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Identification

Personal identification

Full name
Rui Brito

Citation names

  • Brito, Rui
  • Rui M M Brito

Author identifiers

Ciência ID
8E19-C3BB-2B00
ORCID iD
0000-0001-9128-2557

Addresses

  • Departamento de Quimica, Universidade de Coimbra. Rua Larga, 3004-535, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
Education
Degree Classification
1992
Concluded
 PhD in Biochemistry (Doctor of Philosophy)
Rice University, United States
"Type II Dihydrofolate Reductases: Probing the Natural Diversity of Enzyme Active Sites" (THESIS/DISSERTATION)
Projects

Contract

Designation Funders
2018/08/01 - 2021/07/31 Novos antivirais contra Influenza: validação do alvo NS1 e descoberta de compostos líder
PTDC/QUI-OUT/32572/2017
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2019/12/31 Ao Encontro das Regras para a Permeação Passiva através da Barreira Hemato-Encefálica
PTDC/DTP-FTO/2784/2014
Universidade de Coimbra, Portugal

Universidade de Évora, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2015/12/31 Do espaço químico à função biológica: uma viagem pela mão da UC-NMR
RECI/QEQ-QFI/0168/2012
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2015/08/31 Fibrilas Interrompidas: Inibição de interacções aberrantes proteína-proteína em Amilóides
PTDC/QUI-QUI/122900/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/12/31 Procura de regras de alto nível em dobragem e desdobragem de proteínas: das doenças amiloidogénicas à previsão da estrutura proteica
PTDC/BIA-PRO/72838/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 AspectGrid: Aspectos Grid para Aplicações Científicas
GRID/GRI/81880/2006
Universidade do Minho Centro ALGORITMI, Portugal

Universidade do Minho, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Estudo de processos de bioluminescência
PTDC/FIS/73578/2006
Universidade de Coimbra Centro de Física Computacional, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/06/01 - 2010/12/31 P-found: computação GRID e armazenamento distribuído de dados de simulações de dobragem e desdobragem de proteínas
GRID/GRI/81809/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Max Pereira; Vítor Santos Costa; Rui Camacho; Nuno A. Fonseca; Carlos Simões; Rui M. M. Brito. Comparative study of classification algorithms using molecular descriptors in toxicological databases. 2009.
    10.1007/978-3-642-03223-3_11
  2. Rui Camacho; Alexessander Alves; Cândida G. Silva; Rui M. M. Brito. On mining protein unfolding simulation data with inductive logic programming. 2008.
    10.1007/978-3-540-85861-4_21
Conference paper
  1. Vaz, Daniela C.; Brito, Rui M. M.; Mata, Ana I.; Alves, Nuno G.; Simões, Carlos J. V.; Vaz, João Pereira; Duque, Vitor. "Use of molecular interaction fields to understand drug resistance in HIV 1 protease caused by single point mutations". 2018.
    10.4172/0974-276X-C3-119
  2. Silvério, Rita; Rocha, Miguel; Simões, Carlos J. V.; Brito, Rui M. M.; Couto, Bráulio R. G. M.; Santos, Marcos A. dos. "Prediction of drug targets in human pathogens". 2015.
  3. Silva, Cândida G.; Brito, Rui. "A Machine Learning Approach to Enhance Scoring Performance in Docking-Based Virtual Screening Experiments: COX-1 as a Case Study". Paper presented in IWBBIO 2014, 2014.
    Published
  4. Azevedo, Paulo J.; Ferreira, Pedro Gabriel; Silva, Cândida G.; Brito, Rui M. M.. "Spatial clustering of molecular dynamics trajectories in protein unfolding simulations". 2009.
    10.1007/978-3-642-02504-4_14
  5. Azevedo, Paulo J.; Ferreira, Pedro Gabriel; Silva, Cândida G.; Brito, Rui M. M.. "Mining approximate motifs in time series". 2006.
Journal article
  1. Almeida, Zaida L.; Vaz, Daniela C.; Brito, Rui M. M.. "Transthyretin mutagenesis: impact on amyloidogenesis and disease". Critical Reviews in Clinical Laboratory Sciences (2024): 1-25. http://dx.doi.org/10.1080/10408363.2024.2350379.
    Published • 10.1080/10408363.2024.2350379
  2. Amado, Daniela; Chaves, Otávio A.; Cruz, Pedro F.; Loureiro, Rui J. S.; Almeida, Zaida L.; Jesus, Catarina S. H.; Serpa, Carlos; Brito, Rui M. M.. "Folding Kinetics and Volume Variation of the ß-Hairpin Peptide Chignolin upon Ultrafast pH-Jumps". The Journal of Physical Chemistry B 128 20 (2024): 4898-4910. http://dx.doi.org/10.1021/acs.jpcb.3c08271.
    Published • 10.1021/acs.jpcb.3c08271
  3. Sebastião, Fernando; Vaz, Daniela C; Pires, Cristiana L; Cruz, Pedro F; Moreno, Maria João; Brito, Rui M M; Cotrim, Luis; et al. "Nutrient-efficient catfish-based aquaponics for producing lamb's lettuce at two light intensities". Journal of the Science of Food and Agriculture 104 11 (2024): 6541-6552. http://dx.doi.org/10.1002/jsfa.13478.
    Published • 10.1002/jsfa.13478
  4. Iris Correia; Madalena Antunes; Carla Tecelão; Marta Maria de Melo Lopes Neves; Cristiana L. Pires; Pedro Cruz; Maria Rodrigues; et al. "Nutritive Value and Bioactivities of a Halophyte Edible Plant: Crithmum maritimum L. (Sea Fennel)". Plants (2024): https://www.mdpi.com/2223-7747/13/3/427.
    10.3390/plants13030427
  5. Vaz, Daniela C.; Rodrigues, J. Rui; Loureiro-Ferreira, Nuno; Müller, Thomas D.; Sebald, Walter; Redfield, Christina; Brito, Rui M. M.. "Lessons on protein structure from interleukin-4: All disulfides are not created equal". Proteins: Structure, Function, and Bioinformatics 92 2 (2023): 219-235. http://dx.doi.org/10.1002/prot.26611.
    Open access • Published • 10.1002/prot.26611
  6. Mata, Ana I.; Pereira, Nelson A.M.; Cardoso, Ana L.; Nascimento, Bruno F.O.; Pineiro, Marta; Schaberle, Fábio A.; Gomes-da-Silva, Lígia C.; Brito, Rui M.M.; Pinho e Melo, Teresa M.V.D.. "Novel Foscan®-derived ring-fused chlorins for photodynamic therapy of cancer". Bioorganic & Medicinal Chemistry 93 (2023): 117443. http://dx.doi.org/10.1016/j.bmc.2023.117443.
    Open access • Published • 10.1016/j.bmc.2023.117443
  7. Saman Khalighi; Judy Jalkh; Pedro F. Cruz; Rui M. M. Brito; Jaime B. Santos; Abel G. M. Ferreira. "Influence of Pressure and Temperature in the Speed of Sound of Isobutanol + Biodiesel Mixtures". Journal of Chemical & Engineering Data (2023): https://doi.org/10.1021/acs.jced.3c00217.
    10.1021/acs.jced.3c00217
  8. Otávio A. Chaves; Rui J. S. Loureiro; Andreia Costa-Tuna; Zaida L. Almeida; João Pina; Rui M. M. Brito; Carlos Serpa. "Interaction of Two Commercial Azobenzene Food Dyes, Amaranth and New Coccine, with Human Serum Albumin: Biophysical Characterization". ACS Food Science & Technology (2023): https://doi.org/10.1021/acsfoodscitech.3c00125.
    10.1021/acsfoodscitech.3c00125
  9. Andreia E. S. Cunha; Rui J. S. Loureiro; Carlos J. V. Simões; Rui M. M. Brito. "Unveiling New Druggable Pockets in Influenza Non-Structural Protein 1: NS1–Host Interactions as Antiviral Targets for Flu". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032977.
    10.3390/ijms24032977
  10. Zaida L. Almeida; Rui M. M. Brito. "Amyloid Disassembly: What Can We Learn from Chaperones?". Biomedicines (2022): https://doi.org/10.3390/biomedicines10123276.
    10.3390/biomedicines10123276
  11. Abel G. M. Ferreira; Jaime B. Santos; Judy Jalkh; Saman Khalighi; Pedro F. Cruz; Rui M. M. Brito. "Pressure Effect on the Speed of Sound of Waste Cooking Oil Biodiesel". Journal of Chemical & Engineering Data (2022): https://doi.org/10.1021/acs.jced.2c00473.
    10.1021/acs.jced.2c00473
  12. Primitivo, Maria João; Neves, Marta; Pires, Cristiana L.; Cruz, Pedro F.; Brito, Catarina; Rodrigues, Ana C.; de Carvalho, Carla C.C.R.; et al. "Edible flowers of Helichrysum italicum: Composition, nutritive value, and bioactivities". Food Research International 157 (2022): 111399. http://dx.doi.org/10.1016/j.foodres.2022.111399.
    Open access • Published • 10.1016/j.foodres.2022.111399
  13. Abbasi, Maryam; Santos, Beatriz P.; Pereira, Tiago C.; Sofia, Raul; Monteiro, Nelson R. C.; Simões, Carlos J. V.; Brito, Rui M. M.; et al. "Designing optimized drug candidates with Generative Adversarial Network". Journal of Cheminformatics 14 1 (2022): http://dx.doi.org/10.1186/s13321-022-00623-6.
    Open access • Published • 10.1186/s13321-022-00623-6
  14. María Conde-Giménez; Juan José Galano-Frutos; María Galiana-Cameo; Alejandro Mahía; Bruno L. Victor; Sandra Salillas; Adrián Velázquez-Campoy; et al. "Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase". International Journal of Molecular Sciences 23 9 (2022): 4502-4502. https://doi.org/10.3390/ijms23094502.
    10.3390/ijms23094502
  15. João P. Luís; Ana I. Mata; Carlos J. V. Simões; Rui M. M. Brito. "Conformational Dynamics of the Soluble and Membrane-Bound Forms of Interleukin-1 Receptor Type-1: Insights into Linker Flexibility and Domain Orientation". International Journal of Molecular Sciences 23 5 (2022): 2599-2599. https://doi.org/10.3390/ijms23052599.
    10.3390/ijms23052599
  16. João P. Luís; Carlos J. V. Simões; Rui M. M. Brito. "The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23031731.
    10.3390/ijms23031731
  17. Trigueiro-Louro, João; Santos, Luís A.; Almeida, Filipe; Correia, Vanessa; Brito, Rui M.M.; Rebelo-de-Andrade, Helena. "NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral replication". Virology 565 (2022): 106-116. http://dx.doi.org/10.1016/j.virol.2021.11.001.
    Open access • Published • 10.1016/j.virol.2021.11.001
  18. Elisabete Ferreira; Zaida L. Almeida; Pedro F. Cruz; Marta Silva e Sousa; Paula Veríssimo; Rui M. M. Brito. "Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms23010391.
    10.3390/ijms23010391
  19. Abel G. M. Ferreira; Jaime Batista Santos; Johnny Baptista; Saman Khalighi; Rui M. M. Brito; Pedro F. Cruz. "Effect of Isobutanol Addition on the Biodiesel Density". Journal of Chemical & Engineering Data (2021): https://doi.org/10.1021/acs.jced.1c00588.
    10.1021/acs.jced.1c00588
  20. Piotr Gierlich; Ana I. Mata; Claire Donohoe; Rui M. M. Brito; Mathias O. Senge; Lígia C. Gomes-da-Silva. "Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment". Molecules 25 22 (2020): 5317-5317. https://doi.org/10.3390/molecules25225317.
    10.3390/molecules25225317
  21. Alves, Nuno G.; Mata, Ana I.; Luís, João P.; Brito, Rui M. M.; Simões, Carlos J. V.. "An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpretation and Prediction: The Use of Molecular Interaction Fields to Detect HIV-1 Protease Binding-Site Dissimilarities". Frontiers in Chemistry 8 (2020): http://dx.doi.org/10.3389/fchem.2020.00243.
    Open access • Published • 10.3389/fchem.2020.00243
  22. Zaida L. Almeida; Rui M. M. Brito. "Structure and Aggregation Mechanisms in Amyloids". Molecules 25 5 (2020): 1195-1195. https://doi.org/10.3390/molecules25051195.
    10.3390/molecules25051195
  23. Nícia Rosário-Ferreira; António J. Preto; Rita Melo; Irina S. Moreira; Rui M. M. Brito. "The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21041511.
    10.3390/ijms21041511
  24. Frangolho, Ana; Correia, Bruno E.; Vaz, Daniela C.; Almeida, Zaida L.; Brito, Rui M. M.. "Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity". (2020): http://hdl.handle.net/10400.8/5230.
    10.3390/molecules25235698
  25. Brito, Catarina; Bertotti, Taciana; Primitivo, Maria João; Neves, Marta; Pires, Cristiana L.; Cruz, Pedro F.; Martins, Patrícia A. T.; et al. "Corema album spp: Edible wild crowberries with a high content in minerals and organic acids". (2020): http://hdl.handle.net/10400.8/5247.
    10.1016/j.foodchem.2020.128732
  26. Adão, Regina; Cruz, Pedro F.; Vaz, Daniela C.; Fonseca, Fátima; Pedersen, Jannik Nedergaard; Ferreira-da-Silva, Frederico; Brito, Rui M. M.; et al. "DIBMA nanodiscs keep a-synuclein folded". (2020): http://hdl.handle.net/10400.8/5233.
    10.1016/j.bbamem.2020.183314
  27. Matti Knaapila; Beverly Stewart; Vasil M. Garamus; M. Luísa Ramos; Pedro F. Cruz; Rui M. M. Brito; Lícinia L. G. Justino; et al. "Poly(9-undecyl-9-methyl-fluorene) and poly(9-pentadecyl-9-methyl-fluorene): Synthesis, solution structure, and effect of side chain asymmetry on aggregation behavior". Journal of Polymer Science Part B: Polymer Physics 57 13 (2019): 826-837. https://doi.org/10.1002/polb.24838.
    10.1002/polb.24838
  28. Rui M M Brito. "Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous". Amyloid (2019): http://dx.doi.org/10.1080/13506129.2019.1583193.
    10.1080/13506129.2019.1583193
  29. Rui M M Brito. "Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS". Amyloid (2019): http://dx.doi.org/10.1080/13506129.2019.1583195.
    10.1080/13506129.2019.1583195
  30. Rui M M Brito. "Development of sugar based biodegradable nanoencapsulators: Understanding the role of the alcohol injection method on the preparation of aqueous dispersions of sorbitan ester vesicles". (2019): http://dx.doi.org/10.1016/j.molliq.2018.12.049.
    10.1016/j.molliq.2018.12.049
  31. Trigueiro-Louro, João M.; Correia, Vanessa; Santos, Luís A.; Guedes, Rita C.; Brito, Rui M.M.; Rebelo-de-Andrade, Helena. "To hit or not to hit: large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential". (2019): http://hdl.handle.net/10400.18/6649.
    10.1016/j.virol.2019.04.009
  32. Rui M M Brito. "One Peptide Reveals the Two Faces of a-Helix Unfolding–Folding Dynamics". (2018): http://dx.doi.org/10.1021/acs.jpcb.8b00229.
    10.1021/acs.jpcb.8b00229
  33. Jorge M; Garrido NM; Simões CJ; Silva CG; Brito RM. "Predicting hydrophobic solvation by molecular simulation: 1. Testing united-atom alkane models.". Journal of computational chemistry (2017): http://europepmc.org/abstract/med/28032384.
    10.1002/jcc.24690
  34. Chaves OA; Jesus CS; Cruz PF; Sant'Anna CM; Brito RM; Serpa C. "Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA.". (2016): http://europepmc.org/abstract/med/27376757.
    10.1016/j.saa.2016.06.028
  35. Simões CJ; Almeida ZL; Costa D; Jesus CS; Cardoso AL; Almeida MR; Saraiva MJ; Pinho E Melo TM; Brito RM. "A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition.". (2016): http://europepmc.org/abstract/med/27020050.
    10.1016/j.ejmech.2016.02.074
  36. G. Silva, Cândida; J.V. Simoes, Carlos; Carreiras, Pedro; M.M. Brito, Rui. "Enhancing Scoring Performance of Docking-Based Virtual Screening Through Machine Learning". Current Bioinformatics 11 4 (2016): 408-420. http://dx.doi.org/10.2174/1574893611666160212234816.
    Published • 10.2174/1574893611666160212234816
  37. Dias DM; Furtado J; Wasielewski E; Cruz R; Costello B; Cole L; Faria TQ; et al. "Biophysical characterization of laforin-carbohydrate interaction.". (2016): http://europepmc.org/abstract/med/26578817.
    10.1042/bj20141555
  38. Silva, Cândida; Monteiro, Antonio Jose; Manahl, Caroline; Lostal, Eduardo; Schäfer, Teresa; Andrade, Nazareno; Brasileiro, Francisco; et al. "Cell Spotting: educational and motivational outcomes of cell biology citizen science project in the classroom". Journal of Science Communication 15 01 (2016): A02. http://dx.doi.org/10.22323/2.15010202.
    Published • 10.22323/2.15010202
  39. Magalhães, Solange S.; Alves, Luis; Sebastião, Marco; Medronho, Bruno; Almeida, Zaida L.; Faria, Tiago Q.; Brito, Rui M. M.; Moreno, Maria J.; Antunes, Filipe E.. "Effect of ethyleneoxide groups of anionic surfactants on lipase activity". (2016): http://hdl.handle.net/10400.1/9301.
    10.1002/btpr.2310
  40. Jesus, Catarina S. H.; Almeida, Zaida L.; Vaz, Daniela C.; Faria, Tiago Q.; Brito, Rui M. M.. "A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation". (2016): http://hdl.handle.net/10400.8/4253.
    10.3390/ijms17091428
  41. Manco, Licínio; Bento, Celeste; Victor, Bruno L.; Pereira, Janet; Relvas, Luís; Brito, Rui M.; Seabra, Carlos; et al. "Hereditary nonspherocytic hemolytic anemia caused by red cell glucose-6-phosphate isomerase (GPI) deficiency in two Portuguese patients: Clinical features and molecular study". (2016): http://hdl.handle.net/10316/45864.
    10.1016/j.bcmd.2016.06.002
  42. Otávio A. Chaves; Catarina S. H. Jesus; Elsa S. Henriques; Rui M. M. Brito; Carlos Serpa; Chaves OA; Jesus CS; et al. "In situ ultra-fast heat deposition does not perturb the structure of serum albumin". Photochemical & Photobiological Sciences 15 12 (2016): 1524-1535. https://doi.org/10.1039/C6PP00209A.
    10.1039/C6PP00209A
  43. Faria TQ; Almeida ZL; Cruz PF; Jesus CS; Castanheira P; Brito RM. "A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model.". (2015): http://europepmc.org/abstract/med/25694367.
    10.1039/c4cp04549a
  44. Vilaça, Maria Helena Pereira; Pereira, G.; Castro, T. G.; Hermenegildo, Bruno Filipe Costa; Shi, J.; Faria, T. Q.; Micaelo, N. M.; et al. "New self-assembled supramolecular hydrogels based on dehydropeptides". (2015): http://hdl.handle.net/1822/39807.
    10.1039/c5tb00501a
  45. Silva, Cândida G.; Brito, Rui M. M.. "SOCIENTIZE participatory experiments, dissemination and networking activities in perspective". Human Computation 1 2 (2014): http://dx.doi.org/10.15346/hc.v1i2.4.
    Open access • Published • 10.15346/hc.v1i2.4
  46. Mompeán M; Buratti E; Guarnaccia C; Brito RM; Chakrabartty A; Baralle FE; Laurents DV. ""Structural characterization of the minimal segment of TDP-43 competent for aggregation".". (2014): http://europepmc.org/abstract/med/24440310.
    10.1016/j.abb.2014.01.007
  47. Toubarro, D.; Avila, M.M.; Hao, Y.J.; Balasubramanian, N.; Jing, Y.; Montiel, R.; Faria, T.Q.; Brito, R.M.; Simões, N.. "A Serpin Released by an Entomopathogen Impairs Clot Formation in Insect Defense System". PLoS ONE 8 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880500159&partnerID=MN8TOARS.
    10.1371/journal.pone.0069161
  48. Silva, D.S.; Pereira, L.M.G.; Moreira, A.R.; Ferreira-da-Silva, F.; Brito, R.M.; Faria, T.Q.; Zornetta, I.; et al. "The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-¿b P65". PLoS Pathogens 9 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880954175&partnerID=MN8TOARS.
    10.1371/journal.ppat.1003128
  49. Jesus, C.S.H.; Vaz, D.C.; Saraiva, M.J.M.; Brito, R.M.M.. "The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin". Advances in Biomedical Spectroscopy 7 (2013): 267-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888105124&partnerID=MN8TOARS.
    10.3233/978-1-61499-184-7-267
  50. Fraga, Ana Sofia; Esteves, Ana Cristina; Micaelo, Nuno; Cruz, Pedro F.; Brito, Rui M. M.; Nutley, Margaret; Cooper, Alan; Barros, Marlene M. T.; Pires, Euclides M. V.. "Functional and conformational changes in the aspartic protease cardosin A induced by TFE". (2012): http://hdl.handle.net/10773/26797.
    10.1016/j.ijbiomac.2011.12.018
  51. Jesus, Catarina S. H.; Vaz, Daniela C.; Saraiva, Maria J. M.; Brito, Rui M. M.. "The V30M amyloidogenic mutation decreases the rate of refolding kinetics of the tetrameric protein transthyretin". (2012): http://hdl.handle.net/10400.8/4261.
    10.1155/2012/502497
  52. Maia, J.; Vazão, H.; Pedroso, D.C.S.; Jesus, C.S.H.; Brito, R.M.M.; Grãos, M.; Gil, M.H.; Ferreira, L.. "VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells". Biomacromolecules 13 9 (2012): 2906-2916. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866111153&partnerID=MN8TOARS.
    10.1021/bm3009268
  53. Harley, C.A.; Jesus, C.S.H.; Carvalho, R.; Brito, R.M.M.; Morais-Cabral, J.H.. "Changes in channel trafficking and protein stability caused by lqt2 mutations in the pas domain of the herg channel". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857773278&partnerID=MN8TOARS.
    10.1371/journal.pone.0032654
  54. Rui Camacho; Max Pereira; Vítor Santos Costa; Nuno A. Fonseca; Carlos Adriano; Carlos J. V. Simões; Rui M. M. Brito; et al. "A relational learning approach to Structure-Activity Relationships in drug design toxicity studies.". Journal of integrative bioinformatics 8 3 (2011): https://repositorio-aberto.up.pt/handle/10216/67124.
    10.2390/biecoll-jib-2011-182
  55. Camacho, R.; Pereira, M.; Costa, V.S.; Fonseca, N.A.; Simões, C.J.V.; Brito, R.M.M.. "Assessing the effect of 2D fingerprint filtering on ilp-based structure-activity relationships toxicity studies in drug design". Advances in Intelligent and Soft Computing 93 (2011): 355-363. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052957010&partnerID=MN8TOARS.
    10.1007/978-3-642-19914-1_46
  56. Henriques, E.S.; Brito, R.M.M.; Soares, H.; Ventura, S.; De Oliveira, V.L.; Parkhouse, R.M.E.. "Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus". Protein Science 20 2 (2011): 247-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251539240&partnerID=MN8TOARS.
    10.1002/pro.554
  57. Carvalho, Vera; Castanheira, Pedro; Faria, Tiago Q.; Gonçalves, Catarina; Madureira, Pedro; Faro, Carlos; Domingues, Lucília; et al. "Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system". (2010): http://hdl.handle.net/1822/11211.
    10.1016/j.ijpharm.2010.08.040
  58. Simões, C.J.V.; Mukherjee, T.; Brito, R.M.M.; Jackson, R.M.. "Toward the discovery of functional transthyretin amyloid inhibitors: Application of virtual screening methods". Journal of Chemical Information and Modeling 50 10 (2010): 1806-1820. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958566357&partnerID=MN8TOARS.
    10.1021/ci100250z
  59. Fraga, H.; Faria, T.Q.; Pinto, F.; Almeida, A.; Brito, R.M.M.; Damas, A.M.. "FH8 - A small EF-hand protein from Fasciola hepatica". FEBS Journal 277 24 (2010): 5072-5085. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650027462&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2010.07912.x
  60. Swain, M.; Silva, C.G.; Loureiro-Ferreira, N.; Ostropytskyy, V.; Brito, J.; Riche, O.; Stahl, F.; Dubitzky, W.; Brito, R.M.M.. "P-found: Grid-enabling distributed repositories of protein folding and unfolding simulations for data mining". Future Generation Computer Systems 26 3 (2010): 424-433. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449533843&partnerID=MN8TOARS.
    10.1016/j.future.2009.08.008
  61. Rodrigues, J.R.; Simões, C.J.V.; Silva, C.G.; Brito, R.M.M.. "Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations". Protein Science 19 2 (2010): 202-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749161776&partnerID=MN8TOARS.
    10.1002/pro.289
  62. Fernandes, E.; Jorge, A.M.; Silva, C.G.; Brito, R.M.. "A knowledge discovery method for the characterization of protein unfolding processes". Advances in Soft Computing 49 (2009): 180-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149178827&partnerID=MN8TOARS.
    10.1007/978-3-540-85861-4_22
  63. Soares, M.I.L.; Lopes, S.M.M.; Cruz, P.F.; Brito, R.M.M.; Pinho e Melo, T.M.V.D.. "Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles". Tetrahedron 64 41 (2008): 9745-9753. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849084336&partnerID=MN8TOARS.
    10.1016/j.tet.2008.07.079
  64. Swain, M.; Ostropytskyy, V.; Silva, C.G.; Stahl, F.; Riche, O.; Brito, R.M.M.; Dubitzky, W.. "Grid computing solutions for distributed repositories of protein folding and unfolding simulations". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 5103 LNCS PART 3 (2008): 70-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-47749119648&partnerID=MN8TOARS.
    10.1007/978-3-540-69389-5_10
  65. Ferreira, P.G.; Silva, C.G.; Brito, R.M.M.; Azevedo, P.J.. "A closer look on protein unfolding simulations through hierarchical clustering". 2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology, CIBCB 2007 (2007): 461-468. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149181357&partnerID=MN8TOARS.
  66. Vaz, Daniela C.; Rodrigues, J. Rui; Sebald, Walter; Dobson, Christopher M.; Brito, Rui M. M.. "Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin-4". (2006): http://hdl.handle.net/10400.8/4260.
    10.1110/ps.051593306
  67. Ferreira, P.G.; Azevedo, P.J.; Silva, C.G.; Brito, R.M.M.. "Mining approximate motifs in time series". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 4265 LNAI (2006): 89-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750736111&partnerID=MN8TOARS.
  68. Bertrand, A.; Brito, R.M.; Alix, A.J.P.; Lancelin, J.M.; Carvalho, R.A.; Geraldes, C.F.G.C.; Lakhdar-Ghazal, F.. "Conformation study of HA(306-318) antigenic peptide of the haemagglutinin influenza virus protein". Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 65 3-4 (2006): 711-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749496759&partnerID=MN8TOARS.
    10.1016/j.saa.2005.12.036
  69. Silva, C.G.; Ostropytskyy, V.; Loureiro-Ferreira, N.; Berrar, D.; Swain, M.; Dubitzky, W.; Brito, R.M.M.. "P-found: The protein folding and unfolding simulation repository". Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 (2006): 101-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249173859&partnerID=MN8TOARS.
    10.1109/CIBCB.2006.330978
  70. Correia, B.E.; Loureiro-Ferreira, N.; Rodrigues, J.R.; Brito, R.M.M.. "A structural model of an amyloid protofilament of Transthyretin". Protein Science 15 1 (2006): 28-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-29344445475&partnerID=MN8TOARS.
    10.1110/ps.051787106
  71. Stahl, F.; Berrar, D.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Grid warehousing of molecular dynamics protein unfolding data". 2005 IEEE International Symposium on Cluster Computing and the Grid, CCGrid 2005 1 (2005): 496-503. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845479450&partnerID=MN8TOARS.
    10.1109/CCGRID.2005.1558594
  72. Azevedo, P.J.; Silva, C.G.; Rodrigues, J.R.; Loureiro-Ferreira, N.; Brito, R.M.M.. "Detection of hydrophobic clusters in molecular dynamics protein unfolding simulations using association rules". Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 3745 LNBI (2005): 329-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745292575&partnerID=MN8TOARS.
  73. Berrar, D.; Stahl, F.; Silva, C.; Rodrigues, J.R.; Brito, R.M.M.; Dubitzky, W.. "Towards data warehousing and mining of protein unfolding simulation data". Journal of Clinical Monitoring and Computing 19 4-5 (2005): 307-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-30344471278&partnerID=MN8TOARS.
    10.1007/s10877-005-0676-z
  74. Brito, R.M.M.; Dubitzky, W.; Rodrigues, J.R.. "Protein folding and unfolding simulations: A new challenge for data mining". OMICS A Journal of Integrative Biology 8 2 (2004): 153-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342989779&partnerID=MN8TOARS.
    10.1089/1536231041388311
  75. Brito, Rui; Damas, Ana; Saraiva, Maria. "Amyloid Formation by Transthyretin: From Protein Stability to Protein Aggregation". Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 3 4 (2003): 349-360. http://dx.doi.org/10.2174/1568013033483230.
    Published • 10.2174/1568013033483230
  76. Quintas, Alexandre; Vaz, Daniela C.; Cardoso, Isabel; Saraiva, Maria João M.; Brito, Rui M. M.. "Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants". (2001): http://hdl.handle.net/10400.8/4259.
    10.1074/jbc.M101024200
  77. Shnyrov, V.L.; Villar, E.; Zhadan, G.G.; Sanchez-Ruiz, J.M.; Quintas, A.; Saraiva, M.J.M.; Brito, R.M.M.; et al. "Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin". Biophysical Chemistry 88 1-3 (2000): 61-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034672768&partnerID=MN8TOARS.
    10.1016/S0301-4622(00)00199-X
  78. Egas, C.; Lavoura, N.; Resende, R.; Brito, R.M.M.; Pires, E.; Pedroso De Lima, M.C.; Faro, C.. "The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage". Journal of Biological Chemistry 275 49 (2000): 38190-38196. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034623993&partnerID=MN8TOARS.
    10.1074/jbc.M006093200
  79. Gasmi-Seabrook, Geneviève M. C.; Howarth, Jack W.; Finley, Natosha; Abusamhadneh, Ekram; Gaponenko, Vadim; Brito, Rui M. M.; Solaro, R. John; et al. "Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I". Biochemistry 38 26 (1999): 8313-8322. http://hdl.handle.net/10316/10370.
    10.1021/bi9902642
  80. Quintas, A.; Saraiva, M.J.M.; Britot, R.M.M.. "The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis". Journal of Biological Chemistry 274 46 (1999): 32943-32949. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032725562&partnerID=MN8TOARS.
    10.1074/jbc.274.46.32943
  81. Gasmi-Seabrook, G.M.C.; Howarth, J.W.; Finley, N.; Abusamhadneh, E.; Gaponenko, V.; Brito, R.M.M.; Solaro, R.J.; Rosevear, P.R.. "Erratum: Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I (Biochemistry (June 29, 1999) 38:26 (8313-8322))". Biochemistry 38 43 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0033607223&partnerID=MN8TOARS.
    10.1021/bi995088b
  82. Quintas, A.; Saraiva, M.J.M.; Brito, R.M.M.. "The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution". FEBS Letters 418 3 (1997): 297-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030694782&partnerID=MN8TOARS.
    10.1016/S0014-5793(97)01398-7
  83. Brito, R.M.M.; Krudy, G.A.; Negele, J.C.; Putkey, J.A.; Rosevear, P.R.. "Calcium plays distinctive structural roles in the N- and C-terminal domains of cardiac troponin C". Journal of Biological Chemistry 268 28 (1993): 20966-20973. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027434034&partnerID=MN8TOARS.
  84. Krudy, G.A.; Brito, R.M.M.; Putkey, J.A.; Rosevear, P.R.. "Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding". Biochemistry 31 6 (1992): 1595-1602. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026546294&partnerID=MN8TOARS.
  85. Brito, R.M.M.; Putkey, J.A.; Strynadka, N.C.J.; James, M.N.G.; Rosevear, P.R.. "Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II". Biochemistry 30 42 (1991): 10236-10245. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025840596&partnerID=MN8TOARS.
    10.1021/bi00106a023
  86. Brito, R.M.M.; Rudolph, F.B.; Rosevear, P.R.. "Conformation of NADP+ bound to a type II dihydrofolate reductase". Biochemistry 30 6 (1991): 1461-1469. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025758909&partnerID=MN8TOARS.
  87. Lee Sweeney, H.; Brito, R.M.M.; Rosevear, P.R.; Putkey, J.A.. "The low-affinity Ca2+-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: Site I alone cannot trigger contraction". Proceedings of the National Academy of Sciences of the United States of America 87 24 (1990): 9538-9542. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025572631&partnerID=MN8TOARS.
  88. Brito, R.M.M.; Reddick, R.; Bennett, G.N.; Rudolph, F.B.; Rosevear, P.R.. "Characterization and stereochemistry of cofactor oxidation by a type II dihydrofolate reductase". Biochemistry 29 42 (1990): 9825-9831. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025175189&partnerID=MN8TOARS.
  89. Brito, R.M.M.; Vaz, W.L.C.. "Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine". Analytical Biochemistry 152 2 (1986): 250-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022625326&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Fernandes, Pedro Miguel Pinto. "Em busca de determinantes estruturais no reconhecimento e ligação de amilóide: ß-2 microglobulina como caso de estudo". Master, 2016. http://hdl.handle.net/10316/30851.
  2. Ferreira, Elisabete Priscila Pinto. "Identification and characterization of small molecule interactions with transthyretin amyloid fibers". Master, 2015. http://hdl.handle.net/10316/30293.
  3. Almeida, Zaida C. Lourenço de. "Cinética de agregação da proteína transtirretina: contribuição para a compreensão dos processos de formação de amilóide". Master, 2010. http://hdl.handle.net/10316/15315.

Intellectual property

Patent
  1. Brito, Rui; Carlos J. V. Simões; Pinho e Melo, Teresa M. V. D.; Bruno Lourenço Silva Victor; Almeida, Zaida C. Lourenço de; Ana Lúcia Cabral Cardoso Lopes; Bruno Filipe Oliveira Nascimento. 2023. "2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof". United States.
    Granted/Issued
  2. Rui M M Brito; et al.. 2022. "2-oxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof".
    Pending
  3. Brito, Rui; Simões, Carlos J. V.; Pinho e Melo, Teresa M. V. D.; Victor, Bruno L.; Almeida, Zaida L.; Ana Lúcia Cabral Cardoso Lopes; Nascimento, Bruno F.O.. 2021. "2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof". United States.
    Granted/Issued
  4. Simões, Carlos J. V. ; Almeida, Zaida C. Lourenço de; Pinho e Melo, Teresa M. V. D.; Costa, Dora C. S.; Ana Lúcia Cabral Cardoso Lopes; Rui M M Brito. 2020. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP)".
    Granted/Issued
  5. Simões, Carlos J. V. ; Almeida, Zaida L.; Pinho e Melo, Teresa M. V. D.; Costa, Dora C. S.; Ana Lúcia Cabral Cardoso Lopes; Brito, Rui. 2019. "Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP)". United States.
    Granted/Issued
  6. Rui M M Brito; et al.. 2016. "2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof".
    Pending
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2019 OSA and Transthyretin
Co-supervisor
 Química Medicinal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 O papel dos halogénios no desenho de fármacos. O caso da ligação de pequenos ligantes à Transtirretina.
Supervisor
 Química Medicinal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Estudo das alterações metabólicas post mortem no fígado por espectroscopia de RMN
Supervisor
 Química Forense (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Towards the discovery of novel anti-Influenza agents using a reverse virtual fragment screening approach
Supervisor
 Química Medicinal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Em Busca de Determinantes Estruturais no Reconhecimento e Ligação Amilóide: ß-2 Microglobulina como Caso de Estudo
Supervisor
 Química Medicinal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2015 Identification and Characterization of Small Molecule Interactions With Transthyretin Amyloid Fibers
Supervisor
 Química Medicinal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2007 Protein Conformational Plasticity and Aggregation. Transthyretin and Delta-Toxin as Two Case Studies
Supervisor
 Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2006 Virtual Screening with Sense and Sensibility in the Search of New Amyloid Inhibitors.
Supervisor
 Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2004 Knowledge Extraction and Data Mining Strategies for the Analysis of Protein Folding and Unfolding Simulation Data. Transthyretin as a Case Study
Supervisor
 Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002 - 2002 Chaves para a Compreensão dos Mecanismos Moleculares de Formação de Fibras Amilóides pela Proteína Transtirretina
Supervisor
 Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2001 - 2001 The Role of Disulphides on Structure, Packing and Stability of Human Interleukin-4
Supervisor
 Química (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal