Identification
Personal identification
- Full name
- Iris Silva
Citation names
- Silva, Iris AL
Author identifiers
- Ciência ID
- 8319-EDFC-1260
- ORCID iD
- 0000-0002-8062-5558
- Google Scholar ID
- Iris A.L. Silva
- Researcher Id
- U-5740-2017
Email addresses
- iasilva@fc.ul.pt (Professional)
- iris.silva@s2aquacolab.pt (Professional)
Websites
- https://www.s2aquacolab.pt/team-2/iris-silva (Professional)
Knowledge fields
- Natural sciences - Biological Sciences - Molecular Biology
- Natural sciences - Biological Sciences - Molecular Biology
- Medical and Health Sciences - Health Sciences
- Natural sciences - Biological Sciences - Marine Biology
- Natural sciences - Biological Sciences - Biochemical Research Methods
- Agrarian Sciences - Agriculture, Forestry and Fisheries - Fishery
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
- Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
- Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
- Medical and Health Sciences - Basic Medicine - Human Genetics
- Natural sciences - Biological Sciences - Microbiology
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese (Mother tongue) | |||||
English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Spanish; Castilian | Intermediate (B1) | Intermediate (B1) | Beginner (A1) | Intermediate (B1) | Beginner (A1) |
French | Beginner (A1) | Intermediate (B1) | Beginner (A1) | Beginner (A1) | Beginner (A1) |
Education
Degree | Classification | |
---|---|---|
2011/01/01 - 2015/12/15
Concluded
|
PhD in Biomedical Sciences (Doutoramento)
Universidade do Algarve, Portugal
"Genetic and Functional Analysis of PDB6 locus in Paget's Disease of Bone" (THESIS/DISSERTATION)
|
Very good unanimously (distinction/honors) |
2009/09 - 2011/10
Concluded
|
Master in Biomedical Sciences (Mestrado integrado)
Universidade do Algarve, Portugal
"Role of Xeroderma pigmentosum group-D (XPD) in gene expression regulation" (THESIS/DISSERTATION)
|
18/20 |
2006/09 - 2009/07
Concluded
|
Graduation in Biomedical Sciences (Licenciatura)
Universidade do Algarve, Portugal
"Detecção do Cancro da mama: Testes de diagnóstico precoce e a sua utilidade" (THESIS/DISSERTATION)
|
16/20 |
Affiliation
Others
Category Host institution |
Employer | |
---|---|---|
2022/02/01 - Current | Assistant researcher in Molecular Biology | S2AQUAcoLAB, Portugal |
S2AQUAcoLAB, Portugal | ||
2017 - 2022/01/31 | Postdoc fellowship in the European project: "HIT-CF: Personalized Treatment For Cystic Fibrosis Patients with Ultra-rare CFTR Mutations" financed by the European Commission (H2020) | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal | ||
2021/11 - 2022/01 | Assistant Professor of Physiology | Universidade de Lisboa Faculdade de Ciências, Portugal |
Universidade de Lisboa Faculdade de Ciências, Portugal | ||
2017/04/20 - 2017/12/31 | Postdoc fellowship in the project: "Characterization of Orphan CFTR Mutations" (FFCUL CC6418) (co- financed by the US CFF - Cystic Fibrosis Foundation) | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
2016/10/20 - 2017/04/20 | Postdoc fellowship in the project "Prediction of the Clinical Efficacy of CFTR Modulator Drugs Using Intestinal Organoids and Nasal Cells from Patients with Cystic Fibrosis", funded by Gilead Sciences | Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal |
2016/01/15 - 2016/08/15 | Postdoc fellowship in functional genomics, genetic regulation and cancer. Study the allelic imbalance in gene expression and how it can contribute to susceptibility to breast cancer. | Universidade do Algarve Centro de Investigação em Biomedicina, Portugal |
2012/01/02 - 2015/12/17 | PhD fellowship to elaborate my PhD thesis entitled " Genetic and functional analysis of the PDB6 locus in Paget's disease of bone". | Centro de Ciências do Mar, Portugal |
2009/09 - 2011/09 | Research fellow to elaborate my Master thesis entitled "Molecular cloning and analysis of xpd expression in zebrafish." | Centro de Ciências do Mar, Portugal |
Centro de Ciências do Mar, Portugal | ||
2009/10/01 - 2010/07/31 | Part of a group in CBME, by own initiative, to get more practical experience in lab work such as mice models genotyping. | Universidade do Algarve Centro de Investigação em Biomedicina, Portugal |
2008/09/01 - 2008/12/01 | Volunteering in the service of Medical Oncology of Hospital de Faro, within the scope of my Bachelor thesis, for patient data assessment . | Hospital de Faro, Portugal |
Projects
Contract
Designation | Funders | |
---|---|---|
2022/10 - Current | Portuguese Blue Biobank
.
