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Katharina Willmann graduated in Biology at Heidelberg University (Germany) and holds a Ph.D. in Molecular Immunology awarded by UCL (London, UK) in 2012. Katharina has 14 years of pre- and post-doctoral international research experience in immunology and molecular medicine, in Germany, UK, Austria & Portugal. Her research interests developed from biochemistry of antibody diversification over human immunology towards systems biology of inflammatory diseases. Katharina's PhD work at CRUK London Research Institute has led to new insights on the enzyme Activation Induced Deaminase (AID) in Antibody Diversification (1 resulting first-author peer-reviewed publication, 1 book chapter). In her postdoctoral work at CeMM, Vienna, she worked on the molecular mechanisms of Primary Immunodeficiencies, studying hitherto uncharacterized rare patients by human genetics, immunological and biochemical methods (2 resulting first author and 1 co-author peer-reviewed publications). She also developed systematic approaches to immune disorders using proteomics, haploid and CRISPR/Cas9 forward genetic screens (1 resulting first author and 1 co-author peer-reviewed publications). At Instituto Gulbenkian de Ciência (IGC), Portugal, she studies tissue damage control/disease tolerance pathways with L. Moita, MD PhD (1 resulting first author and 3 resulting co-author peer reviewed publication). She was awarded a Portuguese FCT CEEC individual researcher position to study the role of candidate molecular mediators of cytoprotection, and an Exploratory Research Grant from FCT to study mitochondrial uncoupling in the pathogenesis of sepsis. Overall, since obtaining her University degree, she has published 10 papers in international peer-reviewed journals with an accumulated IF of 93 (Web of Science) and with 498 citations; h-index=7 (Google Scholar). Of these, 5 were published as first author (2012-2024), and 8 were published in the top 9% journals in their research field. She is certified by DGAV to work with animal models and to coordinate preclinical animal projects. Until present, she has co-supervised 2 PhD students, taught in 1 PhD program course, served as invited reviewer for 2 Journals, is organizer of 1 scientific conference, and initiated several interdisciplinary collaborations (Proteomics: André Müller, Head of Proteomics and Metabolomics, CeMM, Vienna; Genetic DNA instability disorders: Dr. Joanna Loizou, Medical University Vienna, Clinical: Prof. Pedro Póvoa, CHRC, HSFX, Lisbon). Throughout her career, she was recognised with a Cancer Research UK predoctoral fellowship, an Austrian FWF Lise Meitner Individual Post-doctoral Fellowship, and secured 1 research grant as PI (funded by FCT) and 1 as co-Investigator funded by the Austrian OeNB. Moreover, she was selected to talk at 1 national and 2 international scientific meetings and obtained 3 conference prizes.
Identificação

Identificação pessoal

Nome completo
Katharina Laura Willmann

Nomes de citação

  • Willmann, Katharina

Identificadores de autor

Ciência ID
981B-0B1A-2044

Moradas

  • IGC Instituto Gulbenkian de Ciência. RUA DA QUINTA GRANDE, 6, 2780-156, OEIRAS, Oeiras, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1)
Francês Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A1)
Português Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2) Utilizador elementar (A1)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/11/15 - 2012/04/28
Concluído
Cancer Research UK London Research Institute PhD programme (Doctor of Philosophy)
Especialização em Molecular Immunology
University College London Faculty of Life Sciences, Reino Unido
"Regulation of Activation Induced Cytosine Deaminase: analysis of cofactors for transcriptional targeting and DNA lesion resolution" (TESE/DISSERTAÇÃO)
N/A
2002 - 2007/10/31
Concluído
Diplom Biologie (Master)
Especialização em Molecular Biology
Ruprecht Karls Universität Heidelberg, Alemanha
"Exploring phylogenetic footprinting in the polychaete Platynereis dumerilii" (TESE/DISSERTAÇÃO)
1,2 (from 1 (best) to 6)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2017/05/15 - Atual Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2012/10/01 - 2017/05/14 Pós-doutorado (Investigação) Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria
2007/11/15 - 2012/04/28 Investigador (Investigação) Cancer Research UK, London Research Institute, Clare Hall Laboratories, Reino Unido
2011/01/01 - 2011/03/31 Investigador visitante (Investigação) Fondazione Istituto FIRC di Oncologia Molecolare, Itália
2007/01/01 - 2007/11/14 Estagiário de Investigação (Investigação) European Molecular Biology Laboratory, Alemanha
2006/01/01 - 2006/04/01 Investigador visitante (Investigação) Columbia University College of Physicians and Surgeons, Estados Unidos
2003/01/01 - 2006/01/01 Assistente de Investigação (carreira) (Investigação) Deutsches Krebsforschungszentrum, Alemanha
Projetos

Bolsa

Designação Financiadores
2022/01/01 - 2023/01/07 Role of mitochondrial uncoupling in the pathogenesis of sepsis
EXPL/MED-OUT/0745/2021
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2015/05 - 2017/05 A novel primary class switch recombination immunodeficiency
grant.M 1809
Awardee of Postdoctoral fellow salary and 40.000 € project/consumables grant
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria
FWF Austrian Science Fund
Concluído
2015 - 2017 Identification and molecular investigation of a novel primary immunodeficiency disorder caused by DNA polymerase deficiency
Co-coordinator of 193 000 € project grant
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria
Österreichische Nationalbank
Concluído

Projeto

Designação Financiadores
2020/08/01 - Atual Modulation of TNF receptor signalling by anthracyclines
CEECIND/02661/2018
FCT Investigator Salary Grant
Instituto Gulbenkian de Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designação Financiadores
2022/01/01 - 2023/07/01 Role for histone eviction in the metabolic changes associated with sepsis
EXPL/MED-IMU/0620/2021
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em conferência
  1. Willmann, Katharina. "ESID-0732 A Novel Primary Immunodeficiency Disorder with Multiple Defects of the Lymphoid System Caused by Perturbed NF-KAPPA B Signaling". Trabalho apresentado em ESID2014, Prag, 2014.
Artigo em revista
  1. Willmann, Katharina; Moita, Luis F.. "Physiologic disruption and metabolic reprogramming in infection and sepsis". Cell Metabolism (2024): http://dx.doi.org/10.1016/j.cmet.2024.02.013.
    10.1016/j.cmet.2024.02.013
  2. Angelo Ferreira Chora; Dora Pedroso; Eleni Kyriakou; Nadja Pejanovic; Henrique. G. Colaço; Raffaella Gozzelino; André Barros; et al. "DNA damage independent inhibition of NF-¿B transcription by anthracyclines". eLife 11 (2022): http://dx.doi.org/10.7554/elife.77443.
    10.7554/elife.77443
  3. Velho, Tiago R.; Ferreira, Ricardo; Willmann, Katharina; Pedroso, Dora; Paixão, Tiago; Pereira, Rafael Maniés; Junqueira, Nádia; et al. "Role of Omega-6 Fatty Acid Metabolism in Cardiac Surgery Postoperative Bleeding Risk". Critical Care Explorations 4 10 (2022): e0763. http://dx.doi.org/10.1097/cce.0000000000000763.
    10.1097/cce.0000000000000763
  4. Colaço, Henrique G.; Barros, André; Neves-Costa, Ana; Seixas, Elsa; Pedroso, Dora; Velho, Tiago; Willmann, Katharina L.; et al. "Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection". Immunity 54 1 (2021): 53-67.e7. http://dx.doi.org/10.1016/j.immuni.2020.09.011.
    Publicado • 10.1016/j.immuni.2020.09.011
  5. Conde, C.D.*; Petronczki, Ö. Y.*; Baris, S*; Willmann, K.L.*; Girardi, E.; Salzer, E.; Weitzer, S.; et al. "Polymerase d deficiency causes syndromic immunodeficiency with replicative stress". Journal of Clinical Investigation 129 10 (2019): 4194-4206. *equal contribution.
    Acesso aberto • Publicado • 10.1172/jci128903
  6. Astrid Fauster; Manuele Rebsamen; Katharina L. Willmann; Adrian César-Razquin; Enrico Girardi; Johannes W. Bigenzahn; Fiorella Schischlik; et al. "Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking". Cell Death & Differentiation (2018): https://doi.org/10.1038/s41418-018-0192-6.
    10.1038/s41418-018-0192-6
  7. Salzer, E.; Cagdas, D.; Hons, M.; MacE, E.M.; Garncarz, W.; Petronczki, Ö.Y.; Platzer, R.; et al. "RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics". Nature Immunology 17 12 (2016): 1352-1360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992410702&partnerID=MN8TOARS.
    10.1038/ni.3575
  8. Willmann, K.L.; Sacco, R.; Martins, R.; Garncarz, W.; Krolo, A.; Knapp, S.; Bennett, K.L.; Boztug, K.. "Expanding the Interactome of the Noncanonical NF-¿B Signaling Pathway". Journal of Proteome Research 15 9 (2016): 2900-2909. http://www.scopus.com/inward/record.url?eid=2-s2.0-84985996269&partnerID=MN8TOARS.
    10.1021/acs.jproteome.5b01004
  9. Willmann, K.L.; Klaver, S.; Do U, F.; Santos-Valente, E.; Garncarz, W.; Bilic, I.; Mace, E.; et al. "Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923384476&partnerID=MN8TOARS.
    10.1038/ncomms6360
  10. Willmann, K.L.; Milosevic, S.; Pauklin, S.; Schmitz, K.-M.; Rangam, G.; Simon, M.T.; Maslen, S.; et al. "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification". Journal of Experimental Medicine 209 11 (2012): 2099-2111. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870204989&partnerID=MN8TOARS.
    10.1084/jem.20112145
Capítulo de livro
  1. Willmann, Katharina; Kracker, Sven; Simon, Maria T.; Franchini, Don-Marc; Gardes, Pauline; Durandy, Anne; Petersen-Mahrt, Svend K.. "AID in Immunodeficiency and Cancer". In Molecular Medicine and Medicinal Chemistry, 152-186. IMPERIAL COLLEGE PRESS, 2010.
    10.1142/9781848165939_0008
Poster em conferência
  1. Willmann, Katharina; Pauklin, S.; Milosevic, S.; Rangam, G.; Maslen, S.. "A role for the RNA pol II associated PAF complex in AID-induced immune diversification". Trabalho apresentado em 3rd EMBO meeting, 2011.
  2. Willmann, Katharina. "Interaction between AID and PCNA: A role in AID-induced immune diversification?". Trabalho apresentado em Cold Spring Harbor Asia Conference on Chromatin, Epigenetics and Transcription, 2010.
Tese / Dissertação
  1. Willmann, Katharina. "Investigation of transcriptional targeting and DNA lesion resolution of Activation Induced Deaminase by cofactor analysis". Doutoramento, University College London Faculty of Life Sciences, 2012. https://discovery.ucl.ac.uk/id/eprint/1352786.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/07/15 Role of mitochondrial uncoupling in sepsis 2nd Mitochondria Conference
Fusion (Lisbon, Portugal)
2015/09/06 A novel primary immunodeficiency disorder with multiple defects of the lymphoid system caused by biallelic loss-of-function mutation in affecting the NF-kB inducing kinase NIK. 4th European Congress for Immunology (ECI)
(Vienna, Áustria)
2014/10/30 A Novel Primary Immunodeficiency Disorder with Multiple Defects of the Lymphoid System Caused by Perturbed NF-KAPPA B Signaling. 16th Biennial ESID Meeting.
European Society for Immunodeficiencies (ESID) (Prague, República Checa)
2014/09/19 Identification of a novel primary immunodeficiency disorder with multiple defects of the lymphoid system caused by perturbed NF-kB Signaling. 52nd Annual Meeting of the Austrian Society for Pediatrics
Österreichische Gesellschaft für Kinder- und Jugendheilkune (Vienna, Áustria)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2016 - 2017 Primary Immunodeficiencies with Autoimmunity
Coorientador
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria

Medizinische Universität Wien, Áustria
2014 - 2017 Primary Immunodeficiencies with early onset inflammatory bowel disease
Coorientador
CCHD (Cell Communication in Health and Disease) (Doutoramento)
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria

Medizinische Universität Wien, Áustria

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022/01/01 - 2022/10/30 Organization of Conference 3C-Cells, Computers and Clinics - A transdisciplinary symposium towards understanding human health (2022/10/28 - 2022/10/30)
Conferência (Membro da Comissão Organizadora)
Instituto Gulbenkian de Ciência, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2022/02/17 - 2022/02/17 Course Participation - Rodent Pathology Necropsy Course
CONGENTO, Portugal
2020/11 - 2020/11 Course Participation: Experimental Design and Project Design in preclinical research (DGAV personal license)
Oficina (workshop)
CONGENTO Upgrade to EU Function B
Fundação Champalimaud, Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2019/11/04 - 2019/11/07 Course Participation - Integrative Biological Interpretation using Proteomics
Oficina (workshop)
IBIP2019
Instituto Gulbenkian de Ciência, Portugal

Gulbenkian Training Programme in Bioinformatics, Portugal
2017/11 - 2017/11 Course Participation: Animal Handling and Experimentation IGC/SPCAL (DGAV personal license)
Oficina (workshop)
EU Functions A and D
Instituto Gulbenkian de Ciência, Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2017/02/28 - 2017/02/28 Patient Engagement, Round Table and Sports Event
Festival
Rare Disease Day
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Áustria
2010 - 2010 Fundraising Event Speaker (CRUK Legacies)
Encontro
Cancer Research UK, London Research Institute, Reino Unido

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2017 - 2025/01 Reviewer - Frontiers in Immunology (1664-3224) Frontiers Media SA
2022/04 - 2022/04 Reviewer - Journal of Clinical Immunology (0271-9142) Springer

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2024/01 - 2034/01 Reviewer for APVV 2023 VV call (Slovak Research and Development Agency)
Avaliador
Agentúra na podporu výskumu a vývoja Slovenskej republiky, Eslováquia Agentúra na podporu výskumu a vývoja Slovenskej republiky

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/11 - 2023/11 Guest Lecturer Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2017 PhD Course Tutor, 1 lecture/practical course (8h) per year. Cell Communication in Health and Disease (CCHD) PhD program (Doktor (PhD)) Research Center for Molecular Medicine of the Austrian Academy of Sciences, Áustria

Medizinische Universität Wien, Áustria

Membro de associação

Nome da associação Tipo de participação
2023/01 - Atual SPI | Sociedade Portuguesa de Imunologia | Portuguese Immunology Society Member
2013 - Atual European Society for Immunodeficiencies (ESID) Member
2013 - 2022/12 Austrian Society for Allergology and Immunology (ÖGAI) Member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2019/11 - Atual 'Sustainable IGC' co-founder and comittee member
Membro
Instituto Gulbenkian de Ciência, Portugal

Tutoria

Tópico Nome do aluno
2022/06/13 - 2023/01/12 Undergraduate student supervision Vicente Mateus
2016/10 - 2016/11 Rotation student supervision Fangwen Zhao
Distinções

Prémio

2014 Best Abstract Award, Annual meeting of the Austrian Society for Pediatrics (ÖGKJ)
Austrian Pediatric Society (Österreichische Gesellschaft für Kinder- und Jugendheilkunde, ÖGKJ), Áustria
2011 EMBO Journal poster prize, EMBO Meeting, Vienna, Austria
EMBO Journal, Alemanha

Outra distinção

2022 Honorable mention - Project "Pharmacological targeting of the mitochondrial function for sepsis treatment"
Maratona da Saúde, Portugal
2017 MSCA Seal of Excellence
European Commission, Bélgica
2012 Group Winner in the MedImmune Drug Discovery workshop challenge, NatureJobs Career Expo
AstraZeneca Medimmune, Reino Unido
2010 CoB Travel Grant
Society for Experimental Biology, Reino Unido