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Vasco C. Romão, MD PhD, is Invited Assistant Professor of Rheumatology at University of Lisbon Medical School (FMUL), an academic rheumatologist at Centro Hospitalar Universitário Lisboa Norte (CHULN), and a post-doctoral researcher at Instituto de Medicina Molecular. He got his Integrated MSc in Medicine in 2009 at FMUL, obtained two postgraduate Clinical Scholars Research Training Certificate Programs of the Harvard Medica School-Portugal Partnership (2013 & 2014), completed the Rheumatology Internship at CHULN (2018) and in 2020 he obtained his PhD degree in Medicine-Rheumatology at University of Lisbon Medical School. His main clinical and research focus is the pathophysiology and management of Sjögren’s syndrome (SS) and rheumatoid arthritis (RA). He has been deeply involved in the study of synovial pathobiology in RA, having participated in the ground-breaking R4RA study recently published in The Lancet and in the EULAR recommendations for synovial tissue research. He set up the SS Multidisciplinary Clinic in 2015, where more than 600 patients have been assessed to date, and he is the PI of the SS Biobank-IMM collection and of the CHULN-based OLISSYPO SS cohort (~300 patients). He is currently the co-chair of the Portuguese Systemic Rheumatic Diseases Study Group (GEDRESIS) and co-chair of the SS WG in the European Reference Network ReCONNET. He was part of the task force elaborating the EULAR recommendations for the treatment of SS as well as of the SS Big Data Consortium, with over 10,000 patients. He co-supervises 2 PhD students (since 2020) and supervised 6 MSc students (since 2015). He is the clinical supervisor of a rheumatology fellow (since Jan 2020). He is co-author of 50 SCI publications, h-index=17 (https://scholar.google.pt/citations?user=B0aS7WYAAAAJ&hl=pt-PT).
Identification

Personal identification

Full name
Vasco C Romão
Gender
Male

Citation names

  • Romão, Vasco
  • Romao VC

Author identifiers

Ciência ID
771D-0A5C-626B
ORCID iD
0000-0002-5603-9436

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Rheumatology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Advanced (C1) Intermediate (B1) Intermediate (B1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2014/05 - 2020/07
Concluded
Medicina (Doutoramento)
Major in Rheumatology
Universidade de Lisboa Faculdade de Medicina, Portugal
"Synovial pathobiology and patient stratification in Rheumatoid Arthritis" (THESIS/DISSERTATION)
Unanimously approved Cum Laude
2019/02
Concluded
EUSTAR Course on Systemic Sclerosis (Pós-Graduação)
European League Against Rheumatism, Switzerland
2012/01/01 - 2018/10/30
Concluded
Rheumatology Internship (Título de especialista)
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
19.8 / 20
2018/04
Concluded
Salivary Gland Ultrasonography in Sjögren’s Syndrome: Theory and Practice Workshop (Especialização pós-licenciatura)
Johns Hopkins Medicine, United States
2017/12
Concluded
EMEUNET Peer Review Mentoring Program (Especialização pós-licenciatura)
European League Against Rheumatism, Switzerland
2017/10
Concluded
FLxFlow Course - Principles and Applications of Flow Cytometry (Especialização pós-licenciatura)
Instituto de Medicina Molecular, Portugal
2017/06
Concluded
EULAR European Certificate of Rheumatology (Especialização pós-licenciatura)
European League Against Rheumatism, Switzerland
84%
2017/05
Concluded
EULAR Scientifically Endorsed Course on Systemic Lupus Erythematosus (Pós-Graduação)
Clinical and Experimental Rheumatology S A S, Italy
2017/04
Concluded
Laboratory Animal Science (Especialização pós-licenciatura)
Instituto de Medicina Molecular, Portugal
86%
2016/11
Concluded
Advanced Life Support (Pós-Graduação)
European Resuscitation Council, Belgium
2016/04
Concluded
EULAR Immunology Course (Especialização pós-licenciatura)
European League Against Rheumatism, Switzerland
2015/11
Concluded
Bioimaging NanoCourse on Microscopy (Especialização pós-licenciatura)
Instituto de Medicina Molecular, Portugal
2015/11
Concluded
Flow Cytometry CAML Advanced Course (Especialização pós-licenciatura)
Instituto de Medicina Molecular, Portugal
2012/09/01 - 2015/09/30
Concluded
EULAR On-line Course on Rheumatic Diseases (Pós-Graduação)
European League Against Rheumatism, Switzerland
89%
2014/01/01 - 2014/12/31
Concluded
Clinical Scholars Research Training Certificate Program II (Pós-Graduação)
Harvard Medical School, United States
Approved
2013/01/01 - 2013/12/31
Concluded
Clinical Scholars Research Training Certificate Program I (Pós-Graduação)
Harvard Medical School, United States
Approved
2013/07 - 2013/07
Concluded
EULAR Epidemiology Course (Pós-Graduação)
European League Against Rheumatism, Switzerland
2012/09/14 - 2012/09/16
Concluded
Intermediate Musculoskeletal Ultrasound Course (Pós-Graduação)
Sociedade Portuguesa de Reumatologia, Portugal
2012/01/27 - 2012/01/29
Concluded
II Basic Musculoskeletal Ultrasound Course (Pós-Graduação)
Sociedade Portuguesa de Reumatologia, Portugal
2009
Concluded
Integrated Master in Medicine (Mestrado integrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Avaliação do efeito dos agregados de LPS na velocidade de hemólise." (THESIS/DISSERTATION)
18/20
Affiliation

Science

Category
Host institution
Employer
2012/01/01 - Current Researcher (Research) Instituto de Medicina Molecular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2020/11 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020/10 Invited Assistant (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal

Other Careers

Category
Host institution
Employer
2018/11 - Current Assistente (Médica) Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Hospital de Santa Maria, Portugal

Others

Category
Host institution
Employer
2017 - 2019 Pharmacovigilance Delegate Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2012/01/01 - 2018/10/31 Rheumatology Fellow Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2013/05/01 - 2015/01/31 EMEUNET Country Liaison (Portugal) European League Against Rheumatism, Switzerland
2013/01/01 - 2014/12/31 Harvard Medical School Portugal Clinical Scholars Research Training Program Fellow Harvard Medical School, United States
2014/02/01 - 2014/07/31 Clinical Research Fellow Barts and The London School of Medicine and Dentistry William Harvey Research Institute, United Kingdom
2011/01/01 - 2011/12/31 General Medical Fellow Centro Hospitalar de Lisboa Central EPE, Portugal
Projects

Grant

Designation Funders
2019 - Current 3TR - Taxonomy, Treatment, Targets and Remission. Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions
IMI - 3TR
Researcher
2016 - 2021 Blood biomarkers of synovial tissue phenotype as predictors of response to TNF inhibitors and tocilizumab in rheumatoid arthritis.
SPR 2016
Principal investigator
2016 - 2021 IL-6-blockade in rheumatoid arthritis patients: impact on Tfh subsets and humoral responses.
SPR 2016
Principal investigator
2014 - 2019 Clinical, pathobiological and immunogenetic differences in elderly- and younger onset rheumatoid arthritis.
Fundo SPR 2015 2016
PhD Student Fellow
2014 - 2018 R4RA Trial
R4RA
Research Fellow
2012 - 2016 Tuberculosis prevention in patients with immune mediated inflammatory diseases treated with biological therapy
CHULN 2013
Principal investigator

Contract

Designation Funders
2020 - Current linical course and predictors of severe coronavirus disease 19 among patients with rheumatic diseases in portugal – a multicentre, observational, nationwide study
COVID ReumapT
Principal investigator
2023/02/01 - 2024/07/31 Revelando os eventos moleculares de desregulação imunológica levando ao linfoma associado à Síndrome de Sjögren
2022.05498.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2021 - Current CovidVac - Caracterização da imunidade neutralizante de indivíduos vacinados para a COVID-19 ao longo de 12 meses
Covidvac
Principal investigator
2021 - Current Vacinação COVID em doenças raras e complexas do tecido conjuntivo: estudo observacional prospetivo multicêntrico (VACCINATE)
Vaccinate
Researcher
2019 - Current TWINSS (CFZ533B2201): A 48-week, 6-arm randomized controlled trial of CFZ533 in two distinct patient populations with Sjögren’s Syndrome to assess the safety and efficacy of multiple CFZ533 doses administered subcutaneously.
TWINSS
Principal investigator
2018 - Current Immune response to Hepatitis B and Influenza vaccines in rheumatic patients under biological therapies.
HBV immune
Supervisor
2017 - Current B cells in Juvenile Idiopathic Arthritis: effect of immunosuppressive treatment
B CELLS JIA
Researcher
2015 - Current OLISSYPO Cohort
OLYSSIPO
Principal investigator
2014 - Current Impact of Dysregulated Follicular Helper T (Tfh) Cell Subsets in Human Autoimmunity
Tfh
Researcher
2021 - 2022 Off-label use of mycophenolate mofetil in the treatment of rare and complex rheumatic connective tissue diseases
MMF
Principal investigator
2018 - 2022 STRAP: Stratification of Biologic Therapies for RA by Pathobiology: A randomised, open- labelled biopsy-driven stratification trial in DMARD inadequate responder patients randomised to Etanercept, Tocilizumab or Rituximab.
STRAP
Researcher
2017 - 2019 CVAY736A2201: A randomized, double-blind, placebo-controlled multicenter phase 2 dose-ranging study to assess the safety and efficacy of multiple VAY736 doses administered subcutaneously in patients with moderate to severe primary Sjögren’s Syndrome.
CVAY
Researcher
2017 - 2018 SÖURCE (BP30037): A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Parallel Group Phase 2A Study To Assess The Efficacy of RO5459072 In Patients With Primary Sjögren’s Syndrome
SOURCE
Researcher
2015 - 2018 R4RA: A Randomised, open labelled study in anti-TNFa inadequate responders to investigate the mechanisms for Response - Resistance to Rituximab versus Tocilizumab in RA
R4RA
Researcher
2012 - 2017 EULAR/ACR Diagnostic and Classification Criteria in Vasculitis study.
DCVAS
Researcher
2015 - 2016 Protocolo Reuma.pt — Síndrome de Sjögren
SS ReumaPT
Principal investigator
2014 - 2015 TO SPACE (ML28790): Multi-national, multicentre open-label, phase IIIb study to evaluate the efficacy, tolerability and safety of SC TCZ, administered as monotherapy or in combination with oral /SC MTX or other nbDMARDs, in patients with active RA with an inadequate response to nbDMARDs or to one an
TOSPACE
Researcher
2013 - 2015 Lúpus eritematoso sistémico em Portugal: caracterização de subpopulações com início precoce e tardio de doença.
SLE GENDER
Researcher
2013 - 2015 Avaliação de dano e a sua associação a fatores clínicos e laboratoriais de doentes com LES em Portugal.
SLE DAMAGE
Researcher
2014 - 2014 I4V-MC-JADV: A Randomized, Double-Blind, Placebo- and Active-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib in Patients with Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate Therapy.
I4V-MC-JADV
Researcher
2013 - 2014 Comparação da Sensibilidade dos Critérios de Classificação ACR 1997 e SLICC 2012 para LES.
LES ACR SLICC
Researcher
2013 - 2014 Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome.
LUTS SS SLE
Principal investigator
2012 - 2014 Comparative effectiveness of tocilizumab and TNF inhibitors in rheumatoid arthritis patients.
TNF-TCZ
Researcher
2012 - 2013 Collaborative European Registries for the Evaluation of Rituximab in Rheumatoid Arthritis (CERERRA)
CERERRA
Researcher
Outputs

