???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Leon Schurgers

Nomes de citação

  • Schurgers, Leon

Identificadores de autor

Ciência ID
7217-439E-10AB
ORCID iD
0000-0001-7867-6957
Formação
Grau Classificação
2011 - 2012
Concluído
 Basic teaching qualification course (Laurea Specialistica)
Maastricht Universitair Medisch Centrum+, Países Baixos
1998/08/01 - 2002/06/21
Concluído
 PhD (Doktor (PhD))
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
"STUDIES ON THE ROLE OF VITAMIN K1 AND K2 IN BONE METABOLISM AND CARDIOVASCULAR DISEASE" (TESE/DISSERTAÇÃO)
1990/09/01 - 1995/06/28
Concluído
 Hematology and Clinical Chemistry at University of Applied Science (Bachelor)
Zuyd Hogeschool, Países Baixos
"STUDIES ON THE ROLE OF VITAMIN K1 AND K2 IN BONE METABOLISM AND CARDIOVASCULAR DISEASE" (TESE/DISSERTAÇÃO)
 BSc
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2009/01/01 - Atual Investigador principal (carreira) (Investigação) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2002/06/21 - 2008/12/31 Gestão de Ciência e Tecnologia Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
1995 - 1998 Assistente de Investigação (carreira) (Investigação) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Professor Catedrático (Docente Universitário) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
Maastricht Universitair Medisch Centrum+, Países Baixos
2011 - 2014 Assistente (Docente Universitário) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Vice chair department of Biochemistry Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
Maastricht Universitair Medisch Centrum+, Países Baixos
(...)
2017 - Atual Board member of MosaCell, a platform for patient derived cells for disease modeling Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2015 - Atual Scientific advisor of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2013 - Atual Head of the central centrifuge facility MUMC+ Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2014 - 2017 Tenured associate Professor of Biochemistry Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2009 - 2015 Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2009 - 2011 Half-time Assistant Professor of Biochemistry, CARIM, Maastricht University and half-time vice president R&D VitaK, Maastricht University Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2003 - 2009 Scientific Director for the world-wide quality assurance scheme for vitamin K-detection (KEQAS) Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos
2002 - 2009 Senior researcher at VitaK, Maastricht University Universiteit Maastricht Cardiovascular Research Institute Maastricht, Países Baixos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - 2027 Member of the scientific advisory board of the Dutch Thrombosis society Dutch Thrombosis society, Alemanha
2013 - 2019 Vice-president experimental animal committee Maastricht University Universiteit Maastricht, Países Baixos
2013 - 2019 Member of the scientific advisory board of the Dutch Kidney foundation Dutch Kidney foundation, Alemanha
2013 - 2019 Treasurer of the Dutch Thrombosis society Dutch Thrombosis society, Alemanha
2015 - 2018 Member of the annual monitoring committee of the Life Sciences and Health (LSH) impulse programme of ZonMW ZonMw, Países Baixos
2012 - 2016 Scientific advisor of the Dutch NIGRAM consortium grant Dutch NIGRAM, Alemanha
Projetos

Bolsa

Designação Financiadores
2020 - 2022 RegMedXB – Moonshot Cardiovascular
RegMedXB
Investigador responsável
Em curso
2020 - 2022 Pro-calcifying properties of vitamin K antagonists and potential protective role of Rivaroxaban in the cardiovascular system
Bayer
Investigador
Bayer AG
Em curso
2019 - 2022 Thrombo-Inflammation in CARDIOvascular disease (TICARDIO)
TICARDIO
Investigador responsável
Em curso
2018 - 2021 Combatting the CardioRenal Syndrome: towards an integrative Analysis to reduce cardiovascular burden in chronic kidney disease (CaReSyAn)
CaReSyAn
Investigador responsável
Em curso
2019 - 2020 Small vessels, big problems: the role of MGP and Alk1 in vascular malformations
Small vessels, big problems
Investigador
Universiteit Maastricht Cardiovascular Research Institute Maastricht
Em curso
2017 - 2020 International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE (INTRICARE)
INTRICARE
Investigador responsável
Concluído
2016 - 2019 European Vascular Interventions and Therapeutic Innovation Network (EVOLuTION; 675111)
EVOLuTION; 675111
Investigador
Concluído
2014 - 2018 Effects of vitamin K-antagonists, vitamin K and new oral anticoagulants on atherogenesis. Trombose Stichting Nederland; 2014-02)
Trombose Stichting Nederland; 2014-02
Investigador responsável
Universiteit Maastricht, Países Baixos
Concluído
2014 - 2018 The role of vitamin K2 (MK7) on vitamin K-dependent proteins and their effect on bone and vascular calcification. Project 241584
Project 241584
Investigador responsável
Concluído
2017 - 2017 Imaging atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2017
Investigador responsável
Boehringer Ingelheim Animal Health
Concluído
2014 - 2017 The VitaVasK study: Vitamin K1 to Slow Vascular Calcification in Hemodialysis Patients. European Renal Association
VitaVasK study
Investigador
Clinical Trial Center Maastricht, Países Baixos
 European Dialysis and Transplant Nurses Association/European Renal Care Association
Concluído
2014 - 2017 BRAEDEN: a BioHybrid platform Replacing Animal Experiments for Drug Efficacy iNvestigations
BRAEDEN
Investigador
Concluído
2012 - 2012 UMouse: reporter mouse for vascular smooth muscle cell health in vivo (2012)
UMouse
Investigador responsável
Maastricht Universitair Medisch Centrum+, Países Baixos
Concluído
2006 - 2011 Menaquinone-7 as dietary supplement to prevent bone loss and vascular calcification
VitaK BV
Investigador
Clinical Trial Center Maastricht, Países Baixos
Concluído

Projeto

Designação Financiadores
2002 - Atual Vascular smooth muscle cells and vascular calcification
#16, 28, 36, 64, 84, 95, 121, 140
Bolseiro de Cientista Convidado
British Heart Foundation, Reino Unido
Em curso

Outro

Designação Financiadores
2013 - Atual Vitamin K2 and cardiovascular healthy
NattoPharma2013
Investigador responsável
Maastricht Universitair Medisch Centrum+, Países Baixos
Em curso
2006 - Atual Chronic kidney disease and vascular calcification
#13, 47, 51, 55, 58, 66, 79, 90, 105, 114, 130, 137
Bolseiro de Integração na Investigação
Deutsche Forschungsgemeinschaft, Alemanha
Em curso
2006 - Atual Mutations in ABCC6 resulting in PXE and elastin calcification
#25, 48, 49, 81, 106, 107, 113
Em curso
2001 - Atual Vitamin K detection
#11, 18, 59, 89, 108, 128
Bolseiro de Integração na Investigação
Em curso
2001 - Atual Endogenous inhibitors of arterial calcification
#16, 51, 90, 95, 105, 111
Bolseiro de Integração na Investigação
Em curso
2017 - 2021 The role of vitamin K2 (MK7) on the calcium paradox. Project 241584
Project 241584
Investigador responsável
Em curso
2015 - 2015 Imaging atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2015
Investigador responsável
Maastricht Universitair Medisch Centrum+, Países Baixos
 Boehringer Ingelheim Animal Health
Concluído
2013 - 2013 Comparative study of effects of Dabigatran and Warfarin on atherosclerotic plaque calcification. A comparative study in the apoE-/- mouse model of atherosclerosis
Boehringer Ingelheim2013
Investigador responsável
Maastricht Universitair Medisch Centrum+, Países Baixos
 Boehringer Ingelheim Animal Health
Concluído
Produções

Publicações

Artigo em revista
  1. Stefanos Roumeliotis; Vassilios Liakopoulos; Leon J. Schurgers. "Vitamin K supplementation in chronic kidney disease patients: where is the evidence?". Current Vascular Pharmacology (2022): https://doi.org/10.2174/1570161120666220209145341.
    10.2174/1570161120666220209145341
  2. Nicoline H J Leenders; Caro Bos; Tiny Hoekstra; Leon J Schurgers; Marc G Vervloet; Joost G J Hoenderop. "Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease". Nephrology Dialysis Transplantation (2022): https://doi.org/10.1093/ndt/gfac026.
    10.1093/ndt/gfac026
  3. Dawid M. Kaczor; Rafael Kramann; Tilman M. Hackeng; Leon J. Schurgers; Rory R. Koenen. "Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23020580.
    10.3390/ijms23020580
  4. Rachid Tobal; Judith Potjewijd; Vanessa P M van Empel; Renee Ysermans; Leon Schurgers; Chris P Reutelingsperger; Jan Damoiseaux; Pieter van Paassen. "Vascular Remodeling in Pulmonary Arterial Hypertension". Frontiers in medicine 8 (2021): 806899-806899. https://cris.maastrichtuniversity.nl/en/publications/7f6bddd8-e430-44b3-957d-bbdd1a3d2bb4.
    10.3389/fmed.2021.806899
  5. Anton S M Dofferhoff; Ianthe Piscaer; Leon Schurgers; Margot P J Visser; Jody M W van den Ouweland; Pim A de Jong; Reinoud Gosens; et al. "Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019". Clinical Infectious Diseases 73 11 (2021): E4039-E4046. https://cris.maastrichtuniversity.nl/en/publications/c97e2958-f726-4191-91d4-2a8dd777ea19.
    10.1093/cid/ciaa1258
  6. Dion Groothof; Adrian Post; Camilo G Sotomayor; Charlotte A Keyzer; Jose L Flores-Guerero; Eelko Hak; Jens H J Bos; et al. "Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria". Nephrology Dialysis Transplantation 36 12 (2021): 2290-2299. https://cris.maastrichtuniversity.nl/en/publications/358bb37d-5d1a-45fa-909c-811aeb00f6b1.
    10.1093/ndt/gfaa304
  7. N. Kaesler; Leon Schurgers; J. Floege. "Vitamin K and cardiovascular complications in chronic kidney disease patients". Kidney International 100 5 (2021): 1023-1036. https://cris.maastrichtuniversity.nl/en/publications/1b71c438-eead-40b3-b8c7-5d3cc785819c.
    10.1016/j.kint.2021.06.037
  8. E. Hariri; N. Kassis; J.P. Iskandar; Leon Schurgers; A. Saad; O. Abdelfattah; A. Bansal; et al. "Vitamin K-2-a neglected player in cardiovascular health: a narrative review". Open Heart 8 2 (2021): https://cris.maastrichtuniversity.nl/en/publications/63a57381-ba58-4a3f-ba61-bb28aee9f2bc.
    10.1136/openhrt-2021-001715
  9. Alexandru Florea; Agnieszka Morgenroth; Jan Bucerius; Leon Schurgers; Felix Mottaghy. "Locking and loading the bullet against micro-calcification". European Journal of Preventive Cardiology 28 12 (2021): 1370-1375. https://cris.maastrichtuniversity.nl/en/publications/6a84eaec-3b26-4965-8b2d-eff35a32e2a2.
    10.1177/2047487320911138
  10. Aegida Neradova; Grzegorz Wasilewski; Selene Prisco; Peter Leenders; Marjolein Caron; Tim Welting; Bert van Rietbergen; et al. "Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure". Nephrology Dialysis Transplantation (2021): https://cris.maastrichtuniversity.nl/en/publications/cdea6ad0-e6e7-4f1a-a5ae-0e3546ecb817.
    10.1093/ndt/gfab314
  11. Nikolas Rapp; Vincent M. Brandenburg; Nadine Kaesler; Stephan Bakker; Robert Stöhr; Alexander Schuh; Pieter Evenepoel; Leon Schurgers. "Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk". Nutrients (2021): https://www.mdpi.com/2072-6643/13/10/3490.
    10.3390/nu13103490
  12. Daan Kremer; Dion Groothof; Charlotte A. Keyzer; Coby Eelderink; Tim J. Knobbe; Adrian Post; Marco van Londen; et al. "Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies". Nutrients 13 9 (2021): 3069-3069. https://doi.org/10.3390/nu13093069.
    10.3390/nu13093069
  13. Armand Jaminon; Asim C. Akbulut; Niko Rapp; Rafael Kramann; Erik A. L. Biessen; Lieve Temmerman; Barend Mees; et al. "Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity". Cells (2021): https://www.mdpi.com/2073-4409/10/8/2097.
    10.3390/cells10082097
  14. Sofia Dahlberg; Ulf Schött; Emilia Ängeby Eriksson; Yllnor Tahirsylaj; Leon Schurgers; Thomas Kander. "Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study". Nutrients 13 8 (2021): 2580-2580. https://doi.org/10.3390/nu13082580.
    10.3390/nu13082580
  15. Ploingarm Petsophonsakul; Mathias Burgmaier; Brecht Willems; Sylvia Heeneman; Nadina Stadler; Felix Gremse; Sebastian Reith; et al. "Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells". Cardiovascular Research (2021): https://cris.maastrichtuniversity.nl/en/publications/ae7dbf3d-9500-4091-9653-14ad7dfaaf73.
    10.1093/cvr/cvab244
  16. Shaiv Parikh; Berta Ganizada; Gijs Debeij; Ehsan Natour; Jos Maessen; Bart Spronck; Leon Schurgers; et al. "Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta". Biomedicines 9 6 (2021): 670-670. https://doi.org/10.3390/biomedicines9060670.
    10.3390/biomedicines9060670
  17. Lu Dai; Leon Schurgers; Paul G Shiels; Peter Stenvinkel. "A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases". Clinical Science 135 10 (2021): 1251-1272. https://cris.maastrichtuniversity.nl/en/publications/71a540cc-3ec5-4f1d-864e-58de69aab14d.
    10.1042/CS20201452
  18. Michael I. McBurney; Jeffrey Blumberg; Rebecca B. Costello; Manfred Eggersdorfer; John W. Erdman; William S. Harris; Elizabeth J. Johnson; et al. "Beyond Nutrient Deficiency—Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations". Nutrients (2021): https://www.mdpi.com/2072-6643/13/6/1844.
    10.3390/nu13061844
  19. Till Seime; Asim Cengiz Akbulut; Moritz Lindquist Liljeqvist; Antti Siika; Hong Jin; Greg Winski; Rick H. van Gorp; et al. "Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification". Cells (2021): https://www.mdpi.com/2073-4409/10/6/1276.
    10.3390/cells10061276
  20. Rick H van Gorp; Ingrid Dijkgraaf; Vanessa Bröker; Matthias Bauwens; Peter Leenders; Danyel Jennen; Marc R Dweck; et al. "Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate". Journal of Thrombosis and Haemostasis 19 5 (2021): 1348-1363. https://cris.maastrichtuniversity.nl/en/publications/1c7c13ca-b79b-4dae-a5a6-0f9e2425d247.
    10.1111/jth.15289
  21. Kim van Kuijk; J A F Demandt; J Perales-Patón; T L Theelen; C Kuppe; E Marsch; Jenny de Bruijn; et al. "Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling". Cardiovascular Research (2021): https://cris.maastrichtuniversity.nl/en/publications/d474462c-af18-4196-9a1d-f8636126c7e4.
    10.1093/cvr/cvab152
  22. M. Fusaro; G. Cianciolo; P. Evenepoel; Leon Schurgers; M. Plebani. "Vitamin K in CKD Bone Disorders". Calcified Tissue International 108 4 (2021): 476-485. https://cris.maastrichtuniversity.nl/en/publications/5c24281c-894a-4674-94a4-7a21609788b6.
    10.1007/s00223-020-00792-2
  23. Adriana J. van Ballegooijen; Joline W. J. Beulens; Lyanne M. Kieneker; Martin H. de Borst; Ron T. Gansevoort; Ido P. Kema; Leon Schurgers; Marc G. Vervloet; Stephan J. L. Bakker. "Combined low vitamin D and K status amplifies mortality risk". European Journal of Nutrition 60 3 (2021): 1645-1654. https://cris.maastrichtuniversity.nl/en/publications/22cf7f08-0ebd-4b31-8c4e-a516fb855bfe.
    10.1007/s00394-020-02352-8
  24. Alexandru Florea; M. Eline Kooi; Werner Mess; Leon J. Schurgers; Jan Bucerius; Felix M. Mottaghy. "Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[18F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design". Nutrients 13 3 (2021): 994-994. https://doi.org/10.3390/nu13030994.
    10.3390/nu13030994
  25. Lu Dai; Longkai Li; Helen Erlandsson; Armand Jaminon; Abdul Rashid Qureshi; Jonaz Ripsweden; Torkel B Brismar; et al. "Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease". PLOS ONE 16 2 (2021): e0247623-e0247623. https://cris.maastrichtuniversity.nl/en/publications/51a7b6b5-e7d0-4f74-b153-0e7f972be6b9.
    10.1371/journal.pone.0247623
  26. Malgorzata Furmanik; Rick van Gorp; Meredith Whitehead; Sadia Ahmad; Jayanta Bordoloi; Alexander Kapustin; Leon J. Schurgers; Catherine M. Shanahan. "Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles". Arteriosclerosis, Thrombosis, and Vascular Biology 41 2 (2021): 898-914. https://doi.org/10.1161/ATVBAHA.120.315506.
    10.1161/ATVBAHA.120.315506
  27. Alexandru Florea; Julius P. Sigl; Agnieszka Morgenroth; Andreas Vogg; Sabri Sahnoun; Oliver H. Winz; Jan Bucerius; Leon J. Schurgers; Felix M. Mottaghy. "Sodium [18F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment". Cells 10 2 (2021): 275-275. https://doi.org/10.3390/cells10020275.
    10.3390/cells10020275
  28. Zhenyu Hao; Da-Yun Jin; Xuejie Chen; Leon J. Schurgers; Darrel W. Stafford; Jian-Ke Tie. "¿-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins". Blood (2021): https://doi.org/10.1182/blood.2020006329.
    10.1182/blood.2020006329
  29. A.C. Akbulut; G.B. Wasilewski; N. Rapp; F. Forin; H. Singer; K.J. Czogalla-Nitsche; Leon Schurgers. "Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells". Frontiers in Cell and Developmental Biology 8 (2021): https://cris.maastrichtuniversity.nl/en/publications/cbecacd7-752d-4a5e-ab17-34a1b4b1ac42.
    10.3389/fcell.2020.618760
  30. Nikolas Rapp; Pieter Evenepoel; Peter Stenvinkel; Leon Schurgers. "Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees". Toxins 12 10 (2020): 624-624. https://doi.org/10.3390/toxins12100624.
    10.3390/toxins12100624
  31. Malgorzata Furmanik; Martijn Chatrou; Rick van Gorp; Asim Akbulut; Brecht Willems; Harald H. H. W. Schmidt; Guillaume van Eys; et al. "Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification". Circulation Research 127 7 (2020): 911-927. https://cris.maastrichtuniversity.nl/en/publications/6d2b25f6-9107-4d02-ad2e-fb68748635f8.
    10.1161/CIRCRESAHA.119.316159
  32. S.W.P. Haroon; C. Tai; L.H. Ling; L. Teo; A. Davenport; Leon Schurgers; B.W. Teo; et al. "Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK) A study protocol for a randomized controlled trial". Medicine 99 36 (2020): https://cris.maastrichtuniversity.nl/en/publications/0e0c4815-44aa-47af-96b1-1c3e458b2377.
    10.1097/MD.0000000000021906
  33. Sabine R. Zwakenberg; Pim A. de Jong; Eva J. Hendriks; Jan Westerink; Wilko Spiering; Gert J. de Borst; Maarten J. Cramer; et al. "Intimal and medial calcification in relation to cardiovascular risk factors". PLOS ONE 15 7 (2020): https://cris.maastrichtuniversity.nl/en/publications/1dad5c1f-c6e9-44b9-a7c0-181efc2d7f58.
    10.1371/journal.pone.0235228
  34. Frederique E. C. M. Peeters; Dudink EAMP; Bob Weijs; Larissa Fabritz; Winnie Chua; Bas Kietselaer; Joachim Wildberger; et al. "Biomarkers Associated With Aortic Valve Calcification". Frontiers in Cell and Developmental Biology 8 (2020): https://cris.maastrichtuniversity.nl/en/publications/81c40662-f66f-4f33-9638-e074a3cb88d3.
    10.3389/fcell.2020.00604
  35. Asim Cengiz Akbulut; Angelina Pavlic; Ploingarm Petsophonsakul; Maurice Halder; Katarzyna Maresz; Rafael Kramann; Leon Schurgers. "Vitamin K2 Needs an RDI Separate from Vitamin K1". Nutrients 12 6 (2020): 1852-1852. https://doi.org/10.3390/nu12061852.
    10.3390/nu12061852
  36. Lu Dai; Björn K. Meijers; Bert Bammens; Henriette de Loor; Leon J. Schurgers; Abdul Rashid Qureshi; Peter Stenvinkel; Pieter Evenepoel. "Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug–Bug Interaction?". Toxins 12 6 (2020): 351-351. https://doi.org/10.3390/toxins12060351.
    10.3390/toxins12060351
  37. Armand Jaminon; Lu Dai; Abdul Rashid Qureshi; Pieter Evenepoel; Jonaz Ripsweden; Magnus Soderberg; Anna Witasp; et al. "Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease". Scientific Reports 10 1 (2020): https://cris.maastrichtuniversity.nl/en/publications/76acec4f-654f-42b3-b632-67e0701dfb88.
    10.1038/s41598-020-63013-8
  38. Elisa d'Alessandro; Christian Becker; Wolfgang Bergmeier; Christoph Bode; Joshua H. Bourne; Helena Brown; Harry R. Buller; et al. "Thrombo-Inflammation in Cardiovascular Disease". Thrombosis and Haemostasis 120 4 (2020): 538-564. https://cris.maastrichtuniversity.nl/en/publications/4443f5b1-76c4-40ea-baf9-0660bd4223d2.
    10.1055/s-0040-1708035
  39. Lu Dai; Leon Schurgers; Paul G. Shiels; Peter Stenvinkel. "Early vascular ageing in chronic kidney disease". Nephrology Dialysis Transplantation 35 (2020): 31-37. https://cris.maastrichtuniversity.nl/en/publications/296e8cf3-8ed5-44a1-a525-006416681add.
    10.1093/ndt/gfaa006
  40. Lu Dai; Oscar Plunde; Abdul Rashid Qureshi; Bengt Lindholm; Torkel B. Brismar; Leon J. Schurgers; Magnus Söderberg; et al. "Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease". Journal of Clinical Medicine 9 2 (2020): 607-607. https://doi.org/10.3390/jcm9020607.
    10.3390/jcm9020607
  41. Nadine Kaesler; Claudia Goettsch; Daniel Weis; Leon Schurgers; Burkhard Hellmann; Juergen Floege; Rafael Kramann. "Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia". Nephrology Dialysis Transplantation 35 1 (2020): 65-73. https://cris.maastrichtuniversity.nl/en/publications/998d447d-da22-4a71-8fa0-978a3da3e430.
    10.1093/ndt/gfy410
  42. Liv M. Vossen; Abraham A. Kroon; Leon J. Schurgers; Peter W. de Leeuw. "Pharmacological and Nutritional Modulation of Vascular Calcification". Nutrients (2019): https://doi.org/10.3390/nu12010100.
    10.3390/nu12010100
  43. Jelle J. Posthuma; Jens J. N. Posma; Rene van Oerle; Peter Leenders; Rick H. van Gorp; Armand M. G. Jaminon; Nigel Mackman; et al. "Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-019-40602-w.
    10.1038/s41598-019-40602-w
  44. Armand Jaminon; Koen Reesink; Abraham Kroon; Leon Schurgers. "The Role of Vascular Smooth Muscle Cells in Arterial Remodeling: Focus on Calcification-Related Processes". International Journal of Molecular Sciences 20 22 (2019): 5694-5694. https://doi.org/10.3390/ijms20225694.
    10.3390/ijms20225694
  45. Maurice Halder; Ploingarm Petsophonsakul; Asim Akbulut; Angelina Pavlic; Frode Bohan; Eric Anderson; Katarzyna Maresz; Rafael Kramann; Leon Schurgers. "Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease". International Journal of Molecular Sciences 20 4 (2019): 896-896. https://doi.org/10.3390/ijms20040896.
    10.3390/ijms20040896
  46. Grzegorz B. Wasilewski; Marc G. Vervloet; Leon Schurgers. "The Bone-Vasculature Axis". Frontiers in cardiovascular medicine 6 (2019): 1-16. https://cris.maastrichtuniversity.nl/en/publications/b4429776-d956-473f-8a19-82051c88dadd.
    10.3389/fcvm.2019.00006
  47. Sofia Dahlberg; Leon Schurgers; Ulf Schött; Thomas Kander. "Vitamin K deficiency in critical ill patients; a prospective observational study". Journal of Critical Care 49 (2019): 105-109. https://doi.org/10.1016/j.jcrc.2018.10.022.
    10.1016/j.jcrc.2018.10.022
  48. Adriana J. van Ballegooijen; Joline W. J. Beulens; Leon Schurgers; Elisa J. de Koning; Paul Lips; Natasja M. van Schoor; Marc Vervloet. "Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults". Nutrients (2019): http://www.mdpi.com/2072-6643/11/2/231.
    10.3390/nu11020231
  49. Ruth Gussenhoven; Luise Klein; Daan Ophelders; Denise H. J. Habets; Bernd Giebel; Boris W. Kramer; Leon Schurgers; Chris P. M. Reutelingsperger; Tim G. A. M. Wolfs. "Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy". Journal of Clinical Medicine (2019): http://www.mdpi.com/2077-0383/8/2/137.
    10.3390/jcm8020137
  50. Zwakenberg, S.R.; De Jong, P.A.; Bartstra, J.W.; Van Asperen, R.; Westerink, J.; De Valk, H.; Slart, R.H.J.A.; et al. "The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: A randomized, double-blind, placebo-controlled trial". American Journal of Clinical Nutrition 110 4 (2019): 883-890. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072746779&partnerID=MN8TOARS.
    10.1093/ajcn/nqz147
  51. Dekker, L.H.; Vinke, P.C.; Riphagen, I.J.; Minovic, I.; Eggersdorfer, M.L.; van den Heuvel, E.G.H.M.; Schurgers, L.J.; et al. "Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population". Frontiers in Nutrition 6 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077368556&partnerID=MN8TOARS.
    10.3389/fnut.2019.00185
  52. Bucerius, J.; Dijkgraaf, I.; Mottaghy, F.M.; Schurgers, L.J.. "Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon". European Journal of Nuclear Medicine and Molecular Imaging 46 1 (2019): 251-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054871866&partnerID=MN8TOARS.
    10.1007/s00259-018-4176-z
  53. Schumacher, S.P.; Schurgers, L.J.; Vervloet, M.G.; Neradova, A.. "Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study". Nephrology 24 2 (2019): 221-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044849834&partnerID=MN8TOARS.
    10.1111/nep.13245
  54. Dudink, E.; Florijn, B.; Weijs, B.; Duijs, J.; Luermans, J.; Peeters, F.; Schurgers, L.; et al. "Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles". MicroRNA (Shariqah, United Arab Emirates) 8 2 (2019): 127-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062602920&partnerID=MN8TOARS.
    10.2174/2211536608666181122125208
  55. Rao, P.S.; Ramanjaneyulu, Y.S.; Prisk, V.R.; Schurgers, L.J.. "A combination of tamarindus indica seeds and curcuma longa rhizome extracts improves knee joint function and alleviates pain in non-arthritic adults following physical activity". International Journal of Medical Sciences 16 6 (2019): 845-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069456433&partnerID=MN8TOARS.
    10.7150/ijms.32505
  56. Petsophonsakul, P.; Furmanik, M.; Forsythe, R.; Dweck, M.; Schurink, G.W.; Natour, E.; Reutelingsperger, C.; et al. "Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation involvement of Vitamin K-dependent processes". Arteriosclerosis, Thrombosis, and Vascular Biology 39 7 (2019): 1351-1368. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068887879&partnerID=MN8TOARS.
    10.1161/ATVBAHA.119.312787
  57. Peeters, M.T.J.; Houben, R.; Postma, A.A.; van Oostenbrugge, R.J.; Schurgers, L.J.; Staals, J.. "Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage". Frontiers in Neurology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077440861&partnerID=MN8TOARS.
    10.3389/fneur.2019.01278
  58. R. Stöhr; N. Deckers; L. Schurgers; N. Marx; C. P. Reutelingsperger. "AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-35995-z.
    10.1038/s41598-018-35995-z
  59. Arnaud Michaux; Benjamin Matagrin; Jean-Valéry Debaux; Leon J. Schurgers; Etienne Benoit; Virginie Lattard. "Missense mutation of VKORC1 leads to medial arterial calcification in rats". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-31788-6.
    10.1038/s41598-018-31788-6
  60. Frederique E C M Peeters; Dudink EAMP; Dorien M Kimenai; Bob Weijs; Sibel Altintas; Luuk Heckman; Casper Mihl; et al. "Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation". TH open : companion journal to thrombosis and haemostasis 2 4 (2018): e391-e398. https://cris.maastrichtuniversity.nl/en/publications/65407018-8a2b-4c54-a2e2-da8066d5d379.
    10.1055/s-0038-1675578
  61. Thijs T. Jansz; Xianwu Cheng; Aegida Neradova; Adriana J. van Ballegooijen; Marianne C. Verhaar; Marc G. Vervloet; Leon J. Schurgers; Brigit C. van Jaarsveld. "The role of kidney transplantation and phosphate binder use in vitamin K status". PLOS ONE (2018): https://doi.org/10.1371/journal.pone.0203157.
    10.1371/journal.pone.0203157
  62. Schurgers, Leon. "Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study". Nutrients (2018): http://www.mdpi.com/2072-6643/10/6/734.
    10.3390/nu10060734
  63. Schurgers, Leon. "A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers". Nutrients (2018): http://www.mdpi.com/2072-6643/10/6/751.
    10.3390/nu10060751
  64. Leon Schurgers; Asim C. Akbulut; Dawid Kaczor; Maurice Halder; Rory Koenen; Rafael Kramann. "Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles". Frontiers in cardiovascular medicine 5 (2018): https://cris.maastrichtuniversity.nl/en/publications/b7d207e1-03a5-44e9-8bb7-d40273f80b16.
    10.3389/fcvm.2018.00036
  65. Schurgers, Leon. "Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design". Nutrients (2018): http://www.mdpi.com/2072-6643/10/4/386.
    10.3390/nu10040386
  66. Willems, B.A.; Furmanik, M.; Caron, M.M.J.; Chatrou, M.L.L.; Kusters, D.H.M.; Welting, T.J.M.; Stock, M.; et al. "Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044291781&partnerID=MN8TOARS.
    10.1038/s41598-018-23353-y
  67. Miyata, K.N.; Nast, C.C.; Dai, T.; Dukkipati, R.; LaPage, J.A.; Troost, J.P.; Schurgers, L.J.; Kretzler, M.; Adler, S.G.. "Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome". Experimental and Molecular Pathology 105 1 (2018): 120-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049725561&partnerID=MN8TOARS.
    10.1016/j.yexmp.2018.07.001
  68. Dahlberg, S.; Ede, J.; Schurgers, L.; Vermeer, C.; Kander, T.; Klarin, B.; Schött, U.. "Desphospho-uncarboxylated matrix-gla protein is increased postoperatively in cardiovascular risk patients". Nutrients 10 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044320355&partnerID=MN8TOARS.
    10.3390/nu10010046
  69. Reutelingsperger, C.; Schurgers, L.. "Coronary Artery Calcification: A Janus-Faced Biomarker?*". JACC: Cardiovascular Imaging 11 9 (2018): 1324-1326. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025647026&partnerID=MN8TOARS.
    10.1016/j.jcmg.2017.04.009
  70. Peeters, F.E.C.M.; Meex, S.J.R.; Dweck, M.R.; Aikawa, E.; Crijns, H.J.G.M.; Schurgers, L.J.; Kietselaer, B.L.J.H.. "Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment". European heart journal 39 28 (2018): 2618-2624. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054962574&partnerID=MN8TOARS.
    10.1093/eurheartj/ehx653
  71. Viegas, C.S.B.; Santos, L.; Macedo, A.L.; Matos, A.A.; Silva, A.P.; Neves, P.L.; Staes, A.; et al. "Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: A role for GRP (Gla-Rich Protein)". Arteriosclerosis, Thrombosis, and Vascular Biology 38 3 (2018): 575-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046012631&partnerID=MN8TOARS.
    10.1161/ATVBAHA.117.310578
  72. E Houben; A Neradova; Leon Schurgers; Marc Vervloet. "The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification". Giornale italiano di nefrologia : organo ufficiale della Societa` italiana di nefrologia 33 6 (2017): 1-10. https://cris.maastrichtuniversity.nl/en/publications/4c1499bd-c7c2-48a9-8b0e-1e9dd07c3202.
  73. Neradova, A.; Schumacher, S.P.; Hubeek, I.; Lux, P.; Schurgers, L.J.; Vervloet, M.G.. "Phosphate binders affect Vitamin K concentration by undesired binding, an in vitro study". BMC Nephrology 18 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018374135&partnerID=MN8TOARS.
    10.1186/s12882-017-0560-3
  74. Vajen, T.; Benedikter, B.J.; Heinzmann, A.C.A.; Vasina, E.M.; Henskens, Y.; Parsons, M.; Maguire, P.B.; et al. "Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype". Journal of Extracellular Vesicles 6 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019480296&partnerID=MN8TOARS.
    10.1080/20013078.2017.1322454
  75. Burgmaier, M.; Reith, S.; Schurgers, L.; Kahles, F.; Marx, N.; Reutelingsperger, C.. "Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition". Diabetes and Vascular Disease Research 14 5 (2017): 415-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029708888&partnerID=MN8TOARS.
    10.1177/1479164117710392
  76. Hendrikx, G.; Hackeng, T.M.; Van Gorp, R.; Bauwens, M.; Schurgers, L.J.; Mottaghy, F.M.; Post, M.J.; Dijkgraaf, I.. "Use of cyclic backbone NGR-based SPECT to increase efficacy of postmyocardial infarction angiogenesis imaging". Contrast Media and Molecular Imaging 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042211665&partnerID=MN8TOARS.
    10.1155/2017/8638549
  77. Brandenburg, V.M.; Reinartz, S.; Kaesler, N.; Krüger, T.; Dirrichs, T.; Kramann, R.; Peeters, F.; et al. "Slower progress of aortic valve calcification with Vitamin K supplementation: Results from a prospective interventional proof-of-concept study". Circulation 135 21 (2017): 2081-2083. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019684050&partnerID=MN8TOARS.
    10.1161/CIRCULATIONAHA.116.027011
  78. Chen, Z.; Qureshi, A.R.; Parini, P.; Hurt-Camejo, E.; Ripsweden, J.; Brismar, T.B.; Barany, P.; et al. "Does statins promote vascular calcification in chronic kidney disease?". European Journal of Clinical Investigation 47 2 (2017): 137-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010807433&partnerID=MN8TOARS.
    10.1111/eci.12718
  79. Kapustin, A.N.; Schoppet, M.; Schurgers, L.J.; Reynolds, J.L.; McNair, R.; Heiss, A.; Jahnen-Dechent, W.; et al. "Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification". Arteriosclerosis, Thrombosis, and Vascular Biology 37 3 (2017): e22-e32. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009960834&partnerID=MN8TOARS.
    10.1161/ATVBAHA.116.308886
  80. Döring, Y.; Noels, H.; Van Der Vorst, E.P.C.; Neideck, C.; Egea, V.; Drechsler, M.; Mandl, M.; et al. "Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: Evidence from mouse and human studies". Circulation 136 4 (2017): 388-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020235110&partnerID=MN8TOARS.
    10.1161/CIRCULATIONAHA.117.027646
  81. Stöhr, R.; Schurgers, L.; Van Gorp, R.; Jaminon, A.; Marx, N.; Reutelingsperger, C.. "Annexin A5 reduces early plaque formation in ApoE -/- mice". PLoS ONE 12 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85038946809&partnerID=MN8TOARS.
    10.1371/journal.pone.0190229
  82. Horn, P.; Erkilet, G.; Veulemans, V.; Kröpil, P.; Schurgers, L.; Zeus, T.; Heiss, C.; Kelm, M.; Westenfeld, R.. "Microparticle-induced coagulation relates to coronary artery atherosclerosis in severe aortic valve stenosis". PLoS ONE 11 3 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962054004&partnerID=MN8TOARS.
    10.1371/journal.pone.0151499
  83. Card, D.J.; Shearer, M.J.; Schurgers, L.J.; Gomez, K.; Harrington, D.J.. "What's in a name? The pharmacy of vitamin K". British Journal of Haematology 174 6 (2016): 989-990. http://www.scopus.com/inward/record.url?eid=2-s2.0-84985910535&partnerID=MN8TOARS.
    10.1111/bjh.13828
  84. Burgmaier, M.; Schurgers, L.; Reutelingsperger, C.. "Response to letter to the editor: Annexin A5 levels or circulating microparticles: What we see depends mainly on what we look for". Journal of Internal Medicine 279 6 (2016): 606-607. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955091090&partnerID=MN8TOARS.
    10.1111/joim.12459
  85. Schlieper, G.; Schurgers, L.; Brandenburg, V.; Reutelingsperger, C.; Floege, J.. "Vascular calcification in chronic kidney disease: An update". Nephrology Dialysis Transplantation 31 1 (2016): 31-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960157825&partnerID=MN8TOARS.
    10.1093/ndt/gfv111
  86. Schurgers, L.J.; Burgmaier, M.; Ueland, T.; Schutters, K.; Aakhus, S.; Hofstra, L.; Gullestad, L.; et al. "Circulating annexin A5 predicts mortality in patients with heart failure". Journal of Internal Medicine 279 1 (2016): 89-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949575592&partnerID=MN8TOARS.
    10.1111/joim.12396
  87. Donners, M.M.P.C.; Bai, L.; Lutgens, S.P.M.; Wijnands, E.; Johnson, J.; Schurgers, L.J.; Liu, C.-L.; et al. "Cathepsin k deficiency prevents the aggravated vascular remodeling response to flow cessation in ApoE-/- Mice". PLoS ONE 11 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992379992&partnerID=MN8TOARS.
    10.1371/journal.pone.0162595
  88. Brandenburg, V.M.; Evenepoel, P.; Floege, J.; Goldsmith, D.; Kramann, R.; Massy, Z.; Mazzaferro, S.; et al. "Lack of evidence does not justify neglect: How can we address unmet medical needs in calciphylaxis?". Nephrology Dialysis Transplantation 31 8 (2016): 1211-1219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982142817&partnerID=MN8TOARS.
    10.1093/ndt/gfw025
  89. Zaragatski, E.; Grommes, J.; Schurgers, L.J.; Langer, S.; Kennes, L.; Tamm, M.; Koeppel, T.A.; et al. "Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: Role of Vitamin K treatment?". Kidney International 89 3 (2016): 601-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944112208&partnerID=MN8TOARS.
    10.1038/ki.2015.298
  90. Houben, E.; Neradova, A.; Schurgers, L.J.; Vervloet, M.. "The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review". Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 33 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85031722902&partnerID=MN8TOARS.
  91. Houben E.; A. Neradova; Leon Schurgers; Marc Vervloet. "L’influenza del fosforo, del calcio e del magnesio sulla proteina Gla di matrice e sul processo di calcificazione vascolare: una review sistematica". Giornale italiano di nefrologia : organo ufficiale della Societa` italiana di nefrologia 33 6 (2016): https://cris.maastrichtuniversity.nl/en/publications/bf3d091d-84ef-4957-a89e-a7a207f6c22f.
  92. Vossen, L.M.; Schurgers, L.J.; van Varik, B.J.; Kietselaer, B.L.J.H.; Vermeer, C.; Meeder, J.G.; Rahel, B.M.; et al. "Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: Rationale and study protocol (VitaK-CAC Trial)". Nutrients 7 11 (2015): 8905-8915. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946061535&partnerID=MN8TOARS.
    10.3390/nu7115443
  93. Kapustin, A.N.; Chatrou, M.L.L.; Drozdov, I.; Zheng, Y.; Davidson, S.M.; Soong, D.; Furmanik, M.; et al. "Vascular smooth muscle cell calcification is mediated by regulated exosome secretion". Circulation Research 116 8 (2015): 1312-1323. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930803061&partnerID=MN8TOARS.
    10.1161/CIRCRESAHA.116.305012
  94. van Niel, G.; Bergam, P.; Di Cicco, A.; Hurbain, I.; Lo Cicero, A.; Dingli, F.; Palmulli, R.; et al. "Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells". Cell Reports 13 1 (2015): 43-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943352447&partnerID=MN8TOARS.
    10.1016/j.celrep.2015.08.057
  95. Van Der Vorst, E.P.C.; Jeurissen, M.; Wolfs, I.M.J.; Keijbeck, A.; Theodorou, K.; Wijnands, E.; Schurgers, L.; et al. "Myeloid a disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis". American Journal of Pathology 185 4 (2015): 1145-1155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925321646&partnerID=MN8TOARS.
    10.1016/j.ajpath.2014.11.028
  96. Kusters, D.H.M.; Chatrou, M.L.; Willems, B.A.G.; De Saint-Hubert, M.; Bauwens, M.; Van Der Vorst, E.; Bena, S.; et al. "Pharmacological treatment with annexin A1 reduces atherosclerotic plaque burden in LDLR-/- mice on Western Type Diet". PLoS ONE 10 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84939190711&partnerID=MN8TOARS.
    10.1371/journal.pone.0130484
  97. Chatrou, M.L.L.; Cleutjens, J.P.; Van Vusse, G.J.D.; Roijers, R.B.; Mutsaers, P.H.A.; Schurgers, L.J.. "Intra-section analysis of human coronary arteries reveals a potential role for micro-calcifications in macrophage recruitment in the early stage of atherosclerosis". PLoS ONE 10 11 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84953455363&partnerID=MN8TOARS.
    10.1371/journal.pone.0142335
  98. Scheiber, D.; Veulemans, V.; Horn, P.; Chatrou, M.L.; Potthoff, S.A.; Kelm, M.; Schurgers, L.J.; Westenfeld, R.. "High-dose menaquinone-7 supplementation reduces cardiovascular calcification in a murine model of extraosseous calcification". Nutrients 7 8 (2015): 6991-7011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940836409&partnerID=MN8TOARS.
    10.3390/nu7085318
  99. Brandenburg, V.M.; Schurgers, L.J.; Kaesler, N.; Püsche, K.; van Gorp, R.H.; Leftheriotis, G.; Reinartz, S.; Koos, R.; Krüger, T.. "Prevention of vasculopathy by vitamin K supplementation: Can we turn fiction into fact?". Atherosclerosis 240 1 (2015): 10-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923928891&partnerID=MN8TOARS.
    10.1016/j.atherosclerosis.2015.02.040
  100. van Gorp, R.H.; Schurgers, L.J.. "New insights into the pros and cons of the clinical use of vitamin K antagonists (VKAs) versus direct oral anticoagulants (DOACs)". Nutrients 7 11 (2015): 9538-9557. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947439921&partnerID=MN8TOARS.
    10.3390/nu7115479
  101. Li, Q.; Brodsky, J.L.; Conlin, L.K.; Pawel, B.; Glatz, A.C.; Gafni, R.I.; Schurgers, L.; et al. "Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: Genotypic overlap with pseudoxanthoma elasticum". Journal of Investigative Dermatology 134 3 (2014): 658-665. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894079801&partnerID=MN8TOARS.
    10.1038/jid.2013.370
  102. Krueger, T.; Schlieper, G.; Schurgers, L.; Cornelis, T.; Cozzolino, M.; Jacobi, J.; Jadoul, M.; et al. "Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): A rationale and study protocol". Nephrology Dialysis Transplantation 29 9 (2014): 1633-1638. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907402723&partnerID=MN8TOARS.
    10.1093/ndt/gft459
  103. Willems, B.A.G.; Vermeer, C.; Reutelingsperger, C.P.M.; Schurgers, L.J.. "The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification". Molecular Nutrition and Food Research 58 8 (2014): 1620-1635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905385001&partnerID=MN8TOARS.
    10.1002/mnfr.201300743
  104. Ungethüm, L.; Chatrou, M.; Kusters, D.; Schurgers, L.; Reutelingsperger, C.P.. "Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake". PLoS ONE 9 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84900451033&partnerID=MN8TOARS.
    10.1371/journal.pone.0096749
  105. Burgmaier, M.; Schutters, K.; Willems, B.; van der Vorst, E.P.C.; Kusters, D.; Chatrou, M.; Norling, L.; et al. "AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE-/- mice". Journal of Cellular and Molecular Medicine 18 10 (2014): 2117-2124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908052246&partnerID=MN8TOARS.
    10.1111/jcmm.12374
  106. Schurgers, L.J.; Spronk, H.M.H.. "Differential cellular effects of old and new oral anticoagulants: Consequences to the genesis and progression of atherosclerosis". Thrombosis and Haemostasis 112 5 (2014): 909-917. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908553711&partnerID=MN8TOARS.
    10.1160/TH14-03-0268
  107. Boraldi, F.; Garcia-Fernandez, M.; Paolinelli-deVincenzi, C.; Annovi, G.; Schurgers, L.; Vermeer, C.; Cianciulli, P.; Ronchetti, I.; Quaglino, D.. "Ectopic calcification in ß-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 12 (2013): 2077-2084. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882802165&partnerID=MN8TOARS.
    10.1016/j.bbadis.2013.07.017
  108. Dalmeijer, G.W.; Van der Schouw, Y.T.; Vermeer, C.; Magdeleyns, E.J.; Schurgers, L.J.; Beulens, J.W.J.. "Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women". Journal of Nutritional Biochemistry 24 4 (2013): 624-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875066884&partnerID=MN8TOARS.
    10.1016/j.jnutbio.2012.02.012
  109. Theuwissen, E.; Teunissen, K.J.; Spronk, H.M.H.; Hamulyák, K.; Ten Cate, H.; Shearer, M.J.; Vermeer, C.; Schurgers, L.J.. "Effect of low-dose supplements of menaquinone-7 (vitamin K2) on the stability of oral anticoagulant treatment: Dose-response relationship in healthy volunteers". Journal of Thrombosis and Haemostasis 11 6 (2013): 1085-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883805659&partnerID=MN8TOARS.
    10.1111/jth.12203
  110. Kramann, R.; Brandenburg, V.M.; Schurgers, L.J.; Ketteler, M.; Westphal, S.; Leisten, I.; Bovi, M.; et al. "Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy". Nephrology Dialysis Transplantation 28 4 (2013): 856-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875993926&partnerID=MN8TOARS.
    10.1093/ndt/gfs466
  111. Li, Q.; Guo, H.; Chou, D.W.; Harrington, D.J.; Schurgers, L.J.; Terry, S.F.; Uitto, J.. "Warfarin accelerates ectopic mineralization in Abcc6-/- mice: Clinical relevance to pseudoxanthoma elasticum". American Journal of Pathology 182 4 (2013): 1139-1150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875151927&partnerID=MN8TOARS.
    10.1016/j.ajpath.2012.12.037
  112. Brandenburg, V.M.; Kramann, R.; Koos, R.; Krüger, T.; Schurgers, L.; Mühlenbruch, G.; Hübner, S.; et al. "Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: A cross-sectional study". BMC Nephrology 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885142378&partnerID=MN8TOARS.
    10.1186/1471-2369-14-219
  113. Krüger, T.; Oelenberg, S.; Kaesler, N.; Schurgers, L.J.; Van De Sandt, A.M.; Boor, P.; Schlieper, G.; et al. "Warfarin induces cardiovascular damage in mice". Arteriosclerosis, Thrombosis, and Vascular Biology 33 11 (2013): 2618-2624. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887045526&partnerID=MN8TOARS.
    10.1161/ATVBAHA.113.302244
  114. Boraldi, F.; Annovi, G.; Vermeer, C.; Schurgers, L.J.; Trenti, T.; Tiozzo, R.; Guerra, D.; Quaglino, D.. "Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls". Journal of Investigative Dermatology 133 4 (2013): 946-954. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875216385&partnerID=MN8TOARS.
    10.1038/jid.2012.460
  115. Schurgers, L.J.. "Vitamin K: Key vitamin in controlling vascular calcification in chronic kidney disease". Kidney International 83 5 (2013): 782-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877062937&partnerID=MN8TOARS.
    10.1038/ki.2013.26
  116. Schutters, K.; Kusters, D.H.M.; Chatrou, M.L.L.; Montero-Melendez, T.; Donners, M.; Deckers, N.M.; Krysko, D.V.; et al. "Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells". Cell Death and Differentiation 20 1 (2013): 49-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870993905&partnerID=MN8TOARS.
    10.1038/cdd.2012.107
  117. Schurgers, L.J.; Uitto, J.; Reutelingsperger, C.P.. "Vitamin K-dependent carboxylation of matrix Gla-protein: A crucial switch to control ectopic mineralization". Trends in Molecular Medicine 19 4 (2013): 217-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875843626&partnerID=MN8TOARS.
    10.1016/j.molmed.2012.12.008
  118. Schurgers, L.J.; Joosen, I.A.; Laufer, E.M.; Chatrou, M.L.L.; Herfs, M.; Winkens, M.H.M.; Westenfeld, R.; et al. "Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype". PLoS ONE 7 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865598969&partnerID=MN8TOARS.
    10.1371/journal.pone.0043229
  119. Brandenburg, V.; Al-Fakhri, N.; Nemeth, K.; Goettsch, C.; Schurgers, L.J.; Vermeer, C.; Hofbauer, L.C.; Schoppet, M.. "Calcification inhibitors in vascular calciphylaxis associated with normal renal function". Thrombosis and Haemostasis 108 6 (2012): 1241-1243. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871423831&partnerID=MN8TOARS.
    10.1160/TH12-07-0484
  120. Theuwissen, E.; Cranenburg, E.C.; Knapen, M.H.; Magdeleyns, E.J.; Teunissen, K.J.; Schurgers, L.J.; Smit, E.; Vermeer, C.. "Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects". British Journal of Nutrition 108 9 (2012): 1652-1657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869492713&partnerID=MN8TOARS.
    10.1017/S0007114511007185
  121. Boxma, P.Y.; van den Berg, E.; Geleijnse, J.M.; Laverman, G.D.; Schurgers, L.J.; Vermeer, C.; Kema, I.P.; et al. "Vitamin K Intake and Plasma Desphospho-Uncarboxylated Matrix Gla-Protein Levels in Kidney Transplant Recipients". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868293692&partnerID=MN8TOARS.
    10.1371/journal.pone.0047991
  122. Chatrou, M.L.L.; Winckers, K.; Hackeng, T.M.; Reutelingsperger, C.P.; Schurgers, L.J.. "Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists". Blood Reviews 26 4 (2012): 155-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861479914&partnerID=MN8TOARS.
    10.1016/j.blre.2012.03.002
  123. Sato, T.; Schurgers, L.J.; Uenishi, K.. "Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women". Nutrition Journal 11 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868634391&partnerID=MN8TOARS.
    10.1186/1475-2891-11-93
  124. Van Varik, B.J.; Rennenberg, R.J.M.W.; Reutelingsperger, C.P.; Kroon, A.A.; De Leeuw, P.W.; Schurgers, L.J.. "Mechanisms of arterial remodeling: Lessons from genetic diseases". Frontiers in Genetics 3 DEC (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876076876&partnerID=MN8TOARS.
    10.3389/fgene.2012.00290
  125. Kusters, D.H.M.; Tegtmeier, J.; Schurgers, L.J.; Reutelingsperger, C.P.M.. "Molecular imaging to identify the vulnerable plaque-from basic research to clinical practice". Molecular Imaging and Biology 14 5 (2012): 523-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870396285&partnerID=MN8TOARS.
    10.1007/s11307-012-0586-7
  126. Westenfeld, R.; Krueger, T.; Schlieper, G.; Cranenburg, E.C.M.; Magdeleyns, E.J.; Heidenreich, S.; Holzmann, S.; et al. "Effect of vitamin K 2 supplementation on functional vitamin K deficiency in hemodialysis patients: A randomized trial". American Journal of Kidney Diseases 59 2 (2012): 186-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855832865&partnerID=MN8TOARS.
    10.1053/j.ajkd.2011.10.041
  127. Cranenburg, E.C.M.; Schurgers, L.J.; Uiterwijk, H.H.; Beulens, J.W.J.; Dalmeijer, G.W.; Westerhuis, R.; Magdeleyns, E.J.; et al. "Vitamin K intake and status are low in hemodialysis patients". Kidney International 82 5 (2012): 605-610. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865227042&partnerID=MN8TOARS.
    10.1038/ki.2012.191
  128. Knapen, M.H.J.; Schurgers, L.J.; Shearer, M.J.; Newman, P.; Theuwissen, E.; Vermeer, C.. "Association of vitamin K status with adiponectin and body composition in healthy subjects: Uncarboxylated osteocalcin is not associated with fat mass and body weight". British Journal of Nutrition 108 6 (2012): 1017-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866139256&partnerID=MN8TOARS.
    10.1017/S000711451100626X
  129. Van De Vijver, P.; Schmitt, M.; Suylen, D.; Scheer, L.; Thomassen, M.C.L.G.D.; Schurgers, L.J.; Griffin, J.H.; Koenen, R.R.; Hackeng, T.M.. "Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S". Journal of the American Chemical Society 134 47 (2012): 19318-19321. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870357551&partnerID=MN8TOARS.
    10.1021/ja306993t
  130. Kaesler, N.; Schettgen, T.; Mutucumarana, V.P.; Brandenburg, V.; Jahnen-Dechent, W.; Schurgers, L.J.; Krüger, T.. "A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity". Analytical Biochemistry 421 2 (2012): 411-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859719877&partnerID=MN8TOARS.
    10.1016/j.ab.2011.11.036
  131. Jiang, Q.; Li, Q.; Grand-Pierre, A.E.; Schurgers, L.J.; Uitto, J.. "Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6-/- mice, a model for pseudoxanthoma elasticum". Cell Cycle 10 4 (2011): 701-707. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951873279&partnerID=MN8TOARS.
    10.4161/cc.10.4.14862
  132. Noordzij, M.; Cranenburg, E.M.; Engelsman, L.F.; Hermans, M.M.; Boeschoten, E.W.; Brandenburg, V.M.; Bos, W.J.W.; et al. "Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients". Nephrology Dialysis Transplantation 26 5 (2011): 1662-1669. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955624020&partnerID=MN8TOARS.
    10.1093/ndt/gfq582
  133. Cranenburg, E.C.M.; Van Spaendonck-Zwarts, K.Y.; Bonafe, L.; Mittaz Crettol, L.; Rödiger, L.A.; Dikkers, F.G.; Van Essen, A.J.; et al. "Circulating matrix ¿-carboxyglutamate protein (MGP) species are refractory to vitamin K treatment in a new case of Keutel syndrome". Journal of Thrombosis and Haemostasis 9 6 (2011): 1225-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958041606&partnerID=MN8TOARS.
    10.1111/j.1538-7836.2011.04263.x
  134. Kapustin, A.N.; Davies, J.D.; Reynolds, J.L.; McNair, R.; Jones, G.T.; Sidibe, A.; Schurgers, L.J.; et al. "Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization". Circulation Research 109 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79959954425&partnerID=MN8TOARS.
    10.1161/CIRCRESAHA.110.238808
  135. Vanakker, O.M.; Leroy, B.P.; Schurgers, L.J.; Vermeer, C.; Coucke, P.J.; de Paepe, A.. "Atypical presentation of pseudoxanthoma elasticum with abdominal cutis laxa: Evidence for a spectrum of ectopic calcification disorders?". American Journal of Medical Genetics, Part A 155 11 (2011): 2855-2859. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054930217&partnerID=MN8TOARS.
    10.1002/ajmg.a.34264
  136. Chatrou, M.L.L.; Reutelingsperger, C.P.; Schurgers, L.J.. "Role of vitamin K-dependent proteins in the arterial vessel wall". Hamostaseologie 31 4 (2011): 251-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-83755206970&partnerID=MN8TOARS.
    10.5482/ha-1157
  137. Weijs, B.; Blaauw, Y.; Rennenberg, R.J.M.W.; Schurgers, L.J.; Timmermans, C.C.M.M.; Pison, L.; Nieuwlaat, R.; et al. "Patients using vitamin K antagonists show increased levels of coronary calcification: An observational study in low-risk atrial fibrillation patients". European Heart Journal 32 20 (2011): 2555-2562. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054735097&partnerID=MN8TOARS.
    10.1093/eurheartj/ehr226
  138. Ueland, T.; Dahl, C.P.; Gullestad, L.; Aakhus, S.; Broch, K.; Skårdal, R.; Vermeer, C.; Aukrust, P.; Schurgers, L.J.. "Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure". Clinical Science 121 3 (2011): 119-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955602383&partnerID=MN8TOARS.
    10.1042/CS20100589
  139. Gorgels, T.G.M.F.; Waarsing, J.H.; Herfs, M.; Versteeg, D.; Schoensiegel, F.; Sato, T.; Schlingemann, R.O.; et al. "Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum". Journal of Molecular Medicine 89 11 (2011): 1125-1135. http://www.scopus.com/inward/record.url?eid=2-s2.0-80755139715&partnerID=MN8TOARS.
    10.1007/s00109-011-0782-y
  140. Roijers, R.B.; Debernardi, N.; Cleutjens, J.P.M.; Schurgers, L.J.; Mutsaers, P.H.A.; Van Der Vusse, G.J.. "Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries". American Journal of Pathology 178 6 (2011): 2879-2887. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959377360&partnerID=MN8TOARS.
    10.1016/j.ajpath.2011.02.004
  141. Schlieper, G.; Westenfeld, R.; Krüger, T.; Cranenburg, E.C.; Magdeleyns, E.J.; Brandenburg, V.M.; Djuric, Z.; et al. "Circulating nonphosphorylated carboxylated matrix Gla protein predicts survival in ESRD". Journal of the American Society of Nephrology 22 2 (2011): 387-395. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551662074&partnerID=MN8TOARS.
    10.1681/ASN.2010040339
  142. Vanakker, O.M.; Martin, L.; Schurgers, L.J.; Quaglino, D.; Costrop, L.; Vermeer, C.; Pasquali-Ronchetti, I.; Coucke, P.J.; De Paepe, A.. "Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome". Laboratory Investigation 90 6 (2010): 895-905. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954588638&partnerID=MN8TOARS.
    10.1038/labinvest.2010.68
  143. Ueland, T.; Fougner, S.L.; Godang, K.; Lekva, T.; Schurgers, L.J.; Scholz, H.; Halvorsen, B.; et al. "Associations between body composition, circulating interleukin-1 receptor antagonist, osteocalcin, and insulin metabolism in active acromegaly". Journal of Clinical Endocrinology and Metabolism 95 1 (2010): 361-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149151814&partnerID=MN8TOARS.
    10.1210/jc.2009-0422
  144. Ueland, T.; Gullestad, L.; Dahl, C.P.; Aukrust, P.; Aakhus, S.; Solberg, O.G.; Vermeer, C.; Schurgers, L.J.. "Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis". Journal of Internal Medicine 268 5 (2010): 483-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958544238&partnerID=MN8TOARS.
    10.1111/j.1365-2796.2010.02264.x
  145. Van Hasselt, P.M.; De Vries, W.; De Vries, E.; Kok, K.; Cranenburg, E.C.M.; De Koning, T.J.; Schurgers, L.J.; Verkade, H.J.; Houwen, R.H.J.. "Hydrolysed formula is a risk factor for vitamin K deficiency in infants with unrecognised cholestasis". Journal of Pediatric Gastroenterology and Nutrition 51 6 (2010): 773-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650513818&partnerID=MN8TOARS.
    10.1097/MPG.0b013e3181efb0b3
  146. Schurgers, L.J.; Barreto, D.V.; Barreto, F.C.; Liabeuf, S.; Renard, C.; Magdeleyns, E.J.; Vermeer, C.; Choukroun, G.; Massy, Z.A.. "The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: A preliminary report". Clinical Journal of the American Society of Nephrology 5 4 (2010): 568-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950933412&partnerID=MN8TOARS.
    10.2215/CJN.07081009
  147. Parker, B.D.; Schurgers, L.J.; Vermeer, C.; Schiller, N.B.; Whooley, M.A.; Ix, J.H.. "The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study". Atherosclerosis 210 1 (2010): 320-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952428768&partnerID=MN8TOARS.
    10.1016/j.atherosclerosis.2009.11.023
  148. Shroff, R.C.; McNair, R.; Skepper, J.N.; Figg, N.; Schurgers, L.J.; Deanfield, J.; Rees, L.; Shanahan, C.M.. "Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification". Journal of the American Society of Nephrology 21 1 (2010): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149140991&partnerID=MN8TOARS.
    10.1681/ASN.2009060640
  149. Rennenberg, R.J.M.W.; Van Varik, B.J.; Schurgers, L.J.; Hamulyak, K.; Ten Cate, H.; Leiner, T.; Vermeer, C.; De Leeuw, P.W.; Kroon, A.A.. "Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans". Blood 115 24 (2010): 5121-5123. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954677816&partnerID=MN8TOARS.
    10.1182/blood-2010-01-264598
  150. Cranenburg, E.C.M.; Koos, R.; Schurgers, L.J.; Magdeleyns, E.J.; Schoonbrood, T.H.M.; Landewé, R.B.; Brandenburg, V.M.; Bekers, O.; Vermeer, C.. "Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species". Thrombosis and Haemostasis 104 4 (2010): 811-822. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958168617&partnerID=MN8TOARS.
    10.1160/TH09-11-0786
  151. Parker, B.D.; Schurgers, L.J.; Brandenburg, V.M.; Christenson, R.H.; Vermeer, C.; Ketteler, M.; Shlipak, M.G.; Whooley, M.A.; Ix, J.H.. "The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: The heart and soul study". Annals of Internal Medicine 152 10 (2010): 640-648. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952996999&partnerID=MN8TOARS.
    10.7326/0003-4819-152-10-201005180-00004
  152. Le Boulanger, G.; Labrèze, C.; Croué, A.; Schurgers, L.J.; Chassaing, N.; Wittkampf, T.; Rutsch, F.; Martin, L.. "An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy". American Journal of Medical Genetics, Part A 152 1 (2010): 118-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149190148&partnerID=MN8TOARS.
    10.1002/ajmg.a.33162
  153. Wallin, R.; Schurgers, L.J.; Loeser, R.F.. "Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: A fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes". Osteoarthritis and Cartilage 18 8 (2010): 1096-1103. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954656592&partnerID=MN8TOARS.
    10.1016/j.joca.2010.05.013
  154. Rennenberg, R.J.M.W.; De Leeuw, P.W.; Kessels, A.G.H.; Schurgers, L.J.; Vermeer, C.; Van Engelshoven, J.M.A.; Kemerink, G.J.; Kroon, A.A.. "Calcium scores and matrix Gla protein levels: Association with vitamin K status". European Journal of Clinical Investigation 40 4 (2010): 344-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949725834&partnerID=MN8TOARS.
    10.1111/j.1365-2362.2010.02275.x
  155. Schlieper, G.; Grotemeyer, D.; Aretz, A.; Schurgers, L.J.; Krüger, T.; Rehbein, H.; Weirich, T.E.; et al. "Analysis of Calcifications in Patients with Coral Reef Aorta". Annals of Vascular Surgery 24 3 (2010): 408-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649183741&partnerID=MN8TOARS.
    10.1016/j.avsg.2009.11.006
  156. Hristova, M.; Van Beek, C.; Schurgers, L.J.; Lanske, B.; Danziger, J.. "Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation". American Journal of Kidney Diseases 56 6 (2010): 1158-1162. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649450075&partnerID=MN8TOARS.
    10.1053/j.ajkd.2010.06.017
  157. Rennenberg, R.J.M.W.; Schurgers, L.J.; Kroon, A.A.; Stehouwer, C.D.A.. "Arterial calcifications". Journal of Cellular and Molecular Medicine 14 9 (2010): 2203-2210. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649386955&partnerID=MN8TOARS.
    10.1111/j.1582-4934.2010.01139.x
  158. Cosemans, J.M.E.M.; Van Kruchten, R.; Olieslagers, S.; Schurgers, L.J.; Verheyen, F.K.; Munnix, I.C.A.; Waltenberger, J.; et al. "Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization". Journal of Thrombosis and Haemostasis 8 8 (2010): 1797-1808. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958559483&partnerID=MN8TOARS.
    10.1111/j.1538-7836.2010.03935.x
  159. Westenfeld, R.; Schäfer, C.; Krüger, T.; Haarmann, C.; Schurgers, L.J.; Reutelingsperger, C.; Ivanovski, O.; et al. "Fetuin-A protects against atherosclerotic calcification in CKD". Journal of the American Society of Nephrology 20 6 (2009): 1264-1274. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449102482&partnerID=MN8TOARS.
    10.1681/ASN.2008060572
  160. Cranenburg, E.C.M.; Brandenburg, V.M.; Vermeer, C.; Stenger, M.; Mühlenbruch, G.; Mahnken, A.H.; Gladziwa, U.; Ketteler, M.; Schurgers, L.J.. "Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients". Thrombosis and Haemostasis 101 2 (2009): 359-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-62449309045&partnerID=MN8TOARS.
    10.1160/TH08-04-024l
  161. Koos, R.; Krueger, T.; Westenfeld, R.; Kühl, H.P.; Brandenburg, V.; Mahnken, A.H.; Stanzel, S.; et al. "Relation of circulating matrix Gla-protein and anticoagulation status in patients with aortic valve calcification". Thrombosis and Haemostasis 101 4 (2009): 706-713. http://www.scopus.com/inward/record.url?eid=2-s2.0-64849110662&partnerID=MN8TOARS.
    10.1160/TH08-09-0611
  162. Krüger, T.; Westenfeld, R.; Schurgers, L.J.; Brandenburg, V.M.. "Coagulation meets calcification: The vitamin K system". International Journal of Artificial Organs 32 2 (2009): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649311819&partnerID=MN8TOARS.
    10.1177/039139880903200202
  163. Li, Q.; Grange, D.K.; Armstrong, N.L.; Whelan, A.J.; Hurley, M.Y.; Rishavy, M.A.; Hallgren, K.W.; et al. "Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes". Journal of Investigative Dermatology 129 3 (2009): 553-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-59949086567&partnerID=MN8TOARS.
    10.1038/jid.2008.271
  164. Van Summeren, M.J.H.; Braam, L.A.J.L.M.; Lilien, M.R.; Schurgers, L.J.; Kuis, W.; Vermeer, C.. "The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children". British Journal of Nutrition 102 8 (2009): 1171-1178. http://www.scopus.com/inward/record.url?eid=2-s2.0-73749086347&partnerID=MN8TOARS.
    10.1017/S0007114509382100
  165. Mertsch, S.; Schurgers, L.J.; Weber, K.; Paulus, W.; Senner, V.. "Matrix gla protein (MGP): An overexpressed and migration-promoting mesenchymal component in glioblastoma". BMC Cancer 9 (2009): 302-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349873207&partnerID=MN8TOARS.
    10.1186/1471-2407-9-302
  166. Card, D.J.; Shearer, M.J.; Schurgers, L.J.; Harrington, D.J.. "The external quality assurance of phylloquinone (vitamin K1) analysis in human serum". Biomedical Chromatography 23 12 (2009): 1276-1282. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649092932&partnerID=MN8TOARS.
    10.1002/bmc.1250
  167. Rennenberg, R.J.M.W.; Schurgers, L.J.; Vermeer, C.. "Vitamin K in postmenopausal osteopenia,Vitamine K bij postmenopauzale osteopenie". Nederlands Tijdschrift voor Geneeskunde 153 25 (2009): 1204-1205. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957656165&partnerID=MN8TOARS.
  168. Brandenburg, V.; Schurgers, L.J.; Krüger, T.; Westenfeld, R.. "Vitamin K: Its role in bone and vascular health,Rolle des vitamin K bei der knochen- und gefäßgesundheit". Nieren- und Hochdruckkrankheiten 38 8 (2009): 372-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949102957&partnerID=MN8TOARS.
  169. Rennenberg, R.J.M.W.; Kessels, A.G.H.; Schurgers, L.J.; Van Engelshoven, J.M.A.; De Leeuw, P.W.; Kroon, A.A.. "Vascular calcifications as a marker of increased cardiovascular risk: A meta-analysis". Vascular Health and Risk Management 5 (2009): 185-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449105670&partnerID=MN8TOARS.
  170. Parker, B.D.; Ix, J.H.; Cranenburg, E.C.M.; Vermeer, C.; Whooley, M.A.; Schurgers, L.J.. "Association of kidney function and uncarboxylated matrix Gla protein: Data from the Heart and Soul Study". Nephrology Dialysis Transplantation 24 7 (2009): 2095-2101. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651089927&partnerID=MN8TOARS.
    10.1093/ndt/gfp024
  171. Schlieper, G.; Brandenburg, V.; Djuric, Z.; Damjanovic, T.; Markovic, N.; Schurgers, L.; Krüger, T.; et al. "Risk factors for cardiovascular calcifications in non-diabetic Caucasian haemodialysis patients". Kidney and Blood Pressure Research 32 3 (2009): 161-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-66049132128&partnerID=MN8TOARS.
    10.1159/000221064
  172. Krueger, T.; Westenfeld, R.; Ketteler, M.; Schurgers, L.J.; Floege, J.. "Vitamin K deficiency in CKD patients: A modifiable risk factor for vascular calcification?". Kidney International 76 1 (2009): 18-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449146899&partnerID=MN8TOARS.
    10.1038/ki.2009.126
  173. Li, Q.; Schurgers, L.J.; Smith, A.C.M.; Tsokos, M.; Uitto, J.; Cowen, E.W.. "Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: Compound heterozygosity for mutations in the GGCX gene". American Journal of Pathology 174 2 (2009): 534-540. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649091261&partnerID=MN8TOARS.
    10.2353/ajpath.2009.080865
  174. Shroff, R.C.; Shah, V.; Hiorns, M.P.; Schoppet, M.; Hofbauer, L.C.; Hawa, G.; Schurgers, L.J.; et al. "The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis". Nephrology Dialysis Transplantation 23 10 (2008): 3263-3271. http://www.scopus.com/inward/record.url?eid=2-s2.0-52449095331&partnerID=MN8TOARS.
    10.1093/ndt/gfn226
  175. Schurgers, L.J.; Cranenburg, E.C.M.; Vermeer, C.. "Matrix Gla-protein: The calcification inhibitor in need of vitamin K". Thrombosis and Haemostasis 100 4 (2008): 593-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949147219&partnerID=MN8TOARS.
    10.1160/TH08-02-0087
  176. van Summeren, M.J.H.; Hameleers, J.M.; Schurgers, L.J.; Hoeks, A.P.G.; Uiterwaal, C.S.P.M.; Krüger, T.; Vermeer, C.; Kuis, W.; Lilien, M.R.. "Circulating calcification inhibitors and vascular properties in children after renal transplantation". Pediatric Nephrology 23 6 (2008): 985-993. http://www.scopus.com/inward/record.url?eid=2-s2.0-42649138549&partnerID=MN8TOARS.
    10.1007/s00467-007-0743-4
  177. Golledge, J.; Jayalath, R.; Oliver, L.; Parr, A.; Schurgers, L.; Clancy, P.. "Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification". Atherosclerosis 197 1 (2008): 428-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449130169&partnerID=MN8TOARS.
    10.1016/j.atherosclerosis.2007.06.027
  178. Wallin, R.; Schurgers, L.; Wajih, N.. "Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification". Thrombosis Research 122 3 (2008): 411-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849129853&partnerID=MN8TOARS.
    10.1016/j.thromres.2007.12.005
  179. Hermans, M.M.H.; Vermeer, C.; Kooman, J.P.; Brandenburg, V.; Ketteler, M.; Gladziwa, U.; Rensma, P.L.; Leunissen, K.M.L.; Schurgers, L.J.. "Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation index". Blood Purification 25 5-6 (2008): 395-401. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849164395&partnerID=MN8TOARS.
    10.1159/000108629
  180. van Summeren, M.J.H.; Spliet, W.G.M.; van Royen-Kerkhof, A.; Vermeer, C.; Lilien, M.; Kuis, W.; Schurgers, L.J.. "Calcinosis in juvenile dermatomyositis: A possible role for the vitamin K-dependent protein matrix Gla protein". Rheumatology 47 3 (2008): 267-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449098773&partnerID=MN8TOARS.
    10.1093/rheumatology/kem360
  181. Shroff, R.C.; McNair, R.; Figg, N.; Skepper, J.N.; Schurgers, L.; Gupta, A.; Hiorns, M.; et al. "Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis". Circulation 118 17 (2008): 1748-1757. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449101447&partnerID=MN8TOARS.
    10.1161/CIRCULATIONAHA.108.783738
  182. Schlieper, G.; Krüger, T.; Djuric, Z.; Damjanovic, T.; Markovic, N.; Schurgers, L.J.; Brandenburg, V.M.; et al. "Vascular access calcification predicts mortality in hemodialysis patients". Kidney International 74 12 (2008): 1582-1587. http://www.scopus.com/inward/record.url?eid=2-s2.0-57049160362&partnerID=MN8TOARS.
    10.1038/ki.2008.458
  183. Cranenburg, E.C.M.; Vermeer, C.; Koos, R.; Boumans, M.-L.; Hackeng, T.M.; Bouwman, F.G.; Kwaijtaal, M.; et al. "The circulating inactive form of matrix Gla protein (ucMGP) as a biomarker for cardiovascular calcification". Journal of Vascular Research 45 5 (2008): 427-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-50349101161&partnerID=MN8TOARS.
    10.1159/000124863
  184. Vanschoonbeek, K.; Wouters, K.; Van Der Meijden, P.E.J.; Van Gorp, P.J.; Feijge, M.A.H.; Herfs, M.; Schurgers, L.J.; et al. "Anticoagulant effect of dietary fish oil in hyperlipidemia. A study of hepatic gene expression in APOE2 knock-in mice". Arteriosclerosis, Thrombosis, and Vascular Biology 28 11 (2008): 2023-2029. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449109528&partnerID=MN8TOARS.
    10.1161/ATVBAHA.107.156992
  185. Rennenebrg, R.J.M.W.; Schurgers, L.J.; Vermeer, C.; Scholte, J.B.J.; Houben, A.J.H.M.; de Leeuw, P.W.; Kroon, A.A.. "Renal handling of matrix gla-protein in humans with moderate to severe hypertension". Hypertension Research 31 9 (2008): 1745-1751. http://www.scopus.com/inward/record.url?eid=2-s2.0-55449104039&partnerID=MN8TOARS.
  186. van Summeren, M.J.H.; Vermeer, C.; Engelbert, R.H.H.; Schurgers, L.J.; Takken, T.; Fischer, K.; Kuis, W.. "Extremes in vitamin K status of bone are related to bone ultrasound properties in children with juvenile idiopathic arthritis". Clinical and Experimental Rheumatology 26 3 (2008): 484-491. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949117141&partnerID=MN8TOARS.
  187. van Summeren, M.J.H.; van Coeverden, S.C.C.M.; Schurgers, L.J.; Braam, L.A.J.L.M.; Noirt, F.; Uiterwaal, C.S.P.M.; Kuis, W.; Vermeer, C.. "Vitamin K status is associated with childhood bone mineral content". British Journal of Nutrition 100 4 (2008): 852-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-51749087717&partnerID=MN8TOARS.
    10.1017/S0007114508921760
  188. Schurgers, L.J.; Spronk, H.M.H.; Soute, B.A.M.; Schiffers, P.M.; DeMey, J.G.R.; Vermeer, C.. "Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats". Blood 109 7 (2007): 2823-2831. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947578745&partnerID=MN8TOARS.
    10.1182/blood-2006-07-035345
  189. Cario-Toumaniantz, C.; Boularan, C.; Schurgers, L.J.; Heymann, M.-F.; Le Cunff, M.; Léger, J.; Loirand, G.; Pacaud, P.. "Identification of differentially expressed genes in human varicose veins: Involvement of matrix Gla protein in extracellular matrix remodeling". Journal of Vascular Research 44 6 (2007): 444-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648995843&partnerID=MN8TOARS.
    10.1159/000106189
  190. Göritz, C.; Thiebaut, R.; Tessier, L.-H.; Nieweg, K.; Moehle, C.; Buard, I.; Dupont, J.-L.; et al. "Glia-induced neuronal differentiation by transcriptional regulation". GLIA 55 11 (2007): 1108-1122. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547647487&partnerID=MN8TOARS.
    10.1002/glia.20531
  191. Knapen, M.H.J.; Schurgers, L.J.; Vermeer, C.. "Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women". Osteoporosis International 18 7 (2007): 963-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250003777&partnerID=MN8TOARS.
    10.1007/s00198-007-0337-9
  192. Cranenburg, E.C.M.; Schurgers, L.J.; Vermeer, C.. "Vitamin K: The coagulation vitamin that became omnipotent". Thrombosis and Haemostasis 98 1 (2007): 120-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447521886&partnerID=MN8TOARS.
    10.1160/TH07-04-0266
  193. Schurgers, L.J.; Spronk, H.M.H.; Skepper, J.N.; Hackeng, T.M.; Shanahan, C.M.; Vermeer, C.; Weissberg, P.L.; Proudfoot, D.. "Post-translational modifications regulate matrix Gla protein function: Importance for inhibition of vascular smooth muscle cell calcification". Journal of Thrombosis and Haemostasis 5 12 (2007): 2503-2511. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348941029&partnerID=MN8TOARS.
    10.1111/j.1538-7836.2007.02758.x
  194. Gheduzzi, D.; Boraldi, F.; Annovi, G.; DeVincenzi, C.P.; Schurgers, L.J.; Vermeer, C.; Quaglino, D.; Pasquali Ronchetti, I.. "Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients". Laboratory Investigation 87 10 (2007): 998-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548779758&partnerID=MN8TOARS.
    10.1038/labinvest.3700667
  195. Van Langendonckt, A.; Punyadeera, C.; Kamps, R.; Dunselman, G.; Klein-Hitpass, L.; Schurgers, L.J.; Squifflet, J.; Donnez, J.; Groothuis, P.. "Identification of novel antigens in blood vessels in rectovaginal endometriosis". Molecular Human Reproduction 13 12 (2007): 875-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549033840&partnerID=MN8TOARS.
    10.1093/molehr/gam073
  196. Schurgers, L.J.; Teunissen, K.J.F.; Hamulyák, K.; Knapen, M.H.J.; Vik, H.; Vermeer, C.. "Vitamin K-containing dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7". Blood 109 8 (2007): 3279-3283. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147137917&partnerID=MN8TOARS.
    10.1182/blood-2006-08-040709
  197. Li, Q.; Jiang, Q.; Schurgers, L.J.; Uitto, J.. "Pseudoxanthoma elasticum: Reduced ¿-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-)". Biochemical and Biophysical Research Communications 364 2 (2007): 208-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448993299&partnerID=MN8TOARS.
    10.1016/j.bbrc.2007.09.122
  198. Willems, H.P.J.; Den Heijer, M.; Gerrits, W.B.J.; Schurgers, L.J.; Havekes, M.; Blom, H.J.; Bos, G.M.J.. "Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration". European Journal of Internal Medicine 17 2 (2006): 120-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-33144465353&partnerID=MN8TOARS.
    10.1016/j.ejim.2005.10.009
  199. Vermeer, C.; Braam, L.; Knapen, M.; Schurgers, L.. "Vitamin K supplements: Unknown effects for bones and the cardiovascular system,Supplémentation en vitamine K: Des effets méconnus pour l'os et le système cardiovasculaire". Phytotherapie 4 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33646012961&partnerID=MN8TOARS.
    10.1007/s10298-006-0135-0
  200. Janzen, J.; Schurgers, L.J.; Vermeer, C.; Joris, F.; Musy, J.-P.; Schmidli, J.. "Aneurysm with mediacalcifications in the aortic arch,Mediakalzifikationen in einem aneurysma des arcus aortae". Perfusion 19 7-8 (2006): 237-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750099140&partnerID=MN8TOARS.
  201. Thijssen, H.H.W.; Vervoot, L.M.T.; Schurgers, L.J.; Shearer, M.J.. "Menadione is a metabolite of oral vitamin K". British Journal of Nutrition 95 2 (2006): 260-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644921501&partnerID=MN8TOARS.
    10.1079/BJN20051630
  202. Schurgers, L.J.; Teunissen, K.J.F.; Knapen, M.H.J.; Geusens, P.; Van Der Heijde, D.; Kwaijtaal, M.; Van Diest, R.; Ketteler, M.; Vermeer, C.. "Characteristics and performance of an immunosorbent assay for human matrix Gla-protein". Clinica Chimica Acta 351 1-2 (2005): 131-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-9444298992&partnerID=MN8TOARS.
    10.1016/j.cccn.2004.08.003
  203. Demir, A.Y.; Groothuis, P.G.; Dunselman, G.A.J.; Schurgers, L.; Evers, J.L.H.; De Goeij, A.F.P.M.. "Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells". Cell and Tissue Research 322 2 (2005): 299-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944476012&partnerID=MN8TOARS.
    10.1007/s00441-005-0002-6
  204. Schurgers, L.J.; Teunissen, K.J.F.; Knapen, M.H.J.; Kwaijtaal, M.; Van Diest, R.; Appels, A.; Reutelingsperger, C.P.; Cleutjens, J.P.M.; Vermeer, C.. "Novel conformation-specific antibodies against matrix ¿- carboxyglutamic acid (Gla) protein: Undercarboitylated matrix Gla protein as marker for vascular calcification". Arteriosclerosis, Thrombosis, and Vascular Biology 25 8 (2005): 1629-1633. http://www.scopus.com/inward/record.url?eid=2-s2.0-23244458678&partnerID=MN8TOARS.
    10.1161/01.ATV.0000173313.46222.43
  205. Schurgers, L.J.; Shearer, M.J.; Hamulyák, K.; Stöcklin, E.; Vermeer, C.. "Effect of vitamin K intake on the stability of oral anticoagulant treatment: Dose-response relationships in healthy subjects". Blood 104 9 (2004): 2682-2689. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244258903&partnerID=MN8TOARS.
    10.1182/blood-2004-04-1525
  206. Schurgers, L.J.; Aebert, H.; Vermeer, C.; Bültmann, B.; Janzen, J.. "Oral anticoagulant treatment: Friend or foe in cardiovascular disease?". Blood 104 10 (2004): 3231-3232. http://www.scopus.com/inward/record.url?eid=2-s2.0-8644252020&partnerID=MN8TOARS.
    10.1182/blood-2004-04-1277
  207. Ryan, B.M.; Russel, M.G.V.M.; Schurgers, L.; Wichers, M.; Sijbrandij, J.; Stockbrugger, R.W.; Schoon, E.. "Effect of antitumour necrosis factor-a therapy on bone turnover in patients with active Crohn's disease: A prospective study". Alimentary Pharmacology and Therapeutics 20 8 (2004): 851-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-7044224181&partnerID=MN8TOARS.
    10.1111/j.1365-2036.2004.02097.x
  208. Kobayashi, N.; Kitazawa, R.; Maeda, S.; Schurgers, L.J.; Kitazawa, S.. "T-138C polymorphism of matrix Gla protein promoter alters its expression but is not directly associated with atherosclerotic vascular calcification". Kobe Journal of Medical Sciences 50 3-4 (2004): 69-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-22444441867&partnerID=MN8TOARS.
  209. Geleijnse, J.M.; Vermeer, C.; Grobbee, D.E.; Schurgers, L.J.; Knapen, M.H.J.; Van Der Meer, I.M.; Hofman, A.; Witteman, J.C.M.. "Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study". Journal of Nutrition 134 11 (2004): 3100-3105. http://www.scopus.com/inward/record.url?eid=2-s2.0-7944233489&partnerID=MN8TOARS.
  210. Reynolds, J.L.; Joannides, A.J.; Skepper, J.N.; Mcnair, R.; Schurgers, L.J.; Proudfoot, D.; Jahnen-Dechent, W.; Weissberg, P.L.; Shanahan, C.M.. "Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD". Journal of the American Society of Nephrology 15 11 (2004): 2857-2867. http://www.scopus.com/inward/record.url?eid=2-s2.0-14544283020&partnerID=MN8TOARS.
    10.1097/01.ASN.0000141960.01035.28
  211. Spronk, H.M.H.; Soute, B.A.M.; Schurgers, L.J.; Thijssen, H.H.W.; De Mey, J.G.R.; Vermeer, C.. "Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats". Journal of Vascular Research 40 6 (2003): 531-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-0442293394&partnerID=MN8TOARS.
    10.1159/000075344
  212. Ketteler, M.; Wanner, C.; Metzger, T.; Bongartz, P.; Westenfeld, R.; Gladziwa, U.; Schurgers, L.J.; et al. "Deficiencies of calcium-regulatory proteins in dialysis patients: A novel concept of cardiovascular calcification in uremia". Kidney International, Supplement 63 84 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-1842513889&partnerID=MN8TOARS.
  213. Vermeer, C.; Braam, L.; Knapen, M.; Schurgers, L.. "Vitamin K supplementation: A simple way to improve bone and vascular health". Agro Food Industry Hi-Tech 14 6 (2003): 17-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242288031&partnerID=MN8TOARS.
  214. Vermeer, C.; Braam, L.; Schurgers, L.; Brouns, F.. "Increased vitamin K intake by functional foods or food supplements: A new lead to improve cardiovascular and bone health". Agro Food Industry Hi-Tech 13 5 (2002): 11-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036762726&partnerID=MN8TOARS.
  215. Schurgers, L.J.; Shearer, M.J.; Soute, B.A.M.; Elmadfa, I.; Harvey, J.; Wagner, K.-H.; Tomasch, R.; Vermeer, C.. "Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men". Journal of Lipid Research 43 6 (2002): 878-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035988341&partnerID=MN8TOARS.
  216. Celie, P.H.N.; Van Stempvoort, G.; Fribourg, C.; Schurgers, L.J.; Lenting, P.J.; Mertens, K.. "The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain". Journal of Biological Chemistry 277 23 (2002): 20214-20220. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037036401&partnerID=MN8TOARS.
    10.1074/jbc.M108446200
  217. Schurgers, L.J.; Vermeer, C.. "Differential lipoprotein transport pathways of K-vitamins in healthy subjects". Biochimica et Biophysica Acta - General Subjects 1570 1 (2002): 27-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037084981&partnerID=MN8TOARS.
    10.1016/S0304-4165(02)00147-2
  218. Spronk, H.M.H.; Soute, B.A.M.; Schurgers, L.J.; Cleutjens, J.P.M.; Thijssen, H.H.W.; De Mey, J.G.R.; Vermeer, C.. "Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall". Biochemical and Biophysical Research Communications 289 2 (2001): 485-490. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035976773&partnerID=MN8TOARS.
    10.1006/bbrc.2001.5996
  219. Schoon, E.J.; Müller, M.C.A.; Vermeer, C.; Schurgers, L.J.; Brummer, R.-J.M.; Stockbrügger, R.W.. "Low serum and bone vitamin K status in patients with longstanding Crohn's disease: Another pathogenetic factor of osteoporosis in Crohn's disease?". Gut 48 4 (2001): 473-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035080001&partnerID=MN8TOARS.
    10.1136/gut.48.4.473
  220. Schurgers, L.J.; Dissel, P.E.P.; Spronk, H.M.H.; Soute, B.A.M.; Dhore, C.R.; Cleutjens, J.P.M.; Vermeer, C.. "Role of vitamin K and vitamin K-dependent proteins in vascular calcification". Zeitschrift fur Kardiologie 90 (2001): 57-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035075742&partnerID=MN8TOARS.
  221. Schurgers, L.J.; Vermeer, C.. "Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport". Journal of Lipid Research 42 7 (2001): 1120-1124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034953223&partnerID=MN8TOARS.
  222. Schoon, E.J.; Geerling, B.G.; Van Dooren, I.M.A.; Schurgers, L.J.; Vermeer, C.; Brummer, R.-J.M.; Stockbrügger, R.W.. "Abnormal bone turnover in long-standing Crohn's disease in remission". Alimentary Pharmacology and Therapeutics 15 6 (2001): 783-792. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034990684&partnerID=MN8TOARS.
    10.1046/j.1365-2036.2001.00997.x
  223. Vermeer, C.; Schurgers, L.J.. "A comprehensive review of vitamin K and vitamin K antagonists". Hematology/Oncology Clinics of North America 14 2 (2000): 339-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034011505&partnerID=MN8TOARS.
    10.1016/S0889-8588(05)70137-4
  224. Oldenburg, J.; Von Brederlow, B.; Fregin, A.; Rost, S.; Wolz, W.; Eberl, W.; Eber, S.; et al. "Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex". Thrombosis and Haemostasis 84 6 (2000): 937-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034530536&partnerID=MN8TOARS.
  225. Schurgers, L.J.; Vermeer, C.. "Determination of phylloquinone and menaquinones in food: Effect of food matrix on circulating vitamin K concentrations". Haemostasis 30 6 (2000): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034445265&partnerID=MN8TOARS.
  226. Koivu-Tikkanen, T.J.; Schurgers, L.J.; Thijssen, H.H.W.; Vermeer, C.. "Intestinal, hepatic, and circulating vitamin K levels at low and high intakes of vitamin K in rats". British Journal of Nutrition 83 2 (2000): 185-190. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033960722&partnerID=MN8TOARS.
  227. Indyk, H.E.; Woollard, D.C.; Barber, M.; Berge, C.; Booth, S.; Burn, M.; Cecco, A.; et al. "Determination of Vitamin K in Milk and Infant Formulas by Liquid Chromatography: Collaborative Study". Journal of AOAC International 83 1 (2000): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033630972&partnerID=MN8TOARS.
  228. Schurgers, L.J.; Geleijnse, J.M.; Grobbee, D.E.; Pols, H.A.P.; Hofman, A.; Witteman, J.C.M.; Vermeer, C.. "Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in the Netherlands". Journal of Nutritional and Environmental Medicine 9 2 (1999): 115-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033063620&partnerID=MN8TOARS.
    10.1080/13590849961717
  229. Vermeer, C.; Knapen, M.H.J.; Schurgers, L.J.. "Vitamin K and metabolic bone disease". Journal of Clinical Pathology 51 6 (1998): 424-426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031809227&partnerID=MN8TOARS.
    10.1136/jcp.51.6.424
  230. Schoon, E.J.; Geerling, B.; Schurgers, L.; Vermeer, C.; Russel, M.G.; Stockbrügger, R.W.; Brum, R.-J.. "Suppressed bone formation but normal bone resorption in long-standing quiescent crohn’s disease". European Journal of Gastroenterology and Hepatology 10 12 (1998): A16-A16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026152263&partnerID=MN8TOARS.
    10.1097/00042737-199812000-00070
Livro
  1. Leon Schurgers. Vasculaire verkalking. Maastricht University. 2018.
    10.26481/spe.20181012ls
  2. Shearer, M.J.; Gorska, R.; Harrington, D.J.; Schurgers, L.J.; Newman, P.. Vitamins and vitamin-like nutrients for prevention of human diseases. 2011.
  3. Schurgers, Leon. Vitamin K. In: Vitamins and vitamin-like nutrients for prevention of human diseases. Países Baixos. 2010.
    Publicado
  4. Schurgers, Leon. Large artery calcification. 2009.
    Publicado
  5. Schurgers, L.J.; Knapen, M.H.J.; Vermeer, C.. Vitamin K2 improves bone strength in postmenopausal women. 2007.
    10.1016/j.ics.2006.08.006
  6. Leunissen, Mariska. Direct testing for deficiencies. Oxford University Press. 2005.
    Publicado • 10.1093/acprof:oso/9780190602215.003.0006
  7. Schurgers, Leon. Vitamin K supplementation: a simple way to improve bone and vascular health. 2003.
    Publicado
  8. Schurgers, Leon. Potential applications of vitamin K-containing products. 2003.
    Publicado
  9. Schurgers, Leon. Vitamin K enrichment: a new challenge for functional foods that target vascular and bone health. 2002.
    Publicado
  10. Schurgers, Leon. Increased vitamin K intake by functional foods or food supplements: a new lead to improve cardiovascular and bone health. 2002.
    Publicado
  11. Schurgers, Leon. Vitamin K-enrichment: a new challenge for functional foods that target cardiovascular and bone health. 2002.
    Publicado
  12. Schurgers, Leon. Role of vitamin K in vascular mineralization and in reduction of arterial thrombosis. In: Vitamin K and aging. National Academies Press. 1998.
    Publicado • 10.17226/949
Tese / Dissertação
  1. "Studies on the role of vitamin K1 and K2 in bone metabolism and cardiovascular disease : structural differences determine different metabolic pathways". 2002. https://cris.maastrichtuniversity.nl/en/publications/c1210808-c49e-4c65-ac8d-23a893ce4ce8.
    10.26481/dis.20020621ls

Propriedade Intelectual

Patente
  1. Schurgers, Leon. 2006. "Pharmaceutical and nutraceutical products comprising vitamin K2".
    Permitida

Outros

Outra produção
  1. Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19. 2020. Anton S.M. Dofferhoff; Ianthe Piscaer; Leon J. Schurgers; Jona Walk; Jody M.W. van den Ouweland; Tilman M. Hackeng; Pim A. de Jong; et al. https://doi.org/10.20944/preprints202004.0457.v2.
    10.20944/preprints202004.0457.v2
  2. Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19. 2020. Anton S.M. Dofferhoff; Ianthe Piscaer; Leon J. Schurgers; Jona Walk; Jody M.W. van den Ouweland; Tilman M. Hackeng; Petra Lux; et al. https://doi.org/10.20944/preprints202004.0457.v1.
    10.20944/preprints202004.0457.v1
  3. MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. 2019. Kim van Kuijk; T. Theelen; J. Demandt; E. Marsch; Marion Gijbels; H. Jin; C. Reutelingsperger; et al. https://cris.maastrichtuniversity.nl/en/publications/dbf2a79b-6afb-4804-967a-391b1ceaddb6.
    10.1016/j.atherosclerosis.2019.06.027
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020 Heart Valve Society VAE 2020
2020 7th Annual Stem Cell Science Symposium
2020 ERA-EDTA European renal Osteodystrophy (EUROD) winter meeting Leuven
2019 Vascular inflammation, calcification and fibrosis: Role for vascular smooth muscle cell phenotypic switching MCCT Maastricht 2019
2019 Cardiovascular Calcification: how to prevent and treat Sao Paulo Cardiology meeting 2019
2019 Vascular calcification: Innocent bystander or culprit risk factor? State of the art lecture Glasgow ECTH 2019
2019 Meet the expert Glasgow ECTH 2019
2019 Calcification and treatment with vitamin K antagonists NVTH PHD course 2019
2019 The Netherlands Heart Institute Thema middag
2018 Hard disease and the vasculature: rocking between epidemiological clinical and basic science. 2nd Translation Cardiovascular Research Meeting - The Netherlands Heart Institute
2018 Exosome-mediated vascular calcification ESC Munich 2018
2018 Clinical consequence of vitamin K deficiency New York 2018
2018 Vitamin K and vascular ageing mechanisms Workshop INTRICARE Stockholm 2018
2018 Vascular calcification: a modifiable risk factor Workshop CaReSyAn Frankfurt 2018
2018 Effects of vitamin K and vitamin K antagonists on arterial calcification and vascular stiffening 11th international workshop on structure and function of the vascular system.
2017 Role of Vitamin K in vascular calcifications Lebanese Nephrology congress
2017 Role of Vitamin K in arterial calcifications and cardiovascular diseases Pisa Artery congress
2017 Vitamin K-deficiency – does it promote vascular calcification ERA EDTA symposium Madrid
2016 Clinical consequeces of vitamin K deficiency ASN symposium Chicago
2016 The infernal triad: matrix Gla protein, vitamin K and vascular calcification ERA EDTA symposium
2016 Vascular calcification: from innocent bystander to culprit riskfactor Program NCCS Workshop in Pune
2015 Vitamin K: Connection between coagulation and calcification Aachen 2015. HIA and DGBM symposium
2015 Vascular calcification: from innocent bystander to culprit risk factor Aachen 2015 Cardiovascular seminar “IMCARIM”
2015 Menaquinone-7 – a novel treatment option for cardiovascular disease Las Vegas Supply Side West 2015
2015 Vascular calcification: The price to pay for anticoagulation with vitamin K-antagonists GHSSH Bern 2015
2015 Finding Calcium in the non-calcified atherosclerotic lesion: insight into atheroma evolution using preclinical and clinical approaches CARIM dag 2015
2015 Vascular smooth muscle cell mediated calcification Cologne, Cardiovascular seminar 2015
2015 Vitamin K and Calcification FASEB, Vitamin K meeting Chigago 2015
2015 Vascular calcification: from innocent bystander to culprit risk factor Grand Rounds Carim 2015
2015 Deficiency of calcification inhibitors Calcyphylaxis expert meeting Leuven, 2015
2015 Vascular calcification: from innocent bystander to culprit risk factor DGAF, Raichholzhauzen 2015
2014 Vascular calcification: The price to pay for anticoagulation with vitamin K-antagonists Krakow 2014 (Jagiellonian Centre for Experimental Therapeutics)
2014 Vitamin K-antagonists: A two edged sword bi-phasic effect of VKA on atherosclerotic plaque development Longyearbyen 2014, Norway (1st Venous thrombosis meeting)
2014 Vitamin K and Vascular calcification: new treatment options? NMRD 2014 Wurzburg
2014 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists GTH 2014 Vienna
2013 Vascular smooth muscle cell phenotypic switching: importance for vascular calcification Cardiovascular Network Retreat, Rauischholzhausen 2013
2012 Strategies for prevention and regression of vascular calcification: new treatment options? ECS 2012 Munich
2012 Vascular calcification: new treatment options? ECS 2012 Munich
2012 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists Grand Rounds Carim 2012
2012 Vascular calcification: the price to pay for anticoagulation with vitamin K-antagonists NIGRAM 2012
2011 The role of vitamin K and vitamin K-dependent proteins in the arterial vessel wall NVTH 2011 The Netherlands
2011 The role of vitamin K in arterial calcification FASEB 2011 Arizona
2011 Vascular Calcification Abbott 2011 Barcelona
2011 Role of vitamin K in vascular calcification GTH 2011 Wiesbaden
2010 Vascular calcifications as a risk factor for cardiovascular mortality ERA-EDTA Munich, 2010
2010 Vascular calcification in Dialysis: modulated by vitamin K-status?
Belgium Nephrology symposium 2010
2010 Vascular calcification in Chronic Kidney Disease: importance of vitamin K-status Dutch Nephrology symposium 2010
2008 Vitamin K: a modifiable risk factor” American Society of Nephrology 2008. Plenary lecture
2008 MGP: the calcification inhibitor in need of vitamin K” Angers, France 2008
2008 MGP and Vitamin K: importance for vascular health” 2008 Sendai (Japan)
2007 “Function of vitamin K and MGP in pseudoxanthoma elastica” EuroPXE, Budapest, 2007
2006 Vitamin K2: cardiovascular and bone health benefits beyond K1” Supply Side East, New Jersey 2006
2002 Vitamin K: Friend or foe in cardiovascular disease Tübingen 2002
2002 Oral anticoagulants: Friend or foe in cardiovascular disease XVIth International Symposium on Haemostasis, Cairo, January 5-9, 2002
2001 Differential metabolic pathways for K-vitamins. FASEB Summer Research Conference on Vitamin K, Saxtons River, USA. 2001
2001 Differential metabolic pathways for K-vitamins in vascular calcification Workshop on vascular calcification. 2001. Wittenberg, Germany
2001 Potential involvement of vitamin K-dependent Matrix Gla-Protein (MGP) in ectopic calcification XIVth Aachen Colloquim on Biomaterials. 2001
2000 Role of vitamin K in vascular calcification Workshop on vascular calcification. 2000. Wittenberg, Germany
1999 Relationship of vitamin K intake to bone health Vitamins A & K Workshop, organized by the Panel on Micronutrients, Food and Nutrition Board, National Academy of Sciences Institute of Medicine, Washington, USA, 1999

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2015 - Atual Role of vascular smooth muscle cell mediated calcification in atherosclerosis
Coorientador
2015 - Atual Annexin A1 and annexin A5 in cardiovascular disease
Coorientador
2013 - Atual Phosphatidylserine targeting for diagnosis and treatment of human diseases
Coorientador
2011 - Atual Vascular calcifications and Matrix Gla Protein in Hypertensive Subjects
Coorientador
2011 - Atual Development and validation of circulating matrix Gla-protein as biomarker for vascular disease: a modifiable inhibitor of vascular calcification
Coorientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2015 - Atual Organizing Committee of the FASEB summer course on vitamin K (Chicago, 2015) (2015)
Outro (Membro da Comissão Científica)
2015 - 2015 Organizing Committee of the 8th international Annexin Conference (Maastricht, 2015) (2015)
Conferência (Membro da Comissão Científica)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2015 - Atual Nutrients (2072-6643) MDPI AG

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2017 - Atual Coordinator Geneeskunde blok 1.5 Verteer en Verweer FHML (GEN, vice-coordinator ITM) Maastricht Universitair Medisch Centrum+, Países Baixos
2017 - Atual Tutor and lecturer Block 2.6
2011 - Atual Coordinator pre-medicine Course Biochemistry (UCM)
2011 - Atual Tutor Medicine Course 1.5 (ITM and regular)
2015 - 2017 Coordinator Medicine Course 1.5 Digestion and Defense FHML (ITM, vice-coordinator GEN)

Membro de associação

Nome da associação Tipo de participação
2019/01/01 - 2020 American Society of Nephrology Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2001 - Atual Member of the Nederlandse Vereniging voor Thrombose en Hemostase
Membro
1999 - Atual Member of the International Society for Thrombosis and Haemostasis (ISTH)
Membro
2001 - 2007 American Society of Bone and Mineral Research
Membro
2001 - 2005 American Heart Association
Membro
Distinções

Prémio

2019 CARIM Seed grant with University California Irvine (UCI) to establish a collaboration on the role of vitamin K dependent MGP and arteriovenous malformations (AVM)
2019 Rogier Veltrop – CARIM HS-BAFTA award (6 month travel grant)
2019 Asim Cengiz Akbulut – CARIM HS-BAFTA award (6 month travel grant)
2017 2017 Maurice Halder – Unilever Research Price 2017 “Arterial remodeling: a key player in cardiovascular disease” Master student
2017 2017 Rick van Gorp – Best Poster price CARIM symposium
2017 2017 Rick van Gorp – Abstract price NVTH
2016 2016 Martijn Chatrou – Thesis dissertation price CARIM
2015 2015 Rick van Gorp – Abstract Price NVTH