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Carmen de Sena Tomás obtained her degree in Biology from the Universidad de Salamanca, Spain in 2006. Then, she moved to the Centro Nacional de Biotecnología (CNB-CSIC) in Madrid where she performed her PhD sutdies under the supervision of Prof. Dr. José Pérez-Martín. During her PhD, she demonstrated how in absence of DNA damage, the DNA damage response pathway (Atr1/Chk1) controls cell cycle progression in dikaryons, an essential cellular stage in the life cycle of most Basidiomycetes. In addition she characterized the role of Ku proteins which play and essential role in the telomeres to avoid unwanted recombination in U. maydis. After earning her PhD degree in 2012, she performed a first postdoc on genome stability in Prof. Dr. William K. Holloman's lab at Cornell University (New York, USA), where she showed the role of a LAMMER kinase in cell cycle regulation and chromosome segregation during meiosis in U. maydis. Subsequently, she joined Dr. Kimara Targoff’s lab at Columbia University (New York, USA) to study heart development and regeneration in zebrafish. During this second postdoc, she demonstrated a previously unrecognized Nkx2.5-dependent regenerative circuit that invokes myocardial proliferation and dedifferentiation to ensure effective regeneration in the zebrafish heart. Currently, she works as a senior postdoctoral researcher in Dr. Leonor Saúde's lab at Instituto de Medicina Molecular (IMM-JLA) in Lisboa, studying the role of the immune system in spinal cord regeneration in zebrafish. She has participated in international collaborations and published several research articles in international peer-reviewed Q1 journals and attended international epecialized conferences where her work has been recognized.
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Identification

Personal identification

Full name
Carmen De Sena Tomas

Citation names

  • de Sena-Tomás, Carmen

Author identifiers

Ciência ID
9C19-402D-4AAA
ORCID iD
0000-0002-0477-6135

Email addresses

  • cdesena@medicina.ulisboa.pt (Professional)

Addresses

  • Avenida Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Plant sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/09/01 - 2012/03/02
Concluded
 Molecular Biology (Doutoramento)
Universidad Autónoma de Madrid, Spain
"Roles of the Atr1-Chk1 pathway in the phytopathogenic fungus Ustilago maydis" (THESIS/DISSERTATION)
 sobresaliente cum laude
2007 - 2009
Concluded
 Molecular Biology (DEA)
Universidad Autónoma de Madrid, Spain
"Characterization of atr1 in Ustilago maydis" (THESIS/DISSERTATION)
2001/09/01 - 2006/10/05
Concluded
 Biology (Licence)
Universidad de Salamanca Facultad de Biología, Spain
"Molecular analysis of the regulation of fas gene expression in Rhodococcus fascians" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2019/02/01 - Current Postdoc (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2015/01/05 - 2018/12/31 Postdoc (Research) Columbia University, United States
Columbia University, United States
2012/06/01 - 2015/01/04 Postdoc (Research) Weill Cornell Medicine, United States
Weill Cornell Medicine, United States
2011/04/01 - 2011/06/30 Research Trainee (Research) Georg August Universität Büsgen Institut, Germany
2010/05/01 - 2010/07/31 Research Trainee (Research) Georg August Universität Büsgen Institut, Germany
2008/09/12 - 2008/12/12 Research Trainee (Research) Weill Cornell Medicine, United States
2005/09/30 - 2006/07/01 Research Trainee (Research) Vlaams Instituut voor Biotechnologie Department of Plant Systems Biology, Belgium

Others

Category
Host institution 		Employer
2007/09/01 - 2012/02/28 PhD student Centro Nacional de Biotecnología, Spain
Projects

Grant

Designation Funders
2022/01/01 - Current Improving spinal cord regeneration by modulating neutrophil inflammation: lessons from a zebrafish perspective
2022.02766.PTDC
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2018/12/31 Mechanisms of the second heart field development regulated by Nkx genes
1R01HL131438-01A1
Post-doc
Columbia University, United States
 National Institute of Health (NIH), National Heart, Lung and Blood Institute (NHLBI)
Ongoing