Publications

Book chapter
  1. Studenic P; Romao VC; Patrick Verschueren. "Measuring disease activity and damage in inflammatory arthritis.". In EULAR Textbook on Rheumatic Diseases. 2020.
  2. Romao VC. "EMEUNET – The Emerging EULAR Network.". In Manual do Interno, 2a Edição, 78-79. 2016.
  3. Romao VC. "Estrutura do Internato em Reumatologia". In Manual do Interno, 1a edição, 8-9. 2012.
Journal article
  1. Brito-Zerón P; Flores-Chávez A; Horváth IF; Rasmussen A; Li X; Olsson P; Vissink A; et al. "Mortality risk factors in primary Sjögren syndrome: a real-world, retrospective, cohort study.". EClinicalMedicine (2023): http://europepmc.org/abstract/med/37457113.
    10.1016/j.eclinm.2023.102062
  2. Alunno A; Avcin T; Haines C; Ramiro S; Sivera F; Badreh S; Baraliakos X; et al. "Points to consider: EULAR-UEMS standards for the training of European rheumatologists.". Annals of the rheumatic diseases (2023): http://europepmc.org/abstract/med/37188497.
    10.1136/ard-2023-223941
  3. Talarico R; Ramirez GA; Barreira SC; Cardamone C; Triggianese P; Aguilera S; Andersen J; et al. "ERN ReCONNET points to consider for treating patients living with autoimmune rheumatic diseases with antiviral therapies and anti-SARS-CoV-2 antibody products.". Clinical and experimental rheumatology (2023): http://europepmc.org/abstract/med/36916322.
    10.55563/clinexprheumatol/jpargp
  4. Flores-Chavez A; Ng WF; Alunno A; Inanc N; Feijoo-Massó C; Seror R; Hernandez-Molina G; et al. "Characterisation of the coexistence between sarcoidosis and Sjögren's syndrome. Analysis of 43 patients.". Clinical and experimental rheumatology (2022): http://europepmc.org/abstract/med/36541233.
    10.55563/clinexprheumatol/pg964c
  5. Martins P; Dourado E; Melo AT; Samões B; Sousa M; Freitas R; Lourenço MH; et al. "Clinical characterisation of a multicentre nationwide cohort of patients with antisynthetase syndrome.". ARP rheumatology (2022): http://europepmc.org/abstract/med/35891592.
  6. Silvério-António M; Alves Ribeiro L; Medeiros J; Fonseca JE; Romão VC. "Sjögren's syndrome presenting as thrombotic thrombocytopenic purpura in a male patient with previous Kikuchi-Fujimoto disease.". Clinical and experimental rheumatology (2022): http://europepmc.org/abstract/med/36441648.
    10.55563/clinexprheumatol/utteqf
  7. Bandeira M; Romão VC. "Diagnosing Sjögren's disease in 2023: what is new?". ARP rheumatology (2022): http://europepmc.org/abstract/med/36617308.
  8. Ribeiro F; Romão VC; Rosa S; Jesus K; Água-Doce A; Barreira SC; Martins P; et al. "Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation.". Scientific reports (2022): http://europepmc.org/abstract/med/36271118.
    10.1038/s41598-022-21576-8
  9. Romão VC; Fonseca JE. "Disease mechanisms in preclinical rheumatoid arthritis: A narrative review.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/36059838.
    10.3389/fmed.2022.689711
  10. Cruz-Machado AR; Barreira SC; Bandeira M; Veldhoen M; Gomes A; Serrano M; Duarte C; et al. "Risk Factors for Infection, Predictors of Severe Disease, and Antibody Response to COVID-19 in Patients With Inflammatory Rheumatic Diseases in Portugal-A Multicenter, Nationwide Study.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/35770002.
    10.3389/fmed.2022.901817
  11. Rivellese F; Surace AEA; Goldmann K; Sciacca E; Çubuk C; Giorli G; John CR; et al. "Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.". Nature medicine (2022): http://europepmc.org/abstract/med/35589854.
    10.1038/s41591-022-01789-0
  12. Martins P; Dourado E; Fonseca JE; Romão V; Resende C. "The safety and persistence of intravenous iloprost in systemic sclerosis.". ARP rheumatology (2022): http://europepmc.org/abstract/med/35810370.
  13. Baldini C; Arnaud L; Avcin T; Beretta L; Bellocchi C; Bouillot C; Burmester GR; et al. "Sjögren's syndrome and other rare and complex connective tissue diseases: an intriguing liaison.". Clinical and experimental rheumatology (2022): http://europepmc.org/abstract/med/35349420.
    10.55563/clinexprheumatol/3y0hqs
  14. Talarico R; Aguilera S; Alexander T; Amoura Z; Andersen J; Arnaud L; Avcin T; et al. "The added value of a European Reference Network on rare and complex connective tissue and musculoskeletal diseases: insights after the first 5 years of the ERN ReCONNET.". Clinical and experimental rheumatology (2022): http://europepmc.org/abstract/med/35349419.
    10.55563/clinexprheumatol/d2qz38
  15. Bandeira M; Vieira A; Guimarães V; Bento T; Amoura Z; Arnaud L; Beretta L; et al. "Off-label use of mycophenolate mofetil in the treatment of rare and complex rheumatic connective tissue diseases.". Clinical and experimental rheumatology (2022): http://europepmc.org/abstract/med/35349418.
    10.55563/clinexprheumatol/v1e7s2
