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Katharina Willmann graduated in Biology at Heidelberg University (Germany) and holds a Ph.D. in Molecular Immunology awarded by UCL (London, UK) in 2012. Katharina has 14 years of pre- and post-doctoral international research experience in immunology and molecular medicine, in Germany, UK, Austria & Portugal. Her research interests developed from biochemistry of antibody diversification over human immunology towards systems biology of inflammatory diseases. Katharina's PhD work at CRUK London Research Institute has led to new insights on the enzyme Activation Induced Deaminase (AID) in Antibody Diversification (1 resulting first-author peer-reviewed publication, 1 book chapter). In her postdoctoral work at CeMM, Vienna, she worked on the molecular mechanisms of Primary Immunodeficiencies, studying hitherto uncharacterized rare patients by human genetics, immunological and biochemical methods (2 resulting first author and 1 co-author peer-reviewed publications). She also developed systematic approaches to immune disorders using proteomics, haploid and CRISPR/Cas9 forward genetic screens (1 resulting first author and 1 co-author peer-reviewed publications). At Instituto Gulbenkian de Ciência (IGC), Portugal, she studies tissue damage control/disease tolerance pathways with L. Moita, MD PhD (1 resulting first author and 3 resulting co-author peer reviewed publication). She was awarded a Portuguese FCT CEEC individual researcher position to study the role of candidate molecular mediators of cytoprotection, and an Exploratory Research Grant from FCT to study mitochondrial uncoupling in the pathogenesis of sepsis. Overall, since obtaining her University degree, she has published 10 papers in international peer-reviewed journals with an accumulated IF of 93 (Web of Science) and with 498 citations; h-index=7 (Google Scholar). Of these, 5 were published as first author (2012-2024), and 8 were published in the top 9% journals in their research field. She is certified by DGAV to work with animal models and to coordinate preclinical animal projects. Until present, she has co-supervised 2 PhD students, taught in 1 PhD program course, served as invited reviewer for 2 Journals, is organizer of 1 scientific conference, and initiated several interdisciplinary collaborations (Proteomics: André Müller, Head of Proteomics and Metabolomics, CeMM, Vienna; Genetic DNA instability disorders: Dr. Joanna Loizou, Medical University Vienna, Clinical: Prof. Pedro Póvoa, CHRC, HSFX, Lisbon). Throughout her career, she was recognised with a Cancer Research UK predoctoral fellowship, an Austrian FWF Lise Meitner Individual Post-doctoral Fellowship, and secured 1 research grant as PI (funded by FCT) and 1 as co-Investigator funded by the Austrian OeNB. Moreover, she was selected to talk at 1 national and 2 international scientific meetings and obtained 3 conference prizes.
Identification

Personal identification

Full name
Katharina Laura Willmann

Citation names

  • Willmann, Katharina

Author identifiers

Ciência ID
981B-0B1A-2044

Addresses

  • IGC Instituto Gulbenkian de Ciência. RUA DA QUINTA GRANDE, 6, 2780-156, OEIRAS, Oeiras, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Pathology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
German (Mother tongue)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1) Beginner (A1)
French Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Beginner (A1)
Portuguese Intermediate (B1) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Beginner (A1)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2007/11/15 - 2012/04/28
Concluded
Cancer Research UK London Research Institute PhD programme (Doctor of Philosophy)
Major in Molecular Immunology
University College London Faculty of Life Sciences, United Kingdom
"Regulation of Activation Induced Cytosine Deaminase: analysis of cofactors for transcriptional targeting and DNA lesion resolution" (THESIS/DISSERTATION)
N/A
2002 - 2007/10/31
Concluded
Diplom Biologie (Master)
Major in Molecular Biology
Ruprecht Karls Universität Heidelberg, Germany
"Exploring phylogenetic footprinting in the polychaete Platynereis dumerilii" (THESIS/DISSERTATION)
1,2 (from 1 (best) to 6)
Affiliation

Science

Category
Host institution
Employer
2017/05/15 - Current Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2012/10/01 - 2017/05/14 Postdoc (Research) Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria
2007/11/15 - 2012/04/28 Researcher (Research) Cancer Research UK, London Research Institute, Clare Hall Laboratories, United Kingdom
2011/01/01 - 2011/03/31 Visiting Researcher (Research) Fondazione Istituto FIRC di Oncologia Molecolare, Italy
2007/01/01 - 2007/11/14 Research Trainee (Research) European Molecular Biology Laboratory, Germany
2006/01/01 - 2006/04/01 Visiting Researcher (Research) Columbia University College of Physicians and Surgeons, United States
2003/01/01 - 2006/01/01 Research Assistant (Research) Deutsches Krebsforschungszentrum, Germany
Projects

Grant

Designation Funders
2022/01/01 - 2023/01/07 Role of mitochondrial uncoupling in the pathogenesis of sepsis
EXPL/MED-OUT/0745/2021
Principal investigator
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/05 - 2017/05 A novel primary class switch recombination immunodeficiency
grant.M 1809
Awardee of Postdoctoral fellow salary and 40.000 € project/consumables grant
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria
FWF Austrian Science Fund
Concluded
2015 - 2017 Identification and molecular investigation of a novel primary immunodeficiency disorder caused by DNA polymerase deficiency
Co-coordinator of 193 000 € project grant
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria
Österreichische Nationalbank
Concluded

Contract

Designation Funders
2020/08/01 - Current Modulation of TNF receptor signalling by anthracyclines
CEECIND/02661/2018
FCT Investigator Salary Grant
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2022/01/01 - 2023/07/01 Role for histone eviction in the metabolic changes associated with sepsis
EXPL/MED-IMU/0620/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Willmann, Katharina; Kracker, Sven; Simon, Maria T.; Franchini, Don-Marc; Gardes, Pauline; Durandy, Anne; Petersen-Mahrt, Svend K.. "AID in Immunodeficiency and Cancer". In Molecular Medicine and Medicinal Chemistry, 152-186. IMPERIAL COLLEGE PRESS, 2010.
    10.1142/9781848165939_0008
Conference paper
  1. Willmann, Katharina. "ESID-0732 A Novel Primary Immunodeficiency Disorder with Multiple Defects of the Lymphoid System Caused by Perturbed NF-KAPPA B Signaling". Paper presented in ESID2014, Prag, 2014.
Conference poster
  1. Willmann, Katharina; Pauklin, S.; Milosevic, S.; Rangam, G.; Maslen, S.. "A role for the RNA pol II associated PAF complex in AID-induced immune diversification". Paper presented in 3rd EMBO meeting, 2011.
  2. Willmann, Katharina. "Interaction between AID and PCNA: A role in AID-induced immune diversification?". Paper presented in Cold Spring Harbor Asia Conference on Chromatin, Epigenetics and Transcription, 2010.
Journal article
  1. Willmann, Katharina; Moita, Luis F.. "Physiologic disruption and metabolic reprogramming in infection and sepsis". Cell Metabolism (2024): http://dx.doi.org/10.1016/j.cmet.2024.02.013.
    10.1016/j.cmet.2024.02.013
  2. Angelo Ferreira Chora; Dora Pedroso; Eleni Kyriakou; Nadja Pejanovic; Henrique. G. Colaço; Raffaella Gozzelino; André Barros; et al. "DNA damage independent inhibition of NF-¿B transcription by anthracyclines". eLife 11 (2022): http://dx.doi.org/10.7554/elife.77443.
    10.7554/elife.77443
  3. Velho, Tiago R.; Ferreira, Ricardo; Willmann, Katharina; Pedroso, Dora; Paixão, Tiago; Pereira, Rafael Maniés; Junqueira, Nádia; et al. "Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk". Critical Care Explorations 4 10 (2022): e0763. http://dx.doi.org/10.1097/cce.0000000000000763.
    10.1097/cce.0000000000000763
  4. Colaço, Henrique G.; Barros, André; Neves-Costa, Ana; Seixas, Elsa; Pedroso, Dora; Velho, Tiago; Willmann, Katharina L.; et al. "Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection". Immunity 54 1 (2021): 53-67.e7. http://dx.doi.org/10.1016/j.immuni.2020.09.011.
    Published • 10.1016/j.immuni.2020.09.011
  5. Conde, C.D.*; Petronczki, Ö. Y.*; Baris, S*; Willmann, K.L.*; Girardi, E.; Salzer, E.; Weitzer, S.; et al. "Polymerase d deficiency causes syndromic immunodeficiency with replicative stress". Journal of Clinical Investigation 129 10 (2019): 4194-4206. *equal contribution.
    Open access • Published • 10.1172/jci128903
  6. Astrid Fauster; Manuele Rebsamen; Katharina L. Willmann; Adrian César-Razquin; Enrico Girardi; Johannes W. Bigenzahn; Fiorella Schischlik; et al. "Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking". Cell Death & Differentiation (2018): https://doi.org/10.1038/s41418-018-0192-6.
    10.1038/s41418-018-0192-6
  7. Salzer, E.; Cagdas, D.; Hons, M.; MacE, E.M.; Garncarz, W.; Petronczki, Ö.Y.; Platzer, R.; et al. "RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics". Nature Immunology 17 12 (2016): 1352-1360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992410702&partnerID=MN8TOARS.
    10.1038/ni.3575
  8. Willmann, K.L.; Sacco, R.; Martins, R.; Garncarz, W.; Krolo, A.; Knapp, S.; Bennett, K.L.; Boztug, K.. "Expanding the Interactome of the Noncanonical NF-¿B Signaling Pathway". Journal of Proteome Research 15 9 (2016): 2900-2909. http://www.scopus.com/inward/record.url?eid=2-s2.0-84985996269&partnerID=MN8TOARS.
    10.1021/acs.jproteome.5b01004
  9. Willmann, K.L.; Klaver, S.; Do U, F.; Santos-Valente, E.; Garncarz, W.; Bilic, I.; Mace, E.; et al. "Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923384476&partnerID=MN8TOARS.
    10.1038/ncomms6360
  10. Willmann, K.L.; Milosevic, S.; Pauklin, S.; Schmitz, K.-M.; Rangam, G.; Simon, M.T.; Maslen, S.; et al. "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification". Journal of Experimental Medicine 209 11 (2012): 2099-2111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870204989&partnerID=MN8TOARS.
    10.1084/jem.20112145
Thesis / Dissertation
  1. Willmann, Katharina. "Investigation of transcriptional targeting and DNA lesion resolution of Activation Induced Deaminase by cofactor analysis". PhD, University College London Faculty of Life Sciences, 2012. https://discovery.ucl.ac.uk/id/eprint/1352786.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/15 Role of mitochondrial uncoupling in sepsis 2nd Mitochondria Conference
Fusion (Lisbon, Portugal)
2015/09/06 A novel primary immunodeficiency disorder with multiple defects of the lymphoid system caused by biallelic loss-of-function mutation in affecting the NF-kB inducing kinase NIK. 4th European Congress for Immunology (ECI)
(Vienna, Austria)
2014/10/30 A Novel Primary Immunodeficiency Disorder with Multiple Defects of the Lymphoid System Caused by Perturbed NF-KAPPA B Signaling. 16th Biennial ESID Meeting.
European Society for Immunodeficiencies (ESID) (Prague, Czech Republic)
2014/09/19 Identification of a novel primary immunodeficiency disorder with multiple defects of the lymphoid system caused by perturbed NF-kB Signaling. 52nd Annual Meeting of the Austrian Society for Pediatrics
Österreichische Gesellschaft für Kinder- und Jugendheilkune (Vienna, Austria)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2016 - 2017 Primary Immunodeficiencies with Autoimmunity
Co-supervisor
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria

Medizinische Universität Wien, Austria
2014 - 2017 Primary Immunodeficiencies with early onset inflammatory bowel disease
Co-supervisor
CCHD (Cell Communication in Health and Disease) (PhD)
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria

Medizinische Universität Wien, Austria

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022/01/01 - 2022/10/30 Organization of Conference 3C-Cells, Computers and Clinics - A transdisciplinary symposium towards understanding human health (2022/10/28 - 2022/10/30)
Conference (Member of the Organising Committee)
Instituto Gulbenkian de Ciência, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/02/17 - 2022/02/17 Course Participation - Rodent Pathology Necropsy Course
CONGENTO, Portugal
2020/11 - 2020/11 Course Participation: Experimental Design and Project Design in preclinical research (DGAV personal license)
Workshop
CONGENTO Upgrade to EU Function B
Fundação Champalimaud, Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2019/11/04 - 2019/11/07 Course Participation - Integrative Biological Interpretation using Proteomics
Workshop
IBIP2019
Instituto Gulbenkian de Ciência, Portugal

Gulbenkian Training Programme in Bioinformatics, Portugal
2017/11 - 2017/11 Course Participation: Animal Handling and Experimentation IGC/SPCAL (DGAV personal license)
Workshop
EU Functions A and D
Instituto Gulbenkian de Ciência, Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2017/02/28 - 2017/02/28 Patient Engagement, Round Table and Sports Event
Festival
Rare Disease Day
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Austria
2010 - 2010 Fundraising Event Speaker (CRUK Legacies)
Meeting
Cancer Research UK, London Research Institute, United Kingdom

Association member

Society Organization name Role
2023/01 - Current SPI | Sociedade Portuguesa de Imunologia | Portuguese Immunology Society Member
2013 - Current European Society for Immunodeficiencies (ESID) Member
2013 - 2022/12 Austrian Society for Allergology and Immunology (ÖGAI) Member

Committee member

Activity description
Role
Institution / Organization
2019/11 - Current 'Sustainable IGC' co-founder and comittee member
Member
Instituto Gulbenkian de Ciência, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/11 - 2023/11 Guest Lecturer Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2017 PhD Course Tutor, 1 lecture/practical course (8h) per year. Cell Communication in Health and Disease (CCHD) PhD program (Doktor (PhD)) Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria

Medizinische Universität Wien, Austria

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2024/01 - 2034/01 Reviewer for APVV 2023 VV call (Slovak Research and Development Agency)
Evaluator
Agentúra na podporu výskumu a vývoja Slovenskej republiky, Slovakia Agentúra na podporu výskumu a vývoja Slovenskej republiky

Journal scientific committee

Journal title (ISSN) Publisher
2017 - 2025/01 Reviewer - Frontiers in Immunology (1664-3224) Frontiers Media SA
2022/04 - 2022/04 Reviewer - Journal of Clinical Immunology (0271-9142) Springer

Mentoring / Tutoring

Topic Student name
2022/06/13 - 2023/01/12 Undergraduate student supervision Vicente Mateus
2016/10 - 2016/11 Rotation student supervision Fangwen Zhao
Distinctions

Award

2014 Best Abstract Award, Annual meeting of the Austrian Society for Pediatrics (ÖGKJ)
Austrian Pediatric Society (Österreichische Gesellschaft für Kinder- und Jugendheilkunde, ÖGKJ), Austria
2011 EMBO Journal poster prize, EMBO Meeting, Vienna, Austria
EMBO Journal, Germany

Other distinction

2022 Honorable mention - Project "Pharmacological targeting of the mitochondrial function for sepsis treatment"
Maratona da Saúde, Portugal
2017 MSCA Seal of Excellence
European Commission, Belgium
2012 Group Winner in the MedImmune Drug Discovery workshop challenge, NatureJobs Career Expo
AstraZeneca Medimmune, United Kingdom
2010 CoB Travel Grant
Society for Experimental Biology, United Kingdom