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Identification

Personal identification

Full name
Leon Schurgers

Citation names

  • Schurgers, Leon

Author identifiers

Ciência ID
7217-439E-10AB
ORCID iD
0000-0001-7867-6957
Education
Degree Classification
2011 - 2012
Concluded
 Basic teaching qualification course (Laurea Specialistica)
Maastricht Universitair Medisch Centrum+, Netherlands
1998/08/01 - 2002/06/21
Concluded
 PhD (Doktor (PhD))
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
"STUDIES ON THE ROLE OF VITAMIN K1 AND K2 IN BONE METABOLISM AND CARDIOVASCULAR DISEASE" (THESIS/DISSERTATION)
1990/09/01 - 1995/06/28
Concluded
 Hematology and Clinical Chemistry at University of Applied Science (Bachelor)
Zuyd Hogeschool, Netherlands
"STUDIES ON THE ROLE OF VITAMIN K1 AND K2 IN BONE METABOLISM AND CARDIOVASCULAR DISEASE" (THESIS/DISSERTATION)
 BSc
Affiliation

Science

Category
Host institution 		Employer
2009/01/01 - Current Principal Investigator (Research) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2002/06/21 - 2008/12/31 Science and Technology Management Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
1995 - 1998 Research Assistant (Research) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands

Teaching in Higher Education

Category
Host institution 		Employer
2017 - Current Full Professor (University Teacher) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Maastricht Universitair Medisch Centrum+, Netherlands
2011 - 2014 Assistant (University Teacher) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands

Positions / Appointments

Category
Host institution 		Employer
2017 - Current Vice chair department of Biochemistry Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Maastricht Universitair Medisch Centrum+, Netherlands
(...)
2017 - Current Board member of MosaCell, a platform for patient derived cells for disease modeling Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2015 - Current Scientific advisor of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2013 - Current Head of the central centrifuge facility MUMC+ Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2014 - 2017 Tenured associate Professor of Biochemistry Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2009 - 2015 Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2009 - 2011 Half-time Assistant Professor of Biochemistry, CARIM, Maastricht University and half-time vice president R&D VitaK, Maastricht University Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2003 - 2009 Scientific Director for the world-wide quality assurance scheme for vitamin K-detection (KEQAS) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
2002 - 2009 Senior researcher at VitaK, Maastricht University Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands

Others

Category
Host institution 		Employer
2017 - 2027 Member of the scientific advisory board of the Dutch Thrombosis society Dutch Thrombosis society, Germany
2013 - 2019 Vice-president experimental animal committee Maastricht University Universiteit Maastricht, Netherlands
2013 - 2019 Member of the scientific advisory board of the Dutch Kidney foundation Dutch Kidney foundation, Germany
2013 - 2019 Treasurer of the Dutch Thrombosis society Dutch Thrombosis society, Germany
2015 - 2018 Member of the annual monitoring committee of the Life Sciences and Health (LSH) impulse programme of ZonMW ZonMw, Netherlands
2012 - 2016 Scientific advisor of the Dutch NIGRAM consortium grant Dutch NIGRAM, Germany
Projects

Grant

Designation Funders
2020 - 2022 RegMedXB – Moonshot Cardiovascular
RegMedXB
Principal investigator
Ongoing
2020 - 2022 Pro-calcifying properties of vitamin K antagonists and potential protective role of Rivaroxaban in the cardiovascular system
Bayer
Researcher
Bayer AG
Ongoing
2019 - 2022 Thrombo-Inflammation in CARDIOvascular disease (TICARDIO)
TICARDIO
Principal investigator
Ongoing
2018 - 2021 Combatting the CardioRenal Syndrome: towards an integrative Analysis to reduce cardiovascular burden in chronic kidney disease (CaReSyAn)
CaReSyAn
Principal investigator
Ongoing
2019 - 2020 Small vessels, big problems: the role of MGP and Alk1 in vascular malformations
Small vessels, big problems
Researcher
Universiteit Maastricht Cardiovascular Research Institute Maastricht
Ongoing
2017 - 2020 International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE (INTRICARE)
INTRICARE
Principal investigator
Concluded
2016 - 2019 European Vascular Interventions and Therapeutic Innovation Network (EVOLuTION; 675111)
EVOLuTION; 675111
Researcher
Concluded
2014 - 2018 Effects of vitamin K-antagonists, vitamin K and new oral anticoagulants on atherogenesis. Trombose Stichting Nederland; 2014-02)
Trombose Stichting Nederland; 2014-02
Principal investigator
Universiteit Maastricht, Netherlands
Concluded
2014 - 2018 The role of vitamin K2 (MK7) on vitamin K-dependent proteins and their effect on bone and vascular calcification. Project 241584
Project 241584
Principal investigator
Concluded
2017 - 2017 Imaging atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2017
Principal investigator
Boehringer Ingelheim Animal Health
Concluded
2014 - 2017 The VitaVasK study: Vitamin K1 to Slow Vascular Calcification in Hemodialysis Patients. European Renal Association
VitaVasK study
Researcher
Clinical Trial Center Maastricht, Netherlands
 European Dialysis and Transplant Nurses Association/European Renal Care Association
Concluded
2014 - 2017 BRAEDEN: a BioHybrid platform Replacing Animal Experiments for Drug Efficacy iNvestigations
BRAEDEN
Researcher
Concluded
2012 - 2012 UMouse: reporter mouse for vascular smooth muscle cell health in vivo (2012)
UMouse
Principal investigator
Maastricht Universitair Medisch Centrum+, Netherlands
Concluded
2006 - 2011 Menaquinone-7 as dietary supplement to prevent bone loss and vascular calcification
VitaK BV
Researcher
Clinical Trial Center Maastricht, Netherlands
Concluded

Contract

Designation Funders
2002 - Current Vascular smooth muscle cells and vascular calcification
#16, 28, 36, 64, 84, 95, 121, 140
Invited Scientist Fellow
British Heart Foundation, United Kingdom
Ongoing

Other

Designation Funders
2013 - Current Vitamin K2 and cardiovascular healthy
NattoPharma2013
Principal investigator
Maastricht Universitair Medisch Centrum+, Netherlands
Ongoing
2006 - Current Chronic kidney disease and vascular calcification
#13, 47, 51, 55, 58, 66, 79, 90, 105, 114, 130, 137
Integration into Research Grant Fellow
Deutsche Forschungsgemeinschaft, Germany
Ongoing
2006 - Current Mutations in ABCC6 resulting in PXE and elastin calcification
#25, 48, 49, 81, 106, 107, 113
Ongoing
2001 - Current Vitamin K detection
#11, 18, 59, 89, 108, 128
Integration into Research Grant Fellow
Ongoing
2001 - Current Endogenous inhibitors of arterial calcification
#16, 51, 90, 95, 105, 111
Integration into Research Grant Fellow
Ongoing
2017 - 2021 The role of vitamin K2 (MK7) on the calcium paradox. Project 241584
Project 241584
Principal investigator
Ongoing
2015 - 2015 Imaging atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2015
Principal investigator
Maastricht Universitair Medisch Centrum+, Netherlands
 Boehringer Ingelheim Animal Health
Concluded
2013 - 2013 Comparative study of effects of Dabigatran and Warfarin on atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2013
Principal investigator
Maastricht Universitair Medisch Centrum+, Netherlands
 Boehringer Ingelheim Animal Health
Concluded
Outputs