  16. Najm, Aurélie; Costantino, Félicie; Alivernini, Stefano; Alunno, Alessia; Bianchi, Elettra; Bignall, Jacqueline; Boyce, Brendan; et al. "EULAR points to consider for minimal reporting requirements in synovial tissue research in rheumatology". Annals of the Rheumatic Diseases (2022): annrheumdis-2021-221. http://dx.doi.org/10.1136/annrheumdis-2021-221875.
    Open access • 10.1136/annrheumdis-2021-221875
  17. Ugarte-Gil, Manuel Francisco; Alarcón, Graciela S; Izadi, Zara; Duarte-García, Ali; Reátegui-Sokolova, Cristina; Clarke, Ann Elaine; Wise, Leanna; et al. "Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance". Annals of the Rheumatic Diseases (2022): annrheumdis-2021-221. http://dx.doi.org/10.1136/annrheumdis-2021-221636.
    Open access • 10.1136/annrheumdis-2021-221636
  18. Bandeira, Matilde; Gil, Ângela; Santos, Ana Carolina; Romão, Vasco C.; Mascarenhas, Mário Rui; Filipe, Paulo; Fonseca, João Eurico; Bicho, Manuel. "Angiotensin-Converting Enzyme Activity May Predict Disease Severity in Psoriasis". Rheumato 2 1 (2022): 15-23. http://dx.doi.org/10.3390/rheumato2010003.
    Open access • 10.3390/rheumato2010003
  19. Romão, Vasco C; Khmelinskii, Nikita. Corresponding author: Romão, Vasco C. "Clinical and ultrasonographic features of erythema nodosum in Behçet’s disease". Rheumatology 15 1 (2022): 63. http://dx.doi.org/10.1093/rheumatology/keac035.
    10.1093/rheumatology/keac035
  20. Manuel Silvério-António; Vasco C Romão; Joaquim Polido-Pereira. "Late presentation of macrodystrophia lipomatosa—a rare, impressive diagnosis". Rheumatology (2021): https://doi.org/10.1093/rheumatology/keab314.
    Published • 10.1093/rheumatology/keab314
  21. Tenazinha C; Rita Barros; Romao VC; Barros R; Romão VC. Corresponding author: Romao VC. "Candida albicans tenosynovitis of the hand". Acta Reumatológica Portuguesa Online (2021): 2021-12-19. http://europepmc.org/abstract/med/35810380.
    Open access
  22. Romao VC; Fonseca, JE. Corresponding author: Fonseca, JE. "Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review". Frontiers in Medicine 8 (2021): http://dx.doi.org/10.3389/fmed.2021.689698.
    Open access • Published • 10.3389/fmed.2021.689698
  23. Brito-Zerón P; Acar-Denizli N; Romao VC; Armagan B; Seror R; Carubbi F; Melchor SIM; et al. Corresponding author: Ramos-Casals M. "Post-COVID-19 syndrome in patients with primary Sjögren's syndrome after acute SARS-CoV-2 infection.". Clinical and experimental rheumatology 39 Suppl 1 6 (2021): 57-65.
    Open access • Published
  24. Romão, Vasco C.; Fonseca, João Eurico; Pitzalis, Costantino. Corresponding author: Pitzalis, Costantino. "Elderly-onset rheumatoid arthritis is a unique disease subset associated with poor overall outcomes: Response to the letter by Haroon and Ayamer". Seminars in Arthritis and Rheumatism 51 5 (2021): e11-e12. http://dx.doi.org/10.1016/j.semarthrit.2020.09.015.
    Open access • Published • 10.1016/j.semarthrit.2020.09.015
  25. Romao V; Foletti JM; Guyot L; Campana F; Catherine JH; Lan R. "Increasingly frequent palatal perforation, what is your diagnosis?". Journal of stomatology, oral and maxillofacial surgery (2021): http://europepmc.org/abstract/med/34715406.
    10.1016/j.jormas.2021.10.012
  26. Fernandes BM; Guimarães F; Almeida DE; Neto A; Tavares-Costa J; Ribeiro AR; Quintal A; et al. Corresponding author: Bernardes M. "Portuguese recommendations for the use of biological and targeted synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis – 2020 update". ARP Rheumatology 1 1 (2021): 63-82. https://www.arprheumatology.com/section.php?id=1555.
    Open access • Published
  27. Martins P; Dourado E; Fonseca, JE; Cordeiro I; Romao VC; Resende C. "Ten years of a systemic sclerosis clinic in a tertiary referral centre - insights and future directions.". Acta Reumatológica Portuguesa 46 3 (2021): 257-265. http://actareumatologica.pt/article_download.php?id=1523.
    Open access • Published
  28. Leal Rato, Miguel; Bandeira, Matilde; Romão, Vasco C.; Aguiar de Sousa, Diana. Corresponding author: Leal Rato, Miguel. "Neurologic Manifestations of the Antiphospholipid Syndrome — an Update". Current Neurology and Neuroscience Reports 21 8 (2021): http://dx.doi.org/10.1007/s11910-021-01124-z.
    Published • 10.1007/s11910-021-01124-z
  29. Leal, Inês; Romão, Vasco C; Mano, Sofia; Khmelinskii, Nikita; Campanilho-Marques, Raquel; Ponte, Cristina; Macieira, Carla; et al. "A Non-Infectious Uveitis Multidisciplinary Clinic in a Tertiary Referral Center: Clinical Impact and Added Value". Journal of Multidisciplinary Healthcare Volume 14 (2021): 695-704. http://dx.doi.org/10.2147/jmdh.s292981.
    10.2147/jmdh.s292981
  30. Talarico, Rosaria; Aguilera, Silvia; Alexander, Tobias; Amoura, Zahir; Antunes, Ana M.; Arnaud, Laurent; Avcin, Tadej; et al. Corresponding author: Mosca M. "The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET". Nature Reviews Rheumatology 17 3 (2021): 177-184. http://dx.doi.org/10.1038/s41584-020-00565-z.
    Published • 10.1038/s41584-020-00565-z
  31. Humby, Frances; Durez, Patrick; Buch, Maya H; Lewis, Myles J; Rizvi, Hasan; Rivellese, Felice; Nerviani, Alessandra; et al. Corresponding author: Pitzalis, Costantino. "Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial". The Lancet 397 10271 (2021): 305-317. http://dx.doi.org/10.1016/s0140-6736(20)32341-2.
    Open access • Published • 10.1016/s0140-6736(20)32341-2
  32. Romão, Vasco C.; Polido-Pereira, Joaquim; Barros, Rita; Luís, Rita; Vidal, Bruno; Vieira-Sousa, Elsa; Vitorino, Emília; et al. Corresponding author: Fonseca, João Eurico. "Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study". Arthritis Care & Research 72 10 (2020): 1497-1505. http://dx.doi.org/10.1002/acr.24050.
    10.1002/acr.24050
  33. Romao VC; Oliveira-Ramos F; Ana Rita Cruz-Machado; Martins P; Barreira S; Silva-Dinis J; Mendonca-Galaio, Luis; et al. Corresponding author: Fonseca, JE. "A COVID-19 Outbreak in a Rheumatology Department Upon the Early Days of the Pandemic.". Frontiers in medicine 7 (2020): 576162. https://europepmc.org/articles/PMC7546334.
    Open access • Published • 10.3389/fmed.2020.576162
  34. Cascão, Rita; Vidal, Bruno; Carvalho, Tânia; Lopes, Inês Pascoal; Romão, Vasco C.; Goncalves, João; Moita, Luis Ferreira; Fonseca, João Eurico. "Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model". Frontiers in Medicine 7 (2020): 455. http://dx.doi.org/10.3389/fmed.2020.00455.
    Open access • Published • 10.3389/fmed.2020.00455
  35. Romão, Vasco C.; Humby, Frances; Kelly, Stephen; Di Cicco, Maria; Mahto, Arti; Lazarou, Ilias; Hands, Rebecca; et al. "Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study". Seminars in Arthritis and Rheumatism 50 4 (2020): 735-743. http://dx.doi.org/10.1016/j.semarthrit.2020.03.018.
    Published • 10.1016/j.semarthrit.2020.03.018
  36. Romão, Vasco C; Cruz-Machado, Ana Rita; Fonseca, João Eurico. "Response to: ‘The role of antimalarials in COVID-19: observational data from a cohort of rheumatic patients’ by Favalli et al". Annals of the Rheumatic Diseases 80 5 (2020): e76. http://dx.doi.org/10.1136/annrheumdis-2020-218175.
    Open access • Published • 10.1136/annrheumdis-2020-218175
  37. Romão, Vasco C; Cordeiro, Inês; Macieira, Carla; Oliveira-Ramos, Filipa; Romeu, José Carlos; Rosa, Carlos Miranda; Saavedra, Maria João; et al. "Rheumatology practice amidst the COVID-19 pandemic: a pragmatic view". RMD Open 6 2 (2020): e001314. http://dx.doi.org/10.1136/rmdopen-2020-001314.
    Open access • Published • 10.1136/rmdopen-2020-001314
  38. Monti, Sara; Craven, Anthea; Klersy, Catherine; Montecucco, Carlomaurizio; Caporali, Roberto; Watts, Richard; Merkel, Peter A; et al. "Association between age at disease onset of anti-neutrophil cytoplasmic antibody–associated vasculitis and clinical presentation and short-term outcomes". Rheumatology 60 2 (2020): 617-628. http://dx.doi.org/10.1093/rheumatology/keaa215.
    Published • 10.1093/rheumatology/keaa215
  39. Romão, Vasco C.; Cruz-Machado, Ana Rita; Fonseca, João Eurico. "No evidence so far on the protective effect of hydroxychloroquine to prevent COVID-19: comment by Joob and Wiwanitkit". Annals of the Rheumatic Diseases 80 2 (2020): e22-e22. http://dx.doi.org/10.1136/annrheumdis-2020-217665.
    Open access • Published • 10.1136/annrheumdis-2020-217665
  40. Ramos-Casals, Manuel; Brito-Zerón, Pilar; Bombardieri, Stefano; Bootsma, Hendrika; De Vita, Salvatore; Dörner, Thomas; Fisher, Benjamin A; et al. "EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies". Annals of the Rheumatic Diseases 79 1 (2019): 3-18. http://dx.doi.org/10.1136/annrheumdis-2019-216114.
    Open access • Published • 10.1136/annrheumdis-2019-216114
  41. Valido A; Silva-Dinis J; Cruz-Machado AR; Gonçalves MJ; Romao VC; Saavedra MJ; Fonseca, JE. Corresponding author: Fonseca, JE. "Loss to follow-up in registries of rheumatic patients treated with biologics: a potential information bias in assessing pharmacovigilance and efficacy outcomes.". Acta reumatologica portuguesa 44 4 (2019): 281-287.
    Open access • Published
  42. Romão, Vasco C.; Fonseca, João Eurico. Corresponding author: Fonseca, João Eurico. "Major Challenges in Rheumatology: Will We Ever Treat Smarter, Instead of Just Harder?". Frontiers in Medicine 6 (2019): 144. http://dx.doi.org/10.3389/fmed.2019.00144.
    Open access • Published • 10.3389/fmed.2019.00144
  43. Leal, Inês; Rodrigues, Filipe B.; Sousa, David Cordeiro; Duarte, Gonçalo S.; Romão, Vasco C.; Marques-Neves, Carlos; Costa, João; Fonseca, João Eurico. Corresponding author: Fonseca, João Eurico. "Anti-TNF Drugs for Chronic Uveitis in Adults—A Systematic Review and Meta-Analysis of Randomized Controlled Trials". Frontiers in Medicine 6 (2019): 104. http://dx.doi.org/10.3389/fmed.2019.00104.
    Published • 10.3389/fmed.2019.00104
  44. Pereira e Silva, R.; Romão, V.C.; Neves, M.; Garcia, R.; Oliveira, S.; Brites, J.; Ramos, F.O.; et al. "Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome". Lupus 28 1 (2019): 27-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059002898&partnerID=MN8TOARS.
    Open access • Published • 10.1177/0961203318811605
  45. Najm, Aurélie; Le Goff, Benoît; Orr, Carl; Thurlings, Rogier; Cañete, Juan D.; Humby, Frances; Alivernini, Stefano; et al. "Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups". Arthritis Research & Therapy 20 1 (2018): 265. http://dx.doi.org/10.1186/s13075-018-1762-1.
    Open access • Published • 10.1186/s13075-018-1762-1
  46. Romão, Vasco C; Talarico, Rosaria; Scirè, Carlo Alberto; Vieira, Ana; Alexander, Tobias; Baldini, Chiara; Gottenberg, Jacques-Eric; et al. "Sjögren’s syndrome: state of the art on clinical practice guidelines". RMD Open 4 Suppl 1 (2018): e000789. http://dx.doi.org/10.1136/rmdopen-2018-000789.
    Open access • Published • 10.1136/rmdopen-2018-000789
  47. Fonseca, Valter R.; Romão, Vasco C.; Fonseca, João Eurico; Agua-Doce, Ana; Graca, Luis. "Reply". Arthritis & Rheumatology 70 8 (2018): 1355-1356. http://dx.doi.org/10.1002/art.40487.
    Published • 10.1002/art.40487
  48. Humby, Frances; Romão, Vasco C.; Manzo, Antonio; Filer, Andrew; Bugatti, Serena; Vieira-Sousa, Elsa; Kelly, Stephen; et al. "A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis". Arthritis & Rheumatology 70 5 (2018): 702-710. http://dx.doi.org/10.1002/art.40433.
    Published • 10.1002/art.40433
  49. Romão, V.C.; Fonseca, J.E.; Agua-Doce, A.; Graca, L.. "T Follicular Regulatory Cells Are Decreased in Patients With Established Treated Rheumatoid Arthritis With Active Disease: Comment on the Article by Liu et al". Arthritis and Rheumatology 70 11 (2018): 1893-1895. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052967613&partnerID=MN8TOARS.
    Published • 10.1002/art.40586
  50. Fonseca, V.R.; Romão, V.C.; Agua-Doce, A.; Santos, M.; López-Presa, D.; Ferreira, A.C.; Fonseca, J.E.; Graca, L.. "The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome". Arthritis and Rheumatology 70 5 (2018): 774-784. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045876259&partnerID=MN8TOARS.
    Published • 10.1002/art.40424
  51. Leal, Inês; Rodrigues, Filipe B.; Sousa, David Cordeiro; Romão, Vasco C.; Duarte, Gonçalo S.; Carreño, Ester; Dick, Andrew D.; et al. "Efficacy and safety of intravitreal anti-tumour necrosis factor drugs in adults with non-infectious uveitis : a systematic review". Acta Ophthalmologica 96 6 (2018): e665-e675. http://hdl.handle.net/10451/33065.
    Published • 10.1111/aos.13699
  52. Moura, Rita A.; Quaresma, Cláudia; Vieira, Ana R.; Gonçalves, Maria J.; Polido-Pereira, Joaquim; Romão, Vasco C.; Martins, Nádia; Canhão, Helena; Fonseca, João E.. "B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis". PLOS ONE 12 9 (2017): e0182927. http://dx.doi.org/10.1371/journal.pone.0182927.
    Published • 10.1371/journal.pone.0182927
  53. Sousa S; Duarte AC; Cordeiro I; Ferreira J; Gonçalves MJ; Meirinhos T; Rocha TM; Romao VC; Santos MJ. "Efficacy and Safety of Vaccination in Pediatric Patients with Systemic Inflammatory Rheumatic Diseases: a systematic review of the literature.". Acta reumatologica portuguesa 42 1 (2017): 8-16. http://europepmc.org/abstract/med/28133957.
    Open access • Published
  54. Romão, V.C.; Vital, E.M.; Fonseca, J.E.; Buch, M.H.. "Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?". Arthritis research & therapy 19 1 (2017): 239-239. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049097905&partnerID=MN8TOARS.
    Published • 10.1186/s13075-017-1445-3
  55. Gonçalves, M.J.; Romão, V.C.; Soares-de-Almeida, L.; Canhão, H.; Romeu, J.C.; Kutzner, H.; Pereira-da-Silva, J.A.. "Erythema elevatum diutinum in Crohn's disease-associated spondyloarthritis - A rare vasculitis, an unusual association". Acta Reumatologica Portuguesa 42 4 (2017): 324-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-85039839280&partnerID=MN8TOARS.
    Published
  56. Fonseca, Valter; Agua-Doce, Ana; Maceiras, Ana Raquel; Pierson, Wim; Ribeiro, Filipa; Romão, Vasco; Pires, Ana Rita; et al. "Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function". Science Immunology 2 14 (2017): eaan1487-eaan1487. http://hdl.handle.net/10451/28765.
    Published • 10.1126/sciimmunol.aan1487
  57. Beyer, Christian; Ramiro, Sofia; Sivera, Francisca; Mandl, Peter; Machado, Pedro M; Ospelt, Caroline; Moltó, Anna; et al. "Educational needs and preferences of young European clinicians and physician researchers working in the field of rheumatology". RMD Open 2 2 (2016): e000240. http://dx.doi.org/10.1136/rmdopen-2015-000240.
    Published • 10.1136/rmdopen-2015-000240
  58. Sousa, S.; Gonçalves, M. J.; Inês, L. S.; Eugénio, G.; Jesus, D.; Fernandes, S.; Terroso, G.; et al. "Clinical features and long-term outcomes of systemic lupus erythematosus: comparative data of childhood, adult and late-onset disease in a national register". Rheumatology International 36 7 (2016): 955-960. http://dx.doi.org/10.1007/s00296-016-3450-2.
    Open access • Published • 10.1007/s00296-016-3450-2
  59. Cordeiro I; Duarte AC; Ferreira JF; Gonçalves MJ; Meirinhos T; Rocha TM; Romao VC; et al. "Recommendations for Vaccination in Adult Patients with Systemic Inflammatory Rheumatic Diseases from the Portuguese Society of Rheumatology.". Acta reumatologica portuguesa 41 2 (2016): 112-130. http://europepmc.org/abstract/med/27606471.
    Open access • Published
  60. Inês, Luís; Silva, Cândida; Galindo, Maria; López-Longo, Francisco J.; Terroso, Georgina; Romão, Vasco C.; Rúa-Figueroa, Iñigo; et al. "Classification of Systemic Lupus Erythematosus: Systemic Lupus International Collaborating Clinics Versus American College of Rheumatology Criteria. A Comparative Study of 2,055 Patients From a Real-Life, International Systemic Lupus Erythematosus Cohort". Arthritis Care & Research 67 8 (2015): 1180-1185. http://dx.doi.org/10.1002/acr.22539.
    Published • 10.1002/acr.22539
  61. Romao VC; Santos, Maria José; Polido-Pereira, Joaquim; Duarte, Cátia; Nero, Patrícia; Miguel, Cláudia; Costa, José António; et al. "Comparative Effectiveness of Tocilizumab and TNF Inhibitors in Rheumatoid Arthritis Patients: Data from the Rheumatic Diseases Portuguese Register, Reuma.pt". BioMed Research International 2015 (2015): 279890. http://dx.doi.org/10.1155/2015/279890.
    Open access • Published • 10.1155/2015/279890
  62. Romao VC; Pitzalis, C.. "Synovial heterogeneity in rheumatoid arthritis: The key for rational patient stratification?". Acta Reumatologica Portuguesa 40 1 (2015): 6-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930146096&partnerID=MN8TOARS.
    Open access • Published
  63. Romao VC; Aurea Lima; Miguel Bernardes; Helena Canhão; João Eurico Fonseca. "Three decades of low-dose methotrexate in rheumatoid arthritis: Can we predict toxicity?". Immunologic Research 60 2-3 (2014): 289-310. https://doi.org/10.1007%2Fs12026-014-8564-6.
    Published • 10.1007/s12026-014-8564-6
  64. Gonçalves, M J; Sousa, S; Inês, L S; Duarte, C; Borges, J; Silva, C; Romão, V C; et al. "Characterization of damage in Portuguese lupus patients: analysis of a national lupus registry". Lupus 24 3 (2014): 256-262. http://dx.doi.org/10.1177/0961203314555172.
    Published • 10.1177/0961203314555172
  65. Maria João Gonçalves; Romao VC. "Saber Tibia in Paget's Disease of Bone". New England Journal of Medicine 371 25 (2014): 2417-2417. https://doi.org/10.1056%2Fnejmicm1403255.
    Published • 10.1056/nejmicm1403255
  66. Romao VC; Canhão, Helena; Fonseca, João Eurico. "Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?". BMC Medicine 11 (2013): 17. http://dx.doi.org/10.1186/1741-7015-11-17.
    Open access • Published • 10.1186/1741-7015-11-17
Magazine article
  1. Romao VC. "COVID-19 e doenças reumáticas: desafios e oportunidades.", Boletim Informativo da SPR, 2020
Manual
  1. Carvalho C; Romao VC; Barcelos F; Oliveira-Ramos O; Martins AL; Narciso L; Lopes F; Fonseca, JE. Manual informativo para o doente com Síndrome de Sjögren. Sociedade Portuguesa de Reumatologia. 2015.
Thesis / Dissertation
  1. "Synovial pathobiology and patient stratification in rheumatoid arthritis". PhD, Universidade de Lisboa Faculdade de Medicina, 2020. http://hdl.handle.net/10451/48551.
  2. "Avaliação do efeito dos agregados de LPS na velocidade de hemólise". Master, Universidade de Lisboa Faculdade de Medicina, 2009.
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021 - Current Gastrointestinal Involvement in Patients with Systemic Sclerosis
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - Current Caracterização da população de doentes com Esclerose Sistémica seguidas em consulta de Reumatologia no Hospital de Santa Maria
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - Current Immune response to hepatitis B and influenza vaccines in patients under biological therapies
Co-supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - Current EARLY_JAKi: JAK-STAT signaling pathway as key to chronic arthritis onset
Co-supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021 Giant cell arteritis: characterization of a single-centre cohort
Supervisor
Integrated Master In Medicine (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020 - 2021 Clinical Course and Predictors of Severe Coronavirus Disease 19 Among Patients with Rheumatic Diseases
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2021 Consulta Multidisciplinar de Síndrome de Sjögren: caracterização clínica dos primeiros 100 doentes
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2017 Joint counts variability in rheumatoid arthritis patients followed in a real-life setting.
Supervisor
Universidade de Lisboa Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2018 T follicular helper cells and T follicular regulatory cells in systemic lupus erythematosus.
(Thesis) Main arguer
Miguel de Bragança Schön (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2012 - Current Portuguese Society of Rheumatology Member

