). Urbino, Italy., 2017.
  17. Silva, T. "Optimizing nature: development of novel antioxidants based on ferulic acid". Trabalho apresentado em 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept. Budapest, Hungary., 2016.
  18. Silva, T. "Insights on the development of novel neuroprotective agents: a comparative study between ferulic acid and related sulfanyl derivatives". Trabalho apresentado em 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept. Budapest, Hungary., 2016.
  19. Silva, T. "In vitro cellular and mitochondrial toxicity and tolcapone and related nitrocatechols". Trabalho apresentado em EUROTOX2016: 52nd European Congress of the European Societies of Toxicology. Seville, Spain., 2016.
  20. Silva, T. "Enhancement of solubility and bioavailability of caffeic acid phenethyl ester using cyclodextrin inclusion complexes". Trabalho apresentado em IX Encontro de Jovens Investigadores da Universidade do Porto. Porto, Portugal., 2016.
  21. Silva, T. "Desenvolvimento de novos agentes neurotróficos baseados no ácido hidroxicinâmico". Trabalho apresentado em I Encontro Científico do Núcleo de Estudantes de Química/Associação Académica de Coimbra (NEQ/AAC). Coimbra, Portugal., 2015.
  22. Silva, T. "Electrochemical and antioxidant activity of diene derivatives inspired on natural hydroxycinnamic acids". Trabalho apresentado em XX Meeting of the Portuguese Electrochemical Society (XXSNSPE). Braga, Portugal., 2015.
  23. Silva, T. "Development of Novel Neuroprotective Antioxidants Inspired on Hydroxycinnamic Acid Scaffold". Trabalho apresentado em V Meeting of the Paul Ehrlich Euro-PhD Network. Krakow, Poland., 2015.
  24. Silva, T. "Development of multitarget-directed nitrocinnamic derivatives endowed with neuroprotective properties". Trabalho apresentado em International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress. Rome, Italy., 2015.
  25. Silva, T. "Development of hybrid arylnitrones antioxidants for ameliorating the oxidative stress associated with Alzheimer disease". Trabalho apresentado em ESMEC 2015 - European School of Medicinal Chemistry (ESMEC), Urbino, Italy, June 28th – July 3rd, 2015, 2015.
  26. Silva, T. "Targeting dietary phenolic acids to mitochondria: Improving hydroxybenzoic acids antioxidant properties". Trabalho apresentado em 49th Annual Scientific Meeting of the European Society for Clinical Investigation. Cluj-Napoca, Romania., 2015.
  27. Silva, T. "Neuroprotective Properties of Lipophilic Antioxidants Based on Hydroxycinnamic Acid Template". Trabalho apresentado em 2nd Symposium on Medicinal Chemistry of University of Minho. Braga, Portugal., 2015.
  28. Silva, T. "Development of arylnitrone hybrids endowed with neuroprotective and cholinesterase inhibitory activities". Trabalho apresentado em 22nd Young Research Fellow Meeting. Paris, France., 2015.
  29. Silva, T. "5-Nitrocaffeic acid and derivatives thereof inhibit tau-derived-hexapeptide 306VQIVYK311 aggregation and catechol O-methyltransferase activity". Trabalho apresentado em 22nd Young Research Fellow Meeting. Paris, France., 2015.
  30. Silva, T. "Development of neuroprotective antioxidants: in vitro and cellular activity of lipophilic cinnamic acid derivatives". Trabalho apresentado em 50th Congress of the European Societies of Toxicology. Edinburgh, United Kingdom., 2014.
  31. Silva, T. "Development of novel cinnamoyl-piperazine derivatives endowed with antioxidant-anticholinesterase activity". Trabalho apresentado em 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  32. Silva, T. "Discovery of new leads for old targets: insights on the lead optimization process of a new MAO-B inhibitor based on chromone scaffold". Trabalho apresentado em 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  33. Silva, T. "Development of novel multi-functional nitrones as neuroprotective agents". Trabalho apresentado em 4th Meeting of the Paul Ehrlich MedChem Euro–PhD Network. Hradec Králové, Czech Republic., 2014.
