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Patrícia Sofia Menalha Amado graduated from the University of Algarve's Faculty of Science and Technology with a Master in Pharmaceutical Sciences (MICF) in 2015. She is currently a researcher at Algarve Centre of Marine Sciences (CCMAR), and she is finishing her PhD degree in Chemistry (specialty in Organic Chemistry), under the supervision of Prof. Maria de Lurdes Cristiano (University of Algarve) and Prof. Paul O'Neill (University of Liverpool). She has 10 peer-reviewed publications in journals such as the Journal of Organic Chemistry, ACS Omega, Journal of Physical Chemistry Letters, Medicinal Research Reviews, Molecules, ChemPlusChem, and The Journal of Physical Chemistry A. She participated in 10 international (3 poster presentations) and 5 national (3 oral and 4 poster presentations) conferences/symposiums/seminars/summer schools. She also co-supervised one project for the course of Biochemistry. In 2021, she received a prize (as first classified in the R&D category) in the contest "Ideias em Caixa 2020", along with two colleagues (Dr. Joana Leal and Prof. Maria Lurdes Cristiano). She also won the best poster prize at Conference ESOR2021, in September 2021. During her course at MICF, she received three awards as the year's best student. Her main fields are Synthetic and Organic Chemistry, with an emphasis on Medicinal Chemistry, her research interests include the development of novel catalysts for the synthesis of cyclic endoperoxides, the discovery of novel molecules for drug design, focusing on human infectious diseases such as Leishmaniasis and Tuberculosis, and the aquaculture parasitic disease Amyloodiniosis. Her laboratory skills involve detailed planning of new routes of organic reactions to synthesize novel compounds, from setting reactions up to their follow-up, followed by the procedures required for isolation and complete characterization of the nature and purity of synthesized products (1D/2D NMR, MS, IR). Computer skills: Microsoft Office (advanced in Word, Excel, and PowerPoint); IBM SPSS Statistics, ChemDraw, MestreNova, StarDrop, PyMol, GOLD suite, Spartan, Weka. Programming Languages: R and Python. Personal skills: resilient, responsible, proactive, and teamwork. Keywords: 1,2,4,5-tetraoxanes, 1,2,4-trioxanes, malaria, leishmaniasis, amyloodiniosis, tuberculosis.
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Identification

Personal identification

Full name
Patrícia Sofia Menalha Amado

Citation names

  • Amado, Patrícia S. M.

Author identifiers

Ciência ID
8617-A360-B70A
ORCID iD
0000-0002-7307-9210
Scopus Author Id
57214102194

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Chinese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2022/07/03 - 2022/09/08
Concluded
 High-throughput and Ensemble-based Screening for Drug Discovery Workshop - 8 weeks (online) (Outros)
Bioinformatics Workshop Fiesta 2020/22, Singapore
2018/01/02 - 2022/02/28
Ongoing
 Chemistry (Doutoramento)
Major in Organic Chemistry
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"PhD-Working programme: A Chemical Proteomics Approach to Defining the Mechanism of Artemisinin Action and Resistance in PfK13 Resistant parasites" (THESIS/DISSERTATION)
2021/12/08 - 2021/12/11
Concluded
 4 Day Online Workshop on Introduction to Artificial Intelligence in Drug Discovery (Outros)
BDG Lifesciences, India
2021/12/04 - 2021/12/07
Concluded
 4 Day Online Workshop in Machine Learning in Chemoinformatics & Drug Discovery (Outros)
BDG Lifesciences, India
2021/03/01 - 2021/07/12
Concluded
 Python - Intermediate (Outros)
CINEL - Centro de Formação Profissional da Indústria Electrónica, Energia, Telecomunicações e Tecnologias da Informação, Portugal
 16
2021/04 - 2021/04
Concluded
 Smarter experimentation for scientists and engineers: online training programme on design of experiments (Outros)
JMP Group Inc, United States
2020/11/01 - 2021/02/23
Concluded
 Python - Beginner (Outros)
CINEL - Centro de Formação Profissional da Indústria Electrónica, Energia, Telecomunicações e Tecnologias da Informação, Portugal
 19
2019/10 - 2019/12
Concluded
 Advanced Spectroscopic Elucidation for Organic Chemists (Outros)
University of Liverpool Department of Chemistry, United Kingdom
 18
2015
Concluded
 Integrated Master in Pharmaceutical Sciences (MICF) (Mestrado integrado)
Major in https://sapientia.ualg.pt/handle/10400.1/8128
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Metodologias de síntese de tetraoxanos com potencial utilização em química medicinal " (THESIS/DISSERTATION)
 17.21
Affiliation