Principal investigator
S2AQUAcoLAB, Portugal
|
Governo da República Portuguesa
Ongoing
|
2021/09 - 2022/02 | TestMed - Study of new drugs response and treatment prediction in organoids from individuals with Cystic Fibrosis
BIOSI#0958
Post-doc
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Concluded
|
2018 - 2022 | HIT-CF: Personalised Treatment For Cystic Fibrosis Patients With Ultra-rare CFTR Mutations (and beyond)
FCIENCIAS ID CC 307 (GA number 755021)
Post-doc Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
European Commission
Concluded
|
2018/10/01 - 2021/09/30 | Identificação de Novos Fármacos para Fibrose Quística
PTDC/MED-QUI/28800/2017
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2018/01 - 2021/03 | iDrugCF - Identification of New Drugs for Cystic Fibrosis
-
Researcher
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2017 - 2018 | Characterization of Orphan CFTR Mutations
FFCUL CC6418
Post-doc Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Cystic Fibrosis Foundation
Concluded
|
2016/10 - 2017/04 | Prediction of the Clinical Efficacy of CFTR Modulator Drugs Using Intestinal Organoids and Nasal Cells from Patients with
Cystic Fibrosis
FFCUL CC6362
Post-doc Fellow
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
Gilead Sciences Lda
Concluded
|
2016/03 - 2016/10 | GenCar - Genetic Control of Gene Expression in Cancer Risk
FP7-MC-CIG_303745
Post-doc Fellow
|
Concluded
|
Outputs
Publications
Conference paper |
|
Conference poster |
|
Journal article |
|
Thesis / Dissertation |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2021/11/30 | Oral presentation in national conference - Personalized Medicine for Cystic Fibrosis: Finding Therapies for All Using Patient-Derived 3D Intestinal Organoids | 5ª Conferência Anual da redeSAÚDE 2021
redeSAÚDE (Portugal)
|
2021/11/20 | Oral presentation in national conference - Non eligible mutations for Kaftrio: Future perspectives. | Semana Europeia da Fibrose Quística 2021
Associação Nacional de Fibrose Quística
|
2021/11/12 | Oral presentation in national conference - Cystic Fibrosis: Towards personalized medicine | 37º Congresso Nacional de Pneumologia
Sociedade Portuguesa de Pneumologia (Portugal)
|
2021/11 | Oral presentation in international conference - Characterization of four rare CFTR trafficking mutants and their response to rescue strategies | North American Cystic Fibrosis Conference 2021
Cystic Fibrosis Foundation (United States)
|
2021/06/16 | Oral presentation in national conference - Talks in BioMed | Talks in BioMed
Universidade do Algarve (Portugal)
|
2021/06/10 | Oral presentation in international conference - First results of the HIT-CF ex vivo organoid study show rescue of CFTR with ultra-rare mutations by a novel triple combination of CFTR modulators | 44th European Cystic Fibrosis Conference 2021
European Cystic Fibrosis Society
|
2020/11/26 | Oral presentation in national conference - HIT-CF: Personalised Treatment for Cystic Fibrosis Patients | BioISI day
BioISI - Biosystems & integrative sciences institute (Portugal)
|
2020/11/21 | Oral presentation in international conference - To where we are heading: the era of high technology for the treatment of Cystic Fibrosis | 1st Interdisciplinary Brazilian Simposium on Cystic Fibrosis
Unidos pela Vida (Brazil)
|
2019/11/30 | Oral presentation in national conference - "Alta reprodutibilidade do ensaio de inchamento induzido por forscolina entre três laboratórios europeus". | Jornadas Nacionais de Fibrose Quística 2019