Publications

Book
  1. Leon Schurgers. Vasculaire verkalking. Maastricht University. 2018.
    10.26481/spe.20181012ls
  2. Shearer, M.J.; Gorska, R.; Harrington, D.J.; Schurgers, L.J.; Newman, P.. Vitamins and vitamin-like nutrients for prevention of human diseases. 2011.
  3. Schurgers, Leon. Vitamin K. In: Vitamins and vitamin-like nutrients for prevention of human diseases. Netherlands. 2010.
    Published
  4. Schurgers, Leon. Large artery calcification. 2009.
    Published
  5. Schurgers, L.J.; Knapen, M.H.J.; Vermeer, C.. Vitamin K2 improves bone strength in postmenopausal women. 2007.
    10.1016/j.ics.2006.08.006
  6. Leunissen, Mariska. Direct testing for deficiencies. Oxford University Press. 2005.
    Published • 10.1093/acprof:oso/9780190602215.003.0006
  7. Schurgers, Leon. Vitamin K supplementation: a simple way to improve bone and vascular health. 2003.
    Published
  8. Schurgers, Leon. Potential applications of vitamin K-containing products. 2003.
    Published
  9. Schurgers, Leon. Vitamin K enrichment: a new challenge for functional foods that target vascular and bone health. 2002.
    Published
  10. Schurgers, Leon. Increased vitamin K intake by functional foods or food supplements: a new lead to improve cardiovascular and bone health. 2002.
    Published
  11. Schurgers, Leon. Vitamin K-enrichment: a new challenge for functional foods that target cardiovascular and bone health. 2002.
    Published
  12. Schurgers, Leon. Role of vitamin K in vascular mineralization and in reduction of arterial thrombosis. In: Vitamin K and aging. National Academies Press. 1998.
    Published • 10.17226/949
Journal article
  1. Stefanos Roumeliotis; Vassilios Liakopoulos; Leon J. Schurgers. "Vitamin K supplementation in chronic kidney disease patients: where is the evidence?". Current Vascular Pharmacology (2022): https://doi.org/10.2174/1570161120666220209145341.
    10.2174/1570161120666220209145341
  2. Nicoline H J Leenders; Caro Bos; Tiny Hoekstra; Leon J Schurgers; Marc G Vervloet; Joost G J Hoenderop. "Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease". Nephrology Dialysis Transplantation (2022): https://doi.org/10.1093/ndt/gfac026.
    10.1093/ndt/gfac026
  3. Dawid M. Kaczor; Rafael Kramann; Tilman M. Hackeng; Leon J. Schurgers; Rory R. Koenen. "Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23020580.
    10.3390/ijms23020580
  4. Rachid Tobal; Judith Potjewijd; Vanessa P M van Empel; Renee Ysermans; Leon Schurgers; Chris P Reutelingsperger; Jan Damoiseaux; Pieter van Paassen. "Vascular Remodeling in Pulmonary Arterial Hypertension". Frontiers in medicine 8 (2021): 806899-806899. https://cris.maastrichtuniversity.nl/en/publications/7f6bddd8-e430-44b3-957d-bbdd1a3d2bb4.
    10.3389/fmed.2021.806899
  5. Anton S M Dofferhoff; Ianthe Piscaer; Leon Schurgers; Margot P J Visser; Jody M W van den Ouweland; Pim A de Jong; Reinoud Gosens; et al. "Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019". Clinical Infectious Diseases 73 11 (2021): E4039-E4046. https://cris.maastrichtuniversity.nl/en/publications/c97e2958-f726-4191-91d4-2a8dd777ea19.
    10.1093/cid/ciaa1258
  6. Dion Groothof; Adrian Post; Camilo G Sotomayor; Charlotte A Keyzer; Jose L Flores-Guerero; Eelko Hak; Jens H J Bos; et al. "Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria". Nephrology Dialysis Transplantation 36 12 (2021): 2290-2299. https://cris.maastrichtuniversity.nl/en/publications/358bb37d-5d1a-45fa-909c-811aeb00f6b1.
    10.1093/ndt/gfaa304
  7. N. Kaesler; Leon Schurgers; J. Floege. "Vitamin K and cardiovascular complications in chronic kidney disease patients". Kidney International 100 5 (2021): 1023-1036. https://cris.maastrichtuniversity.nl/en/publications/1b71c438-eead-40b3-b8c7-5d3cc785819c.
    10.1016/j.kint.2021.06.037
  8. E. Hariri; N. Kassis; J.P. Iskandar; Leon Schurgers; A. Saad; O. Abdelfattah; A. Bansal; et al. "Vitamin K-2-a neglected player in cardiovascular health: a narrative review". Open Heart 8 2 (2021): https://cris.maastrichtuniversity.nl/en/publications/63a57381-ba58-4a3f-ba61-bb28aee9f2bc.
    10.1136/openhrt-2021-001715
  9. Alexandru Florea; Agnieszka Morgenroth; Jan Bucerius; Leon Schurgers; Felix Mottaghy. "Locking and loading the bullet against micro-calcification". European Journal of Preventive Cardiology 28 12 (2021): 1370-1375. https://cris.maastrichtuniversity.nl/en/publications/6a84eaec-3b26-4965-8b2d-eff35a32e2a2.
    10.1177/2047487320911138
  10. Aegida Neradova; Grzegorz Wasilewski; Selene Prisco; Peter Leenders; Marjolein Caron; Tim Welting; Bert van Rietbergen; et al. "Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure". Nephrology Dialysis Transplantation (2021): https://cris.maastrichtuniversity.nl/en/publications/cdea6ad0-e6e7-4f1a-a5ae-0e3546ecb817.
    10.1093/ndt/gfab314
  11. Nikolas Rapp; Vincent M. Brandenburg; Nadine Kaesler; Stephan Bakker; Robert Stöhr; Alexander Schuh; Pieter Evenepoel; Leon Schurgers. "Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk". Nutrients (2021): https://www.mdpi.com/2072-6643/13/10/3490.
    10.3390/nu13103490
  12. Daan Kremer; Dion Groothof; Charlotte A. Keyzer; Coby Eelderink; Tim J. Knobbe; Adrian Post; Marco van Londen; et al. "Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies". Nutrients 13 9 (2021): 3069-3069. https://doi.org/10.3390/nu13093069.
    10.3390/nu13093069
  13. Armand Jaminon; Asim C. Akbulut; Niko Rapp; Rafael Kramann; Erik A. L. Biessen; Lieve Temmerman; Barend Mees; et al. "Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity". Cells (2021): https://www.mdpi.com/2073-4409/10/8/2097.
    10.3390/cells10082097
  14. Sofia Dahlberg; Ulf Schött; Emilia Ängeby Eriksson; Yllnor Tahirsylaj; Leon Schurgers; Thomas Kander. "Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study". Nutrients 13 8 (2021): 2580-2580. https://doi.org/10.3390/nu13082580.
    10.3390/nu13082580
  15. Ploingarm Petsophonsakul; Mathias Burgmaier; Brecht Willems; Sylvia Heeneman; Nadina Stadler; Felix Gremse; Sebastian Reith; et al. "Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells". Cardiovascular Research (2021): https://cris.maastrichtuniversity.nl/en/publications/ae7dbf3d-9500-4091-9653-14ad7dfaaf73.
    10.1093/cvr/cvab244
  16. Shaiv Parikh; Berta Ganizada; Gijs Debeij; Ehsan Natour; Jos Maessen; Bart Spronck; Leon Schurgers; et al. "Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta". Biomedicines 9 6 (2021): 670-670. https://doi.org/10.3390/biomedicines9060670.
    10.3390/biomedicines9060670
  17. Lu Dai; Leon Schurgers; Paul G Shiels; Peter Stenvinkel. "A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases". Clinical Science 135 10 (2021): 1251-1272. https://cris.maastrichtuniversity.nl/en/publications/71a540cc-3ec5-4f1d-864e-58de69aab14d.
    10.1042/CS20201452
  18. Michael I. McBurney; Jeffrey Blumberg; Rebecca B. Costello; Manfred Eggersdorfer; John W. Erdman; William S. Harris; Elizabeth J. Johnson; et al. "Beyond Nutrient Deficiency—Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations". Nutrients (2021): https://www.mdpi.com/2072-6643/13/6/1844.
    10.3390/nu13061844
  19. Till Seime; Asim Cengiz Akbulut; Moritz Lindquist Liljeqvist; Antti Siika; Hong Jin; Greg Winski; Rick H. van Gorp; et al. "Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification". Cells (2021): https://www.mdpi.com/2073-4409/10/6/1276.
    10.3390/cells10061276
  20. Rick H van Gorp; Ingrid Dijkgraaf; Vanessa Bröker; Matthias Bauwens; Peter Leenders; Danyel Jennen; Marc R Dweck; et al. "Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate". Journal of Thrombosis and Haemostasis 19 5 (2021): 1348-1363. https://cris.maastrichtuniversity.nl/en/publications/1c7c13ca-b79b-4dae-a5a6-0f9e2425d247.
    10.1111/jth.15289
