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Liliana Santos is a PhD Student in Drugs R&D doctoral programme at the University of Coimbra. Her research focuses on elucidating the mechanisms behind the formation of brain metastases in breast cancer in order to identify molecular targets for diagnosis and treatment.
Identification

Personal identification

Full name
Liliana Santos

Citation names

  • Santos, Liliana
  • Santos, L

Author identifiers

Ciência ID
5E1A-2C3C-DBB8
ORCID iD
0000-0003-2525-9572

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2020/04 - 2024
Ongoing
 Drugs R&D doctoral PhD program (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Unravel the role of HER-2 in breast cancer brain metastasis: a pre-clinical approach using anti-HER2 radiolabeled nanobodies" (THESIS/DISSERTATION)
2019/11/04 - 2019/11/15
Concluded
 III Modular Training in Laboratory Animal Science (Outros)
Major in Especialização em Function A
Universidade de Coimbra, Portugal
 17.3
2015/09 - 2017/12
Concluded
 Oncologia (Mestrado)
Major in Oncologia molecular
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission" (THESIS/DISSERTATION)
 18
2012/09 - 2015/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
 15
Affiliation

Others

Category
Host institution 		Employer
2020/04 - Current PhD Student in Drugs R&D doctoral programme Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/10/01 - 2020/03/31 Research fellow (Project: BrainHealth 2020 – Early detection, neuromodulation and advance therapies for neuropathologies) CNC.IBILI, Portugal
2018/05/01 - 2019/09/30 Research Fellow (Project: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy) CNC.IBILI, Portugal
2016/04 - 2018/03 MSc student Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projects

Contract

Designation Funders
2019/10/01 - 2020/03/31 BrainHealth 2020 – Early detection, neuromodulation and advance therapies for neuropathologies
CENTRO-01-0145-FEDER-000008
Research Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/05/01 - 2019/09/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Research Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula F. da Silva; et al. "Unraveling the role of HER2+ breast cancer cells-derived secretome on blood-brain barrier dysfunction in premetastatic niche formation". Paper presented in EACR Conference ’The Tumour Ecosystem: Cellular Interactions and Therapeutic Opportunities’ , Bergamo, Italy, 2024.
  2. Santos, Liliana; Hrynchak, Ivanna; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Célia M. Gomes; Abrunhosa, Antero J. "Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2+ lesions". Paper presented in CIBIT, 2023.
  3. Ferreira, Hugo R. S.; Tomatis, Francesca; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula Silva; Moreira, João Nuno; et al. "Evaluating Blood-Brain Barrier Permeability Changes during Premetastatic Niche Formation for HER2+ Breast Cancer Brain Metastasis". Paper presented in EACR 2023 Congress, Turin, Italy, 2023.
  4. Santos, Liliana; FERREIRA, HUGO; Tomatis, Francesca; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability during the pre-metastatic niche formation". Paper presented in Champalimaud Research Symposium 2022, 2022.
  5. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Amílcar Falcão; Célia Gomes; Abrunhosa, Antero. "GMP Production of 89Zr-DFO-Trastuzumab: from chemistry to the clinic". Paper presented in New Modalities in Cancer Imaging and Therapy, 2022.
  6. Almeida, Sara F.F.; Ribeiro, Gabriela; Abreu, Mónica; Lima, Nuno; Santos, Liliana; Oliveira, Rui C.; Miranda, Catarina O.; et al. "Osteosarcoma-derived secretome modulate the lung microenvironment and accelerate lung metastasis formation". Paper presented in Tumour Microenvironment: from cancer initiation to metastasis, Champalimaud Research Symposium 2022 (CRSy22), 2022.
  7. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery". Paper presented in 5th ASPIC International Congress, 2022.
  8. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Falcao, Amilcar; Gomes, Celia; Abrunhosa, Antero. "Zr-89-immuno-PET imaging: from liquid target production to imaging". 2022.
  9. "The VGF-derived peptide TLQP-21 secreted by brain metastatic breast cancer cells promotes blood-brain barrier dysfunction". Paper presented in EACR 2021 Congress, Innovative Cancer Science: Better Outcomes through Research, 2021.
  10. Almeida, Sara S.F.F. ; Sampaio-Ribeiro, Gabriela; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Miranda, Catarina O.; Almeida, Luís Pereira de; et al. "Pre-metastatic niche formation and lung metastasis in osteosarcoma: an in vivo experimental approach". Paper presented in EACR Seed and soil: in vivo models of metastasis, 2021.
  11. Almeida, Sara F.F.; Ribeiro, Gabriela; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Miranda, Catarina O.; Almeida, Luís Pereira de; et al. "Osteosarcoma cells secretome mimics the effect of a primary tumor in lung premetastatic niche formation". Paper presented in EACR Innovative Cancer Science 2021, 2021.
  12. Almeida, Sara F.F.; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Martins-Marques, Tânia; Ribeiro-Rodrigues, Teresa; Girão, Henrique; et al. "Osteosarcoma cells-derived secretome induce endothelial cell dysfunction and stroma lung damage favourable for metastasis formation". Paper presented in Cancer Biology: From Basic to Translational Research, 2020.
  13. Santos, Liliana; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "The VGF-derived peptide TLQP-21 released by breast cancer cells promotes the loss of brain endothelial cell monolayer integrity". Paper presented in CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH webinar organized by Liga Portuguesa Contra o Cancro, 2020.
  14. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "VGF-secreted peptide derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in Tumor Microenvironment (EACR-AACR Basic and Translational Research Conference in partnership with ASPIC), 2020.
  15. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Silva, Ana Paula; Gomes, Célia; Paredes, Joana; Ribeiro, Ana Sofia. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis". Paper presented in 2nd Joint EACR-MRS Conference. Seed and Soil-In vivo Models of metastasis, 2019.
  16. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "Secretome derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in CIBB Meeting, 2019.
  17. Carvalho, Rita; Cônde, Inês; Santos, Liliana; Leitão, Ricardo Alexandre; Gomes, Célia; Silva, Ana Paula; Paredes, Joana; Ribeiro, Ana. "Characterization of the secretome profile in brain metastic breast cancer cells". Paper presented in 2nd joint EACR-MRS conference - Seed and Soil: mechanisms of metastasis, 2019.
Journal article
  1. Rita Carvalho; Liliana Santos; Inês Conde; Ricardo Leitão; Hugo RS Ferreira; Célia Gomes; Ana Paula Silva; et al. "Nerve growth factor inducible (VGF) is a secreted mediator for metastatic breast cancer tropism to the brain". The Journal of Pathology (2024): https://doi.org/10.1002/path.6319.
    10.1002/path.6319
  2. Santos, Liliana; Moreira, João Nuno; Abrunhosa, Antero; Gomes, Célia. "Brain metastasis: An insight into novel molecular targets for theranostic approaches". Critical Reviews in Oncology/Hematology 198 (2024): 104377. http://dx.doi.org/10.1016/j.critrevonc.2024.104377.
    10.1016/j.critrevonc.2024.104377
  3. Almeida, Sara F.F.; Santos, Liliana; Sampaio-Ribeiro, Gabriela; Ferreira, Hugo R.S.; Lima, Nuno; Caetano, Rui; Abreu, Mónica; et al. "Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling". Journal of Experimental & Clinical Cancer Research 42 1 (2023): http://dx.doi.org/10.1186/s13046-023-02886-9.
    10.1186/s13046-023-02886-9
  4. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R.S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula F. da Silva; et al. "Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability". Fluids and Barriers of the CNS 20 S1 (2023): http://dx.doi.org/10.1186/s12987-023-00417-4.
    10.1186/s12987-023-00417-4
  5. Hrynchak, Ivanna; Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Falcão, Amílcar; Gomes, Célia; Abrunhosa, Antero. "89Zr-immuno-PET imaging: from liquid target production to imaging". Nuclear Medicine and Biology 114-115 (2022): S23-S24. http://dx.doi.org/10.1016/s0969-8051(22)02141-2.
    10.1016/s0969-8051(22)02141-2
  6. Ivanna Hrynchak; Liliana Santos; Amílcar Falcão; Célia M. Gomes; Antero J. Abrunhosa. "Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies". International Journal of Molecular Sciences 22 19 (2021): 10745-10745. https://doi.org/10.3390/ijms221910745.
    10.3390/ijms221910745
  7. Almeida, Sara; Santos, Liliana; Falcão, Amílcar; Gomes, Célia; Abrunhosa, Antero. "In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies". International Journal of Molecular Sciences 21 24 (2020): 9443. http://dx.doi.org/10.3390/ijms21249443.
    Published • 10.3390/ijms21249443
  8. Lima, Ana Rita; Correia, Marcelo; Santos, Liliana; Tavares, Catarina; Rios, Elisabete; Canberk, Sule; Soares, Paula; et al. "S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma". Endocrine 73 1 (2020): 85-97. http://dx.doi.org/10.1007/s12020-020-02546-4.
    10.1007/s12020-020-02546-4
  9. Couto, Marina; Coelho-Santos, Vanessa; Santos, Liliana; Fontes-Ribeiro, Carlos; Silva, Ana Paula; Gomes, Célia M. F.. "The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway". Journal of Cellular Physiology 234 11 (2019): 19750-19760. http://dx.doi.org/10.1002/jcp.28575.
    Published • 10.1002/jcp.28575
  10. Lima, Ana Rita; Santos, Liliana; Correia, Marcelo; Soares, Paula; Sobrinho-Simões, Manuel; Melo, Miguel; Máximo, Valdemar. "Dynamin-Related Protein 1 at the Crossroads of Cancer". Genes 9 2 (2018): 115. http://dx.doi.org/10.3390/genes9020115.
    10.3390/genes9020115
Preprint
  1. Carvalho, Rita; Santos, Liliana; Conde, Inês; Leitão, Ricardo; Ferreira, Hugo R. S.; Gomes, Célia; Silva, Ana Paula; et al. "Deciphering the impact of cancer cell’s secretome and its derived-peptide VGF on breast cancer brain metastasis". 2024. http://dx.doi.org/10.1101/2024.02.22.581537.
    10.1101/2024.02.22.581537
Thesis / Dissertation
  1. Liliana Pereira Santos. "Role of mitochondrial dynamics in Hürthle cell tumours: Coupling, uncoupling and fission". Master, 2017. https://repositorio-aberto.up.pt/handle/10216/109419.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01 Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation IV Metabolism, Ageing & Disease (MAD) Meeting Disease & Therapeutics: from the Past to Future
(Coimbra, Portugal)
2023/10 Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation ASPIC-ASEICA 2023
(Porto, Portugal)
2023/10 Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2-Positive metastatic lesions “Optimizing Imaging and Dose-Response in RadiotherapieS“ workshop
(Erquy, France)
2023/02 Trastuzumab-resistant HER2+ brain-tropic breast cancer cells interfere with the blood-brain barrier permeability: a potential route for brain drug delivery SPF 2023
(Coimbra, Portugal)
2022/09/21 Impact of HER2+ Brain-Tropic Breast Cancer Cells in Blood-Brain Barrier Permeability Blood Brain Barriers 2022
(Bari)
2020 VGF-secreted peptide derived from brain metastatic breast cancer cells induces brain endothelial cells dysfunction SPF 2020 - 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia
(Coimbra, Portugal)
2018/02 Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission Encontro de Investigação jovem da Universidade do Porto - IJUP
(Porto, Portugal)
2017/11 Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission; 6th i3S Annual meeting
(Porto)

Association member

Society Organization name Role
2016 - Current ASPIC and EACR member Sócio
Distinctions

Award

2024 Flash talk award: Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation
2023 Best Oral Presentation Award: Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation
Associação Portuguesa de Investigação em Cancro, Portugal

Asociación Española de Investigación sobre el Cáncer, Spain
2022 EACR Poster Prize: Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery
European Association For Cancer Research, United Kingdom