Sociedade Portuguesa de Fibrose Quística (Aveiro, Portugal)
|
2019/11/30 | Oral presentation in national conference - Medicina Personalizada na Fibrose Quística: Caracterização Funcional e Teratipagem de Mutações Raras | Jornadas Nacionais de Fibrose Quistica
Sociedade Portuguesa de Fibrose Quistica (Aveiro, Portugal)
|
2019/10/31 | Oral presentation in international conference - Partial Epithelial to Mesenchymal Transition (EMT) in CF: CF as an Epithelial Differentiation Disorder | 33rd North American Cystic Fibrosis Conference 2019
Cystic Fibrosis Foundation (Nashville, United States)
|
2019/10/31 | Oral presentation in international conference - "High reproducibility of forskolin-induced swelling of intestinal organoids across three academic laboratories" | North American Cystic Fibrosis Conference
Cystic Fibrosis Foundation (Nashville, United States)
|
2019/09/12 | Oral presentation in international meeting - "Organoids for CF diagnosis: Correlations with rectal biopsies" | 3rd REAP ECFS Meeting - Biomarkers
European Cystic Fibrosis Society (Lisboa, Portugal)
|
2019/05/06 | Oral presentation in international conference - Electrophysiological Measurements in Rectal Biopsies: a Better Prognosis Biomarker for CF Disease? | 42nd European Cystic Fibrosis Conference
European Cystic Fibrosis Society (Liverpool, United Kingdom)
|
2019/03/27 | Oral presentation in international conference - Characterization of the Rare S955P-CFTR Mutation and its Response to Modulators in Cellular Models and Patient-Derived Materials | 16th ECFS Basic Science Conference 2019
European Cystic Fibrosis Society (Dubrovnik, Croatia)
|
2018/06/06 | Oral presentation in international conference by invitation - From the bench to bedside: expanding CFTR modulators to rare mutations by response assessment in patients-derived materials and cellular models | 41st European Cystic Fibrosis Conference 2018
European Cystic Fibrosis Society (Belgrade, Serbia)
|
2018/04/21 | Oral presentation in national conference by invitation - Medicina personalizada na Fibrose Quística - Caracterização funcional de mutações raras na CFTR e resposta a moduladores em amostras de doentes e modelos celulares | Jornadas Nacionais de Ciências Biomédicas 2018
Curso de Ciências Biomédicas da UAlg (Faro, Portugal)
|
2018/02/17 | Oral presentation in international conference - "Organoides Intestinais" | Workshop Fibrose Cística 2018
Unicamp (Campinas, Brazil)
|
2017/11/18 | Oral presentation in national conference - "Previsão de respostas aos novos fármacos em materiais de pacientes" | Jornadas Nacionais Fibrose Quística 2017
Vertex (Fátima, Portugal)
|
2014/11/24 | Oral presentation in national meeting - "Functional study of Optineurin variants associated with Paget’s disease of bone." | Post-ASBMR Meeting
Centre Hospitalier Universitaire de Laval (Quebec, Canada)
|
2013/04/18 | Oral presentation in international conference - "Genetic variation in PDB6 locus and Paget’s Disease of Bone" | 47th Annual Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2019/01/03 - Current | Personalised Therapies for all: Restoring airway function in CF using Alternative Chloride Channels
Co-supervisor of Violeta Railean
|
Biochemistry (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
2020/01/01 - 2021/12/31 | Identification of Portuguese patients with Cystic Fibrosis by Complete CFTR Gene Mutation Genotyping and Rectal Biopsy Analyses
Co-supervisor of Cláudia Rodrigues
|
Universidade de Lisboa Faculdade de Ciências, Portugal
|
2018/09 - 2019/12 | Epithelial Differentiation: From Organoids to Cells in Cystic Fibrosis Patients
Co-supervisor of André Gomes
|
Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
2018/09/01 - 2019/09/01 | Research PhD fellowship - HIT-CF Personalised Treatment for Cystic Fibrosis patients with ultra-rare CFTR Mutations (and beyond)
Co-supervisor of Ricardo Vieira
|
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
2017/09 - 2018/10 | Diagnosis, Prognosis and Personalized Treatment of Cystic Fibrosis
Co-supervisor of Raquel Centeio
|
Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
2017/09/01 - 2018/08/01 | Research fellowship - HIT-CF Personalised Treatment for Cystic Fibrosis patients with ultra-rare CFTR Mutations (and beyond)
Co-supervisor of Rita Marques
|
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
2018/04 - 2018/08 | Study of ultra-rare mutations in CFTR using patient derived samples
Supervisor
|
Licenciatura em Bioquímica (Scientific initiation)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
|
2015 - 2015 | Paget’s disease of bone
Co-supervisor of Sara Teixeira
|
Medicine (Other)
Universidade do Algarve, Portugal
|
2015 - 2015 | Study of the regulation of the bidirectional promoter shared by OPTN and CCDC3, via NFkB
Co-supervisor of Patricia Alves
|
Biochemistry (Degree)
Universidade do Algarve, Portugal
|
2015 - 2015 | Osteosarcoma in Paget’s disease of bone
Co-supervisor of Teresa Lourenço
|
Biomedical Sciences (Degree)
Universidade do Algarve, Portugal
|
2015 - 2015 | Study of the regulation of the bidirectional promoter shared by OPTN and CCDC3, via NFkB
Co-supervisor of Ricardo Matos
|
Biomedical Sciences (Degree)
Universidade do Algarve, Portugal
|
2015 - 2015 | Contribution of PDB6 locus to Paget’s disease of bone
Co-supervisor of David Marques
|
Medicine
Universidade do Algarve, Portugal
|
2014 - 2014 | Study of the putative effect of rs3829923 in OPTN gene on the predisposition to Paget’s disease of bone
Co-supervisor of Ana André
|
Biomedical Sciences (Degree)
Universidade do Algarve, Portugal
|
2014 - 2014 | Study of characteristics and activity of the bidirectional promoter shared by two genes: OPTN and CCDC3
Co-supervisor of Inês Perrolas
|
Biomedical Sciences (Degree)
Universidade do Algarve, Portugal
|
2013 - 2013 | Study of the putative effect of RV-9906 in OPTN gene on the predisposition to Paget’s disease of bone
Co-supervisor of Biomedical Sciences
|
Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2016/07/01 - 2016/07/02 | Organization of the first annual scientific meeting organized by CBMR (2015/07/01)
Congress (Co-organisor)
|
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal |
2015/02 - 2015/02 | OPEN DAY - Organization of the activity ‘From the crime scene to the lab’ in the scope of the Open Day of the University of
Algarve. Press release: http://www.sulinformacao.pt/2015/02/fotogaleria-ualg-teve-mais-um-dia-aberto-onde-ate-se-resolveram-crimes/ (2015/02)
Other (Other)
|
Universidade do Algarve, Portugal |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2019/11/08 | Transcriptional regulation of the overlapping human genes OPTN and CCDC3
(Thesis) Main arguer
|
Michele Loiodice (Master)
Universidade do Algarve, Portugal
|
Association member
Society Organization name | Role | |
---|---|---|
2014/03/14 - Current | Founder of Associação Nacional de Ciências Biomédicas (ANCiB) | Founder |
Committee member
Activity description Role |
Institution / Organization | |
---|---|---|
2017 - 2022 | Member of the European Cystic Fibrosis Society (ECFS)
Member
|
European Cystic Fibrosis Society, Denmark |
2014 - 2016 | Member of the American Society of Bone and Mineral Research
Member
|
American Society of Bone and Mineral Research, United States |
2012 - 2016 | Member of the European Calcified Tissue Society (ECTS)
Member
|
European Calcified Tissue Society, United Kingdom |
2013 - 2015 | Biomedical Sciences Doctorate Pedagogic Committee President
President / Vice-president
|
Universidade do Algarve, Portugal |
2012 - 2013 | Biomedical Sciences Doctorate Pedagogic Committee Vice President
President / Vice-president
|
Universidade do Algarve, Portugal |
2009 - 2010 | Biomedical Sciences Master Pedagogic Committee Vice President
President / Vice-president
|
Universidade do Algarve, Portugal |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2018/04/30 - Current | Seminar in Cell Culture Techniques - "Medicina personalizada na Fibrose Quística - Caracterização funcional de mutações raras na CFTR e resposta a moduladores em amostras de doentes e modelos celulares" | Ciências Biomédicas (Licenciatura) | Universidade do Algarve, Portugal |
2016/04/27 - Current | Seminar in Human Genetics - "Paget’s Disease of Bone" | Molecular and Microbiotic Biology (Mestrado) | Universidade do Algarve, Portugal |
2015/05/27 - Current | Seminar in Molecular Genetics - "TFIIH: Da Genética para a Clínica" | Ciências Biomédicas/ Ciências Farmacêuticas/ Biologia/ Biologia Marinha (Licenciatura) | Universidade do Algarve, Portugal |
2014/04/08 - Current | Seminar in Molecular Genetics - "TFIIH: Da Genética para a Clínica" | Ciências Biomédicas | Universidade do Algarve, Portugal |
2014/01/29 - Current | Seminar in Bone and Cartilage biology - "Análise genética do locus PDB6 na Doença Óssea de Paget" | Ciências Biomédicas | Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal |
2013/12/10 - Current | Seminar in Human Genetics - "Doença Óssea de Paget" | Ciências Biomédicas | Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal |
2020/04/09 - 2020/04/09 | Seminar in Cell Culture Techniques - "Medicina personalizada na Fibrose Quística - Caracterização funcional de mutações raras na CFTR e resposta a moduladores em amostras de doentes e modelos celulares" | Ciências Biomédicas (Licenciatura) | Universidade do Algarve, Portugal |
2014/02 - 2014/04 | Lecturing practical classes of Technology of animal cell culture to students of the Biomedical Sciences degree | Ciências Biomédicas (Licenciatura) | Universidade do Algarve, Portugal |
2013/02 - 2013/03 | Lecturing practical classes of Technology of animal cell culture to students of the Biomedical Sciences degree | Ciências Biomédicas (Licenciatura) | Universidade do Algarve, Portugal |
Distinctions
Award
2023 | Alumni Career Award
Universidade do Algarve, Portugal
|
2022 | Outstanding Professional Achievement Award
Rotary Club Tavira, Portugal
|
2021 | Best Young Investigator - 43rd European Cystic Fibrosis Society Conference
European Cystic Fibrosis Society, Denmark
|
2019 | Cystic Fibrosis Research Bursaries - 42nd European Cystic Fibrosis Society Conference
Chiesi Limited UK, United Kingdom
|
2018 | Student Helper Award - 15th Basic Science Conference
European Cystic Fibrosis Society, Denmark
|
2018 | Best Young Investigator - 41st European Cystic Fibrosis Society Conference
European Cystic Fibrosis Society, Denmark
|
Other distinction
2023 | Voto Congratulação
Câmara Municipal de Tavira, Portugal
|
2011 | Merit Scholarship
Universidade do Algarve, Portugal
|
2010 | Merit Scholarship
Universidade do Algarve, Portugal
|