  21. Kim van Kuijk; J A F Demandt; J Perales-Patón; T L Theelen; C Kuppe; E Marsch; Jenny de Bruijn; et al. "Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling". Cardiovascular Research (2021): https://cris.maastrichtuniversity.nl/en/publications/d474462c-af18-4196-9a1d-f8636126c7e4.
    10.1093/cvr/cvab152
  22. M. Fusaro; G. Cianciolo; P. Evenepoel; Leon Schurgers; M. Plebani. "Vitamin K in CKD Bone Disorders". Calcified Tissue International 108 4 (2021): 476-485. https://cris.maastrichtuniversity.nl/en/publications/5c24281c-894a-4674-94a4-7a21609788b6.
    10.1007/s00223-020-00792-2
  23. Adriana J. van Ballegooijen; Joline W. J. Beulens; Lyanne M. Kieneker; Martin H. de Borst; Ron T. Gansevoort; Ido P. Kema; Leon Schurgers; Marc G. Vervloet; Stephan J. L. Bakker. "Combined low vitamin D and K status amplifies mortality risk". European Journal of Nutrition 60 3 (2021): 1645-1654. https://cris.maastrichtuniversity.nl/en/publications/22cf7f08-0ebd-4b31-8c4e-a516fb855bfe.
    10.1007/s00394-020-02352-8
  24. Alexandru Florea; M. Eline Kooi; Werner Mess; Leon J. Schurgers; Jan Bucerius; Felix M. Mottaghy. "Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[18F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design". Nutrients 13 3 (2021): 994-994. https://doi.org/10.3390/nu13030994.
    10.3390/nu13030994
  25. Lu Dai; Longkai Li; Helen Erlandsson; Armand Jaminon; Abdul Rashid Qureshi; Jonaz Ripsweden; Torkel B Brismar; et al. "Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease". PLOS ONE 16 2 (2021): e0247623-e0247623. https://cris.maastrichtuniversity.nl/en/publications/51a7b6b5-e7d0-4f74-b153-0e7f972be6b9.
    10.1371/journal.pone.0247623
  26. Malgorzata Furmanik; Rick van Gorp; Meredith Whitehead; Sadia Ahmad; Jayanta Bordoloi; Alexander Kapustin; Leon J. Schurgers; Catherine M. Shanahan. "Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles". Arteriosclerosis, Thrombosis, and Vascular Biology 41 2 (2021): 898-914. https://doi.org/10.1161/ATVBAHA.120.315506.
    10.1161/ATVBAHA.120.315506
  27. Alexandru Florea; Julius P. Sigl; Agnieszka Morgenroth; Andreas Vogg; Sabri Sahnoun; Oliver H. Winz; Jan Bucerius; Leon J. Schurgers; Felix M. Mottaghy. "Sodium [18F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment". Cells 10 2 (2021): 275-275. https://doi.org/10.3390/cells10020275.
    10.3390/cells10020275
  28. Zhenyu Hao; Da-Yun Jin; Xuejie Chen; Leon J. Schurgers; Darrel W. Stafford; Jian-Ke Tie. "¿-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins". Blood (2021): https://doi.org/10.1182/blood.2020006329.
    10.1182/blood.2020006329
  29. A.C. Akbulut; G.B. Wasilewski; N. Rapp; F. Forin; H. Singer; K.J. Czogalla-Nitsche; Leon Schurgers. "Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells". Frontiers in Cell and Developmental Biology 8 (2021): https://cris.maastrichtuniversity.nl/en/publications/cbecacd7-752d-4a5e-ab17-34a1b4b1ac42.
    10.3389/fcell.2020.618760
  30. Nikolas Rapp; Pieter Evenepoel; Peter Stenvinkel; Leon Schurgers. "Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees". Toxins 12 10 (2020): 624-624. https://doi.org/10.3390/toxins12100624.
    10.3390/toxins12100624
  31. Malgorzata Furmanik; Martijn Chatrou; Rick van Gorp; Asim Akbulut; Brecht Willems; Harald H. H. W. Schmidt; Guillaume van Eys; et al. "Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification". Circulation Research 127 7 (2020): 911-927. https://cris.maastrichtuniversity.nl/en/publications/6d2b25f6-9107-4d02-ad2e-fb68748635f8.
    10.1161/CIRCRESAHA.119.316159
  32. S.W.P. Haroon; C. Tai; L.H. Ling; L. Teo; A. Davenport; Leon Schurgers; B.W. Teo; et al. "Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK) A study protocol for a randomized controlled trial". Medicine 99 36 (2020): https://cris.maastrichtuniversity.nl/en/publications/0e0c4815-44aa-47af-96b1-1c3e458b2377.
    10.1097/MD.0000000000021906
  33. Sabine R. Zwakenberg; Pim A. de Jong; Eva J. Hendriks; Jan Westerink; Wilko Spiering; Gert J. de Borst; Maarten J. Cramer; et al. "Intimal and medial calcification in relation to cardiovascular risk factors". PLOS ONE 15 7 (2020): https://cris.maastrichtuniversity.nl/en/publications/1dad5c1f-c6e9-44b9-a7c0-181efc2d7f58.
    10.1371/journal.pone.0235228
  34. Frederique E. C. M. Peeters; Dudink EAMP; Bob Weijs; Larissa Fabritz; Winnie Chua; Bas Kietselaer; Joachim Wildberger; et al. "Biomarkers Associated With Aortic Valve Calcification". Frontiers in Cell and Developmental Biology 8 (2020): https://cris.maastrichtuniversity.nl/en/publications/81c40662-f66f-4f33-9638-e074a3cb88d3.
    10.3389/fcell.2020.00604
  35. Asim Cengiz Akbulut; Angelina Pavlic; Ploingarm Petsophonsakul; Maurice Halder; Katarzyna Maresz; Rafael Kramann; Leon Schurgers. "Vitamin K2 Needs an RDI Separate from Vitamin K1". Nutrients 12 6 (2020): 1852-1852. https://doi.org/10.3390/nu12061852.
    10.3390/nu12061852
  36. Lu Dai; Björn K. Meijers; Bert Bammens; Henriette de Loor; Leon J. Schurgers; Abdul Rashid Qureshi; Peter Stenvinkel; Pieter Evenepoel. "Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug–Bug Interaction?". Toxins 12 6 (2020): 351-351. https://doi.org/10.3390/toxins12060351.
    10.3390/toxins12060351
  37. Armand Jaminon; Lu Dai; Abdul Rashid Qureshi; Pieter Evenepoel; Jonaz Ripsweden; Magnus Soderberg; Anna Witasp; et al. "Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease". Scientific Reports 10 1 (2020): https://cris.maastrichtuniversity.nl/en/publications/76acec4f-654f-42b3-b632-67e0701dfb88.
    10.1038/s41598-020-63013-8
  38. Elisa d'Alessandro; Christian Becker; Wolfgang Bergmeier; Christoph Bode; Joshua H. Bourne; Helena Brown; Harry R. Buller; et al. "Thrombo-Inflammation in Cardiovascular Disease". Thrombosis and Haemostasis 120 4 (2020): 538-564. https://cris.maastrichtuniversity.nl/en/publications/4443f5b1-76c4-40ea-baf9-0660bd4223d2.
    10.1055/s-0040-1708035
  39. Lu Dai; Leon Schurgers; Paul G. Shiels; Peter Stenvinkel. "Early vascular ageing in chronic kidney disease". Nephrology Dialysis Transplantation 35 (2020): 31-37. https://cris.maastrichtuniversity.nl/en/publications/296e8cf3-8ed5-44a1-a525-006416681add.
    10.1093/ndt/gfaa006
  40. Lu Dai; Oscar Plunde; Abdul Rashid Qureshi; Bengt Lindholm; Torkel B. Brismar; Leon J. Schurgers; Magnus Söderberg; et al. "Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease". Journal of Clinical Medicine 9 2 (2020): 607-607. https://doi.org/10.3390/jcm9020607.
    10.3390/jcm9020607
  41. Nadine Kaesler; Claudia Goettsch; Daniel Weis; Leon Schurgers; Burkhard Hellmann; Juergen Floege; Rafael Kramann. "Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia". Nephrology Dialysis Transplantation 35 1 (2020): 65-73. https://cris.maastrichtuniversity.nl/en/publications/998d447d-da22-4a71-8fa0-978a3da3e430.
    10.1093/ndt/gfy410
  42. Liv M. Vossen; Abraham A. Kroon; Leon J. Schurgers; Peter W. de Leeuw. "Pharmacological and Nutritional Modulation of Vascular Calcification". Nutrients (2019): https://doi.org/10.3390/nu12010100.
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  43. Jelle J. Posthuma; Jens J. N. Posma; Rene van Oerle; Peter Leenders; Rick H. van Gorp; Armand M. G. Jaminon; Nigel Mackman; et al. "Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-019-40602-w.
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  44. Armand Jaminon; Koen Reesink; Abraham Kroon; Leon Schurgers. "The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes". International Journal of Molecular Sciences 20 22 (2019): 5694-5694. https://doi.org/10.3390/ijms20225694.
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  45. Maurice Halder; Ploingarm Petsophonsakul; Asim Akbulut; Angelina Pavlic; Frode Bohan; Eric Anderson; Katarzyna Maresz; Rafael Kramann; Leon Schurgers. "Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease". International Journal of Molecular Sciences 20 4 (2019): 896-896. https://doi.org/10.3390/ijms20040896.