Contract

Designation Funders
2019/02/01 - Current Modulation of vascular repair during spinal cord regeneration
PTDC/BIA-BID/28572/2017
Post-doc
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2023/08/31 Senescent cells and their secretory phenotype: novel targets for spinal cord repair
MC36-2020
Post-doc
Instituto de Medicina Molecular, Portugal
 Santa Casa da Misericórdia de Lisboa
Ongoing
2019/09/15 - 2023/03/14 Targeting induced-senescent cells: a novel approach to promote spinal cord regeneration in mammals
HR18-00187
Research Fellow
Instituto de Medicina Molecular, Portugal
 Obra Social La Caixa
Concluded
2014/07/01 - 2015/01/04 Mechanisms in Brh2-promoted recombinational repair
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES/5R01GM079859-06/US
Post-doc
Weill Cornell Medicine, United States
 National Institutes of Health
Concluded
2012/06/01 - 2014/06/30 BRCA2 model system
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES/5R01GM042482-19/US
Post-doc
Weill Cornell Medicine, United States
 National Institutes of Health
Concluded
2007/09/01 - 2011/08/31 Analysis of the formation of the infective filament of Ustilago maydis: a model to define cell cycle regulators and morphogenesis regulators as virulence factors in pathogenic fungi
BIO2005-02998
PhD Student Fellow
Centro Nacional de Biotecnología, Spain
 Ministerio de Educación y Ciencia
Concluded
Outputs