Committee member

Activity description
Role
Institution / Organization
2020 - Current Member of the EULAR Task Force for Recommendations in Training in Rheumatology
Member
European League Against Rheumatism, Switzerland
2019 - Current Co-Chair of Study Group on Systemic Rheumatic Diseases (GEDRESIS)
Coordinator
Sociedade Portuguesa de Reumatologia, Portugal
2019 - Current Coordinator of the Early Arthritis Clinic
Coordinator
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2017 - Current Junior Disease Coordinator for Sjögren's Syndrome, ERN-ReCONNET
Coordinator
European Reference Networks, Belgium
2017 - Current Member of the EULAR Sjögren's Syndrome Experimental and Translational Investigative Alliance Study Group (eSSential)
Member
European League Against Rheumatism, Switzerland
2015 - Current Coordinator of the Sjögren's Syndrome Clinic
Coordinator
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
2013 - Current Member of the EULAR Synovitis Study Group (ESSG)
Member
European League Against Rheumatism, Switzerland
2012 - Current Member of the Study Group on Rheumatoid Arthritis (GEAR)
Member
Sociedade Portuguesa de Reumatologia, Portugal
2020 - 2022 Member of the EULAR Synovitis Study Group Task Force Group for Synovial Tissue Recommendations
Member
European League Against Rheumatism, Switzerland
2018 - 2019 Member of the EULAR-Sjögren's Syndrome Task Force Group for Treatment Recommendations
Member
European League Against Rheumatism, Switzerland
2014 - 2017 EMEUNET Working Group member
Member
European League Against Rheumatism, Switzerland

Conference scientific committee

Conference name Conference host
2022 - 2022 EULAR 2022 EULAR
2021 - 2021 EULAR 2021 EULAR
2020 - 2020 EULAR 2020 EULAR
2019 - 2019 XXI Congresso Português de Reumatologia Sociedade Portuguesa de Reumatologia
2017 - 2017 EULAR 2017 EULAR
2016 - 2016 EULAR 2016 EULAR
2015 - 2015 EULAR 2015 EULAR

Mentoring / Tutoring

Topic Student name
2020/01 - Current Rheumatology Internship Matilde Bandeira
Distinctions

Award

2020 Honorable Mention for Oral Presentation, XXII Portuguese Congress of Rheumatology
Sociedade Portuguesa de Reumatologia, Portugal
2018 2nd place of the Medical Board award Prof. Jorge Horta
Ordem dos Médicos, Portugal
2018 Honourable Mention for Poster Presentation, XX Portuguese Congress of Rheumatology
Sociedade Portuguesa de Reumatologia, Portugal
2015 2nd Prize for Best Poster in Jornadas CHULN
Centro Hospitalar Universitário Lisboa Norte EPE, Portugal

Other distinction

2017 EULAR Travel Grant 2017
European League Against Rheumatism, Switzerland
2017 Research Bursary SPR 2017 / JAKIE Program
Sociedade Portuguesa de Reumatologia, Portugal
2016 Research Bursary from the Portuguese Society of Rheumatology Research and Training Support Fund 2016
Sociedade Portuguesa de Reumatologia, Portugal
2015 Research Bursary from the Portuguese Society of Rheumatology Research and Training Support Fund 2015
Sociedade Portuguesa de Reumatologia, Portugal
2014 Honourable Mention for Oral Presentation, XVII Congresso Portugue^s de Reumatologia, Albufeira, Portugal, May 2014
2014 EULAR Scientific Training Bursary, 6 months research fellowship, Centre for Experimental Medicine & Rheumatology, Queen Mary University of London
European League Against Rheumatism, Switzerland
2014 Training Bursary from the Portuguese Society of Rheumatology Research and Training Support Fund 2014, for 6 months research fellowship, Centre for Experimental Medicine & Rheumatology, Queen Mary University of London
Sociedade Portuguesa de Reumatologia, Portugal
2014 Interno Doutorando PhD Bursary
Fundação para a Ciência e a Tecnologia, Portugal
2013 Best Poster Award - "Can we safely start biological therapy in rheumatic patients with prior history of active tuberculosis?"
2013 EULAR Travel Grant, 2013 EULAR Epidemiology Course, Berlin, Germany
European League Against Rheumatism, Switzerland
2009 Universidade de Lisboa - Caixa Geral de Depósitos Award
Caixa Geral de Depositos, Portugal
2009 Professor Manuel Machado Macedo Award
Centro de Estudos Professor Manuel Machado Macedo, Portugal
2007 Merit Scholarship
Universidade de Lisboa, Portugal