Others

Category
Host institution 		Employer
2022/05/01 - Current Researcher. Project: MAR-01.03.01-FEAMP-0049 - DEPURATOX - Decontamination of bivalve molluscs, contaminated with marine biotoxins, during the purification process. Centro de Ciências do Mar, Portugal
2018/01/02 - Current PhD Student in Chemistry. Thesis: "PhD-Working programme: A Chemical Proteomics Approach to Defining the Mechanism of Artemisinin Action and Resistance in PfK13 Resistant parasites" Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
University of Liverpool Department of Chemistry, United Kingdom
2016/03/29 - 2017/12/12 Technical Director Pharmacist Farmácia Brito, Portugal
2015/11/09 - 2016/03/28 Pharmacist Farmácia Brito, Portugal
2015/03/30 - 2015/08/28 Intern Pharmacist Farmácia Pacheco, Portugal
2015/03/02 - 2015/03/27 Intern. Learning the standards of good laboratory practices, quality control, chromatography techniques (HPLC, GC), production at an industrial level. Sofarimex - Indústria Química e Farmacêutica, S.A., Portugal
2014/09/15 - 2015/02/28 Research Volunteer. Development and synthesis of new tetraoxanes with antileishmania activity Centro de Ciências do Mar, Portugal
2014/06/30 - 2014/08/01 Exchange Student. Development and synthesis of new compounds with inhibitor capacity for the HIV integrase University of Sunderland, United Kingdom
2013/03/04 - 2013/06/28 Research Volunteer. Development and synthesis of new quinolones with antimalaric activity Centro de Ciências do Mar, Portugal
Projects

Grant

Designation Funders
2018/01/02 - 2021/12/31 Chemical Proteomics Approach to Defining the Mechanism ofArtemisinin Action and Resistance in PfK13 Resistance
SFRH/BD/130407/2017
PhD Student Fellow
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