Publications

Conference poster
  1. Ford, Caitlin; de Sena-Tomás, Carmen; Gao, Cynthia; Rangaswami, Uday; See, Michael; Nim, Hieu; Sanges, Remo; Ramialison, Mirana; Targoff, Kimara L.. "Nkx2.7 is a novel regulator of pharyngeal arch development". Paper presented in Weinstein Cardiovascular Development and Regeneration Meeting, 2022.
  2. Yao, Di; Aleman, Angelika G.; Ford, Caitlin; Woodard, Micah; de Sena-Tomás, Carmen; Targoff, Kimara L.. "Fibulin genes regulate outflow track caliber and extracellular matrix integrity". Paper presented in Weinstein Cardiovascular Development and Regeneration Meeting, 2022.
  3. Neves-Silva, Dalila; Martins, Isaura; de Sena-Tomás, Carmen; Rebocho da Costa, Mariana; Quitéria, Raquel; Matthiesen, Rune; Carvalho, A. S.; et al. "Mimicking the Zebrafish Extracellular Matrix Profile in Mammals to Promote Spinal Cord Repair.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN2021), 2021.
  4. de Sena-Tomás, Carmen; Yao, Di; Aleman, Angelika G.; Harrington, Jamie; Varshney, Akriti; Saúde, Leonor; Ramialison, Mirana; Targoff, Kimara L.. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair". Paper presented in 16th International Zebrafish Conference, 2021.
  5. Ribeiro, Ana; Rebocho da Costa, Mariana; de Sena-Tomás, Carmen; Saúde, Leonor. "Vascular repair after spinal cord injury in zebrafish". Paper presented in 16th International Zebrafish Conference, 2021.
  6. Ford, Caitlin; de Sena-Tomás, Carmen; Targoff, Kimara L.. "Nkx2.7 is a novel regulator of craniofacial muscle and cartilage development". Paper presented in 16th International Zebrafish Conference, 2021.
  7. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation and extracellular matrix patterning during myocardial repair". Paper presented in Weinstein Cardiovascular Development and Regeneration Conference, 2018.
  8. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation during myocardial repair". Paper presented in Weinstein Cardiovascular Development and Regeneration Meeting, 2017.
  9. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation during ventricular regeneration". Paper presented in Weinstein Cardiovascular Development and Regeneration Conference, 2016.
  10. de Sena-Tomás, Carmen; Pérez-Martín, José. "Essentiality of Ku70/80 in Ustilago maydis is related to its ability to suppress DNA damage signaling at telomeres". Paper presented in UNIA workshop “The enemy within: endogenous DNA damage as a source of cancer and ageing”, 2011.
  11. de Sena-Tomás, Carmen; Pérez-Martín, José. "Ku70/80 avoid DNA damage checkpoint activation at telomeres in Ustilago maydis". Paper presented in EMBO workshop “Chromosome structure, damage & repair”, 2011.
Journal article
  1. de Sena-Tomás, Carmen; Aleman, Angelika G.; Ford, Caitlin; Varshney, Akriti; Yao, Di; Harrington, Jamie K.; Saúde, Leonor; Ramialison, Mirana; Targoff, Kimara L.. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-30468-4.
    10.1038/s41467-022-30468-4
  2. Budine, Terin E.; de Sena-Tomás, Carmen; Williams, Margot L.K.; Sepich, Diane S.; Targoff, Kimara L.; Solnica-Krezel, Lila. "Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development". Developmental Biology 462 2 (2020): 223-234. http://dx.doi.org/10.1016/j.ydbio.2020.03.002.
    Published • 10.1016/j.ydbio.2020.03.002
  3. Morikawa, Kumi; Furuhashi, Kazuhiro; de Sena-Tomás, Carmen; Garcia-Garcia, Alvaro L.; Bekdash, Ramsey; Klein, Alison D.; Gallerani, Nicholas; et al. "Photoactivatable Cre recombinase 3.0 for in vivo mouse applications". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16030-0.
    Published • 10.1038/s41467-020-16030-0
  4. Shi, Lingyan; Zheng, Chaogu; Shen, Yihui; Chen, Zhixing; Silveira, Edilson S.; Zhang, Luyuan; Wei, Mian; et al. "Optical imaging of metabolic dynamics in animals". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05401-3.
    Published • 10.1038/s41467-018-05401-3
  5. Colombo, Sophie; de Sena-Tomás, Carmen; George, Vanessa; Werdich, Andreas A.; Kapur, Sunil; MacRae, Calum A.; Targoff, Kimara L.. "Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression". Development 145 3 (2017): dev161497. http://dx.doi.org/10.1242/dev.161497.
    Published • 10.1242/dev.161497
  6. Tenorio-Gómez, María; de Sena-Tomás, Carmen; Pérez-Martín, Jose. "MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis". PLOS ONE 10 9 (2015): e0137192. http://dx.doi.org/10.1371/journal.pone.0137192.
    Published • 10.1371/journal.pone.0137192
  7. de Sena-Tomás, Carmen; Sutherland, Jeanette H.; Milisavljevic, Mira; Nikolic, Dragana B.; Pérez-Martín, José; Kojic, Milorad; Holloman, William K.. "LAMMER kinase contributes to genome stability in Ustilago maydis". DNA Repair 33 (2015): 70-77. http://dx.doi.org/10.1016/j.dnarep.2015.05.011.
    Published • 10.1016/j.dnarep.2015.05.011
  8. de Sena-Tomás, Carmen; Yu, Eun Young; Calzada, Arturo; Holloman, William K.; Lue, Neal F.; Pérez-Martín, José. "Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres". Nucleic Acids Research 43 4 (2015): 2138-2151. http://dx.doi.org/10.1093/nar/gkv082.
    Published • 10.1093/nar/gkv082
  9. de Sena-Tomás, Carmen; Navarro-González, Mónica; Kües, Ursula; Pérez-Martín, José. "A DNA Damage Checkpoint Pathway Coordinates the Division of Dikaryotic Cells in the Ink Cap Mushroom Coprinopsis cinerea". Genetics 195 1 (2013): 47-57. http://dx.doi.org/10.1534/genetics.113.152231.
    Published • 10.1534/genetics.113.152231
  10. Pérez-Martín, Jose; de Sena-Tomás, Carmen. "Dikaryotic cell cycle in the phytopathogenic fungusUstilago maydisis controlled by the DNA damage response cascade". Plant Signaling & Behavior 6 10 (2011): 1574-1577. http://dx.doi.org/10.4161/psb.6.10.17055.
    Published • 10.4161/psb.6.10.17055
  11. de Sena-Tomás, Carmen; Fernández-Álvarez, Alfonso; Holloman, William K.; Pérez-Martín, José. "The DNA Damage Response Signaling Cascade Regulates Proliferation of the Phytopathogenic Fungus Ustilago maydis in Planta". The Plant Cell 23 4 (2011): 1654-1665. http://dx.doi.org/10.1105/tpc.110.082552.
    Published • 10.1105/tpc.110.082552
Preprint
  1. Ana Ribeiro; Mariana Rebocho da Costa; Carmen de Sena-Tomás; Elsa Charas Rodrigues; Raquel Quitéria; Tiago Maçarico; Susana Constantino Rosa Santos; Leonor Saúde. "New functional vessels form after spinal cord injury in zebrafish". 2022. https://doi.org/10.1101/2022.06.09.495446.
    10.1101/2022.06.09.495446
Thesis / Dissertation
  1. "Roles of the Atr1-Chk1 pathway in the phytopathogenic fungus Ustilago maydis". PhD, Universidad Autónoma de Madrid, 2012.
  2. "Characterization of atr1 in Ustilago maydis". Master, Universidad Autónoma de Madrid, 2009.
  3. "Molecular analysis of the regulation of fas gene expression in Rhodococcus fascians". Degree, Universidad de Salamanca, 2006.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/09/22 Nkx2.5 is required for proliferation during myocardial repair 2017 Fall MARZ (Mid Atlantic Region Zebrafish) meeting
NYU Langone Medical Center (New York, United States)
2010/09 Atr1, a DNA damage response kinase and its role in virulence in Ustilago maydis ZYMOMADRID XXIV
Universidad Complutense de Madrid (Madrid, Spain)
2008/02 Implication of the DNA damage response pathway in the virulence program of the phytopathogen Ustilago maydis ZYMOMADRID XXII
Universidad Complutense de Madrid (Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/09 - 2022/01 Unraveling the role of neutrophils during spinal cord regeneration in zebrafish
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/10 - 2018/10 Welcusa NY (networking) (2018/10 - 2018/10)
Other (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2018/08 - 2018/08 Epigenetics in health and disease and discussion on the future of biomedicine in Europe and Spain by Manel Esteller (2018/08 - 2018/08)
Seminar (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2018/06 - 2018/06 How to discover a new particle? Chasing Higgs Boson by Javier Santaolalla (2018/06 - 2018/06)
Other (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2018/05 - 2018/05 ECUSA-NY, 3rd anniversary science fair and networking event (2018/05 - 2018/05)
Other (President of the Organising Committee)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2018/03 - 2018/03 "Champions of illusion" by Stephen Macknik and Susana Martínez-Conde. Book presentation (2018/03 - 2018/03)
Other (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2018/02 - 2018/02 The challenges of a scientific career inside academia (2018/02 - 2018/02)
Round table (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2017/10 - 2017/10 Welcusa NY (networking) (2017/10 - 2017/10)
Other (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2017/05 - 2017/05 Immigration info session (2017/05 - 2017/05)
Round table (Member of the Organising Committee)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2016/10 - 2016/10 Alternatives for Science professionals to return to Spain (2016/10 - 2016/10)
Round table (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2016/09 - 2016/09 Welcusa NY (networking) (2016/09 - 2016/09)
Other (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States
2015/11 - 2015/11 Taxation for Spanish Scientists in the USA (2015/11)
Round table (Co-organisor)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), United States

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/06 - 2021/06 Participation at the 16th International Zebrafish Conference
Conference
 16th International Zebrafish Conference
2020/03/02 - 2020/03/06 Participation in the workshop "Recent Trends in CNS Regenerative Medicine: from injury and disease to advanced therapies"
Workshop
 Recent Trends in CNS Regenerative Medicine: from injury and disease to advanced therapies
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/05/16 - 2018/05/18 Participation in Weinstein Cardiovascular Development and Regeneration Conference 2018
Conference
 Weinstein Cardiovascular Development and Regeneration Conference
Weinstein Cardiovascular Development Conference, United States
2017/05/04 - 2017/05/06 Participation in Weinstein Cardiovascular Development and Regeneration Meeting 2017
Conference
 Weinstein Cardiovascular Development and Regeneration Meeting
Weinstein Cardiovascular Development Conference, United States
2016/05/19 - 2016/05/21 Participation in Weinstein Cardiovascular Development and Regeneration Conference 2016
Conference
 Weinstein Cardiovascular Development and Regeneration Conference
Weinstein Cardiovascular Development Conference, United States
2011/11/17 - 2011/11/19 Participation in UNIA workshop "The enemy within: endogenous DNA damage as a source of cancer and aging"
Workshop
 The enemy within: endogenous DNA damage as a source of cancer and ageing
Universidad Internacional de Andalucía, Spain
2011/09/25 - 2011/09/28 Participation in EMBO workshop "Chromosome structure, damage & repair"
Workshop
 Chromosome structure, damage & repair
EMBO Press, Germany

Association member

Society Organization name Role
2021/04 - Current International Zebrafish Society
2021/03/09 - Current International Society for Regenerative Biology Postdoctoral Member
2017/01 - 2018/12 ECUSA - NY (Spanish Scientists in the USA) President
2014/12 - 2017/01 ECUSA-NY (Spanish Scientists in the USA, New York Chapter) Founding member of ECUSA-NY and board member
2014/12 - 2017/01 ECUSA (Spanish Scientists in the USA) Advisory director
Distinctions

Award

2022 Travel award
Weinstein Cardiovascular Development Conference, United States
2017 Honorable mention award
Weinstein Cardiovascular Development Conference, United States

Other distinction

2007 PhD fellowship grant - BES-2007-16813
Ministerio de Educación y Ciencia, Spain
2005 Erasmus grant
Universidad de Salamanca, Spain