  34. Silva, T. "Development of centrally active multi-target directed cinnamic acid derivatives for neurodegenerative diseases". Trabalho apresentado em XXXIII European School of Medicinal Chemistry. Urbino, Italy., 2013.
  35. Silva, T. "Design and synthesis of novel antioxidants based on natural scaffolds". Trabalho apresentado em VI Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2013.
  36. Silva, T. "Development of Smart Carriers For Delivering Menadione to Mitochondria". Trabalho apresentado em VI Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2013.
  37. Silva, T. "Overcoming pharmacokinetic problems associated with antioxidant therapy: development of lipophilic derivatives based on natural hydroxycinnamic acids". Trabalho apresentado em 16th Biennial meeting for the Society for Free Radical Research International (SFFRI). London, United Kingdom., 2012.
  38. Silva, T. "Exploring natural profits: development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Trabalho apresentado em 16th Biennial meeting for the Society for Free Radical Research International (SFFRI). London, United Kingdom., 2012.
  39. Silva, T. "New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants". Trabalho apresentado em EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. Berlin, Germany., 2012.
  40. Silva, T. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Trabalho apresentado em EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. Berlin, Germany., 2012.
  41. Silva, T. "Modulating the pharmacokinetic profile of natural phenolic antioxidants with potential neuroprotective activity". Trabalho apresentado em 6th Drug Discovery for Neurodegeneration conference: an Intensive Course on Translating Research into Drugs, New York, EUA, February 12th-14th, 2012, 2012.
  42. Silva, T. "Jousting neurodegenerative diseases using novel lipophilic antioxidants based on ferulic and caffeic acid". Trabalho apresentado em V Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2012.
  43. Silva, T. "New therapeutic approaches towards neurodegenerative diseases: targeting oxidative damage with innovative lipophilic antioxidants". Trabalho apresentado em 16th RSC_SCI Cambridge Medicinal Chemistry Symposium. Cambridge, United Kingdom., 2011.
  44. Silva, T. "Benzo-¿-pyrone based ligands as a privileged scaffold for drug discovery: synthesis and structure-affinity relationships for adenosines receptors". Trabalho apresentado em 16th RSC_SCI Cambridge Medicinal Chemistry Symposium. Cambridge, United Kingdom., 2011.
  45. Silva, T. "Chromone-based adenosine receptor ligands: a new challenge in the anticancer drug discovery scenario". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry. Porto, Portugal., 2011.
  46. Silva, T. "Development of novel lipophilic antioxidants based on ferulic acid". Trabalho apresentado em 2nd Iberic Meeting on Medicinal Chemistry. Porto, Portugal., 2011.
  47. Silva, T. "Pace V, Silva T, Sinisterra JV, Alcántara AR, Hoyos P “Dynamic kinetic asymetric transformations of 1,2-diarylethane-1,2-diols: synthesis of enantiomerically pure benzoins”". Trabalho apresentado em Biospain Biotec. Pamplona, Spain., 2010.
  48. Silva, T. "miRNAs: Oncogenes ou Supressores Tumorais?". Trabalho apresentado em I Conferência Microbiologia e Biologia do Cancro. Porto, Portugal., 2009.
  49. Silva, T. "Chromone-Based Adenosine Ligands as a New Challenge in Drug Development for the treatment of Neurological Disorders: the Story so far". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies. Barcelona, Spain., 2009.
  50. Silva, T. "Targeting Cinnamic Antioxidants to Mitochondria: a New Therapeutic Direction on Neurodegenerative Diseases". Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies. Barcelona, Spain., 2009.
  51. Silva, T. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Trabalho apresentado em 3rd Joint Italian–German Purine Club Meeting Purinergic Receptors: New Frontiers for Novel Therapies. Camerino, Italy., 2009.
  52. Silva, T. "New therapeutic approaches in cancer: development of novel A3AR antagonists". Trabalho apresentado em II Encontro de Jovens Investigadores da UP (IJUP). Porto, Portugal., 2009.
Resumo em conferência
  1. Silva, T. "In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols". Trabalho apresentado em EUROTOX 2016: 52nd Congress of the European Societies of Toxicology. Toxicol. Lett, 2016, 258, S131, Sevilla, 2016.
  2. Silva, T. "Targeting dietary phenolic acids to mitochondria: improving hydroxybenzoic acids antioxidant properties". Trabalho apresentado em 49th Annual Scientific Meeting of the European Society for Clinical Investigation., Cluj-Napoca, 2015.
  3. Silva, T. "Development of neuroprotective antioxidants: In vitro and cellular activity of lipophilic cinnamic acid derivatives". Trabalho apresentado em EUROTOX 2014: 50th Congress of the European Societies of Toxicology. Toxicol Lett 2014, 229, Suppl., S80, Edimburgh, 2014.
    https://doi.org/10.1016/j.toxlet.2014.06.305
  4. Silva, T. "New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants". Trabalho apresentado em EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem 2012, PO21, Berlin, 2012.
  5. Silva, T. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Trabalho apresentado em EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem 2012, PO84, Berlin, 2012.
  6. Silva, T. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Trabalho apresentado em Society for Free Radical Research International 16th Biennial Meeting. Free Rad Biol Med., London, 2012.
  7. Silva, T. "Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif". Trabalho apresentado em Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies” Purinergic Signalling volume 6, pages49–115 (2010), Camerino, 2010.
    doi.org/10.1007/s11302-009-9171-1
  8. Silva, T. "Targeting cinnamic antioxidants to mitochondria: a new therapeutic direction on neurodegenerative diseases". Trabalho apresentado em Frontiers in medicinal chemistry: Emerging targets, novel candidates and innovative strategies., Barcelona, 2009.
  9. Silva, T. "Chromone-based adenosine ligands as a new challenge in drug development for the treatment of neurological disorders: the story so far". Trabalho apresentado em Frontiers in medicinal chemistry: Emerging targets, novel candidates and innovative strategies, Barcelona, 2009.
Tese / Dissertação
  1. Silva, T. "Hidroxycinnamic Acid, a Valid Scaffold for the Development of CNS Multitarget Drugs. Synthesis, Pharmacological and Toxicological Studies.". Doutoramento, 2016. https://repositorio-aberto.up.pt/handle/10216/98916.
  2. Silva, T. "Colesterol e estatinas na doença de Alzheimer". Mestrado, 2010. http://catalogo.up.pt/F/?func=direct&doc_number=000137919&local_base=ICBFF.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/07/18 T. Silva “Derisking nitrocatechols: Development of non-hepatotoxic inhibitors of catechol O-methyltransferase” Palestras DQB (FCUP)
(Porto, Portugal)
2018/07/12 C. Oliveira, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, S. Vilar, E. Uriarte, P. J. Oliveira, F. Borges “Benzoic acid as a valid scaffold for the development of dual-target directed drugs for Alzheimer’s disease” VIII Meeting of the Paul Ehrlich Euro-PhD Network
(Porto, Portugal)
2018/03/15 C. Oliveira*, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, S. Vilar, E. Uriarte, P. J. Oliveira, F. Borges “Development of multi-target agents based on hydroxybenzoic acid scaffold endowed with mitochondriotropic antioxidant and cholinesterase inhibitory activities” 2nd WG meeting – Status of WG activities of the MuTaLig COST Action
(Tenerife, Espanha)
2018/02/23 F. Mesiti, A. Gaspar, D. Chavarria, T. Silva, S. Alcaro, F. Borges “Design and development of new chemical entities for the treatment of Parkinson disease” 3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135)
(Porto, Portugal)
2017/08/25 C. Oliveira, F. Cagide, J. Teixeira, R. Amorim, T. Silva, J. Garrido, F. Remião, E. Uriarte, P. J. Oliveira, F. Borges “Development of hybrid antioxidant and cholinesterase agents for Alzheimer’s disease” VII Meeting of the Paul Ehrlich Euro-PhD Network
(Vienna, Áustria)
2017/05/17 V. A. Sardão, T. Silva, R. F. Simões, P. J. Oliveira, C. D. Veloso, M. J. Valente, R. Silva, F. Remião, F. Borges “Promising new catechol O-methyltransferase (COMT) inhibitors for Parkinson's disease display lower mitochondrial toxicity” 51st Annual Scientific Meeting of the European Society for Clinical Investigation
(Genoa, Itália)
2016/11/18 T. Silva, J. Garrido, F. Remião, P. Oliveira, F. Borges “Hydroxycinnamic acid as a valid scaffold for the development of CNS multitarget drugs” 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept
(Budapest, Hungria)
2016/07/21 T. Silva, P. Rao, P. Soares da Silva, A. Martínez, F. Remião, J. Garrido, P. Oliveira, F. Borges “Hydroxycinnamic acid as a valid scaffold for the development of multitarget ligands for CNS disorders” 1st annual meeting – MuTaLig COST Action – Università della Svizzera Italiana
(Lugano, Suiça)
2016/03/18 M.D. Magalhães-e-Silva*, R. Hosseini, F. Moosavi, T. Silva, H. Rajaeian, P. Soares, L. Saso, O. Firuzi, F. Borges, “Síntese e caracterização de fatores neurotróficos baseado em compostos fenólicos” 4º Encontro Nacional de Estudantes de Química (ENEQUI)
2015/12/01 D. Magalhães-e-Silva*, R. Hosseini, F. Moosavi, T. Silva, H. Rajaeian, P. Soares, L. Saso, O. Firuzi, F.Borges “Development of neurotrophic agents based on hydroxycinnamic acid scaffold” 11º Encontro Nacional de Química Orgânica / 4º Encontro de Química Terapêutica
(Porto, Portugal)
2015/09/28 T. Silva, F. Borges “Hydroxycinnamic acids: a valid scaffold in Medicinal Chemistry” COST-EPIGEN MEETING
(Budapest, Hungria)
2015/07/03 D. Chavarria, T. Silva, T. Summavielle, F. Borges “Development of novel neuroprotective antioxidants inspired on hydroxycinnamic acid scaffold” V Meeting of the Paul Ehrlich Euro-PhD Network
(Cracow, Polónia)
2015/07/03 T. Silva*, M. Mohamed, P.P.N. Rao, A. Martínez, P. Soares-da-Silva, F. Remião, F. Borges, “5-Nitrocaffeic acid derivatives as multifunctional agents for neurodegenerative diseases” V Meeting of the Paul Ehrlich Euro-PhD Network
(Cracow, Polónia)
2015/07/03 J. Teixeira, C. Oliveira, R. Amorim, T. Silva, F. Cagide, J. Garrido, P. B. Andrade, P. J. Oliveira, F. Borges “Targeting dietary hydroxybenzoic acids to mitochondria: A refined strategy to improve Nature” V Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cracow, Polónia)
2015/07/02 F. Borges, T. Silva, J. Teixeira, F. Cagide, D. Chavarria, D. Magalhães-e-Silva, S. Benfeito*, C. Fernandes, C. Oliveira “Antioxidants: from Nature to drug prototypes” International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress"
(Rome, Itália)
2015/05/27 J. Teixeira*, C. Oliveira, R. Amorim, T. Silva, F. Cagide, J. Garrido, P. J. Oliveira, P.B. Andrade, F. Borges “Targeting dietary phenolic acids to mitochondria: Improving hydroxybenzoic acids antioxidant properties” 49th Annual Scientific Meeting of the European Society for Clinical Investigation
(Cluj-Napoca, Roménia)
2015/05/13 D. Chavarria, T. Silva, J. Bravo, T. Summavielle, F. Borges. “Exploring Cinnamic Acid Scaffold: Development of Promising Neuroprotective Lipophilic Antioxidants.” VIII Encontro de Jovens Investigadores da UP (IJUP)
(Porto, Portugal)
2015/03/27 D. Magalhães-e-Silva, D. Chavarria, T. Silva, F. Borges. “Finding a therapeutic solution for neurodegenerative diseases: design and synthesis of novel neuroprotective agents.” III ENEQUI – “Ilumina o teu conhecimento!"
(Aveiro, Portugal)
2014/06/05 T. Silva, D. Chavarria, L. Sequeira, J. Garrido, T. Summavielle, F. Borges “Biology-oriented Development of Novel Lipophilic Antioxidants With Neuroprotective Activity” World Congress on Polyphenols Applications: ISANH Polyphenols 2014
(Lisbon, Portugal)
2013/09/27 T. Silva*, L. Sequeira, A. Martínez, F. Borges “Towards the development of multi-target directed drugs for neurodegenerative diseases based on the natural cinnamic acid scaffold” 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cagliari, Itália)
2013/09/27 T. Silva, L. Sequeira, A. Martínez, F. Borges "Towards the development of multi-target directed drugs for neurodegenerative diseases based on the natural cinnamic acid scaffold" 3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network
(Cagliari)
2013/02/13 R. P. Matos, T. Silva, P. Valentão, A. P. Oliveira, F. Borges, E. Benfeito, A. Oliveira, S. Meireles, T. M. Brandão, P. B. Andrade «Spergularia rubra: A functional beverage to reduce overweight, obesity and diabetes» IJUP13–6º Encontro de Jovens Investigadores da U. Porto
(Porto, Portugal)
2013/01/09 T. Silva, I. Encarnação, J. Amorim, L. Sequeira, A. Gaspar, J. Garrido, F. Borges «Bridging the gap between nature and phenolic antioxidants» 2nd Workshop on Medicinal Chemistry
(Porto, Portugal)
2011/11/10 T. Silva, A. Gaspar, J. Teixeira, N. Leal, F. Borges, J. Garrido «New solutions for an old problem: surpassing the pharmacokinetic drawbacks of natural phenolic antioxidants» 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Rome, Itália)
2011/11/10 F. Borges*, A. Gaspar, T. Silva, J. Teixeira, F. Cagide, S. Benfeito, C. Oliveira, J. Reis, M. Garrido, J. Garrido, O. Firuzi, L. Saso «Striving for success in antioxidant therapy» 10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants
(Rome, Itália)
2011/10/20 F. Borges, A. Gaspar, J. Garrido, E. M. Garrido, T. Silva, J. Reis, F. Cagide, N. Milhazes, O. Firuzi, L. Saso «Antioxidant therapy: in search of the magic bullet» 2nd World Congress on Targeting Mitochondria–Berlin, Germany, October 20th-21st, 2011
World Mitochondria Society (Berlin, Alemanha)
2009/12/11 T. Silva, T. Silveira «Como Ocorre a Imortalização Celular no Cancro?» I Conferência Microbiologia e Biologia do Cancro
Faculty of Pharmacy, University of Porto (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual Desenvolvimento de novos antioxidantes e quelantes de ferro para o tratamento da doença de Alzheimer
Coorientador
 Chemistry (Outra)
Universidade do Porto Faculdade de Ciências, Portugal
2017 - Atual Synthesis of piperazine derivatives as acetylholinesterase inhibitors as a potential treatment of Alzheimer's disease
Coorientador
 Biochemistry (Outra)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - Atual Desenvolvimento de novos sistemas híbridos cinâmico-colina como estratégia terapêutica para a doença de Alzheimer
Orientador
 Biochemistry (Outra)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - Atual Extracurricular internship (PEEC program), training in organic synthesis
Coorientador
 Biochemistry (Iniciação científica)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - Atual Extracurricular internship program, training in organic synthesis
Coorientador
 Biochemistry (Iniciação científica)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - Atual Extracurricular internship program, training in organic synthesis
Coorientador
 Biochemistry (Iniciação científica)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/07/12 - Atual VIII Meeting of the Paul Ehrlich Euro-PhD Network (2018/07/12)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2014/05/30 - Atual Third workshop in Medicinal Chemistry. Drug Discovery and Development: Understanding the R&D Process (2014/06/30)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2013/01/13 - Atual Second workshop in Medicinal Chemistry. Drug Discovery and Development: Understanding the R&D Process Role: Member of the Organizing Committee (2013/01/13)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - Atual Second Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Ciências, Portugal
2010/05/23 - Atual Doença cardiovascular: uma velha temática, uma nova abordagem (2010/05/23)
Congresso (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019 Design de nanopartículas PEGuiladas de PLGA para diminuição do perfil hepatotóxico da tolcapona
Arguente principal
 Carlos Soares (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Development of Novel Lipophilic Antioxidants as a Therapeutic Solution for Neurodegenerative
Arguente principal
 João Lourenço (Outro)
Universidade do Porto Faculdade de Ciências, Portugal
2018 Design and development of multi-target agents for neurodegenerative diseases Ester Sofia Benfeito (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 Development of new monoamine oxidase (MAO-B) inhibitors based on chromone as potential drugs for the treatment of Parkinson disease
Arguente principal
 Cláudia Tomé (Outro)
Universidade do Porto Faculdade de Ciências, Portugal
2016 Desenvolvimento de novos antioxidantes tendo como base modelos naturais
Arguente principal
 Brandon Aguiar (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Molecules (1420-3049) MDPI AG

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - Atual Bioorganic Chemistry (Mestrado)
2017 - Atual Biological Chemistry (Licenciatura)
2016 - Atual Medicinal Chemistry (Mestrado)

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2013 Article on the importance of cholesterol in Alzheimer's disease.

Membro de associação

Nome da associação Tipo de participação
2020/01 - Atual PT-OPENSCREEN: National Infrastructure for Chemical Biology Compound provider and hit-to-lead optimization

Tutoria

Tópico Nome do aluno
2019 - Atual Synthesis of new antioxidants Taha Koulani
2018 - Atual Synthesis of bifunctional derivatives of kojic acid and deferiprone Francesca Cantisani
2018 - Atual Screening of new hMAO-B inhibitors Paolo Guglielmi
2014 - Atual Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para as Doenças Neurodegenerativas Daniel Chavarria
2014 - Atual Synthesis of 4-aryl derivatives of ferulic acid Francisco Mura
2013 - Atual Desenvolvimento de Novos Antioxidantes Lipofílicos Baseados em Modelos de Origem Natural Lisa Sequeira
Distinções

Prémio

2016 Award of the Paul Ehrlich MedChem Euro-PhD Certificate
2013 EFMC Full grant to attend the XXXIII European School of Medicinal Chemistry (EU)
2012 ADDF Young Investigator Scholarship
Alzheimer's Drug Discovery Foundation, Estados Unidos

Outra distinção

2019 Full grant, CA15135 Multi-Targeting Biophysical Training School, 2nd edition (EU)
2018 Invited Researcher Grant, DTU Chemistry (DK)
2016 CCRN Post-Doctoral Fellowship CIQ-SAM/BIOANTIOX-BPD2 (PT)
2016 FCT Post-Doctoral Fellowship SFRH/BPD/114945/2016 (PT)
2011 Project Research Grant PTDC/QUI-QUI/113687/2009 (PT)
2011 FCT PhD Grant SFRH/BD/79671/2011 (PT)
2010 Erasmus Research Undergraduate Fellowship (EU)