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  46. Grzegorz B. Wasilewski; Marc G. Vervloet; Leon Schurgers. "The Bone-Vasculature Axis". Frontiers in cardiovascular medicine 6 (2019): 1-16. https://cris.maastrichtuniversity.nl/en/publications/b4429776-d956-473f-8a19-82051c88dadd.
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  47. Sofia Dahlberg; Leon Schurgers; Ulf Schött; Thomas Kander. "Vitamin K deficiency in critical ill patients; a prospective observational study". Journal of Critical Care 49 (2019): 105-109. https://doi.org/10.1016/j.jcrc.2018.10.022.
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  48. Adriana J. van Ballegooijen; Joline W. J. Beulens; Leon Schurgers; Elisa J. de Koning; Paul Lips; Natasja M. van Schoor; Marc Vervloet. "Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults". Nutrients (2019): http://www.mdpi.com/2072-6643/11/2/231.
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  49. Ruth Gussenhoven; Luise Klein; Daan Ophelders; Denise H. J. Habets; Bernd Giebel; Boris W. Kramer; Leon Schurgers; Chris P. M. Reutelingsperger; Tim G. A. M. Wolfs. "Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy". Journal of Clinical Medicine (2019): http://www.mdpi.com/2077-0383/8/2/137.
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  51. Dekker, L.H.; Vinke, P.C.; Riphagen, I.J.; Minovic, I.; Eggersdorfer, M.L.; van den Heuvel, E.G.H.M.; Schurgers, L.J.; et al. "Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population". Frontiers in Nutrition 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077368556&partnerID=MN8TOARS.
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  52. Bucerius, J.; Dijkgraaf, I.; Mottaghy, F.M.; Schurgers, L.J.. "Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon". European Journal of Nuclear Medicine and Molecular Imaging 46 1 (2019): 251-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054871866&partnerID=MN8TOARS.
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  53. Schumacher, S.P.; Schurgers, L.J.; Vervloet, M.G.; Neradova, A.. "Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study". Nephrology 24 2 (2019): 221-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044849834&partnerID=MN8TOARS.
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  54. Dudink, E.; Florijn, B.; Weijs, B.; Duijs, J.; Luermans, J.; Peeters, F.; Schurgers, L.; et al. "Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles". MicroRNA (Shariqah, United Arab Emirates) 8 2 (2019): 127-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062602920&partnerID=MN8TOARS.
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  55. Rao, P.S.; Ramanjaneyulu, Y.S.; Prisk, V.R.; Schurgers, L.J.. "A combination of tamarindus indica seeds and curcuma longa rhizome extracts improves knee joint function and alleviates pain in non-arthritic adults following physical activity". International Journal of Medical Sciences 16 6 (2019): 845-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069456433&partnerID=MN8TOARS.
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  57. Peeters, M.T.J.; Houben, R.; Postma, A.A.; van Oostenbrugge, R.J.; Schurgers, L.J.; Staals, J.. "Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage". Frontiers in Neurology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077440861&partnerID=MN8TOARS.
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  58. R. Stöhr; N. Deckers; L. Schurgers; N. Marx; C. P. Reutelingsperger. "AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-35995-z.
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  59. Arnaud Michaux; Benjamin Matagrin; Jean-Valéry Debaux; Leon J. Schurgers; Etienne Benoit; Virginie Lattard. "Missense mutation of VKORC1 leads to medial arterial calcification in rats". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-31788-6.
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  61. Thijs T. Jansz; Xianwu Cheng; Aegida Neradova; Adriana J. van Ballegooijen; Marianne C. Verhaar; Marc G. Vervloet; Leon J. Schurgers; Brigit C. van Jaarsveld. "The role of kidney transplantation and phosphate binder use in vitamin K status". PLOS ONE (2018): https://doi.org/10.1371/journal.pone.0203157.
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  62. Schurgers, Leon. "Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study". Nutrients (2018): http://www.mdpi.com/2072-6643/10/6/734.
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  64. Leon Schurgers; Asim C. Akbulut; Dawid Kaczor; Maurice Halder; Rory Koenen; Rafael Kramann. "Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles". Frontiers in cardiovascular medicine 5 (2018): https://cris.maastrichtuniversity.nl/en/publications/b7d207e1-03a5-44e9-8bb7-d40273f80b16.
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  155. Schlieper, G.; Grotemeyer, D.; Aretz, A.; Schurgers, L.J.; Krüger, T.; Rehbein, H.; Weirich, T.E.; et al. "Analysis of Calcifications in Patients with Coral Reef Aorta". Annals of Vascular Surgery 24 3 (2010): 408-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649183741&partnerID=MN8TOARS.
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  156. Hristova, M.; Van Beek, C.; Schurgers, L.J.; Lanske, B.; Danziger, J.. "Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation". American Journal of Kidney Diseases 56 6 (2010): 1158-1162. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649450075&partnerID=MN8TOARS.
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  157. Rennenberg, R.J.M.W.; Schurgers, L.J.; Kroon, A.A.; Stehouwer, C.D.A.. "Arterial calcifications". Journal of Cellular and Molecular Medicine 14 9 (2010): 2203-2210. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649386955&partnerID=MN8TOARS.
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  158. Cosemans, J.M.E.M.; Van Kruchten, R.; Olieslagers, S.; Schurgers, L.J.; Verheyen, F.K.; Munnix, I.C.A.; Waltenberger, J.; et al. "Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization". Journal of Thrombosis and Haemostasis 8 8 (2010): 1797-1808. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958559483&partnerID=MN8TOARS.
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  159. Westenfeld, R.; Schäfer, C.; Krüger, T.; Haarmann, C.; Schurgers, L.J.; Reutelingsperger, C.; Ivanovski, O.; et al. "Fetuin-A protects against atherosclerotic calcification in CKD". Journal of the American Society of Nephrology 20 6 (2009): 1264-1274. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449102482&partnerID=MN8TOARS.
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  160. Cranenburg, E.C.M.; Brandenburg, V.M.; Vermeer, C.; Stenger, M.; Mühlenbruch, G.; Mahnken, A.H.; Gladziwa, U.; Ketteler, M.; Schurgers, L.J.. "Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients". Thrombosis and Haemostasis 101 2 (2009): 359-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-62449309045&partnerID=MN8TOARS.
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  161. Koos, R.; Krueger, T.; Westenfeld, R.; Kühl, H.P.; Brandenburg, V.; Mahnken, A.H.; Stanzel, S.; et al. "Relation of circulating matrix Gla-protein and anticoagulation status in patients with aortic valve calcification". Thrombosis and Haemostasis 101 4 (2009): 706-713. http://www.scopus.com/inward/record.url?eid=2-s2.0-64849110662&partnerID=MN8TOARS.
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  162. Krüger, T.; Westenfeld, R.; Schurgers, L.J.; Brandenburg, V.M.. "Coagulation meets calcification: The vitamin K system". International Journal of Artificial Organs 32 2 (2009): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649311819&partnerID=MN8TOARS.
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  163. Li, Q.; Grange, D.K.; Armstrong, N.L.; Whelan, A.J.; Hurley, M.Y.; Rishavy, M.A.; Hallgren, K.W.; et al. "Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes". Journal of Investigative Dermatology 129 3 (2009): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-59949086567&partnerID=MN8TOARS.
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  164. Van Summeren, M.J.H.; Braam, L.A.J.L.M.; Lilien, M.R.; Schurgers, L.J.; Kuis, W.; Vermeer, C.. "The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children". British Journal of Nutrition 102 8 (2009): 1171-1178. http://www.scopus.com/inward/record.url?eid=2-s2.0-73749086347&partnerID=MN8TOARS.
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  165. Mertsch, S.; Schurgers, L.J.; Weber, K.; Paulus, W.; Senner, V.. "Matrix gla protein (MGP): An overexpressed and migration-promoting mesenchymal component in glioblastoma". BMC Cancer 9 (2009): 302-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349873207&partnerID=MN8TOARS.
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  166. Card, D.J.; Shearer, M.J.; Schurgers, L.J.; Harrington, D.J.. "The external quality assurance of phylloquinone (vitamin K1) analysis in human serum". Biomedical Chromatography 23 12 (2009): 1276-1282. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649092932&partnerID=MN8TOARS.
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  167. Rennenberg, R.J.M.W.; Schurgers, L.J.; Vermeer, C.. "Vitamin K in postmenopausal osteopenia,Vitamine K bij postmenopauzale osteopenie". Nederlands Tijdschrift voor Geneeskunde 153 25 (2009): 1204-1205. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957656165&partnerID=MN8TOARS.
  168. Brandenburg, V.; Schurgers, L.J.; Krüger, T.; Westenfeld, R.. "Vitamin K: Its role in bone and vascular health,Rolle des vitamin K bei der knochen- und gefäßgesundheit". Nieren- und Hochdruckkrankheiten 38 8 (2009): 372-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949102957&partnerID=MN8TOARS.
  169. Rennenberg, R.J.M.W.; Kessels, A.G.H.; Schurgers, L.J.; Van Engelshoven, J.M.A.; De Leeuw, P.W.; Kroon, A.A.. "Vascular calcifications as a marker of increased cardiovascular risk: A meta-analysis". Vascular Health and Risk Management 5 (2009): 185-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449105670&partnerID=MN8TOARS.
  170. Parker, B.D.; Ix, J.H.; Cranenburg, E.C.M.; Vermeer, C.; Whooley, M.A.; Schurgers, L.J.. "Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study". Nephrology Dialysis Transplantation 24 7 (2009): 2095-2101. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651089927&partnerID=MN8TOARS.
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  171. Schlieper, G.; Brandenburg, V.; Djuric, Z.; Damjanovic, T.; Markovic, N.; Schurgers, L.; Krüger, T.; et al. "Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients". Kidney and Blood Pressure Research 32 3 (2009): 161-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-66049132128&partnerID=MN8TOARS.
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  172. Krueger, T.; Westenfeld, R.; Ketteler, M.; Schurgers, L.J.; Floege, J.. "Vitamin K deficiency in CKD patients: A modifiable risk factor for vascular calcification?". Kidney International 76 1 (2009): 18-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449146899&partnerID=MN8TOARS.
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  173. Li, Q.; Schurgers, L.J.; Smith, A.C.M.; Tsokos, M.; Uitto, J.; Cowen, E.W.. "Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: Compound heterozygosity for mutations in the GGCX gene". American Journal of Pathology 174 2 (2009): 534-540. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649091261&partnerID=MN8TOARS.
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  174. Shroff, R.C.; Shah, V.; Hiorns, M.P.; Schoppet, M.; Hofbauer, L.C.; Hawa, G.; Schurgers, L.J.; et al. "The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis". Nephrology Dialysis Transplantation 23 10 (2008): 3263-3271. http://www.scopus.com/inward/record.url?eid=2-s2.0-52449095331&partnerID=MN8TOARS.
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  175. Schurgers, L.J.; Cranenburg, E.C.M.; Vermeer, C.. "Matrix Gla-protein: The calcification inhibitor in need of vitamin K". Thrombosis and Haemostasis 100 4 (2008): 593-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949147219&partnerID=MN8TOARS.
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  176. van Summeren, M.J.H.; Hameleers, J.M.; Schurgers, L.J.; Hoeks, A.P.G.; Uiterwaal, C.S.P.M.; Krüger, T.; Vermeer, C.; Kuis, W.; Lilien, M.R.. "Circulating calcification inhibitors and vascular properties in children after renal transplantation". Pediatric Nephrology 23 6 (2008): 985-993. http://www.scopus.com/inward/record.url?eid=2-s2.0-42649138549&partnerID=MN8TOARS.
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  177. Golledge, J.; Jayalath, R.; Oliver, L.; Parr, A.; Schurgers, L.; Clancy, P.. "Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification". Atherosclerosis 197 1 (2008): 428-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449130169&partnerID=MN8TOARS.
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  178. Wallin, R.; Schurgers, L.; Wajih, N.. "Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification". Thrombosis Research 122 3 (2008): 411-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849129853&partnerID=MN8TOARS.
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  179. Hermans, M.M.H.; Vermeer, C.; Kooman, J.P.; Brandenburg, V.; Ketteler, M.; Gladziwa, U.; Rensma, P.L.; Leunissen, K.M.L.; Schurgers, L.J.. "Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index". Blood Purification 25 5-6 (2008): 395-401. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849164395&partnerID=MN8TOARS.
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  180. van Summeren, M.J.H.; Spliet, W.G.M.; van Royen-Kerkhof, A.; Vermeer, C.; Lilien, M.; Kuis, W.; Schurgers, L.J.. "Calcinosis in juvenile dermatomyositis: A possible role for the vitamin K-dependent protein matrix Gla protein". Rheumatology 47 3 (2008): 267-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449098773&partnerID=MN8TOARS.
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  181. Shroff, R.C.; McNair, R.; Figg, N.; Skepper, J.N.; Schurgers, L.; Gupta, A.; Hiorns, M.; et al. "Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis". Circulation 118 17 (2008): 1748-1757. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449101447&partnerID=MN8TOARS.
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  182. Schlieper, G.; Krüger, T.; Djuric, Z.; Damjanovic, T.; Markovic, N.; Schurgers, L.J.; Brandenburg, V.M.; et al. "Vascular access calcification predicts mortality in hemodialysis patients". Kidney International 74 12 (2008): 1582-1587. http://www.scopus.com/inward/record.url?eid=2-s2.0-57049160362&partnerID=MN8TOARS.
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  183. Cranenburg, E.C.M.; Vermeer, C.; Koos, R.; Boumans, M.-L.; Hackeng, T.M.; Bouwman, F.G.; Kwaijtaal, M.; et al. "The circulating inactive form of matrix Gla protein (ucMGP) as a biomarker for cardiovascular calcification". Journal of Vascular Research 45 5 (2008): 427-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-50349101161&partnerID=MN8TOARS.
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  184. Vanschoonbeek, K.; Wouters, K.; Van Der Meijden, P.E.J.; Van Gorp, P.J.; Feijge, M.A.H.; Herfs, M.; Schurgers, L.J.; et al. "Anticoagulant effect of dietary fish oil in hyperlipidemia. A study of hepatic gene expression in APOE2 knock-in mice". Arteriosclerosis, Thrombosis, and Vascular Biology 28 11 (2008): 2023-2029. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449109528&partnerID=MN8TOARS.
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  185. Rennenebrg, R.J.M.W.; Schurgers, L.J.; Vermeer, C.; Scholte, J.B.J.; Houben, A.J.H.M.; de Leeuw, P.W.; Kroon, A.A.. "Renal handling of matrix gla-protein in humans with moderate to severe hypertension". Hypertension Research 31 9 (2008): 1745-1751. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449104039&partnerID=MN8TOARS.
  186. van Summeren, M.J.H.; Vermeer, C.; Engelbert, R.H.H.; Schurgers, L.J.; Takken, T.; Fischer, K.; Kuis, W.. "Extremes in vitamin K status of bone are related to bone ultrasound properties in children with juvenile idiopathic arthritis". Clinical and Experimental Rheumatology 26 3 (2008): 484-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949117141&partnerID=MN8TOARS.
  187. van Summeren, M.J.H.; van Coeverden, S.C.C.M.; Schurgers, L.J.; Braam, L.A.J.L.M.; Noirt, F.; Uiterwaal, C.S.P.M.; Kuis, W.; Vermeer, C.. "Vitamin K status is associated with childhood bone mineral content". British Journal of Nutrition 100 4 (2008): 852-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-51749087717&partnerID=MN8TOARS.
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  188. Schurgers, L.J.; Spronk, H.M.H.; Soute, B.A.M.; Schiffers, P.M.; DeMey, J.G.R.; Vermeer, C.. "Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats". Blood 109 7 (2007): 2823-2831. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947578745&partnerID=MN8TOARS.
    10.1182/blood-2006-07-035345
  189. Cario-Toumaniantz, C.; Boularan, C.; Schurgers, L.J.; Heymann, M.-F.; Le Cunff, M.; Léger, J.; Loirand, G.; Pacaud, P.. "Identification of differentially expressed genes in human varicose veins: Involvement of matrix Gla protein in extracellular matrix remodeling". Journal of Vascular Research 44 6 (2007): 444-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648995843&partnerID=MN8TOARS.
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  190. Göritz, C.; Thiebaut, R.; Tessier, L.-H.; Nieweg, K.; Moehle, C.; Buard, I.; Dupont, J.-L.; et al. "Glia-induced neuronal differentiation by transcriptional regulation". GLIA 55 11 (2007): 1108-1122. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547647487&partnerID=MN8TOARS.
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  191. Knapen, M.H.J.; Schurgers, L.J.; Vermeer, C.. "Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women". Osteoporosis International 18 7 (2007): 963-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250003777&partnerID=MN8TOARS.
    10.1007/s00198-007-0337-9
  192. Cranenburg, E.C.M.; Schurgers, L.J.; Vermeer, C.. "Vitamin K: The coagulation vitamin that became omnipotent". Thrombosis and Haemostasis 98 1 (2007): 120-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447521886&partnerID=MN8TOARS.
    10.1160/TH07-04-0266
  193. Schurgers, L.J.; Spronk, H.M.H.; Skepper, J.N.; Hackeng, T.M.; Shanahan, C.M.; Vermeer, C.; Weissberg, P.L.; Proudfoot, D.. "Post-translational modifications regulate matrix Gla protein function: Importance for inhibition of vascular smooth muscle cell calcification". Journal of Thrombosis and Haemostasis 5 12 (2007): 2503-2511. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348941029&partnerID=MN8TOARS.
    10.1111/j.1538-7836.2007.02758.x
  194. Gheduzzi, D.; Boraldi, F.; Annovi, G.; DeVincenzi, C.P.; Schurgers, L.J.; Vermeer, C.; Quaglino, D.; Pasquali Ronchetti, I.. "Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients". Laboratory Investigation 87 10 (2007): 998-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548779758&partnerID=MN8TOARS.
    10.1038/labinvest.3700667
  195. Van Langendonckt, A.; Punyadeera, C.; Kamps, R.; Dunselman, G.; Klein-Hitpass, L.; Schurgers, L.J.; Squifflet, J.; Donnez, J.; Groothuis, P.. "Identification of novel antigens in blood vessels in rectovaginal endometriosis". Molecular Human Reproduction 13 12 (2007): 875-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549033840&partnerID=MN8TOARS.
    10.1093/molehr/gam073
  196. Schurgers, L.J.; Teunissen, K.J.F.; Hamulyák, K.; Knapen, M.H.J.; Vik, H.; Vermeer, C.. "Vitamin K-containing dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7". Blood 109 8 (2007): 3279-3283. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147137917&partnerID=MN8TOARS.
    10.1182/blood-2006-08-040709
  197. Li, Q.; Jiang, Q.; Schurgers, L.J.; Uitto, J.. "Pseudoxanthoma elasticum: Reduced ¿-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-)". Biochemical and Biophysical Research Communications 364 2 (2007): 208-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448993299&partnerID=MN8TOARS.
    10.1016/j.bbrc.2007.09.122
  198. Willems, H.P.J.; Den Heijer, M.; Gerrits, W.B.J.; Schurgers, L.J.; Havekes, M.; Blom, H.J.; Bos, G.M.J.. "Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration". European Journal of Internal Medicine 17 2 (2006): 120-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144465353&partnerID=MN8TOARS.
    10.1016/j.ejim.2005.10.009
  199. Vermeer, C.; Braam, L.; Knapen, M.; Schurgers, L.. "Vitamin K supplements: Unknown effects for bones and the cardiovascular system,Supplémentation en vitamine K: Des effets méconnus pour l'os et le système cardiovasculaire". Phytotherapie 4 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33646012961&partnerID=MN8TOARS.
    10.1007/s10298-006-0135-0
  200. Janzen, J.; Schurgers, L.J.; Vermeer, C.; Joris, F.; Musy, J.-P.; Schmidli, J.. "Aneurysm with mediacalcifications in the aortic arch,Mediakalzifikationen in einem aneurysma des arcus aortae". Perfusion 19 7-8 (2006): 237-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750099140&partnerID=MN8TOARS.
  201. Thijssen, H.H.W.; Vervoot, L.M.T.; Schurgers, L.J.; Shearer, M.J.. "Menadione is a metabolite of oral vitamin K". British Journal of Nutrition 95 2 (2006): 260-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644921501&partnerID=MN8TOARS.
    10.1079/BJN20051630
  202. Schurgers, L.J.; Teunissen, K.J.F.; Knapen, M.H.J.; Geusens, P.; Van Der Heijde, D.; Kwaijtaal, M.; Van Diest, R.; Ketteler, M.; Vermeer, C.. "Characteristics and performance of an immunosorbent assay for human matrix Gla-protein". Clinica Chimica Acta 351 1-2 (2005): 131-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-9444298992&partnerID=MN8TOARS.
    10.1016/j.cccn.2004.08.003
  203. Demir, A.Y.; Groothuis, P.G.; Dunselman, G.A.J.; Schurgers, L.; Evers, J.L.H.; De Goeij, A.F.P.M.. "Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells". Cell and Tissue Research 322 2 (2005): 299-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944476012&partnerID=MN8TOARS.
    10.1007/s00441-005-0002-6
  204. Schurgers, L.J.; Teunissen, K.J.F.; Knapen, M.H.J.; Kwaijtaal, M.; Van Diest, R.; Appels, A.; Reutelingsperger, C.P.; Cleutjens, J.P.M.; Vermeer, C.. "Novel conformation-specific antibodies against matrix ¿- carboxyglutamic acid (Gla) protein: Undercarboitylated matrix Gla protein as marker for vascular calcification". Arteriosclerosis, Thrombosis, and Vascular Biology 25 8 (2005): 1629-1633. http://www.scopus.com/inward/record.url?eid=2-s2.0-23244458678&partnerID=MN8TOARS.
    10.1161/01.ATV.0000173313.46222.43
  205. Schurgers, L.J.; Shearer, M.J.; Hamulyák, K.; Stöcklin, E.; Vermeer, C.. "Effect of vitamin K intake on the stability of oral anticoagulant treatment: Dose-response relationships in healthy subjects". Blood 104 9 (2004): 2682-2689. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244258903&partnerID=MN8TOARS.
    10.1182/blood-2004-04-1525
  206. Schurgers, L.J.; Aebert, H.; Vermeer, C.; Bültmann, B.; Janzen, J.. "Oral anticoagulant treatment: Friend or foe in cardiovascular disease?". Blood 104 10 (2004): 3231-3232. http://www.scopus.com/inward/record.url?eid=2-s2.0-8644252020&partnerID=MN8TOARS.
    10.1182/blood-2004-04-1277
  207. Ryan, B.M.; Russel, M.G.V.M.; Schurgers, L.; Wichers, M.; Sijbrandij, J.; Stockbrugger, R.W.; Schoon, E.. "Effect of antitumour necrosis factor-a therapy on bone turnover in patients with active Crohn's disease: A prospective study". Alimentary Pharmacology and Therapeutics 20 8 (2004): 851-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-7044224181&partnerID=MN8TOARS.
    10.1111/j.1365-2036.2004.02097.x
  208. Kobayashi, N.; Kitazawa, R.; Maeda, S.; Schurgers, L.J.; Kitazawa, S.. "T-138C polymorphism of matrix Gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification". Kobe Journal of Medical Sciences 50 3-4 (2004): 69-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-22444441867&partnerID=MN8TOARS.
  209. Geleijnse, J.M.; Vermeer, C.; Grobbee, D.E.; Schurgers, L.J.; Knapen, M.H.J.; Van Der Meer, I.M.; Hofman, A.; Witteman, J.C.M.. "Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study". Journal of Nutrition 134 11 (2004): 3100-3105. http://www.scopus.com/inward/record.url?eid=2-s2.0-7944233489&partnerID=MN8TOARS.
  210. Reynolds, J.L.; Joannides, A.J.; Skepper, J.N.; Mcnair, R.; Schurgers, L.J.; Proudfoot, D.; Jahnen-Dechent, W.; Weissberg, P.L.; Shanahan, C.M.. "Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD". Journal of the American Society of Nephrology 15 11 (2004): 2857-2867. http://www.scopus.com/inward/record.url?eid=2-s2.0-14544283020&partnerID=MN8TOARS.
    10.1097/01.ASN.0000141960.01035.28
  211. Spronk, H.M.H.; Soute, B.A.M.; Schurgers, L.J.; Thijssen, H.H.W.; De Mey, J.G.R.; Vermeer, C.. "Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats". Journal of Vascular Research 40 6 (2003): 531-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-0442293394&partnerID=MN8TOARS.
    10.1159/000075344
  212. Ketteler, M.; Wanner, C.; Metzger, T.; Bongartz, P.; Westenfeld, R.; Gladziwa, U.; Schurgers, L.J.; et al. "Deficiencies of calcium-regulatory proteins in dialysis patients: A novel concept of cardiovascular calcification in uremia". Kidney International, Supplement 63 84 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-1842513889&partnerID=MN8TOARS.
  213. Vermeer, C.; Braam, L.; Knapen, M.; Schurgers, L.. "Vitamin K supplementation: A simple way to improve bone and vascular health". Agro Food Industry Hi-Tech 14 6 (2003): 17-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242288031&partnerID=MN8TOARS.
  214. Vermeer, C.; Braam, L.; Schurgers, L.; Brouns, F.. "Increased vitamin K intake by functional foods or food supplements: A new lead to improve cardiovascular and bone health". Agro Food Industry Hi-Tech 13 5 (2002): 11-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036762726&partnerID=MN8TOARS.
  215. Schurgers, L.J.; Shearer, M.J.; Soute, B.A.M.; Elmadfa, I.; Harvey, J.; Wagner, K.-H.; Tomasch, R.; Vermeer, C.. "Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men". Journal of Lipid Research 43 6 (2002): 878-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035988341&partnerID=MN8TOARS.
  216. Celie, P.H.N.; Van Stempvoort, G.; Fribourg, C.; Schurgers, L.J.; Lenting, P.J.; Mertens, K.. "The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain". Journal of Biological Chemistry 277 23 (2002): 20214-20220. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037036401&partnerID=MN8TOARS.
    10.1074/jbc.M108446200
  217. Schurgers, L.J.; Vermeer, C.. "Differential lipoprotein transport pathways of K-vitamins in healthy subjects". Biochimica et Biophysica Acta - General Subjects 1570 1 (2002): 27-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037084981&partnerID=MN8TOARS.
    10.1016/S0304-4165(02)00147-2
  218. Spronk, H.M.H.; Soute, B.A.M.; Schurgers, L.J.; Cleutjens, J.P.M.; Thijssen, H.H.W.; De Mey, J.G.R.; Vermeer, C.. "Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall". Biochemical and Biophysical Research Communications 289 2 (2001): 485-490. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035976773&partnerID=MN8TOARS.
    10.1006/bbrc.2001.5996
  219. Schoon, E.J.; Müller, M.C.A.; Vermeer, C.; Schurgers, L.J.; Brummer, R.-J.M.; Stockbrügger, R.W.. "Low serum and bone vitamin K status in patients with longstanding Crohn's disease: Another pathogenetic factor of osteoporosis in Crohn's disease?". Gut 48 4 (2001): 473-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035080001&partnerID=MN8TOARS.
    10.1136/gut.48.4.473
  220. Schurgers, L.J.; Dissel, P.E.P.; Spronk, H.M.H.; Soute, B.A.M.; Dhore, C.R.; Cleutjens, J.P.M.; Vermeer, C.. "Role of vitamin K and vitamin K-dependent proteins in vascular calcification". Zeitschrift fur Kardiologie 90 (2001): 57-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035075742&partnerID=MN8TOARS.
  221. Schurgers, L.J.; Vermeer, C.. "Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport". Journal of Lipid Research 42 7 (2001): 1120-1124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034953223&partnerID=MN8TOARS.
  222. Schoon, E.J.; Geerling, B.G.; Van Dooren, I.M.A.; Schurgers, L.J.; Vermeer, C.; Brummer, R.-J.M.; Stockbrügger, R.W.. "Abnormal bone turnover in long-standing Crohn's disease in remission". Alimentary Pharmacology and Therapeutics 15 6 (2001): 783-792. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034990684&partnerID=MN8TOARS.
    10.1046/j.1365-2036.2001.00997.x
  223. Vermeer, C.; Schurgers, L.J.. "A comprehensive review of vitamin K and vitamin K antagonists". Hematology/Oncology Clinics of North America 14 2 (2000): 339-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034011505&partnerID=MN8TOARS.
    10.1016/S0889-8588(05)70137-4
  224. Oldenburg, J.; Von Brederlow, B.; Fregin, A.; Rost, S.; Wolz, W.; Eberl, W.; Eber, S.; et al. "Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex". Thrombosis and Haemostasis 84 6 (2000): 937-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034530536&partnerID=MN8TOARS.
  225. Schurgers, L.J.; Vermeer, C.. "Determination of phylloquinone and menaquinones in food: Effect of food matrix on circulating vitamin K concentrations". Haemostasis 30 6 (2000): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034445265&partnerID=MN8TOARS.
  226. Koivu-Tikkanen, T.J.; Schurgers, L.J.; Thijssen, H.H.W.; Vermeer, C.. "Intestinal, hepatic, and circulating vitamin K levels at low and high intakes of vitamin K in rats". British Journal of Nutrition 83 2 (2000): 185-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033960722&partnerID=MN8TOARS.
  227. Indyk, H.E.; Woollard, D.C.; Barber, M.; Berge, C.; Booth, S.; Burn, M.; Cecco, A.; et al. "Determination of Vitamin K in Milk and Infant Formulas by Liquid Chromatography: Collaborative Study". Journal of AOAC International 83 1 (2000): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033630972&partnerID=MN8TOARS.
  228. Schurgers, L.J.; Geleijnse, J.M.; Grobbee, D.E.; Pols, H.A.P.; Hofman, A.; Witteman, J.C.M.; Vermeer, C.. "Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in the Netherlands". Journal of Nutritional and Environmental Medicine 9 2 (1999): 115-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033063620&partnerID=MN8TOARS.
    10.1080/13590849961717
  229. Vermeer, C.; Knapen, M.H.J.; Schurgers, L.J.. "Vitamin K and metabolic bone disease". Journal of Clinical Pathology 51 6 (1998): 424-426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031809227&partnerID=MN8TOARS.
    10.1136/jcp.51.6.424
  230. Schoon, E.J.; Geerling, B.; Schurgers, L.; Vermeer, C.; Russel, M.G.; Stockbrügger, R.W.; Brum, R.-J.. "Suppressed bone formation but normal bone resorption in long-standing quiescent crohn’s disease". European Journal of Gastroenterology and Hepatology 10 12 (1998): A16-A16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026152263&partnerID=MN8TOARS.
    10.1097/00042737-199812000-00070
Thesis / Dissertation
  1. "Studies on the role of vitamin K1 and K2 in bone metabolism and cardiovascular disease : structural differences determine different metabolic pathways". 2002. https://cris.maastrichtuniversity.nl/en/publications/c1210808-c49e-4c65-ac8d-23a893ce4ce8.
    10.26481/dis.20020621ls

Intellectual property

Patent
  1. Schurgers, Leon. 2006. "Pharmaceutical and nutraceutical products comprising vitamin K2".
    Allowed

Other

Other output
  1. Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19. 2020. Anton S.M. Dofferhoff; Ianthe Piscaer; Leon J. Schurgers; Jona Walk; Jody M.W. van den Ouweland; Tilman M. Hackeng; Pim A. de Jong; et al. https://doi.org/10.20944/preprints202004.0457.v2.
    10.20944/preprints202004.0457.v2
  2. Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19. 2020. Anton S.M. Dofferhoff; Ianthe Piscaer; Leon J. Schurgers; Jona Walk; Jody M.W. van den Ouweland; Tilman M. Hackeng; Petra Lux; et al. https://doi.org/10.20944/preprints202004.0457.v1.
    10.20944/preprints202004.0457.v1
  3. MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. 2019. Kim van Kuijk; T. Theelen; J. Demandt; E. Marsch; Marion Gijbels; H. Jin; C. Reutelingsperger; et al. https://cris.maastrichtuniversity.nl/en/publications/dbf2a79b-6afb-4804-967a-391b1ceaddb6.
    10.1016/j.atherosclerosis.2019.06.027
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Heart Valve Society VAE 2020
2020 7th Annual Stem Cell Science Symposium
2020 ERA-EDTA European renal Osteodystrophy (EUROD) winter meeting Leuven
2019 Vascular inflammation, calcification and fibrosis: Role for vascular smooth muscle cell phenotypic switching MCCT Maastricht 2019
2019 Cardiovascular Calcification: how to prevent and treat Sao Paulo Cardiology meeting 2019
2019 Vascular calcification: Innocent bystander or culprit risk factor? State of the art lecture Glasgow ECTH 2019
2019 Meet the expert Glasgow ECTH 2019
2019 Calcification and treatment with vitamin K antagonists NVTH PHD course 2019
2019 The Netherlands Heart Institute Thema middag
2018 Hard disease and the vasculature: rocking between epidemiological clinical and basic science. 2nd Translation Cardiovascular Research Meeting - The Netherlands Heart Institute
2018 Exosome-mediated vascular calcification ESC Munich 2018
2018 Clinical consequence of vitamin K deficiency New York 2018
2018 Vitamin K and vascular ageing mechanisms Workshop INTRICARE Stockholm 2018
2018 Vascular calcification: a modifiable risk factor Workshop CaReSyAn Frankfurt 2018
2018 Effects of vitamin K and vitamin K antagonists on arterial calcification and vascular stiffening 11th international workshop on structure and function of the vascular system.
2017 Role of Vitamin K in vascular calcifications Lebanese Nephrology congress
2017 Role of Vitamin K in arterial calcifications and cardiovascular diseases Pisa Artery congress
2017 Vitamin K-deficiency – does it promote vascular calcification ERA EDTA symposium Madrid
2016 Clinical consequeces of vitamin K deficiency ASN symposium Chicago
2016 The infernal triad: matrix Gla protein, vitamin K and vascular calcification ERA EDTA symposium
2016 Vascular calcification: from innocent bystander to culprit riskfactor Program NCCS Workshop in Pune
2015 Vitamin K: Connection between coagulation and calcification Aachen 2015. HIA and DGBM symposium
2015 Vascular calcification: from innocent bystander to culprit risk factor Aachen 2015 Cardiovascular seminar “IMCARIM”
2015 Menaquinone-7 – a novel treatment option for cardiovascular disease Las Vegas Supply Side West 2015
2015 Vascular calcification: The price to pay for anticoagulation with vitamin K-antagonists GHSSH Bern 2015
2015 Finding Calcium in the non-calcified atherosclerotic lesion: insight into atheroma evolution using preclinical and clinical approaches CARIM dag 2015
2015 Vascular smooth muscle cell mediated calcification Cologne, Cardiovascular seminar 2015
2015 Vitamin K and Calcification FASEB, Vitamin K meeting Chigago 2015
2015 Vascular calcification: from innocent bystander to culprit risk factor Grand Rounds Carim 2015
2015 Deficiency of calcification inhibitors Calcyphylaxis expert meeting Leuven, 2015
2015 Vascular calcification: from innocent bystander to culprit risk factor DGAF, Raichholzhauzen 2015
2014 Vascular calcification: The price to pay for anticoagulation with vitamin K-antagonists Krakow 2014 (Jagiellonian Centre for Experimental Therapeutics)
2014 Vitamin K-antagonists: A two edged sword bi-phasic effect of VKA on atherosclerotic plaque development Longyearbyen 2014, Norway (1st Venous thrombosis meeting)
2014 Vitamin K and Vascular calcification: new treatment options? NMRD 2014 Wurzburg
2014 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists GTH 2014 Vienna
2013 Vascular smooth muscle cell phenotypic switching: importance for vascular calcification Cardiovascular Network Retreat, Rauischholzhausen 2013
2012 Strategies for prevention and regression of vascular calcification: new treatment options? ECS 2012 Munich
2012 Vascular calcification: new treatment options? ECS 2012 Munich
2012 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists Grand Rounds Carim 2012
2012 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists NIGRAM 2012
2011 The role of vitamin K and vitamin K-dependent proteins in the arterial vessel wall NVTH 2011 The Netherlands
2011 The role of vitamin K in arterial calcification FASEB 2011 Arizona
2011 Vascular Calcification Abbott 2011 Barcelona
2011 Role of vitamin K in vascular calcification GTH 2011 Wiesbaden
2010 Vascular calcifications as a risk factor for cardiovascular mortality ERA-EDTA Munich, 2010
2010 Vascular calcification in Dialysis: modulated by vitamin K-status?
Belgium Nephrology symposium 2010
2010 Vascular calcification in Chronic Kidney Disease: importance of vitamin K-status Dutch Nephrology symposium 2010
2008 Vitamin K: a modifiable risk factor” American Society of Nephrology 2008. Plenary lecture
2008 MGP: the calcification inhibitor in need of vitamin K” Angers, France 2008
2008 MGP and Vitamin K: importance for vascular health” 2008 Sendai (Japan)
2007 “Function of vitamin K and MGP in pseudoxanthoma elastica” EuroPXE, Budapest, 2007
2006 Vitamin K2: cardiovascular and bone health benefits beyond K1” Supply Side East, New Jersey 2006
2002 Vitamin K: Friend or foe in cardiovascular disease Tübingen 2002
2002 Oral anticoagulants: Friend or foe in cardiovascular disease XVIth International Symposium on Haemostasis, Cairo, January 5-9, 2002
2001 Differential metabolic pathways for K-vitamins. FASEB Summer Research Conference on Vitamin K, Saxtons River, USA. 2001
2001 Differential metabolic pathways for K-vitamins in vascular calcification Workshop on vascular calcification. 2001. Wittenberg, Germany
2001 Potential involvement of vitamin K-dependent Matrix Gla-Protein (MGP) in ectopic calcification XIVth Aachen Colloquim on Biomaterials. 2001
2000 Role of vitamin K in vascular calcification Workshop on vascular calcification. 2000. Wittenberg, Germany
1999 Relationship of vitamin K intake to bone health Vitamins A & K Workshop, organized by the Panel on Micronutrients, Food and Nutrition Board, National Academy of Sciences Institute of Medicine, Washington, USA, 1999

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - Current Role of vascular smooth muscle cell mediated calcification in atherosclerosis
Co-supervisor
2015 - Current Annexin A1 and annexin A5 in cardiovascular disease
Co-supervisor
2013 - Current Phosphatidylserine targeting for diagnosis and treatment of human diseases
Co-supervisor
2011 - Current Vascular calcifications and Matrix Gla Protein in Hypertensive Subjects
Co-supervisor
2011 - Current Development and validation of circulating matrix Gla-protein as biomarker for vascular disease: a modifiable inhibitor of vascular calcification
Co-supervisor

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015 - Current Organizing Committee of the FASEB summer course on vitamin K (Chicago, 2015) (2015)
Other (Member of the Scientific Committee)
2015 - 2015 Organizing Committee of the 8th international Annexin Conference (Maastricht, 2015) (2015)
Conference (Member of the Scientific Committee)

Association member

Society Organization name Role
2019/01/01 - 2020 American Society of Nephrology Member

Committee member

Activity description
Role 		Institution / Organization
2001 - Current Member of the Nederlandse Vereniging voor Thrombose en Hemostase
Member
1999 - Current Member of the International Society for Thrombosis and Haemostasis (ISTH)
Member
2001 - 2007 American Society of Bone and Mineral Research
Member
2001 - 2005 American Heart Association
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017 - Current Coordinator Geneeskunde blok 1.5 Verteer en Verweer FHML (GEN, vice-coordinator ITM) Maastricht Universitair Medisch Centrum+, Netherlands
2017 - Current Tutor and lecturer Block 2.6
2011 - Current Coordinator pre-medicine Course Biochemistry (UCM)
2011 - Current Tutor Medicine Course 1.5 (ITM and regular)
2015 - 2017 Coordinator Medicine Course 1.5 Digestion and Defense FHML (ITM, vice-coordinator GEN)

Journal scientific committee

Journal title (ISSN) Publisher
2015 - Current Nutrients (2072-6643) MDPI AG
Distinctions

Award

2019 CARIM Seed grant with University California Irvine (UCI) to establish a collaboration on the role of vitamin K dependent MGP and arteriovenous malformations (AVM)
2019 Rogier Veltrop – CARIM HS-BAFTA award (6 month travel grant)
2019 Asim Cengiz Akbulut – CARIM HS-BAFTA award (6 month travel grant)
2017 2017 Maurice Halder – Unilever Research Price 2017 “Arterial remodeling: a key player in cardiovascular disease” Master student
2017 2017 Rick van Gorp – Best Poster price CARIM symposium
2017 2017 Rick van Gorp – Abstract price NVTH
2016 2016 Martijn Chatrou – Thesis dissertation price CARIM
2015 2015 Rick van Gorp – Abstract Price NVTH