University of Liverpool Department of Chemistry, United Kingdom
Ongoing
Outputs

Publications

Book chapter
  1. Amado, Patrícia S. M.; Luís Frija; O'Neill, Paul M.; Cristiano, Maria Lurdes Santos. "Synthesis of non-symmetrical 1,2,4,5-tetraoxanes: Past and current routes". In Synthesis and Applications in Chemistry and Materials. World Scientific, 2023.
    Under revision
Conference poster
  1. Amado, Patrícia S. M.. "Comparison of Structural and Energetic Properties Between Trioxolane and Tetraoxane Analogues with Established Antiparasitic Activity". Paper presented in 8th EuChemS Chemistry Congress, 2022.
  2. Amado, Patrícia. "An Endoperoxide-Based Hybrid Approach against Mycobacterium tuberculosis". Paper presented in Encontro Anual de Doutorandos Da Universidade do Algarve, 2021.
  3. Amado, Patrícia; Luís M. T. Frija; Jaime A. S. Coelho; Paul O'Neill; Cristiano, Maria Lurdes Santos. "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid". Paper presented in 18th European Symposium on Organic Reactivity (ESOR2021), 2021.
  4. Amado, Patrícia; Luís Frija; Jaime A. S. Coelho; Paul O'Neill; Professsora Doutora Maria de Lurdes Cristiano. "A facile, efficient, and reusable silica sulfuric acid (ssa) catalysed synthesis of non-symmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes". Paper presented in 7PYCHEM (7th Portuguese Young Chemists Meeting), 2021.
  5. Amado, Patrícia; Elisa M. Brás; José A. Paixão; Rui Fausto; Maria L. S. Cristiano. "Unraveling the structure of peroxides with antiparasitic activity; relative impact of a trioxolane or a tetraoxane pharmacophore on the overall molecular structure". Paper presented in First National Crystallographic Meeting, 2019.
  6. Amado, Patrícia; Lília I. L. Cabral; Sébastien Pomel; Sandrine Cojean; Philippe M. Loiseau; Maria L. S. Cristiano. "Synthesis and in vitro antileishmanial activity of selected tetraoxanes against Leishmania donovani". Paper presented in 6th portuguese young chemists meeting, 2018.
    10.3390/molecules25030465
Journal article
  1. Patrícia S. M. Amado; Christopher Woodley; Maria L. S. Cristiano; Paul M. O’Neill. "Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis: Computational Analysis of Physicochemical and ADMET Properties". ACS Omega (2022): https://doi.org/10.1021/acsomega.2c05307.
    10.1021/acsomega.2c05307
  2. Patrícia S. M. Amado; Inês C. C. Costa; José A. Paixão; Ricardo F. Mendes; Sofia Cortes; Maria L. S. Cristiano. "Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids". Molecules (2022): https://doi.org/10.3390/molecules27175401.
    10.3390/molecules27175401
  3. Patricia Sofia Menalha Amado. "Unravelling the Structure of Peroxides with Antiparasitic Activity: The Relative Impact of a Trioxolane or a Tetraoxane Pharmacophore on the Overall Molecular Structure". ChemPlusChem (2022): http://dx.doi.org/10.1002/cplu.202200207.
    10.1002/cplu.202200207
  4. Andreia Mendes; Ana Armada; Lília I. L. Cabral; Patricia Sofia Menalha Amado; Lenea Campino; Maria Lurdes Santos Cristiano; Cortes S.. "1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/4/446.
    10.3390/ph15040446
  5. Woodley, Christopher M.; Amado, Patrícia S. M.; Cristiano, Maria L. S.; O'Neill, Paul M.. "Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies". Medicinal Research Reviews (2021): http://dx.doi.org/10.1002/med.21849.
    10.1002/med.21849
  6. Amado, Patrícia S. M.; Frija, Luís M. T.; Coelho, Jaime A. S.; O’Neill, Paul M.; Cristiano, Maria L. S.. "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid". The Journal of Organic Chemistry 86 15 (2021): 10608-10620. http://dx.doi.org/10.1021/acs.joc.1c01258.
    Published • 10.1021/acs.joc.1c01258
  7. Joana F. Leal; Bruno Guerreiro; Patrícia S. M. Amado; André L. Fernandes; Luísa Barreira; José A. Paixão; Maria L. S. Cristiano. "On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate". Molecules 26 6 (2021): 1501-1501. https://doi.org/10.3390/molecules26061501.
    10.3390/molecules26061501
  8. Nunes, Cláudio M.; Pereira, Nelson A. M.; Reva, Igor; Amado, Patrícia S. M.; Cristiano, Maria L. S.; Fausto, Rui. "Bond-Breaking/Bond-Forming Reactions by Vibrational Excitation: Infrared-Induced Bidirectional Tautomerization of Matrix-Isolated Thiotropolone". The Journal of Physical Chemistry Letters 11 19 (2020): 8034-8039. http://dx.doi.org/10.1021/acs.jpclett.0c02272.
    10.1021/acs.jpclett.0c02272
  9. Brás, Elisa M.; Cabral, Lília I. L.; Amado, Patrícia S. M.; Abe, Manabu; Fausto, Rui; Cristiano, Maria L. S.. "Photoinduced Reactivity in a Dispiro-1,2,4-trioxolane: Adamantane Ring Expansion and First Direct Observation of the Long-Lived Triplet Diradical Intermediates". The Journal of Physical Chemistry A 124 21 (2020): 4202-4210. http://dx.doi.org/10.1021/acs.jpca.0c01974.
    10.1021/acs.jpca.0c01974
  10. Lília I. L. Cabral; Sébastien Pomel; Sandrine Cojean; Patrícia S. M. Amado; Philippe M. Loiseau; Maria L. S. Cristiano. "Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani". Molecules 25 3 (2020): 465-465. https://doi.org/10.3390/molecules25030465.
    10.3390/molecules25030465
Thesis / Dissertation
  1. Amado, Patrícia. "Metodologias de síntese de tetraoxanos com potencial utilização em química medicinal". Master, Universidade do Algarve, 2015. https://sapientia.ualg.pt/handle/10400.1/8128.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/04/22 An Endoperoxide Based Hybrid Approach against Mycobacterium tuberculosis 14th National Organic Chemistry Meeting (14ENQO) and 7th National Medicinal Chemistry Meeting (7ENQT)
Portuguese Chemical Society (SPQ) (Lisbon, Portugal)
2021/10/29 An Endoperoxide-Based Hybrid Approach against Mycobacterium tuberculosis Encontro Anual de Doutorandos Da Universidade do Algarve
(Loulé)
2020/11/19 Finalist at "1st NATIONAL RETROSYNTHESIS COMPETITION 2020" Oral presentation done at the 7th Portuguese Young Chemists Meeting, between May 19th to 21st - 2021
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/11 - 2021/09 Synthesis of endoperoxide-pyrazole hybrids with potential activity against Leishmania donovani
Co-supervisor
 Bioquímica (Degree)
Universidade do Algarve, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/08/28 - 2022/09/01 8th EuChemS Chemistry Congress - Lisbon
Congress
EuChemS, Belgium

Sociedade Portuguesa de Química, Portugal
2022/04/20 - 2022/04/22 14th National Organic Chemistry Meeting (14ENQO) and 7th National Medicinal Chemistry Meeting (7ENQT)
Meeting
2021/10/12 - 2021/10/13 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics
Conference
 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics
LD Organisation - Scientific Conference Producers, Belgium
2021/09/21 - 2021/09/23 18th European Symposium on Organic Reactivity (ESOR2021)
Symposium
 18th European Symposium on Organic Reactivity (ESOR2021)
2021/09/13 - 2021/09/17 EUROPIN Summer School on Drug: The summer school especially focuses on students and professionals who have a clear interest in learning the basics as well as latest developments in Pharmacoinformatics. The program provides an overview on main approaches and techniques used in computational drug design, ranging from protein modeling, docking, pharmacophore based screening, up to machine learning, data science, and workflows.
Seminar
 EUROPIN Summer School on Drug Design
2021/08/29 - 2021/09/02 XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021)
Symposium
 XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021)
LD Organisation - Scientific Conference Producers, Belgium
2021/05/19 - 2021/05/21 Conference 7th portuguese young chemists meeting
Meeting
 Conference 7th portuguese young chemists meeting
Sociedade Portuguesa de Química, Portugal
2021/05/04 - 2021/05/06 Launching Drug Discovery from Huge Chemical Space
Symposium
 Online Symposium on Novel Computational Approaches for Hit Generation.
LD Organisation - Scientific Conference Producers, Belgium
2019/11/05 - 2019/11/06 Conference Drug Discovery 2019: Looking Back To The Future, Liverpool, UK
Conference
 https://elrig.org/portfolio/2019-drug-discovery/
2019/03/18 - 2019/03/20 Participation on "From Molecure to Medicine" Training School
Other
 https://epichembio.eu/training-school-from-molecule-to-medicine-ljubljana/
Univerza v Ljubljani Fakulteta za farmacijo, Slovenia
2018/07/01 - 2018/07/06 Conference ICPOC - 24th International Conference on Physical Organic Chemistry
Congress
 https://icpoc24.ualg.pt/
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018/05/15 - 2018/05/18 Conference 6th portuguese young chemists meeting
Conference
 http://6pychem.eventos.chemistry.pt/
Distinctions

Award

2021 Poster Prize Winner: "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid"
2021 1st classified in the R&D category, in the contest "Ideias em Caixa"
Universidade do Algarve, Portugal

Caixa Geral de Depositos, Portugal

Comissão de Coordenação e Desenvolvimento Regional do Algarve, Portugal
2016 Winner of Prize: "Prémio Sociedade Farmacêutica Lusitana"
Ordem dos Farmaceuticos, Portugal

Other distinction

2018 PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2013 Award: "ALUNO DE EXCELÊNCIA FCT 2013, categoria II"
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2012 Award: "ALUNO DE EXCELÊNCIA FCT 2012, categoria I"
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal