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Silvia C. Coelho graduated in Chemical Engineering (2008) from the Faculty of Engineering of University of Porto (FEUP). She is an integrated member of LEPABE since 2008 and started scientific research with the development and characterization of nanoparticles as drug delivery and systems. In 2013, Silvia C. Coelho completed her PhD degree in Chemical and Biological Engineering (FEUP) in collaboration with Centro de Investigación Cooperativa en Biomateriales (Spain); i3S (Portugal); and Oslo University Hospital (Norway) for 6 months through YGGDRASIL mobility programme. As a post-doctoral researcher (from January 2014 to March 2019) she investigated the efficacy of functionalized AuNPs/biomolecules against pancreatic, colon and non-small-lung carcinoma cells. She was involved as a team member in an EU project "Nanoparticle-Enhanced molecular Fluorescence-Endoscopy for detection of early-stage colorectal adenocarcinomas" which was co-financed by Portuguese Cancer League. Her research work was the development of fluorescent AuNPs for detection of early-stage colorectal adenocarcinoma in collaboration with European partners such as Medical University Innsbruck, SINTEF, University Clinic Erlangen and CESAR. As junior researcher (from April 2019 to March 2022) Silvia C. Coelho worked in the field of microencapsulation by a electrospinning technique for food and nutraceutical applications at LEBABE (FEUP). She has high knowledge in different techniques of characterization such as ATR-FTIR, AFM, X-ray photoelectron spectroscopy. Silvia C. Coelho published 21 publications in international scientific journals with high impact factor (16 as first author and 5 as corresponding author) and 1st quartile and 2 in proceedings in international journals with scientific citation index , 7 conference papers and has 10 participations in international conferences, 2 oral communication in international meetings and 2 more by invitation in national courses. She achieved an h-index of 11. Silvia C. Coelho was supervisor in 2 Master thesis (concluded) and co-supervisor of 4 Erasmus student, at FEUP. She is a guest editor of Pharmaceutics Journal.
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Identification

Personal identification

Full name
Silvia Maria Castro Coelho Pacheco
Date of birth
1984/08/24
Gender
Female

Citation names

  • Coelho, Silvia C.
  • Coelho Sílvia

Author identifiers

Ciência ID
951F-1A51-3A04
ORCID iD
0000-0002-9985-3358
Scopus Author Id
52063094800

Email addresses

  • silviaccoelhop@gmail.com (Professional)
  • silviac@fe.up.pt (Professional)

Telephones

Mobile phone
  • 919463645 (Personal)

Addresses

  • Rua São Vicente de Ferrer, 835A, 1E, 4410-104, São Félix da Marinha, Vila Nova de Gaia, Portugal (Personal)

Websites

Knowledge fields

  • Engineering and Technology - Chemical Engineering - Chemical Engineering
  • Engineering and Technology - Nano-technology - Nano-materials
  • Engineering and Technology - Other Engineering and Technologies - Food and Beverages
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Projects

Grant

Designation Funders
2014/01 - 2017/07 Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma
TRANSCAN/0001/2012
Post-doc Fellow

Contract

Designation Funders
2019/04/01 - 2021/07/22 Development of controlled delivery functional systems by microencapsulation of natural and active compounds with therapeutic, nutritional and technological interest
PTDC/EQU-EPQ/28715/2017
Researcher
Universidade do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/04 - 2019/09 LEPABE-2-ECO-INNOVATION, NORTE-01-0145-FEDER-000005
POCI-01-0145-FEDER-006939
Post-doc Fellow
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2014/01 - 2019/03 Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia, UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939
NORTE-01-0145-FEDER-000005
POCI-01-0145-FEDER-006939
Post-doc Fellow
FCT - Fundação para a Ciência e Tecnologia
2014/01 - 2015/06 (Bio) Chemical Engineering: Multi-Scale Approaches for Sustainable Environment and Health
NORTE-07-0124-FEDER-000025
Post-doc Fellow
2010/10 - 2013/12 Biomolecules delivery by functionalized inorganic/organic nanoparticles
202638
PTDC/QUI/BIQ/115449/2009
PhD Student Fellow
Universidade do Porto Faculdade de Engenharia, Portugal
 FCT - Fundação para a Ciência e Tecnologia
Concluded
2008/11 - 2010/10 Polymer carriers for the delivery of biopharmaceutical peptides
PTDC/BIO/69359/2006
Research Fellow
FCT Science and Technology Foundation
Outputs

Publications

Conference abstract
  1. Coelho, Silvia C.. "SYNERGETIC ACTIVITY OF PROTEASOME INHIBITOR AND NANOPARTICLES IN PANCREATIC ADENOCARCINOMA CELLS". Paper presented in 1st ASPIC International Congress, 2014.
  2. Coelho, SC; Rocha, S; Pereira, MC; Coelho, MA; Coelho, Silvia C.. "Proteasome inhibitor delivery by functionalized gold nanoparticles in pancreatic cancer cells". Paper presented in 9th EBSA European Biophysics Congress, 2013.
  3. Coelho, Silvia C.. "Gold nanoparticles enhance the effects of anticancer drugs". Paper presented in 12th European Symposium on Controlled Drug Delivery, 2012.
Conference paper
  1. Coelho, Silvia C.. "Delivery of a proteasome inhibitor in cancer cells using pegylated gold nanoparticles". Paper presented in 2013 AAPS National Biotechnology Conference, 2013.
  2. Coelho, Silvia C.. "Functionalized gold nanoparticles for drug delivery". Paper presented in 3rd Portuguese Bioengineering meeting, 2013.
  3. Coelho, S.C.; Rocha, S.; Carmo Pereira, M.; Coelho, M.A.N.; Juzenas, P.. "Functionalized gold nanoparticles for drug delivery". 2013.
    10.1109/enbeng.2013.6518389
  4. Coelho, Silvia C.. "Delivery of biomolecules by functionalized inorganic nanoparticles". Paper presented in IEEE 2nd Portuguese Meeting in Bioengineering, 2012.
  5. Coelho, S.C.; Pereira, M.C.; Rocha, S.; Coelho, M.A.N.. "Delivery of biomolecules by functionalized inorganic nanoparticles". 2012.
    10.1109/ENBENG.2012.6331365
  6. de Castro Coelho, SMD; Rocha, S; Coelho, M; Pereira, MD. "Atomic Force Microscopy in study of gum-arabic/chitosan complexes". Paper presented in 8th EBSA European Biophysics Congress, 2011.
    Accepted
Conference poster
  1. Coelho, Silvia C.. "Zein-based electrospun fibres/capsules for food applications". Paper presented in 1st International/11th National Food Engineering Congress, 2019.
  2. Coelho, Silvia C.. "Nanoparticle-Enhanced molecular Fluorescence-Endoscopy for detection of early-stage colorectal adenocarcinomas". Paper presented in 3rd ASPIC International conference, 2018.
  3. Faculdade de Engenharia. "Structural Characterization of Functionalized Gold Nanoparticles for Drug Delivery in Cancer Therapy: NMR Based Approach". Paper presented in 21st Ostwald colloquium ‘Biomolecules, Macromolecules and Particles at Fluid Interfaces’, 2015.
  4. Coelho, Silvia C. (951F-1A51-3A04). "SYNERGETIC ACTIVITY OF PROTEASOME INHIBITOR AND NANOPARTICLES IN PANCREATIC ADENOCARCINOMA CELLS". Paper presented in 1st International congress Drug Delivery, 2014.
  5. Coelho, Silvia C. (951F-1A51-3A04). "Atomic Force Microscopy in study of gum-arabic/chitosan complexes". Paper presented in 8th European Biophysics Congress (EBSA2011), 2011.
Journal article
  1. Sílvia Castro Coelho; Berta Nogueiro Estevinho. "A Brief Review on the Electrohydrodynamic Techniques Used to Build Antioxidant Delivery Systems from Natural Sources". Molecules (2023): https://doi.org/10.3390/molecules28083592.
    10.3390/molecules28083592
  2. Sílvia Castro Coelho; Fernando Rocha; Berta N. Estevinho. "Development of starch microstructures containing vitamin B3 by electrospinning technique for application in functional food". Journal of Chemical Technology & Biotechnology (2022): https://doi.org/10.1002/jctb.7224.
    10.1002/jctb.7224
  3. Sílvia Castro Coelho; Fernando Rocha; Berta Nogueiro Estevinho. "Electrospinning of Microstructures Incorporated with Vitamin B9 for Food Application: Characteristics and Bioactivities". Polymers (2022): https://doi.org/10.3390/polym14204337.
    10.3390/polym14204337
  4. Sílvia Castro Coelho; Berta Nogueiro Estevinho; Fernando Rocha. "Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review". Foods (2022): https://doi.org/10.3390/foods11091271.
    10.3390/foods11091271
  5. Lídia Cunha; Sílvia Castro Coelho; Maria do Carmo Pereira; Manuel A. N. Coelho. "Nanocarriers Based on Gold Nanoparticles for Epigallocatechin Gallate Delivery in Cancer Cells". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14030491.
    10.3390/pharmaceutics14030491
  6. Coelho, SC; Benaut, P; Laget, S; Estevinho, BN; Rocha, F. "Optimization of electrospinning parameters for the production of zein microstructures for food and biomedical applications". MICRON (2022):
    10.1016/j.micron.2021.103164
  7. Castro Coelho, S.; Nogueiro Estevinho, B.; Rocha, F.. "Encapsulation in food industry with emerging electrohydrodynamic techniques: Electrospinning and electrospraying – A review". Food Chemistry 339 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85089843068&partnerID=MN8TOARS.
    10.1016/j.foodchem.2020.127850
  8. Coelho, SC; Laget, S; Benaut, P; Rocha, F; Estevinho, BN. "A new approach to the production of zein microstructures with vitamin B12, by electrospinning and spray drying techniques". POWDER TECHNOLOGY (2021):
    10.1016/j.powtec.2021.06.056
  9. Machado, Alessandra Cury; Lopes, Marcelo Milanda MR; Durango, Luis Guillermo C; Coelho, Silvia Castro; Damante, Carla Andreotti; Sales-Peres, Silvia Helena C; Coelho, Manuel AN; Forim, Moacir Rossi. "Cytotoxicity evaluation in cancer cells and bactericidal activity of nanoencapsulated extracts from Myracrodruon urundeuva". Journal of Medicinal Plants Studies 9 1 (2020): 47-53. http://dx.doi.org/10.22271/plants.2021.v9.i1a.1249.
    Published • 10.22271/plants.2021.v9.i1a.1249
  10. Sílvia Castro Coelho; Daniel Reis; Maria Carmo Pereira; Manuel A. N. Coelho. "Doxorubicin and Varlitinib Delivery by Functionalized Gold Nanoparticles Against Human Pancreatic Adenocarcinoma". Pharmaceutics (2019): https://www.mdpi.com/1999-4923/11/11/551.
    10.3390/pharmaceutics11110551
  11. Coelho, SC; Reis, DP; Pereira, MC; Coelho, MAN. "Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells". PHARMACEUTICS (2018):
    10.3390/pharmaceutics10030091
  12. Santos-Rebelo, A.; Garcia, C.; Eleutério, C.; Bastos, A.; Coelho, S.C.; Coelho, M.A.N.; Molpeceres, J.; et al. "Development of parvifloron D-loaded smart nanoparticles to target pancreatic cancer". Pharmaceutics 10 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056568086&partnerID=MN8TOARS.
    10.3390/pharmaceutics10040216
  13. Coelho, S.C.; Almeida, G.M.; Pereira, M.C.; Santos-Silva, F.; Coelho, M.A.N.. "Functionalized gold nanoparticles improve afatinib delivery into cancer cells". Expert Opinion on Drug Delivery 13 1 (2016): 133-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955199883&partnerID=MN8TOARS.
    10.1517/17425247.2015.1083973
  14. Coelho, SC; Almeida, GM; Santos Silva, F; Pereira, MC; Coelho, MAN. "Enhancing the efficiency of bortezomib conjugated to pegylated gold nanoparticles: an in vitro study on human pancreatic cancer cells and adenocarcinoma human lung alveolar basal epithelial cells". Expert Opinion on Drug Delivery (2016): https://www.authenticus.pt/P-00K-RE1.
    10.1080/17425247.2016.1178234
  15. Coelho, S.C.; Rangel, M.; Pereira, M.C.; Coelho, M.A.N.; Ivanova, G.. "Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach". Physical Chemistry Chemical Physics 17 29 (2015): 18971-18979. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937130815&partnerID=MN8TOARS.
    10.1039/c5cp02717a
  16. Coelho, S.C.; Pereira, M.C.; Juzeniene, A.; Juzenas, P.; Coelho, M.A.N.. "Supramolecular nanoscale assemblies for cancer diagnosis and therapy". Journal of Controlled Release 213 (2015): 152-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937604153&partnerID=MN8TOARS.
    10.1016/j.jconrel.2015.06.034
  17. Coelho, SC; Rocha, S; Pereira, MC; Juzenas, P; Coelho, MAN. "Enhancing Proteasome-Inhibitor Effect by Functionalized Gold Nanoparticles". JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014): https://www.authenticus.pt/P-009-CQY.
    10.1166/jbn.2014.1743
  18. Coelho, SC; Rocha, S; Sampaio, P; Pereira, MC; Coelho, MAN. "Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers". JOURNAL OF NANOPARTICLE RESEARCH (2014): https://www.authenticus.pt/P-009-CHP.
    10.1007/s11051-014-2368-4
  19. Coelho, SC; Rocha, S; Juzenas, P; Sampaio, P; Almeida, GM; Silva, FS; Pereira, MC; Coelho, MAN. "Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells". EXPERT OPINION ON DRUG DELIVERY (2013): https://www.authenticus.pt/P-006-6YE.
    10.1517/17425247.2013.827659
  20. Coelho, S; Moreno Flores, S; Toca Herrera, JL; Coelho, MAN; Carmo Pereira, MC; Rocha, S. "Nanostructure of polysaccharide complexes". JOURNAL OF COLLOID AND INTERFACE SCIENCE (2011): https://www.authenticus.pt/P-002-JN2.
    Published • 10.1016/j.jcis.2011.07.098
Thesis / Dissertation
  1. Sílvia Maria de Castro Coelho. "Delivery of Biomolecules by functionalized inorganic/organic nanoparticles". PhD, 2013. https://repositorio-aberto.up.pt/handle/10216/86752.
  2. Coelho, Sílvia Maria Castro. "Tecnologias alternativas de remoção de produtos farmacêuticos em matrizes aquosas". Master, 2008. http://hdl.handle.net/10216/58971.