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Mark Stephen Gibson studied for his BSc degree in Biochemistry at the University of Surrey from 1999-2003. He developed his long standing interest in Immunogenetics at the Anthony Nolan Trust from 2003-2006 before undertaking his Master of Science degree in Clinical Biochemistry and Molecular Biology at the University of Surrey. He then completed his PhD in Infection and Immunity at The Pirbright Institute and University College London from 2007-2011. During this time, he cloned & characterised novel members of the chicken Interleukin-1 family. Next, Mark took on a Postdoc position within the Immunogenetics Group at the Pirbright Institute where he characterised Natural Killer cell receptor diversity and function in cattle. After moving to Portugal, he undertook a Postdoc position at the Chronic Diseases Research Centre (CEDOC) in Lisbon, focussed on understanding the molecular mechanisms that regulate sterile inflammation in atherosclerosis. Mark is now a Senior Postdoc in the RNA Systems Biology group within the Biosystems and Integrative Sciences Institute (BioISI), Universidade de Lisboa. His project aims to characterise the role of microRNAs in T-cell function and anti-HIV defence. Mark is also a junior lecturer at Faculdade de Ciencias, Universidade de Lisboa. To date, he has published ten peer-reviewed articles in journals.
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Identification

Personal identification

Full name
Mark Stephen Gibson

Citation names

  • Gibson, Mark S

Author identifiers

Ciência ID
5B19-F05C-F2AD
ORCID iD
0000-0001-9732-8915
Researcher Id
E-5574-2015

Email addresses

  • mark.gibson@euvg.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Elementary (A2) Beginner (A1) Beginner (A1) Elementary (A2)
Education
Degree Classification
2012/01/28
Concluded
 PhD in Infection and Immunity (Doutoramento)
University College London, United Kingdom
"A genetic and functional analysis of the chicken interleukin-1 gene family" (THESIS/DISSERTATION)
 Approved
2007/09/28
Concluded
 MSc in Clinical Biochemistry and Molecular Biology (Mestrado)
University of Surrey, United Kingdom
"Characterisation of the human PERIOD3 gene promoter following construction of a deletion library " (THESIS/DISSERTATION)
 Merit
2003/05/23
Concluded
 Bachelor of Science (BSc) Biochemistry (with honours) (Licenciatura)
University of Surrey, United Kingdom
"PPAR gene expression in cholesterol fed rabbits" (THESIS/DISSERTATION)
 Second Class Honours (2ii) - 14 valores
Affiliation

Science

Category
Host institution 		Employer
2003/09/01 - 2006/10/02 Research Assistant (Research) Anthony Nolan, United Kingdom
2001/09/03 - 2002/08/01 Research Assistant (Research) University College London Division of Biosciences, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2019/10/02 - 2022/01/24 Lecturer (University Teacher) Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2022/11/16 - 2024/04/30 Journal Specialist Frontiers Media SA, Switzerland
2018/11/12 - 2022/10/09 Senior Post-doctoral research scientist (full time). Project: Exploring the role of microRNAs in T cell function and anti-HIV defence. Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2016/01/01 - 2018/01/30 Post-doctoral research scientist (full time) Project: Understanding the molecular mechanisms that regulate sterile inflammation in atherosclerosis Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/08/31 - 2015/10/14 Post-doctoral research scientist (full time) Project: Characterisation of Natural Killer cell receptor diversity & function in cattle Pirbright Institute, United Kingdom
2012/02/13 - 2012/08/30 Post-doctoral research scientist (full time) Project: Characterisation of IL-18 binding protein in the chicken Pirbright Institute - Compton, United Kingdom
2007/10/01 - 2011/09/30 PhD Student (full time) Pirbright Institute - Compton, United Kingdom
Projects

Grant

Designation Funders
2022/01/09 - 2022/10/09 Utilização de microRNAS para direcionamento celular específico de complexos Cas9 com potencial terapêutico
Provided by PTCRIS: EXPL/BTM-ORG/0982/2021
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
2014/09 - 2017/08 Restriction of avian viruses by host interferon-inducible transmembrane proteins (IFITMs)
BB/L003996/1
 Biotechnology and Biological Sciences Research Council

Contract

Designation Funders
2018/11/12 - 2022/10/09 miRiAD - Exploring the role of microRNAs in T cell function and anti-HIV defense
PTDC/BIA-CEL/29257/2017
Post-doc
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/08/31 - 2015/10/14 Dissecting the functional impact of natural killer cell receptor variation in cattle
BB/J006211/1
Post-doc Fellow
Pirbright Institute, United Kingdom
 Biotechnology and Biological Sciences Research Council

Other

Designation Funders
2007/10/01 - 2011/09/30 BBSRC-funded studentship: Genetic and functional analysis of the chicken interleukin-1 gene family
info:eu-repo/grantAgreement/RCUK/BBSRC/BBS2%FE2%FI2%F00001345/GB
PhD Student Fellow
Pirbright Institute - Compton, United Kingdom
 UK Research and Innovation
Concluded
Outputs

Publications

Journal article
  1. "Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection". Genes 13 2 (2022): 273-273. http://dx.doi.org/10.3390/genes13020273.
    10.3390/genes13020273
  2. Gibson, Mark S.; Steyn, Angela; Kealy, David; Kaspers, Bernd; Fife, Mark S.. "Molecular cloning and characterisation of chicken IL-18 binding protein". Developmental & Comparative Immunology 114 (2020): 103850. http://dx.doi.org/10.1016/j.dci.2020.103850.
    Open access • Published • 10.1016/j.dci.2020.103850
  3. Mark S. Gibson; Alasdair J. Allan; Nicholas D. Sanderson; James Birch; Simon Gubbins; Shirley A. Ellis; John A. Hammond. "Two Lineages of KLRA with Contrasting Transcription Patterns Have Been Conserved at a Single Locus during Ruminant Speciation". The Journal of Immunology (2020): ji1801363-ji1801363. https://doi.org/10.4049/jimmunol.1801363.
    10.4049/jimmunol.1801363
  4. Gibson, Mark. "Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis". Frontiers in Physiology (2018): http://europepmc.org/articles/PMC6029489.
    10.3389/fphys.2018.00654
  5. Gibson, Mark. "The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation". Immunogenetics (2017):
    10.1007/s00251-017-0973-y
  6. Gibson, M. S.; Kaiser, P.; Fife, M.. "The chicken IL-1 family: evolution in the context of the studied vertebrate lineage". Immunogenetics 66 7-8 (2014): 427-38.
    10.1007/s00251-014-0780-7
  7. Smith, S. E.; Gibson, M. S.; Wash, R. S.; Ferrara, F.; Wright, E.; Temperton, N.; Kellam, P.; Fife, M.. "Chicken interferon-inducible transmembrane protein 3 restricts influenza viruses and lyssaviruses in vitro". J Virol 87 23 (2013): 12957-66.
    10.1128/JVI.01443-13
  8. Gibson, M. S.; Fife, M.; Bird, S.; Salmon, N.; Kaiser, P.. "Identification, cloning, and functional characterization of the IL-1 receptor antagonist in the chicken reveal important differences between the chicken and mammals". J Immunol 189 2 (2012): 539-50.
    10.4049/jimmunol.1103204
  9. Gibson, M. S.; Salmon, N.; Bird, S.; Kaiser, P.; Fife, M.. "Identification, cloning and characterisation of interleukin-1F5 (IL-36RN) in the chicken". Dev Comp Immunol 38 1 (2012): 136-47.
    10.1016/j.dci.2012.04.014
  10. Archer, S. N.; Carpen, J. D.; Gibson, M.; Lim, G. H.; Johnston, J. D.; Skene, D. J.; von Schantz, M.. "Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder". Sleep 33 5 (2010): 695-701.
  11. Kaiser, P.; Wu, Z.; Rothwell, L.; Fife, M.; Gibson, M.; Poh, T. Y.; Shini, A.; Bryden, W.; Shini, S.. "Prospects for understanding immune-endocrine interactions in the chicken". Gen Comp Endocrinol 163 1-2 (2009): 83-91.
    10.1016/j.ygcen.2008.09.013
  12. Gibson, M. S.; Kaiser, P.; Fife, M.. "Identification of chicken granulocyte colony-stimulating factor (G-CSF/CSF3): the previously described myelomonocytic growth factor is actually CSF3". J Interferon Cytokine Res 29 6 (2009): 339-43.
    10.1089/jir.2008.0103

Intellectual property

Patent
  1. Gibson, Mark S. 2019. "Avian cells for improved virus production".
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/02/01 - 2022/10/09 Dissecting new regulatory mechanisms in retroviral integration and replication: the role of miR-34c-5p in HIV-1 infection
Co-supervisor
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/03/01 - 2017/11/24 Career Opportunities for PostDoctoral Researchers in Life Sciences brought together postdoctoral researchers from across Portugal. The inaugural event hosted a Job Fair, that aimed to promote new career prospects and opportunities for PhD holders. Individuals from key industries and companies showcased their mission and values, and provided PhD holders the opportunity to apply for jobs. Additionally, several workshops presented alternative career options that exist away from the lab. A Scientific Symposium for post-docs preceded the Job Fair. (2017/11/22 - 2017/11/24)
Other (Member of the Organising Committee)

Committee member

Activity description
Role 		Institution / Organization
2016/10 - 2017/12 CEDOC Post-doc committee
Member
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/06 - 2012/10 Research department representative on the rebranding committee
Member
 Pirbright Institute - Compton, United Kingdom
2009/10 - 2010/10 Student representative on the academic committee
Member
 Pirbright Institute - Compton, United Kingdom
2005 - 2006 Research department representative on the staff forum
Member
 Anthony Nolan, United Kingdom

Journal scientific committee

Journal title (ISSN) Publisher
2020/02/12 - Current HLA (2059-2310) Wiley (Blackwell Publishing)
2018/10 - Current The Journal of Leukocyte Biology (1938-3673) Society for Leukocyte Biology
2016/02/01 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2014/07 - Current PLoS ONE (1932-6203) Public Library of Science
2013/08 - Current Cytokine (1096-0023) Elsevier